Adriatic Sea southeast, the Adriatic Sea connects to the Ionian Sea at the wide Strait of Otranto. The International Hydrographic Organization (IHO) defines the boundary between the Adriatic and the Ionian seas as a line running from the Butrinto River's mouth (latitude 39°44'N) in Albania to the Karagol Cape in Corfu, through this island to the Kephali Cape (these two capes are in latitude 39°45'N), and on to the Santa Maria di Leuca Cape (latitude 39°48'N). It extends from the northwest to the southeast and is wide. It covers and has a volume of . The Adriatic extends northwest from 40° to
Ionian Academy and educational activities in establishing the high level of the Medical School influenced the Greek medical science as a whole. In particular, George Therianos (Prof of General and Comparative Anatomy and Experimental Physics) from the island of Zante (Zakynthos) met the Earl of Guilford in 1825 in England and was given the position of professor of the Academy's Medical School. Giovanni Carandino (Ioannis Karantinos), who had already learnt mathematics with Charles Dupin at the original Ionian Academy established by the French during their occupation of the Septinsular Republic (1807–1824), was sent by Lord Guilford to study at the École Polytechnique