IPod charge the device) in an attempt to reduce cost and form factor. As of the second-generation iPod Touch and the fourth-generation iPod Nano, FireWire charging ability has been removed. The second-, third-, and fourth-generation iPod Shuffle uses a single 3.5 mm minijack phone connector which acts as both a headphone jack or a USB data and charging port for the dock/cable. The dock connector also allowed the iPod to connect to accessories, which often supplement the iPod's music, video, and photo playback. Apple sells a few accessories, such as the now-discontinued iPod Hi-Fi, but most are manufactured by third parties
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling