Rhinitis goblet cells replace ciliated columnar epithelial cells in the nasal mucous membrane. This results in mucin hypersecretion by goblet cells and decreased mucociliary activity. Nasal secretion are not adequately cleared with clinical manifestation of nasal congestion, sinus pressure, post-nasal dripping, and headache. Over-expression of transient receptor potential (TRP) ion channels, such as TRPA1 and TRPV1, may be involved in the pathogenesis of non-allergic rhinitis. Neurogenic inflammation produced by neuropeptides released from sensory nerve endings to the airways is a proposed common mechanism of association between both allergic and non-allergic rhinitis with asthma. This may explain higher association of rhinitis with
The Rhinitis Revelation 100 by the TV critic; it was said to be "dull" and "stasis", with Mary's insistence on the gang praying described as "inappropriate". According to the critic, the political incorrectness from Mary was "predictable and basic" and although "Sheldon's refusal to change did feel believable", it was "a bit of a waste of time". The Rhinitis Revelation "The Rhinitis Revelation" is the sixth episode of the fifth season of the US sitcom "The Big Bang Theory" and the 93rd episode of the show overall. It first aired on CBS on October 20, 2011. Sheldon's mother, Mary Cooper, is going on