IPhone towards a phone. Apple created the device during a secretive collaboration with Cingular Wireless (which became AT&T Mobility) at the time—at an estimated development cost of US$150 million over thirty months. According to Steve Jobs, the "i" word in "iMac" (and therefore "iPod", "iPhone" and "iPad") stands for internet, individual, instruct, inform, and inspire. Apple rejected the "design by committee" approach that had yielded the Motorola ROKR E1, a largely unsuccessful collaboration with Motorola. Among other deficiencies, the ROKR E1's firmware limited storage to only 100 iTunes songs to avoid competing with Apple's iPod nano. Cingular gave Apple the liberty
JUNQ and IPOD the late onset of neurodegenerative diseases. In such diseases (e.g. Huntington's disease), a mutated protein misfolds and becomes toxic to the cellular environment by various ways such as denaturating cytosolic proteins. Incompetent of degrading those toxic species, the cell must isolate them to avoid their hazardous interaction with the cellular proteome. The IPOD was shown to be the sub-cellular site to which toxic amyloidogenic proteins are sequestered to, hereby serving as a protective quality control compartment. In addition, it was suggested by the Lindquist group, that the IPOD is the site where yeast prions undergo a maturation process. Thus, the