IPhone pay any costs to release or distribute the application beyond the membership fee. The App Store was launched with the release of iOS 2.0, on July 11, 2008. The update was free for iPhone users; owners of older iPod Touches were required to pay US$10 for it. Once a developer has submitted an application to the App Store, Apple holds firm control over its distribution. Apple can halt the distribution of applications it deems inappropriate, for example, I Am Rich, a US$1000 program that simply demonstrated the wealth of its user. Apple has been criticized for banning third-party applications that
JUNQ and IPOD IPOD may serve not only as a sequestration site, but also as a functional compartment. The IPOD is a non- membrane bound cellular site, which in yeast is located by the vacuole. FRAP and FLIP assays revealed that proteins in the IPOD are tightly packed, in-soluble and don't exchange with the cytosol. Amyloidogenic proteins, such as the Huntingtin protein, are the IPOD's substrates. Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD. Ubiquitination of an otherwise IPOD substrate, such as the RNQ1 fungal prion, will result in its sequestration in the JUNQ inclusion. Upon accumulation of misfolded proteins,