IPhone the success of iPod campaigns, allowed the phone to become a mass-market product with many buyers on launch day. Some market research has found that, unusually for a technology product, iPhone users are disproportionately female. "Ars Technica" noted in 2012 that Apple had avoided 'patronizing' marketing to female customers, a practice used (often to sell low-quality, high-priced products) by many of its competitors. When then-CEO of Research in Motion Mike Lazaridis pried open an iPhone, his impression was of a Mac stuffed into a cellphone, as it used much more memory and processing power than the smartphones on the market
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling