Domingo Liotta Author of the Law 20748, The National System of Public Health. 1991-94: Surgeon-in-Chief, Cardiovascular Clinic Institute, Buenos Aires, Argentina. 1994-96: Secretary of State for Science and Technology and President of the National Council of Scientific and Technological Research (CONICET), Argentina. 1997–present: Dean of the School of Medicine, University of Morón, Argentina Member of numerous Medical Societies around the world. Owner of 12 patent inventions in USA, Argentina and France. Author of hundreds of scientific publications and scientific books. Author of medical humanism books in English and Spanish. Recently published his autobiography,"Amazing Adventures of a Heart Surgeon. The Artificial Heart: The
Human artificial chromosome artificial chromosome vectors. The first is to create a small minichromosome by altering a natural human chromosome. This is accomplished by truncating the natural chromosome, followed by the introduction of unique genetic material via the Cre-Lox system of recombination. The second method involves the literal creation of a novel chromosome "de novo". Progress regarding "de novo" HAC formation has been limited, as many large genomic fragments will not successfully integrate into "de novo" vectors. Another factor limiting "de novo" vector formation is limited knowledge of what elements are required for construction, specifically centromeric sequences. A 2009 study has shown additional