Lady Writing a Letter with her Maid painting's canvas was almost certainly cut from the same bolt used for "Woman with a Lute". "Lady Writing a Letter with her Maid" is the first of the artist's experiments with centrifugal composition; where the focus is not only from the centre of the canvas. In addition, it is his third work in which the drama and dynamic is not centred on a single figure. The maid is shown standing in the mid-ground, behind her lady, with her hands crossed and waiting for the letter to be completed. The positions of their bodies indicate that the two women are disconnected.
Columbus's letter on the first voyage was also accused, but he was soon extricated by his employer, King Ferdinand II. Perhaps not coincidentally, another of the persons implicated in the conspiracy was the uncle of Leander Cosco, the Latin translator of Columbus's letter to Sanchez, who may himself have been a relative to the Sanchez clan. Gabriel's brother Juan Sanchez set himself up in Florence as a merchant, and is known to have received a copy of Columbus's letter from Gabriel Sanchez, which commissioned to be translated into Italian (only a partial fragment survives, see below). One of Gabriel's nephews, also named Juan Sanchez, would later