History of Strasbourg remained neutral during the Thirty Years' War (1618-1648), and retained its status as a Free Imperial City. However, the city was later annexed by Louis XIV of France to extend the borders of his kingdom. Louis' advisors believed that, as long as Strasbourg remained independent, it would endanger the King's newly annexed territories in Alsace, and, that to defend these large rural lands effectively, a garrison had to be placed in towns such as Strasbourg. Indeed, the bridge over the Rhine at Strasbourg had been used repeatedly by Imperial (Holy Roman Empire) forces, and three times during the Franco-Dutch War
Strasbourg and home to 13% of the Grand Est region's inhabitants. The transnational Eurodistrict Strasbourg-Ortenau had a population of 915,000 inhabitants in 2014. Strasbourg is one of the "de facto" capitals of the European Union (alongside Brussels and Luxembourg), as it is the seat of several European institutions, such as the Council of Europe (with its European Court of Human Rights, its European Directorate for the Quality of Medicines and its European Audiovisual Observatory) and the Eurocorps, as well as the European Parliament and the European Ombudsman of the European Union. The city is also the seat of the Central Commission