Pathophysiology of heart failure caused by dysfunction or destruction of cardiac myocytes or their molecular components. In congenital diseases such as Duchenne muscular dystrophy, the molecular structure of individual myocytes is affected. Myocytes and their components can be damaged by inflammation (such as in myocarditis) or by infiltration (such as in amyloidosis). Toxins and pharmacological agents (such as ethanol, cocaine, doxorubicin, and amphetamines) cause intracellular damage and oxidative stress. The most common mechanism of damage is ischemia causing infarction and scar formation. After myocardial infarction, dead myocytes are replaced by scar tissue, deleteriously affecting the function of the myocardium. On echocardiogram, this is manifest
Errors of the Human Body Ruzin of Screen Invasion wrote, ""Errors of the Human Body" is elevated by a sublime turn by star Michael Eklund... His agony, particularly in the third act, is brilliantly painful. Despite the screenplay skimming over his character’s supposed scientific prowess, to the film’s moderate detriment, Eklund’s powerful performance is nonetheless tragic and captivating." Michael Treveloni of Film School Rejects noted, "The film is a not just a science-fiction horror story: it is a commentary on the importance of dialog, showcasing the need for communication in its many forms. With Geoff, "Errors" presents the perfect, damaged subject.". At the Fantastic Fest