Egon Spengler him, which leaves him a little flustered. He celebrates his 40th birthday during this series, which would put him in his late twenties when "The Real Ghostbusters" began. Age is the largest factor causing Spengler to having transition from active ghost hunting to a mentorship role; in one episode where the original Ghostbusters guest starred on an episode the audience clearly sees middle adulthood has affected the speed and weakened the stamina of the original Ghostbusters. Although Egon Spengler does not appear in the 1990 "The Earth Day Special", his character and status as a Ghostbuster is mentioned, and Harold
Pictet–Spengler reaction Pictet–Spengler reaction The Pictet–Spengler reaction is a chemical reaction in which a β-arylethylamine undergoes condensation with an aldehyde or ketone followed by ring closure. The reaction was first discovered in 1911 by Amé Pictet and Theodor Spengler. Traditionally an acidic catalyst in protic solvent was employed with heating, however the reaction has been shown to work in aprotic media without acid catalysis in superior yields for a variety of cases. The Pictet–Spengler reaction can be considered a special case of the Mannich reaction, which follows a similar reaction pathway. The driving force for this reaction is the electrophilicity of the