IPhone 4S due to the relatively aged hardware. In fact, some users often reported that performance on the 4S is very slow, similar to how iOS 7 ran on the iPhone 4, and suggesting that they should not upgrade due to battery draining issues and hanging up on calls. Meanwhile, Apple released iOS 8.1.1, which brought slight improvements to the phone and the iPad 2, but it still did not run as fast as newer models. On June 8, 2015, Apple announced at the WWDC that the iPhone 4S would support iOS 9. This makes it the first iPhone to support 5
JUNQ and IPOD the late onset of neurodegenerative diseases. In such diseases (e.g. Huntington's disease), a mutated protein misfolds and becomes toxic to the cellular environment by various ways such as denaturating cytosolic proteins. Incompetent of degrading those toxic species, the cell must isolate them to avoid their hazardous interaction with the cellular proteome. The IPOD was shown to be the sub-cellular site to which toxic amyloidogenic proteins are sequestered to, hereby serving as a protective quality control compartment. In addition, it was suggested by the Lindquist group, that the IPOD is the site where yeast prions undergo a maturation process. Thus, the