Egon Spengler does not have much social ability, as demonstrated by his stiff interactions with the Ghostbusters' secretary Janine Melnitz, and his reliance on Peter Venkman as spokesperson for the group. Spengler is the most serious and rigid member of the team. Of his hobbies, Spengler states that he collects "spores, molds, and fungus", and claims that, as a child, the only toy he ever had was "part of a Slinky", which he straightened out. As implied in the first movie, Spengler apparently is a sugar junkie, due to his affection for sweets and candy. According to the 2009 video game, Spengler
Pictet–Spengler reaction tetrahydroisoquinoline synthesis. Reaction conditions are generally harsher than the indole variant, and require refluxing conditions with strong acids like hydrochloric acid, trifluoroacetic acid or superacids. Instead of catalyzing the Pictet-Spengler cyclization with strong acid, one can acylate the iminium ion forming the intermediate "N"-acyliminium ion. The "N"-acyliminium ion is a very powerful electrophile and most aromatic ring systems will cyclize under mild conditions with good yields. Tadalafil is synthesized via the "N"-acyliminium Pictet–Spengler reaction. This reaction can also be catalyzed by AuCl and AgOTf. When the Pictet–Spengler reaction is performed with an aldehyde other than formaldehyde, a new chiral center