Digitalis lactone and a triple-repeating sugar called a glycoside. Digitalis works by inhibiting sodium-potassium ATPase. This results in an increased intracellular concentration of sodium ions and thus a decreased concentration gradient across the cell membrane. This increase in intracellular sodium causes the Na/Ca exchanger to reverse potential, i.e., transition from pumping sodium into the cell in exchange for pumping calcium out of the cell, to pumping sodium out of the cell in exchange for pumping calcium into the cell. This leads to an increase in cytoplasmic calcium concentration, which improves cardiac contractility. Under normal physiological conditions, the cytoplasmic calcium used in
How We Do (Party) How We Do (Party) "How We Do (Party)" is a song by British singer Rita Ora, from her debut studio album, "Ora". It was released as the lead single from the album in the United States, Canada, Australia and New Zealand on 20 March 2012. Upon its release, "How We Do (Party)" peaked inside the top-ten in Australia and New Zealand. It was released as the album's second single in Ireland on 10 August 2012 and in the United Kingdom on 12 August 2012, and reached number-one in both regions. "How We Do (Party)" is a pop and R&B song.