Blade (film) has become the vampire hunter Blade. He raids a Los Angeles rave club owned by the vampire Deacon Frost. Police take one of the vampires to the hospital, where he kills Dr. Curtis Webb and feeds on hematologist Karen Jenson and escapes. Blade takes Karen to a safe house where she is treated by his old friend Abraham Whistler (Kristofferson). Whistler explains that he and Blade have been waging a secret war against vampires using weapons based on their elemental weaknesses, such as sunlight and silver. As Karen is now "marked" by the bite of a vampire, both he and
Blade II (video game) able to destroy the machine and then meets Whistler on the roof. Whistler gives him a canister of poison, which Blade puts into the ventilation system, killing every vampire in the building. Upon returning to their base, however, Blade and Whistler discover that their ally, Dr. Grant (Kate Magowan) has been kidnapped by the Byron vampire clan. Following her GPS signal leads to a subway station where Blade fights his way through the vampires into the sewers, where he is joined by Whistler, who plants a series of bombs. Blade detonates the explosives, and follows the sewers to Gaunt Moor