Otic vesicle constricts to form the canalis reuniens. The central part of the otic vesicle represents the membranous vestibule, and is subdivided by a constriction into a smaller ventral part, the saccule, and a larger dorsal and posterior part, the utricle. The dorsal component of the inner ear also consists of what will become the semicircular canals. The utricle and saccule communicate with each other by means of a Y-shaped canal. The FGF, Bmp, Wnt and Pax genes are likely to be involved in otic induction. FGF and BMP signals help control patterning in the early otic vesicle. Fgf3 and Fgf10 are
Otic vesicle and can be subdivided into sensory, non-sensory, and neurogenic components. Sensory epithelial cells and neurons are derived from the proneurosensory domain. This domain can be further sub-categorized into the neurogenic sub-domain and prosensory sub-domain. Prosensory sub-domain eventually gives rise to the support cells and hair cells while the neurogenic sub-domain gives rise to the auditory neuron and vestibular neuron. The middle part of the otic vesicle develops into the ductus and saccus endolymphaticus. The anterior end of the otic vesicle gradually elongates as a tube and coils upon itself forming the beginnings of the cochlear duct. The vestibular extremity subsequently