Egon Spengler Brooklyn; though Spengler managed to thwart the ghost, Melnitz angrily told Spengler he would have to pay for the damages to her home) and when he rushed to her rescue in "Janine, You've Changed"; he also embraces her in "Ghost Busted" after she was kidnapped and held for ransom by a gangster, and became jealous when she was briefly involved with a slimy businessman named Paul Smart. In the episode "Cry Uncle", Spengler's well-meaning but skeptical uncle Cyrus, visits him and, since he does not believe that Spengler's work with the Ghostbusters is real scientific work and therefore a waste
Pictet–Spengler reaction Pictet–Spengler reaction The Pictet–Spengler reaction is a chemical reaction in which a β-arylethylamine undergoes condensation with an aldehyde or ketone followed by ring closure. The reaction was first discovered in 1911 by Amé Pictet and Theodor Spengler. Traditionally an acidic catalyst in protic solvent was employed with heating, however the reaction has been shown to work in aprotic media without acid catalysis in superior yields for a variety of cases. The Pictet–Spengler reaction can be considered a special case of the Mannich reaction, which follows a similar reaction pathway. The driving force for this reaction is the electrophilicity of the