Stratovolcano Stratovolcano A stratovolcano, also known as a composite volcano, is a conical volcano built up by many layers (strata) of hardened lava, tephra, pumice and ash. Unlike shield volcanoes, stratovolcanoes are characterized by a steep profile with a summit crater and periodic intervals of explosive eruptions and effusive eruptions, although some have collapsed summit craters called calderas. The lava flowing from stratovolcanoes typically cools and hardens before spreading far due to high viscosity. The magma forming this lava is often felsic, having high-to-intermediate levels of silica (as in rhyolite, dacite, or andesite), with lesser amounts of less-viscous mafic magma. Extensive
Substance P The sensory function of substance P is thought to be related to the transmission of pain information into the central nervous system. Substance P coexists with the excitatory neurotransmitter glutamate in primary afferents that respond to painful stimulation. Substance P and other sensory neuropeptides can be released from the peripheral terminals of sensory nerve fibers in the skin, muscle, and joints. It is proposed that this release is involved in neurogenic inflammation, which is a local inflammatory response to certain types of infection or injury. Unfortunately, the reasons why NK1RAs have failed as efficacious analgesics in well-conducted clinical proof of