Ghostbusters franchise, which includes a 1989 sequel, "Ghostbusters II", two animated television series, "The Real Ghostbusters" and "Extreme Ghostbusters", several video games, and a 2016 reboot film. Peter Venkman, Raymond Stantz, and Egon Spengler are scientists investigating the paranormal at Columbia University. After they lose their jobs following a botched ghost investigation in the University library, they establish Ghostbusters, a paranormal investigation and elimination service. They open their business in a disused firehouse and develop high-tech equipment to capture ghosts. On their first call, at a hotel, Egon warns the group never to cross the energy streams of their proton pack
Pictet–Spengler reaction hydrochloric acid forming a tetrahydroisoquinoline. Like the Mannich reaction, aldehydes give good yields while ketones tend to give lower conversion. The Pictet–Spengler reaction has been applied to solid-phase combinatorial chemistry with great success. An analogous reaction with an aryl-β-ethanol is called Oxa-Pictet–Spengler reaction The reaction mechanism occurs by initial formation of an iminium ion (2) followed by electrophilic addition at the 3-position, in accordance with the expected nucleophilicity of indoles, to give the spirocycle 3. After migration of the best migrating group, deprotonation gives the product (5). Replacing an indole with a 3,4-dimethoxyphenyl group give the reaction named the Pictet–Spengler