Conjoined gene Conjoined gene A conjoined gene (CG) is defined as a gene, which gives rise to transcripts by combining at least part of one exon from each of two or more distinct known (parent) genes which lie on the same chromosome, are in the same orientation, and often (95%) translate independently into different proteins. In some cases, the transcripts formed by CGs are translated to form chimeric or completely novel proteins. Figure 1: Cartoonic representation of the formation of conjoined gene A-B from parent genes A and B. Several alternative names are used to address conjoined genes, including combined gene and
There are known knowns management and strategic planning circles. Known unknowns refers to "risks you are aware of, such as cancelled flights..." Unknown unknowns are risks that come from situations that are so unexpected that they would not be considered. "For example, prior to the invention of the personal computer, manufacturers of typewriters probably didn't foresee the risks to their business". Contemporary usage is largely consistent with the earliest known usages. For example, the term was used in evidence given to the British Columbia Royal Commission of Inquiry into Uranium Mining in 1979: The term also appeared in a 1982 "New Yorker" article on