5 to 9 the episode's central character, "In "5 to 9," we get more face time with Cuddy, and she's less of a cypher than usual, but her true nature remains tantalizingly out of reach." Handlen commented that the episode had some good scenes, but ultimately did little to advance the show, grading it "B". TV Squad's Jonathan Toomey raised similar issues, noting that "'5 to 9' wasn't a bad episode (in many ways, it felt like a back-door pilot for Cuddy), but it was, in a word, pointless." Toomey wrote that "At the end of the day, '5 to 9' doesn't really
7+3 (chemotherapy) doxorubicin or idarubicin or mitoxantrone). There were attempts to intensify the "7+3" regimen in order to try to improve its efficacy. Attempts were made to prolong the course (cytarabine for 10 days instead of 7, or daunorubicin/idarubicin for 4–5 days instead of 3). On the other hand, there were attempts to minimize the toxicity of the regimen by reducing the dose or the duration of the course. But this proved to compromise the efficacy of the regimen. The addition of vinca alkaloids (vincristine or vinblastine) to the "7+3" regimen, which addition was quite popular in AML in old times (when