IPhone 4S due to the relatively aged hardware. In fact, some users often reported that performance on the 4S is very slow, similar to how iOS 7 ran on the iPhone 4, and suggesting that they should not upgrade due to battery draining issues and hanging up on calls. Meanwhile, Apple released iOS 8.1.1, which brought slight improvements to the phone and the iPad 2, but it still did not run as fast as newer models. On June 8, 2015, Apple announced at the WWDC that the iPhone 4S would support iOS 9. This makes it the first iPhone to support 5
JUNQ and IPOD IPOD may serve not only as a sequestration site, but also as a functional compartment. The IPOD is a non- membrane bound cellular site, which in yeast is located by the vacuole. FRAP and FLIP assays revealed that proteins in the IPOD are tightly packed, in-soluble and don't exchange with the cytosol. Amyloidogenic proteins, such as the Huntingtin protein, are the IPOD's substrates. Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD. Ubiquitination of an otherwise IPOD substrate, such as the RNQ1 fungal prion, will result in its sequestration in the JUNQ inclusion. Upon accumulation of misfolded proteins,