Wishin' and Hopin' (Grey's Anatomy) for their new clinic, Dr. Richard Webber (James Pickens, Jr.) dealing with the repercussions of his upcoming retirement, and Dr. George O'Malley (T.R. Knight) facing negative response from colleagues on his unexpected marriage to Dr. Callie Torres (Sara Ramirez). Although the episode was fictionally set in Seattle, filming occurred in Los Angeles, California. Burton reprised her role as Dr. Ellis Grey in a guest star capacity, in addition to Sarah Utterback, who portrayed Olivia Harper. The title of the episode refers to the song "Wishin' and Hopin'", by British pop musician Dusty Springfield. The episode received mixed to favorable reviews,
Wishin' and Hopin' (Grey's Anatomy) with the storyline involving Ellis being particularly praised by television critics. Upon its original airing, the episode was watched by 24.18 million viewers in the United States, ranked first in its time-slot and garnered an 8.5 Nielsen rating in the 18–49 demographic. "Wishin' and Hopin'" opens to a voice-over narration from Dr. Meredith Grey (Ellen Pompeo) about extraordinary events. The Denny Duquette Memorial Clinic has been opened, after a US$8 million funding from Dr. Izzie Stevens (Katherine Heigl). Four of the hospital's attending surgeons, Dr. Derek Shepherd (Patrick Dempsey), Dr. Preston Burke (Isaiah Washington), Dr. Addison Montgomery (Kate Walsh), and