Santa's Little Helper Duff Beer that has been spilled on the floor. In another board game published by USAopoly called "The Simpsons Monopoly", based on "Monopoly" and released in 2001, the dog is featured as one of the six pewter playing pieces. Santa's Little Helper has also appeared in issues of "Simpsons Comics", in the 2007 film "The Simpsons Movie", and in video games based on "The Simpsons" such as "Night of the Living Treehouse of Horror" and "The Simpsons Game". In addition, the dog has been made into action figures by McFarlane Toys, action figures by Playmates Toys in the World of
T helper cell because such knowledge may be very useful in the treatment of disease and in increasing the effectiveness of vaccination. Proliferating helper T cells that develop into effector T cells differentiate into two major subtypes of cells known as T1 and T2 cells (also known as Type 1 and Type 2 helper T cells, respectively). T1 helper cells lead to an increased cell-mediated response, typically against intracellular bacteria and protozoa. They are triggered by IL-12 and their effector cytokines are IFN-γ and IL-2. The main effector cells of T1 immunity are macrophages as well as CD8 T cells, IgG B cells,