IPhone 5 Buena Center for the Arts in San Francisco on September 12, 2012. A shadow of the numeral 5 was featured in the invitations sent to the media, suggesting that the next iPhone would be unveiled at the event. At the unveiling, Apple announced the iPhone 5 and also introduced new iPod Nano and iPod Touch models. They also stated that pre-orders would be accepted starting September 14, 2012. Over two million pre-orders were received within 24 hours. Initial demand for the new phone exceeded the record set by its predecessor, the iPhone 4s, by selling over 5 million units in
JUNQ and IPOD IPOD may serve not only as a sequestration site, but also as a functional compartment. The IPOD is a non- membrane bound cellular site, which in yeast is located by the vacuole. FRAP and FLIP assays revealed that proteins in the IPOD are tightly packed, in-soluble and don't exchange with the cytosol. Amyloidogenic proteins, such as the Huntingtin protein, are the IPOD's substrates. Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD. Ubiquitination of an otherwise IPOD substrate, such as the RNQ1 fungal prion, will result in its sequestration in the JUNQ inclusion. Upon accumulation of misfolded proteins,