Rhinitis goblet cells replace ciliated columnar epithelial cells in the nasal mucous membrane. This results in mucin hypersecretion by goblet cells and decreased mucociliary activity. Nasal secretion are not adequately cleared with clinical manifestation of nasal congestion, sinus pressure, post-nasal dripping, and headache. Over-expression of transient receptor potential (TRP) ion channels, such as TRPA1 and TRPV1, may be involved in the pathogenesis of non-allergic rhinitis. Neurogenic inflammation produced by neuropeptides released from sensory nerve endings to the airways is a proposed common mechanism of association between both allergic and non-allergic rhinitis with asthma. This may explain higher association of rhinitis with
Should Have Known Better Should Have Known Better "Should Have Known Better" is a song by American singer-songwriter and multi-instrumentalist Sufjan Stevens. It is the second track and second single from his seventh studio album, "Carrie & Lowell", and was released digitally on March 11, 2015 on Asthmatic Kitty. A promotional CD was later released on Asthmatic Kitty but was not available for sale. ""Should Have Known Better"" received very positive reviews from contemporary music critics. The song was chosen upon release as Pitchfork Media's "Best New Track". Jeremy Gordon stated that, " 'Should Have Known Better' takes us back to the beginning he