Pathophysiology of heart failure caused by dysfunction or destruction of cardiac myocytes or their molecular components. In congenital diseases such as Duchenne muscular dystrophy, the molecular structure of individual myocytes is affected. Myocytes and their components can be damaged by inflammation (such as in myocarditis) or by infiltration (such as in amyloidosis). Toxins and pharmacological agents (such as ethanol, cocaine, doxorubicin, and amphetamines) cause intracellular damage and oxidative stress. The most common mechanism of damage is ischemia causing infarction and scar formation. After myocardial infarction, dead myocytes are replaced by scar tissue, deleteriously affecting the function of the myocardium. On echocardiogram, this is manifest
Catholic theology of the body dominating all subordinate material instincts, becomes similar to God. This similarity must be goal of all human undertaking. Gregory of Nazianzus (330-390) contemplated on the origin of the human body. Man was created by God with body and soul, a visible and invisible part, like the angels. He was created to praise God like they did. The body was given to man, so he may suffer and eventually die, and thus not consider himself to be God. The material essence of the body separates us from God, like a cloud, or, as Gregory stated, like the cloud between the Egyptians