Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
Saint Valentine that in England no church was ever dedicated to him. There are many churches containing the name of Valentine in other countries such as Italy. A 5th- or 6th-century work called "Passio Marii et Marthae" made up a legend about Saint Valentine's Basilica being dedicated to Saint Valentine in Rome. A later "Passio" repeated the legend and added the adornment that Pope Julius I (357–352) had built the ancient basilica "S. Valentini extra Portam" on top of his sepulchre, in the Via Flaminia. This church was really named after a 4th-century tribune called Valentino, who donated the land on which