Smallpox 1718. In 1721, Cotton Mather and colleagues provoked controversy in Boston by inoculating hundreds. In 1796, Edward Jenner, a doctor in Berkeley, Gloucestershire, rural England, discovered that immunity to smallpox could be produced by inoculating a person with material from a cowpox lesion. Cowpox is a poxvirus in the same family as variola. Jenner called the material used for inoculation vaccine, from the root word "vacca", which is Latin for cow. The procedure was much safer than variolation, and did not involve a risk of smallpox transmission. Vaccination to prevent smallpox was soon practiced all over the world. During the
Caitlyn Jenner a six-minute film featuring Jenner, called "Caitlyn Jenner's Greatest Victories: A Timeline". In a "20/20" interview with Diane Sawyer in April 2015, Jenner came out as a trans woman, saying that she had dealt with gender dysphoria since her youth and that, "for all intents and purposes, I'm a woman." Jenner cross-dressed for many years and took hormone replacement therapy but stopped after her romance with Kris Kardashian became more serious, leading to marriage in 1992. Jenner recounts having permission to explore her gender identity on her own travels but not when they were coupled, and that not knowing the