Egon Spengler him, which leaves him a little flustered. He celebrates his 40th birthday during this series, which would put him in his late twenties when "The Real Ghostbusters" began. Age is the largest factor causing Spengler to having transition from active ghost hunting to a mentorship role; in one episode where the original Ghostbusters guest starred on an episode the audience clearly sees middle adulthood has affected the speed and weakened the stamina of the original Ghostbusters. Although Egon Spengler does not appear in the 1990 "The Earth Day Special", his character and status as a Ghostbuster is mentioned, and Harold
Pictet–Spengler reaction is created. Several substrate- or auxiliary-controlled diastereoselective Pictet–Spengler reactions have been developed. Additionally, List "et al." have published a chiral Brønsted acid that catalyzes asymmetric Pictet–Spengler reactions. Tryptophans: diastereocontrolled reaction The reaction of enantiopure tryptophan or its short-chain alkylesters leads to 1,2,3,4-tetrahydro-"β"-carbolines in which a new chiral center at C-1 adopts either a "cis" or "trans" configuration towards the C-3 carboxyl group. The "cis" conduction is kinetically controlled, i.e. it is performed at lower temperatures. At higher temperatures the reaction becomes reversible and usually favours racemisation. 1,3-"trans" dominated products can be obtained with "N"-benzylated tryptophans, which are accessible by reductive