Denton Cooley 1960s. He and his colleagues worked on developing new artificial heart valves from 1962 to 1967; during that period, mortality for heart valve transplants fell from 70% to 8%. In 1969, he became the first heart surgeon to implant an artificial heart designed by Domingo Liotta in a man, Haskell Karp, who lived for 65 hours. The next year, in 1970, "he performed the first implantation of an artificial heart in a human when no heart replacement was immediately available." Cooley's interests included basketball, which he played in high school and as a three-year letterman for the UT men's basketball
Artificial cell cells have been proposed as a non-viral vector by which genetically modified non-autologous cells are encapsulated and implanted to deliver recombinant proteins "in vivo". This type of immuno-isolation has been proven efficient in mice through delivery of artificial cells containing mouse growth hormone which rescued a growth-retardation in mutant mice. A few strategies have advanced to human clinical trials for the treatment of pancreatic cancer, lateral sclerosis and pain control. The first clinical use of artificial cells was in hemoperfusion by the encapsulation of activated charcoal. Activated charcoal has the capability of adsorbing many large molecules and has for a