Otic vesicle the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across vertebrates, although there is much variation in timing and stages. Patterning during morphogenesis into the distinctive inner ear structures is determined by homeobox transcription factors including PAX2, DLX5 and DLX6, with the former specifying for ventral otic vesicle derived auditory structures and the latter two specifying for dorsal vestibular structures. The otic vesicle is derived from the cranial placode. The early otic vesicle is characterized as having broad competence
History of anatomy in the 19th century the third volume and the work was completed by P.J. Roux and M.F.R. Buisson. Henry Gray, an English anatomist and surgeon at St. George's Hospital, published "Gray's Anatomy". With the artist abilities and help of Henry Vandyke Carter, Gray produced an inexpensive and accessible anatomy textbook for medical students. Dissecting unclaimed bodies from workhouse and hospital mortuaries through the Anatomy Act of 1832, the two worked for 18 months on what would form the basis of the book. Their work was first published in 1858. The growth of medical science and medical practice created an increased demand for human cadavers