Jamie Murray first match at a Grand Slam since Wimbledon 2008 as they progressed to the second round of the Australian Open. Murray followed this up with two semi-final appearances, partnering Alexander Peya at the SA Open and his brother Andy at Rotterdam. These successes saw Murray climb back into the world top 50. At the French Open, Murray and his partner Chris Guccione were eliminated in the second round of the men's doubles by the top-seeded Bryans, but he progressed to the semi-finals of the mixed doubles with Nadia Petrova. In August, he reached the semi-finals of the Winston–Salem Open but
Andy Roddick fourth round, before being upset by unseeded and eventual finalist, Marcos Baghdatis. At the French Open, Roddick retired in the first round, after sustaining a foot injury during the match. Two weeks later at Wimbledon, Roddick was upset in the third round by British hopeful Andy Murray. This loss caused Roddick to fall below the top 10 for the first time since 2002. After Wimbledon, Roddick began working with a new coach, tennis legend Jimmy Connors. In his first event with his new coach, Roddick reached the final of Indianapolis, before losing to good friend and fellow American, James Blake.