X-Men: Reign of Apocalypse controlled by Apocalypse with backgrounds that stay true to the X-Men comics. X-mansion, Blackbird, Genosha and other familiar locations are present. The playable X-Men roster consists of: Wolverine, Cyclops, Storm, and Rogue. Each character has a different super power that give them a unique playstyle. Boss enemies include classic villains from the comics such as Blob and Magneto. X-Men from the 616 Marvel Universe, such as Colossus and Nightcrawler are also allies of Apocalypse in this alternate universe and must be defeated. "X-Men: Reign of Apocalypse" is a side-scrolling action beat 'em up with 12 distinct levels. Each level has
X-Treme X-Men missing, Gambit wants to ensure that Ororo’s ruby remains safe. However, Gambit is attacked by an other-dimensional warrior named Shaitan, capturing Gambit and stealing the ruby. Shaitan then uses the gems and Gambit’s mutant ability to empower them, thus opening the portal for his master, Khan (who, taken by Ororo’s powers and beauty, wants to make her his queen). Ororo’s X-Men oppose and defeat the invaders, but not before Ororo is seriously injured by Madripoor’s ruling crime lord Viper (before the battle) and by Khan's harem (during the battle). Sage activates all of the powers that Rogue has ever imprinted