Dermal fibroblast wound site perish. Without fibroblasts, the wound site cannot regenerate extracellular matrix and epidermis skin cells cannot proliferate over the wound site. Therefore, without dermal fibroblasts the skin cannot properly recover from injury. Yet, by differentiating mesenchymal stem cells from other regions of the body and injecting them into the wound site, scientists can restore dermal fibroblasts to burned regions of the body. By restoring fibroblasts to the burned regions, the body can restore the ECM within the wound site and recover from the injury. As noted "The injured dermis is also repaired by the recruitment and proliferation of fibroblasts
What Difference Does It Make? What Difference Does It Make? "What Difference Does It Make?" is a song by the English rock band the Smiths, written by singer Morrissey and guitarist Johnny Marr. It was the band's third single and is featured on their debut album, "The Smiths". A different version, recorded for the John Peel Show on BBC Radio 1, is included in the compilation album "Hatful of Hollow". The song was one of the band's first significant chart hits, peaking at No. 12 in the UK Singles Chart. However, Morrissey has said "What Difference Does It Make?" is among his least favourite songs