Pathophysiology of heart failure caused by dysfunction or destruction of cardiac myocytes or their molecular components. In congenital diseases such as Duchenne muscular dystrophy, the molecular structure of individual myocytes is affected. Myocytes and their components can be damaged by inflammation (such as in myocarditis) or by infiltration (such as in amyloidosis). Toxins and pharmacological agents (such as ethanol, cocaine, doxorubicin, and amphetamines) cause intracellular damage and oxidative stress. The most common mechanism of damage is ischemia causing infarction and scar formation. After myocardial infarction, dead myocytes are replaced by scar tissue, deleteriously affecting the function of the myocardium. On echocardiogram, this is manifest
Explorers of the Human Body new educational program, introducing the audience to the human body. Shin Dong-yup was chosen to be the lead MC, with the Super Junior members being regulars and co-MCs of the program. Ratings for the show became the highest of all three shows that aired in SBS's new "Good Sunday" lineup as the show is educational and entertaining to watch. It was also the first and currently the only variety show that included every member of Super Junior as regulars. Each episode has a main topic to explore regarding the human body. In the first episode, which involved the tongue and