Domingo Liotta Domingo Liotta Domingo Santo Liotta (born November 29, 1924) is a pioneer of heart surgery, creator of multiple cardiac prostheses including the first total artificial heart used in a human being. Domingo Santo Liotta son of Italian immigrants, was born in the city of Diamante, Entre Rios, Argentina on November 29, 1924. He completed his elementary school at his hometown at "Independencia School", and his high school at the "Justo Jose de Urquiza School" in Concepcion del Uruguay, Entre Rios. In 1949, he graduated as a Medical Doctor at National University of Córdoba (Argentina). He received a doctorate in Medicine
Artificial cell cells have been proposed as a non-viral vector by which genetically modified non-autologous cells are encapsulated and implanted to deliver recombinant proteins "in vivo". This type of immuno-isolation has been proven efficient in mice through delivery of artificial cells containing mouse growth hormone which rescued a growth-retardation in mutant mice. A few strategies have advanced to human clinical trials for the treatment of pancreatic cancer, lateral sclerosis and pain control. The first clinical use of artificial cells was in hemoperfusion by the encapsulation of activated charcoal. Activated charcoal has the capability of adsorbing many large molecules and has for a