Harold Ramis Dan Aykroyd on the screenplay for "Ghostbusters", which became one of the biggest comedy hits of all time, in which he also starred as Dr. Egon Spengler, a role he reprised for the 1989 sequel, "Ghostbusters II" (which he also co-wrote with Aykroyd). His later film "Groundhog Day" has been called his "masterpiece". His films have been noted for attacking "the smugness of institutional life ... with an impish good [will] that is unmistakably American". They are also noted for "Ramis's signature tongue-in-cheek pep talks". Sloppiness and improv were also important aspects of his work. Ramis frequently depicted the qualities
Pictet–Spengler reaction amination. The benzyl group can be removed hydrogenolytically afterwards. As a rough rule, C NMR signals for C1 and C3 are downfield shifted in "cis" products relative to "trans" products (see steric compression effect). Pictet–Spengler reaction The Pictet–Spengler reaction is a chemical reaction in which a β-arylethylamine undergoes condensation with an aldehyde or ketone followed by ring closure. The reaction was first discovered in 1911 by Amé Pictet and Theodor Spengler. Traditionally an acidic catalyst in protic solvent was employed with heating, however the reaction has been shown to work in aprotic media without acid catalysis in superior yields for