Osmotic nephrosis Osmotic nephrosis Osmotic nephrosis refers to structural changes that occur at the cellular level in the human kidney. Cells, primarily of the straight proximal tubule, swell due to the formation of large vacuoles in the cytoplasm. These vacuoles occur in the presence of large amounts of certain solutes circulating in the tubules. However, despite the condition's name, the solutes do not cause change through osmotic forces but through pinocytosis. Once inside the cytoplasm, pinocytic vacuoles combine with each other and with lysosomes to form large vacuoles that appear transparent under microscopic examination. There may be no symptomatic presentation with this
Transneuronal degeneration under electron microscopes and see that these cells rapidly degenerate. The first signs of degeneration seen after the removal of the bulb was mitochondrial swelling and then an increase in electron density in the cytoplasm. Nuclear changes are seen later in which chromatin condenses and the nucleolus becomes replaced with large clusters of electron dense material. Once the degeneration has advanced far enough, ribosomes begin to disperse throughout the cell. Some cells are then phagocytosed by astrocytes and microglia. This study showed that the most cells affected by the necrosis were not directly connected to the olfactory bulb, but were