Blue Peter stretch of track which, on 3 July 1938, saw the world speed record for steam locomotives of set by LNER A4 Locomotive no. 4468 "Mallard". In October 1998, Richard Bacon was sacked, following reports in "News of the World" that he had taken cocaine. This incident followed shortly after the show's 40th anniversary, when previous presenters returned for a special programme. Those returning included Leila Williams, Valerie Singleton, John Noakes, Peter Purves, Diane Louise Jordan, Anthea Turner, John Leslie, Tim Vincent, Yvette Fielding, Caron Keating, Mark Curry, Janet Ellis, Peter Duncan, Sarah Greene, Tina Heath, Simon Groome and Christopher Wenner.
Cocaine intoxication hours after use. Epicardial coronary arteries are especially vulnerable to these effects, leading to decreased myocardial oxygen supply. Cocaine-induced platelet activation and thrombus formation is another deleterious effect, caused by alpha-adrenergic- and adenosine diphosphate-mediated increase in platelet aggregation. Plasminogen activator inhibitor is also increased following cocaine use, thereby promoting thrombosis. Similar to local anesthetics such as lidocaine, cocaine blocks sodium channels and interferes with action potential propagation. This Vaughn-Williams class IC effect increases the risk of conduction disturbance and tachyarrhythmias. Adding to its complex toxicity, cocaine targets muscarinic acetylcholine, N-methyl-D-aspartate (NMDA), sigma, and kappa-opioid receptors. Emergency treatment of cocaine-associated hyperthermia