Tap Tap Revenge the second-most downloaded free application of the year from their App Store, and the most downloaded free game. In April 2009, internet marketing research company comScore announced the results of a study which claimed 1 in 3 U.S. iPhone OS users had downloaded the game, and that it was the most popular application for the iPhone and iPod Touch. As part of the 2nd generation iPod touch advertising campaign, Apple featured "Tap Tap Revenge" in print and television ads with the headline "The funnest iPod ever.". The game spawned three direct sequels, "Tap Tap Revenge 2", "Tap Tap Revenge 3",
JUNQ and IPOD the disaggregase chaperone, AAA protein HSP104, localizes to the IPOD. It is yet to be determined if HSP104 functions in the IPOD or is simply sequestered there being hooked to a substrate. The pre-autophagosomal structure (PAS) is localized by the IPOD. However, it wasn't shown that IPOD substrates are delivered to the vacuole, and so the link between the IPOD and autophagy is yet to be determined. JUNQ and IPOD JUNQ and IPOD are types of cytosolic protein inclusion bodies in eukaryotes. Neurodegenerative diseases, such as Parkinson's, Alzheimer's, and Huntington's, are associated and correlated with protein aggregation and accumulation of