Egon Spengler a room for hours and gradually raising the temperature. A positive test involved a girl in a room with dozens of stuffed animals and a puppy. He was the first person Dana Barrett contacted when her baby carriage took off by itself. Egon recommended bringing in Ray, and they both performed a physical exam on Dana's son Oscar. Egon, along with Peter and Ray were later arrested after digging a large hole under First Avenue as part of their paranormal investigations to help Dana. During the course of their trial they were found guilty of willful destruction of public property,
Pictet–Spengler reaction imine generated from the condensation of the aldehyde and amine. This helps to explain the need for an acidic medium in some substrates, as the imine may not be electrophilic enough for ring closure to occur but the Iminium ion is capable of undergoing the reaction. The Pictet-Spengler reaction is widespread in both human industry and biosynthesis. It has remained an important reaction in the fields of alkaloid and pharmaceutical synthesis since its inception, where it has been employed in the development of many beta-carbolines. The enzyme strictosidine synthase is an example of nature utilizing the Pictet-Spengler reaction, which generates