IPod Touch (5th generation) iOS being iOS 6, iOS 7, iOS 8 and iOS 9. iOS 9 is said by Apple to feature performance improvements that may help the aging device function more smoothly. Other A5-based devices will also support iOS 9 including the iPad 2 (6 major iOS versions), the iPhone 4S (5 major iOS versions) and the iPad Mini (4 major iOS versions). iOS 9.3.5 is the last update that supports the iPod Touch 5th generation as it did not receive iOS 10 along with the iPhone 4S, iPad 2 and 3, and iPad Mini 1st generation due to hardware limitations. The
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling