Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
Valentine Holmes at Hunter Stadium. In November 2018, Valentine Holmes was released from his contract with the Cronulla Sharks in the National Rugby League to chase his dream to one day play in the National Football League. Valentine Holmes Valentine Holmes (born 24 July 1995) is an Australian former professional rugby league footballer who played as a er or for the Cronulla-Sutherland Sharks in the National Rugby League. An Australia international and also a Queensland State of Origin representative, he spent his entire career to date with the Sharks, with whom he won the 2016 NRL Premiership. Holmes was born in Townsville,