Blade (film) has become the vampire hunter Blade. He raids a Los Angeles rave club owned by the vampire Deacon Frost. Police take one of the vampires to the hospital, where he kills Dr. Curtis Webb and feeds on hematologist Karen Jenson and escapes. Blade takes Karen to a safe house where she is treated by his old friend Abraham Whistler (Kristofferson). Whistler explains that he and Blade have been waging a secret war against vampires using weapons based on their elemental weaknesses, such as sunlight and silver. As Karen is now "marked" by the bite of a vampire, both he and
Blade II is ambushed, dragged underwater, and killed. While attempting to escape Whistler is stopped by Nomak who reveals information about Damaskinos and gives him a royal seal ring. Using a special UV emitter bomb pack, Blade kills all of the Reapers with the exception of Nomak and rescues Reinhardt and Nyssa, but is betrayed by Damaskinos and his people, who stun Blade unconscious. After Damaskinos' betrayal, he reveals that he created The Reaper virus in order to create a new race of vampires based on Blade and that Nomak was simply a failed experiment. Whistler rebuts Damaskino’s lies by throwing the