IPod Shuffle September 10, 2013, to coincide with the release of the iPhone 5S, the "Slate" color option was replaced with "Space Grey". On July 15, 2015, Apple released 6 new colors (blue, pink, silver, gold, space grey, and Product Red) for the iPod Shuffle. On July 27, 2017, Apple announced that it is discontinuing the iPod shuffle along with the iPod Nano. The iPod Shuffle was announced at the same time as the Mac Mini. Like the iPod Shuffle, the Mac Mini is a scaled-down product which has been introduced at a lower price. These two products together can be seen
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling