Trimethylamine N-oxide Trimethylamine N-oxide Trimethylamine "N"-oxide (TMAO) is an organic compound with the formula (CH)NO. It is in the class of amine oxides. Although the anhydrous compound is known, trimethylamine "N"-oxide is usually encountered as the dihydrate. It is a product of the oxidation of trimethylamine, a common metabolite in animals. Both the anhydrous and hydrated materials are white, water-soluble solids. Trimethylamine "N"-oxide is an osmolyte found in saltwater fishes, sharks, rays, molluscs, and crustaceans. It is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays. It is also higher in deep-sea
Nitrous oxide system, and this may be related to its analgesic and anxiolytic properties. Nitrous oxide is 30-40 times more soluble than nitrogen. The effects of inhaling sub-anaesthetic doses of Nitrous Oxide have been known to vary, based on several factors, including settings and individual differences, however, from his discussion, Jay (2008) suggests that it has been reliably known to induce the following states and sensations: A minority of users also will present with uncontrolled vocalisations and muscular spasms. These effects generally disappear minutes after removal of the nitrous oxide source. In rats, stimulates the mesolimbic reward pathway via inducing dopamine release