Egon Spengler a bronze bust of Harold Ramis as the film's version of Spengler is seen just as Erin Gilbert leaves her office. During the credits of "Ghostbusters", the words "For Harold Ramis" are seen. Spengler's hair was changed from brown in the films (Ramis' natural hair color) to a blond pompadour in the animated series (Spengler wore his hair in a ponytail on "Extreme Ghostbusters"). This was reportedly done due to legal issues concerning character / actor likenesses. Despite his leanings toward science, Spengler has a family history of witchcraft (three ancestors, Zedekiah, Eli and Ezekiel, were wizards), of which he
Pictet–Spengler reaction amination. The benzyl group can be removed hydrogenolytically afterwards. As a rough rule, C NMR signals for C1 and C3 are downfield shifted in "cis" products relative to "trans" products (see steric compression effect). Pictet–Spengler reaction The Pictet–Spengler reaction is a chemical reaction in which a β-arylethylamine undergoes condensation with an aldehyde or ketone followed by ring closure. The reaction was first discovered in 1911 by Amé Pictet and Theodor Spengler. Traditionally an acidic catalyst in protic solvent was employed with heating, however the reaction has been shown to work in aprotic media without acid catalysis in superior yields for