Santa's Little Helper him to never wear fur again and instead raise the puppies to be world-class racing dogs. Santa's Little Helper sires another litter of puppies with Dr. Hibbert's poodle in the episode "Today I Am a Clown" (season 15, 2003). These puppies are given away to townspeople. The dog has been neglected or treated unfavorably by the family in some episodes. In "Dog of Death" (season three, 1992), he nearly dies of bloat and they decide to make budget cuts in order to pay for the required operation. Although the dog's life is saved, the family begins to feel the strain
Brother's Little Helper which Homer and Marge go to see. Homer says that, since taking Focusyn, Bart has gone "from Goofus to Gallant", a reference to the characters Goofus and Gallant from the children's magazine "Highlights". When Lou sketches Bart based on Homer and Marge's description he ends up drawing Dennis from the comic strip "Dennis the Menace". A shirt at the military base Fort Fragg reads "I Went to the Persian Gulf and All I Got Was This Lousy Syndrome", a reference to Gulf War syndrome. In its original American broadcast on October 3, 1999, "Brother's Little Helper" finished at no. 51