Egon Spengler Oswald Spengler and a classmate of Ramis at Senn High School, Egon Donsbach, a Hungarian refugee. Christopher Walken, John Lithgow, Christopher Lloyd and Jeff Goldblum were all considered for the role of Egon Spengler, before Ramis, who had gotten close to the character while writing him, felt compelled to play it himself. LaMarche stated that when he auditioned for the part of Spengler in "The Real Ghostbusters", he was asked not to do an impression of Ramis, which he ignored because impressions were one of his strengths as a performer, and there was no other way he could imagine properly
Pictet–Spengler reaction imine generated from the condensation of the aldehyde and amine. This helps to explain the need for an acidic medium in some substrates, as the imine may not be electrophilic enough for ring closure to occur but the Iminium ion is capable of undergoing the reaction. The Pictet-Spengler reaction is widespread in both human industry and biosynthesis. It has remained an important reaction in the fields of alkaloid and pharmaceutical synthesis since its inception, where it has been employed in the development of many beta-carbolines. The enzyme strictosidine synthase is an example of nature utilizing the Pictet-Spengler reaction, which generates