Akodon spegazzinii is found in northwestern Argentina, in the provinces of Salta, Catamarca, Tucumán, La Rioja, and Mendoza, at altitudes of . Although its main distribution is in the northern provinces of Salta, Tucumán, and Catamarca, there are also scattered records from the more southern provinces of La Rioja and Mendoza, where it is likely restricted to patches of wet habitat. "Akodon alterus" has been reported from Jujuy, but this record was likely based on misidentified specimens of "A. boliviensis", and records of "Akodon spegazzinii" from Jujuy were based on misidentified "A. sylvanus". "Akodon spegazzinii" is known from a paleontological site in
Tobacco industry in Argentina are concentrated in the north of the country. The provinces of Jujuy and Salta (in the north-west), and Misiones (in the north-eastern Mesopotamia), are the leading ones, with over 45,000 tonnes/year each. The other tobacco-producing provinces are Tucumán, Corrientes, Chaco and Catamarca. Tobacco plays an important role in the economy of the producing areas, which are comparatively poor provinces. The Argentine tobacco industry employs 500,000 people, about half of them directly involved in the planting and harvesting, only about 2% in the manufacturing of the derived products, and the rest in distribution and sales. Therefore, despite the fact that the