Rosetta Stone Rosetta Stone The Rosetta Stone is a granodiorite stele, found in 1799, inscribed with three versions of a decree issued at Memphis, Egypt in 196 BC during the Ptolemaic dynasty on behalf of King Ptolemy V. The top and middle texts are in Ancient Egyptian using hieroglyphic script and Demotic script, respectively, while the bottom is in Ancient Greek. As the decree has only minor differences between the three versions, the Rosetta Stone proved to be the key to deciphering Egyptian hieroglyphs, thereby opening a window into ancient Egyptian history. The stone, carved during the Hellenistic period, is believed to
Rosetta@home design novel homing endonuclease proteins, which could eradicate "Anopheles gambiae" or otherwise render the mosquito unable to transmit malaria. Being able to model and alter protein–DNA interactions specifically, like those of homing endonucleases, gives computational protein design methods like Rosetta an important role in gene therapy (which includes possible cancer treatments). Originally introduced by the Baker laboratory in 1998 as an "ab initio" approach to structure prediction, Rosetta has since branched into several development streams and distinct services. The Rosetta platform derives its name from the Rosetta Stone, as it attempts to decipher the structural "meaning" of proteins' amino acid