Blade (film) has become the vampire hunter Blade. He raids a Los Angeles rave club owned by the vampire Deacon Frost. Police take one of the vampires to the hospital, where he kills Dr. Curtis Webb and feeds on hematologist Karen Jenson and escapes. Blade takes Karen to a safe house where she is treated by his old friend Abraham Whistler (Kristofferson). Whistler explains that he and Blade have been waging a secret war against vampires using weapons based on their elemental weaknesses, such as sunlight and silver. As Karen is now "marked" by the bite of a vampire, both he and
Blade (film) his men attack the hideout, infect Whistler, and abduct Karen. When Blade returns, he helps Whistler commit suicide and arms himself with special syringes filled with EDTA. When Blade attempts to rescue Karen from Frost's penthouse, he is shocked to find his still alive mother, who reveals that she came back that very night and was brought in by Frost, who appears and reveals himself as the vampire who bit her. Blade is then subdued and taken to the Temple of Eternal Night, where Frost plans to perform the summoning ritual for La Magra, the vampire blood god. Karen is