Otic vesicle the lateral side will be paraxial mesoderm. Neural crest cells will migrate rostral and caudal to the placode. The general sequence in formation of the otic vesicle is relatively conserved across vertebrates, although there is much variation in timing and stages. Patterning during morphogenesis into the distinctive inner ear structures is determined by homeobox transcription factors including PAX2, DLX5 and DLX6, with the former specifying for ventral otic vesicle derived auditory structures and the latter two specifying for dorsal vestibular structures. The otic vesicle is derived from the cranial placode. The early otic vesicle is characterized as having broad competence
History of beliefs about the human body as imbalances of the 4 fluids of the body. Aristotle was unable to dissect humans but did so to many animals and was a early founder of comparative anatomy. Aristotle did contend quasi spiritual manifestations of the body principally through sexual distinctions. He wrote that the sex of humans: “is determined by the male principle already contained in the semen. If this is not strong enough, then the opposite must necessarily come into existence, and the opposite of man is woman.” Aristotle clearly superimposed man as the more important figure in men and women but presents an almost Qi like