IPhone its older iPhones when issuing operating system upgrades. It has spurred allegations that the firm has been using this as a tactic to prompt users of older iPhones to buy newer models. Up to the iPhone 4, all iPhone models, as well as other iOS devices were manufactured exclusively by Foxconn, based in Taiwan. In 2011, after Tim Cook became CEO of the company, Apple changed its outsourcing strategy, for the first time increasing its supply partners. The iPhone 4s in 2012 was the first model which was manufactured simultaneously by two stand-alone companies: Foxconn as well as Pegatron, also
JUNQ and IPOD the late onset of neurodegenerative diseases. In such diseases (e.g. Huntington's disease), a mutated protein misfolds and becomes toxic to the cellular environment by various ways such as denaturating cytosolic proteins. Incompetent of degrading those toxic species, the cell must isolate them to avoid their hazardous interaction with the cellular proteome. The IPOD was shown to be the sub-cellular site to which toxic amyloidogenic proteins are sequestered to, hereby serving as a protective quality control compartment. In addition, it was suggested by the Lindquist group, that the IPOD is the site where yeast prions undergo a maturation process. Thus, the