Zodiac (comics) to hit all of the Zodiac with the antidote before they die while Scorpio uses this to escape. The Zodiac Key is held in the apartment of a man named Mr. Jacobs alongside his Scorpio gear. A solo character called "Zodiac" stars in a self-titled limited series as part of the "Dark Reign" storyline. The character is obsessed with dominating the criminal underworld. He ends up gaining allies in Clown II, Death Reaper, Manslaughter Marsdale, and Trapster. After they commit mass murder on 100 H.A.M.M.E.R. Agents, Zodiac eventually retrieves the Zodiac Key from S.H.I.E.L.D. Zodiac later makes plans for a
Madame Zodiac Doctor Zodiac from prison and left a mystical illusion in his freed. She freed him because she had his Zodiac Idol, but wanted access to the Zodiac Coins that provide its power. She uses Doctor Zodiac's mystical connection to the twelve Atlantean to steal them from the coin collectors who currently owned them. Now possessing all twelve coins she is able to activate the Zodiac Idol. It is also revealed that Theo (Doctor Zodiac) and Marissa (Madame Zodiac) are now romantically involved. Theo discovers that she has used the Zodiac Idol to contact an ancient other-dimensional evil she refers to