Sonic the Hedgehog has been that the variant gameplay styles found in recent 3D games have strayed from the formula of the original series. Specifically, the series' jump to 3D has been noted as a declining point. In late 2010, Sega delisted several below-average "Sonic" games, such as the notoriously disliked 2006 game "Sonic the Hedgehog", to increase the value of the "Sonic" brand after positive reviews for the games "" and "Sonic Colors". Sonic the Hedgehog Sonic the Hedgehog is a video game franchise produced by Sega centering on a series of high-speed platform games. Sonic, the protagonist, is an anthropomorphic blue
Sonic hedgehog but low in the developing bronchi. Mice who are deficient in SHH can develop tracheoesophageal fistula (abnormal connection of the esophagus and trachea). Additionally, it a double (SHH-/- ) knockout mouse model exhibited poor lung development. The lungs of the SHH double knockout failed to undergo lobation and branching (the abnormal lungs only developed one branch compared to an extensively branched phenotype of the wildtype). Sonic hedgehog may play a role in mammalian hair cell regeneration. By modulating retinoblastoma protein activity in rat cochlea, sonic hedgehog allows mature hair cells that normally cannot return to a proliferative state to divide