Robert Jarvik animal in the lab for 10 days. Kolff assigned Jarvik to design a new heart that would overcome the problems of the Kwan-Gett heart, eventually culminating with the Jarvik-7 device. In 1982, the team carried out an artificial heart implant - the second ever, 13 years after Domingo Liotta and Denton Cooley's first in 1969. William DeVries first implanted the Jarvik-7 into retired dentist Barney Clark at the University of Utah on December 2, 1982. Clark required frequent visits to the hospital for the next 112 days, after which he died. During frequent press conferences to update the patient's condition,
Human artificial chromosome Human artificial chromosome A human artificial chromosome (HAC) is a microchromosome that can act as a new chromosome in a population of human cells. That is, instead of 46 chromosomes, the cell could have 47 with the 47th being very small, roughly 6–10megabases (Mb) in size instead of 50–250Mb for natural chromosomes, and able to carry new genes introduced by human researchers. Ideally, researchers could integrate different genes that perform a variety of functions, including disease defense. Alternative methods of creating transgenes, such as utilizing yeast artificial chromosomes and bacterial artificial chromosomes, lead to unpredictable problems. The genetic material introduced