Otic polyp to the external auditory canal if there is tympanic membrane perforation. Otic polyp An otic polyp (also called aural polyp) is a benign proliferation of chronic inflammatory cells associated with granulation tissue, in response to a longstanding inflammatory process of the middle ear. Patients usually present with otorrhea, conductive hearing loss, and otalgia, while bleeding and a sensation of a mass are much less common. Although imaging is not required to yield a diagnosis, it may be obtained to exclude other disorders, such as a concurrent cholesteatoma. By gross description, there is usually a solitary, polypoid, reddish mass behind an
Otic vesicle suggested to play a role in otic induction in mice, as were Msx genes suggested to play a role in otic vesicle formation in chicks. Pax8 is expressed during the entirety of otic vesicle formation. Other genes found in the otic vesicle across species that may play a role in patterning include Hmx, Fox, Dlx, and Gbx genes. Formation of the otic vesicle has been studied extensively in developmental model organisms including chick, Xenopus, zebrafish, axolotyl, & mouse. The transition from the otic placode to the otic vesicle occurs during the 19th somite stage in Zebrafish, Xenopus, and chick. In