Domingo Liotta Domingo Liotta Domingo Santo Liotta (born November 29, 1924) is a pioneer of heart surgery, creator of multiple cardiac prostheses including the first total artificial heart used in a human being. Domingo Santo Liotta son of Italian immigrants, was born in the city of Diamante, Entre Rios, Argentina on November 29, 1924. He completed his elementary school at his hometown at "Independencia School", and his high school at the "Justo Jose de Urquiza School" in Concepcion del Uruguay, Entre Rios. In 1949, he graduated as a Medical Doctor at National University of Córdoba (Argentina). He received a doctorate in Medicine
Human artificial chromosome benefits of HACs, namely their ability to stably contain extremely large genomic fragments. Researchers incorporated the 2.4Mb dystrophin gene, in which a mutation is a key causal element of Duchenne muscular dystrophy. The resulting HAC was mitotically stable, and correctly expressed dystrophin in chimeric mice. Previous attempts at correctly expressing dystrophin have failed. Due to its large size, it has never before been successfully integrated into a vector. In 2010, a refined human artificial chromosome called 21HAC was reported. 21HAC is based on a stripped copy of human chromosome 21, producing a chromosome 5Mb in length. Truncation of chromosome 21