Domingo Liotta Author of the Law 20748, The National System of Public Health. 1991-94: Surgeon-in-Chief, Cardiovascular Clinic Institute, Buenos Aires, Argentina. 1994-96: Secretary of State for Science and Technology and President of the National Council of Scientific and Technological Research (CONICET), Argentina. 1997–present: Dean of the School of Medicine, University of Morón, Argentina Member of numerous Medical Societies around the world. Owner of 12 patent inventions in USA, Argentina and France. Author of hundreds of scientific publications and scientific books. Author of medical humanism books in English and Spanish. Recently published his autobiography,"Amazing Adventures of a Heart Surgeon. The Artificial Heart: The
Human artificial chromosome by these vectors not only leads to different expression levels, but the inserts also disrupt the original genome. HACs differ in this regard, as they are entirely separate chromosomes. This separation from existing genetic material assumes that no insertional mutants would arise. This stability and accuracy makes HACs preferable to other methods such as viral vectors, YACs and BACs. HACs allow for delivery of more DNA (including promoters and copy-number variation) than is possible with viral vectors. Yeast artificial chromosomes and bacterial artificial chromosomes were created before human artificial chromosomes, which first appeared in 1997. HACs are useful in expression