Digitalis lactone and a triple-repeating sugar called a glycoside. Digitalis works by inhibiting sodium-potassium ATPase. This results in an increased intracellular concentration of sodium ions and thus a decreased concentration gradient across the cell membrane. This increase in intracellular sodium causes the Na/Ca exchanger to reverse potential, i.e., transition from pumping sodium into the cell in exchange for pumping calcium out of the cell, to pumping sodium out of the cell in exchange for pumping calcium into the cell. This leads to an increase in cytoplasmic calcium concentration, which improves cardiac contractility. Under normal physiological conditions, the cytoplasmic calcium used in
Where Do We Go from Here (Deborah Cox song) 28 on the US Hot R&B/Hip-Hop Songs. Where Do We Go from Here (Deborah Cox song) Where Do We Go from Here is a song by Canadian singer Deborah Cox. It was written by Larry "Rock" Campbell and Lascelles Stephens for her self-titled debut studio album (1995), while production was helmed by Vincent Herbert. Released as the album's third single along with a cover version of The S.O.S. Band's 1983 song "Just Be Good to Me", it became a moderate commercial success. "Where Do We Go from Here" entered the top forty of Canadian Singles Chart and peaked at number