Magic number (physics) from the work of Maria Mayer, the very strong evidence for the closed shells. It seemed a little like magic to him, and that is how the words 'Magic Numbers' were coined." Nuclei which have neutron number and proton (atomic) numbers each equal to one of the magic numbers are called "double magic", and are especially stable against decay. Examples of double magic isotopes include helium-4, oxygen-16, calcium-40, calcium-48, nickel-48, nickel-78, and lead-208. Double-magic effects may allow existence of stable isotopes which otherwise would not have been expected. An example is calcium-40, with 20 neutrons and 20 protons, which is
Hydrogen–deuterium exchange can be measured at atomic resolution quantitatively by neutron crystallography, and in real time if exchange is conducted during the diffraction experiment. High intensity neutron beams are generally generated by spallation at linac particle accelerators such as the Spallation Neutron Source. Neutrons diffract crystals similarly to X-rays and can be used for structural determination. Hydrogen atoms, with between one and zero electrons in a biological setting, diffract X-rays poorly and are effectively invisible under normal experimental conditions. Neutrons scatter from atomic nuclei, and are therefore capable of detecting hydrogen and deuterium atoms. Hydrogen atoms are routinely replaced with deuterium, which