Santa's Little Helper prompted satires of contemporary dog culture, from Barbara Woodhouse's authoritarian training methods [in "Bart's Dog Gets an F"] to Lassie's flawless service to the status quo [in "The Canine Mutiny"]." Although cast member Dan Castellaneta occasionally voiced Santa's Little Helper for bit parts, American voice artist Frank Welker most often provided the sounds of the dog and other animals on the show from "Bart's Dog Gets an F", which aired on March 7, 1991, to "Home Sweet Homediddly-Dum-Doodily", which aired on October 1, 1995. He said on his official website in 2007 that he liked portraying Santa's Little Helper because
T helper cell because such knowledge may be very useful in the treatment of disease and in increasing the effectiveness of vaccination. Proliferating helper T cells that develop into effector T cells differentiate into two major subtypes of cells known as T1 and T2 cells (also known as Type 1 and Type 2 helper T cells, respectively). T1 helper cells lead to an increased cell-mediated response, typically against intracellular bacteria and protozoa. They are triggered by IL-12 and their effector cytokines are IFN-γ and IL-2. The main effector cells of T1 immunity are macrophages as well as CD8 T cells, IgG B cells,