Trimethylamine N-oxide Trimethylamine N-oxide Trimethylamine "N"-oxide (TMAO) is an organic compound with the formula (CH)NO. It is in the class of amine oxides. Although the anhydrous compound is known, trimethylamine "N"-oxide is usually encountered as the dihydrate. It is a product of the oxidation of trimethylamine, a common metabolite in animals. Both the anhydrous and hydrated materials are white, water-soluble solids. Trimethylamine "N"-oxide is an osmolyte found in saltwater fishes, sharks, rays, molluscs, and crustaceans. It is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays. It is also higher in deep-sea
Worse is better in comparison with "The Right Thing". However he also states that "it has better survival characteristics than the-right-thing" development style and is superior to the "MIT Approach" with which he contrasted it in the original essay. Gabriel was a Lisp programmer when he formulated the concept in 1989, presenting it in his essay "Lisp: Good News, Bad News, How to Win Big". A section of the article, titled "The Rise of 'Worse is Better'", was widely disseminated beginning in 1991, after Jamie Zawinski found it in Gabriel's files at Lucid Inc. and e-mailed it to friends and colleagues. In "The