HEK 293 cells cell, all of which are abundant in kidneys. However, the original adenovirus transformation was inefficient, suggesting that the cell that finally produced the HEK 293 line may have been unusual in some fashion. Graham and coworkers provided evidence that HEK 293 cells and other human cell lines generated by adenovirus transformation of human embryonic kidney cells have many properties of immature neurons, suggesting that the adenovirus preferentially transformed a neuronal lineage cell in the original kidney culture. A comprehensive study of the genomes and transcriptomes of HEK 293 and five derivative cell lines compared the HEK 293 transcriptome with that
Nevada State Route 487 designation until 1942, other state maps show the route number existing on the highway by 1937. The route was upgraded to a gravel road by 1948, and was fully paved by 1949. SR 73 was eliminated from the state highway system as part of a mass renumbering of Nevada's state routes. The State Route 487 designation was assigned to the former alignment of SR 73 on July 1, 1976. The resulting change in the highway number was first seen on the 1978–79 edition of the official highway map. Since its re-designation as SR 487, there has not been any major