IPhone of the iPhone have also garnered praise. The iPhone is one of the most widely used smartphones in the world, and its success has been credited with helping Apple become one of the world's most valuable publicly traded companies. Development of what was to become the iPhone began in 2004, when Apple started to gather a team of 1,000 employees (including Jonathan Ive, the designer behind the iMac and iPod) to work on the highly confidential "Project Purple." Apple CEO Steve Jobs steered the original focus away from a tablet (which Apple eventually revisited in the form of the iPad)
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling