Otic vesicle the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across vertebrates, although there is much variation in timing and stages. Patterning during morphogenesis into the distinctive inner ear structures is determined by homeobox transcription factors including PAX2, DLX5 and DLX6, with the former specifying for ventral otic vesicle derived auditory structures and the latter two specifying for dorsal vestibular structures. The otic vesicle is derived from the cranial placode. The early otic vesicle is characterized as having broad competence
The Description of the Human Body soul. A sick or injured body does not do what we want or moves in ways we do not want. He believed the death of the body stopped it from being fit to bring about movement. This did not necessarily happen because the soul left the body. René Descartes believed the body could exist through mechanical means alone. This included digestion, blood circulation, muscle movement and some brain function. He felt we all know what the human body is like because animals have similar bodies and we have all seen them opened up. He saw the body as a machine.