Simon Thomas (presenter) 2:1 BA Hons degree in history. Having applied for the job three times, Thomas began presenting the children's programme "Blue Peter" on 8 January 1999 replacing the sacked presenter Richard Bacon. Previously he had worked as a runner at Children's BBC and the radio station LBC. During his tenure at "Blue Peter", he ran in the London Marathon twice and two Great North Runs, climbed Mount Kilimanjaro and Mont Blanc, completed over 40 solo sky dives with the Royal Air Force, presented a medal at the Commonwealth Games, ran in the 60 metres sprint at the Norwich Union Indoor Athletics
Epigenetics of cocaine addiction kinase for HDAC5. Experiments with mutant proteins and HDAC inhibitors suggested that HDAC5’s action is mediated through its catalytic histone deacetylase domain. Rapid phosphorylation and the export of HDAC5 from the nucleus following cocaine use most likely leads to increased “pulses” of acetylation, targeted gene activation, and behavioral adaptations to long-term cocaine exposure. The second set of experiments that Renthal et al. performed showed that chronic cocaine use induced upregulation of the NK receptor protein in HDAC5 knockout mice, which is associated with hyperacetylation of H3 at the NK1R gene promoter. The NK1R gene promoter has been associated with enhanced