Trimethylamine N-oxide Trimethylamine N-oxide Trimethylamine "N"-oxide (TMAO) is an organic compound with the formula (CH)NO. It is in the class of amine oxides. Although the anhydrous compound is known, trimethylamine "N"-oxide is usually encountered as the dihydrate. It is a product of the oxidation of trimethylamine, a common metabolite in animals. Both the anhydrous and hydrated materials are white, water-soluble solids. Trimethylamine "N"-oxide is an osmolyte found in saltwater fishes, sharks, rays, molluscs, and crustaceans. It is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays. It is also higher in deep-sea
I Should Have Known Better solo) and thus draws a line under a significant period of their early music. The song's middle sixteen section features George Harrison's brand new Rickenbacker 360/12 12-string guitar. The mono and stereo versions have slightly different harmonica introductions. In the stereo version, the harmonica drops out briefly. Also, a noticeably clumsy and audible tape edit is heard during the second chorus between "You're gonna say you love me too, oh," and "And when I ask you to be mine." In the UK, "I Should Have Known Better" appeared on "A Hard Day's Night" and was released on 10 July 1964.