Dermal fibroblast by homologous recombination, and redirected these pluripotent cells toward the hematopoietic lineages, and transplanted these engineered cells to a lethally irradiated mice." The animals which received the fibroblast stem cell treatment exhibited increased activity levels, indicating recovery from the disorder. Dermal fibroblast Dermal fibroblasts are cells within the dermis layer of skin which are responsible for generating connective tissue and allowing the skin to recover from injury. Using organelles (particularly the rough endoplasmic reticulum), dermal fibroblasts generate and maintain the connective tissue which unites separate cell layers. Furthermore, these dermal fibroblasts produce the protein molecules including laminin and fibronectin which
Dermal equivalent be incorporated to model the inflammatory phase of wound healing. Dermal equivalent The dermal equivalent is an in vitro model of the dermal layer of skin. It is constructed by seeding dermal fibroblasts into a collagen gel. This gel may then be allowed to contract as a model of wound contraction. This collagen gel contraction assay may be used to screen for treatments which promote or inhibit contraction and thus affect the development of a scar. Other cell types may be incorporated into the dermal equivalent to increase the complexity of the model. For example, keratinocytes may be seeded on