Wishin' and Hopin' (Grey's Anatomy) for their new clinic, Dr. Richard Webber (James Pickens, Jr.) dealing with the repercussions of his upcoming retirement, and Dr. George O'Malley (T.R. Knight) facing negative response from colleagues on his unexpected marriage to Dr. Callie Torres (Sara Ramirez). Although the episode was fictionally set in Seattle, filming occurred in Los Angeles, California. Burton reprised her role as Dr. Ellis Grey in a guest star capacity, in addition to Sarah Utterback, who portrayed Olivia Harper. The title of the episode refers to the song "Wishin' and Hopin'", by British pop musician Dusty Springfield. The episode received mixed to favorable reviews,
You Don't Have to Say You Love Me reaching No. 11 in the United States. "You Don't Have to Say You Love Me" was also a Top Ten hit in Ireland for Red Hurley (No. 5/1978), in Italy for Wall Street Crash (No. 6/1983), and - as "En koskaan" - in Finland for Kristina Hautala (No. 6/1966). "Io che non vivo (senza te)" — "I, who can't live (without you)" — was introduced at the 15th edition of the Sanremo Festival by Pino Donaggio — who had co-written the song with Vito Pallavicini — and his team partner Jody Miller: the song got to the final at Sanremo