Free fatty acid receptor 2 Free fatty acid receptor 2 Free fatty acid receptor 2 (FFAR2) is a G-protein coupled receptor encoded by the FFAR2 gene. FFAR2 mRNA is expressed in adipose tissue, pancreas, spleen, lymph nodes, bone marrow, and peripheral blood mononuclear cells. FFAR2 transcription is regulated by the XBP1 transcription factor which binds to the core promoter. Mouse studies utilizing Ffar2 gene deletions have implicated the receptor in the regulation of energy metabolism and immune responses. Short Chain Fatty Acids (SCFA's) generated in the processing of fiber by intestinal microbiota act as ligands for the receptor and can affect neutrophil chemotaxis. However, discrepancies
The Bones of What You Believe States. "The Bones of What You Believe" received mostly positive reviews from music critics. At Metacritic, which assigns a weighted mean rating out of 100 to reviews from mainstream critics, the album received an average score of 80, based on 39 reviews, indicating "generally favorable reviews". Kyle Ryan of "The A.V. Club" complimented Mayberry's songwriting and wrote that Chvrches "have crafted one of the year's best albums, which means that buzz won't be dying down any time soon." Joe Rivers of "Clash" lauded the album as "an exceptionally strong debut where every track is a potential single", noting that "[n]ot