Extreme Ghostbusters Extreme Ghostbusters Extreme Ghostbusters is an American animated television series and a follow-up to the animated series "The Real Ghostbusters". It is a part of the "Ghostbusters" franchise. The series originally aired in late 1997, and features a team of younger college-level Ghostbusters who are led by veteran Ghostbuster Egon Spengler. In some TV listings, the show was called "Ghostbusters Dark". Set years after the end of "The Real Ghostbusters", lack of supernatural activity has put the Ghostbusters out of business. Each member has gone their separate way, except for Dr. Egon Spengler, who still lives in the firehouse to
Pictet–Spengler reaction tetrahydroisoquinoline synthesis. Reaction conditions are generally harsher than the indole variant, and require refluxing conditions with strong acids like hydrochloric acid, trifluoroacetic acid or superacids. Instead of catalyzing the Pictet-Spengler cyclization with strong acid, one can acylate the iminium ion forming the intermediate "N"-acyliminium ion. The "N"-acyliminium ion is a very powerful electrophile and most aromatic ring systems will cyclize under mild conditions with good yields. Tadalafil is synthesized via the "N"-acyliminium Pictet–Spengler reaction. This reaction can also be catalyzed by AuCl and AgOTf. When the Pictet–Spengler reaction is performed with an aldehyde other than formaldehyde, a new chiral center