Evolutionary history of plants and radially symmetrical, is an integumented megasporangium surrounded by a cupule. The megasporangium bears an unopened distal extension protruding above the multilobed integument. It is suspected that the extension was involved in anemophilous pollination. "Runcaria" sheds new light on the sequence of character acquisition leading to the seed. "Runcaria" has all of the qualities of seed plants except for a solid seed coat and a system to guide the pollen to the ovule. The first spermatophytes (literally: "seed plants") – that is, the first plants to bear true seeds – are called pteridosperms: literally, "seed ferns", so called because their
Parallel study appropriate if any concerns about carryover effects were present. This type of study might also be more beneficial if the disease or disorder being studied has a likely chance of progression during the time in which the study takes place. One significant issue with parallel studies, though, is the concept of intra subject variability, which is defined as variability in response occurring within the same patient. The two treatment groups in a parallel study can either consist of two completely separate treatments (i.e. different drugs), or simply different doses of a common drug. One major aspect of a parallel study