Domingo Liotta University College of Medicine, Houston, Texas. 1962-64: Advanced Research Fellow of the American Heart Association. 1963-69: Co-Director of the Baylor-Rice Artificial Heart Program shared with Michael E. DeBakey and C. William Hall. Houston, Texas. 1964-71: Assistant Professor of Surgery, Baylor University College of Medicine, Chairman of the Department: Dr. Michael E. DeBakey, Houston, Texas. 1970-71: Director of Surgical Research, Texas Heart Institute, Chief of Cardiovascular Service Denton A. Cooley, Houston, Texas. 1971-74: Surgeon-in-Chief, Carlos Durand Public Hospital, Buenos Aires, Argentina. 1971-90: Surgeon-in-Chief, Service of Cardiovascular Surgery, Italian Hospital of Buenos Aires, Argentina. 1973-74: Secretary of State for Public Health, Argentina.
Human artificial chromosome benefits of HACs, namely their ability to stably contain extremely large genomic fragments. Researchers incorporated the 2.4Mb dystrophin gene, in which a mutation is a key causal element of Duchenne muscular dystrophy. The resulting HAC was mitotically stable, and correctly expressed dystrophin in chimeric mice. Previous attempts at correctly expressing dystrophin have failed. Due to its large size, it has never before been successfully integrated into a vector. In 2010, a refined human artificial chromosome called 21HAC was reported. 21HAC is based on a stripped copy of human chromosome 21, producing a chromosome 5Mb in length. Truncation of chromosome 21