Dermal fibroblast wound site perish. Without fibroblasts, the wound site cannot regenerate extracellular matrix and epidermis skin cells cannot proliferate over the wound site. Therefore, without dermal fibroblasts the skin cannot properly recover from injury. Yet, by differentiating mesenchymal stem cells from other regions of the body and injecting them into the wound site, scientists can restore dermal fibroblasts to burned regions of the body. By restoring fibroblasts to the burned regions, the body can restore the ECM within the wound site and recover from the injury. As noted "The injured dermis is also repaired by the recruitment and proliferation of fibroblasts
The purpose of a system is what it does be balanced by a more straightforwardly descriptive view. The term is used in many fields including biology and management. The purpose of a system is what it does The purpose of a system is what it does (POSIWID) is a systems thinking heuristic coined by Stafford Beer. Stafford Beer coined the term POSIWID and used it many times in public addresses. In his address to the University of Valladolid, Spain, in October 2001, he said "According to the cybernetician, the purpose of a system is what it does. This is a basic dictum. It stands for bald fact, which makes