The General in His Labyrinth explores the labyrinth of Bolívar's life through the narrative of his memories, in which "despair, sickness, and death inevitably win out over love, health, and life". Following the success of "One Hundred Years of Solitude" and "Love in the Time of Cholera", García Márquez decided to write about the "Great Liberator" after reading an unfinished novel by his friend Álvaro Mutis. He borrowed the setting—Bolívar's voyage down the Magdalena River in 1830—from Mutis. García Márquez spent two years researching the subject, encompassing the extensive memoirs of Bolívar's Irish aide-de-camp, Daniel Florencio O'Leary, as well as numerous other historical documents and
Love in the Time of Cholera (film) later, Fermina agrees to marry Dr. Juvenal Urbino, her father's choice. Their 50-year marriage is outwardly loving but inwardly marred by darker emotions. Fermina's marriage devastates Florentino, who vows to remain a virgin, but his self-denial is thwarted by a tryst. To help him get over Fermina, his mother throws a willing widow into his bed, and he discovers that sex is a very good pain reliever, one he uses to replace the opium that he had habitually smoked. He begins to record and describe each of his sexual encounters, beginning with the widow, and eventually compiles over 600 entries.