Egon Spengler Brooklyn; though Spengler managed to thwart the ghost, Melnitz angrily told Spengler he would have to pay for the damages to her home) and when he rushed to her rescue in "Janine, You've Changed"; he also embraces her in "Ghost Busted" after she was kidnapped and held for ransom by a gangster, and became jealous when she was briefly involved with a slimy businessman named Paul Smart. In the episode "Cry Uncle", Spengler's well-meaning but skeptical uncle Cyrus, visits him and, since he does not believe that Spengler's work with the Ghostbusters is real scientific work and therefore a waste
Pictet–Spengler reaction is created. Several substrate- or auxiliary-controlled diastereoselective Pictet–Spengler reactions have been developed. Additionally, List "et al." have published a chiral Brønsted acid that catalyzes asymmetric Pictet–Spengler reactions. Tryptophans: diastereocontrolled reaction The reaction of enantiopure tryptophan or its short-chain alkylesters leads to 1,2,3,4-tetrahydro-"β"-carbolines in which a new chiral center at C-1 adopts either a "cis" or "trans" configuration towards the C-3 carboxyl group. The "cis" conduction is kinetically controlled, i.e. it is performed at lower temperatures. At higher temperatures the reaction becomes reversible and usually favours racemisation. 1,3-"trans" dominated products can be obtained with "N"-benzylated tryptophans, which are accessible by reductive