IPhone its older iPhones when issuing operating system upgrades. It has spurred allegations that the firm has been using this as a tactic to prompt users of older iPhones to buy newer models. Up to the iPhone 4, all iPhone models, as well as other iOS devices were manufactured exclusively by Foxconn, based in Taiwan. In 2011, after Tim Cook became CEO of the company, Apple changed its outsourcing strategy, for the first time increasing its supply partners. The iPhone 4s in 2012 was the first model which was manufactured simultaneously by two stand-alone companies: Foxconn as well as Pegatron, also
JUNQ and IPOD and processing of different kinds of misfolded proteins (e.g. ubiquitinated vs. non-ubiquitinated proteins). Segregation of toxic protein aggregates into JUNQ and IPOD inclusion bodies is a means by which mammalian cells can be rejuvenated through asymmetric division. Thus, the discovery of JUNQ and IPOD provided a new striking perspective of how cells manage misfolded aggregated proteins and gave convincing proof that protein aggregation is a non-random, well regulated and controlled cellular process. Furthermore, the discovery of JUNQ and IPOD suggested that in addition to temporal quality control (i.e. time dependent administration of damaged proteins) cells exploit homeostasis spatially: If degradation