Egon Spengler the love interest of Janine Melnitz, the Ghostbusters' secretary, in the first film and both animated series ("Ghostbusters II" excluded their romance due to Ramis' dislike of the subplot, thus having Melnitz date Louis Tully instead). Spengler sometimes appears to be unaware of Melnitz's romantic interest in him, but at times he displays having similar feelings for her, such as when he gave her a geranium as a gift when she expressed an interest in plants (which backfired horribly when it was revealed that the geranium was possessed by a ghost and nearly destroyed her apartment, along with much of
Pictet–Spengler reaction is created. Several substrate- or auxiliary-controlled diastereoselective Pictet–Spengler reactions have been developed. Additionally, List "et al." have published a chiral Brønsted acid that catalyzes asymmetric Pictet–Spengler reactions. Tryptophans: diastereocontrolled reaction The reaction of enantiopure tryptophan or its short-chain alkylesters leads to 1,2,3,4-tetrahydro-"β"-carbolines in which a new chiral center at C-1 adopts either a "cis" or "trans" configuration towards the C-3 carboxyl group. The "cis" conduction is kinetically controlled, i.e. it is performed at lower temperatures. At higher temperatures the reaction becomes reversible and usually favours racemisation. 1,3-"trans" dominated products can be obtained with "N"-benzylated tryptophans, which are accessible by reductive