Trimethylamine N-oxide Trimethylamine N-oxide Trimethylamine "N"-oxide (TMAO) is an organic compound with the formula (CH)NO. It is in the class of amine oxides. Although the anhydrous compound is known, trimethylamine "N"-oxide is usually encountered as the dihydrate. It is a product of the oxidation of trimethylamine, a common metabolite in animals. Both the anhydrous and hydrated materials are white, water-soluble solids. Trimethylamine "N"-oxide is an osmolyte found in saltwater fishes, sharks, rays, molluscs, and crustaceans. It is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays. It is also higher in deep-sea
U Should've Known Better successful on "Billboard"´s component charts. It reached number 6 on the Hot R&B/Hip-Hop Singles & Tracks—Monica's tenth non-consecutive top ten entry on that particular chart—as well as the top ten on the Hot R&B/Hip-Hop Airplay and the top twenty on the Hot 100 Airplay chart. It also appeared on the Rhythmic Top 40 at number 20. The song was ranked 72nd on the Hot R&B/Hip-Hop Singles 2004 year-end chart. The music video for "U Should've Known Better" was shot by director Benny Boom, and produced by Joyce Washington for FM Rocks. It was filmed in various locations throughout Mexico, in