Santa's Little Helper real-life breed will paint a different picture — of dogs that are peaceful, affectionate, [and] not given to drooling, panting". Some ideas for episodes featuring Santa's Little Helper come from reality. The plot of "Dog of Death" was based on Swartzwelder's experiences with his own dog, which had also suffered from bloat. However, unlike the events in the episode, Swartzwelder's dog did not receive treatment as the operation was too expensive and the dog was too old. "The Gold Coast Bulletin"s Ryan Ellem commented in 2005 that the Simpson family's dilemma with the cost of the veterinary procedure is a
Brother's Little Helper medication. The episode features former Major League Baseball player Mark McGwire as himself. Finishing in 51st place, ratings for "Brother's Little Helper" were considered disappointing by "Deseret News", although the episode became the most watched program on the network that night. Following its broadcast, the episode was positively received by critics. In response to the episode, five months after the episode originally aired, United States president Bill Clinton held the first ever White House conference on Mental Health. Principal Skinner holds a Fire Prevention site at the Springfield Elementary Schoolyard. Then a skit featuring Ned and Maude Flanders goes awry.