Saffron slowly propagated throughout much of Eurasia and was later brought to parts of North Africa, North America, and Oceania. Saffron was detailed in a 7th-century BC Assyrian botanical reference compiled under Ashurbanipal. Documentation of saffron's use over the span of 3,500 years has been uncovered. Saffron-based pigments have indeed been found in 50,000-year-old depictions of prehistoric places in northwest Iran. The Sumerians later used wild-growing saffron in their remedies and magical potions. Saffron was an article of long-distance trade before the Minoan palace culture's 2nd millennium BC peak. Ancient Persians cultivated Persian saffron ("Crocus sativus" 'Hausknechtii') in Derbent, Isfahan, and
Saffron is present as 28% of the Daily Value, while other micronutrients have negligible content (table). One limited meta-analysis concluded that saffron supplementation improved symptoms in people with major depressive disorders. Another review of preliminary human research indicated that it may have effects on mild to moderate depression. The documented history of saffron cultivation spans more than three millennia. The wild precursor of domesticated saffron crocus is probably "Crocus cartwrightianus". If "C. sativus" is a mutant form of "C. cartwrightianus", then it may have emerged by human cultivators selectively breeding specimens for unusually long stigmas in late Bronze Age Crete. It