Sonic the Hedgehog Sonic the Hedgehog Sonic the Hedgehog is a video game franchise produced by Sega centering on a series of high-speed platform games. Sonic, the protagonist, is an anthropomorphic blue hedgehog with supersonic speed. Typically, Sonic must stop antagonist Doctor Eggman's plans for world domination, often helped by his friends, such as Tails, Amy, and Knuckles. The first "Sonic the Hedgehog" game, released in 1991, was conceived by Sega's Sonic Team division after Sega requested a mascot character to compete with Nintendo's mascot Mario. Its success spawned many sequels and helped Sega become one of the leading video game companies during
Sonic hedgehog are thought to be successively patterned throughout the neural tube by the SHH concentration gradient. Mutual inhibition between pairs of transcription factors expressed in neighboring domains contributes to the development of sharp boundaries, however, in some cases, inhibitory relationship has been found even between pairs of transcription factors from more distant domains. Particularly, NKX2-2 expressed in the V3 domain is reported to inhibit IRX3 expressed in V2 and more dorsal domains, although V3 and V2 are separated by a further domain termed MN. Sonic hedgehog (SHH) is a signaling molecule that is encoded by the same gene sonic hedgehog. SHH