Nephrology impact on quality and length of life, and so psychological support, health education and advanced care planning play key roles in nephrology. Chronic kidney disease is typically managed with treatment of causative conditions (such as diabetes), avoidance of substances toxic to the kidneys (nephrotoxins like radiologic contrast and non-steroidal anti-inflammatory drugs), antihypertensives, diet and weight modification and planning for end-stage kidney failure. Impaired kidney function has systemic effects on the body. An erythropoetin stimulating agent may be required to ensure adequate production of red blood cells, activated vitamin D supplements and phosphate binders may be required to counteract the effects
The six organs in the Palace of Mafra are common among Iberian instruments of the time. Other features, like the short-resonator reeds, the Italian voce umana, and especially the double-wind chest, (allowing the quick cancellation of the plenum stops) are typical of the school of Cerveira and Fontanes. The six organs in the Palace of Mafra Since their recent restoration, the six organs in the Basilica of the Palace of Mafra have become widely known around the world. The six instruments - designed and built all at the same time, and designed to play together as well - were built by the two most important Portuguese organ builders