Free fatty acid receptor 2 Free fatty acid receptor 2 Free fatty acid receptor 2 (FFAR2) is a G-protein coupled receptor encoded by the FFAR2 gene. FFAR2 mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells. FFAR2 transcription is regulated by the XBP1 transcription factor which binds to the core promoter. Mouse studies utilizing Ffar2 gene deletions have implicated the receptor in the regulation of energy metabolism and immune responses. Short Chain Fatty Acids (SCFA's) generated in the processing of fiber by intestinal microbiota act as ligands for the receptor and can affect neutrophil chemotaxis. However, discrepancies
Soft tissue sarcoma in cats and dogs gather as much information as possible regarding the tumor's tissue origin, size, site, histologic grade (level of aggressiveness) and whether it has spread to other organs. To definitively confirm the diagnosis of a soft-tissue sarcoma, the veterinarian will have to perform biopsy for histopathologic evaluation. Additional tests are performed in order to evaluate how advanced the cancer is. These tests generally involve blood and serum biochemical tests, chest X-rays to check for metastasis to the lungs and imaging studies [e.g. ultrasound, computed tomography (CT) or magnetic resonance imaging (MRI)] to evaluate the extent of the disease. There are three main