IPod Touch (5th generation) iOS being iOS 6, iOS 7, iOS 8 and iOS 9. iOS 9 is said by Apple to feature performance improvements that may help the aging device function more smoothly. Other A5-based devices will also support iOS 9 including the iPad 2 (6 major iOS versions), the iPhone 4S (5 major iOS versions) and the iPad Mini (4 major iOS versions). iOS 9.3.5 is the last update that supports the iPod Touch 5th generation as it did not receive iOS 10 along with the iPhone 4S, iPad 2 and 3, and iPad Mini 1st generation due to hardware limitations. The
JUNQ and IPOD IPOD may serve not only as a sequestration site, but also as a functional compartment. The IPOD is a non- membrane bound cellular site, which in yeast is located by the vacuole. FRAP and FLIP assays revealed that proteins in the IPOD are tightly packed, in-soluble and don't exchange with the cytosol. Amyloidogenic proteins, such as the Huntingtin protein, are the IPOD's substrates. Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD. Ubiquitination of an otherwise IPOD substrate, such as the RNQ1 fungal prion, will result in its sequestration in the JUNQ inclusion. Upon accumulation of misfolded proteins,