Lorraine Heggessey involved in the dismissal of "Blue Peter" presenter Richard Bacon. In October 1998, the "News of the World" newspaper revealed that Bacon had taken cocaine, and he was subsequently sacked from his job as a presenter on the high-profile children's programme. Heggessey appeared on-screen in a specially-recorded one-minute address to viewers shown directly before the first episode of "Blue Peter" to be screened following Bacon's sacking, on 19 October 1998, to explain to young viewers why Bacon had been dismissed, claiming that he had "not only let himself and the team on "Blue Peter" down, but he has also let
Epigenetics of cocaine addiction to be induced by chronic cocaine administration (which had been true in the nucleus accumbens) but acute cocaine reduced expression in the caudate putamen whereas chronic cocaine injections decreased expression even in the NAc in D1 receptor mutants. This pathway influences Wrch1, so it can also influence cocaine-induced neuroadaptations. Lastly, they found that CaMKII-α was not upregulated as expected, and CD2 was downregulated in D1 receptor mutants after chronic treatment. These results suggest gene expression changes are definitely induced by chronic cocaine exposure via the D1 receptor and most at AP-1 binding sites. Contrary to most studies focusing on the