Pathophysiology of heart failure caused by dysfunction or destruction of cardiac myocytes or their molecular components. In congenital diseases such as Duchenne muscular dystrophy, the molecular structure of individual myocytes is affected. Myocytes and their components can be damaged by inflammation (such as in myocarditis) or by infiltration (such as in amyloidosis). Toxins and pharmacological agents (such as ethanol, cocaine, doxorubicin, and amphetamines) cause intracellular damage and oxidative stress. The most common mechanism of damage is ischemia causing infarction and scar formation. After myocardial infarction, dead myocytes are replaced by scar tissue, deleteriously affecting the function of the myocardium. On echocardiogram, this is manifest
Edmund Alexander Parkes Exercise on the Elimination of Nitrogen". He confirmed independently the observations of Adolf Eugen Fick and Johannes Wislicenus, against Justus Liebig's theory that muscular work implies the destruction of muscular tissue by oxidation. Parkes suggested that the elimination of urea is not dependent on the amount of muscular exercise, but on the consumption of nitrogenous food; and that muscular tissue does not consume itself as a fuel doing work. His experiments on the effects of alcohol on the human body (in which he was assisted by Cyprian Wollowicz) were in three papers (in 1870, 1872, and 1874), on the "Effects