Isotone Isotone Two nuclides are isotones if they have the same neutron number "N", but different proton number "Z". For example, boron-12 and carbon-13 nuclei both contain 7 neutrons, and so are isotones. Similarly, S, Cl, Ar, K, and Ca nuclei are all isotones of 20 because they all contain 20 neutrons. Despite its similarity to the Greek for "same stretching", the term was formed by the German physicist K. Guggenheimer by changing the "p" in "isotope" from "p" for "proton" to "n" for "neutron". The largest numbers of observationally stable nuclides exist for isotones 50 (five: Kr, Sr, Y, Zr,
Hydrogen–deuterium exchange can be measured at atomic resolution quantitatively by neutron crystallography, and in real time if exchange is conducted during the diffraction experiment. High intensity neutron beams are generally generated by spallation at linac particle accelerators such as the Spallation Neutron Source. Neutrons diffract crystals similarly to X-rays and can be used for structural determination. Hydrogen atoms, with between one and zero electrons in a biological setting, diffract X-rays poorly and are effectively invisible under normal experimental conditions. Neutrons scatter from atomic nuclei, and are therefore capable of detecting hydrogen and deuterium atoms. Hydrogen atoms are routinely replaced with deuterium, which