Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
Valentine Kiss Valentine Kiss The single ranked at number 2 on the Oricon charts, and was rated fourth most popular on music program "The Best Ten" on TBS. It was also awarded the Japan Gold Disc Award for Best Single of the Year. While the title of the song is "Valentine Kiss", due to the often repeated chorus line of "Valentine Day kiss", the song is often called "Valentine Day Kiss". "Valentine Kiss" was reproduced by Kokushō and resold in 2008 by Sony Music Direct. This remake reached number 135 on the Oricon charts. "Valentine Kiss" was the ending theme song for