Sonic the Hedgehog (1991 video game) 1 Boomed", a ROM hack which implements Sonic's redesign from the "Sonic Boom" animated series. Sonic the Hedgehog (1991 video game) The game's development began in 1990 when Sega ordered its in-house development team to create a game featuring a mascot for the company. After considering a number of suggestions, the developers decided on a blue hedgehog with spikes along his head and spine and named themselves "Sonic Team" to match their character. "Sonic the Hedgehog", designed for fast gameplay, was influenced by the games of "Super Mario" series creator, Shigeru Miyamoto. "Sonic the Hedgehog" uses a novel technique that
Sonic hedgehog of prostate cancer tumours. For SHH to be expressed in the developing embryo limbs, a morphogen called fibroblast growth factors must be secreted from the apical ectodermal ridge. Sonic hedgehog has also been shown to act as an axonal guidance cue. It has been demonstrated that SHH attracts commissural axons at the ventral midline of the developing spinal cord. Specifically, SHH attracts retinal ganglion cell (RGC) axons at low concentrations and repels them at higher concentrations. The absence (non-expression) of SHH has been shown to control the growth of nascent hind limbs in cetaceans (whales and dolphins). The sonic hedgehog