Sonic the Hedgehog platforming of the main levels. The 16-bit "Sonic the Hedgehog " consisted of a giant rotating maze, which many considered a major technical achievement. The most common special stages, however, were segments with the character running through a long tunnel to collect certain items. 3D "collect item" levels, as in "Sonic 3" and "Sonic & Knuckles", used the same perspective but had Sonic collecting all the blue-colored orbs on the surface of a giant sphere. Finally, "Sonic Advance 2" employed a 3D ring-collecting stage, and "Sonic Chaos" ("Sonic and Tails" in Japan) used a variety of gimmicks for its levels.
Sonic hedgehog but low in the developing bronchi. Mice who are deficient in SHH can develop tracheoesophageal fistula (abnormal connection of the esophagus and trachea). Additionally, it a double (SHH-/- ) knockout mouse model exhibited poor lung development. The lungs of the SHH double knockout failed to undergo lobation and branching (the abnormal lungs only developed one branch compared to an extensively branched phenotype of the wildtype). Sonic hedgehog may play a role in mammalian hair cell regeneration. By modulating retinoblastoma protein activity in rat cochlea, sonic hedgehog allows mature hair cells that normally cannot return to a proliferative state to divide