IPhone 5C the first three days, which set a record for first weekend smartphone sales, with the 5S selling three times more units than iPhone 5C. After the first day of release, 1% of all iPhone in the US were iPhone 5S, while 0.3% were iPhone 5C.<ref name="cnet iP5S/C sales 1"></ref> Commentators viewed iPhone 5C as a flop because of supply chain cuts signifying a decline in demand in October 2013. Apple CEO Tim Cook admitted that the company overstocked the iPhone 5C while having shortages of the iPhone 5S, as a result of failing to anticipate the sales ratio between both
JUNQ and IPOD the late onset of neurodegenerative diseases. In such diseases (e.g. Huntington's disease), a mutated protein misfolds and becomes toxic to the cellular environment by various ways such as denaturating cytosolic proteins. Incompetent of degrading those toxic species, the cell must isolate them to avoid their hazardous interaction with the cellular proteome. The IPOD was shown to be the sub-cellular site to which toxic amyloidogenic proteins are sequestered to, hereby serving as a protective quality control compartment. In addition, it was suggested by the Lindquist group, that the IPOD is the site where yeast prions undergo a maturation process. Thus, the