Domingo Liotta shortly thereafter. 1962 (May): Prolonged assisted circulation during and after cardiac and aortic surgery. Prolonged partial left ventricular bypass by means of intracorporeal circulation. It was selected as Finalist for the Young Investigators´ Contest Award (Denver) of the American College of Cardiology. 1964: Annual Award, Southwestern Surgical Society, USA. Shared with C. William Hall and Michael E. DeBakey.1968: Golden Eagle Award, Council of International Nontheatrical Events, USA, shared with Denton A. Cooley, Robert Bloodwell, and Grady Hallman. 1969: Award of Merit, American Medical Association shared with Denton A. Cooley, MD. 1969: Decoration of the Institute of Spanish Culture, Madrid, Spain.
Human artificial chromosome benefits of HACs, namely their ability to stably contain extremely large genomic fragments. Researchers incorporated the 2.4Mb dystrophin gene, in which a mutation is a key causal element of Duchenne muscular dystrophy. The resulting HAC was mitotically stable, and correctly expressed dystrophin in chimeric mice. Previous attempts at correctly expressing dystrophin have failed. Due to its large size, it has never before been successfully integrated into a vector. In 2010, a refined human artificial chromosome called 21HAC was reported. 21HAC is based on a stripped copy of human chromosome 21, producing a chromosome 5Mb in length. Truncation of chromosome 21