Blood bone marrow in a process called hematopoiesis, which includes erythropoiesis, the production of red blood cells; and myelopoiesis, the production of white blood cells and platelets. During childhood, almost every human bone produces red blood cells; as adults, red blood cell production is limited to the larger bones: the bodies of the vertebrae, the breastbone (sternum), the ribcage, the pelvic bones, and the bones of the upper arms and legs. In addition, during childhood, the thymus gland, found in the mediastinum, is an important source of T lymphocytes. The proteinaceous component of blood (including clotting proteins) is produced predominantly by
Generative tissue becoming a living tissue. To date, the types of gTissue created can be characterized as variants of soft connective tissues including dermis, tendon, ligament, and fascia. Initially the cell-free ECM biomaterial is implanted and progressively adopted by the host. Immediately upon surgical implantation, the porous material becomes soaked in blood. This seeds the material with a population of circulating stem cells, and growth factors to support gTissue development. As generation progresses, the growth factors, cytokines, and fibrin provisional matrix signals host cells to repopulate the matrix. To support the metabolic activity of these cells, a vascular network is simultaneously created