IPod Touch on March 6, 2008, at an Apple Town Hall meeting. The iOS SDK allows making applications for the iPhone and iPod Touch after paying a fee to join the development team. The developer can then set the price for the applications they develop and will receive 70% of money earned. Apple retains 30% of the sale price with no minimum fixed fee. Like all of Apple's iOS devices, the iPod Touch is a tightly controlled or closed platform. Modifying or replacing the operating system voids the device warranty, communication between apps is limited and controlled, and Apple is the only
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling