Isambard Kingdom Brunel to design Brunel Manor and its gardens to be his country home. He never saw the house or gardens finished, as he died before it was completed. Brunel, a heavy smoker, who had been diagnosed with Bright's disease (nephritis), suffered a stroke on 5 September 1859, just before the "Great Eastern" made her first voyage to New York. He died ten days later at the age of 53 and was buried, like his father, in Kensal Green Cemetery in London. He left behind his wife Mary and three children: Isambard Brunel Junior (1837–1902), Henry Marc Brunel (1842–1903) and Florence Mary
Isambard Owen Isambard Owen Sir (Herbert) Isambard Owen (28 December 1850 – 14 January 1927) was a British physician and university academic. He was the first Vice-Chancellor of the University of Bristol and a deputy Chancellor of the University of Wales. Owen was born in Chepstow in Monmouthshire, south Wales. At the time his father, William Owen, later chief engineer of the Great Western Railway, was building the South Wales Railway under Isambard Kingdom Brunel, from whom Isambard Owen received his unusual name. He was educated at The King's School, Gloucester, Rossall School and Downing College, Cambridge, where he read Natural Sciences.