Egon Spengler Venkman hadn't stopped him. Due to the large amount of collateral damage the city of New York suffered from the battle with Gozer, the Ghostbusters were sued by nearly every county and city agency in New York. Additionally a judicial restraining order was enacted which barred the Ghostbusters from performing services as paranormal investigators and eliminators, effectively putting them out of business. Five years after the events of the first film Egon was working at the Institute for Advanced Theoretical Research and was conducting experiments on human emotions. A negative test involved keeping a couple with marriage problems locked in
Pictet–Spengler reaction hydrochloric acid forming a tetrahydroisoquinoline. Like the Mannich reaction, aldehydes give good yields while ketones tend to give lower conversion. The Pictet–Spengler reaction has been applied to solid-phase combinatorial chemistry with great success. An analogous reaction with an aryl-β-ethanol is called Oxa-Pictet–Spengler reaction The reaction mechanism occurs by initial formation of an iminium ion (2) followed by electrophilic addition at the 3-position, in accordance with the expected nucleophilicity of indoles, to give the spirocycle 3. After migration of the best migrating group, deprotonation gives the product (5). Replacing an indole with a 3,4-dimethoxyphenyl group give the reaction named the Pictet–Spengler