Santa's Little Helper the dog was a "sympathetic" character. Welker has been praised by staff members for his performances on the show. David Mirkin has noted that "he can do anything, and it fits perfectly. You forget you're listening to a guy, and he's a pleasure to work with." Groening has commented that he was "unbelievably good" at doing animal noises. After 1995, Castellaneta voiced Santa's Little Helper on his own while Welker performed other animal noises until his full departure in 2002, when he was denied a pay raise. In the "questions and answers" section on his website, Welker revealed that the
T helper 3 cell T helper 3 cell T helper 3 cells (T3) are white blood cells of the lymphocyte type. They are involved in regulating the body's immune response. The function of T helper cells generally is to mediate the immune response by secreting cytokines and interacting with B-cells to enhance or inhibit their activity. This is of particular importance in the gut as this is where the highest load of foreign material, food, is present. T3 cells are involved in mucosal immunity and protecting mucosal surfaces in the gut from non-pathogenic non-self antigens. They mediate this non-inflammatory environment by secreting TGF-β and