Mast cell stabilizer Mast cell stabilizer Mast cell stabilizers are chromone medications used to prevent or control certain allergic disorders. They block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate. As inhalers they are used to treat asthma, as nasal sprays to treat hay fever (allergic rhinitis) and as eye drops for allergic conjunctivitis. Finally, in oral form, they are used to treat the rare condition of mastocytosis. Mast cell
Should Have Known Better Should Have Known Better "Should Have Known Better" is a song by American singer-songwriter and multi-instrumentalist Sufjan Stevens. It is the second track and second single from his seventh studio album, "Carrie & Lowell", and was released digitally on March 11, 2015 on Asthmatic Kitty. A promotional CD was later released on Asthmatic Kitty but was not available for sale. ""Should Have Known Better"" received very positive reviews from contemporary music critics. The song was chosen upon release as Pitchfork Media's "Best New Track". Jeremy Gordon stated that, " 'Should Have Known Better' takes us back to the beginning he