Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
A. S. Valentine of the game after coming to the aid of James Van Cleve during a fight against Pittsburgh's Joe Trees. After several appeals, Valentine left the field reportedly "crying like a baby" by the local media. In 1895, Allegheny declined to field a team after learning of an investigation into the club by the Amateur Athletic Union, over reports that the team had been secretly paying players. As a result, Valentine became a referee. He officiated a game that year between the Duquesne Country and Athletic Club and Greensburg. The game was filled with fights and arguments. Valentine refused to return