Egon Spengler is not so much ashamed as "strongly" considers irrelevant, mainly because he sees science as relevant. Spengler's faith in science was also tested in one episode where the Ghostbusters get abducted to the ghost world by the ghost of Al Capone. Spengler's scientific equipment fails until he is told by former capos of Capone (who aid the Ghostbusters in revenge for Capone double-crossing them) that only magic can harm ghosts in the ghost world as opposed to science harming ghosts in the human world, thus forcing Spengler to accept the wizardry methods of his ancestors to defeat Capone. He is
Pictet–Spengler reaction imine generated from the condensation of the aldehyde and amine. This helps to explain the need for an acidic medium in some substrates, as the imine may not be electrophilic enough for ring closure to occur but the Iminium ion is capable of undergoing the reaction. The Pictet-Spengler reaction is widespread in both human industry and biosynthesis. It has remained an important reaction in the fields of alkaloid and pharmaceutical synthesis since its inception, where it has been employed in the development of many beta-carbolines. The enzyme strictosidine synthase is an example of nature utilizing the Pictet-Spengler reaction, which generates