IPhone 5C the first three days, which set a record for first weekend smartphone sales, with the 5S selling three times more units than iPhone 5C. After the first day of release, 1% of all iPhone in the US were iPhone 5S, while 0.3% were iPhone 5C.<ref name="cnet iP5S/C sales 1"></ref> Commentators viewed iPhone 5C as a flop because of supply chain cuts signifying a decline in demand in October 2013. Apple CEO Tim Cook admitted that the company overstocked the iPhone 5C while having shortages of the iPhone 5S, as a result of failing to anticipate the sales ratio between both
JUNQ and IPOD IPOD may serve not only as a sequestration site, but also as a functional compartment. The IPOD is a non- membrane bound cellular site, which in yeast is located by the vacuole. FRAP and FLIP assays revealed that proteins in the IPOD are tightly packed, in-soluble and don't exchange with the cytosol. Amyloidogenic proteins, such as the Huntingtin protein, are the IPOD's substrates. Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD. Ubiquitination of an otherwise IPOD substrate, such as the RNQ1 fungal prion, will result in its sequestration in the JUNQ inclusion. Upon accumulation of misfolded proteins,