Progression of the British football transfer fee record to £142 million with various clauses being met. Progression of the British football transfer fee record The progression of the British football transfer fee record tracks the increases in the record for the highest transfer fee paid or received by British association football clubs. A transfer fee is the sum of money paid by one club to purchase the contract, and therefore the playing services, of a professional footballer. Fees are not generally formally disclosed by the clubs involved, and discrepancies can occur in figures quoted in the press. Trevor Francis, for example, is regarded as Britain's first £1m player
Antigen transfer in the thymus manifestations of autoimmunity which points to their importance in central tolerance. Indeed, as mTECs represent exclusive "donors of TRAs", experiments with first antigen transfer mouse models discovered thymic dendritic cells (DCs) to be so far the only known "TRAs acceptors" involved in antigen transfer. Indispensability of DCs for the establishment of central tolerance was further verified by recent analysis, which revealed that DCs mediate both recessive and dominant tolerance, with preference for the latter, via presentation of more common TRAs. The most efficient subset in TRA presentation and both modes of central tolerance was found to be CD8α thymic-derived DCs