White Russian (cocktail) Kournikova (named after the tennis player, made with skimmed milk, i.e. a "skinny, low-fat" White Russian), a White Cuban (made with rum instead of vodka), or a Dirty Russian (made with chocolate milk instead of cream). White Russian (cocktail) A White Russian is a cocktail made with vodka, coffee liqueur (e.g., Kahlúa or Tia Maria), and cream served with ice in an Old Fashioned glass. Often milk will be used as an alternative to cream. The traditional cocktail known as a Black Russian, which first appeared in 1949, becomes a White Russian with the addition of cream. Neither drink is
Cooperstown cocktail Cooperstown cocktail The Cooperstown cocktail refers to a panel of four drug probes used in human pharmacokinetic studies to determine the activity of drug metabolising enzymes. The terminology 'cocktail' refers to the fact that the drug probes are given together. The Cooperstown cocktail consists of four drugs that are considered specific substrates for four cytochrome P450 (CYP) isoforms. One of the drugs (caffeine) provides, through its metabolites, substrates for two additional enzymes (see next paragraph). The drugs and the enzymes they probe are as follows - caffeine (probes CYP1A2, N-acetyltransferase 2, xanthine oxidase), midazolam (probes CYP3A), omeprazole (probes CYP2C19) and