Otic vesicle constricts to form the canalis reuniens. The central part of the otic vesicle represents the membranous vestibule, and is subdivided by a constriction into a smaller ventral part, the saccule, and a larger dorsal and posterior part, the utricle. The dorsal component of the inner ear also consists of what will become the semicircular canals. The utricle and saccule communicate with each other by means of a Y-shaped canal. The FGF, Bmp, Wnt and Pax genes are likely to be involved in otic induction. FGF and BMP signals help control patterning in the early otic vesicle. Fgf3 and Fgf10 are
History of beliefs about the human body as imbalances of the 4 fluids of the body. Aristotle was unable to dissect humans but did so to many animals and was a early founder of comparative anatomy. Aristotle did contend quasi spiritual manifestations of the body principally through sexual distinctions. He wrote that the sex of humans: “is determined by the male principle already contained in the semen. If this is not strong enough, then the opposite must necessarily come into existence, and the opposite of man is woman.” Aristotle clearly superimposed man as the more important figure in men and women but presents an almost Qi like