Body piercing is frequently done in the form of a ladder. Modern body piercing practices also include dermal anchoring or dermal piercing, which combines piercing and implantation to create a single point of opening in the body (whereas pocketing creates two) to permit one end of the jewellery to show above the surface of the skin. While this technique can be performed almost anywhere on the body, as of 2007 it was popularly done between the eyes, on the chest, or on the finger, to simulate a ring. The practice of body piercing is subject to trends and fashions. Belly button and
Dermal fibroblast by researchers at the Harvard Stem Cell Institute, dermal cell "human keratinocyte [stem cells] could be propagated in vitro when culture on fibroblast feeder cells." In addition to improving the culture and proliferation of stem cells, dermal fibroblasts can also become stem cells. Although dermal cells demonstrate less plasticity than other fibroblast cell types, researchers can still turn these cells into induced pluripotent cells (IPCs). As noted by researchers within the Harvard Stem Cell Institute, researchers obtained fibroblasts from a mouse with sickle cell anemia and, using a virus, "reprogrammed these cells into pluripotent [stem cells], corrected the genetic deficiency