Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira
A. S. Valentine to the game for the second half. A. S. Valentine A. S. Valentine was an early professional football player for the Allegheny Athletic Association. He served as the team's quarterback in 1890 and 1891. However, he jumped to the rival Pittsburgh Athletic Club in 1892. Valentine played for Pittsburgh in their first two games. Then, without warning, he suddenly jumped back to the Allegheny team. Some Pittsburgh A.C. members accused Allegheny of enticing him back, while others charged he had all along been a spy for them. During Allegheny's two games against the Pittsburgh A.C. that year, Valentine played as