HEK 293 cells cell, all of which are abundant in kidneys. However, the original adenovirus transformation was inefficient, suggesting that the cell that finally produced the HEK 293 line may have been unusual in some fashion. Graham and coworkers provided evidence that HEK 293 cells and other human cell lines generated by adenovirus transformation of human embryonic kidney cells have many properties of immature neurons, suggesting that the adenovirus preferentially transformed a neuronal lineage cell in the original kidney culture. A comprehensive study of the genomes and transcriptomes of HEK 293 and five derivative cell lines compared the HEK 293 transcriptome with that
A Change of Heart (How I Met Your Mother) Cohn of Television Without Pity graded the episode at B−. Robert Canning of IGN gave the episode a rating of 8.5 out of 10, saying that Nora was likeable and that he enjoyed the interaction between the friends, who even managed to make "silly filler plots" enjoyable. A Change of Heart (How I Met Your Mother) "A Change of Heart" is the 18th episode of the sixth season of the CBS sitcom "How I Met Your Mother" and the 130th episode overall. It originally aired on February 28, 2011. After Nora announces her intention to marry and settle down, Barney