Osmotic nephrosis condition, or it may confused with other nephrotic conditions such as Tubular calcineurin-inhibitor toxicity. Affected cells of the proximal tubule may be passed in the urine, but a kidney biopsy is the only sure way to make a diagnosis. Responsible exogenous solutes include sucrose-containing IVIg, mannitol, dextran, contrast dye, and hydroxyethyl starch. Prevention includes standard preventions for iatrogenic kidney damage. Osmotic nephrosis is usually reversible but can lead to chronic renal failure. Osmotic nephrosis Osmotic nephrosis refers to structural changes that occur at the cellular level in the human kidney. Cells, primarily of the straight proximal tubule, swell due to
Organ in the Jacobikerk at Uithuizen Organ in the Jacobikerk at Uithuizen The Jacobikerk organ in Uithuizen in the Dutch province of Groningen was built in 1701 by Arp Schnitger. It has 28 stops (registers) which are distributed on two manuals and pedal. The instrument is one of the best preserved Schnitger organs. The organ has been used as a template for newly-built organs in the 20th century and for the reconstruction of lost registers of other Schnitger organs. Bills for organ repairs dating from the second half of the 17th century are in evidence and point to the existence of an organ. However, Schnitger took