Indian Ocean trade Madagascar at this time leaving behind a lasting cultural and genetic legacy. Chinese fleets under Zheng He criscrossed the Indian Ocean during the early part of the 15th century. The missions were diplomatic rather than commercial, but many exchanges of gift and produces were made. The Portuguese under Vasco da Gama discovered a naval route to the Indian Ocean through the southern tip of Africa in 1497–98. Initially, the Portuguese were mainly active in Calicut, but the northern region of Gujarat was even more important for trade, and an essential intermediary in east-west trade. Venetian interests were directly threatened as
Pacific Ocean for the elixir of immortality. From 1404 to 1433 Zheng He led expeditions into the Indian Ocean. The first contact of European navigators with the western edge of the Pacific Ocean was made by the Portuguese expeditions of António de Abreu and Francisco Serrão, via the Lesser Sunda Islands, to the Maluku Islands, in 1512, and with Jorge Álvares's expedition to southern China in 1513, both ordered by Afonso de Albuquerque from Malacca. The east side of the ocean was discovered by Spanish explorer Vasco Núñez de Balboa in 1513 after his expedition crossed the Isthmus of Panama and reached