Dermal fibroblast Dermal fibroblast Dermal fibroblasts are cells within the dermis layer of skin which are responsible for generating connective tissue and allowing the skin to recover from injury. Using organelles (particularly the rough endoplasmic reticulum), dermal fibroblasts generate and maintain the connective tissue which unites separate cell layers. Furthermore, these dermal fibroblasts produce the protein molecules including laminin and fibronectin which comprise the extracellular matrix. By creating the extracellular matrix between the dermis and epidermis, fibroblasts allow the epithelial cells of the epidermis to affix the matrix, thereby allowing the epidermal cells to effectively join together to form the top layer
What Difference Does It Make? What Difference Does It Make? "What Difference Does It Make?" is a song by the English rock band the Smiths, written by singer Morrissey and guitarist Johnny Marr. It was the band's third single and is featured on their debut album, "The Smiths". A different version, recorded for the John Peel Show on BBC Radio 1, is included in the compilation album "Hatful of Hollow". The song was one of the band's first significant chart hits, peaking at No. 12 in the UK Singles Chart. However, Morrissey has said "What Difference Does It Make?" is among his least favourite songs