Digitalis lactone and a triple-repeating sugar called a glycoside. Digitalis works by inhibiting sodium-potassium ATPase. This results in an increased intracellular concentration of sodium ions and thus a decreased concentration gradient across the cell membrane. This increase in intracellular sodium causes the Na/Ca exchanger to reverse potential, i.e., transition from pumping sodium into the cell in exchange for pumping calcium out of the cell, to pumping sodium out of the cell in exchange for pumping calcium into the cell. This leads to an increase in cytoplasmic calcium concentration, which improves cardiac contractility. Under normal physiological conditions, the cytoplasmic calcium used in
Where Do We Go from Here (album) Award for Rock Album of the Year at the 36th GMA Dove Awards. Where Do We Go from Here (album) Where Do We Go from Here is the third album by Christian metal band Pillar. The song "Bring Me Down" was featured on the 2005 Major League Baseball video game, MLB 2006, as well as the offroad racing game MX vs. ATV Unleashed. The song "Frontline", along with "Bring Me Down", reached No. 1 on the Christian rock charts. The album debuted at No. 74 on the "Billboard" 200. "Where Do We Go from Here" garnered generally positive reception from