Charles Harrison Blackley Charles Harrison Blackley Charles Harrison Blackley (5 April 1820 – 4 September 1900) was the discoverer of the mechanism behind allergic rhinitis caused by pollen, commonly called hay fever. The isolation of hay fever as a condition had been known since 1819 through the work of John Bostock. Blackley was the first to connect pollen to the condition, and though he held some later discredited views, his insight was an important step in the research of allergens. His most important work was a book titled the "Experimental Researches on the Causes and Nature of Catarrhus aestivus", published in 1873. Charles
Rhinitis to as "mixed rhinitis". The pathology of vasomotor rhinitis appears to involve neurogenic inflammation and is as yet not very well understood. The role of transient receptor potential ion channels on the non-neuronal nasal epithelial cells has also been suggested. Overexpression of these receptors have influence the nasal airway hyper-responsiveness to non-allergic irritant environmental stimuli (e.g., extremes of temperature, changes in osmotic or barometric pressure). Vasomotor rhinitis appears to be significantly more common in women than men, leading some researchers to believe that hormone imbalance plays a role. In general, age of onset occurs after 20 years of age, in