Egon Spengler Brooklyn; though Spengler managed to thwart the ghost, Melnitz angrily told Spengler he would have to pay for the damages to her home) and when he rushed to her rescue in "Janine, You've Changed"; he also embraces her in "Ghost Busted" after she was kidnapped and held for ransom by a gangster, and became jealous when she was briefly involved with a slimy businessman named Paul Smart. In the episode "Cry Uncle", Spengler's well-meaning but skeptical uncle Cyrus, visits him and, since he does not believe that Spengler's work with the Ghostbusters is real scientific work and therefore a waste
Pictet–Spengler reaction imine generated from the condensation of the aldehyde and amine. This helps to explain the need for an acidic medium in some substrates, as the imine may not be electrophilic enough for ring closure to occur but the Iminium ion is capable of undergoing the reaction. The Pictet-Spengler reaction is widespread in both human industry and biosynthesis. It has remained an important reaction in the fields of alkaloid and pharmaceutical synthesis since its inception, where it has been employed in the development of many beta-carbolines. The enzyme strictosidine synthase is an example of nature utilizing the Pictet-Spengler reaction, which generates