Osmotic nephrosis condition, or it may confused with other nephrotic conditions such as Tubular calcineurin-inhibitor toxicity. Affected cells of the proximal tubule may be passed in the urine, but a kidney biopsy is the only sure way to make a diagnosis. Responsible exogenous solutes include sucrose-containing IVIg, mannitol, dextran, contrast dye, and hydroxyethyl starch. Prevention includes standard preventions for iatrogenic kidney damage. Osmotic nephrosis is usually reversible but can lead to chronic renal failure. Osmotic nephrosis Osmotic nephrosis refers to structural changes that occur at the cellular level in the human kidney. Cells, primarily of the straight proximal tubule, swell due to
Ballooning degeneration wispy/cobweb-like, while adipocyte-like cells have a clear cytoplasm or a vacuolated one. Ballooning degeneration is somewhat similar in appearance to feathery degeneration, which is associated with cholestasis, and also has cytoplasmic clearing and cell swelling. Ballooning degeneration In histopathology, ballooning degeneration, formally ballooning degeneration of hepatocytes, is a form of liver parenchymal cell (i.e. hepatocyte) death. The name is derived from the fact that the cells undergoing this form of cell death increase in size (balloon). It is generally considered a form of apoptosis, and is a descriptor used in the context of inflamed fatty liver (steatohepatitis) (which may be