Blade (film) has become the vampire hunter Blade. He raids a Los Angeles rave club owned by the vampire Deacon Frost. Police take one of the vampires to the hospital, where he kills Dr. Curtis Webb and feeds on hematologist Karen Jenson and escapes. Blade takes Karen to a safe house where she is treated by his old friend Abraham Whistler (Kristofferson). Whistler explains that he and Blade have been waging a secret war against vampires using weapons based on their elemental weaknesses, such as sunlight and silver. As Karen is now "marked" by the bite of a vampire, both he and
Abraham Whistler several martial arts, having a part in creating many of Blade's weapons. When he discovered a thirteen-year-old Blade on the streets preying on the homeless, he took him under his wing. Realizing that he was half human and lacked a vampire's normal weaknesses with the exception of their thirst, he developed a serum to suppress Blade's vampiric lust for blood. Deacon Frost, an ambitious vampire whom Whistler and Blade had been tracking, located their base and attacked Whistler, causing him to be infected with vampirism. After informing Blade of Frost's plan to resurrect an ancient vampire god, Whistler then seemingly