Otic vesicle the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across vertebrates, although there is much variation in timing and stages. Patterning during morphogenesis into the distinctive inner ear structures is determined by homeobox transcription factors including PAX2, DLX5 and DLX6, with the former specifying for ventral otic vesicle derived auditory structures and the latter two specifying for dorsal vestibular structures. The otic vesicle is derived from the cranial placode. The early otic vesicle is characterized as having broad competence
Surface anatomy and in motion. In addition, the science of surface anatomy includes the theories and systems of body proportions and related artistic canons. The study of surface anatomy is the basis for depicting the human body in classical art. Some pseudo-sciences such as physiognomy, phrenology and palmistry rely on surface anatomy. Knowledge of the surface anatomy of the thorax (chest) is particularly important because it is one of the areas most frequently subjected to physical examination, like auscultation and percussion.In cardiology, Erb's point refers to the third intercostal space on the left sternal border where S2 heart sound is best auscultated.