Reticular connective tissue Reticular connective tissue Reticular connective tissue is a type of connective tissue with a network of reticular fibers, made of type III collagen ("reticulum" = net or network). Reticular fibers are not unique to reticular connective tissue, but only in this type are they dominant. Reticular fibers are synthesized by special fibroblasts called reticular cells. The fibers are thin branching structures. Reticular connective tissue is found around the kidney, the spleen, and lymph nodes, Peyer's patches as well as in bone marrow. The fibers form a soft skeleton (stroma) to support the lymphoid organs (lymph node stromal cells, red bone
Tissue remodeling In the proliferation phase, inflammatory cells die by apoptosis, being replaced by myofibroblasts which produce large amounts of collagen. In the maturation phase, myofibroblast numbers are reduced by apoptosis, allowing for infiltration by endothelial cells (for blood vessels) and cardiomyocytes (heart tissue cells). Usually, however, much of the tissue remodeling is pathological, resulting in a large amount of fibrous tissue. By contrast, aerobic exercise can produce beneficial cardiac tissue remodeling in those suffering from left ventricular hypertrophy. Vascular remodeling refers to a compensatory change in blood vessel walls due to plaque growth. Vascular expansion is called positive remodeling, whereas vascular