Nephrology impact on quality and length of life, and so psychological support, health education and advanced care planning play key roles in nephrology. Chronic kidney disease is typically managed with treatment of causative conditions (such as diabetes), avoidance of substances toxic to the kidneys (nephrotoxins like radiologic contrast and non-steroidal anti-inflammatory drugs), antihypertensives, diet and weight modification and planning for end-stage kidney failure. Impaired kidney function has systemic effects on the body. An erythropoetin stimulating agent may be required to ensure adequate production of red blood cells, activated vitamin D supplements and phosphate binders may be required to counteract the effects
The six organs in the Palace of Mafra as the reassembling of the organ of São Pedro d’Alcântara, were left unfinished. Until 1998, the organs only received minor repairs. That year, the global restoration of the ensemble, entrusted to the Portuguese organ builder Dinarte Machado, began and was concluded in 2010. This project included the reconstruction of the organ of São Pedro d’Alcântara, incorporating all the materials recovered since it was disassembled around 1820. The six organs (two in the main chapel, two in the northern transept, and two in the southern transept), although different, have several common features. Some, like the horizontal reeds and the divided keyboard,