Egon Spengler fraud, violating their judicial restraining order, and malicious mischief by judge Stephen Wexler (whom Egon said was known as "The Hammer"). While angrily insulting the trio judge Wexler inadvertently released the ghosts of the Scoleri Brothers; two murderers he sentenced to death by the electric chair. During the chaos judge Wexler dismisses the charges against the Ghostbusters, and rescinds the judicial restraining order allowing Egon, Ray, and Peter to capture the ghosts, effectively putting the Ghostbusters back in business. Egon had a dry sense of humor, of which he used on Peter to bewilder him, and smirked at his friend's
Pictet–Spengler reaction hydrochloric acid forming a tetrahydroisoquinoline. Like the Mannich reaction, aldehydes give good yields while ketones tend to give lower conversion. The Pictet–Spengler reaction has been applied to solid-phase combinatorial chemistry with great success. An analogous reaction with an aryl-β-ethanol is called Oxa-Pictet–Spengler reaction The reaction mechanism occurs by initial formation of an iminium ion (2) followed by electrophilic addition at the 3-position, in accordance with the expected nucleophilicity of indoles, to give the spirocycle 3. After migration of the best migrating group, deprotonation gives the product (5). Replacing an indole with a 3,4-dimethoxyphenyl group give the reaction named the Pictet–Spengler