IPhone its older iPhones when issuing operating system upgrades. It has spurred allegations that the firm has been using this as a tactic to prompt users of older iPhones to buy newer models. Up to the iPhone 4, all iPhone models, as well as other iOS devices were manufactured exclusively by Foxconn, based in Taiwan. In 2011, after Tim Cook became CEO of the company, Apple changed its outsourcing strategy, for the first time increasing its supply partners. The iPhone 4s in 2012 was the first model which was manufactured simultaneously by two stand-alone companies: Foxconn as well as Pegatron, also
JUNQ and IPOD the disaggregase chaperone, AAA protein HSP104, localizes to the IPOD. It is yet to be determined if HSP104 functions in the IPOD or is simply sequestered there being hooked to a substrate. The pre-autophagosomal structure (PAS) is localized by the IPOD. However, it wasn't shown that IPOD substrates are delivered to the vacuole, and so the link between the IPOD and autophagy is yet to be determined. JUNQ and IPOD JUNQ and IPOD are types of cytosolic protein inclusion bodies in eukaryotes. Neurodegenerative diseases, such as Parkinson's, Alzheimer's, and Huntington's, are associated and correlated with protein aggregation and accumulation of