Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
The Valentine and Textile" exhibit shows vintage clothes. The Valentine has several rotating exhibitions that include photographs, clothes and textiles and historical based exhibits that impacted Richmond in a significant way. The Valentine The Valentine is a museum in Richmond, Virginia dedicated to the history of the city. Founded by Mann S. Valentine II 1898, it was the first museum in Richmond. The Valentine offers exhibitions that focus on "American urban and social history, costumes and textiles, decorative arts and architecture." The Valentine also includes the 1812 neoclassical Wickham House, a National Historical Landmark. In 2014, the Valentine completed a $4.1 million