Digitalis lactone and a triple-repeating sugar called a glycoside. Digitalis works by inhibiting sodium-potassium ATPase. This results in an increased intracellular concentration of sodium ions and thus a decreased concentration gradient across the cell membrane. This increase in intracellular sodium causes the Na/Ca exchanger to reverse potential, i.e., transition from pumping sodium into the cell in exchange for pumping calcium out of the cell, to pumping sodium out of the cell in exchange for pumping calcium into the cell. This leads to an increase in cytoplasmic calcium concentration, which improves cardiac contractility. Under normal physiological conditions, the cytoplasmic calcium used in
(We Do It) Primo (We Do It) Primo "(We Do It) Primo" is a song by American recording artist Colette Carr. The song was written by Carr, and produced by Frankmusik. "(We Do It) Primo" was released on May 11, 2011 by Interscope as the first single from Carr's debut album "Skitszo". The song was written about just having fun and a good time. "(We Do It) Primo" is musically known as a "summer anthem" by many critics. It samples Keane’s song "Somewhere Only We Know". The song garnered mainly positive reviews from music critics. Many critics called it a "fun", "terrific" and "a