Egon Spengler cluelessness on what the word "epididymis" was. Egon primarily worked with Ray, both of whom were still living at the Firehouse, conducting research on the pink slime. Still very scientifically minded, Egon seems to have loosened up a little bit, letting his sense of humor show and even giving Dana a smile and Peter (who was carried away with photographing Vigo's portrait), a knowing smile. Although the 2016 "Ghostbusters" film is a reboot, the film's marketing confirms that a version of Egon Spengler does exist in the film's fictional universe. According to a tie-in video to the film, Kate McKinnon's
Pictet–Spengler reaction hydrochloric acid forming a tetrahydroisoquinoline. Like the Mannich reaction, aldehydes give good yields while ketones tend to give lower conversion. The Pictet–Spengler reaction has been applied to solid-phase combinatorial chemistry with great success. An analogous reaction with an aryl-β-ethanol is called Oxa-Pictet–Spengler reaction The reaction mechanism occurs by initial formation of an iminium ion (2) followed by electrophilic addition at the 3-position, in accordance with the expected nucleophilicity of indoles, to give the spirocycle 3. After migration of the best migrating group, deprotonation gives the product (5). Replacing an indole with a 3,4-dimethoxyphenyl group give the reaction named the Pictet–Spengler