Egon Spengler portraying the character other than to follow Ramis's example. He got the part anyway and said in an interview that he did two different takes: in which he impersonated Ramis, the other in which he tried a more "Woody Allen"-like approach that did not suit the character's physicality, he admitted. Egon Spengler is a tall, laconic, bespectacled, awkward member of the team responsible for the main theoretical framework for their paranormal/quantum studies. Being addicted to science, he is the creator of the Ghostbusters' equipment along with Raymond Stantz, thus making him the brains of the Ghostbusters. Although book smart, Spengler
Pictet–Spengler reaction hydrochloric acid forming a tetrahydroisoquinoline. Like the Mannich reaction, aldehydes give good yields while ketones tend to give lower conversion. The Pictet–Spengler reaction has been applied to solid-phase combinatorial chemistry with great success. An analogous reaction with an aryl-β-ethanol is called Oxa-Pictet–Spengler reaction The reaction mechanism occurs by initial formation of an iminium ion (2) followed by electrophilic addition at the 3-position, in accordance with the expected nucleophilicity of indoles, to give the spirocycle 3. After migration of the best migrating group, deprotonation gives the product (5). Replacing an indole with a 3,4-dimethoxyphenyl group give the reaction named the Pictet–Spengler