Dermal fibroblast wound site perish. Without fibroblasts, the wound site cannot regenerate extracellular matrix and epidermis skin cells cannot proliferate over the wound site. Therefore, without dermal fibroblasts the skin cannot properly recover from injury. Yet, by differentiating mesenchymal stem cells from other regions of the body and injecting them into the wound site, scientists can restore dermal fibroblasts to burned regions of the body. By restoring fibroblasts to the burned regions, the body can restore the ECM within the wound site and recover from the injury. As noted "The injured dermis is also repaired by the recruitment and proliferation of fibroblasts
Congenital dermal sinus pervasive use and availability of advanced methods of neuroimaging, it is possible that the rate of incidence of congenital dermal sinus has been supplemented by the incidence of coccygeal pits. Coccygeal pits are distinct from congenital dermal sinus as they are found within the gluteal cleft, rather than above the gluteal cleft. The caudally orientated coccygeal pits are not associated with intradural pathology and do not need to be excised, unlike the cephalically oriented tracts of the congenital dermal sinus which confer great intradural pathology and require surgical intervention. While coccygeal pits occur in 4% of neonate population, congenital dermal