Santa's Little Helper for "The Tampa Tribune" listed Santa's Little Helper at number six, writing: "We admire his upbeat nature even after having his legs broken by Mr. Burns and being abandoned by Bart for another dog, Laddie." He also ranked 75th on Retrocrush author Robert Berry's list of "The 100 Greatest Dogs of Pop Culture History" in 2006. The character has attracted some criticism too, though. While reviewing the episode "Bart's Dog Gets an F" in 2010, Nathan Rabin of "The A.V. Club" wrote: "As cartoon dogs go, Santa’s Little Helper is spectacularly unspectacular. In a realm of aggressively anthropomorphic canines, some
T helper cell because such knowledge may be very useful in the treatment of disease and in increasing the effectiveness of vaccination. Proliferating helper T cells that develop into effector T cells differentiate into two major subtypes of cells known as T1 and T2 cells (also known as Type 1 and Type 2 helper T cells, respectively). T1 helper cells lead to an increased cell-mediated response, typically against intracellular bacteria and protozoa. They are triggered by IL-12 and their effector cytokines are IFN-γ and IL-2. The main effector cells of T1 immunity are macrophages as well as CD8 T cells, IgG B cells,