Lorraine Heggessey involved in the dismissal of "Blue Peter" presenter Richard Bacon. In October 1998, the "News of the World" newspaper revealed that Bacon had taken cocaine, and he was subsequently sacked from his job as a presenter on the high-profile children's programme. Heggessey appeared on-screen in a specially-recorded one-minute address to viewers shown directly before the first episode of "Blue Peter" to be screened following Bacon's sacking, on 19 October 1998, to explain to young viewers why Bacon had been dismissed, claiming that he had "not only let himself and the team on "Blue Peter" down, but he has also let
Cocaine intoxication hours after use. Epicardial coronary arteries are especially vulnerable to these effects, leading to decreased myocardial oxygen supply. Cocaine-induced platelet activation and thrombus formation is another deleterious effect, caused by alpha-adrenergic- and adenosine diphosphate-mediated increase in platelet aggregation. Plasminogen activator inhibitor is also increased following cocaine use, thereby promoting thrombosis. Similar to local anesthetics such as lidocaine, cocaine blocks sodium channels and interferes with action potential propagation. This Vaughn-Williams class IC effect increases the risk of conduction disturbance and tachyarrhythmias. Adding to its complex toxicity, cocaine targets muscarinic acetylcholine, N-methyl-D-aspartate (NMDA), sigma, and kappa-opioid receptors. Emergency treatment of cocaine-associated hyperthermia