Ze339 Ze339 Ze339 brand herbal extracts are taken from the leaves of a unique variety (Petzell) of the butterbur ("Petasites hybridus") plant. Petzell is grown on GAP-managed farms in Europe. In Switzerland, South Korea and Brazil, tablets containing Ze339 brand herbal extracts are marketed under the brand name Tesalin. Ze339 is marketed in the US as Zarbee's Naturals Seasonal Relief. Ze339 is indicated for seasonal allergic rhinitis (hay fever). The ingredient has been evaluated in placebo-controlled, double-blind clinical studies. Ze339 was shown to be as effective as the antihistamines cetirizine and fexofenadine. Against desloratadine, an improved version of loratadine, Ze339 had
Rhinitis medicamentosa Rhinitis medicamentosa Rhinitis medicamentosa (or RM) is a condition of rebound nasal congestion brought on by extended use of topical decongestants (e.g., oxymetazoline, phenylephrine, xylometazoline, and naphazoline nasal sprays) and certain oral medications (e.g., sympathomimetic amines and various 2-imidazolines) that constrict blood vessels in the lining of the nose. The characteristic presentation of RM involves nasal congestion without rhinorrhea, postnasal drip, or sneezing following several days of decongestant use. This condition typically occurs after 5–7 days of use of topical decongestants. Patients often try increasing both the dose and the frequency of nasal sprays upon the onset of RM, worsening