Trimethylamine N-oxide Trimethylamine N-oxide Trimethylamine "N"-oxide (TMAO) is an organic compound with the formula (CH)NO. It is in the class of amine oxides. Although the anhydrous compound is known, trimethylamine "N"-oxide is usually encountered as the dihydrate. It is a product of the oxidation of trimethylamine, a common metabolite in animals. Both the anhydrous and hydrated materials are white, water-soluble solids. Trimethylamine "N"-oxide is an osmolyte found in saltwater fishes, sharks, rays, molluscs, and crustaceans. It is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays. It is also higher in deep-sea
I Should Have Known Better It was not released as a single at that time. In 1976, it was released as a B-side to "Yesterday". In the US, "I Should Have Known Better" was released on 13 July 1964 as the B-side to "A Hard Day's Night" and reached number 53 in the "Billboard" Hot 100, and number 43 on the "Cash Box" chart. As part of the film contract, United Artists acquired album rights for the American market. The company released a soundtrack album on 26 June 1964 with eight Beatles songs and four instrumentals. "I Should Have Known Better" was performed in the