Egon Spengler the love interest of Janine Melnitz, the Ghostbusters' secretary, in the first film and both animated series ("Ghostbusters II" excluded their romance due to Ramis' dislike of the subplot, thus having Melnitz date Louis Tully instead). Spengler sometimes appears to be unaware of Melnitz's romantic interest in him, but at times he displays having similar feelings for her, such as when he gave her a geranium as a gift when she expressed an interest in plants (which backfired horribly when it was revealed that the geranium was possessed by a ghost and nearly destroyed her apartment, along with much of
Pictet–Spengler reaction imine generated from the condensation of the aldehyde and amine. This helps to explain the need for an acidic medium in some substrates, as the imine may not be electrophilic enough for ring closure to occur but the Iminium ion is capable of undergoing the reaction. The Pictet-Spengler reaction is widespread in both human industry and biosynthesis. It has remained an important reaction in the fields of alkaloid and pharmaceutical synthesis since its inception, where it has been employed in the development of many beta-carbolines. The enzyme strictosidine synthase is an example of nature utilizing the Pictet-Spengler reaction, which generates