Egon Spengler Brooklyn; though Spengler managed to thwart the ghost, Melnitz angrily told Spengler he would have to pay for the damages to her home) and when he rushed to her rescue in "Janine, You've Changed"; he also embraces her in "Ghost Busted" after she was kidnapped and held for ransom by a gangster, and became jealous when she was briefly involved with a slimy businessman named Paul Smart. In the episode "Cry Uncle", Spengler's well-meaning but skeptical uncle Cyrus, visits him and, since he does not believe that Spengler's work with the Ghostbusters is real scientific work and therefore a waste
Pictet–Spengler reaction tetrahydroisoquinoline synthesis. Reaction conditions are generally harsher than the indole variant, and require refluxing conditions with strong acids like hydrochloric acid, trifluoroacetic acid or superacids. Instead of catalyzing the Pictet-Spengler cyclization with strong acid, one can acylate the iminium ion forming the intermediate "N"-acyliminium ion. The "N"-acyliminium ion is a very powerful electrophile and most aromatic ring systems will cyclize under mild conditions with good yields. Tadalafil is synthesized via the "N"-acyliminium Pictet–Spengler reaction. This reaction can also be catalyzed by AuCl and AgOTf. When the Pictet–Spengler reaction is performed with an aldehyde other than formaldehyde, a new chiral center