Blue Peter stretch of track which, on 3 July 1938, saw the world speed record for steam locomotives of set by LNER A4 Locomotive no. 4468 "Mallard". In October 1998, Richard Bacon was sacked, following reports in "News of the World" that he had taken cocaine. This incident followed shortly after the show's 40th anniversary, when previous presenters returned for a special programme. Those returning included Leila Williams, Valerie Singleton, John Noakes, Peter Purves, Diane Louise Jordan, Anthea Turner, John Leslie, Tim Vincent, Yvette Fielding, Caron Keating, Mark Curry, Janet Ellis, Peter Duncan, Sarah Greene, Tina Heath, Simon Groome and Christopher Wenner.
Epigenetics of cocaine addiction of cocaine. Conversely, an increase of CREB was shown to decrease the rewarding effects of cocaine. Zhang et al. also used microarrays to identify specific genes induced by chronic cocaine use, which depend on a functional D1 receptor 24 hours after cocaine withdrawal. There were 109 genes identified that were either up or down regulated by 1.2 fold or more in the caudate putamen D1 receptor mutant mice after repeat injections. The expression of these genes was totally normal in mice with functional D1 receptors, suggesting chronic cocaine use had a direct influence on mediating these genes through a functional