Digitalis lactone and a triple-repeating sugar called a glycoside. Digitalis works by inhibiting sodium-potassium ATPase. This results in an increased intracellular concentration of sodium ions and thus a decreased concentration gradient across the cell membrane. This increase in intracellular sodium causes the Na/Ca exchanger to reverse potential, i.e., transition from pumping sodium into the cell in exchange for pumping calcium out of the cell, to pumping sodium out of the cell in exchange for pumping calcium into the cell. This leads to an increase in cytoplasmic calcium concentration, which improves cardiac contractility. Under normal physiological conditions, the cytoplasmic calcium used in
Where Do We Go from Here (Filter song) Where Do We Go from Here (Filter song) "Where Do We Go from Here" is a song by American industrial rock band Filter for their third studio album, The Amalgamut. The song was released as the album's first single in 2002. "Where Do We Go from Here" failed to match the success of their earlier hit single, 2000's "Take a Picture" on the "Billboard" Hot 100. However, it managed to come close to the top ten of the Hot Mainstream Rock Tracks and Hot Modern Rock Tracks charts at number 12 and number 11, respectively. A popular remix of this