Santa's Little Helper event; however, their plan fails and a drunk shark that's discovered at the event becomes the new mascot instead. Santa's Little Helper gladly returns to the Simpson family. Santa's Little Helper's initial appearance on "The Simpsons" was in the first episode of the series, "Simpsons Roasting on an Open Fire", which aired on Dec. 17, 1989. Since then, he has become a recurring character. "The Simpsons" creator Matt Groening told "TV Guide" in 2000 that "we [the staff] painted ourselves into a corner with our Christmas episode. Once we wrote the dog into the show, we were stuck with him."
T helper 3 cell T helper 3 cell T helper 3 cells (T3) are white blood cells of the lymphocyte type. They are involved in regulating the body's immune response. The function of T helper cells generally is to mediate the immune response by secreting cytokines and interacting with B-cells to enhance or inhibit their activity. This is of particular importance in the gut as this is where the highest load of foreign material, food, is present. T3 cells are involved in mucosal immunity and protecting mucosal surfaces in the gut from non-pathogenic non-self antigens. They mediate this non-inflammatory environment by secreting TGF-β and