United States raw milk debate prior to symptom onset." Milk collected or stored in unsanitary conditions may harbor a host of disease-causing organisms (pathogens), such as "tuberculosis" (Mycobacterium bovis), the bacteria "Campylobacter" (Campylobacteriosis), "Escherichia" E. coli O157:H7), "Listeria" (Listeriosis), "Salmonella" (Salmonellosis), "Yersinia" (Yersinia enterocolitica), and "Brucella" (Brucellosis). Pasteurization consistently removes all of these pathogens, though they can be reintroduced if the product is handled carelessly. Thus dairy farms that pasteurize their milk can have unsanitary facilities without the attendant outbreaks of disease that would occur if a raw milk dairy kept its herds in similar unsanitary conditions. People with weakened immune systems, such as elderly,
Swine brucellosis nickel transport, "nikA", is activated by metal ion deficiency and is expressed once in the phagosome. Nickel is essential for many enzymatic reactions, including ureolysis to produce ammonia which in turn may neutralize acidic pH. Since "B. suis" is unable to grow in a strongly acidic medium, it could be protected from acidification by the ammonia. Summary: The most frequent clinical sign following "B. suis" infection is abortion in pregnant females, reduced milk production, and infertility. Cattle can also be transiently infected when they share pasture or facilities with infected pigs, and "B. suis" can be transmitted by cow’s milk.