Osmotic nephrosis Osmotic nephrosis Osmotic nephrosis refers to structural changes that occur at the cellular level in the human kidney. Cells, primarily of the straight proximal tubule, swell due to the formation of large vacuoles in the cytoplasm. These vacuoles occur in the presence of large amounts of certain solutes circulating in the tubules. However, despite the condition's name, the solutes do not cause change through osmotic forces but through pinocytosis. Once inside the cytoplasm, pinocytic vacuoles combine with each other and with lysosomes to form large vacuoles that appear transparent under microscopic examination. There may be no symptomatic presentation with this
The Hermetic Organ The Hermetic Organ The Hermetic Organ is an album by John Zorn, consisting of a single live improvisation on the Aeolian-Skinner pipe organ of St. Paul's Chapel at Columbia University, which was released on Tzadik Records in June 2012. The performance was held at 11 PM on the evening of December 9, 2011, which Zorn has noted was a full moon, as an encore to a "Composer Portrait" ensemble performance of his works held earlier that night at the Miller Theatre. It is the first release by Zorn to exclusively document his solo improvisations on the organ, his first instrument.