United States raw milk debate systematic review of the food safety of unpasteurized milk concluded that science-based data to substantiate claims of health benefits "are lacking or do not exist" and the risks associated with disease outbreaks as a result of raw milk consumption are "considerably higher". Pasteurization was first used in the United States in the 1890s after the discovery of germ theory to control the hazards of highly contagious bacterial diseases, including bovine tuberculosis and brucellosis, that could be easily transmitted to humans through the drinking of raw milk. Initially after the scientific discovery of bacteria, no product testing was available to determine
Brucellosis least six weeks. This regimen has the advantage of oral administration. A triple therapy of doxycycline, with rifampin and co-trimoxazole, has been used successfully to treat neurobrucellosis. Doxycycline is able to cross the blood–brain barrier, but requires the addition of two other drugs to prevent relapse. Ciprofloxacin and co-trimoxazole therapy is associated with an unacceptably high rate of relapse. In brucellic endocarditis, surgery is required for an optimal outcome. Even with optimal antibrucellic therapy, relapses still occur in 5 to 10% of patients with Malta fever. The main way of preventing brucellosis is by using fastidious hygiene in producing raw