IPhone 5C the first three days, which set a record for first weekend smartphone sales, with the 5S selling three times more units than iPhone 5C. After the first day of release, 1% of all iPhone in the US were iPhone 5S, while 0.3% were iPhone 5C.<ref name="cnet iP5S/C sales 1"></ref> Commentators viewed iPhone 5C as a flop because of supply chain cuts signifying a decline in demand in October 2013. Apple CEO Tim Cook admitted that the company overstocked the iPhone 5C while having shortages of the iPhone 5S, as a result of failing to anticipate the sales ratio between both
JUNQ and IPOD that protein aggregation may actually be a tightly regulated, organized process, by which the cell protects itself from toxic proteins by sequestration to inclusion bodies. In 2008, Daniel Kaganovich showed that eukaryotic cells sort misfolded proteins into two distinct inclusion bodies in a well-managed cellular process: JUNQ and IPOD are evolutionarily conserved, and are found in specific and defined cellular sites. Delivery of misfolded, aggregated proteins to JUNQ and IPOD require an intact cytoskeleton and specific cellular quality control components, such as Heat Shock Proteins (HSPs). The partition into the two distinct inclusion bodies is due to the different handling