Domingo Liotta Author of the Law 20748, The National System of Public Health. 1991-94: Surgeon-in-Chief, Cardiovascular Clinic Institute, Buenos Aires, Argentina. 1994-96: Secretary of State for Science and Technology and President of the National Council of Scientific and Technological Research (CONICET), Argentina. 1997–present: Dean of the School of Medicine, University of Morón, Argentina Member of numerous Medical Societies around the world. Owner of 12 patent inventions in USA, Argentina and France. Author of hundreds of scientific publications and scientific books. Author of medical humanism books in English and Spanish. Recently published his autobiography,"Amazing Adventures of a Heart Surgeon. The Artificial Heart: The
Human artificial chromosome benefits of HACs, namely their ability to stably contain extremely large genomic fragments. Researchers incorporated the 2.4Mb dystrophin gene, in which a mutation is a key causal element of Duchenne muscular dystrophy. The resulting HAC was mitotically stable, and correctly expressed dystrophin in chimeric mice. Previous attempts at correctly expressing dystrophin have failed. Due to its large size, it has never before been successfully integrated into a vector. In 2010, a refined human artificial chromosome called 21HAC was reported. 21HAC is based on a stripped copy of human chromosome 21, producing a chromosome 5Mb in length. Truncation of chromosome 21