Egon Spengler It is implied in one episode of the animated series that Spengler accidentally burned down his family's garage. Spengler is the only original Ghostbuster to return for the "Extreme Ghostbusters" series as a regular, acting as a mentor to the new Ghostbusters (the others appeared for a two-part episode, "Back in the Saddle"), and monitoring and sustaining the Containment Unit while working as a paranormal studies professor at a university. He is the de facto leader of the new, younger team of Ghostbusters; although the old team had gone into retirement after they apparently dealt with all the ghosts in
Pictet–Spengler reaction Pictet–Spengler reaction The Pictet–Spengler reaction is a chemical reaction in which a β-arylethylamine undergoes condensation with an aldehyde or ketone followed by ring closure. The reaction was first discovered in 1911 by Amé Pictet and Theodor Spengler. Traditionally an acidic catalyst in protic solvent was employed with heating, however the reaction has been shown to work in aprotic media without acid catalysis in superior yields for a variety of cases. The Pictet–Spengler reaction can be considered a special case of the Mannich reaction, which follows a similar reaction pathway. The driving force for this reaction is the electrophilicity of the