Sonic the Hedgehog (1991 video game) 1 Boomed", a ROM hack which implements Sonic's redesign from the "Sonic Boom" animated series. Sonic the Hedgehog (1991 video game) The game's development began in 1990 when Sega ordered its in-house development team to create a game featuring a mascot for the company. After considering a number of suggestions, the developers decided on a blue hedgehog with spikes along his head and spine and named themselves "Sonic Team" to match their character. "Sonic the Hedgehog", designed for fast gameplay, was influenced by the games of "Super Mario" series creator, Shigeru Miyamoto. "Sonic the Hedgehog" uses a novel technique that
Sonic hedgehog but low in the developing bronchi. Mice who are deficient in SHH can develop tracheoesophageal fistula (abnormal connection of the esophagus and trachea). Additionally, it a double (SHH-/- ) knockout mouse model exhibited poor lung development. The lungs of the SHH double knockout failed to undergo lobation and branching (the abnormal lungs only developed one branch compared to an extensively branched phenotype of the wildtype). Sonic hedgehog may play a role in mammalian hair cell regeneration. By modulating retinoblastoma protein activity in rat cochlea, sonic hedgehog allows mature hair cells that normally cannot return to a proliferative state to divide