Domingo Liotta and Surgery in 1953. In 1955, he developed a technique for early diagnosis of tumors in the pancreas and ampulla of Vater (Pour le diagnostic des tumeurs du pancreas: La duodenographie hypotonique. Lyon Chirurgical, 1955). Liotta continued his medical career at the University of Lyon (France) at the "Pierre Mallet-Guy's" General Surgery Service. Then, he trained in thoracic and cardiac surgery, with Professors Paul Santy and Pierre Marion in Lyon France. His early works in the artificial heart are from 1958 in Córdoba, Argentina, where he developed an early prototype successfully used in small animals. After publishing the results of
Human artificial chromosome Human artificial chromosome A human artificial chromosome (HAC) is a microchromosome that can act as a new chromosome in a population of human cells. That is, instead of 46 chromosomes, the cell could have 47 with the 47th being very small, roughly 6–10megabases (Mb) in size instead of 50–250Mb for natural chromosomes, and able to carry new genes introduced by human researchers. Ideally, researchers could integrate different genes that perform a variety of functions, including disease defense. Alternative methods of creating transgenes, such as utilizing yeast artificial chromosomes and bacterial artificial chromosomes, lead to unpredictable problems. The genetic material introduced