Atomic nucleus shells indicate that nuclear stability is much more complex than simple closure of shell orbitals with magic numbers of protons and neutrons. For larger nuclei, the shells occupied by nucleons begin to differ significantly from electron shells, but nevertheless, present nuclear theory does predict the magic numbers of filled nuclear shells for both protons and neutrons. The closure of the stable shells predicts unusually stable configurations, analogous to the noble group of nearly-inert gases in chemistry. An example is the stability of the closed shell of 50 protons, which allows tin to have 10 stable isotopes, more than any other
Hydrogen–deuterium exchange can be measured at atomic resolution quantitatively by neutron crystallography, and in real time if exchange is conducted during the diffraction experiment. High intensity neutron beams are generally generated by spallation at linac particle accelerators such as the Spallation Neutron Source. Neutrons diffract crystals similarly to X-rays and can be used for structural determination. Hydrogen atoms, with between one and zero electrons in a biological setting, diffract X-rays poorly and are effectively invisible under normal experimental conditions. Neutrons scatter from atomic nuclei, and are therefore capable of detecting hydrogen and deuterium atoms. Hydrogen atoms are routinely replaced with deuterium, which