Dermal fibroblast fibroblast and a corneal fibroblasts are placed in the same concentrations of fibroblast growth factor, dermal fibroblast will not differentiate or change. As noted by Dr. J. Lewis and Dr. A. Johnson authors of "Microbiology of the Cell", "fibroblasts from the skin are different" and behave differently from other fibroblast cells to identical chemical stimuli. Furthermore, dermal fibroblasts are less likely to replicate in either "in vivo" and "in vitro" environments than are other fibroblast types. Dermal fibroblasts require far higher concentrations of fibroblast growth factor (FGF) in order to undergo cell replication. Dermal fibroblasts are responsible for creating the
Post-kala-azar dermal leishmaniasis Post-kala-azar dermal leishmaniasis Post-kala-azar dermal leishmaniasis (PKDL) is a complication of visceral leishmaniasis (VL); it is characterised by a macular, maculopapular, and nodular rash in a patient who has recovered from VL and who is otherwise well. The rash usually starts around the mouth from where it spreads to other parts of the body depending on severity. Post-kala-azar dermal leishmaniasis (also known as "Post-kala-azar dermatosis") found mainly on the face, arms, and upper part of the trunk. It occurs years(in the Indian variation)or a few months(in the African strain) after the successful treatment of visceral leishmaniasis It is mainly seen