Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
Valentine, Texas Valentine, Texas Valentine is a town in Jeff Davis County, Texas, United States. The population was 134 at the 2010 census, down from 187 at the 2000 census. It is the only incorporated municipality in Jeff Davis County. Its name refers to the date of its founding in 1882 by a Southern Pacific Railroad construction crew: February 14. It is one of several cities named Valentine in the United States where the U.S. Postal Service cancels envelopes for Valentine's Day. The noted art installation Prada Marfa (2005) is located northwest of Valentine on U.S. 90. The John Wayne film "Cahill