Royal Air Force and replacement by the F-35, the RAF Lossiemouth-based 15 (Reserve) Squadron (the Tornado Operational Conversion Unit) was disbanded in March 2017. Lightning: On 23 November 2015 it was announced that a total of 138 F-35Bs will be ordered. 617 (The Dambusters) Squadron officially reformed on 18 April 2018 as an RAF Lightning Squadron. The first four aircraft arrived at RAF Marham on 7 June 2018. The Sentry AEW1, based at RAF Waddington, provides airborne early warning to detect incoming enemy aircraft and to co-ordinate the aerial battlefield. The Sentinel R1 (formally known as ASTOR – Airborne STand-Off Radar) provides a
C-Raf Kss1 in yeast) are activated by MEKK-related kinases (e.g. Ste11 in yeast) instead of Raf enzymes. Raf kinases found in retroviruses (such as murine v-Raf) are secondarily derived from the corresponding vertebrate genes of their hosts. These Raf genes encode severely truncated proteins, that lack the entire N-terminal autoinhibitory domain, and the 14-3-3 binding motifs. Such severe truncations are known to induce an uncontrolled activity of Raf kinases: that is just exactly what a virus may need for efficient reproduction. As mentioned above, the regulation of c-Raf activity is complex. As a "gatekeeper" of the ERK1/2 pathway, it is kept