Indian Ocean trade Madagascar at this time leaving behind a lasting cultural and genetic legacy. Chinese fleets under Zheng He criscrossed the Indian Ocean during the early part of the 15th century. The missions were diplomatic rather than commercial, but many exchanges of gift and produces were made. The Portuguese under Vasco da Gama discovered a naval route to the Indian Ocean through the southern tip of Africa in 1497–98. Initially, the Portuguese were mainly active in Calicut, but the northern region of Gujarat was even more important for trade, and an essential intermediary in east-west trade. Venetian interests were directly threatened as
European route E01 in Portugal largest city in Portugal Porto. From this coastal city on the Atlantic Ocean, the E01 goes southwest, using the A1 motorway to the Centro Region passing by the major cities of Coimbra and Leiria to the Portuguese capital Lisbon. The motorway passes through the city center, from where it takes the A2 motorway crossing the sparsely populated Alentejo Region all the way until the south coast in the Algarve region at the merge with the A22 motorway at Albufeira. The road goes then east passing by Faro to the Spanish border at the Guadiana river in the Portuguese village of