Otic vesicle chick, invagination of the otic placode occurs passively due to the movements of the surrounding placode. The otic placode in zebrafish, on the other hand, occurs by cavitation; the ectodermal placode condenses and forms an ovoid ball directly below the embryo surface. Otic vesicle formation occurs later, during the 25-30 somite stage in mice. Otic vesicle Otic vesicle, or auditory vesicle, consists of either of the two sac-like invaginations formed and subsequently closed off during embryonic development. It is part of the neural ectoderm, which will develop into the membranous labyrinth of the inner ear. This labyrinth is a continuous
The Anatomy of Melancholy melancholia (which includes, although it is not limited to, what is now termed clinical depression). Although presented as a medical text, "The Anatomy of Melancholy" is as much a "sui generis" work of literature as it is a scientific or philosophical text, and Burton addresses far more than his stated subject. In fact, the "Anatomy" uses melancholy as the lens through which all human emotion and thought may be scrutinized, and virtually the entire contents of a 17th-century library are marshalled into service of this goal. It is encyclopedic in its range and reference. In his satirical preface to the