Ze339 Ze339 Ze339 brand herbal extracts are taken from the leaves of a unique variety (Petzell) of the butterbur ("Petasites hybridus") plant. Petzell is grown on GAP-managed farms in Europe. In Switzerland, South Korea and Brazil, tablets containing Ze339 brand herbal extracts are marketed under the brand name Tesalin. Ze339 is marketed in the US as Zarbee's Naturals Seasonal Relief. Ze339 is indicated for seasonal allergic rhinitis (hay fever). The ingredient has been evaluated in placebo-controlled, double-blind clinical studies. Ze339 was shown to be as effective as the antihistamines cetirizine and fexofenadine. Against desloratadine, an improved version of loratadine, Ze339 had
Allergic rhinitis of prolonged steroid therapy. Other measures that may be used second line include: decongestants, cromolyn, leukotriene receptor antagonists, and nonpharmacologic therapies such as nasal irrigation. Topical decongestants may also be helpful in reducing symptoms such as nasal congestion, but should not be used for long periods, as stopping them after protracted use can lead to a rebound nasal congestion called rhinitis medicamentosa. For nocturnal symptoms, intranasal corticosteroids can be combined with nightly oxymetazoline, an adrenergic alpha-agonist, or an antihistamine nasal spray without risk of rhinitis medicamentosa. Nasal saline irrigation (a practice where salt water is poured into the nostrils), may