Egon Spengler Egon Spengler Egon Spengler, PhD is a fictional character from the "Ghostbusters" franchise. He appears in the films "Ghostbusters" and "Ghostbusters II", in the animated television series "The Real Ghostbusters" and "Extreme Ghostbusters", in the video games "" and Beeline's "Ghostbusters". Spengler was portrayed by Harold Ramis in the films and voiced by him in "" and "Lego Dimensions", and voiced by Maurice LaMarche in the cartoon series. He is a member of the Ghostbusters and one of the three doctors of parapsychology, along with Dr. Peter Venkman and Dr. Ray Stantz. The character of Egon Spengler was named after
Pictet–Spengler reaction imine generated from the condensation of the aldehyde and amine. This helps to explain the need for an acidic medium in some substrates, as the imine may not be electrophilic enough for ring closure to occur but the Iminium ion is capable of undergoing the reaction. The Pictet-Spengler reaction is widespread in both human industry and biosynthesis. It has remained an important reaction in the fields of alkaloid and pharmaceutical synthesis since its inception, where it has been employed in the development of many beta-carbolines. The enzyme strictosidine synthase is an example of nature utilizing the Pictet-Spengler reaction, which generates