Santa's Little Helper realistic dilemma faced by many families who own dogs. Other episode ideas come from popular culture. For example, Santa's Little Helper fathering 25 puppies in "Two Dozen and One Greyhounds" is a parody of the Disney film "One Hundred and One Dalmatians", and Mr. Burns' technique of brainwashing him into an attack dog in "Dog of Death" parodies "A Clockwork Orange". Susan McHugh, who teaches theories of animals, literature, and culture at the University of New England, wrote in her 2004 book "Dog" that, "remaining loyal to his unlikely saviours, the boy Bart and his father Homer, this greyhound has
T helper cell because such knowledge may be very useful in the treatment of disease and in increasing the effectiveness of vaccination. Proliferating helper T cells that develop into effector T cells differentiate into two major subtypes of cells known as T1 and T2 cells (also known as Type 1 and Type 2 helper T cells, respectively). T1 helper cells lead to an increased cell-mediated response, typically against intracellular bacteria and protozoa. They are triggered by IL-12 and their effector cytokines are IFN-γ and IL-2. The main effector cells of T1 immunity are macrophages as well as CD8 T cells, IgG B cells,