Free fatty acid receptor 2 Free fatty acid receptor 2 Free fatty acid receptor 2 (FFAR2) is a G-protein coupled receptor encoded by the FFAR2 gene. FFAR2 mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells. FFAR2 transcription is regulated by the XBP1 transcription factor which binds to the core promoter. Mouse studies utilizing Ffar2 gene deletions have implicated the receptor in the regulation of energy metabolism and immune responses. Short Chain Fatty Acids (SCFA's) generated in the processing of fiber by intestinal microbiota act as ligands for the receptor and can affect neutrophil chemotaxis. However, discrepancies
The Bones of What You Believe fusion of emotive theatrics, hook-loaded songwriting, and some of the more forward-thinking sonics in electronic music right now", and found that "the hooks on "The Bones of What You Believe" are indelible regardless of instrumentation, and the sound is immaculate." At "Spin", Puja Patel opined that the album is "at its best on its revenge tunes", concluding, "In a mainstream landscape that's still reveling in the EDM-fueled fuck-yous of Icona Pop and Charli XCX's 'I Love It,' CHVRCHES' poppy electronic textures and bleakly lyrical brashness raises the bar." "Rolling Stone"s Jon Dolan expressed, "Even when Chvrches are just competently mopey,