Blade (film) has become the vampire hunter Blade. He raids a Los Angeles rave club owned by the vampire Deacon Frost. Police take one of the vampires to the hospital, where he kills Dr. Curtis Webb and feeds on hematologist Karen Jenson and escapes. Blade takes Karen to a safe house where she is treated by his old friend Abraham Whistler (Kristofferson). Whistler explains that he and Blade have been waging a secret war against vampires using weapons based on their elemental weaknesses, such as sunlight and silver. As Karen is now "marked" by the bite of a vampire, both he and
Abraham Whistler himself, was given a serum developed by Whistler that would stop him from craving human plasma. When Blade hunted Morbius the Living Vampire, a young human student who was accidentally mutated into a vampire-like creature, Blade discovered the Neogenic Recombinator, which could transform humans into vampires. Whistler told him not to destroy it, as it could also be used to cure Blade of his vampirism. Morbius was eventually driven into hibernation. While Blade was hunting a vampire in Europe, Whistler was visited by the Black Cat, who was looking for help to cure Morbius. Whistler told her that the only