Santa's Little Helper him to never wear fur again and instead raise the puppies to be world-class racing dogs. Santa's Little Helper sires another litter of puppies with Dr. Hibbert's poodle in the episode "Today I Am a Clown" (season 15, 2003). These puppies are given away to townspeople. The dog has been neglected or treated unfavorably by the family in some episodes. In "Dog of Death" (season three, 1992), he nearly dies of bloat and they decide to make budget cuts in order to pay for the required operation. Although the dog's life is saved, the family begins to feel the strain
T helper cell because such knowledge may be very useful in the treatment of disease and in increasing the effectiveness of vaccination. Proliferating helper T cells that develop into effector T cells differentiate into two major subtypes of cells known as T1 and T2 cells (also known as Type 1 and Type 2 helper T cells, respectively). T1 helper cells lead to an increased cell-mediated response, typically against intracellular bacteria and protozoa. They are triggered by IL-12 and their effector cytokines are IFN-γ and IL-2. The main effector cells of T1 immunity are macrophages as well as CD8 T cells, IgG B cells,