IPod as we cannibalize ourselves with the iPod Touch and the iPhone." Since 2009, the company's iPod sales have continually decreased every financial quarter and in 2013 a new model was not introduced onto the market. , Apple reported that total number of iPods sold worldwide was 350 million. iPods have won several awards ranging from engineering excellence, to most innovative audio product, to fourth best computer product of 2006. iPods often receive favorable reviews; scoring on looks, clean design, and ease of use. PC World says that iPod line has "altered the landscape for portable audio players". Several industries are
JUNQ and IPOD IPOD may serve not only as a sequestration site, but also as a functional compartment. The IPOD is a non- membrane bound cellular site, which in yeast is located by the vacuole. FRAP and FLIP assays revealed that proteins in the IPOD are tightly packed, in-soluble and don't exchange with the cytosol. Amyloidogenic proteins, such as the Huntingtin protein, are the IPOD's substrates. Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD. Ubiquitination of an otherwise IPOD substrate, such as the RNQ1 fungal prion, will result in its sequestration in the JUNQ inclusion. Upon accumulation of misfolded proteins,