IPhone OS 2 available to the iPhone and iPod Touch. Prior to the public release of iPhone OS 2.0, Apple held a keynote event to announce the iPhone OS Software Development Kit ("SDK") to developers. The most notable feature of iPhone OS 2 was the App Store. Before this feature was introduced, the only way to install custom applications on the device was via jailbreaking, which is strongly discouraged and unsupported by Apple. There were 500 applications available for download at the launch of the App Store, though this amount has grown dramatically since then. Now, the App Store has more than 2
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling