Alloy are relatively similar in size, the atom exchange method usually happens, where some of the atoms composing the metallic crystals are substituted with atoms of the other constituent. This is called a "substitutional alloy". Examples of substitutional alloys include bronze and brass, in which some of the copper atoms are substituted with either tin or zinc atoms respectively. In the case of the interstitial mechanism, one atom is usually much smaller than the other and can not successfully substitute for the other type of atom in the crystals of the base metal. Instead, the smaller atoms become trapped in the
Antimicrobial copper-alloy touch surfaces in rooms with copper touch surfaces were significantly lower than in rooms without copper surfaces. "Staphylococci" were the most predominant microorganism isolated and copper was effective in reducing the "Staphylococci" microbial burden. Further studies regarding the clinical implications of copper's intrinsic ability to reduce microbial burdens in hospitals are being planned. Researchers from the Kitasato University School of Medicine conducted antimicrobial studies of "S. aureus", "E. coli", and "P. aeruginosa" on various Japanese copper alloy coins and on copper alloy plates. The microbes were strains from hospital environments. Copper and its nickel-silver, cupronickel, and brass alloys were found to kill