Menstrual cycle occur as a result of adopting a restricted diet, as well as engaging in a high amount of exercise. Finally, the cycle is affected more by a vegetarian diet compared to a non-vegetarian diet. Studies investigating effects of the menstrual cycle on alcohol consumption have found mixed evidence. However, some evidence suggests that individuals consume more alcohol during the luteal stage, especially if these individuals are heavy drinkers or have a family history of alcohol abuse. The level of substance abuse increases with PMS, mostly with addictive substances such as nicotine, tobacco and cocaine. One theory behind this suggests this
Topical progesterone of tissue exposure to progesterone with this route of administration. These findings provide a possible explanation for how some studies found antiproliferative and atrophic changes in the endometrium with topical progesterone. However, elevated levels of progesterone in the endometrium with topical progesterone have not yet been demonstrated. Concern has been raised regarding topical progesterone in that the effects of such supraphysiological levels of progesterone in tissues are unknown and hence the potential for harmful effects has not been ruled out. Salivary monitoring of progesterone levels in women using topical progesterone and adjustment of dosage as necessary has been suggested as