Whole number rule called the neutron. The fact that the atomic nucleus is composed of protons and neutrons was rapidly accepted and Chadwick was awarded the Nobel Prize in Physics in 1935 for his discovery. The modern form of the whole number rule is that the atomic mass of a given elemental isotope is approximately the mass number (number of protons plus neutrons) times an atomic mass unit (approximate mass of a proton, neutron, or hydrogen-1 atom). This rule predicts the atomic mass of nuclides and isotopes with an error of at most 1%. Whole number rule The whole number rule states that
Hydrogen–deuterium exchange can be measured at atomic resolution quantitatively by neutron crystallography, and in real time if exchange is conducted during the diffraction experiment. High intensity neutron beams are generally generated by spallation at linac particle accelerators such as the Spallation Neutron Source. Neutrons diffract crystals similarly to X-rays and can be used for structural determination. Hydrogen atoms, with between one and zero electrons in a biological setting, diffract X-rays poorly and are effectively invisible under normal experimental conditions. Neutrons scatter from atomic nuclei, and are therefore capable of detecting hydrogen and deuterium atoms. Hydrogen atoms are routinely replaced with deuterium, which