IPhone its older iPhones when issuing operating system upgrades. It has spurred allegations that the firm has been using this as a tactic to prompt users of older iPhones to buy newer models. Up to the iPhone 4, all iPhone models, as well as other iOS devices were manufactured exclusively by Foxconn, based in Taiwan. In 2011, after Tim Cook became CEO of the company, Apple changed its outsourcing strategy, for the first time increasing its supply partners. The iPhone 4s in 2012 was the first model which was manufactured simultaneously by two stand-alone companies: Foxconn as well as Pegatron, also
JUNQ and IPOD IPOD may serve not only as a sequestration site, but also as a functional compartment. The IPOD is a non- membrane bound cellular site, which in yeast is located by the vacuole. FRAP and FLIP assays revealed that proteins in the IPOD are tightly packed, in-soluble and don't exchange with the cytosol. Amyloidogenic proteins, such as the Huntingtin protein, are the IPOD's substrates. Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD. Ubiquitination of an otherwise IPOD substrate, such as the RNQ1 fungal prion, will result in its sequestration in the JUNQ inclusion. Upon accumulation of misfolded proteins,