Otic vesicle constricts to form the canalis reuniens. The central part of the otic vesicle represents the membranous vestibule, and is subdivided by a constriction into a smaller ventral part, the saccule, and a larger dorsal and posterior part, the utricle. The dorsal component of the inner ear also consists of what will become the semicircular canals. The utricle and saccule communicate with each other by means of a Y-shaped canal. The FGF, Bmp, Wnt and Pax genes are likely to be involved in otic induction. FGF and BMP signals help control patterning in the early otic vesicle. Fgf3 and Fgf10 are
Limb (anatomy) Limb (anatomy) A limb (from the Old English "lim"), or extremity, is a jointed, or prehensile (as octopus arms or new world monkey tails), appendage of the human or other animal body. In the human body, the upper and lower limbs are commonly called the arms and the legs, respectively. Arms and legs are connected to torso or trunk. Many animals use limbs for locomotion, such as walking, running, or climbing. Some animals can use their front limbs (or upper limbs in humans) to carry and manipulate objects. Some animals can also use hind limbs for manipulation. Human legs and