Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
Saint Valentine Saint Valentine Saint Valentine (, ), officially Saint Valentine of Rome, was a widely recognized 3rd-century Roman saint commemorated on February 14 and since the High Middle Ages is associated with a tradition of courtly love. All that is reliably known of the saint commemorated on February 14 is his name and that he was martyred and buried at a cemetery on the Via Flaminia close to the Ponte Milvio to the north of Rome on that day. It is uncertain whether Saint Valentine was one individual or a pseudonym for several. Several different martyrologies have been added to later