Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
Valentine, Texas Texas. In July 2011 the USPS announced that the post office may close. Valentine is home to, as one politician puts it, "the greatest ever West Texas Valentine's Day celebration." Hosted by the Big Bend Brewing Company of Alpine, Texas, as many as 1,000 people invade Valentine on Valentine's Day from points as close as Valentine itself, Marfa, and Alpine, to far away places such as Chicago and Cleveland. In 2014, the west Texas brewery served free cups of beer while Gary P. Nunn played live on stage, under the moonlit night and stars. On August 16, 1931, a magnitude