Free fatty acid receptor 2 Free fatty acid receptor 2 Free fatty acid receptor 2 (FFAR2) is a G-protein coupled receptor encoded by the FFAR2 gene. FFAR2 mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells. FFAR2 transcription is regulated by the XBP1 transcription factor which binds to the core promoter. Mouse studies utilizing Ffar2 gene deletions have implicated the receptor in the regulation of energy metabolism and immune responses. Short Chain Fatty Acids (SCFA's) generated in the processing of fiber by intestinal microbiota act as ligands for the receptor and can affect neutrophil chemotaxis. However, discrepancies
The Bones of What You Believe such as Grimes and Purity Ring—choruses are foregrounded, synthy jabs pummel Lauren Mayberry's vocals, beats drop from satisfying heights—but Mayberry's lyrics also carry a subversive twist of angst and obsession." In a mixed review, Slant Magazine's Kevin Liedel remarked, "While the album has its fair share of sweet spots, the handful of capable melodies never quite balances out its bizarre impulses or the utter lack of thematic unity." Credits adapted from the liner notes of "The Bones of What You Believe". The Bones of What You Believe The Bones of What You Believe is the debut studio album by Scottish