Santa's Little Helper and is the center of the plots of several episodes. During the course of the show, he has fathered litters of puppies, passed obedience school, had surgery for bloat, replaced Duffman as the mascot for Duff Beer, and been trained as a police dog at Springfield's Animal Police Academy. Some of the episodes that focus on Santa's Little Helper have been inspired by popular culture or real experiences that staff members of the show have gone through. Although cartoon animals are often anthropomorphized, Santa's Little Helper generally exhibits canine behavior. Cast member Dan Castellaneta currently provides the dog's sounds on
T helper 3 cell T helper 3 cell T helper 3 cells (T3) are white blood cells of the lymphocyte type. They are involved in regulating the body's immune response. The function of T helper cells generally is to mediate the immune response by secreting cytokines and interacting with B-cells to enhance or inhibit their activity. This is of particular importance in the gut as this is where the highest load of foreign material, food, is present. T3 cells are involved in mucosal immunity and protecting mucosal surfaces in the gut from non-pathogenic non-self antigens. They mediate this non-inflammatory environment by secreting TGF-β and