Otic vesicle constricts to form the canalis reuniens. The central part of the otic vesicle represents the membranous vestibule, and is subdivided by a constriction into a smaller ventral part, the saccule, and a larger dorsal and posterior part, the utricle. The dorsal component of the inner ear also consists of what will become the semicircular canals. The utricle and saccule communicate with each other by means of a Y-shaped canal. The FGF, Bmp, Wnt and Pax genes are likely to be involved in otic induction. FGF and BMP signals help control patterning in the early otic vesicle. Fgf3 and Fgf10 are
The Anatomy of Melancholy melancholia (which includes, although it is not limited to, what is now termed clinical depression). Although presented as a medical text, "The Anatomy of Melancholy" is as much a "sui generis" work of literature as it is a scientific or philosophical text, and Burton addresses far more than his stated subject. In fact, the "Anatomy" uses melancholy as the lens through which all human emotion and thought may be scrutinized, and virtually the entire contents of a 17th-century library are marshalled into service of this goal. It is encyclopedic in its range and reference. In his satirical preface to the