Alice Catherine Evans service worker was protected by law. Alice became interested in the disease brucellosis and its relationship to fresh, unpasteurized milk. Alice's investigation focused on the organism "Bacillus abortus", known to cause miscarriages in animals. Alice learned that the microbe thrived in infected cows as well as animals that appeared healthy. The reports hypothesized that since the bacteria was found in cow's milk, a threat to human health was likely. Evans decided to investigate this; she wondered whether the disease in cows could be the cause of undulant fever in humans. She reported her findings to the Society of American Bacteriologists
Swine brucellosis nickel transport, "nikA", is activated by metal ion deficiency and is expressed once in the phagosome. Nickel is essential for many enzymatic reactions, including ureolysis to produce ammonia which in turn may neutralize acidic pH. Since "B. suis" is unable to grow in a strongly acidic medium, it could be protected from acidification by the ammonia. Summary: The most frequent clinical sign following "B. suis" infection is abortion in pregnant females, reduced milk production, and infertility. Cattle can also be transiently infected when they share pasture or facilities with infected pigs, and "B. suis" can be transmitted by cow’s milk.