Sonic the Hedgehog Sonic the Hedgehog Sonic the Hedgehog is a video game franchise produced by Sega centering on a series of high-speed platform games. Sonic, the protagonist, is an anthropomorphic blue hedgehog with supersonic speed. Typically, Sonic must stop antagonist Doctor Eggman's plans for world domination, often helped by his friends, such as Tails, Amy, and Knuckles. The first "Sonic the Hedgehog" game, released in 1991, was conceived by Sega's Sonic Team division after Sega requested a mascot character to compete with Nintendo's mascot Mario. Its success spawned many sequels and helped Sega become one of the leading video game companies during
Sonic hedgehog but low in the developing bronchi. Mice who are deficient in SHH can develop tracheoesophageal fistula (abnormal connection of the esophagus and trachea). Additionally, it a double (SHH-/- ) knockout mouse model exhibited poor lung development. The lungs of the SHH double knockout failed to undergo lobation and branching (the abnormal lungs only developed one branch compared to an extensively branched phenotype of the wildtype). Sonic hedgehog may play a role in mammalian hair cell regeneration. By modulating retinoblastoma protein activity in rat cochlea, sonic hedgehog allows mature hair cells that normally cannot return to a proliferative state to divide