Egon Spengler It is implied in one episode of the animated series that Spengler accidentally burned down his family's garage. Spengler is the only original Ghostbuster to return for the "Extreme Ghostbusters" series as a regular, acting as a mentor to the new Ghostbusters (the others appeared for a two-part episode, "Back in the Saddle"), and monitoring and sustaining the Containment Unit while working as a paranormal studies professor at a university. He is the de facto leader of the new, younger team of Ghostbusters; although the old team had gone into retirement after they apparently dealt with all the ghosts in
Pictet–Spengler reaction hydrochloric acid forming a tetrahydroisoquinoline. Like the Mannich reaction, aldehydes give good yields while ketones tend to give lower conversion. The Pictet–Spengler reaction has been applied to solid-phase combinatorial chemistry with great success. An analogous reaction with an aryl-β-ethanol is called Oxa-Pictet–Spengler reaction The reaction mechanism occurs by initial formation of an iminium ion (2) followed by electrophilic addition at the 3-position, in accordance with the expected nucleophilicity of indoles, to give the spirocycle 3. After migration of the best migrating group, deprotonation gives the product (5). Replacing an indole with a 3,4-dimethoxyphenyl group give the reaction named the Pictet–Spengler