Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
A. S. Valentine in a game for Shadyside Academy as that team was defeated by the Pittsburgh A.C., 26–0. That same year, he scored a touchdown against the Greensburg Athletic Association, during a 10–5 Allegheny win. During a game against the Detroit Athletic Association on November 11, 1893, Valentine reportedly openly punched Detroit's quarterback so openly. The officials ignored the incident, and the Detroiter used the next play to retaliate against Valentine. Shortly after, a brawl between the two clubs erupted. Allegheny would go on to win the game 18–0. In 1894, during a game against the Pittsburgh A.C., Valentine was thrown out