Seed when castor beans have been ingested by animals. In addition, seeds containing amygdalin—apple, apricot, bitter almond, peach, plum, cherry, quince, and others—when consumed in sufficient amounts, may cause cyanide poisoning. Other seeds that contain poisons include annona, cotton, custard apple, datura, uncooked durian, golden chain, horse-chestnut, larkspur, locoweed, lychee, nectarine, rambutan, rosary pea, sour sop, sugar apple, wisteria, and yew. The seeds of the strychnine tree are also poisonous, containing the poison strychnine. The seeds of many legumes, including the common bean ("Phaseolus vulgaris"), contain proteins called lectins which can cause gastric distress if the beans are eaten without cooking.
Rambo apple in his chapter on the apple in Botany of Desire, John Chapman (1774–1845), for religious reasons related to the doctrines of Emanuel Swedenborg, believed grafting was an unnatural practice. Chapman was given the nickname "Appleseed" pejoratively for his highly unusual practice of planting trees from seed. Apples grown from seed are most often small and poorly flavored. Back when the frontier only extended as far west as the state of Indiana, that worked fine for Johnny Appleseed, since the apples from his trees were used principally for making hard cider. Also the pioneers didn't have any other choice in suppliers.