Jamie Murray first match at a Grand Slam since Wimbledon 2008 as they progressed to the second round of the Australian Open. Murray followed this up with two semi-final appearances, partnering Alexander Peya at the SA Open and his brother Andy at Rotterdam. These successes saw Murray climb back into the world top 50. At the French Open, Murray and his partner Chris Guccione were eliminated in the second round of the men's doubles by the top-seeded Bryans, but he progressed to the semi-finals of the mixed doubles with Nadia Petrova. In August, he reached the semi-finals of the Winston–Salem Open but
2008 Wimbledon Championships – Day-by-day summaries caused his retirement in the singles earlier in the day. In the women's doubles competition, French Open mixed doubles champion Victoria Azarenka & partner Shahar Pe'er proceeded to the next round. In the men's singles, Queen's Club champion, 2006 and 2007 Wimbledon runner-up Rafael Nadal scored his first win, securing a second round spot along with Jarkko Nieminen, Nicolas Kiefer, Tommy Robredo, Richard Gasquet, Paul-Henri Mathieu, Radek Štěpánek, Gilles Simon, Nicolás Almagro, Mikhail Youzhny, James Blake, two-time finalist Andy Roddick, and twelfth seed Andy Murray, who overcame 'The Magician' Fabrice Santoro 6–3, 6–4, 7–6(5), in little more than two hours,