Bimodal volcanism of back-arc basin formation and in the products of both continental and oceanic hotspots (e.g. Yellowstone and the Canary Islands). Bimodal volcanism is normally explained as a result of partial melting of the crust, creating granitic magmas, during the emplacement of large volumes of relatively hot basaltic magma from a mantle source. The two magma types then form separate magma chambers giving rise to periodic eruption of both types of lava. Bimodal volcanism Bimodal volcanism is the eruption of both mafic and felsic lavas from a single volcanic centre with little or no lavas of intermediate composition. This type of
Substance P The sensory function of substance P is thought to be related to the transmission of pain information into the central nervous system. Substance P coexists with the excitatory neurotransmitter glutamate in primary afferents that respond to painful stimulation. Substance P and other sensory neuropeptides can be released from the peripheral terminals of sensory nerve fibers in the skin, muscle, and joints. It is proposed that this release is involved in neurogenic inflammation, which is a local inflammatory response to certain types of infection or injury. Unfortunately, the reasons why NK1RAs have failed as efficacious analgesics in well-conducted clinical proof of