Tattershall Thorpe 17th century, with 19th- and 20th-century alterations. It is constructed of "mud and stud" and partly underbuilt with painted brick. It is a Grade II listed building, and houses RAF memorabilia from RAF Woodhall Spa, an active RAF Station during the Second World War. The Bluebell Inn has signatures on its ceiling from some of the members of 97, 619, 617 (Dambusters) and 627 Squadrons who frequented the pub. RAF personnel from the Battle of Britain Memorial Flight and Squadrons from RAF Coningsby sign to this day to continue the tradition. Wing Commander Guy Penrose Gibson VC, DSO, DFC and
C-Raf Kss1 in yeast) are activated by MEKK-related kinases (e.g. Ste11 in yeast) instead of Raf enzymes. Raf kinases found in retroviruses (such as murine v-Raf) are secondarily derived from the corresponding vertebrate genes of their hosts. These Raf genes encode severely truncated proteins, that lack the entire N-terminal autoinhibitory domain, and the 14-3-3 binding motifs. Such severe truncations are known to induce an uncontrolled activity of Raf kinases: that is just exactly what a virus may need for efficient reproduction. As mentioned above, the regulation of c-Raf activity is complex. As a "gatekeeper" of the ERK1/2 pathway, it is kept