Mount Pleasant Caldera rock. The Intercaldera Sequence comprises formations that crop out from overlying flows in triangularly shaped area, and includes thick volcanic ash (tuff), thick breccia layers, and intermediate to felsic igneous rocks that tend to intrude the above layers and are typically located along caldera margin faults. The Exocaldera Sequence contains ash flow tuffs, mafic lavas, alluvial redbeds, and porphyritic felsic lavas that are distributed across five different layers. The late Caldera-Fill Sequence contains rocks that are similar to those of the outflows of the other, older layers, and comprises two formations and two relatively minor intrusive lava flows. The volcanic
Substance P The sensory function of substance P is thought to be related to the transmission of pain information into the central nervous system. Substance P coexists with the excitatory neurotransmitter glutamate in primary afferents that respond to painful stimulation. Substance P and other sensory neuropeptides can be released from the peripheral terminals of sensory nerve fibers in the skin, muscle, and joints. It is proposed that this release is involved in neurogenic inflammation, which is a local inflammatory response to certain types of infection or injury. Unfortunately, the reasons why NK1RAs have failed as efficacious analgesics in well-conducted clinical proof of