Penicillin nontoxic in humans by first performing toxicity tests in animals and then on humans. His subsequent experiments on penicillin's response to heat and pH allowed Fleming to increase the stability of the compound. The one test that modern scientists would find missing from his work was the test of penicillin on an infected animal, the results of which would likely have sparked great interest in penicillin and sped its development by almost a decade. The importance of his work has been recognized by the placement of an International Historic Chemical Landmark at the Alexander Fleming Laboratory Museum in London on
Karen Valentine opposite hosts Dick Stewart and Wink Martindale, and during that time she appeared on another Chuck Barris show, "The Dating Game". In 1969, Valentine won her breakthrough role as a new teacher on the ABC television series "Room 222" with Lloyd Haynes and Michael Constantine. She was discovered by Gene Reynolds, the director of "Room 222", who saw her lip-synching in rehearsal and realized she was funny. She was nominated twice for an Emmy and once for a Golden Globe, winning an Emmy in 1970 for Outstanding Actress in a Supporting Role. Valentine later starred in her own television series,