Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
Valentine S. McClatchy Valentine S. McClatchy Valentine Stuart McClatchy (August 29, 1857 – May 15, 1938) was an American newspaper owner and journalist. As publisher of "The Sacramento Bee" (now The McClatchy Company) from their father's death in 1883, McClatchy co-owned the paper with his brother Charles K. McClatchy until 1923. After leaving the newspaper business, he became a leading figure in the anti-Japanese movement in California, forming key exclusionary groups to lobby for alien land laws and race-based limits on immigration and naturalization. McClatchy was the son of the prominent nineteenth-century publisher James McClatchy, who founded the "Sacramento Bee" (known as the