Vogt–Koyanagi–Harada disease Vogt–Koyanagi–Harada disease Vogt–Koyanagi–Harada disease (VKH), also known as Vogt–Koyanagi–Harada syndrome, uveomeningitis syndrome and uveomeningoencephalitic syndrome, is a multisystem disease of presumed autoimmune cause, that affects pigmented tissues, which have melanin. The most significant manifestation is bilateral, diffuse uveitis, which affects the eye. VKH may variably also involve the inner ear with effects on hearing, the skin, and the meninges of the central nervous system. The disease is characterised by bilateral diffuse uveitis, with pain, redness and blurring of vision. The eye symptoms may be accompanied by a varying constellation of systemic symptoms, such as auditory (tinnitus, vertigo, and hypoacusis), neurological
Kawasaki disease arteries are involved, ongoing treatment or surgery may occasionally be required. Without treatment, coronary artery problems occur in up to 25% and about 1% die. With treatment, the risk of death is 0.17%. Kawasaki disease is rare. It affects between 8 and 67 per 100,000 people under the age of five except in Japan where it affects 124 per 100,000. It is much less common after the age of five. Boys are more commonly affected than girls. The disorder was first described in 1967 by Tomisaku Kawasaki in Japan. Kawasaki disease often begins with a high and persistent fever that