Santa's Little Helper because there were animation problems with the others. Jean told the "Houston Chronicle" in 2001 that after the first episode was broadcast and "the next seven didn't have the dog, people wondered why." He also said in 2003 that the staff enjoyed the first episodes that centered on him, particularly "Simpsons Roasting on an Open Fire", which is the reason that more episodes about him were written. Writer John Swartzwelder has noted that the staff members of the show write the character Homer in the same way that they write Santa's Little Helper: "Both are loyal. Both have the same
T helper cell because such knowledge may be very useful in the treatment of disease and in increasing the effectiveness of vaccination. Proliferating helper T cells that develop into effector T cells differentiate into two major subtypes of cells known as T1 and T2 cells (also known as Type 1 and Type 2 helper T cells, respectively). T1 helper cells lead to an increased cell-mediated response, typically against intracellular bacteria and protozoa. They are triggered by IL-12 and their effector cytokines are IFN-γ and IL-2. The main effector cells of T1 immunity are macrophages as well as CD8 T cells, IgG B cells,