3-5-8 3-5-8 3-5-8, also known as Sergeant Major for its popularity among members of Britain's Royal Air Force, is a trick-taking card game for 3 players, using a standard 52 card deck. 3-5-8 may be played as a gambling game, or not, and there are many variations with names like "8-5-3" and "9-5-2" played throughout the world. The version "9-5-3 variation with no kitty" was played in the Royal Navy over fifty years ago, when fellow crew would sit around to continue their game from the previous night. 3 players use a 52-card deck. The object is to win as many
7+3 (chemotherapy) anthracyclines. Addition of glucocorticoids (like prednisolone) or methotrexate or alkylating drugs (like cyclophosphamide or melphalan) to the "7+3" regimen is also of no benefit in AML. The addition of etoposide to the standard "7+3" regimen is "sometimes" of benefit in poor-risk patients (many of which are primary refractory to standard "7+3" induction regimens). It gave rise to the so-called ADE (or DAE = DA + etoposide) induction regimen in AML. The ADE induction (unlike, say, combinations of 7+3 with vinca alkaloids or prednisolone) is still sometimes used, especially in poor-risk AML patients. The addition of 6-thioguanine gave rise to the