Trimethylamine N-oxide Trimethylamine N-oxide Trimethylamine "N"-oxide (TMAO) is an organic compound with the formula (CH)NO. It is in the class of amine oxides. Although the anhydrous compound is known, trimethylamine "N"-oxide is usually encountered as the dihydrate. It is a product of the oxidation of trimethylamine, a common metabolite in animals. Both the anhydrous and hydrated materials are white, water-soluble solids. Trimethylamine "N"-oxide is an osmolyte found in saltwater fishes, sharks, rays, molluscs, and crustaceans. It is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays. It is also higher in deep-sea
Worse is better third will be improved to a point that is almost the right thing. In concrete terms, even though Lisp compilers in 1987 were about as good as C compilers, there are many more compiler experts who want to make C compilers better than want to make Lisp compilers better." Gabriel credits Jamie Zawinski for excerpting the worse-is-better sections of "Lisp: Good News, Bad News, How to Win Big" and e-mailing them to his friends at Carnegie Mellon University, who sent them to their friends at Bell Labs, "who sent them to their friends everywhere". He apparently connected these ideas to