Sonic the Hedgehog has been that the variant gameplay styles found in recent 3D games have strayed from the formula of the original series. Specifically, the series' jump to 3D has been noted as a declining point. In late 2010, Sega delisted several below-average "Sonic" games, such as the notoriously disliked 2006 game "Sonic the Hedgehog", to increase the value of the "Sonic" brand after positive reviews for the games "" and "Sonic Colors". Sonic the Hedgehog Sonic the Hedgehog is a video game franchise produced by Sega centering on a series of high-speed platform games. Sonic, the protagonist, is an anthropomorphic blue
Sonic hedgehog are thought to be successively patterned throughout the neural tube by the SHH concentration gradient. Mutual inhibition between pairs of transcription factors expressed in neighboring domains contributes to the development of sharp boundaries, however, in some cases, inhibitory relationship has been found even between pairs of transcription factors from more distant domains. Particularly, NKX2-2 expressed in the V3 domain is reported to inhibit IRX3 expressed in V2 and more dorsal domains, although V3 and V2 are separated by a further domain termed MN. Sonic hedgehog (SHH) is a signaling molecule that is encoded by the same gene sonic hedgehog. SHH