IPhone 4S due to the relatively aged hardware. In fact, some users often reported that performance on the 4S is very slow, similar to how iOS 7 ran on the iPhone 4, and suggesting that they should not upgrade due to battery draining issues and hanging up on calls. Meanwhile, Apple released iOS 8.1.1, which brought slight improvements to the phone and the iPad 2, but it still did not run as fast as newer models. On June 8, 2015, Apple announced at the WWDC that the iPhone 4S would support iOS 9. This makes it the first iPhone to support 5
JUNQ and IPOD and processing of different kinds of misfolded proteins (e.g. ubiquitinated vs. non-ubiquitinated proteins). Segregation of toxic protein aggregates into JUNQ and IPOD inclusion bodies is a means by which mammalian cells can be rejuvenated through asymmetric division. Thus, the discovery of JUNQ and IPOD provided a new striking perspective of how cells manage misfolded aggregated proteins and gave convincing proof that protein aggregation is a non-random, well regulated and controlled cellular process. Furthermore, the discovery of JUNQ and IPOD suggested that in addition to temporal quality control (i.e. time dependent administration of damaged proteins) cells exploit homeostasis spatially: If degradation