Smallpox 1718. In 1721, Cotton Mather and colleagues provoked controversy in Boston by inoculating hundreds. In 1796, Edward Jenner, a doctor in Berkeley, Gloucestershire, rural England, discovered that immunity to smallpox could be produced by inoculating a person with material from a cowpox lesion. Cowpox is a poxvirus in the same family as variola. Jenner called the material used for inoculation vaccine, from the root word "vacca", which is Latin for cow. The procedure was much safer than variolation, and did not involve a risk of smallpox transmission. Vaccination to prevent smallpox was soon practiced all over the world. During the
Kendall Jenner two signature nail lacquers for the 2011 Nicole by OPI Kardashian Kolors nail polish line, for which the Jenner sisters eventually earned a combined in endorsement profit. On March 16, 2012, the Jenner sisters were named Creative Directors of the "Gillette Venus Gets Ready with Kendall & Kylie Jenner" webisode series, which was originally aired on Gillette's Facebook page. In July 2013, the Jenner sisters formed a partnership with Pascal Mouawad's Glamhouse to create the "Metal Haven by Kendall & Kylie" jewelry collection. In February 2014, the Jenner sisters launched a shoe and handbag line under Steve Madden's "Madden Girl"