Jamie Murray first match at a Grand Slam since Wimbledon 2008 as they progressed to the second round of the Australian Open. Murray followed this up with two semi-final appearances, partnering Alexander Peya at the SA Open and his brother Andy at Rotterdam. These successes saw Murray climb back into the world top 50. At the French Open, Murray and his partner Chris Guccione were eliminated in the second round of the men's doubles by the top-seeded Bryans, but he progressed to the semi-finals of the mixed doubles with Nadia Petrova. In August, he reached the semi-finals of the Winston–Salem Open but
Andy Murray Ranked No. 312, Murray became the first Scot in the Open Era to reach the third round of the men's singles tournament at Wimbledon. In the third round, Murray lost to 2002 Wimbledon finalist David Nalbandian due to cramping and fatigue, having led two sets to love. Following Wimbledon, Murray won Challenger events on the hard courts of Aptos and Binghamton, New York. He then experienced his first Masters event at Cincinnati, where he beat Taylor Dent, before losing in three sets to then-No. 4, Marat Safin. With a wild card entry, Murray played Andrei Pavel in the opening round