Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
HMS Valentine (L69) Second Battle of Heligoland Bight. An attempt by "Valentine" and the destroyer to carry out a torpedo attack on German cruisers proved unsuccessful. In 1919, "Valentine" was deployed to the Baltic Sea as part of the British intervention in the Russian Civil War, which helped to ensure the independence of the Baltic states. Post-war, "Valentine" formed part of the 2nd Destroyer Flotilla, first as part of the Atlantic Fleet and later as part of the Mediterranean Fleet. In the 1920s, "Valentine"s twin torpedo tubes were replaced by triple tubes, giving a torpedo armament of six 21 inch torpedoes, and the