IPhone OS 2 available to the iPhone and iPod Touch. Prior to the public release of iPhone OS 2.0, Apple held a keynote event to announce the iPhone OS Software Development Kit ("SDK") to developers. The most notable feature of iPhone OS 2 was the App Store. Before this feature was introduced, the only way to install custom applications on the device was via jailbreaking, which is strongly discouraged and unsupported by Apple. There were 500 applications available for download at the launch of the App Store, though this amount has grown dramatically since then. Now, the App Store has more than 2
JUNQ and IPOD IPOD may serve not only as a sequestration site, but also as a functional compartment. The IPOD is a non- membrane bound cellular site, which in yeast is located by the vacuole. FRAP and FLIP assays revealed that proteins in the IPOD are tightly packed, in-soluble and don't exchange with the cytosol. Amyloidogenic proteins, such as the Huntingtin protein, are the IPOD's substrates. Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD. Ubiquitination of an otherwise IPOD substrate, such as the RNQ1 fungal prion, will result in its sequestration in the JUNQ inclusion. Upon accumulation of misfolded proteins,