Otic vesicle the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across vertebrates, although there is much variation in timing and stages. Patterning during morphogenesis into the distinctive inner ear structures is determined by homeobox transcription factors including PAX2, DLX5 and DLX6, with the former specifying for ventral otic vesicle derived auditory structures and the latter two specifying for dorsal vestibular structures. The otic vesicle is derived from the cranial placode. The early otic vesicle is characterized as having broad competence
Limb (anatomy) feet are specialized for two-legged locomotion – most other mammals walk and run on all four limbs. Human arms are weaker, but very mobile allowing us to reach at a wide range of distances and angles, and end in specialized hands capable of grasping and fine manipulation of objects. Limb (anatomy) A limb (from the Old English "lim"), or extremity, is a jointed, or prehensile (as octopus arms or new world monkey tails), appendage of the human or other animal body. In the human body, the upper and lower limbs are commonly called the arms and the legs, respectively. Arms