Egon Spengler is not so much ashamed as "strongly" considers irrelevant, mainly because he sees science as relevant. Spengler's faith in science was also tested in one episode where the Ghostbusters get abducted to the ghost world by the ghost of Al Capone. Spengler's scientific equipment fails until he is told by former capos of Capone (who aid the Ghostbusters in revenge for Capone double-crossing them) that only magic can harm ghosts in the ghost world as opposed to science harming ghosts in the human world, thus forcing Spengler to accept the wizardry methods of his ancestors to defeat Capone. He is
Pictet–Spengler reaction is created. Several substrate- or auxiliary-controlled diastereoselective Pictet–Spengler reactions have been developed. Additionally, List "et al." have published a chiral Brønsted acid that catalyzes asymmetric Pictet–Spengler reactions. Tryptophans: diastereocontrolled reaction The reaction of enantiopure tryptophan or its short-chain alkylesters leads to 1,2,3,4-tetrahydro-"β"-carbolines in which a new chiral center at C-1 adopts either a "cis" or "trans" configuration towards the C-3 carboxyl group. The "cis" conduction is kinetically controlled, i.e. it is performed at lower temperatures. At higher temperatures the reaction becomes reversible and usually favours racemisation. 1,3-"trans" dominated products can be obtained with "N"-benzylated tryptophans, which are accessible by reductive