Digitalis digitalis. As a result of increased contractility, stroke volume is increased. Ultimately, digitalis increases cardiac output (Cardiac Output=Stroke Volume x Heart Rate). This is the mechanism that makes this drug a popular treatment for congestive heart failure, which is characterized by low cardiac output. Digitalis also has a vagal effect on the parasympathetic nervous system, and as such is used in re-entrant cardiac arrhythmias and to slow the ventricular rate during atrial fibrillation. The dependence on the vagal effect means digitalis is not effective when a patient has a high sympathetic nervous system drive, which is the case with acutely
Where Do We Go from Here? (1945 film) cuts were made in his proposed score for "Where Do We Go from Here", most of his work with Ira Gershwin remains, including a lengthy mock-opera bouffé aboard Columbus' ship during which the crew threatens to mutiny. Co-stars June Haver and Fred MacMurray met while working on this film, and were later married. "Where Do We Go from Here?" has never been released on home video. A recording taken directly from the soundtrack of the film was released on LP (Ariel KWH 10) and a set of rehearsal recordings performed by Kurt Weill and Ira Gershwin is currently available on