Take That Take That Take That are an English pop group formed in Manchester in 1990. The group currently consists of Gary Barlow, Howard Donald and Mark Owen. The original line-up also featured Jason Orange and Robbie Williams. Barlow acts as the group's lead singer and primary songwriter, with Owen and Williams initially providing backing vocals and Donald and Orange serving primarily as dancers. The group have had 28 top 40 singles and 17 top 5 singles in the United Kingdom, 12 of which have reached number one, as well as having seven number one albums. Internationally, the band have had 56
Family with sequence similarity 111 member a Family with sequence similarity 111 member a Family with sequence similarity 111 member A is a protein that in humans is encoded by the FAM111A gene. The protein encoded by this gene is cell-cycle regulated, and has nuclear localization. The C-terminal half of the protein shares homology with trypsin-like peptidases and it contains a PCNA-interacting peptide (PIP) box, that is necessary for its co-localization with proliferating cell nuclear antigen (PCNA). Reduced expression of this gene resulted in DNA replication defects, consistent with the demonstrated role for this gene in Simian Virus 40 (SV40) viral replication. Mutations in this gene have