Santa's Little Helper of whom, admittedly, have strong speech impediments, he doesn’t talk or wisecrack or engage in shenanigans. His abilities and powers begin and end with masticating, defecating, and regular napping. You know, just like a real dog. Consequently, episodes devoted to Santa’s Little Helper tend to be a little on the sleepy side, even the "Simpsons" Christmas special that launched the series." Since his first appearance on "The Simpsons", Santa's Little Helper has appeared in merchandise relating to the show. On the board art of "The Simpsons Clue", a 2000 board game by USAopoly based on "Clue", he is shown drinking
T helper cell because such knowledge may be very useful in the treatment of disease and in increasing the effectiveness of vaccination. Proliferating helper T cells that develop into effector T cells differentiate into two major subtypes of cells known as T1 and T2 cells (also known as Type 1 and Type 2 helper T cells, respectively). T1 helper cells lead to an increased cell-mediated response, typically against intracellular bacteria and protozoa. They are triggered by IL-12 and their effector cytokines are IFN-γ and IL-2. The main effector cells of T1 immunity are macrophages as well as CD8 T cells, IgG B cells,