The General in His Labyrinth explores the labyrinth of Bolívar's life through the narrative of his memories, in which "despair, sickness, and death inevitably win out over love, health, and life". Following the success of "One Hundred Years of Solitude" and "Love in the Time of Cholera", García Márquez decided to write about the "Great Liberator" after reading an unfinished novel by his friend Álvaro Mutis. He borrowed the setting—Bolívar's voyage down the Magdalena River in 1830—from Mutis. García Márquez spent two years researching the subject, encompassing the extensive memoirs of Bolívar's Irish aide-de-camp, Daniel Florencio O'Leary, as well as numerous other historical documents and
Love in the Time of Cholera the specific, personal choice that Fermina faces through her life. Florentino's passionate pursuit of nearly countless women stands in contrast to Urbino's clinical discussion of male anatomy on their wedding night. Urbino's eradication of cholera in the town takes on the additional symbolic meaning of ridding Fermina's life of rage, but also passion. It is this second meaning to the title that manifests itself in Florentino's hatred for Urbino's marriage to Fermina, as well as in the social strife and warfare that serves as a backdrop to the entire story. Jeremiah Saint-Amour's death inspires Urbino to meditate on his own