Allergic inflammation The recruited eosinophils will degranulate releasing a number of cytotoxic molecules (including Major Basic Protein and eosinophil peroxidase) as well as produce a number of cytokines such as IL-5. The recruited T-cells are typically of the Th2 variety and the cytokines they produce lead to further recruitment of mast cells and eosinophils, and in plasma cell isotype switching to IgE which will bind to the mast cell FcεRI receptors and prime the individual for further allergic responses. Allergic inflammation Allergic inflammation is an important pathophysiological feature of several disabilities or medical conditions including allergic asthma, atopic dermatitis, allergic rhinitis and
Double Allergic space. Powderfinger spent less money producing "Double Allergic" than on their previous works. Previously, the band had worked with Tony Cohen, whom Fanning stated was expensive due to his success in the industry. For "Double Allergic" the band chose Tim Whitten, a less well known producer, and because the band knew what they intended to do as they entered the studio they managed to spend less despite the improved sound. Middleton commented on Whitten's capabilities in the recording studio, saying "He's what a band looks for in a producer/engineer, because he's got his own ideas", but stating that Whitten would