Egon Spengler Brooklyn; though Spengler managed to thwart the ghost, Melnitz angrily told Spengler he would have to pay for the damages to her home) and when he rushed to her rescue in "Janine, You've Changed"; he also embraces her in "Ghost Busted" after she was kidnapped and held for ransom by a gangster, and became jealous when she was briefly involved with a slimy businessman named Paul Smart. In the episode "Cry Uncle", Spengler's well-meaning but skeptical uncle Cyrus, visits him and, since he does not believe that Spengler's work with the Ghostbusters is real scientific work and therefore a waste
Pictet–Spengler reaction hydrochloric acid forming a tetrahydroisoquinoline. Like the Mannich reaction, aldehydes give good yields while ketones tend to give lower conversion. The Pictet–Spengler reaction has been applied to solid-phase combinatorial chemistry with great success. An analogous reaction with an aryl-β-ethanol is called Oxa-Pictet–Spengler reaction The reaction mechanism occurs by initial formation of an iminium ion (2) followed by electrophilic addition at the 3-position, in accordance with the expected nucleophilicity of indoles, to give the spirocycle 3. After migration of the best migrating group, deprotonation gives the product (5). Replacing an indole with a 3,4-dimethoxyphenyl group give the reaction named the Pictet–Spengler