IPhone towards a phone. Apple created the device during a secretive collaboration with Cingular Wireless (which became AT&T Mobility) at the time—at an estimated development cost of US$150 million over thirty months. According to Steve Jobs, the "i" word in "iMac" (and therefore "iPod", "iPhone" and "iPad") stands for internet, individual, instruct, inform, and inspire. Apple rejected the "design by committee" approach that had yielded the Motorola ROKR E1, a largely unsuccessful collaboration with Motorola. Among other deficiencies, the ROKR E1's firmware limited storage to only 100 iTunes songs to avoid competing with Apple's iPod nano. Cingular gave Apple the liberty
JUNQ and IPOD IPOD may serve not only as a sequestration site, but also as a functional compartment. The IPOD is a non- membrane bound cellular site, which in yeast is located by the vacuole. FRAP and FLIP assays revealed that proteins in the IPOD are tightly packed, in-soluble and don't exchange with the cytosol. Amyloidogenic proteins, such as the Huntingtin protein, are the IPOD's substrates. Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD. Ubiquitination of an otherwise IPOD substrate, such as the RNQ1 fungal prion, will result in its sequestration in the JUNQ inclusion. Upon accumulation of misfolded proteins,