Arsenic and Old Lace (film) Arsenic and Old Lace (film) Arsenic and Old Lace is a 1944 American dark comedy film directed by Frank Capra, starring Cary Grant, and based on Joseph Kesselring's play "Arsenic and Old Lace". The script adaptation was by Julius J. Epstein and Philip G. Epstein. Capra actually filmed the movie in 1941 because of star Cary Grant's availability, but it was not released until 1944, after the original stage version had finished its run on Broadway. The lead role of Mortimer Brewster was originally intended for Bob Hope, but he could not be released from his contract with Paramount Pictures.
Eps-Associated RNA element Eps-Associated RNA element The "eps"-Associated RNA element (EAR; also called "epsC" motif) is a conserved RNA motif associated with exopolysaccharide ("eps") or capsule biosynthesis genes in a subset of bacteria classified within the order Bacillales. It was initially discovered in "Bacillus subtilis", located between the second and third gene in the "eps" operon (i.e., between "epsB" and "epsC"). Deletion of the EAR element impairs biofilm formation. The combination of comparative sequence alignments and structural probing data revealed that the secondary structure of the EAR RNA consists of five helical segments (P1-P5) and a pseudoknot (see diagram). In general, mutations that