Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
Perfect Day (1929 film) was written in May 1929 and filmed between June 1–8, 1929. The original 1929 release of "Perfect Day" contained no music other than that used over the opening credits. The Roach Studios would reissue the film in 1937 with an added music score being utilized at the time in other Roach comedies. The 1929 version was considered lost until the 2011 DVD release "Laurel and Hardy: The Essential Collection", when the original Vitaphone disc track sans the incidental music became available. Adding the soundtrack in 1937 to the existing film resulted in a slight reduction of the correct frame ratio: