Lorraine Heggessey involved in the dismissal of "Blue Peter" presenter Richard Bacon. In October 1998, the "News of the World" newspaper revealed that Bacon had taken cocaine, and he was subsequently sacked from his job as a presenter on the high-profile children's programme. Heggessey appeared on-screen in a specially-recorded one-minute address to viewers shown directly before the first episode of "Blue Peter" to be screened following Bacon's sacking, on 19 October 1998, to explain to young viewers why Bacon had been dismissed, claiming that he had "not only let himself and the team on "Blue Peter" down, but he has also let
Epigenetics of cocaine addiction but these other locations had no effect on the cocaine-seeking behavior of rats. The role of sirtuin deacetylases have also been shown to play a role in mediating cocaine addiction. To determine their role, the two transcription factors previously mentioned, ΔFosB and CREB, first had to be analyzed. It has been previously stated that ΔFosB increases the cocaine-seeking behavior of users. This is because ΔFosB has a uniquely stable structure that allows it to persist and accumulate in the body. Unlike ΔFosB, CREB is responsible for reducing sensitivity to cocaine which causes negative symptoms during the withdrawal period. Each of