Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
The Valentine his collection of art and artifacts, the 1812 John Wickham House and a $50,000 endowment. Their collection of art and artifacts was the foundation of the exhibitions, when the Valentine Museum opened in 1898. Part of the original intent of the founding of the museum was to display these archeological artifacts in perpetuity, after the family was embarrassed by an archeological hoax in North Carolina. When it opened, the Valentine Museum was the first private museum in the City of Richmond Mann S. Valentine II's brother Edward Virginius Valentine also had an interest in history and was a well-known sculptor.