Nephrosis Nephrosis Nephrosis is any of various forms of kidney disease (nephropathy). In an old and broad sense of the term, it is any nephropathy, but in current usage the term is usually restricted to a narrower sense of nephropathy without inflammation or neoplasia, in which sense it is distinguished from nephritis, which involves inflammation. It is also defined as any purely degenerative disease of the renal tubules. Nephrosis is characterized by a set of signs called the nephrotic syndrome. Nephrosis can be a primary disorder or can be secondary to another disorder. Nephrotic complications of another disorder can coexist with
Transneuronal degeneration in the fornix, mammillary bodies, and contralateral cerebellum. It has recently been shown that transneuronal degeneration can also be caused after respiratory chain-deficient neurons develop from "de novo" mitochondrial DNA mutations, which are normally associated with mammalian ageing. The respiratory chain-deficient neurons have adverse effect on normal adjacent neurons, inducing death by means of transneuronal degeneration. Transneuronal degeneration in these cases is accelerated during the ageing process since other cellular maintenance systems are already damaged as well as in the presence of mitochondrial disease, where non-neuronal cells like glial cells and astrocytes also have respiratory chain deficiency. This also means