Otic vesicle the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across vertebrates, although there is much variation in timing and stages. Patterning during morphogenesis into the distinctive inner ear structures is determined by homeobox transcription factors including PAX2, DLX5 and DLX6, with the former specifying for ventral otic vesicle derived auditory structures and the latter two specifying for dorsal vestibular structures. The otic vesicle is derived from the cranial placode. The early otic vesicle is characterized as having broad competence
History of beliefs about the human body manuscript is recorded in the Yellow Emperors Inner Cannon, and it being recorded in this way represents the attention to the individuals perspective in creating therapies like acupuncture to treat body ailments. The Inner Cannon was revised by natural Philosophers of the time and the approved version of the Han Court and became a foundational text for the ideals and perceptions of the human body. It focused on Qi, Yin and Yang balance, and Five phase theory to explain health can disease. Referred to as the life force of the body, or the means by which the body is able