Sonic the Hedgehog different media including animation, comic books, and a Hollywood film. The first "Sonic" game, "Sonic the Hedgehog", is a platform game released in 1991. Players control the anthropomorphic blue hedgehog Sonic, who can run and jump at high speeds using springs, ramps, and loops. Sonic must stop Dr. Robotnik from taking over the world using the Chaos Emeralds. "Sonic the Hedgehog 2" (1992) increased the overall size and speed of the series' gameplay and was the second best-selling Genesis game. It introduced Sonic's sidekick and best friend, Miles "Tails" Prower, who followed Sonic throughout the game, and allowed a second
Sonic hedgehog of prostate cancer tumours. For SHH to be expressed in the developing embryo limbs, a morphogen called fibroblast growth factors must be secreted from the apical ectodermal ridge. Sonic hedgehog has also been shown to act as an axonal guidance cue. It has been demonstrated that SHH attracts commissural axons at the ventral midline of the developing spinal cord. Specifically, SHH attracts retinal ganglion cell (RGC) axons at low concentrations and repels them at higher concentrations. The absence (non-expression) of SHH has been shown to control the growth of nascent hind limbs in cetaceans (whales and dolphins). The sonic hedgehog