Seed when castor beans have been ingested by animals. In addition, seeds containing amygdalin—apple, apricot, bitter almond, peach, plum, cherry, quince, and others—when consumed in sufficient amounts, may cause cyanide poisoning. Other seeds that contain poisons include annona, cotton, custard apple, datura, uncooked durian, golden chain, horse-chestnut, larkspur, locoweed, lychee, nectarine, rambutan, rosary pea, sour sop, sugar apple, wisteria, and yew. The seeds of the strychnine tree are also poisonous, containing the poison strychnine. The seeds of many legumes, including the common bean ("Phaseolus vulgaris"), contain proteins called lectins which can cause gastric distress if the beans are eaten without cooking.
Substance use disorder addiction, substance dependence, or both. Medically, physiologic dependence requires the development of tolerance leading to withdrawal symptoms. Both abuse and dependence are distinct from addiction which involves a compulsion to continue using the substance despite the negative consequences, and may or may not involve chemical dependency. Dependence often implies abuse, but abuse frequently occurs without dependence, particularly when an individual first begins to abuse a substance. Dependence involves physiological processes while substance abuse reflects a complex interaction between the individual, the abused substance and society. Substance abuse is sometimes used as a synonym for drug abuse, drug addiction, and chemical