Pathophysiology of heart failure caused by dysfunction or destruction of cardiac myocytes or their molecular components. In congenital diseases such as Duchenne muscular dystrophy, the molecular structure of individual myocytes is affected. Myocytes and their components can be damaged by inflammation (such as in myocarditis) or by infiltration (such as in amyloidosis). Toxins and pharmacological agents (such as ethanol, cocaine, doxorubicin, and amphetamines) cause intracellular damage and oxidative stress. The most common mechanism of damage is ischemia causing infarction and scar formation. After myocardial infarction, dead myocytes are replaced by scar tissue, deleteriously affecting the function of the myocardium. On echocardiogram, this is manifest
Body Worlds any connection between the closed Chinese exhibition and his Body Worlds franchise. Similar exhibitions had already been successfully staged in Lyon and Marseille. The UK Parliament created legislation for exhibits of human remains, including plastinated bodies and body parts, in England and Wales under the Human Tissue Act 2004. This requires a licence to be granted by the Human Tissue Authority. The Human Tissue Act superseded the Anatomy Act 1832, which had been found by an independent commission (The Redfern Report) to be inadequate on contemporary collection and use of human tissues, following the Alder Hey organs scandal. In March