Digitalis lactone and a triple-repeating sugar called a glycoside. Digitalis works by inhibiting sodium-potassium ATPase. This results in an increased intracellular concentration of sodium ions and thus a decreased concentration gradient across the cell membrane. This increase in intracellular sodium causes the Na/Ca exchanger to reverse potential, i.e., transition from pumping sodium into the cell in exchange for pumping calcium out of the cell, to pumping sodium out of the cell in exchange for pumping calcium into the cell. This leads to an increase in cytoplasmic calcium concentration, which improves cardiac contractility. Under normal physiological conditions, the cytoplasmic calcium used in
Where Do We Go from Here: Chaos or Community? Where Do We Go from Here: Chaos or Community? Where Do We Go from Here: Chaos or Community? is a 1967 book by African-American minister, Nobel Peace Prize laureate, and social justice campaigner Martin Luther King, Jr. Advocating for human rights and a sense of hope, it was King's fourth and last book before his assassination. He spent a long period in isolation, living in a rented residence in Jamaica with no telephone, composing the book. It later lapsed out of print until Beacon Press published an expanded edition in 2010, which featured a new introduction passage by King's long-time