Sonic the Hedgehog platforming of the main levels. The 16-bit "Sonic the Hedgehog " consisted of a giant rotating maze, which many considered a major technical achievement. The most common special stages, however, were segments with the character running through a long tunnel to collect certain items. 3D "collect item" levels, as in "Sonic 3" and "Sonic & Knuckles", used the same perspective but had Sonic collecting all the blue-colored orbs on the surface of a giant sphere. Finally, "Sonic Advance 2" employed a 3D ring-collecting stage, and "Sonic Chaos" ("Sonic and Tails" in Japan) used a variety of gimmicks for its levels.
Sonic hedgehog including the limb and midline structures in the brain, spinal cord, the thalamus by the "zona limitans intrathalamica" the lungs, and the teeth. Mutations in the human sonic hedgehog gene, "SHH", cause holoprosencephaly type 3 HPE3 as a result of the loss of the ventral midline. Sonic hedgehog is secreted at the zone of polarizing activity, which is located on the posterior side of a limb bud in an embryo. The sonic hedgehog transcription pathway has also been linked to the formation of specific kinds of cancerous tumors, including the embryonic cerebellar tumor, and medulloblastoma, as well as the progression