HEK 293 cells cell, all of which are abundant in kidneys. However, the original adenovirus transformation was inefficient, suggesting that the cell that finally produced the HEK 293 line may have been unusual in some fashion. Graham and coworkers provided evidence that HEK 293 cells and other human cell lines generated by adenovirus transformation of human embryonic kidney cells have many properties of immature neurons, suggesting that the adenovirus preferentially transformed a neuronal lineage cell in the original kidney culture. A comprehensive study of the genomes and transcriptomes of HEK 293 and five derivative cell lines compared the HEK 293 transcriptome with that
How to Change the World How to Change the World How to Change the World: Social Entrepreneurs and the Power of New Ideas is a book by journalist David Bornstein about successful social innovation. It was first published in 2003 and an updated edition followed in 2007. The book explores the definition of a social entrepreneur in the modern world, and provides examples of ordinary people who formed organizations centered on making a difference. Bornstein's purpose is "to call attention to the role of a particular type of actor who propels social change." Bornstein also discusses the rising global trend towards social entrepreneurialism, arguing that