Andy Murray the victory to former player Elena Baltacha. He then lost to qualifier Santiago Giraldo in the following round. Murray then reached the quarter-finals of the Rome Masters where he lost to No. 1 Rafael Nadal in a tight match in which he had been up a break in the final set. At the French Open, Murray defeated Andrey Golubev and Marinko Matosevic before edging out 28th seed Philipp Kohlschreiber 12–10 in the final set. This was the first time Murray had ever gone beyond 7–5 in a deciding set. He followed this up with a straight sets win over Fernando
Andy Murray Ranked No. 312, Murray became the first Scot in the Open Era to reach the third round of the men's singles tournament at Wimbledon. In the third round, Murray lost to 2002 Wimbledon finalist David Nalbandian due to cramping and fatigue, having led two sets to love. Following Wimbledon, Murray won Challenger events on the hard courts of Aptos and Binghamton, New York. He then experienced his first Masters event at Cincinnati, where he beat Taylor Dent, before losing in three sets to then-No. 4, Marat Safin. With a wild card entry, Murray played Andrei Pavel in the opening round