Dermal fibroblast wound site perish. Without fibroblasts, the wound site cannot regenerate extracellular matrix and epidermis skin cells cannot proliferate over the wound site. Therefore, without dermal fibroblasts the skin cannot properly recover from injury. Yet, by differentiating mesenchymal stem cells from other regions of the body and injecting them into the wound site, scientists can restore dermal fibroblasts to burned regions of the body. By restoring fibroblasts to the burned regions, the body can restore the ECM within the wound site and recover from the injury. As noted "The injured dermis is also repaired by the recruitment and proliferation of fibroblasts
Cephalopod dermal structures "Lepidoteuthis grimaldii" are actually dermal cushions with a vacuolate internal structure that are continuous with a similarly vacuolate underlying layer of mantle tissue. Ammonium ions (NH) are present in the mantle of this species at a measured concentration of 172 mM. Structurally very similar (though non-overlapping) dermal cushions are found in "Pholidoteuthis adami". It has been proposed that these two species achieve buoyancy by means of the fluid stored in their vacuolate dermal cushions and upper mantle layer. Given their spongy form, these cushions may also play a secondary protective role. The complex dermal structures of "Pholidoteuthis massyae" may play