Aquae Calidae, Bulgaria well as from Kabyle, Mesambria (now Nessebar), Odessos, Histria, Tomis, Byzantium, Abdera, Maroneia and the islands of the Aegean, the oldest from Apollonia Pontica from the 5th century BC. The first baths at the Sanctuary of the Three Nymphs originated when the Roman Empire under Lucullus conquered the region, during the Third Mithridatic War in 72 BC. Under Trajan (98-117) nearby Anchialos became the administrative centre of the region and the baths were expanded and extended with two more swimming pools. During this time the Via Pontica was built connecting Constantinople via Deultum, Anchialos, Aquae Calidae with Dorostorum and Sexaginta
Aphanizomenon flos-aquae samples exceeded the safety value of 1 µg microcystin per gram. University professor Daniel Dietrich warned parents not to let children consume "A. flos-aquae" products, since children are even more vulnerable to toxic effects, due to lower body weight, and the continuous intake might lead to accumulation of toxins. Dietrich also warned against quackery schemes selling these cyanobacteria as medicine against illnesses such as attention deficit hyperactivity disorder, causing people to omit their regular drugs. A Canadian study studying the effect of "A. flos-aquae" on the immune and endocrine systems, as well as on general blood physiology, found that eating