Alloy is sometimes a result of the sizes of the atoms in the alloy, because larger atoms exert a compressive force on neighboring atoms, and smaller atoms exert a tensile force on their neighbors, helping the alloy resist deformation. Sometimes alloys may exhibit marked differences in behavior even when small amounts of one element are present. For example, impurities in semiconducting ferromagnetic alloys lead to different properties, as first predicted by White, Hogan, Suhl, Tian Abrie and Nakamura. Some alloys are made by melting and mixing two or more metals. Bronze, an alloy of copper and tin, was the first alloy
Antimicrobial copper-alloy touch surfaces in rooms with copper touch surfaces were significantly lower than in rooms without copper surfaces. "Staphylococci" were the most predominant microorganism isolated and copper was effective in reducing the "Staphylococci" microbial burden. Further studies regarding the clinical implications of copper's intrinsic ability to reduce microbial burdens in hospitals are being planned. Researchers from the Kitasato University School of Medicine conducted antimicrobial studies of "S. aureus", "E. coli", and "P. aeruginosa" on various Japanese copper alloy coins and on copper alloy plates. The microbes were strains from hospital environments. Copper and its nickel-silver, cupronickel, and brass alloys were found to kill