Reticular connective tissue many free blood cells (largely lymphocytes) in lymph nodes, the spleen, and red bone marrow. There are more than 20 types of reticular fibers. In Reticular Connective Tissue type III collagen/reticular fiber (100-150 nm in diameter) is the major fiber component. It forms the architectural framework of liver, adipose tissue, bone marrow, spleen and basement membrane, to name a few. Notes Reticular connective tissue Reticular connective tissue is a type of connective tissue with a network of reticular fibers, made of type III collagen ("reticulum" = net or network). Reticular fibers are not unique to reticular connective tissue, but only
Follicular dendritic cells Noncognate B cells play a significant role as an antigen transporter to FDCs. They capture immune complexes in CR1/2-dependent way either directly from the blood or from macrophages, and putate to the lymphoid tissue, where they upload FDCs with opsonized antigen. FDCs, in turn, attract B cells with chemoattractant CXCL13. B cells lacking CXCR5, the receptor for CXCL13, still enter the white pulp, but are mislocalized and disorganized. To generate follicular structures, FDCs need to be stimulated by lymphotoxin (LT), a mediator produced by B cells. The stimulation of CXCR5 on B cells upregulates LT production, which leads to FDCs