Andy Roddick was the Artois Championship, his annual Wimbledon preparation, where he was the defending champion. Roddick defeated Mardy Fish and Andy Murray, before losing to eventual champion Rafael Nadal in the semifinals. At Wimbledon, Roddick was beaten by Serbia's Janko Tipsarević. This was his earliest exit at Wimbledon. Roddick was beaten at the Rogers Cup in the third round by Marin Čilić. He was then forced to pull out of the Cincinnati Masters following a neck injury, which he said may have been caused by a poor sleeping posture. He stated in an interview that the neck injury had nothing to
Andy Roddick fourth round, before being upset by unseeded and eventual finalist, Marcos Baghdatis. At the French Open, Roddick retired in the first round, after sustaining a foot injury during the match. Two weeks later at Wimbledon, Roddick was upset in the third round by British hopeful Andy Murray. This loss caused Roddick to fall below the top 10 for the first time since 2002. After Wimbledon, Roddick began working with a new coach, tennis legend Jimmy Connors. In his first event with his new coach, Roddick reached the final of Indianapolis, before losing to good friend and fellow American, James Blake.