IPhone 4S due to the relatively aged hardware. In fact, some users often reported that performance on the 4S is very slow, similar to how iOS 7 ran on the iPhone 4, and suggesting that they should not upgrade due to battery draining issues and hanging up on calls. Meanwhile, Apple released iOS 8.1.1, which brought slight improvements to the phone and the iPad 2, but it still did not run as fast as newer models. On June 8, 2015, Apple announced at the WWDC that the iPhone 4S would support iOS 9. This makes it the first iPhone to support 5
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling