Simpsons Roasting on an Open Fire watch the dog's owner angrily disowning him for losing the race. Bart pleads with Homer to keep the dog as a pet, and he reluctantly agrees. When Bart and Homer return home, Homer finally comes clean to the family that he did not get his Christmas bonus; however, the family assumes Santa's Little Helper is their present and are overjoyed by Homer's gesture. The Simpsons family then celebrate by singing "Rudolph the Red-Nosed Reindeer". "The Simpsons" creator Matt Groening conceived of the idea for the Simpsons in the lobby of James L. Brooks's office. Brooks, the producer of the sketch
T helper cell because such knowledge may be very useful in the treatment of disease and in increasing the effectiveness of vaccination. Proliferating helper T cells that develop into effector T cells differentiate into two major subtypes of cells known as T1 and T2 cells (also known as Type 1 and Type 2 helper T cells, respectively). T1 helper cells lead to an increased cell-mediated response, typically against intracellular bacteria and protozoa. They are triggered by IL-12 and their effector cytokines are IFN-γ and IL-2. The main effector cells of T1 immunity are macrophages as well as CD8 T cells, IgG B cells,