Akodon spegazzinii is found in northwestern Argentina, in the provinces of Salta, Catamarca, Tucumán, La Rioja, and Mendoza, at altitudes of . Although its main distribution is in the northern provinces of Salta, Tucumán, and Catamarca, there are also scattered records from the more southern provinces of La Rioja and Mendoza, where it is likely restricted to patches of wet habitat. "Akodon alterus" has been reported from Jujuy, but this record was likely based on misidentified specimens of "A. boliviensis", and records of "Akodon spegazzinii" from Jujuy were based on misidentified "A. sylvanus". "Akodon spegazzinii" is known from a paleontological site in
Catamarca Province (partly through La Rioja) to Chile by the Paso de San Francisco (4722 m), 64 west from Santiago del Estero to join 38 and 157 north from La Guardia 103 km to Frias where it connects with 89 west from Villa San Martin (Santiago del Estero), and north to Tucuman province at San Pedro, connecting with 64 near Las Cañas. There is an airport at Catamarca. Since its foundation in 1991 by the Catamarcan branch of the Radical Civic Union and minor local parties the Civic and Social Front of Catamarca has dominated state politics. It has held the governor's