Simpsons Roasting on an Open Fire watch the dog's owner angrily disowning him for losing the race. Bart pleads with Homer to keep the dog as a pet, and he reluctantly agrees. When Bart and Homer return home, Homer finally comes clean to the family that he did not get his Christmas bonus; however, the family assumes Santa's Little Helper is their present and are overjoyed by Homer's gesture. The Simpsons family then celebrate by singing "Rudolph the Red-Nosed Reindeer". "The Simpsons" creator Matt Groening conceived of the idea for the Simpsons in the lobby of James L. Brooks's office. Brooks, the producer of the sketch
T helper 3 cell T helper 3 cell T helper 3 cells (T3) are white blood cells of the lymphocyte type. They are involved in regulating the body's immune response. The function of T helper cells generally is to mediate the immune response by secreting cytokines and interacting with B-cells to enhance or inhibit their activity. This is of particular importance in the gut as this is where the highest load of foreign material, food, is present. T3 cells are involved in mucosal immunity and protecting mucosal surfaces in the gut from non-pathogenic non-self antigens. They mediate this non-inflammatory environment by secreting TGF-β and