Free fatty acid receptor 2 Free fatty acid receptor 2 Free fatty acid receptor 2 (FFAR2) is a G-protein coupled receptor encoded by the FFAR2 gene. FFAR2 mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells. FFAR2 transcription is regulated by the XBP1 transcription factor which binds to the core promoter. Mouse studies utilizing Ffar2 gene deletions have implicated the receptor in the regulation of energy metabolism and immune responses. Short Chain Fatty Acids (SCFA's) generated in the processing of fiber by intestinal microbiota act as ligands for the receptor and can affect neutrophil chemotaxis. However, discrepancies
Generative tissue and has a unique cellular and biochemical make-up that make it distinct from other tissues of the body. gTissue was discovered through research in the fields of Tissue Engineering and Regenerative Medicine and first created as a dense connective tissue between the brain and skull during the repair of canine dura mater. It has since been successfully created in humans for a wide range of clinical applications in soft tissue healing and repair. Essentially, the gTissue is created by implanting certain types of non-inflammatory ECM biomaterials that are adopted by the host, including repopulation with host cells and blood vessels,