Antibiotic resistance in gonorrhea Antibiotic resistance in gonorrhea The Gonorrhea bacterium Neisseria gonorrhoeae has developed antibiotic resistance to many antibiotics. The bacteria was first identified in 1879, although some Biblical scholars believe that references to the disease can be found as early as Parshat Metzora of the Old Testament. In the 1940s effective treatment with penicillin became available, but by the 1970s resistant strains predominated. Resistance to penicillin has developed through two mechanisms: chromasomally mediated resistance (CMRNG) and penicillinase-mediated resistance (PPNG). CMRNG involves step wise mutation of penA, which codes for the penicillin-binding protein (PBP-2); mtr, which encodes an efflux pump that removes penicillin
Antibiotic sensitivity antibiotic sensitivity testing offered as one combined service. This is because the clinician needs to know which organism is causing the infection, and which drugs will specifically work against this strain. Jump up ^ http://www.uphs.upenn.edu/bugdrug/antibiotic_manual/bk.html Jump up ^ http://www.slideshare.net/doctorrao/antibiotic-sensitivity-testing-presentation Jump up ^ http://cid.oxfordjournals.org/content/49/11/1749.full Jump up ^ http://www.microrao.com/micronotes/antibiotic.pdf Antibiotic sensitivity Antibiotic sensitivity or antibiotic susceptibility is the susceptibility of bacteria to antibiotics. Because susceptibility can vary even within a species (with some strains being more resistant than others), antibiotic susceptibility testing (AST) is usually carried out to determine which antibiotic will be most successful in treating a bacterial infection in vivo.