Blade (film) has become the vampire hunter Blade. He raids a Los Angeles rave club owned by the vampire Deacon Frost. Police take one of the vampires to the hospital, where he kills Dr. Curtis Webb and feeds on hematologist Karen Jenson and escapes. Blade takes Karen to a safe house where she is treated by his old friend Abraham Whistler (Kristofferson). Whistler explains that he and Blade have been waging a secret war against vampires using weapons based on their elemental weaknesses, such as sunlight and silver. As Karen is now "marked" by the bite of a vampire, both he and
Abraham Whistler by Jared Nomak, the original Reaper, who lets Whistler live to reveal the truth about the Reaper strain to Blade. When Blade and Whistler are captured by Damaskinos thanks to Scud's betrayal, Whistler manages to escape after Reinhardt underestimates him, rescuing the injured Blade and taking him to a vat of blood so that Blade can be restored to full health to stop Damaskinos's forces and Nomak. In the , Blade is framed for the murder of several humans (who were in fact familiars being used as bait). Blade, now in the public eye and wanted by the FBI, is