Umbilical cord from and contains remnants of the yolk sac and allantois. It forms by the fifth week of development, replacing the yolk sac as the source of nutrients for the embryo. The cord is not directly connected to the mother's circulatory system, but instead joins the placenta, which transfers materials to and from the maternal blood without allowing direct mixing. The length of the umbilical cord is approximately equal to the crown-rump length of the fetus throughout pregnancy. The umbilical cord in a full term neonate is usually about 50 centimeters (20 in) long and about 2 centimeters (0.75 in) in
Percutaneous umbilical cord blood sampling preexisting defects and abnormalities. While ultrasounds and color flow mapping can be used to avoid the umbilical artery and sample from the umbilical vein, the dilation makes the single umbilical artery easier to puncture. Blood flow in the umbilical artery is seen to be twice the normal amount from about 20 weeks on so the effects of a punctured umbilical artery during PUBS are more severe. Percutaneous umbilical cord blood sampling "For other uses see PUBS ( page)" Percutaneous umbilical cord blood sampling (PUBS), also called cordocentesis, fetal blood sampling, or umbilical vein sampling is a diagnostic genetic test that