Barbie been sold with a wide range of titles including "Miss Astronaut Barbie" (1965), "Doctor Barbie" (1988), and "Nascar Barbie" (1998). Mattel has created a range of companions for Barbie, including Hispanic Teresa, Midge, African American Christie, and Steven (Christie's boyfriend). Barbie's siblings and cousins were also created including Skipper, Todd and Stacie (twin brother and sister), Kelly, Krissy, and Francie. Barbie was friendly with Blaine, an Australian surfer, during her split with Ken in 2004. Body Image From the start, some have complained that "the blonde, plastic doll conveyed an unrealistic body image to girls." Criticisms of Barbie are often
RTS,S which was added a chemical adjuvant (AS01) to increase the immune system response. Infection is prevented by inducing humoral and cellular immunity, with high antibody titers, that block the parasite from infecting the liver. The T-cell epitope of CSP is O-fucosylated in "Plasmodium falciparum" and "Plasmodium vivax", while the RTS,S vaccine produced in yeast is not. RTS,S RTS,S/AS01 — trade name Mosquirix — is a recombinant protein-based malaria vaccine. Approved for use by European regulators in July 2015, it is the world's first licensed malaria vaccine and also the first vaccine licensed for use against a human parasitic disease of