Andy Murray the victory to former player Elena Baltacha. He then lost to qualifier Santiago Giraldo in the following round. Murray then reached the quarter-finals of the Rome Masters where he lost to No. 1 Rafael Nadal in a tight match in which he had been up a break in the final set. At the French Open, Murray defeated Andrey Golubev and Marinko Matosevic before edging out 28th seed Philipp Kohlschreiber 12–10 in the final set. This was the first time Murray had ever gone beyond 7–5 in a deciding set. He followed this up with a straight sets win over Fernando
Andy Roddick fourth round, before being upset by unseeded and eventual finalist, Marcos Baghdatis. At the French Open, Roddick retired in the first round, after sustaining a foot injury during the match. Two weeks later at Wimbledon, Roddick was upset in the third round by British hopeful Andy Murray. This loss caused Roddick to fall below the top 10 for the first time since 2002. After Wimbledon, Roddick began working with a new coach, tennis legend Jimmy Connors. In his first event with his new coach, Roddick reached the final of Indianapolis, before losing to good friend and fellow American, James Blake.