Tap Tap Revenge the second-most downloaded free application of the year from their App Store, and the most downloaded free game. In April 2009, internet marketing research company comScore announced the results of a study which claimed 1 in 3 U.S. iPhone OS users had downloaded the game, and that it was the most popular application for the iPhone and iPod Touch. As part of the 2nd generation iPod touch advertising campaign, Apple featured "Tap Tap Revenge" in print and television ads with the headline "The funnest iPod ever.". The game spawned three direct sequels, "Tap Tap Revenge 2", "Tap Tap Revenge 3",
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling