IPod Shuffle on second-generation iPod Shuffles. On October 26, 2006, Apple released an iPod Shuffle Reset Utility that corrected this problem for some owners of first-generation iPod Shuffles. Then, in March 2007, an updated iPod Reset Utility was released which can also address similar problems with second-generation iPod Shuffles. Unlike most other portable audio players, the third-generation iPod Shuffle's controls are situated on the packaged headphones. The user is unable to control the device unless they use either Apple headphones designed for it, or third-party headphones or adapters that must be licensed by Apple. The third generation iPod Shuffle's headphones contain a
JUNQ and IPOD and processing of different kinds of misfolded proteins (e.g. ubiquitinated vs. non-ubiquitinated proteins). Segregation of toxic protein aggregates into JUNQ and IPOD inclusion bodies is a means by which mammalian cells can be rejuvenated through asymmetric division. Thus, the discovery of JUNQ and IPOD provided a new striking perspective of how cells manage misfolded aggregated proteins and gave convincing proof that protein aggregation is a non-random, well regulated and controlled cellular process. Furthermore, the discovery of JUNQ and IPOD suggested that in addition to temporal quality control (i.e. time dependent administration of damaged proteins) cells exploit homeostasis spatially: If degradation