Saab 9-3 muffler and tip, heavy duty clutch and pressure plate, stiffened and lowered springs, firmer dampers, as well as stronger CV joints and driveshafts. In 1999, the Viggen was the first 9-3 to use Saab's Trionic 7 engine management system. The 2001 model year introduced a Traction Control System (TCS). The TCS was later made available in the SE line. The car featured a rear wing that required relocating the radio antenna, aerodynamically designed bumpers and side skirts, special bolstered and colored leather seats (in four colors: black with black inserts (charcoal), black with blue inserts (deep blue), black with orange
7+3 (chemotherapy) anthracyclines. Addition of glucocorticoids (like prednisolone) or methotrexate or alkylating drugs (like cyclophosphamide or melphalan) to the "7+3" regimen is also of no benefit in AML. The addition of etoposide to the standard "7+3" regimen is "sometimes" of benefit in poor-risk patients (many of which are primary refractory to standard "7+3" induction regimens). It gave rise to the so-called ADE (or DAE = DA + etoposide) induction regimen in AML. The ADE induction (unlike, say, combinations of 7+3 with vinca alkaloids or prednisolone) is still sometimes used, especially in poor-risk AML patients. The addition of 6-thioguanine gave rise to the