Classes of metals Classes of metals Class A metals are metals that form hard acids. Hard acids are acids with relatively ionic bonds. These metals, such as iron, aluminium, titanium, sodium, calcium and the lanthanides, would rather bond with fluorine than iodine. They form stable products with hard bases, which are bases with ionic bonds. They target molecules such as phospholipids, nucleic acids and ATP. Class B metals are metals that form soft acids. Soft acids are acids with relatively covalent bonds. These metals, such as lead, gold, palladium, platinum, mercury and rhodium, would rather bond with iodine than fluorine. They form stable
Heavy metals completely settled. In biochemistry, heavy metals are sometimes defined—on the basis of the Lewis acid (electronic pair acceptor) behaviour of their ions in aqueous solution—as class B and borderline metals. In this scheme, class A metal ions prefer oxygen donors; class B ions prefer nitrogen or sulfur donors; and borderline or ambivalent ions show either class A or B characteristics, depending on the circumstances. Class A metals, which tend to have low electronegativity and form bonds with large ionic character, are the alkali and alkaline earths, aluminium, the group 3 metals, and the lanthanides and actinides. Class B metals, which