Argentina recipient, discovered the role of pituitary hormones in regulating glucose in animals, and shared the Nobel Prize in Physiology or Medicine in 1947. Luis Leloir discovered how organisms store energy converting glucose into glycogen and the compounds which are fundamental in metabolizing carbohydrates, receiving the Nobel Prize in Chemistry in 1970. César Milstein did extensive research in antibodies, sharing the Nobel Prize in Physiology or Medicine in 1984. Argentine research has led to treatments for heart diseases and several forms of cancer. Domingo Liotta designed and developed the first artificial heart that was successfully implanted in a human being in
Human artificial chromosome benefits of HACs, namely their ability to stably contain extremely large genomic fragments. Researchers incorporated the 2.4Mb dystrophin gene, in which a mutation is a key causal element of Duchenne muscular dystrophy. The resulting HAC was mitotically stable, and correctly expressed dystrophin in chimeric mice. Previous attempts at correctly expressing dystrophin have failed. Due to its large size, it has never before been successfully integrated into a vector. In 2010, a refined human artificial chromosome called 21HAC was reported. 21HAC is based on a stripped copy of human chromosome 21, producing a chromosome 5Mb in length. Truncation of chromosome 21