Santa's Little Helper for "The Tampa Tribune" listed Santa's Little Helper at number six, writing: "We admire his upbeat nature even after having his legs broken by Mr. Burns and being abandoned by Bart for another dog, Laddie." He also ranked 75th on Retrocrush author Robert Berry's list of "The 100 Greatest Dogs of Pop Culture History" in 2006. The character has attracted some criticism too, though. While reviewing the episode "Bart's Dog Gets an F" in 2010, Nathan Rabin of "The A.V. Club" wrote: "As cartoon dogs go, Santa’s Little Helper is spectacularly unspectacular. In a realm of aggressively anthropomorphic canines, some
T helper 3 cell T helper 3 cell T helper 3 cells (T3) are white blood cells of the lymphocyte type. They are involved in regulating the body's immune response. The function of T helper cells generally is to mediate the immune response by secreting cytokines and interacting with B-cells to enhance or inhibit their activity. This is of particular importance in the gut as this is where the highest load of foreign material, food, is present. T3 cells are involved in mucosal immunity and protecting mucosal surfaces in the gut from non-pathogenic non-self antigens. They mediate this non-inflammatory environment by secreting TGF-β and