United States of the Ionian Islands took Lefkada in 1810. The island of Corfu remained occupied by the French until 1814. The Congress of Vienna agreed to place the Ionian Islands under the exclusive "amical protection" of the United Kingdom. Despite British military administration, the Austrian Empire was guaranteed commercial status equal to the UK. The arrangement was formalised with the ratification of the "Maitland constitution" on 26 August 1817, which created a federation of the seven islands, with Lieutenant-General Sir Thomas Maitland its first "Lord High Commissioner of the Ionian Islands". The Party of Radicals (Greek: Κόμμα των Ριζοσπαστών) founded in 1848 was against the
Ionian Academy and educational activities in establishing the high level of the Medical School influenced the Greek medical science as a whole. In particular, George Therianos (Prof of General and Comparative Anatomy and Experimental Physics) from the island of Zante (Zakynthos) met the Earl of Guilford in 1825 in England and was given the position of professor of the Academy's Medical School. Giovanni Carandino (Ioannis Karantinos), who had already learnt mathematics with Charles Dupin at the original Ionian Academy established by the French during their occupation of the Septinsular Republic (1807–1824), was sent by Lord Guilford to study at the École Polytechnique