Denton Cooley 1960s. He and his colleagues worked on developing new artificial heart valves from 1962 to 1967; during that period, mortality for heart valve transplants fell from 70% to 8%. In 1969, he became the first heart surgeon to implant an artificial heart designed by Domingo Liotta in a man, Haskell Karp, who lived for 65 hours. The next year, in 1970, "he performed the first implantation of an artificial heart in a human when no heart replacement was immediately available." Cooley's interests included basketball, which he played in high school and as a three-year letterman for the UT men's basketball
Human artificial chromosome benefits of HACs, namely their ability to stably contain extremely large genomic fragments. Researchers incorporated the 2.4Mb dystrophin gene, in which a mutation is a key causal element of Duchenne muscular dystrophy. The resulting HAC was mitotically stable, and correctly expressed dystrophin in chimeric mice. Previous attempts at correctly expressing dystrophin have failed. Due to its large size, it has never before been successfully integrated into a vector. In 2010, a refined human artificial chromosome called 21HAC was reported. 21HAC is based on a stripped copy of human chromosome 21, producing a chromosome 5Mb in length. Truncation of chromosome 21