Tap Tap Revenge the second-most downloaded free application of the year from their App Store, and the most downloaded free game. In April 2009, internet marketing research company comScore announced the results of a study which claimed 1 in 3 U.S. iPhone OS users had downloaded the game, and that it was the most popular application for the iPhone and iPod Touch. As part of the 2nd generation iPod touch advertising campaign, Apple featured "Tap Tap Revenge" in print and television ads with the headline "The funnest iPod ever.". The game spawned three direct sequels, "Tap Tap Revenge 2", "Tap Tap Revenge 3",
JUNQ and IPOD and processing of different kinds of misfolded proteins (e.g. ubiquitinated vs. non-ubiquitinated proteins). Segregation of toxic protein aggregates into JUNQ and IPOD inclusion bodies is a means by which mammalian cells can be rejuvenated through asymmetric division. Thus, the discovery of JUNQ and IPOD provided a new striking perspective of how cells manage misfolded aggregated proteins and gave convincing proof that protein aggregation is a non-random, well regulated and controlled cellular process. Furthermore, the discovery of JUNQ and IPOD suggested that in addition to temporal quality control (i.e. time dependent administration of damaged proteins) cells exploit homeostasis spatially: If degradation