Digitalis lactone and a triple-repeating sugar called a glycoside. Digitalis works by inhibiting sodium-potassium ATPase. This results in an increased intracellular concentration of sodium ions and thus a decreased concentration gradient across the cell membrane. This increase in intracellular sodium causes the Na/Ca exchanger to reverse potential, i.e., transition from pumping sodium into the cell in exchange for pumping calcium out of the cell, to pumping sodium out of the cell in exchange for pumping calcium into the cell. This leads to an increase in cytoplasmic calcium concentration, which improves cardiac contractility. Under normal physiological conditions, the cytoplasmic calcium used in
Where Do We Go from Here? (1945 film) Where Do We Go from Here? (1945 film) Where Do We Go from Here (1945) Technicolor is a romantic musical comedy-fantasy film produced by Twentieth Century-Fox, and starring Fred MacMurray, Joan Leslie, June Haver, Gene Sheldon, Anthony Quinn and Fortunio Bonanova. Joan Leslie's singing voice was dubbed by Sally Sweetland. The score was composed by Kurt Weill with lyrics by Ira Gershwin. Gregory Ratoff directed and Morrie Ryskind wrote the screenplay from a story by Sig Herzig and Ryskind. The film is notable as Weill's only musical written directly for the screen and for its anachronistic blend of history and