Wishin' and Hopin' (Grey's Anatomy) for their new clinic, Dr. Richard Webber (James Pickens, Jr.) dealing with the repercussions of his upcoming retirement, and Dr. George O'Malley (T.R. Knight) facing negative response from colleagues on his unexpected marriage to Dr. Callie Torres (Sara Ramirez). Although the episode was fictionally set in Seattle, filming occurred in Los Angeles, California. Burton reprised her role as Dr. Ellis Grey in a guest star capacity, in addition to Sarah Utterback, who portrayed Olivia Harper. The title of the episode refers to the song "Wishin' and Hopin'", by British pop musician Dusty Springfield. The episode received mixed to favorable reviews,
Wishin' and Hopin' she performed was "Wishin' and Hopin with the vocal accompaniment of Martha Reeves and the Vandellas. Springfield's recording was featured in the film, "A Home at the End of the World" (2004). "Wishin' and Hopin was also featured in "", the second episode of "". Springfield recorded foreign language versions of "Wishin' and Hopin in July 1964: in Italian as "Stupido Stupido" – which was a combination of lyrics in Italian and English, the latter being newly written rather than taken from the original song – and in German as "Warten Und Hoffen". "Wishin' and Hopin was also a hit