Santa's Little Helper barrier, allowing the dog to understand Bart's commands, and consequently pass the obedience school. Santa's Little Helper has fathered several puppies. In "Two Dozen and One Greyhounds" (season six, 1995), he runs away to the dog racing track where he mates with a female hound named She's the Fastest. She later gives birth to 25 puppies and when the Simpsons cannot take care of them any longer, they decide to sell them; however, Mr. Burns steals the puppies and decides to make a tuxedo out of them. Before he does this, however, he becomes emotionally touched by them. This convinces
T helper 3 cell T helper 3 cell T helper 3 cells (T3) are white blood cells of the lymphocyte type. They are involved in regulating the body's immune response. The function of T helper cells generally is to mediate the immune response by secreting cytokines and interacting with B-cells to enhance or inhibit their activity. This is of particular importance in the gut as this is where the highest load of foreign material, food, is present. T3 cells are involved in mucosal immunity and protecting mucosal surfaces in the gut from non-pathogenic non-self antigens. They mediate this non-inflammatory environment by secreting TGF-β and