Light effects on circadian rhythm collected by rod cells and cone cells and the retinal ganglion cells (RGCs), or it is directly collected by these RGCs. The RGCs use the photopigment melanopsin to absorb the light energy. Specifically, this class of RGCs being discussed is referred to as "intrinsically photosensitive," which just means they are sensitive to light. There are five known types of intrinsically photosensitive retinal ganglion cells (ipRGCs): M1, M2, M3, M4, and M5. Each of these differently ipRGC types have different melanopsin content and photosensitivity. These connect to amacrine cells in the inner plexiform layer of the retina. Ultimately, via this retinohypothalamic
Giant retinal ganglion cells an S-Off, (L + M)-On opponency. Their spatial modulation transfer function is low-pass, with an upper limit of about 0.6 cycles per degree. Dacey "et al". propose that the giants subserve the subconscious, 'non-image-forming' functions of circadian photoentrainment and pupillary diameter, and via the rod and cone inputs, may help mediate conscious perception of irradiance. Giant retinal ganglion cells Giant retinal ganglion cells are photosensitive ganglion cells with large dendritic trees discovered in the human and macaque retina by Dacey "et al". (2005). Giant retinal ganglion cells contain a photo-pigment, melanopsin, allowing them to respond directly to light. They also