Egon Spengler exhausting trek up the stairs of 55 Central Park West. While in the alternate dimension of the library, Egon is heard to groan, "Oh no," and when Ray asks if he saw something scary, Egon replies, "Stairs, lots of stairs". Before the "Return to Sedgewick Hotel" mission, Stantz comments that Spengler was once a coroner, to which he replied that he maintains interest in the subject as a hobby. Spengler appears in Beeline's "Ghostbusters" game for iOS alongside his niece, Michelle Ying. The game was released on January 24, 2013. Spengler appears in "Lego Dimensions", with archival audio of Harold
Pictet–Spengler reaction is created. Several substrate- or auxiliary-controlled diastereoselective Pictet–Spengler reactions have been developed. Additionally, List "et al." have published a chiral Brønsted acid that catalyzes asymmetric Pictet–Spengler reactions. Tryptophans: diastereocontrolled reaction The reaction of enantiopure tryptophan or its short-chain alkylesters leads to 1,2,3,4-tetrahydro-"β"-carbolines in which a new chiral center at C-1 adopts either a "cis" or "trans" configuration towards the C-3 carboxyl group. The "cis" conduction is kinetically controlled, i.e. it is performed at lower temperatures. At higher temperatures the reaction becomes reversible and usually favours racemisation. 1,3-"trans" dominated products can be obtained with "N"-benzylated tryptophans, which are accessible by reductive