Opuntia ficus-indica fruit and juice is due to betalains, (betanin and indicaxanthin). The plant also contains flavonoids, such as quercetin, isorhamnetin, and kaempferol. DNA analysis indicated "O. ficus-indica" was domesticated from "Opuntia" species native to central Mexico. The Codex Mendoza, and other early sources, show "Opuntia" cladodes, as well as cochineal dye (which needs cultivated "Opuntia"), in Aztec tribute rolls. The plant spread to many parts of the Americas in pre-Columbian times, and since Columbus, has spread to many parts of the world, especially the Mediterranean, where it has become naturalized. Opuntia ficus-indica Opuntia ficus-indica (prickly pear) is a species of cactus
Opuntia readily between species. This can make classification difficult, yielding a reticulate phylogeny where different species come together in hybridization. Also, not all species listed here may actually belong in this genus, meaning that "Opuntia" is not a monophyletic group. "Opuntia" also has a tendency for polyploidy. The ancestral diploid state was 2n=22, but many species are hexaploid (6n = 66) or octaploid (8n = 88). Chollas, now recognized to belong to the distinct genus "Cylindropuntia", are distinguished by having cylindrical, rather than flattened, stem segments with large barbed spines. The stem joints of several species, notably the jumping cholla ("Cylindropuntia