Santa's Little Helper real-life breed will paint a different picture — of dogs that are peaceful, affectionate, [and] not given to drooling, panting". Some ideas for episodes featuring Santa's Little Helper come from reality. The plot of "Dog of Death" was based on Swartzwelder's experiences with his own dog, which had also suffered from bloat. However, unlike the events in the episode, Swartzwelder's dog did not receive treatment as the operation was too expensive and the dog was too old. "The Gold Coast Bulletin"s Ryan Ellem commented in 2005 that the Simpson family's dilemma with the cost of the veterinary procedure is a
Helper dependent virus and capsid encoding DNA, plus helper DNA. Every cell that is successfully transfected with all three DNA fragments will produce the necessary proteins to produce infective viruses. These viruses will only have transgenic DNA encapsidated and therefore once they've infected a patient's cell, they will not be capable of reproducing. Helper dependent viruses can also occur in nature without being "gutted". The term satellite virus has been given to a large group of viruses that all require the presence of another virus to replicate. Many of these are plant viruses, but animal viruses can be seen in the case of