Pathophysiology of heart failure caused by dysfunction or destruction of cardiac myocytes or their molecular components. In congenital diseases such as Duchenne muscular dystrophy, the molecular structure of individual myocytes is affected. Myocytes and their components can be damaged by inflammation (such as in myocarditis) or by infiltration (such as in amyloidosis). Toxins and pharmacological agents (such as ethanol, cocaine, doxorubicin, and amphetamines) cause intracellular damage and oxidative stress. The most common mechanism of damage is ischemia causing infarction and scar formation. After myocardial infarction, dead myocytes are replaced by scar tissue, deleteriously affecting the function of the myocardium. On echocardiogram, this is manifest
History of beliefs about the human body much on discourse about bodies, rather than on material bodies themselves. Drawing on Mikhail Bakhtin's 1965 "Rabelais and His World", they promoted a more materially orientated direction in the history of the body. The Ebers Papyrus is an Egyptian medical text and is the oldest known record of the human body, dating back to 3000 BC. The Ebers Papyrus describes the body by physical examination and what can be felt. Clinical investigations such as the Pulse, percussion of the body, the recognition of diseased or disordered states. “If thou examinst a swelling of the covering of his belly’s horns above