Edward Jenner humans a cowpox vaccine against smallpox. For example, Dorset farmer Benjamin Jesty successfully vaccinated and presumably induced immunity with cowpox in his wife and two children during a smallpox epidemic in 1774, but it was not until Jenner's work that the procedure became widely understood. Jenner may have been aware of Jesty's procedures and success. A similar observation had also been made in France by Jacques Antoine Rabaut-Pommier in 1780. Noting the common observation that milkmaids were generally immune to smallpox, Jenner postulated that the pus in the blisters that milkmaids received from cowpox (a disease similar to smallpox, but
Royal Edward (1796 ship) then renamed her. Though volumes of "Lloyd's Register" and the "Register of Shipping" give a capture year of 1796, she does not enter "Lloyd's Register" before 1798. She sailed as a West Indiaman before entering into the slave trade. First slave voyage (1799-1800): Captain Thomas Bushell sailed from England on 4 September 1799. She gathered her slaves at Bonny Island, and arrived at Kingston, Jamaica on 14 July 1800. She had embarked 432 slaves and she disembarked 316, for a loss rate of 8.3%. "Royal Edward" left Jamaica on 18 October and arrived back at Liverpool on 23 December. She