Blade (film) has become the vampire hunter Blade. He raids a Los Angeles rave club owned by the vampire Deacon Frost. Police take one of the vampires to the hospital, where he kills Dr. Curtis Webb and feeds on hematologist Karen Jenson and escapes. Blade takes Karen to a safe house where she is treated by his old friend Abraham Whistler (Kristofferson). Whistler explains that he and Blade have been waging a secret war against vampires using weapons based on their elemental weaknesses, such as sunlight and silver. As Karen is now "marked" by the bite of a vampire, both he and
Abraham Whistler partners. In the recent years though, Whistler was diagnosed with lung cancer from his smoking, and he realized that without him, Blade would be alone. Determined Blade wouldn't have to fight the war on his own, Whistler secretly began forming a team of vampire hunters. Around the same time, Abigail Whistler showed up, having tracked down her father, determined to know who had left her and her mother alone while occasionally supporting them. Whistler reluctantly told her everything, only to have an even more determined girl on his hands - one that wanted to follow in his footsteps. Seeing it