Edward Jenner spread around Europe and was used "en masse" in the Spanish Balmis Expedition (1803–1806), a three-year-long mission to the Americas, the Philippines, Macao, China, led by Dr. Francisco Javier de Balmis with the aim of giving thousands the smallpox vaccine. The expedition was successful, and Jenner wrote, "I don’t imagine the annals of history furnish an example of philanthropy so noble, so extensive as this." Napoleon, who at the time was at war with Britain, had all his French troops vaccinated, awarded Jenner a medal, and at the request of Jenner he released two English prisoners of war and permitted
Royal Edward (1796 ship) then renamed her. Though volumes of "Lloyd's Register" and the "Register of Shipping" give a capture year of 1796, she does not enter "Lloyd's Register" before 1798. She sailed as a West Indiaman before entering into the slave trade. First slave voyage (1799-1800): Captain Thomas Bushell sailed from England on 4 September 1799. She gathered her slaves at Bonny Island, and arrived at Kingston, Jamaica on 14 July 1800. She had embarked 432 slaves and she disembarked 316, for a loss rate of 8.3%. "Royal Edward" left Jamaica on 18 October and arrived back at Liverpool on 23 December. She