IPod Nano had the same price point as the 5th generation device. A firmware update (version 1.1) for the Nano was released on February 28, 2011. The update added the ability to change songs or pause with a double click of the sleep/wake button. It also added the ability to turn the device off by holding the sleep/wake button. The user interface was also enhanced. On October 4, 2011, the iPod Nano 1.2 update was unveiled at the Apple "Let's Talk iPhone" event at the Town Hall, 4 Infinite Loop. This update added the option to increase or decrease the size of
JUNQ and IPOD IPOD may serve not only as a sequestration site, but also as a functional compartment. The IPOD is a non- membrane bound cellular site, which in yeast is located by the vacuole. FRAP and FLIP assays revealed that proteins in the IPOD are tightly packed, in-soluble and don't exchange with the cytosol. Amyloidogenic proteins, such as the Huntingtin protein, are the IPOD's substrates. Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD. Ubiquitination of an otherwise IPOD substrate, such as the RNQ1 fungal prion, will result in its sequestration in the JUNQ inclusion. Upon accumulation of misfolded proteins,