Simon Thomas (presenter) 2:1 BA Hons degree in history. Having applied for the job three times, Thomas began presenting the children's programme "Blue Peter" on 8 January 1999 replacing the sacked presenter Richard Bacon. Previously he had worked as a runner at Children's BBC and the radio station LBC. During his tenure at "Blue Peter", he ran in the London Marathon twice and two Great North Runs, climbed Mount Kilimanjaro and Mont Blanc, completed over 40 solo sky dives with the Royal Air Force, presented a medal at the Commonwealth Games, ran in the 60 metres sprint at the Norwich Union Indoor Athletics
Epigenetics of cocaine addiction to be induced by chronic cocaine administration (which had been true in the nucleus accumbens) but acute cocaine reduced expression in the caudate putamen whereas chronic cocaine injections decreased expression even in the NAc in D1 receptor mutants. This pathway influences Wrch1, so it can also influence cocaine-induced neuroadaptations. Lastly, they found that CaMKII-α was not upregulated as expected, and CD2 was downregulated in D1 receptor mutants after chronic treatment. These results suggest gene expression changes are definitely induced by chronic cocaine exposure via the D1 receptor and most at AP-1 binding sites. Contrary to most studies focusing on the