IPhone of the iPhone have also garnered praise. The iPhone is one of the most widely used smartphones in the world, and its success has been credited with helping Apple become one of the world's most valuable publicly traded companies. Development of what was to become the iPhone began in 2004, when Apple started to gather a team of 1,000 employees (including Jonathan Ive, the designer behind the iMac and iPod) to work on the highly confidential "Project Purple." Apple CEO Steve Jobs steered the original focus away from a tablet (which Apple eventually revisited in the form of the iPad)
JUNQ and IPOD IPOD may serve not only as a sequestration site, but also as a functional compartment. The IPOD is a non- membrane bound cellular site, which in yeast is located by the vacuole. FRAP and FLIP assays revealed that proteins in the IPOD are tightly packed, in-soluble and don't exchange with the cytosol. Amyloidogenic proteins, such as the Huntingtin protein, are the IPOD's substrates. Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD. Ubiquitination of an otherwise IPOD substrate, such as the RNQ1 fungal prion, will result in its sequestration in the JUNQ inclusion. Upon accumulation of misfolded proteins,