Extreme Ghostbusters Extreme Ghostbusters Extreme Ghostbusters is an American animated television series and a follow-up to the animated series "The Real Ghostbusters". It is a part of the "Ghostbusters" franchise. The series originally aired in late 1997, and features a team of younger college-level Ghostbusters who are led by veteran Ghostbuster Egon Spengler. In some TV listings, the show was called "Ghostbusters Dark". Set years after the end of "The Real Ghostbusters", lack of supernatural activity has put the Ghostbusters out of business. Each member has gone their separate way, except for Dr. Egon Spengler, who still lives in the firehouse to
Pictet–Spengler reaction hydrochloric acid forming a tetrahydroisoquinoline. Like the Mannich reaction, aldehydes give good yields while ketones tend to give lower conversion. The Pictet–Spengler reaction has been applied to solid-phase combinatorial chemistry with great success. An analogous reaction with an aryl-β-ethanol is called Oxa-Pictet–Spengler reaction The reaction mechanism occurs by initial formation of an iminium ion (2) followed by electrophilic addition at the 3-position, in accordance with the expected nucleophilicity of indoles, to give the spirocycle 3. After migration of the best migrating group, deprotonation gives the product (5). Replacing an indole with a 3,4-dimethoxyphenyl group give the reaction named the Pictet–Spengler