IPhone 4S due to the relatively aged hardware. In fact, some users often reported that performance on the 4S is very slow, similar to how iOS 7 ran on the iPhone 4, and suggesting that they should not upgrade due to battery draining issues and hanging up on calls. Meanwhile, Apple released iOS 8.1.1, which brought slight improvements to the phone and the iPad 2, but it still did not run as fast as newer models. On June 8, 2015, Apple announced at the WWDC that the iPhone 4S would support iOS 9. This makes it the first iPhone to support 5
JUNQ and IPOD the disaggregase chaperone, AAA protein HSP104, localizes to the IPOD. It is yet to be determined if HSP104 functions in the IPOD or is simply sequestered there being hooked to a substrate. The pre-autophagosomal structure (PAS) is localized by the IPOD. However, it wasn't shown that IPOD substrates are delivered to the vacuole, and so the link between the IPOD and autophagy is yet to be determined. JUNQ and IPOD JUNQ and IPOD are types of cytosolic protein inclusion bodies in eukaryotes. Neurodegenerative diseases, such as Parkinson's, Alzheimer's, and Huntington's, are associated and correlated with protein aggregation and accumulation of