Eosinophilic granulomatosis with polyangiitis Eosinophilic granulomatosis with polyangiitis Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg–Strauss syndrome (CSS) or allergic granulomatosis, is an extremely rare autoimmune condition that causes inflammation of small and medium-sized blood vessels (vasculitis) in persons with a history of airway allergic hypersensitivity (atopy). It usually manifests in three stages. The early (prodromal) stage is marked by airway inflammation; almost all patients experience asthma and/or allergic rhinitis. The second stage is characterized by abnormally high numbers of eosinophils (hypereosinophilia), which causes tissue damage, most commonly to the lungs and the digestive tract. The third stage consists of vasculitis, which can
Seasonal adjustment data can be misleading. This is because the seasonally adjusted series contains both the trend-cycle component and the error component. As such, the seasonally adjusted data will not be "smooth" and what appears to be "downturns" or "upturns" may actually be randomness in the data. For this reason, if the purpose is finding turning points in a series, it is better to use the trend-cycle component rather than the seasonally adjusted data. Seasonal adjustment Seasonal adjustment is a statistical method for removing the seasonal component of a time series that exhibits a seasonal pattern. It is usually done when wanting