Harold Ramis Dan Aykroyd on the screenplay for "Ghostbusters", which became one of the biggest comedy hits of all time, in which he also starred as Dr. Egon Spengler, a role he reprised for the 1989 sequel, "Ghostbusters II" (which he also co-wrote with Aykroyd). His later film "Groundhog Day" has been called his "masterpiece". His films have been noted for attacking "the smugness of institutional life ... with an impish good [will] that is unmistakably American". They are also noted for "Ramis's signature tongue-in-cheek pep talks". Sloppiness and improv were also important aspects of his work. Ramis frequently depicted the qualities
Pictet–Spengler reaction hydrochloric acid forming a tetrahydroisoquinoline. Like the Mannich reaction, aldehydes give good yields while ketones tend to give lower conversion. The Pictet–Spengler reaction has been applied to solid-phase combinatorial chemistry with great success. An analogous reaction with an aryl-β-ethanol is called Oxa-Pictet–Spengler reaction The reaction mechanism occurs by initial formation of an iminium ion (2) followed by electrophilic addition at the 3-position, in accordance with the expected nucleophilicity of indoles, to give the spirocycle 3. After migration of the best migrating group, deprotonation gives the product (5). Replacing an indole with a 3,4-dimethoxyphenyl group give the reaction named the Pictet–Spengler