Free fatty acid receptor 2 between the pathways activated by FFAR2 agonists in human cells and the equivalent murine counterparts have been observed. FFAR2 may interact with FFAR3 to form a FFAR2-FFAR3 receptor heteromer with signalling that is distinct from the parent homomers. Free fatty acid receptor 2 Free fatty acid receptor 2 (FFAR2) is a G-protein coupled receptor encoded by the FFAR2 gene. FFAR2 mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells. FFAR2 transcription is regulated by the XBP1 transcription factor which binds to the core promoter. Mouse studies utilizing Ffar2 gene deletions have implicated
Short-chain fatty acid colon health because it is the primary energy source for colonic cells. Short-chain fatty acid Short-chain fatty acids (SCFAs), also referred to as volatile fatty acids (VFAs), are fatty acids with less than six carbon atoms. Free SCFAs can cross the blood-brain barrier via monocarboxylate transporters. Short-chain fatty acids are produced when dietary fiber is fermented in the colon. Short-chain fatty acids and medium-chain fatty acids are primarily absorbed through the portal vein during lipid digestion, while long-chain fatty acids are packed into chylomicrons and enter lymphatic capillaries, and enter the blood first at the subclavian vein. Short-chain fatty acids