Domingo Liotta and Surgery in 1953. In 1955, he developed a technique for early diagnosis of tumors in the pancreas and ampulla of Vater (Pour le diagnostic des tumeurs du pancreas: La duodenographie hypotonique. Lyon Chirurgical, 1955). Liotta continued his medical career at the University of Lyon (France) at the "Pierre Mallet-Guy's" General Surgery Service. Then, he trained in thoracic and cardiac surgery, with Professors Paul Santy and Pierre Marion in Lyon France. His early works in the artificial heart are from 1958 in Córdoba, Argentina, where he developed an early prototype successfully used in small animals. After publishing the results of
Human artificial chromosome benefits of HACs, namely their ability to stably contain extremely large genomic fragments. Researchers incorporated the 2.4Mb dystrophin gene, in which a mutation is a key causal element of Duchenne muscular dystrophy. The resulting HAC was mitotically stable, and correctly expressed dystrophin in chimeric mice. Previous attempts at correctly expressing dystrophin have failed. Due to its large size, it has never before been successfully integrated into a vector. In 2010, a refined human artificial chromosome called 21HAC was reported. 21HAC is based on a stripped copy of human chromosome 21, producing a chromosome 5Mb in length. Truncation of chromosome 21