Ray Stantz Ray Stantz Raymond "Ray" Stantz, PhD is a fictional character from the "Ghostbusters" franchise. He appears in the films "Ghostbusters" (1984), "Ghostbusters II" (1989), "Casper" (1995, as a cameo), the animated television series "The Real Ghostbusters" and "Extreme Ghostbusters", and the video games Beeline's "Ghostbusters" and "". He was portrayed by Dan Aykroyd in both live action films, and voiced by Frank Welker in the animated series. He is a member of the Ghostbusters and one of the three doctors of parapsychology, along with Dr. Peter Venkman and Dr. Egon Spengler. Dan Aykroyd has a cameo appearance in "Ghostbusters" (2016)
Pictet–Spengler reaction hydrochloric acid forming a tetrahydroisoquinoline. Like the Mannich reaction, aldehydes give good yields while ketones tend to give lower conversion. The Pictet–Spengler reaction has been applied to solid-phase combinatorial chemistry with great success. An analogous reaction with an aryl-β-ethanol is called Oxa-Pictet–Spengler reaction The reaction mechanism occurs by initial formation of an iminium ion (2) followed by electrophilic addition at the 3-position, in accordance with the expected nucleophilicity of indoles, to give the spirocycle 3. After migration of the best migrating group, deprotonation gives the product (5). Replacing an indole with a 3,4-dimethoxyphenyl group give the reaction named the Pictet–Spengler