Santa's Little Helper and Maggie are—heck, most Americans probably recognize their pets, Santa's Little Helper and Snowball II". McHugh wrote in "Dog" that while Master McGrath was the most famous greyhound of the 19th century, "the most popular greyhound a hundred years later" is Santa's Little Helper. In the television special "50 Greatest TV Animals" that was hosted by Mario Lopez and aired on Animal Planet in 2003, the dog ranked 27th. Other dogs featured on the list were Lassie (first), Eddie (fifth), Snoopy (sixth), Scooby-Doo (13th), Rin Tin Tin (14th), Max (20th), Triumph, the Insult Comic Dog (24th), Buck (29th), Chipper (44th),
T helper cell because such knowledge may be very useful in the treatment of disease and in increasing the effectiveness of vaccination. Proliferating helper T cells that develop into effector T cells differentiate into two major subtypes of cells known as T1 and T2 cells (also known as Type 1 and Type 2 helper T cells, respectively). T1 helper cells lead to an increased cell-mediated response, typically against intracellular bacteria and protozoa. They are triggered by IL-12 and their effector cytokines are IFN-γ and IL-2. The main effector cells of T1 immunity are macrophages as well as CD8 T cells, IgG B cells,