Transfer (association football) to Derby County for £24,000 in March 1949. The record was broken seven further times between 1949 and 1961, when Luis Suárez was sold by Barcelona to Inter Milan for £152,000, becoming the first ever player sold for more than £100,000. In 1968, Pietro Anastasi became the first £500,000 player when Juventus purchased him from Varese, which was followed seven years later with Giuseppe Savoldi becoming the first million pound player when he transferred from Bologna to Napoli. In English football, the first £1 million fee occurred in 1979, when Nottingham Forest signed striker Trevor Francis from Birmingham City. Later
Antigen transfer in the thymus manifestations of autoimmunity which points to their importance in central tolerance. Indeed, as mTECs represent exclusive "donors of TRAs", experiments with first antigen transfer mouse models discovered thymic dendritic cells (DCs) to be so far the only known "TRAs acceptors" involved in antigen transfer. Indispensability of DCs for the establishment of central tolerance was further verified by recent analysis, which revealed that DCs mediate both recessive and dominant tolerance, with preference for the latter, via presentation of more common TRAs. The most efficient subset in TRA presentation and both modes of central tolerance was found to be CD8α thymic-derived DCs