Yellowstone Park bison herd a highly contagious zoonosis caused by ingestion of unpasteurized milk or undercooked meat from infected animals, or close contact with their secretions. Brucellosis occurs naturally in the Yellowstone Bison Herd and the normal winter migrations of bison outside the park have raised concerns that Brucellosis infected Bison may infect cattle. The United States government has programs to eradicate brucellosis in domestic livestock. Since 1934, an estimated $3.5 billion in federal, state, and private funds has been spent on brucellosis eradication in domestic livestock. Over the years, the National Park Service and states bordering the park have implemented various plans to
Swine brucellosis nickel transport, "nikA", is activated by metal ion deficiency and is expressed once in the phagosome. Nickel is essential for many enzymatic reactions, including ureolysis to produce ammonia which in turn may neutralize acidic pH. Since "B. suis" is unable to grow in a strongly acidic medium, it could be protected from acidification by the ammonia. Summary: The most frequent clinical sign following "B. suis" infection is abortion in pregnant females, reduced milk production, and infertility. Cattle can also be transiently infected when they share pasture or facilities with infected pigs, and "B. suis" can be transmitted by cow’s milk.