Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
Valentine (film) Valentine (film) Valentine is a 2001 American slasher film directed by Jamie Blanks, and starring Denise Richards, David Boreanaz, Marley Shelton, Jessica Capshaw, and Katherine Heigl. Loosely based on the novel of the same name by Tom Savage, the film follows a group of women in San Francisco who are stalked by a man whom they tormented during their childhood. Release theatrically in February 2001, the film was critically panned, with critics deeming it too similar to 1980s slasher films. The film earned $36.7 million on a $29 million budget. At a junior high school St. Valentine's Day dance in