Digitalis purpurea" extract containing cardiac glycosides for the treatment of heart conditions was first described in the English-speaking medical literature by William Withering, in 1785, which is considered the beginning of modern therapeutics. It is used to increase cardiac contractility (it is a positive inotrope) and as an antiarrhythmic agent to control the heart rate, particularly in the irregular (and often fast) atrial fibrillation. Digitalis is hence often prescribed for patients in atrial fibrillation, especially if they have been diagnosed with congestive heart failure. Digoxin was approved for heart failure in 1998 under current regulations by the Food and Drug Administration
Where Do We Go from Here? (1945 film) cuts were made in his proposed score for "Where Do We Go from Here", most of his work with Ira Gershwin remains, including a lengthy mock-opera bouffé aboard Columbus' ship during which the crew threatens to mutiny. Co-stars June Haver and Fred MacMurray met while working on this film, and were later married. "Where Do We Go from Here?" has never been released on home video. A recording taken directly from the soundtrack of the film was released on LP (Ariel KWH 10) and a set of rehearsal recordings performed by Kurt Weill and Ira Gershwin is currently available on