Domingo Liotta his studies, Dr. Liotta was hired at Baylor College of Medicine in Houston Texas as Director of the Artificial Heart Program by Dr. Michael E. DeBakey in 1961. 1961(December): First conception of the prolonged mechanical assist circulation in the treatment of Cardiogenic Shock Postcardiotomy. 1963 (July 19): Left Ventricular Assist Device (LVAD) in a patient in cardiogenic shock postcardiotomy, Domingo Liotta and E. Stanley Crawford at the Methodist Hospital in Houston, Texas. First clinical use. The original clinical prototype is displayed at the Smithsonian Institution, Washington, D.C.. 1966 (April 21): Liotta-DeBakey LVAD implanted in a cardiogenic shock postcardiotomy patient, Methodist
Human artificial chromosome resulted in a human artificial chromosome that is mitotically stable. 21HAC was also able to be transferred into cells from a variety of species (mice, chickens, humans). Using 21HAC, researchers were able to insert a herpes simplex virus- thymidine kinase coding gene into tumor cells. This "suicide gene" is required to activate many antiviral medications. These targeted tumor cells were successfully, and selectively, terminated by the antiviral drug ganciclovir in a population including healthy cells. This research opens a variety of opportunities for using HACs in gene therapy. In 2011, researchers formed a human artificial chromosome by truncating chromosome 14.