Egon Spengler Oswald Spengler and a classmate of Ramis at Senn High School, Egon Donsbach, a Hungarian refugee. Christopher Walken, John Lithgow, Christopher Lloyd and Jeff Goldblum were all considered for the role of Egon Spengler, before Ramis, who had gotten close to the character while writing him, felt compelled to play it himself. LaMarche stated that when he auditioned for the part of Spengler in "The Real Ghostbusters", he was asked not to do an impression of Ramis, which he ignored because impressions were one of his strengths as a performer, and there was no other way he could imagine properly
Pictet–Spengler reaction amination. The benzyl group can be removed hydrogenolytically afterwards. As a rough rule, C NMR signals for C1 and C3 are downfield shifted in "cis" products relative to "trans" products (see steric compression effect). Pictet–Spengler reaction The Pictet–Spengler reaction is a chemical reaction in which a β-arylethylamine undergoes condensation with an aldehyde or ketone followed by ring closure. The reaction was first discovered in 1911 by Amé Pictet and Theodor Spengler. Traditionally an acidic catalyst in protic solvent was employed with heating, however the reaction has been shown to work in aprotic media without acid catalysis in superior yields for