Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
Valentine's Day on January 25 instead of (or as well as) Valentine's Day. The day commemorates St Dwynwen, the Welsh patron saint of love. The Welsh name for Saint Valentine is 'Sant Ffolant'. On Saint Valentine's Day in Ireland, many individuals who seek true love make a Christian pilgrimage to the Shrine of St. Valentine in Whitefriar Street Carmelite Church in Dublin, which is said to house relics of Saint Valentine of Rome; they pray at the shrine in hope of finding romance. There lies a book in which foreigners and locals have written their prayer requests for love. In Finland Valentine's