Egon Spengler a P.K.E. surge of dangerous proportions. Egon was particularly critical of Walter Peck's actions, and his attitude that the Ghostbusters were responsible for the explosion of the containment unit that occurred when Peck ordered a municipal worker to shut the unit down. After their encounter with Stay Puft, Egon suggested an atypical solution when he recommended blasting Gozer's dimensional portal while crossing the proton streams to reverse the particle flow and send Gozer back to his/its dimension. Egon once tried to drill a hole in his own head (a process known as trepanning), which he says "would have worked" if
Pictet–Spengler reaction imine generated from the condensation of the aldehyde and amine. This helps to explain the need for an acidic medium in some substrates, as the imine may not be electrophilic enough for ring closure to occur but the Iminium ion is capable of undergoing the reaction. The Pictet-Spengler reaction is widespread in both human industry and biosynthesis. It has remained an important reaction in the fields of alkaloid and pharmaceutical synthesis since its inception, where it has been employed in the development of many beta-carbolines. The enzyme strictosidine synthase is an example of nature utilizing the Pictet-Spengler reaction, which generates