Human body temperature to give the most accurate assessment of core body temperature, particularly in hypothermia. In the early 2000s, ingestible thermistors in capsule form were produced, allowing the temperature inside the digestive tract to be transmitted to an external receiver; one study found that these were comparable in accuracy to rectal temperature measurement. In the 19th century, most books quoted "blood heat" as 98 °F, until a study published the mean (but not the variance) of a large sample as . Subsequently that mean was widely quoted as "37 °C or 98.4 °F" until editors realised 37 °C is closer to 98.6
Operating temperature temperature is also one of the classic phase markers for measuring the timing of an individual's Circadian rhythm. Changes to the normal human body temperature may result in discomfort. The most common such change is a fever, a temporary elevation of the body's thermoregulatory set-point, typically by about 1–2 °C (1.8–3.6 °F). Hyperthermia is an acute condition caused by the body absorbing more heat than it can dissipate, whereas hypothermia is a condition in which the body's core temperature drops below that required for normal metabolism, and which is caused by the body's inability to replenish the heat that is