IPod Shuffle on second-generation iPod Shuffles. On October 26, 2006, Apple released an iPod Shuffle Reset Utility that corrected this problem for some owners of first-generation iPod Shuffles. Then, in March 2007, an updated iPod Reset Utility was released which can also address similar problems with second-generation iPod Shuffles. Unlike most other portable audio players, the third-generation iPod Shuffle's controls are situated on the packaged headphones. The user is unable to control the device unless they use either Apple headphones designed for it, or third-party headphones or adapters that must be licensed by Apple. The third generation iPod Shuffle's headphones contain a
JUNQ and IPOD the late onset of neurodegenerative diseases. In such diseases (e.g. Huntington's disease), a mutated protein misfolds and becomes toxic to the cellular environment by various ways such as denaturating cytosolic proteins. Incompetent of degrading those toxic species, the cell must isolate them to avoid their hazardous interaction with the cellular proteome. The IPOD was shown to be the sub-cellular site to which toxic amyloidogenic proteins are sequestered to, hereby serving as a protective quality control compartment. In addition, it was suggested by the Lindquist group, that the IPOD is the site where yeast prions undergo a maturation process. Thus, the