Santa's Little Helper real-life breed will paint a different picture — of dogs that are peaceful, affectionate, [and] not given to drooling, panting". Some ideas for episodes featuring Santa's Little Helper come from reality. The plot of "Dog of Death" was based on Swartzwelder's experiences with his own dog, which had also suffered from bloat. However, unlike the events in the episode, Swartzwelder's dog did not receive treatment as the operation was too expensive and the dog was too old. "The Gold Coast Bulletin"s Ryan Ellem commented in 2005 that the Simpson family's dilemma with the cost of the veterinary procedure is a
Brother's Little Helper by director Mark Kirkland and was the first episode staff writer George Meyer received a sole writing credit for since the season 5 episode "Bart's Inner Child". Meyer, who was facing some psychological difficulties while writing the episode, felt so dissatisfied with the episode's first draft that he turned it in with a pseudonym. The episode satirizes the perceived misdiagnosis of behavioral disorders in children, which was a controversial topic at the time the episode was written. The episode's title is a parody of The Rolling Stones song "Mother's Little Helper", which was also written on the topic of psychological