9 (2009 animated film) declares 2 as dead, but 9, having seen the condemned factory where the Cat-Beast took him, decides to rescue him. 9 and 5 venture to the factory where they find 2. The Cat-Beast attacks the trio, but are saved by the warrior 7 (Jennifer Connelly). 9, drawn by curiosity, connects the talisman to the derelict Fabrication Machine, reviving it, and it subsequently kills 2 by sucking out his soul. 9, 5, and 7 manage to escape the factory. 7 takes 9 and 5 to an abandoned library, where the mute scholar twins, 3 and 4, show 9 a film showing
7+3 (chemotherapy) doxorubicin or idarubicin or mitoxantrone). There were attempts to intensify the "7+3" regimen in order to try to improve its efficacy. Attempts were made to prolong the course (cytarabine for 10 days instead of 7, or daunorubicin/idarubicin for 4–5 days instead of 3). On the other hand, there were attempts to minimize the toxicity of the regimen by reducing the dose or the duration of the course. But this proved to compromise the efficacy of the regimen. The addition of vinca alkaloids (vincristine or vinblastine) to the "7+3" regimen, which addition was quite popular in AML in old times (when