Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
Perfect Day (1929 film) sound effects to punctuate a visual gag — a technique The Three Stooges would build their entire film career around — was still in its infancy in 1929. The loud, ringing CLANG heard when Stan is beaned on the head with the Model T's clutch would be termed by a 1929 film reviewer as "the funniest effect so far heard in a comedy." The second half of the Stooges' 1948 film "Pardon My Clutch" and its remake, "Wham Bam Slam", is a remake of "Perfect Day". Chapters — called Tents — of The Sons of the Desert, the international Laurel