Osmotic nephrosis Osmotic nephrosis Osmotic nephrosis refers to structural changes that occur at the cellular level in the human kidney. Cells, primarily of the straight proximal tubule, swell due to the formation of large vacuoles in the cytoplasm. These vacuoles occur in the presence of large amounts of certain solutes circulating in the tubules. However, despite the condition's name, the solutes do not cause change through osmotic forces but through pinocytosis. Once inside the cytoplasm, pinocytic vacuoles combine with each other and with lysosomes to form large vacuoles that appear transparent under microscopic examination. There may be no symptomatic presentation with this
Organ in the Jacobikerk at Uithuizen and Pedal including the housing. Three lost registers have been completely reconstructed, including the façade pipes with gilded labia, and three registers partially reconstructed. The 2011 state of the organ shows the original disposition: Organ in the Jacobikerk at Uithuizen The Jacobikerk organ in Uithuizen in the Dutch province of Groningen was built in 1701 by Arp Schnitger. It has 28 stops (registers) which are distributed on two manuals and pedal. The instrument is one of the best preserved Schnitger organs. The organ has been used as a template for newly-built organs in the 20th century and for the reconstruction