Penicillin nontoxic in humans by first performing toxicity tests in animals and then on humans. His subsequent experiments on penicillin's response to heat and pH allowed Fleming to increase the stability of the compound. The one test that modern scientists would find missing from his work was the test of penicillin on an infected animal, the results of which would likely have sparked great interest in penicillin and sped its development by almost a decade. The importance of his work has been recognized by the placement of an International Historic Chemical Landmark at the Alexander Fleming Laboratory Museum in London on
The Valentine his collection of art and artifacts, the 1812 John Wickham House and a $50,000 endowment. Their collection of art and artifacts was the foundation of the exhibitions, when the Valentine Museum opened in 1898. Part of the original intent of the founding of the museum was to display these archeological artifacts in perpetuity, after the family was embarrassed by an archeological hoax in North Carolina. When it opened, the Valentine Museum was the first private museum in the City of Richmond Mann S. Valentine II's brother Edward Virginius Valentine also had an interest in history and was a well-known sculptor.