Dogtown (The Simpsons) run animal medicine places like the poor Dr. Budgie, who gets arrested and put into shackles. Dr. Budgie's plea for Springfield to realize that the dogs will soon notice that humans have advocated their alpha status and turn on the citizens isn't taken seriously until it actually happens. Even Santa's Little Helper joins the feral dog pack, as the town hides from the now-vicious dogs, and a town meeting leads to the community begging their most broken-down citizen to help them: Gil. Gil's ready to face down his fellow street creatures, but it's Marge who steps up, and after finding
T helper cell because such knowledge may be very useful in the treatment of disease and in increasing the effectiveness of vaccination. Proliferating helper T cells that develop into effector T cells differentiate into two major subtypes of cells known as T1 and T2 cells (also known as Type 1 and Type 2 helper T cells, respectively). T1 helper cells lead to an increased cell-mediated response, typically against intracellular bacteria and protozoa. They are triggered by IL-12 and their effector cytokines are IFN-γ and IL-2. The main effector cells of T1 immunity are macrophages as well as CD8 T cells, IgG B cells,