Blade (film) has become the vampire hunter Blade. He raids a Los Angeles rave club owned by the vampire Deacon Frost. Police take one of the vampires to the hospital, where he kills Dr. Curtis Webb and feeds on hematologist Karen Jenson and escapes. Blade takes Karen to a safe house where she is treated by his old friend Abraham Whistler (Kristofferson). Whistler explains that he and Blade have been waging a secret war against vampires using weapons based on their elemental weaknesses, such as sunlight and silver. As Karen is now "marked" by the bite of a vampire, both he and
Abraham Whistler then tortured again. Blade, Whistler, and Scud were summoned by the Shadow Council, ruled by overlord Eli Damaskinos, to eradicate the reaper threat. Reinhardt and Chupa (played by Matt Schulze), a friend of Priest who now wishes to kill Whistler to even the score with Blade, corner Whistler, and Chupa proceeds to savagely beat him. Reinhardt leaves the two. Whistler, to save himself, releases the reaper pheromones into the air. As Chupa is about to finish him off with a gun, reapers swarm the sewers and feed on Chupa, allowing Whistler to slip away. During his escape, Whistler is confronted