Otic vesicle the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across vertebrates, although there is much variation in timing and stages. Patterning during morphogenesis into the distinctive inner ear structures is determined by homeobox transcription factors including PAX2, DLX5 and DLX6, with the former specifying for ventral otic vesicle derived auditory structures and the latter two specifying for dorsal vestibular structures. The otic vesicle is derived from the cranial placode. The early otic vesicle is characterized as having broad competence
Grotesque body (where the body can be entered). Eating, drinking, burping from excess, etc. is all done through the mouth. Rabelais uses the Carnival to refer to politics and critique the world based on human anatomy. In the Italian celebration of Carnival, masks play a major role as many people wear them during the celebration. Many of these masks can be seen as an exaggeration of the grotesque as they feature enlarged facial elements such as an enlarged nose (which is a part of the grotesque body). The Italian celebration of carnival is similar to that of Mardi Gras where food and