Domingo Liotta his studies, Dr. Liotta was hired at Baylor College of Medicine in Houston Texas as Director of the Artificial Heart Program by Dr. Michael E. DeBakey in 1961. 1961(December): First conception of the prolonged mechanical assist circulation in the treatment of Cardiogenic Shock Postcardiotomy. 1963 (July 19): Left Ventricular Assist Device (LVAD) in a patient in cardiogenic shock postcardiotomy, Domingo Liotta and E. Stanley Crawford at the Methodist Hospital in Houston, Texas. First clinical use. The original clinical prototype is displayed at the Smithsonian Institution, Washington, D.C.. 1966 (April 21): Liotta-DeBakey LVAD implanted in a cardiogenic shock postcardiotomy patient, Methodist
Human artificial chromosome benefits of HACs, namely their ability to stably contain extremely large genomic fragments. Researchers incorporated the 2.4Mb dystrophin gene, in which a mutation is a key causal element of Duchenne muscular dystrophy. The resulting HAC was mitotically stable, and correctly expressed dystrophin in chimeric mice. Previous attempts at correctly expressing dystrophin have failed. Due to its large size, it has never before been successfully integrated into a vector. In 2010, a refined human artificial chromosome called 21HAC was reported. 21HAC is based on a stripped copy of human chromosome 21, producing a chromosome 5Mb in length. Truncation of chromosome 21