Dogtown (The Simpsons) run animal medicine places like the poor Dr. Budgie, who gets arrested and put into shackles. Dr. Budgie's plea for Springfield to realize that the dogs will soon notice that humans have advocated their alpha status and turn on the citizens isn't taken seriously until it actually happens. Even Santa's Little Helper joins the feral dog pack, as the town hides from the now-vicious dogs, and a town meeting leads to the community begging their most broken-down citizen to help them: Gil. Gil's ready to face down his fellow street creatures, but it's Marge who steps up, and after finding
Brother's Little Helper which Homer and Marge go to see. Homer says that, since taking Focusyn, Bart has gone "from Goofus to Gallant", a reference to the characters Goofus and Gallant from the children's magazine "Highlights". When Lou sketches Bart based on Homer and Marge's description he ends up drawing Dennis from the comic strip "Dennis the Menace". A shirt at the military base Fort Fragg reads "I Went to the Persian Gulf and All I Got Was This Lousy Syndrome", a reference to Gulf War syndrome. In its original American broadcast on October 3, 1999, "Brother's Little Helper" finished at no. 51