Egon Spengler fraud, violating their judicial restraining order, and malicious mischief by judge Stephen Wexler (whom Egon said was known as "The Hammer"). While angrily insulting the trio judge Wexler inadvertently released the ghosts of the Scoleri Brothers; two murderers he sentenced to death by the electric chair. During the chaos judge Wexler dismisses the charges against the Ghostbusters, and rescinds the judicial restraining order allowing Egon, Ray, and Peter to capture the ghosts, effectively putting the Ghostbusters back in business. Egon had a dry sense of humor, of which he used on Peter to bewilder him, and smirked at his friend's
Pictet–Spengler reaction is created. Several substrate- or auxiliary-controlled diastereoselective Pictet–Spengler reactions have been developed. Additionally, List "et al." have published a chiral Brønsted acid that catalyzes asymmetric Pictet–Spengler reactions. Tryptophans: diastereocontrolled reaction The reaction of enantiopure tryptophan or its short-chain alkylesters leads to 1,2,3,4-tetrahydro-"β"-carbolines in which a new chiral center at C-1 adopts either a "cis" or "trans" configuration towards the C-3 carboxyl group. The "cis" conduction is kinetically controlled, i.e. it is performed at lower temperatures. At higher temperatures the reaction becomes reversible and usually favours racemisation. 1,3-"trans" dominated products can be obtained with "N"-benzylated tryptophans, which are accessible by reductive