Santa's Little Helper the show in minor appearances, although there have been some episodes that feature him heavily, including the first episode of "The Simpsons". In that episode, "Simpsons Roasting on an Open Fire" (season one, 1989), Homer discovers that he has no money to buy Christmas presents for the family. Desperate for a miracle, he and Bart go to the greyhound racing track on Christmas Eve in hopes of winning some money. Although Homer has inside information on which dog is the most likely to win, he instead bets on a last-minute entry, Santa's Little Helper (here despite being brown), believing the
T helper 3 cell T helper 3 cell T helper 3 cells (T3) are white blood cells of the lymphocyte type. They are involved in regulating the body's immune response. The function of T helper cells generally is to mediate the immune response by secreting cytokines and interacting with B-cells to enhance or inhibit their activity. This is of particular importance in the gut as this is where the highest load of foreign material, food, is present. T3 cells are involved in mucosal immunity and protecting mucosal surfaces in the gut from non-pathogenic non-self antigens. They mediate this non-inflammatory environment by secreting TGF-β and