Egon Spengler exhausting trek up the stairs of 55 Central Park West. While in the alternate dimension of the library, Egon is heard to groan, "Oh no," and when Ray asks if he saw something scary, Egon replies, "Stairs, lots of stairs". Before the "Return to Sedgewick Hotel" mission, Stantz comments that Spengler was once a coroner, to which he replied that he maintains interest in the subject as a hobby. Spengler appears in Beeline's "Ghostbusters" game for iOS alongside his niece, Michelle Ying. The game was released on January 24, 2013. Spengler appears in "Lego Dimensions", with archival audio of Harold
Pictet–Spengler reaction imine generated from the condensation of the aldehyde and amine. This helps to explain the need for an acidic medium in some substrates, as the imine may not be electrophilic enough for ring closure to occur but the Iminium ion is capable of undergoing the reaction. The Pictet-Spengler reaction is widespread in both human industry and biosynthesis. It has remained an important reaction in the fields of alkaloid and pharmaceutical synthesis since its inception, where it has been employed in the development of many beta-carbolines. The enzyme strictosidine synthase is an example of nature utilizing the Pictet-Spengler reaction, which generates