Otic vesicle the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across vertebrates, although there is much variation in timing and stages. Patterning during morphogenesis into the distinctive inner ear structures is determined by homeobox transcription factors including PAX2, DLX5 and DLX6, with the former specifying for ventral otic vesicle derived auditory structures and the latter two specifying for dorsal vestibular structures. The otic vesicle is derived from the cranial placode. The early otic vesicle is characterized as having broad competence
History of anatomy in the 19th century horror of being the subject of dissection. The criminal temptations ultimately led to the 1827–1828 West Port murders in Edinburgh, UK, where likely candidates were killed and sold for cash. The murders led to the passing of the Anatomy Act 1832 which finally provided for an adequate and legitimate supply of corpses. History of anatomy in the 19th century The history of anatomy in the 19th century saw anatomists largely finalise and systematise the descriptive human anatomy of the previous century. The discipline also progressed to establish growing sources of knowledge in histology and developmental biology, not only of humans