Dermal fibroblast altering their actin gene expression (which is silenced in dermal fibroblasts). When dermal fibroblasts express actin, the cells can slowly contract. This contraction plays a critical role in wound healing and fibrosis. By pulling tissues closed differentiated myofibroblasts, seal the skin after an injury (thereby, preventing infection but inducing scar formation. Myofibroblasts can also be derived from non-fibroblast sources. Based on evidence of α-SMA expression from lung injuries, myofibroblasts can "arise de novo" directly from mesenchymal stem cells. Unlike other fibroblast cell types, dermal fibroblasts are far less likely to change into other cell types. For example, when a dermal
What Kate Does week." VanDerWerff of the "LA Times", Ryan of the "Chicago Tribune", Sepinwall of "The Star-Ledger", Jensen of "Entertainment Weekly" and Mark Medley of the "National Post" also found the episode to contain humorous lines. This episode was watched by 11 million American viewers and 1.57 million Canadian viewers. What Kate Does "What Kate Does" is the 106th television episode of the American Broadcasting Company's "Lost" and third episode of the sixth season. It was written by executive producers Edward Kitsis and Adam Horowitz and directed in September 2009 by Paul Edwards. "What Kate Does" was first aired February 9, 2010,