HEK 293 cells cell, all of which are abundant in kidneys. However, the original adenovirus transformation was inefficient, suggesting that the cell that finally produced the HEK 293 line may have been unusual in some fashion. Graham and coworkers provided evidence that HEK 293 cells and other human cell lines generated by adenovirus transformation of human embryonic kidney cells have many properties of immature neurons, suggesting that the adenovirus preferentially transformed a neuronal lineage cell in the original kidney culture. A comprehensive study of the genomes and transcriptomes of HEK 293 and five derivative cell lines compared the HEK 293 transcriptome with that
Many-to-many Many-to-many The many-to-many communication paradigm is one of three major Internet computing paradigms, characterized by multiple users contributing and receiving information, with the information elements often interlinked across different websites. Developments such as file sharing, blogs, Wikis, and tagging are media forms that reflect this paradigm; these contrast with both the one-to-one (characterized by e-mail, FTP, and Telnet) and one-to-many (characterized by websites) paradigms. With the evolution to the full "many-to-many" computing paradigm, people can input and receive information to and from the Internet; they will be able to connect and communicate dynamically within a flexibly formed scope; there will