IPod Nano game was dropped and replaced with a Maze game which makes use of the iPod's accelerometer similarly to such games on the iPhone and iPod Touch. The fourth generation dropped support for charging via FireWire. "This change means that any dock accessories that use the dock connector's FireWire pins to send power—many older speakers and car chargers, for example—will not charge the fourth-generation iPod Nano." At Apple's September 9, 2009 event, a fifth generation iPod Nano was unveiled with reduced prices on the larger model (at the time of release, the 8GB was priced at $149 and the 16GB at
JUNQ and IPOD IPOD may serve not only as a sequestration site, but also as a functional compartment. The IPOD is a non- membrane bound cellular site, which in yeast is located by the vacuole. FRAP and FLIP assays revealed that proteins in the IPOD are tightly packed, in-soluble and don't exchange with the cytosol. Amyloidogenic proteins, such as the Huntingtin protein, are the IPOD's substrates. Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD. Ubiquitination of an otherwise IPOD substrate, such as the RNQ1 fungal prion, will result in its sequestration in the JUNQ inclusion. Upon accumulation of misfolded proteins,