IPod Shuffle on second-generation iPod Shuffles. On October 26, 2006, Apple released an iPod Shuffle Reset Utility that corrected this problem for some owners of first-generation iPod Shuffles. Then, in March 2007, an updated iPod Reset Utility was released which can also address similar problems with second-generation iPod Shuffles. Unlike most other portable audio players, the third-generation iPod Shuffle's controls are situated on the packaged headphones. The user is unable to control the device unless they use either Apple headphones designed for it, or third-party headphones or adapters that must be licensed by Apple. The third generation iPod Shuffle's headphones contain a
JUNQ and IPOD IPOD may serve not only as a sequestration site, but also as a functional compartment. The IPOD is a non- membrane bound cellular site, which in yeast is located by the vacuole. FRAP and FLIP assays revealed that proteins in the IPOD are tightly packed, in-soluble and don't exchange with the cytosol. Amyloidogenic proteins, such as the Huntingtin protein, are the IPOD's substrates. Misfolded proteins must be non-ubiquitinated to be sorted to the IPOD. Ubiquitination of an otherwise IPOD substrate, such as the RNQ1 fungal prion, will result in its sequestration in the JUNQ inclusion. Upon accumulation of misfolded proteins,