Rhinitis goblet cells replace ciliated columnar epithelial cells in the nasal mucous membrane. This results in mucin hypersecretion by goblet cells and decreased mucociliary activity. Nasal secretion are not adequately cleared with clinical manifestation of nasal congestion, sinus pressure, post-nasal dripping, and headache. Over-expression of transient receptor potential (TRP) ion channels, such as TRPA1 and TRPV1, may be involved in the pathogenesis of non-allergic rhinitis. Neurogenic inflammation produced by neuropeptides released from sensory nerve endings to the airways is a proposed common mechanism of association between both allergic and non-allergic rhinitis with asthma. This may explain higher association of rhinitis with
U Should've Known Better U Should've Known Better "U Should've Known Better" is a song by American recording artist Monica. It was written in collaboration with Harold Lilly and Jermaine Dupri, and produced by the latter along with frequent co-producer Bryan Michael Cox for her original third studio album, "All Eyez on Me" (2002). When the album was shelved for release outside Japan, the song was one out of five original records that were transferred into its new version, "After the Storm" (2003). A contemporary R&B slow jam, "U Should've Known Better" contains elements of soul music and rock music. Built on an pulsating