Egon Spengler a P.K.E. surge of dangerous proportions. Egon was particularly critical of Walter Peck's actions, and his attitude that the Ghostbusters were responsible for the explosion of the containment unit that occurred when Peck ordered a municipal worker to shut the unit down. After their encounter with Stay Puft, Egon suggested an atypical solution when he recommended blasting Gozer's dimensional portal while crossing the proton streams to reverse the particle flow and send Gozer back to his/its dimension. Egon once tried to drill a hole in his own head (a process known as trepanning), which he says "would have worked" if
Pictet–Spengler reaction hydrochloric acid forming a tetrahydroisoquinoline. Like the Mannich reaction, aldehydes give good yields while ketones tend to give lower conversion. The Pictet–Spengler reaction has been applied to solid-phase combinatorial chemistry with great success. An analogous reaction with an aryl-β-ethanol is called Oxa-Pictet–Spengler reaction The reaction mechanism occurs by initial formation of an iminium ion (2) followed by electrophilic addition at the 3-position, in accordance with the expected nucleophilicity of indoles, to give the spirocycle 3. After migration of the best migrating group, deprotonation gives the product (5). Replacing an indole with a 3,4-dimethoxyphenyl group give the reaction named the Pictet–Spengler