Santa's Little Helper real-life breed will paint a different picture — of dogs that are peaceful, affectionate, [and] not given to drooling, panting". Some ideas for episodes featuring Santa's Little Helper come from reality. The plot of "Dog of Death" was based on Swartzwelder's experiences with his own dog, which had also suffered from bloat. However, unlike the events in the episode, Swartzwelder's dog did not receive treatment as the operation was too expensive and the dog was too old. "The Gold Coast Bulletin"s Ryan Ellem commented in 2005 that the Simpson family's dilemma with the cost of the veterinary procedure is a
T helper 3 cell T helper 3 cell T helper 3 cells (T3) are white blood cells of the lymphocyte type. They are involved in regulating the body's immune response. The function of T helper cells generally is to mediate the immune response by secreting cytokines and interacting with B-cells to enhance or inhibit their activity. This is of particular importance in the gut as this is where the highest load of foreign material, food, is present. T3 cells are involved in mucosal immunity and protecting mucosal surfaces in the gut from non-pathogenic non-self antigens. They mediate this non-inflammatory environment by secreting TGF-β and