Systole heart beats—is cued by messages from the brain, reflecting the brain's responses to conditions of the body, such as pain, emotional stress, level of activity, and to ambient conditions including external temperature, time of day, etc. Electrical systole opens voltage-gated sodium, potassium and calcium channels in cells of myocardium tissue. Subsequently, a rise in intracellular calcium triggers the interaction of actin and myosin in the presence of ATP which generates mechanical force in the cells in the form of muscular contraction, or mechanical systole. The contractions generate intra-ventricular pressure, which is increased until it exceeds the external, residual pressures in
Traditional Chinese medicines derived from the human body centuries after Li Shizhen considered the bioethical and biomedical dilemmas of using human drugs, 20th-century technological and medical advances have raised new related questions of organ transplants, transplantation medicine, organ trade, tissue banks, human cloning, and the commodification of human body parts (Awaya 1999, Nie 2002, Scheper-Hughes and Wacquant 2002). Traditional Chinese medicines derived from the human body Li Shizhen's (1597) "Bencao gangmu", the classic materia medica of traditional Chinese medicine (TCM), included 35 human drugs, including organs, bodily fluids, and excreta. Crude drugs derived from the human body were commonplace in the early history of medicine. Some of these