Digitalis lactone and a triple-repeating sugar called a glycoside. Digitalis works by inhibiting sodium-potassium ATPase. This results in an increased intracellular concentration of sodium ions and thus a decreased concentration gradient across the cell membrane. This increase in intracellular sodium causes the Na/Ca exchanger to reverse potential, i.e., transition from pumping sodium into the cell in exchange for pumping calcium out of the cell, to pumping sodium out of the cell in exchange for pumping calcium into the cell. This leads to an increase in cytoplasmic calcium concentration, which improves cardiac contractility. Under normal physiological conditions, the cytoplasmic calcium used in
Do You Feel Like We Do commercial with an improv riff from the song. Frampton plays the opening notes of the song for a 2012 TV commercial for the 2012 Buick Verano. The title of the song is "Do You Feel Like We Do," although the lyrics read, "Do you feel like I do?" Only after Bob Mayo's keyboard solo in the "Frampton Comes Alive!" version does Frampton sing, "Do you feel like we do?" He then sings "Do you feel like we do?" through the talk box in the midst of his extended guitar solo. This song was covered by Tesla, whose version can be