Simon Thomas (presenter) 2:1 BA Hons degree in history. Having applied for the job three times, Thomas began presenting the children's programme "Blue Peter" on 8 January 1999 replacing the sacked presenter Richard Bacon. Previously he had worked as a runner at Children's BBC and the radio station LBC. During his tenure at "Blue Peter", he ran in the London Marathon twice and two Great North Runs, climbed Mount Kilimanjaro and Mont Blanc, completed over 40 solo sky dives with the Royal Air Force, presented a medal at the Commonwealth Games, ran in the 60 metres sprint at the Norwich Union Indoor Athletics
Cocaine intoxication hours after use. Epicardial coronary arteries are especially vulnerable to these effects, leading to decreased myocardial oxygen supply. Cocaine-induced platelet activation and thrombus formation is another deleterious effect, caused by alpha-adrenergic- and adenosine diphosphate-mediated increase in platelet aggregation. Plasminogen activator inhibitor is also increased following cocaine use, thereby promoting thrombosis. Similar to local anesthetics such as lidocaine, cocaine blocks sodium channels and interferes with action potential propagation. This Vaughn-Williams class IC effect increases the risk of conduction disturbance and tachyarrhythmias. Adding to its complex toxicity, cocaine targets muscarinic acetylcholine, N-methyl-D-aspartate (NMDA), sigma, and kappa-opioid receptors. Emergency treatment of cocaine-associated hyperthermia