IPhone its older iPhones when issuing operating system upgrades. It has spurred allegations that the firm has been using this as a tactic to prompt users of older iPhones to buy newer models. Up to the iPhone 4, all iPhone models, as well as other iOS devices were manufactured exclusively by Foxconn, based in Taiwan. In 2011, after Tim Cook became CEO of the company, Apple changed its outsourcing strategy, for the first time increasing its supply partners. The iPhone 4s in 2012 was the first model which was manufactured simultaneously by two stand-alone companies: Foxconn as well as Pegatron, also
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling