Units of paper quantity and US measure, in some sources, a quire was originally 24 sheets.) Quires of 15, 18 or 20 sheets have also been used, depending on the type of paper. The current word "quire" derives from OE "quair" or "guaer", from OF "quayer", "cayer", (cf. modern Fr. "cahier"), from L. "quaternum", "by fours", "fourfold". Later, when bookmaking switched to using paper and it became possible to easily stitch 5 to 7 sheets at a time, the association of "quaire" with "four" was quickly lost. In the Middle Ages, a quire (also called a "gathering") was most often formed of 4 folded
First Folio texts were beyond the typesetters' capacity to correct. The Folio was typeset and bound in "sixes" – 3 sheets of paper, taken together, were folded into a booklet-like quire or gathering of 6 leaves, 12 pages. Once printed, the "sixes" were assembled and bound together to make the book. The sheets were printed in 2-page formes, meaning that pages 1 and 12 of the first quire were printed simultaneously on one side of one sheet of paper (which became the "outer" side); then pages 2 and 11 were printed on the other side of the same sheet (the "inner" side).