Tap Tap Revenge the second-most downloaded free application of the year from their App Store, and the most downloaded free game. In April 2009, internet marketing research company comScore announced the results of a study which claimed 1 in 3 U.S. iPhone OS users had downloaded the game, and that it was the most popular application for the iPhone and iPod Touch. As part of the 2nd generation iPod touch advertising campaign, Apple featured "Tap Tap Revenge" in print and television ads with the headline "The funnest iPod ever.". The game spawned three direct sequels, "Tap Tap Revenge 2", "Tap Tap Revenge 3",
JUNQ and IPOD the late onset of neurodegenerative diseases. In such diseases (e.g. Huntington's disease), a mutated protein misfolds and becomes toxic to the cellular environment by various ways such as denaturating cytosolic proteins. Incompetent of degrading those toxic species, the cell must isolate them to avoid their hazardous interaction with the cellular proteome. The IPOD was shown to be the sub-cellular site to which toxic amyloidogenic proteins are sequestered to, hereby serving as a protective quality control compartment. In addition, it was suggested by the Lindquist group, that the IPOD is the site where yeast prions undergo a maturation process. Thus, the