Egon Spengler It is implied in one episode of the animated series that Spengler accidentally burned down his family's garage. Spengler is the only original Ghostbuster to return for the "Extreme Ghostbusters" series as a regular, acting as a mentor to the new Ghostbusters (the others appeared for a two-part episode, "Back in the Saddle"), and monitoring and sustaining the Containment Unit while working as a paranormal studies professor at a university. He is the de facto leader of the new, younger team of Ghostbusters; although the old team had gone into retirement after they apparently dealt with all the ghosts in
Pictet–Spengler reaction imine generated from the condensation of the aldehyde and amine. This helps to explain the need for an acidic medium in some substrates, as the imine may not be electrophilic enough for ring closure to occur but the Iminium ion is capable of undergoing the reaction. The Pictet-Spengler reaction is widespread in both human industry and biosynthesis. It has remained an important reaction in the fields of alkaloid and pharmaceutical synthesis since its inception, where it has been employed in the development of many beta-carbolines. The enzyme strictosidine synthase is an example of nature utilizing the Pictet-Spengler reaction, which generates