Systole heart beats—is cued by messages from the brain, reflecting the brain's responses to conditions of the body, such as pain, emotional stress, level of activity, and to ambient conditions including external temperature, time of day, etc. Electrical systole opens voltage-gated sodium, potassium and calcium channels in cells of myocardium tissue. Subsequently, a rise in intracellular calcium triggers the interaction of actin and myosin in the presence of ATP which generates mechanical force in the cells in the form of muscular contraction, or mechanical systole. The contractions generate intra-ventricular pressure, which is increased until it exceeds the external, residual pressures in
History of beliefs about the human body is important to understanding histories of coercion and control, sex and gender, and other important but culturally varied aspects of human experience. Another prominent voice in the field at the same time was Caroline Walker Bynum, whose 1988 "Holy Feast and Holy Fast" became a landmark study. Both Bynum and Porter noted that during the 1980s Western history of the body research drew on post-structuralist thought, such as Michel Foucault's ideas of biopolitics and biopower, which emphasised that state power is not abstract, but exercised through and over human bodies. But both expressed a concern that research was focusing too