Portuguese discovery of the sea route to India of the "São Gabriel" and its sister ship, the "São Rafael" that were used by Vasco da Gama to sail past the Cape of Good Hope and continue to India. One of the sailors, Bartolomeu Dias passed the southernmost point of Africa known as the Cape of Good Hope in 1488. He declared it possible to travel to India by going around Africa. The Portuguese were then able to make an immense profit by using their own ships to retrieve the spices. This global expedition was launched on 8 July 1497. It concluded two years later with the entry of
Pacific Ocean for the elixir of immortality. From 1404 to 1433 Zheng He led expeditions into the Indian Ocean. The first contact of European navigators with the western edge of the Pacific Ocean was made by the Portuguese expeditions of António de Abreu and Francisco Serrão, via the Lesser Sunda Islands, to the Maluku Islands, in 1512, and with Jorge Álvares's expedition to southern China in 1513, both ordered by Afonso de Albuquerque from Malacca. The east side of the ocean was discovered by Spanish explorer Vasco Núñez de Balboa in 1513 after his expedition crossed the Isthmus of Panama and reached