Artificial heart Artificial heart An artificial heart is a device that replaces the heart. Artificial hearts are typically used to bridge the time to heart transplantation, or to permanently replace the heart in case heart transplantation is impossible. Although other similar inventions preceded it from the late 1940s, the first artificial heart to be successfully implanted in a human was the Jarvik-7 in 1982, designed by a team including Willem Johan Kolff and Robert Jarvik. An artificial heart is distinct from a ventricular assist device (VAD) designed to support a failing heart. It is also distinct from a cardiopulmonary bypass machine, which
Human artificial chromosome benefits of HACs, namely their ability to stably contain extremely large genomic fragments. Researchers incorporated the 2.4Mb dystrophin gene, in which a mutation is a key causal element of Duchenne muscular dystrophy. The resulting HAC was mitotically stable, and correctly expressed dystrophin in chimeric mice. Previous attempts at correctly expressing dystrophin have failed. Due to its large size, it has never before been successfully integrated into a vector. In 2010, a refined human artificial chromosome called 21HAC was reported. 21HAC is based on a stripped copy of human chromosome 21, producing a chromosome 5Mb in length. Truncation of chromosome 21