Mr. Big (Sex and the City) Mr. Big (Sex and the City) John James "Mr. Big" Preston is a recurring character in the HBO series "Sex and the City", portrayed by Chris Noth. He is the primary on-and-off love interest of the series' protagonist, Carrie Bradshaw, who usually simply refers to him as "Big". According to accounts in the press, the Mr. Big character was based on publishing executive Ron Galotti, former publisher of "GQ" and "Talk". Bushnell told "New York Magazine" in 2004, "He was one of those New York guys with a big personality—you just notice him as soon as he walks in the
Sex determination in Silene and mutations in the Y chromosome during reproduction, then different sex-linked genes are lost. The different combinations of possible sex-related genes that an individual "Silene" can have in one Y chromosome are what creates the rich variation of sexual phenotypes throughout this genus. The system for determining sex in "Silene latifolia" is close to that found in humans because in both cases the Y chromosome determines what reproductive mechanisms will be expressed in the offspring. They differ because there are multiple sex determining genes on the Y chromosome of "S. latifolia", while in humans the presence or absence of the