Dermal fibroblast ECM which organizes the stratified squamous epithelial cells of the epidermis into a unified tissue. Furthermore, dermal fibroblasts create long fibrous bands of connective tissue which anchor the skin to the fascia of the body. Therefore, without dermal fibroblasts, the largest and heaviest organ would not tightly adhere to body's frame. Since dermal fibroblasts play a critical role in wound healing, researchers are attempting to generate mature dermal fibroblasts to repair second and third degree burns. When the body sustains a third degree burn, the skin's dermal layer is completely destroyed by heat (and the all fibroblast cells within the
What Kate Does reviews"; however, this was down significantly from the previous episode's 89 and Bonnie Covel of About.com noted that " 'What Kate Does' brought us a bit of negativity. In general, fans just didn't like the episode". "What Kate Does" was largely considered to be a step down from the season premiere in pacing, revelations and writing; Mike Hale of "The New York Times" described the episode as "contemplative", "anticlimactic" and "subdued" and the flash sideways as "kind of boring and seemingly pointless." Chris Carabott of IGN, who gave the episode a score of 7.3 summed up that " 'What Kate