Ze339 Ze339 Ze339 brand herbal extracts are taken from the leaves of a unique variety (Petzell) of the butterbur ("Petasites hybridus") plant. Petzell is grown on GAP-managed farms in Europe. In Switzerland, South Korea and Brazil, tablets containing Ze339 brand herbal extracts are marketed under the brand name Tesalin. Ze339 is marketed in the US as Zarbee's Naturals Seasonal Relief. Ze339 is indicated for seasonal allergic rhinitis (hay fever). The ingredient has been evaluated in placebo-controlled, double-blind clinical studies. Ze339 was shown to be as effective as the antihistamines cetirizine and fexofenadine. Against desloratadine, an improved version of loratadine, Ze339 had
Rhinitis to as "mixed rhinitis". The pathology of vasomotor rhinitis appears to involve neurogenic inflammation and is as yet not very well understood. The role of transient receptor potential ion channels on the non-neuronal nasal epithelial cells has also been suggested. Overexpression of these receptors have influence the nasal airway hyper-responsiveness to non-allergic irritant environmental stimuli (e.g., extremes of temperature, changes in osmotic or barometric pressure). Vasomotor rhinitis appears to be significantly more common in women than men, leading some researchers to believe that hormone imbalance plays a role. In general, age of onset occurs after 20 years of age, in