Para-equestrian classification 4, 5, 6, 7, 12a/b, 13, 14, 21, 26a, 31a/b and 32 are allowed to have a whip which is held or used by a groom. Grade 1 drivers with Profiles 1, 2, 3, 4, 5, 6, 7, 9, 10a, 12a/b, 13, 14, 26a, 31a/b and 32 are allowed to have a brake operated by a groom. Grade 1 drivers with Profiles 1, 2, 3, 4, 5, 6, 7, 9, 10a, 12a/b, 13, 14, 26a, 31a/b and 32 are allowed to have a strap on feet or foot trough. Grade II is for riders who are higher functioning than Grade
7+3 (chemotherapy) anthracyclines. Addition of glucocorticoids (like prednisolone) or methotrexate or alkylating drugs (like cyclophosphamide or melphalan) to the "7+3" regimen is also of no benefit in AML. The addition of etoposide to the standard "7+3" regimen is "sometimes" of benefit in poor-risk patients (many of which are primary refractory to standard "7+3" induction regimens). It gave rise to the so-called ADE (or DAE = DA + etoposide) induction regimen in AML. The ADE induction (unlike, say, combinations of 7+3 with vinca alkaloids or prednisolone) is still sometimes used, especially in poor-risk AML patients. The addition of 6-thioguanine gave rise to the