Domingo Liotta Domingo Liotta Domingo Santo Liotta (born November 29, 1924) is a pioneer of heart surgery, creator of multiple cardiac prostheses including the first total artificial heart used in a human being. Domingo Santo Liotta son of Italian immigrants, was born in the city of Diamante, Entre Rios, Argentina on November 29, 1924. He completed his elementary school at his hometown at "Independencia School", and his high school at the "Justo Jose de Urquiza School" in Concepcion del Uruguay, Entre Rios. In 1949, he graduated as a Medical Doctor at National University of Córdoba (Argentina). He received a doctorate in Medicine
Human artificial chromosome resulted in a human artificial chromosome that is mitotically stable. 21HAC was also able to be transferred into cells from a variety of species (mice, chickens, humans). Using 21HAC, researchers were able to insert a herpes simplex virus- thymidine kinase coding gene into tumor cells. This "suicide gene" is required to activate many antiviral medications. These targeted tumor cells were successfully, and selectively, terminated by the antiviral drug ganciclovir in a population including healthy cells. This research opens a variety of opportunities for using HACs in gene therapy. In 2011, researchers formed a human artificial chromosome by truncating chromosome 14.