Rosetta Stone Athanasius Kircher in the 17th, and Georg Zoëga in the 18th. The discovery of the Rosetta Stone in 1799 provided critical missing information, gradually revealed by a succession of scholars, that eventually allowed Jean-François Champollion to solve the puzzle that Kircher had called the riddle of the Sphinx. The Greek text on the Rosetta Stone provided the starting point. Ancient Greek was widely known to scholars, but they were not familiar with details of its use in the Hellenistic period as a government language in Ptolemaic Egypt; large-scale discoveries of Greek papyri were a long way in the future. Thus,
Rosetta@home design novel homing endonuclease proteins, which could eradicate "Anopheles gambiae" or otherwise render the mosquito unable to transmit malaria. Being able to model and alter protein–DNA interactions specifically, like those of homing endonucleases, gives computational protein design methods like Rosetta an important role in gene therapy (which includes possible cancer treatments). Originally introduced by the Baker laboratory in 1998 as an "ab initio" approach to structure prediction, Rosetta has since branched into several development streams and distinct services. The Rosetta platform derives its name from the Rosetta Stone, as it attempts to decipher the structural "meaning" of proteins' amino acid