Vogt–Koyanagi–Harada disease Vogt–Koyanagi–Harada disease Vogt–Koyanagi–Harada disease (VKH), also known as Vogt–Koyanagi–Harada syndrome, uveomeningitis syndrome and uveomeningoencephalitic syndrome, is a multisystem disease of presumed autoimmune cause, that affects pigmented tissues, which have melanin. The most significant manifestation is bilateral, diffuse uveitis, which affects the eye. VKH may variably also involve the inner ear with effects on hearing, the skin, and the meninges of the central nervous system. The disease is characterised by bilateral diffuse uveitis, with pain, redness and blurring of vision. The eye symptoms may be accompanied by a varying constellation of systemic symptoms, such as auditory (tinnitus, vertigo, and hypoacusis), neurological
Dieterich's disease or therapy. The cause of Dieterich’s disease is still not fully understood. The disease can afflict patients of any age, but typically affects patients in their 30's. Though rare, it can also occur in children. Statistics show that generally more men are affected by Dieterich's than women in an estimated ratio of 3:2. The third (middle finger) metacarpal head has been reported to be the most common site of necrosis. Though osteonecrosis is a fairly common condition, many cases of avascular necrosis of the metacarpal hand go without being diagnosed. This is because presentation of symptoms is variable depending on