Craniopagus twins conjoined twins develop inutero remains unclear. Embryologists have traditionally attributed identical twinning as "splitting or fission" of either the inner cell mass of pleuripotential cells or early embryonic disc at 13–14 days of gestation just before the primitive streak. Some theorists suggested that conjoined twins develop as a result of the failed fusion of a single fertilized ovum. However a new hypothesis suggests that cranial fusion occurs between two separate embryos before the end of the 4th week of gestation. This can happen because the cranial neuropore is still open, which is responsible for the ultimate fusion and formation of
There are known knowns management and strategic planning circles. Known unknowns refers to "risks you are aware of, such as cancelled flights..." Unknown unknowns are risks that come from situations that are so unexpected that they would not be considered. "For example, prior to the invention of the personal computer, manufacturers of typewriters probably didn't foresee the risks to their business". Contemporary usage is largely consistent with the earliest known usages. For example, the term was used in evidence given to the British Columbia Royal Commission of Inquiry into Uranium Mining in 1979: The term also appeared in a 1982 "New Yorker" article on