HEK 293 cells cell, all of which are abundant in kidneys. However, the original adenovirus transformation was inefficient, suggesting that the cell that finally produced the HEK 293 line may have been unusual in some fashion. Graham and coworkers provided evidence that HEK 293 cells and other human cell lines generated by adenovirus transformation of human embryonic kidney cells have many properties of immature neurons, suggesting that the adenovirus preferentially transformed a neuronal lineage cell in the original kidney culture. A comprehensive study of the genomes and transcriptomes of HEK 293 and five derivative cell lines compared the HEK 293 transcriptome with that
Language change may wonder how it was ever possible for a word meaning 'evil' to change its sense to 'wonderful' so quickly." All languages change continually, and do so in many and varied ways. Marcel Cohen details various types of language change under the overall headings of the external evolution and internal evolution of languages. The study of lexical changes forms the diachronic portion of the science of onomasiology. The ongoing influx of new words into the English language (for example) helps make it a rich field for investigation into language change, despite the difficulty of defining precisely and accurately the vocabulary