Otic vesicle constricts to form the canalis reuniens. The central part of the otic vesicle represents the membranous vestibule, and is subdivided by a constriction into a smaller ventral part, the saccule, and a larger dorsal and posterior part, the utricle. The dorsal component of the inner ear also consists of what will become the semicircular canals. The utricle and saccule communicate with each other by means of a Y-shaped canal. The FGF, Bmp, Wnt and Pax genes are likely to be involved in otic induction. FGF and BMP signals help control patterning in the early otic vesicle. Fgf3 and Fgf10 are
History of anatomy been debunked as a myth by modern historians of science. For many decades human dissection was thought unnecessary when all the knowledge about a human body could be read about from early authors such as Galen. In the 12th century, as universities were being established in Italy, Emperor Frederick II made it mandatory for students of medicine to take courses on human anatomy and surgery. Students who had the opportunity to watch Vesalius in dissection at times had the opportunity to interact with the animal corpse. At the risk of letting their eagerness to participate become a distraction to their