Malus sieversii modern apple cultivars. Unlike domesticated varieties its leaves go red in autumn: 62.2% of the trees in the wild do this compared to only 2.8% of the regular apple plant or the 2,170 English cultivated varieties. The species is now considered vulnerable to extinction. "Malus sieversii" has previously been identified as the main contributor to the genome of the cultivated apple ("Malus pumila"), on the basis of morphological, molecular, and historical evidence. A DNA analysis in 2010 confirmed "M. sieversii" as the progenitor of the cultivated apple. A third species that has been thought to have made contributions to the
Karl Malus who runs IGH, a biotech clinic that specializes in state-of-the-art reconstructive surgery. When Jessica Jones and her mother Alisa are critically injured in a car accident, Dr. Malus arranges for them to be siphoned from Metro-General Hospital to his clinic so he can save their lives. Jessica gets released after about three weeks, while Alisa's recovery takes several more years due to more extensive damage. Over the course of treating her, Dr. Malus develops romantic feelings for Alisa, and even covers up her accidental killing of one of his nurses by having a janitor take the fall for the crime.