Blade (film) has become the vampire hunter Blade. He raids a Los Angeles rave club owned by the vampire Deacon Frost. Police take one of the vampires to the hospital, where he kills Dr. Curtis Webb and feeds on hematologist Karen Jenson and escapes. Blade takes Karen to a safe house where she is treated by his old friend Abraham Whistler (Kristofferson). Whistler explains that he and Blade have been waging a secret war against vampires using weapons based on their elemental weaknesses, such as sunlight and silver. As Karen is now "marked" by the bite of a vampire, both he and
Blade II House of Pain, frequented by vampires. They encounter the Reapers and discover their weapons are completely ineffective. Snowman spots and successfully attacks a Reaper, while Priest is ambushed and bitten by another Reaper. Nomak arrives and holds Nyssa hostage. Blade and Nomak fight, revealing Nomak is just as strong as Blade and has the ability to quickly heal from silver nitrate. The fight ends with Nomak gaining the upper hand on Blade but a burst of sunlight reflects off of Blade's sword, burning Nomak. Blade is forced to kill Priest after he becomes infected, Lighthammer is wounded and infected, Whistler