Cocktail umbrella to the fact that the Hawaiian margarita contains tequila instead of rum. Nobody is quite certain exactly when the cocktail umbrella came into use. One possible source is Donn Beach, owner of the Hollywood, California-based restaurant and bar chain Don the Beachcomber. According to cocktail historian Dale DeGroff, Beach started the trend in 1932 after spending much of his time collecting things from around the world, most notably from the South Pacific. Beach sold his merchandise, including the cocktail umbrellas, to Victor Bergeron, owner of the Emeryville, California-based bar chain Trader Vic’s. According to Bergeron’s son Joe, Trader Vic’s used
Cooperstown cocktail Cooperstown cocktail The Cooperstown cocktail refers to a panel of four drug probes used in human pharmacokinetic studies to determine the activity of drug metabolising enzymes. The terminology 'cocktail' refers to the fact that the drug probes are given together. The Cooperstown cocktail consists of four drugs that are considered specific substrates for four cytochrome P450 (CYP) isoforms. One of the drugs (caffeine) provides, through its metabolites, substrates for two additional enzymes (see next paragraph). The drugs and the enzymes they probe are as follows - caffeine (probes CYP1A2, N-acetyltransferase 2, xanthine oxidase), midazolam (probes CYP3A), omeprazole (probes CYP2C19) and