Nephrosis Nephrosis Nephrosis is any of various forms of kidney disease (nephropathy). In an old and broad sense of the term, it is any nephropathy, but in current usage the term is usually restricted to a narrower sense of nephropathy without inflammation or neoplasia, in which sense it is distinguished from nephritis, which involves inflammation. It is also defined as any purely degenerative disease of the renal tubules. Nephrosis is characterized by a set of signs called the nephrotic syndrome. Nephrosis can be a primary disorder or can be secondary to another disorder. Nephrotic complications of another disorder can coexist with
Transneuronal degeneration outline becomes more pronounced. In axons, similar effects can be seen. There is swelling in mitochondria and other membrane bound organelles. There is also a marked increase in cytoplasmic granularity and the dense packing of the neurotubules. Despite these alterations, synaptic specializations appear unchanged. There are varying degrees of degeneration. In mild degeneration the cytoplasmic areas shrinks and increases in density and mitochondria swell. However, the endomplasmic reticulum and the golgi apparatuses appear unchanged. The nuclear membrane appears intact, but there is some loss in differentiation in nuclear material. In more severely affected cells, the separation between the cytoplasm and