Focal dermal hypoplasia Focal dermal hypoplasia Focal dermal hypoplasia (also known as "Goltz syndrome") is a form of ectodermal dysplasia. It is a multisystem disorder characterized primarily by skin manifestations to the atrophic and hypoplastic areas of skin which are present at birth. These defects manifest as yellow-pink bumps on the skin and pigmentation changes. The disorder is also associated with shortness of stature and some evidence suggests that it can cause epilepsy. Focal dermal hypoplasia has been associated with PORCN gene mutations on the X chromosome. 90% of the individuals who are affected with the syndrome are female: the commonly accepted, though
What Difference Does It Make? What Difference Does It Make? "What Difference Does It Make?" is a song by the English rock band the Smiths, written by singer Morrissey and guitarist Johnny Marr. It was the band's third single and is featured on their debut album, "The Smiths". A different version, recorded for the John Peel Show on BBC Radio 1, is included in the compilation album "Hatful of Hollow". The song was one of the band's first significant chart hits, peaking at No. 12 in the UK Singles Chart. However, Morrissey has said "What Difference Does It Make?" is among his least favourite songs