Pathophysiology of heart failure caused by dysfunction or destruction of cardiac myocytes or their molecular components. In congenital diseases such as Duchenne muscular dystrophy, the molecular structure of individual myocytes is affected. Myocytes and their components can be damaged by inflammation (such as in myocarditis) or by infiltration (such as in amyloidosis). Toxins and pharmacological agents (such as ethanol, cocaine, doxorubicin, and amphetamines) cause intracellular damage and oxidative stress. The most common mechanism of damage is ischemia causing infarction and scar formation. After myocardial infarction, dead myocytes are replaced by scar tissue, deleteriously affecting the function of the myocardium. On echocardiogram, this is manifest
History of beliefs about the human body is important to understanding histories of coercion and control, sex and gender, and other important but culturally varied aspects of human experience. Another prominent voice in the field at the same time was Caroline Walker Bynum, whose 1988 "Holy Feast and Holy Fast" became a landmark study. Both Bynum and Porter noted that during the 1980s Western history of the body research drew on post-structuralist thought, such as Michel Foucault's ideas of biopolitics and biopower, which emphasised that state power is not abstract, but exercised through and over human bodies. But both expressed a concern that research was focusing too