Egon Spengler Oswald Spengler and a classmate of Ramis at Senn High School, Egon Donsbach, a Hungarian refugee. Christopher Walken, John Lithgow, Christopher Lloyd and Jeff Goldblum were all considered for the role of Egon Spengler, before Ramis, who had gotten close to the character while writing him, felt compelled to play it himself. LaMarche stated that when he auditioned for the part of Spengler in "The Real Ghostbusters", he was asked not to do an impression of Ramis, which he ignored because impressions were one of his strengths as a performer, and there was no other way he could imagine properly
Pictet–Spengler reaction is created. Several substrate- or auxiliary-controlled diastereoselective Pictet–Spengler reactions have been developed. Additionally, List "et al." have published a chiral Brønsted acid that catalyzes asymmetric Pictet–Spengler reactions. Tryptophans: diastereocontrolled reaction The reaction of enantiopure tryptophan or its short-chain alkylesters leads to 1,2,3,4-tetrahydro-"β"-carbolines in which a new chiral center at C-1 adopts either a "cis" or "trans" configuration towards the C-3 carboxyl group. The "cis" conduction is kinetically controlled, i.e. it is performed at lower temperatures. At higher temperatures the reaction becomes reversible and usually favours racemisation. 1,3-"trans" dominated products can be obtained with "N"-benzylated tryptophans, which are accessible by reductive