Egon Spengler portraying the character other than to follow Ramis's example. He got the part anyway and said in an interview that he did two different takes: in which he impersonated Ramis, the other in which he tried a more "Woody Allen"-like approach that did not suit the character's physicality, he admitted. Egon Spengler is a tall, laconic, bespectacled, awkward member of the team responsible for the main theoretical framework for their paranormal/quantum studies. Being addicted to science, he is the creator of the Ghostbusters' equipment along with Raymond Stantz, thus making him the brains of the Ghostbusters. Although book smart, Spengler
Pictet–Spengler reaction tetrahydroisoquinoline synthesis. Reaction conditions are generally harsher than the indole variant, and require refluxing conditions with strong acids like hydrochloric acid, trifluoroacetic acid or superacids. Instead of catalyzing the Pictet-Spengler cyclization with strong acid, one can acylate the iminium ion forming the intermediate "N"-acyliminium ion. The "N"-acyliminium ion is a very powerful electrophile and most aromatic ring systems will cyclize under mild conditions with good yields. Tadalafil is synthesized via the "N"-acyliminium Pictet–Spengler reaction. This reaction can also be catalyzed by AuCl and AgOTf. When the Pictet–Spengler reaction is performed with an aldehyde other than formaldehyde, a new chiral center