Osmotic nephrosis Osmotic nephrosis Osmotic nephrosis refers to structural changes that occur at the cellular level in the human kidney. Cells, primarily of the straight proximal tubule, swell due to the formation of large vacuoles in the cytoplasm. These vacuoles occur in the presence of large amounts of certain solutes circulating in the tubules. However, despite the condition's name, the solutes do not cause change through osmotic forces but through pinocytosis. Once inside the cytoplasm, pinocytic vacuoles combine with each other and with lysosomes to form large vacuoles that appear transparent under microscopic examination. There may be no symptomatic presentation with this
Transneuronal degeneration monkeys to determine if this degeneration would lead to loss of neurons. It was the first experiment done on adult animals to show evidence of loss of neurons after one year, a long survival period for those affected cells. The degeneration led to cell shrinkage and cell death, and these symptoms were more profound after one year than during the first four months. Another study being done is on rats in which the olfactory bulb is removed has resulted in neurons in the primary olfactory cortex becoming argyrophilic in silver infused preparations. This allows the researchers to view the cells