Equine proximal enteritis the intestinal lumen. Inflammation of the intestine leads to the secretion of a large amounts of electrolytes, primarily sodium and chloride, into its lumen, resulting in the osmotic movement of water. The production of fluid is thought to be due to active hypersecretion, passive secretion of proteins secondary to damage to epithelium of the mucosa and capillaries, and a functional ileus which prevents removal of this fluid. Massive fluid production results in extensive reflux, usually produced at a rate of 50–100 mL/min, in addition to distention of the proximal small intestine, dehydration, and possible shock secondary to hypovolemia. Proximal enteritis
Clostridial necrotizing enteritis Clostridial necrotizing enteritis Clostridial necrotizing enteritis (CNE), also called enteritis necroticans and pigbel, is an often fatal type of food poisoning caused by a β-toxin of "Clostridium perfringens", Type C. It occurs in some developing countries, but was also documented in Germany following World War II, where it was called "Darmbrand" (meaning bowel necrosis). The toxin is normally inactivated by certain proteolytic enzymes and by normal cooking, but when these protections are impeded, and low protein is consumed, the disease emerges. Sporadic and extremely rare cases occur in diabetics. In New Guinea, where people eat a lot of sweet potatoes,