Blade (film) has become the vampire hunter Blade. He raids a Los Angeles rave club owned by the vampire Deacon Frost. Police take one of the vampires to the hospital, where he kills Dr. Curtis Webb and feeds on hematologist Karen Jenson and escapes. Blade takes Karen to a safe house where she is treated by his old friend Abraham Whistler (Kristofferson). Whistler explains that he and Blade have been waging a secret war against vampires using weapons based on their elemental weaknesses, such as sunlight and silver. As Karen is now "marked" by the bite of a vampire, both he and
Blade (franchise) defeat Blade. They'll use their skills instead to help wipe out the Reaper threat. Blade's team and the Bloodpack are the only line of defense which can prevent the Reaper population from wiping out the vampire and human populations. The vampires succeed in framing Blade for the killing of a human (who was in fact a familiar being used as bait). Blade, now in the public's eye and wanted by the FBI, has to join forces with the Nightstalkers, a human clan of vampire hunters. Blade, Hannibal King, and Abigail Whistler go after Danica Talos, who has succeeded in locating