IPhone 5 Buena Center for the Arts in San Francisco on September 12, 2012. A shadow of the numeral 5 was featured in the invitations sent to the media, suggesting that the next iPhone would be unveiled at the event. At the unveiling, Apple announced the iPhone 5 and also introduced new iPod Nano and iPod Touch models. They also stated that pre-orders would be accepted starting September 14, 2012. Over two million pre-orders were received within 24 hours. Initial demand for the new phone exceeded the record set by its predecessor, the iPhone 4s, by selling over 5 million units in
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling