Hemingway Special Hemingway Special A Hemingway Special is an all day cocktail based on the Floridita Daiquiri and is recognised by the IBA. It is made with rum, lime juice, maraschino liqueur, and grapefruit juice and served in a double cocktail glass. While he was staying in Cuba, Ernest Hemingway tried the Floridita's signature drink, the Floridita Daiquiri, and said "That's good but I prefer it without sugar and double rum," creating a cocktail now known as the Hemingway Daiquiri or the Papa Doble. This recipe was later modified further, adding grapefruit juice to the mix, at which point the drink was
Cooperstown cocktail Cooperstown cocktail The Cooperstown cocktail refers to a panel of four drug probes used in human pharmacokinetic studies to determine the activity of drug metabolising enzymes. The terminology 'cocktail' refers to the fact that the drug probes are given together. The Cooperstown cocktail consists of four drugs that are considered specific substrates for four cytochrome P450 (CYP) isoforms. One of the drugs (caffeine) provides, through its metabolites, substrates for two additional enzymes (see next paragraph). The drugs and the enzymes they probe are as follows - caffeine (probes CYP1A2, N-acetyltransferase 2, xanthine oxidase), midazolam (probes CYP3A), omeprazole (probes CYP2C19) and