Aquae Calidae, Bulgaria well as from Kabyle, Mesambria (now Nessebar), Odessos, Histria, Tomis, Byzantium, Abdera, Maroneia and the islands of the Aegean, the oldest from Apollonia Pontica from the 5th century BC. The first baths at the Sanctuary of the Three Nymphs originated when the Roman Empire under Lucullus conquered the region, during the Third Mithridatic War in 72 BC. Under Trajan (98-117) nearby Anchialos became the administrative centre of the region and the baths were expanded and extended with two more swimming pools. During this time the Via Pontica was built connecting Constantinople via Deultum, Anchialos, Aquae Calidae with Dorostorum and Sexaginta
Aphanizomenon flos-aquae (dietary supplement) and sun exposure can greatly affect lipid and pigment composition. As more is learned about the components of different cyanobacterial species, growers and harvesters are better able to determine the optimal growth conditions for obtaining optimal yields. " Aphanizomenon flos-aquae" has been shown to contain varying amounts at least 13 vitamins: vitamin A (beta-carotene), vitamin C (ascorbic acid), vitamin E, vitamin K, and many of the B-complex vitamins including B (thiamin), B (riboflavin), B (pyridoxine), choline, biotin, niacin, folic acid, pantothenic acid, and B (cobalamin). However, "Aphanizomenon flos-aquae" contains pseudovitamin B which can block absorbtion of true B and is