Dermal fibroblast altering their actin gene expression (which is silenced in dermal fibroblasts). When dermal fibroblasts express actin, the cells can slowly contract. This contraction plays a critical role in wound healing and fibrosis. By pulling tissues closed differentiated myofibroblasts, seal the skin after an injury (thereby, preventing infection but inducing scar formation. Myofibroblasts can also be derived from non-fibroblast sources. Based on evidence of α-SMA expression from lung injuries, myofibroblasts can "arise de novo" directly from mesenchymal stem cells. Unlike other fibroblast cell types, dermal fibroblasts are far less likely to change into other cell types. For example, when a dermal
Relate Relate Relate is a charity providing relationship support throughout the United Kingdom. Services include counselling for couples, families, young people and individuals, sex therapy, mediation and training courses. It was founded in 1938 as the National Marriage Guidance Council, after a clergyman, Herbert Gray (1868-1956), noted that the divorce rate was increasing. A co-founder of the Council was the Methodist David Mace (1907-1990). Another co-founder was eugenicist Dr Edward Fyfe Griffith. Relate adopted its current name on Valentine's Day 1988. In the 1990s, Relate's public profile increased after Princess Diana became its patron in 1989. Today, Relate sees over 150,000