Santa's Little Helper him to never wear fur again and instead raise the puppies to be world-class racing dogs. Santa's Little Helper sires another litter of puppies with Dr. Hibbert's poodle in the episode "Today I Am a Clown" (season 15, 2003). These puppies are given away to townspeople. The dog has been neglected or treated unfavorably by the family in some episodes. In "Dog of Death" (season three, 1992), he nearly dies of bloat and they decide to make budget cuts in order to pay for the required operation. Although the dog's life is saved, the family begins to feel the strain
Helper dependent virus and capsid encoding DNA, plus helper DNA. Every cell that is successfully transfected with all three DNA fragments will produce the necessary proteins to produce infective viruses. These viruses will only have transgenic DNA encapsidated and therefore once they've infected a patient's cell, they will not be capable of reproducing. Helper dependent viruses can also occur in nature without being "gutted". The term satellite virus has been given to a large group of viruses that all require the presence of another virus to replicate. Many of these are plant viruses, but animal viruses can be seen in the case of