Artificial heart valve was later changed to use silicone-coated material. The first implantation of mechanical heart valve to human was performed by Dr. Hufnagel on 11 September 1952, using the valve that he developed. This event accelerated the development of other artificial heart valves. Artificial heart valve An artificial heart valve is a device implanted in the heart of a patient with valvular heart disease. When one of the four heart valves malfunctions, the medical choice may be to replace the natural valve with an artificial valve. This requires open-heart surgery. Valves are integral to the normal physiological functioning of the human heart.
Artificial uterus membranes such as is used in "extracorporeal membrane oxygenation" (ECMO). There is also potential to grow a placenta using human endometrial cells. In 2002, it was announced that tissue samples from cultured endometrial cells removed from a human donor had successfully grown. The tissue sample was then engineered to form the shape of a natural uterus, and human embryos were then implanted into the tissue. The embryos correctly implanted into the artificial uterus' lining and started to grow. However, the experiments were halted after six days to stay within the permitted legal limits of in vitro fertilisation (IVF) legislation in