IPhone officially announced and released on March 6, 2008, at the Apple Town Hall facility. It is a free download, with an Apple registration, that allows developers to develop native applications for the iPhone and iPod Touch, then test them in an "iPhone simulator". However, loading an application onto a real device is only possible after paying an Apple Developer Connection membership fee. Developers are free to set any price for their applications to be distributed through the App Store, of which they will receive a 70% share. Developers can also opt to release the application for free and will not
JUNQ and IPOD the disaggregase chaperone, AAA protein HSP104, localizes to the IPOD. It is yet to be determined if HSP104 functions in the IPOD or is simply sequestered there being hooked to a substrate. The pre-autophagosomal structure (PAS) is localized by the IPOD. However, it wasn't shown that IPOD substrates are delivered to the vacuole, and so the link between the IPOD and autophagy is yet to be determined. JUNQ and IPOD JUNQ and IPOD are types of cytosolic protein inclusion bodies in eukaryotes. Neurodegenerative diseases, such as Parkinson's, Alzheimer's, and Huntington's, are associated and correlated with protein aggregation and accumulation of