IPod Shuffle September 10, 2013, to coincide with the release of the iPhone 5S, the "Slate" color option was replaced with "Space Grey". On July 15, 2015, Apple released 6 new colors (blue, pink, silver, gold, space grey, and Product Red) for the iPod Shuffle. On July 27, 2017, Apple announced that it is discontinuing the iPod shuffle along with the iPod Nano. The iPod Shuffle was announced at the same time as the Mac Mini. Like the iPod Shuffle, the Mac Mini is a scaled-down product which has been introduced at a lower price. These two products together can be seen
JUNQ and IPOD and processing of different kinds of misfolded proteins (e.g. ubiquitinated vs. non-ubiquitinated proteins). Segregation of toxic protein aggregates into JUNQ and IPOD inclusion bodies is a means by which mammalian cells can be rejuvenated through asymmetric division. Thus, the discovery of JUNQ and IPOD provided a new striking perspective of how cells manage misfolded aggregated proteins and gave convincing proof that protein aggregation is a non-random, well regulated and controlled cellular process. Furthermore, the discovery of JUNQ and IPOD suggested that in addition to temporal quality control (i.e. time dependent administration of damaged proteins) cells exploit homeostasis spatially: If degradation