Dermal fibroblast of the skin. Dermal fibroblasts are derived from mesenchymal stem cells within the body. Like corneal fibroblasts, dermal fibroblast proliferation can be stimulated by the presence of fibroblast growth factor (FGF). Fibroblasts do not appear to be fully differentiated or specialized. After examining the CD markers of the fibroblast cells, researchers at BioMed Central discovered that these cell lack "distinctive markers" confirming that these cells can be further differentiated. One example of further differentiation of dermal fibroblasts is that upon injury, dermal fibroblasts can give rise to myofibroblasts, fibroblast cells with smooth muscle characteristics. Dermal cells differentiate into myofibroblasts by
What Kate Does reviews"; however, this was down significantly from the previous episode's 89 and Bonnie Covel of About.com noted that " 'What Kate Does' brought us a bit of negativity. In general, fans just didn't like the episode". "What Kate Does" was largely considered to be a step down from the season premiere in pacing, revelations and writing; Mike Hale of "The New York Times" described the episode as "contemplative", "anticlimactic" and "subdued" and the flash sideways as "kind of boring and seemingly pointless." Chris Carabott of IGN, who gave the episode a score of 7.3 summed up that " 'What Kate