Prout's hypothesis being correct. Nevertheless, the rule was not found to predict isotope masses better than this for all isotopes, due mostly to mass-defects resulting from release of binding energy in atomic nuclei, when they are formed. Although all elements are the product of nuclear fusion of hydrogen into higher elements, it is now understood that atoms consist of both protons (hydrogen nuclei) and neutrons. The modern version of Prout's rule is that the atomic mass of an isotope of proton number (atomic number) "Z" and neutron number "N" is equal to sum of the masses of its constituent protons and neutrons,
Molecule as ethanol, for instance. Molecules with the same atoms in different arrangements are called isomers. Also carbohydrates, for example, have the same ratio (carbon:hydrogen:oxygen= 1:2:1) (and thus the same empirical formula) but different total numbers of atoms in the molecule. The molecular formula reflects the exact number of atoms that compose the molecule and so characterizes different molecules. However different isomers can have the same atomic composition while being different molecules. The empirical formula is often the same as the molecular formula but not always. For example, the molecule acetylene has molecular formula CH, but the simplest integer ratio of