Pathophysiology of heart failure caused by dysfunction or destruction of cardiac myocytes or their molecular components. In congenital diseases such as Duchenne muscular dystrophy, the molecular structure of individual myocytes is affected. Myocytes and their components can be damaged by inflammation (such as in myocarditis) or by infiltration (such as in amyloidosis). Toxins and pharmacological agents (such as ethanol, cocaine, doxorubicin, and amphetamines) cause intracellular damage and oxidative stress. The most common mechanism of damage is ischemia causing infarction and scar formation. After myocardial infarction, dead myocytes are replaced by scar tissue, deleteriously affecting the function of the myocardium. On echocardiogram, this is manifest
Muscular system of the horse Muscular system of the horse There are 3 types of muscle, all found within the equine: Skeletal muscle is made up of several muscle bundles, which in turn are made up of muscle fibers. Muscle fibers have bundles of myofibrils, which are all parallel to one another, and are able to contract due to actin and myosin. Muscle is covered by a fibrous tissue called fascia, to which other muscles can attach, and muscles attach to bone via tendons. Tendons attach muscles and bone, and are classified as flexors (flex a joint) or extensors (extend a joint). However, some tendons