Dermal fibroblast wound site perish. Without fibroblasts, the wound site cannot regenerate extracellular matrix and epidermis skin cells cannot proliferate over the wound site. Therefore, without dermal fibroblasts the skin cannot properly recover from injury. Yet, by differentiating mesenchymal stem cells from other regions of the body and injecting them into the wound site, scientists can restore dermal fibroblasts to burned regions of the body. By restoring fibroblasts to the burned regions, the body can restore the ECM within the wound site and recover from the injury. As noted "The injured dermis is also repaired by the recruitment and proliferation of fibroblasts
What Kate Does What Kate Does "What Kate Does" is the 106th television episode of the American Broadcasting Company's "Lost" and third episode of the sixth season. It was written by executive producers Edward Kitsis and Adam Horowitz and directed in September 2009 by Paul Edwards. "What Kate Does" was first aired February 9, 2010, on ABC in the United States and on CTV in Canada. Kate Austen is the character on whom the episode is centered. In December 2007, Kate Austen chases after James "Sawyer" Ford (Josh Holloway), who escapes from the Others' captivity in the island's temple and is grieving over