Digitalis purpurea pharmacological forms, extracts of this plant did not frequently cause intoxication because they induced nausea and vomiting within minutes of ingestion, preventing the patient from consuming more. The main toxins in "Digitalis" spp. are the two chemically similar cardiac glycosides: digitoxin and digoxin. Like other cardiac glycosides, these toxins exert their effects by inhibiting the ATPase activity of a complex of transmembrane proteins that form the sodium potassium ATPase pump, (Na/K-ATPase). Inhibition of the Na/K-ATPase in turn causes a rise not only in intracellular Na, but also in calcium, which in turn results in increased force of myocardial muscle contractions.
Where Do We Go from Here? (2015 film) Where Do We Go from Here? (2015 film) Where Do We Go from Here? is a Scottish comedy feature film by John McPhail. The film centres on James (Tyler Collins) a young man who takes on the role of a janitor of a care home when his Grandad is forced into social care. It is the first feature to be directed by John McPhail. When Jen starts her new Job as a nurse at the 'Easy Love Care Home, she is surprised to find James, a 25-year-old man living and working in the building. James and his three, elderly best