Zodiac (comics) to hit all of the Zodiac with the antidote before they die while Scorpio uses this to escape. The Zodiac Key is held in the apartment of a man named Mr. Jacobs alongside his Scorpio gear. A solo character called "Zodiac" stars in a self-titled limited series as part of the "Dark Reign" storyline. The character is obsessed with dominating the criminal underworld. He ends up gaining allies in Clown II, Death Reaper, Manslaughter Marsdale, and Trapster. After they commit mass murder on 100 H.A.M.M.E.R. Agents, Zodiac eventually retrieves the Zodiac Key from S.H.I.E.L.D. Zodiac later makes plans for a
Madame Zodiac Zodiac is subdued by Superman, and Doctor Zodiac tells him about the mysterious prisoner. Superman shatters the walls of the magically sealed cell, revealing the real Madame Zodiac chained to a wall. The Madame Zodiac that Doctor Zodiac had fallen in love with was a magical clone. Madame Zodiac reveals that she was attacked and possessed by the shadow demon while astrally exploring other dimensions; the creature used the Gemini aspect of the Zodiac Idol to create her evil duplicate. Madame Zodiac, Doctor Zodiac, and Superman confront the duplicate and its master. Madame Zodiac's body is utterly destroyed by her