Osmotic nephrosis Osmotic nephrosis Osmotic nephrosis refers to structural changes that occur at the cellular level in the human kidney. Cells, primarily of the straight proximal tubule, swell due to the formation of large vacuoles in the cytoplasm. These vacuoles occur in the presence of large amounts of certain solutes circulating in the tubules. However, despite the condition's name, the solutes do not cause change through osmotic forces but through pinocytosis. Once inside the cytoplasm, pinocytic vacuoles combine with each other and with lysosomes to form large vacuoles that appear transparent under microscopic examination. There may be no symptomatic presentation with this
Degeneration theory Blumenbach and Robert Knox. From the 1850s, it became influential in psychiatry through the writings of Bénédict Morel, and in criminology with Cesare Lombroso. By the 1890s, in the work of Max Nordau and others, degeneration became a more general concept in social commentary. The meaning of "degeneration" was poorly defined, but can be described as an organism's change from a more complex to a simpler, less differentiated form, and is associated with 19th century conceptions of biological devolution. Although rejected by Charles Darwin, the theory's application to the social sciences was supported by some evolutionary biologists, most notably Ernst