Egon Spengler a room for hours and gradually raising the temperature. A positive test involved a girl in a room with dozens of stuffed animals and a puppy. He was the first person Dana Barrett contacted when her baby carriage took off by itself. Egon recommended bringing in Ray, and they both performed a physical exam on Dana's son Oscar. Egon, along with Peter and Ray were later arrested after digging a large hole under First Avenue as part of their paranormal investigations to help Dana. During the course of their trial they were found guilty of willful destruction of public property,
Pictet–Spengler reaction is created. Several substrate- or auxiliary-controlled diastereoselective Pictet–Spengler reactions have been developed. Additionally, List "et al." have published a chiral Brønsted acid that catalyzes asymmetric Pictet–Spengler reactions. Tryptophans: diastereocontrolled reaction The reaction of enantiopure tryptophan or its short-chain alkylesters leads to 1,2,3,4-tetrahydro-"β"-carbolines in which a new chiral center at C-1 adopts either a "cis" or "trans" configuration towards the C-3 carboxyl group. The "cis" conduction is kinetically controlled, i.e. it is performed at lower temperatures. At higher temperatures the reaction becomes reversible and usually favours racemisation. 1,3-"trans" dominated products can be obtained with "N"-benzylated tryptophans, which are accessible by reductive