Akodon spegazzinii is found in northwestern Argentina, in the provinces of Salta, Catamarca, Tucumán, La Rioja, and Mendoza, at altitudes of . Although its main distribution is in the northern provinces of Salta, Tucumán, and Catamarca, there are also scattered records from the more southern provinces of La Rioja and Mendoza, where it is likely restricted to patches of wet habitat. "Akodon alterus" has been reported from Jujuy, but this record was likely based on misidentified specimens of "A. boliviensis", and records of "Akodon spegazzinii" from Jujuy were based on misidentified "A. sylvanus". "Akodon spegazzinii" is known from a paleontological site in
Catamarca Province the Snow-Covered Summits of Aconquija, and the San Francisco Pass. The road over the San Francisco Pass, an endeavor developed during the Castillo Administrations (1991–2003) at a high cost in public funds has failed to bring trade and tourism to the underdeveloped Tinogasta county. Cultural attractions include the city of Catamarca, the archaeological park "Las Huellas del Inca", prehistoric petroglyphs, local music, handcrafts and wines. Major highways include Ruta 33 from Catamarca 98 km south to San Martin, 38 from Catamarca north via San Pedro 228 km to Tucuman, 60 north-west from Córdoba Province 577 km from La Guardia north-west