Egon Spengler the city, after the digging of a new subway tunnel resulted in the release of an ancient ghost, Spengler was forced to recruit his only four current students to act as the new Ghostbusters. Although willing to do his share of the legwork, Spengler overestimates his abilities and his aging becomes apparent when he is no longer able to work at the same level as in his younger days, generally working at the firehouse doing research while the team handle the actual 'Ghostbusting', though when the situation calls for it he will help. Melnitz is still carrying a torch for
Pictet–Spengler reaction amination. The benzyl group can be removed hydrogenolytically afterwards. As a rough rule, C NMR signals for C1 and C3 are downfield shifted in "cis" products relative to "trans" products (see steric compression effect). Pictet–Spengler reaction The Pictet–Spengler reaction is a chemical reaction in which a β-arylethylamine undergoes condensation with an aldehyde or ketone followed by ring closure. The reaction was first discovered in 1911 by Amé Pictet and Theodor Spengler. Traditionally an acidic catalyst in protic solvent was employed with heating, however the reaction has been shown to work in aprotic media without acid catalysis in superior yields for