Osmotic nephrosis Osmotic nephrosis Osmotic nephrosis refers to structural changes that occur at the cellular level in the human kidney. Cells, primarily of the straight proximal tubule, swell due to the formation of large vacuoles in the cytoplasm. These vacuoles occur in the presence of large amounts of certain solutes circulating in the tubules. However, despite the condition's name, the solutes do not cause change through osmotic forces but through pinocytosis. Once inside the cytoplasm, pinocytic vacuoles combine with each other and with lysosomes to form large vacuoles that appear transparent under microscopic examination. There may be no symptomatic presentation with this
Degeneration theory government circles. The psychiatrist Henry Maudsley initially argued that degenerate family lines would die out with little social consequence, but later became more pessimistic about the effects of degeneration on the British population. In the "fin-de-siècle" period, Max Nordau scored an unexpected success with his bestselling "Degeneration" (1892). Sigmund Freud met Nordau in 1885 while he was studying in Paris and was notably unimpressed by him and hostile to the degeneration concept. Degeneration fell from popular and fashionable favor around the time of the First World War, although some of its preoccupations persisted in the writings of the eugenicists and