Egon Spengler is not so much ashamed as "strongly" considers irrelevant, mainly because he sees science as relevant. Spengler's faith in science was also tested in one episode where the Ghostbusters get abducted to the ghost world by the ghost of Al Capone. Spengler's scientific equipment fails until he is told by former capos of Capone (who aid the Ghostbusters in revenge for Capone double-crossing them) that only magic can harm ghosts in the ghost world as opposed to science harming ghosts in the human world, thus forcing Spengler to accept the wizardry methods of his ancestors to defeat Capone. He is
Pictet–Spengler reaction Pictet–Spengler reaction The Pictet–Spengler reaction is a chemical reaction in which a β-arylethylamine undergoes condensation with an aldehyde or ketone followed by ring closure. The reaction was first discovered in 1911 by Amé Pictet and Theodor Spengler. Traditionally an acidic catalyst in protic solvent was employed with heating, however the reaction has been shown to work in aprotic media without acid catalysis in superior yields for a variety of cases. The Pictet–Spengler reaction can be considered a special case of the Mannich reaction, which follows a similar reaction pathway. The driving force for this reaction is the electrophilicity of the