Free fatty acid receptor 2 Free fatty acid receptor 2 Free fatty acid receptor 2 (FFAR2) is a G-protein coupled receptor encoded by the FFAR2 gene. FFAR2 mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells. FFAR2 transcription is regulated by the XBP1 transcription factor which binds to the core promoter. Mouse studies utilizing Ffar2 gene deletions have implicated the receptor in the regulation of energy metabolism and immune responses. Short Chain Fatty Acids (SCFA's) generated in the processing of fiber by intestinal microbiota act as ligands for the receptor and can affect neutrophil chemotaxis. However, discrepancies
The Bones of What You Believe The Bones of What You Believe The Bones of What You Believe is the debut studio album by Scottish synth-pop band Chvrches, released on 20 September 2013 by Virgin Records and Goodbye Records. Recorded between 2011 and 2013 in Glasgow, the album was written, composed, and produced by the band as a collaborative effort. It was made available as both a 12-track standard edition and an 18-track special version, the latter including two extra songs, two remixes and two live videos. The album was debuted with a launch party broadcast live on music streaming platform Boiler Room. The album's title