IPhone officially announced and released on March 6, 2008, at the Apple Town Hall facility. It is a free download, with an Apple registration, that allows developers to develop native applications for the iPhone and iPod Touch, then test them in an "iPhone simulator". However, loading an application onto a real device is only possible after paying an Apple Developer Connection membership fee. Developers are free to set any price for their applications to be distributed through the App Store, of which they will receive a 70% share. Developers can also opt to release the application for free and will not
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling