HEK 293 cells cell, all of which are abundant in kidneys. However, the original adenovirus transformation was inefficient, suggesting that the cell that finally produced the HEK 293 line may have been unusual in some fashion. Graham and coworkers provided evidence that HEK 293 cells and other human cell lines generated by adenovirus transformation of human embryonic kidney cells have many properties of immature neurons, suggesting that the adenovirus preferentially transformed a neuronal lineage cell in the original kidney culture. A comprehensive study of the genomes and transcriptomes of HEK 293 and five derivative cell lines compared the HEK 293 transcriptome with that
Over There (Fringe) traveling to the Other Side. The show had been developing a parallel universe storyline since its conception, but "Over There" marked the longest time spent in that world thus far. Pinker explained the idea of two worlds: "One of the big themes of the show is how small choices that you make define you as a person and can change your life in large ways down the line." Wyman said that the parallel universe "is a reminder to our viewers that your life is what your choices are." The two began discussing details about the Other Side early on, especially