Study of Health in Pomerania Pomeranian adult population. In the Northeast of Germany nearly 50% - 60% indicate these diseases. SHIP is the first population based cohort study worldwide which includes whole-body MRI. The aims of the following main whole body-MRI study are: (1)To provide prevalence estimates for different MR findings in a general adult population. (2)To establish population-based MRI reference parameters for various organs and organ parts such as left and right ventricular size or volume of liver, spleen, kidney, prostate, and brain structures . Clinical MR reference parameters currently in use were derived from small, nonrepresentative samples and are thus prone to selection
Circumventricular organs an integral part of neuroendocrine function. The highly permeable capillaries allow the CVOs to act as an alternative route for peptides and hormones in the neural tissue to sample from and secrete to circulating blood. CVOs also have roles in body fluid regulation, cardiovascular functions, immune responses, thirst, feeding behavior and reproductive behavior. CVOs can be classified as either sensory or secretory organs serving homeostatic functions and body water balance. The sensory organs include the area postrema (AP), the subfornical organ (SFO) and the vascular organ of lamina terminalis, all having the ability to sense signals in blood, then pass