IPod Shuffle on second-generation iPod Shuffles. On October 26, 2006, Apple released an iPod Shuffle Reset Utility that corrected this problem for some owners of first-generation iPod Shuffles. Then, in March 2007, an updated iPod Reset Utility was released which can also address similar problems with second-generation iPod Shuffles. Unlike most other portable audio players, the third-generation iPod Shuffle's controls are situated on the packaged headphones. The user is unable to control the device unless they use either Apple headphones designed for it, or third-party headphones or adapters that must be licensed by Apple. The third generation iPod Shuffle's headphones contain a
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling