Lorraine Heggessey involved in the dismissal of "Blue Peter" presenter Richard Bacon. In October 1998, the "News of the World" newspaper revealed that Bacon had taken cocaine, and he was subsequently sacked from his job as a presenter on the high-profile children's programme. Heggessey appeared on-screen in a specially-recorded one-minute address to viewers shown directly before the first episode of "Blue Peter" to be screened following Bacon's sacking, on 19 October 1998, to explain to young viewers why Bacon had been dismissed, claiming that he had "not only let himself and the team on "Blue Peter" down, but he has also let
Epigenetics of cocaine addiction of cocaine. Conversely, an increase of CREB was shown to decrease the rewarding effects of cocaine. Zhang et al. also used microarrays to identify specific genes induced by chronic cocaine use, which depend on a functional D1 receptor 24 hours after cocaine withdrawal. There were 109 genes identified that were either up or down regulated by 1.2 fold or more in the caudate putamen D1 receptor mutant mice after repeat injections. The expression of these genes was totally normal in mice with functional D1 receptors, suggesting chronic cocaine use had a direct influence on mediating these genes through a functional