Human body temperature to give the most accurate assessment of core body temperature, particularly in hypothermia. In the early 2000s, ingestible thermistors in capsule form were produced, allowing the temperature inside the digestive tract to be transmitted to an external receiver; one study found that these were comparable in accuracy to rectal temperature measurement. In the 19th century, most books quoted "blood heat" as 98 °F, until a study published the mean (but not the variance) of a large sample as . Subsequently that mean was widely quoted as "37 °C or 98.4 °F" until editors realised 37 °C is closer to 98.6
Temperature-sensitive mutant Temperature-sensitive mutant Temperature sensitive mutants are variants of genes that allow normal function of the organism at low temperatures, but altered function at higher temperatures. Most temperature sensitive mutations affect proteins, and cause loss of protein function at the non-permissive temperature. The permissive temperature is one at which the protein typically can fold properly, or remain properly folded. At higher temperatures, the protein is unstable and ceases to function properly. These mutations are usually recessive in diploid organisms. The permissive temperature is the temperature at which a temperature sensitive mutant gene product takes on a normal, functional phenotype. When a