Pathophysiology of heart failure caused by dysfunction or destruction of cardiac myocytes or their molecular components. In congenital diseases such as Duchenne muscular dystrophy, the molecular structure of individual myocytes is affected. Myocytes and their components can be damaged by inflammation (such as in myocarditis) or by infiltration (such as in amyloidosis). Toxins and pharmacological agents (such as ethanol, cocaine, doxorubicin, and amphetamines) cause intracellular damage and oxidative stress. The most common mechanism of damage is ischemia causing infarction and scar formation. After myocardial infarction, dead myocytes are replaced by scar tissue, deleteriously affecting the function of the myocardium. On echocardiogram, this is manifest
History of beliefs about the human body body has in the world. All cultural ideals of the body in the early modern period deal with deficiencies and disorders within a body, commonly told through a male ideal. Ideas of the body in the early modern period form the history of how bodies should be and how to correct the body when something has gone wrong. Therefore, early modern conceptions of the body were not biological as there was not a restrictive biological view of the human body as established by modern science. Conceptions of the body are primarily either eastern, based in China and involving practices such