Digitalis lactone and a triple-repeating sugar called a glycoside. Digitalis works by inhibiting sodium-potassium ATPase. This results in an increased intracellular concentration of sodium ions and thus a decreased concentration gradient across the cell membrane. This increase in intracellular sodium causes the Na/Ca exchanger to reverse potential, i.e., transition from pumping sodium into the cell in exchange for pumping calcium out of the cell, to pumping sodium out of the cell in exchange for pumping calcium into the cell. This leads to an increase in cytoplasmic calcium concentration, which improves cardiac contractility. Under normal physiological conditions, the cytoplasmic calcium used in
Where Do We Go from Here? (2015 film) Film Awards. Where Do We Go from Here? (2015 film) Where Do We Go from Here? is a Scottish comedy feature film by John McPhail. The film centres on James (Tyler Collins) a young man who takes on the role of a janitor of a care home when his Grandad is forced into social care. It is the first feature to be directed by John McPhail. When Jen starts her new Job as a nurse at the 'Easy Love Care Home, she is surprised to find James, a 25-year-old man living and working in the building. James and his three,