Santa's Little Helper and Tiger (50th). According to a writer for McClatchy News Service, the rankings were "determined by popularity, name recognition and how long the show lasted." Among fans and critics, Santa's Little Helper has been mostly well received. He ranked seventh in a 2008 poll by "Dog Whisperer"s Cesar Millan that determined the "best-loved television dog of all time." Lassie ranked first in the poll. In addition, he was voted the tenth favorite "Simpsons" character by readers of "Simpsons Comics" in the United Kingdom in 2010. In a list of their top twelve favorite dogs from cartoons, comics, and animation, writers
T helper cell because such knowledge may be very useful in the treatment of disease and in increasing the effectiveness of vaccination. Proliferating helper T cells that develop into effector T cells differentiate into two major subtypes of cells known as T1 and T2 cells (also known as Type 1 and Type 2 helper T cells, respectively). T1 helper cells lead to an increased cell-mediated response, typically against intracellular bacteria and protozoa. They are triggered by IL-12 and their effector cytokines are IFN-γ and IL-2. The main effector cells of T1 immunity are macrophages as well as CD8 T cells, IgG B cells,