IPhone 5C the first three days, which set a record for first weekend smartphone sales, with the 5S selling three times more units than iPhone 5C. After the first day of release, 1% of all iPhone in the US were iPhone 5S, while 0.3% were iPhone 5C.<ref name="cnet iP5S/C sales 1"></ref> Commentators viewed iPhone 5C as a flop because of supply chain cuts signifying a decline in demand in October 2013. Apple CEO Tim Cook admitted that the company overstocked the iPhone 5C while having shortages of the iPhone 5S, as a result of failing to anticipate the sales ratio between both
JUNQ and IPOD and processing of different kinds of misfolded proteins (e.g. ubiquitinated vs. non-ubiquitinated proteins). Segregation of toxic protein aggregates into JUNQ and IPOD inclusion bodies is a means by which mammalian cells can be rejuvenated through asymmetric division. Thus, the discovery of JUNQ and IPOD provided a new striking perspective of how cells manage misfolded aggregated proteins and gave convincing proof that protein aggregation is a non-random, well regulated and controlled cellular process. Furthermore, the discovery of JUNQ and IPOD suggested that in addition to temporal quality control (i.e. time dependent administration of damaged proteins) cells exploit homeostasis spatially: If degradation