Tap Tap Revenge the second-most downloaded free application of the year from their App Store, and the most downloaded free game. In April 2009, internet marketing research company comScore announced the results of a study which claimed 1 in 3 U.S. iPhone OS users had downloaded the game, and that it was the most popular application for the iPhone and iPod Touch. As part of the 2nd generation iPod touch advertising campaign, Apple featured "Tap Tap Revenge" in print and television ads with the headline "The funnest iPod ever.". The game spawned three direct sequels, "Tap Tap Revenge 2", "Tap Tap Revenge 3",
JUNQ and IPOD JUNQ and IPOD JUNQ and IPOD are types of cytosolic protein inclusion bodies in eukaryotes. Neurodegenerative diseases, such as Parkinson's, Alzheimer's, and Huntington's, are associated and correlated with protein aggregation and accumulation of misfolded proteins in inclusion bodies. For many years, protein aggregation was considered a random process by which misfolded proteins stick to each other to form inclusions (imagine a bundle of hairs haphazardly piling up in a corner of a room). Moreover, protein aggregates were thought to be toxic agents and the cause for neuronal dysfunction and death. However, recent studies, using advanced methods (i.e. fluorescence microscopy), show