Low Level Bombsight, Mark III use in October 1942. Coastal Command had priority on deliveries and only small numbers reached Bomber Command. The first examples arrived in May 1943 and were fit to Douglas Boston bombers of 2 Group. In 1944 the sight was trialled on the Avro Lancasters of No. 617 Squadron RAF, the Dambusters, who carried out a single low-level attack with them in late 1944. Most examples sent to Bomber Command equipped a small number of De Havilland Mosquito aircraft in No. 627 Squadron RAF (who normally operated as pathfinders) and No. 8 Group RAF (Pathfinder Force). The sight remained with Coastal
C-Raf Kss1 in yeast) are activated by MEKK-related kinases (e.g. Ste11 in yeast) instead of Raf enzymes. Raf kinases found in retroviruses (such as murine v-Raf) are secondarily derived from the corresponding vertebrate genes of their hosts. These Raf genes encode severely truncated proteins, that lack the entire N-terminal autoinhibitory domain, and the 14-3-3 binding motifs. Such severe truncations are known to induce an uncontrolled activity of Raf kinases: that is just exactly what a virus may need for efficient reproduction. As mentioned above, the regulation of c-Raf activity is complex. As a "gatekeeper" of the ERK1/2 pathway, it is kept