Dihydrogen monoxide parody story has since been used in science education to encourage critical thinking and discussion of the scientific method. A 1983 April Fools' Day edition of the "Durand Express", a weekly newspaper in Durand, Michigan, reported that "dihydrogen oxide" had been found in the city's water pipes, and warned that it was fatal if inhaled, and could produce blistering vapors. The first appearance of the parody on the Internet was attributed by the "Pittsburgh Post-Gazette" to the so-called "Coalition to Ban Dihydrogen Monoxide", a parody organization at UC Santa Cruz following on-campus postings and newsgroup discussions in 1990. This new version
Nitric oxide could include impaired immune and respiratory function. NO is a gaseous signaling molecule. It is a key vertebrate biological messenger, playing a role in a variety of biological processes. It is a known bioproduct in almost all types of organisms, ranging from bacteria to plants, fungi, and animal cells. Nitric oxide, known as an endothelium-derived relaxing factor (EDRF), is biosynthesized endogenously from -arginine, oxygen, and NADPH by various nitric oxide synthase (NOS) enzymes. Reduction of inorganic nitrate may also serve to make nitric oxide. One of the main enzymatic targets of nitric oxide is guanylyl cyclase. The binding of nitric