Otic vesicle the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across vertebrates, although there is much variation in timing and stages. Patterning during morphogenesis into the distinctive inner ear structures is determined by homeobox transcription factors including PAX2, DLX5 and DLX6, with the former specifying for ventral otic vesicle derived auditory structures and the latter two specifying for dorsal vestibular structures. The otic vesicle is derived from the cranial placode. The early otic vesicle is characterized as having broad competence
The Anatomy of Melancholy melancholia (which includes, although it is not limited to, what is now termed clinical depression). Although presented as a medical text, "The Anatomy of Melancholy" is as much a "sui generis" work of literature as it is a scientific or philosophical text, and Burton addresses far more than his stated subject. In fact, the "Anatomy" uses melancholy as the lens through which all human emotion and thought may be scrutinized, and virtually the entire contents of a 17th-century library are marshalled into service of this goal. It is encyclopedic in its range and reference. In his satirical preface to the