Dermal fibroblast altering their actin gene expression (which is silenced in dermal fibroblasts). When dermal fibroblasts express actin, the cells can slowly contract. This contraction plays a critical role in wound healing and fibrosis. By pulling tissues closed differentiated myofibroblasts, seal the skin after an injury (thereby, preventing infection but inducing scar formation. Myofibroblasts can also be derived from non-fibroblast sources. Based on evidence of α-SMA expression from lung injuries, myofibroblasts can "arise de novo" directly from mesenchymal stem cells. Unlike other fibroblast cell types, dermal fibroblasts are far less likely to change into other cell types. For example, when a dermal
What Kate Does reviews"; however, this was down significantly from the previous episode's 89 and Bonnie Covel of About.com noted that " 'What Kate Does' brought us a bit of negativity. In general, fans just didn't like the episode". "What Kate Does" was largely considered to be a step down from the season premiere in pacing, revelations and writing; Mike Hale of "The New York Times" described the episode as "contemplative", "anticlimactic" and "subdued" and the flash sideways as "kind of boring and seemingly pointless." Chris Carabott of IGN, who gave the episode a score of 7.3 summed up that " 'What Kate