Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
Uncle Valentine noise from works being done on the newly purchased house, jarring the ambience and atmosphere of the rural place. Uncle Valentine Uncle Valentine is a short story by Willa Cather. It was first published in "Woman's Home Companion" in February 1925. A music teacher is giving a lesson to an American girl, who says she has been practising songs by Valentine Ramsay. The teacher says another lady in the room can tell her more about him. Marjorie explains Valentine was her uncle. One day, her Aunt Charlotte is getting ready for her brother to come back after leaving for Europe