Jamie Murray first match at a Grand Slam since Wimbledon 2008 as they progressed to the second round of the Australian Open. Murray followed this up with two semi-final appearances, partnering Alexander Peya at the SA Open and his brother Andy at Rotterdam. These successes saw Murray climb back into the world top 50. At the French Open, Murray and his partner Chris Guccione were eliminated in the second round of the men's doubles by the top-seeded Bryans, but he progressed to the semi-finals of the mixed doubles with Nadia Petrova. In August, he reached the semi-finals of the Winston–Salem Open but
Jamie Murray Championships respectively, but failed to progress beyond the third round of Wimbledon. Murray had a public fall out with brother Andy Murray, criticising him for dropping out of the World Group first round tie against Argentina over fears he could aggravate a knee injury. Jamie played in and lost the doubles match with Ross Hutchins. Great Britain eventually lost 4–1. This was Great Britain's first World Group match since 2003, now facing a relegation play-off with Austria. The Murrays would not speak to each other for two weeks. At the Olympic Games, the two Murrays competed together in the doubles