Metal ions in aqueous solution radial distribution function. In contrast to X-ray diffraction, neutrons are scatted by nuclei and there is no relationship with atomic number. Indeed, use can be made of the fact that different isotopes of the same element can have widely different scattering powers. In a classic experiment, measurements were made on four nickel chloride solutions using the combinations of Ni, Ni, Cl and Cl isotopes to yield a very detailed picture of cation and anion solvation. Data for a number of metal salts show some dependence on the salt concentration. Most of these data refer to concentrated solutions in which there
Hydrogen–deuterium exchange can be measured at atomic resolution quantitatively by neutron crystallography, and in real time if exchange is conducted during the diffraction experiment. High intensity neutron beams are generally generated by spallation at linac particle accelerators such as the Spallation Neutron Source. Neutrons diffract crystals similarly to X-rays and can be used for structural determination. Hydrogen atoms, with between one and zero electrons in a biological setting, diffract X-rays poorly and are effectively invisible under normal experimental conditions. Neutrons scatter from atomic nuclei, and are therefore capable of detecting hydrogen and deuterium atoms. Hydrogen atoms are routinely replaced with deuterium, which