IPhone OS 2 Apple II and Mac as one of the great revolutions in modern technology. It takes it beyond simple Phone + iPod, or even smartphone, and makes it the leading contender for the next great shift in computing." However, they criticized it for having stability issues and overall sluggishness. "Macworld" said, "The iPhone 2.0 software is full of the kind of refinements that you’d expect from a second-generation Apple product. The iPhone OS still isn’t perfect, and we wish Apple has addressed some lingering shortcomings, but it’s a welcome step-up for what was already arguably the best mobile platform on the
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling