Santa's Little Helper of their sacrifices and starts treating him badly, causing him to run away. He ends up in the possession of Mr. Burns, who trains him to become a vicious attack dog. Several days later, Bart stumbles upon the trained Santa's Little Helper and is attacked, but the greyhound eventually recognizes his old friend and stops. In "The Canine Mutiny" (season eight, 1997), Bart uses a fake charge card to buy a well-trained rough collie named Laddie from a mail-order catalog. Laddie learns many tricks that Santa's Little Helper is completely unable to perform, and the Simpson family nearly forgets about
T helper 3 cell T helper 3 cell T helper 3 cells (T3) are white blood cells of the lymphocyte type. They are involved in regulating the body's immune response. The function of T helper cells generally is to mediate the immune response by secreting cytokines and interacting with B-cells to enhance or inhibit their activity. This is of particular importance in the gut as this is where the highest load of foreign material, food, is present. T3 cells are involved in mucosal immunity and protecting mucosal surfaces in the gut from non-pathogenic non-self antigens. They mediate this non-inflammatory environment by secreting TGF-β and