Free fatty acid receptor 2 Free fatty acid receptor 2 Free fatty acid receptor 2 (FFAR2) is a G-protein coupled receptor encoded by the FFAR2 gene. FFAR2 mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells. FFAR2 transcription is regulated by the XBP1 transcription factor which binds to the core promoter. Mouse studies utilizing Ffar2 gene deletions have implicated the receptor in the regulation of energy metabolism and immune responses. Short Chain Fatty Acids (SCFA's) generated in the processing of fiber by intestinal microbiota act as ligands for the receptor and can affect neutrophil chemotaxis. However, discrepancies
The Bones of What You Believe their neon-Eighties visions are far from retro pose-striking." Barry Nicolson of the "NME" praised the album's "great songwriting" and felt that "while not every track has the immediacy of 'Lies' or 'Recover', there's not a weak one among them." Heather Phares of AllMusic wrote, "Even on the darkest moments, such as 'Lies' or 'Science/Visions,' there's a disarming emotional directness to "The Bones of What You Believe" that makes it a unique, fully realized take on a style that seemed close to being played out." Ally Carnwath of "The Observer" commented that Chvrches are "more robust and melodic than arty peers