IPod the iPod Nano and Shuffle from its stores, marking the end of Apple producing standalone music players. Currently, the iPod Touch is the only iPod produced by Apple. The third-generation iPod had a weak bass response, as shown in audio tests. The combination of the undersized DC-blocking capacitors and the typical low impedance of most consumer headphones form a high-pass filter, which attenuates the low-frequency bass output. Similar capacitors were used in the fourth-generation iPods. The problem is reduced when using high-impedance headphones and is completely masked when driving high-impedance (line level) loads, such as an external headphone amplifier. The
JUNQ and IPOD and processing of different kinds of misfolded proteins (e.g. ubiquitinated vs. non-ubiquitinated proteins). Segregation of toxic protein aggregates into JUNQ and IPOD inclusion bodies is a means by which mammalian cells can be rejuvenated through asymmetric division. Thus, the discovery of JUNQ and IPOD provided a new striking perspective of how cells manage misfolded aggregated proteins and gave convincing proof that protein aggregation is a non-random, well regulated and controlled cellular process. Furthermore, the discovery of JUNQ and IPOD suggested that in addition to temporal quality control (i.e. time dependent administration of damaged proteins) cells exploit homeostasis spatially: If degradation