Egon Spengler cluelessness on what the word "epididymis" was. Egon primarily worked with Ray, both of whom were still living at the Firehouse, conducting research on the pink slime. Still very scientifically minded, Egon seems to have loosened up a little bit, letting his sense of humor show and even giving Dana a smile and Peter (who was carried away with photographing Vigo's portrait), a knowing smile. Although the 2016 "Ghostbusters" film is a reboot, the film's marketing confirms that a version of Egon Spengler does exist in the film's fictional universe. According to a tie-in video to the film, Kate McKinnon's
Pictet–Spengler reaction imine generated from the condensation of the aldehyde and amine. This helps to explain the need for an acidic medium in some substrates, as the imine may not be electrophilic enough for ring closure to occur but the Iminium ion is capable of undergoing the reaction. The Pictet-Spengler reaction is widespread in both human industry and biosynthesis. It has remained an important reaction in the fields of alkaloid and pharmaceutical synthesis since its inception, where it has been employed in the development of many beta-carbolines. The enzyme strictosidine synthase is an example of nature utilizing the Pictet-Spengler reaction, which generates