X-Men: Reign of Apocalypse controlled by Apocalypse with backgrounds that stay true to the X-Men comics. X-mansion, Blackbird, Genosha and other familiar locations are present. The playable X-Men roster consists of: Wolverine, Cyclops, Storm, and Rogue. Each character has a different super power that give them a unique playstyle. Boss enemies include classic villains from the comics such as Blob and Magneto. X-Men from the 616 Marvel Universe, such as Colossus and Nightcrawler are also allies of Apocalypse in this alternate universe and must be defeated. "X-Men: Reign of Apocalypse" is a side-scrolling action beat 'em up with 12 distinct levels. Each level has
X-Men presented in the comics serve as allegory to modern issues in the real world, such as Lydia Nance suggesting mass mutant deportation. The X-Men exist in the Marvel Universe along with other characters featured in Marvel Comics series. They often meet characters from other series, and the global nature of the mutant concept means the scale of stories can be highly varied. The X-Men's enemies range from mutant thieves to galactic threats. Historically, the X-Men have been based in the Xavier Institute, in the town of Salem, located in Westchester County, New York, and are often portrayed as a family.