Otic vesicle Otic vesicle Otic vesicle, or auditory vesicle, consists of either of the two sac-like invaginations formed and subsequently closed off during embryonic development. It is part of the neural ectoderm, which will develop into the membranous labyrinth of the inner ear. This labyrinth is a continuous epithelium, giving rise to the vestibular system and auditory components of the inner ear. During the earlier stages of embryogenesis, the otic placode invaginates to produce the otic cup. Thereafter, the otic cup closes off, creating the otic vesicle. Once formed, the otic vesicle will reside next to the neural tube medially, and on
The Anatomy of Melancholy melancholia (which includes, although it is not limited to, what is now termed clinical depression). Although presented as a medical text, "The Anatomy of Melancholy" is as much a "sui generis" work of literature as it is a scientific or philosophical text, and Burton addresses far more than his stated subject. In fact, the "Anatomy" uses melancholy as the lens through which all human emotion and thought may be scrutinized, and virtually the entire contents of a 17th-century library are marshalled into service of this goal. It is encyclopedic in its range and reference. In his satirical preface to the