Egon Spengler sleeps an average of 14 minutes per day, leaving him "a lot of time to work." Egon was very interested in paranormal phenomena, even while working with Ray Stantz and Peter Venkman at the University. He and Ray Stantz studied paranormal literature in their spare time and were interested in theories of reincarnation. Egon was usually the first to interview case subjects, adding to their mantra, "we're ready to believe you." Examples were Dana Barrett from her Zuul encounter and her carriage phenomenon with Oscar. Even people Peter called "schizo" always went to either Egon or Ray to describe their
Pictet–Spengler reaction tetrahydroisoquinoline synthesis. Reaction conditions are generally harsher than the indole variant, and require refluxing conditions with strong acids like hydrochloric acid, trifluoroacetic acid or superacids. Instead of catalyzing the Pictet-Spengler cyclization with strong acid, one can acylate the iminium ion forming the intermediate "N"-acyliminium ion. The "N"-acyliminium ion is a very powerful electrophile and most aromatic ring systems will cyclize under mild conditions with good yields. Tadalafil is synthesized via the "N"-acyliminium Pictet–Spengler reaction. This reaction can also be catalyzed by AuCl and AgOTf. When the Pictet–Spengler reaction is performed with an aldehyde other than formaldehyde, a new chiral center