Prout's hypothesis being correct. Nevertheless, the rule was not found to predict isotope masses better than this for all isotopes, due mostly to mass-defects resulting from release of binding energy in atomic nuclei, when they are formed. Although all elements are the product of nuclear fusion of hydrogen into higher elements, it is now understood that atoms consist of both protons (hydrogen nuclei) and neutrons. The modern version of Prout's rule is that the atomic mass of an isotope of proton number (atomic number) "Z" and neutron number "N" is equal to sum of the masses of its constituent protons and neutrons,
Neutron 1942) and the first nuclear weapon (Trinity, 1945). Free neutrons, while not directly ionizing atoms, cause ionizing radiation. As such they can be a biological hazard, depending upon dose. A small natural "neutron background" flux of free neutrons exists on Earth, caused by cosmic ray showers, and by the natural radioactivity of spontaneously fissionable elements in the Earth's crust. Dedicated neutron sources like neutron generators, research reactors and spallation sources produce free neutrons for use in irradiation and in neutron scattering experiments. Atomic nuclei are formed by a number of protons, Z the atomic number, and a number of neutrons,