Santa's Little Helper real-life breed will paint a different picture — of dogs that are peaceful, affectionate, [and] not given to drooling, panting". Some ideas for episodes featuring Santa's Little Helper come from reality. The plot of "Dog of Death" was based on Swartzwelder's experiences with his own dog, which had also suffered from bloat. However, unlike the events in the episode, Swartzwelder's dog did not receive treatment as the operation was too expensive and the dog was too old. "The Gold Coast Bulletin"s Ryan Ellem commented in 2005 that the Simpson family's dilemma with the cost of the veterinary procedure is a
T helper cell because such knowledge may be very useful in the treatment of disease and in increasing the effectiveness of vaccination. Proliferating helper T cells that develop into effector T cells differentiate into two major subtypes of cells known as T1 and T2 cells (also known as Type 1 and Type 2 helper T cells, respectively). T1 helper cells lead to an increased cell-mediated response, typically against intracellular bacteria and protozoa. They are triggered by IL-12 and their effector cytokines are IFN-γ and IL-2. The main effector cells of T1 immunity are macrophages as well as CD8 T cells, IgG B cells,