Pathophysiology of heart failure caused by dysfunction or destruction of cardiac myocytes or their molecular components. In congenital diseases such as Duchenne muscular dystrophy, the molecular structure of individual myocytes is affected. Myocytes and their components can be damaged by inflammation (such as in myocarditis) or by infiltration (such as in amyloidosis). Toxins and pharmacological agents (such as ethanol, cocaine, doxorubicin, and amphetamines) cause intracellular damage and oxidative stress. The most common mechanism of damage is ischemia causing infarction and scar formation. After myocardial infarction, dead myocytes are replaced by scar tissue, deleteriously affecting the function of the myocardium. On echocardiogram, this is manifest
Errors of the Human Body screening, Sheean himself said, "The film is about a breakdown in communication, both on the surface in the characters and internally with the cells." Errors of the Human Body Errors of the Human Body is a 2012 psychological thriller directed by Eron Sheean and starring Michael Eklund. Dr. Geoff Burton (Eklund), a brilliant genetics researcher, is invited to a lab in Dresden, only to discover a lethal virus is being created, which he may have unintentionally caused and be its first victim. This mystery is set against Dr. Burton trying to find redemption and peace from a past haunted by