Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
Karen Valentine opposite hosts Dick Stewart and Wink Martindale, and during that time she appeared on another Chuck Barris show, "The Dating Game". In 1969, Valentine won her breakthrough role as a new teacher on the ABC television series "Room 222" with Lloyd Haynes and Michael Constantine. She was discovered by Gene Reynolds, the director of "Room 222", who saw her lip-synching in rehearsal and realized she was funny. She was nominated twice for an Emmy and once for a Golden Globe, winning an Emmy in 1970 for Outstanding Actress in a Supporting Role. Valentine later starred in her own television series,