IPod Nano game was dropped and replaced with a Maze game which makes use of the iPod's accelerometer similarly to such games on the iPhone and iPod Touch. The fourth generation dropped support for charging via FireWire. "This change means that any dock accessories that use the dock connector's FireWire pins to send power—many older speakers and car chargers, for example—will not charge the fourth-generation iPod Nano." At Apple's September 9, 2009 event, a fifth generation iPod Nano was unveiled with reduced prices on the larger model (at the time of release, the 8GB was priced at $149 and the 16GB at
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling