Chloropyramine Chloropyramine Chloropyramine is a classical ("old", or first-generation) antihistamine drug approved in some Eastern European countries (like Russia) for the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions. Related indications for clinical use include angioedema (Quincke's edema), allergic reactions to insect bites, food and drug allergies, and anaphylactic shock. Chloropyramine is known as a competitive reversible H receptor antagonist (also known as an H inverse agonist), meaning that it exerts its pharmacological action by competing with histamine for the H subtype histamine receptor. By blocking the effects of histamine, the drug inhibits the vasodilation, increased
Seasonal adjustment data can be misleading. This is because the seasonally adjusted series contains both the trend-cycle component and the error component. As such, the seasonally adjusted data will not be "smooth" and what appears to be "downturns" or "upturns" may actually be randomness in the data. For this reason, if the purpose is finding turning points in a series, it is better to use the trend-cycle component rather than the seasonally adjusted data. Seasonal adjustment Seasonal adjustment is a statistical method for removing the seasonal component of a time series that exhibits a seasonal pattern. It is usually done when wanting