Santa's Little Helper prompted satires of contemporary dog culture, from Barbara Woodhouse's authoritarian training methods [in "Bart's Dog Gets an F"] to Lassie's flawless service to the status quo [in "The Canine Mutiny"]." Although cast member Dan Castellaneta occasionally voiced Santa's Little Helper for bit parts, American voice artist Frank Welker most often provided the sounds of the dog and other animals on the show from "Bart's Dog Gets an F", which aired on March 7, 1991, to "Home Sweet Homediddly-Dum-Doodily", which aired on October 1, 1995. He said on his official website in 2007 that he liked portraying Santa's Little Helper because
T helper 3 cell T helper 3 cell T helper 3 cells (T3) are white blood cells of the lymphocyte type. They are involved in regulating the body's immune response. The function of T helper cells generally is to mediate the immune response by secreting cytokines and interacting with B-cells to enhance or inhibit their activity. This is of particular importance in the gut as this is where the highest load of foreign material, food, is present. T3 cells are involved in mucosal immunity and protecting mucosal surfaces in the gut from non-pathogenic non-self antigens. They mediate this non-inflammatory environment by secreting TGF-β and