IPhone OS 2 Apple II and Mac as one of the great revolutions in modern technology. It takes it beyond simple Phone + iPod, or even smartphone, and makes it the leading contender for the next great shift in computing." However, they criticized it for having stability issues and overall sluggishness. "Macworld" said, "The iPhone 2.0 software is full of the kind of refinements that you’d expect from a second-generation Apple product. The iPhone OS still isn’t perfect, and we wish Apple has addressed some lingering shortcomings, but it’s a welcome step-up for what was already arguably the best mobile platform on the
JUNQ and IPOD IPOD may serve not only as a sequestration site, but also as a functional compartment. The IPOD is a non- membrane bound cellular site, which in yeast is located by the vacuole. FRAP and FLIP assays revealed that proteins in the IPOD are tightly packed, in-soluble and don't exchange with the cytosol. Amyloidogenic proteins, such as the Huntingtin protein, are the IPOD's substrates. Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD. Ubiquitination of an otherwise IPOD substrate, such as the RNQ1 fungal prion, will result in its sequestration in the JUNQ inclusion. Upon accumulation of misfolded proteins,