Egon Spengler sleeps an average of 14 minutes per day, leaving him "a lot of time to work." Egon was very interested in paranormal phenomena, even while working with Ray Stantz and Peter Venkman at the University. He and Ray Stantz studied paranormal literature in their spare time and were interested in theories of reincarnation. Egon was usually the first to interview case subjects, adding to their mantra, "we're ready to believe you." Examples were Dana Barrett from her Zuul encounter and her carriage phenomenon with Oscar. Even people Peter called "schizo" always went to either Egon or Ray to describe their
Pictet–Spengler reaction hydrochloric acid forming a tetrahydroisoquinoline. Like the Mannich reaction, aldehydes give good yields while ketones tend to give lower conversion. The Pictet–Spengler reaction has been applied to solid-phase combinatorial chemistry with great success. An analogous reaction with an aryl-β-ethanol is called Oxa-Pictet–Spengler reaction The reaction mechanism occurs by initial formation of an iminium ion (2) followed by electrophilic addition at the 3-position, in accordance with the expected nucleophilicity of indoles, to give the spirocycle 3. After migration of the best migrating group, deprotonation gives the product (5). Replacing an indole with a 3,4-dimethoxyphenyl group give the reaction named the Pictet–Spengler