Robert Jarvik animal in the lab for 10 days. Kolff assigned Jarvik to design a new heart that would overcome the problems of the Kwan-Gett heart, eventually culminating with the Jarvik-7 device. In 1982, the team carried out an artificial heart implant - the second ever, 13 years after Domingo Liotta and Denton Cooley's first in 1969. William DeVries first implanted the Jarvik-7 into retired dentist Barney Clark at the University of Utah on December 2, 1982. Clark required frequent visits to the hospital for the next 112 days, after which he died. During frequent press conferences to update the patient's condition,
Human artificial chromosome benefits of HACs, namely their ability to stably contain extremely large genomic fragments. Researchers incorporated the 2.4Mb dystrophin gene, in which a mutation is a key causal element of Duchenne muscular dystrophy. The resulting HAC was mitotically stable, and correctly expressed dystrophin in chimeric mice. Previous attempts at correctly expressing dystrophin have failed. Due to its large size, it has never before been successfully integrated into a vector. In 2010, a refined human artificial chromosome called 21HAC was reported. 21HAC is based on a stripped copy of human chromosome 21, producing a chromosome 5Mb in length. Truncation of chromosome 21