Otic vesicle the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across vertebrates, although there is much variation in timing and stages. Patterning during morphogenesis into the distinctive inner ear structures is determined by homeobox transcription factors including PAX2, DLX5 and DLX6, with the former specifying for ventral otic vesicle derived auditory structures and the latter two specifying for dorsal vestibular structures. The otic vesicle is derived from the cranial placode. The early otic vesicle is characterized as having broad competence
Human body writing the influential book "De humani corporis fabrica". Anatomy advanced further with the invention of the microscope and the study of the cellular structure of tissues and organs. Modern anatomy uses techniques such as magnetic resonance imaging, computed tomography, fluoroscopy and ultrasound imaging to study the body in unprecedented detail. The study of human physiology began with Hippocrates in Ancient Greece, around 420 BC, and with Aristotle (384–322 BC) who applied critical thinking and emphasis on the relationship between structure and function. Galen (c. 126–199) was the first to use experiments to probe the body's functions. The term physiology was