Multiple endocrine neoplasia type 1 ATR. The exact function of MEN1 and the protein, menin, produced by this gene is not known, but following the inheritance rules of the "two-hit hypothesis" indicates that it acts as a tumor suppressor. In a diagnostic workup individuals with a combination of endocrine neoplasias suggestive of the "MEN1 syndrome" are recommended to have a mutational analysis of the MEN1 gene if additional diagnostic criteria are sufficiently met, mainly including: Multiple endocrine neoplasia or MEN is part of a group of disorders that affect the body's network of hormone-producing glands (the endocrine system). Hormones are chemical messengers that travel through
Gastric glands neck cells" that produce mucus. This is thought to be different from the mucus produced by the gastric mucosa. Fundic glands found in the fundus and also in the body have another two cell types–gastric chief cells and parietal cells (oxyntic)). The chief cells are found in the basal regions of the gland and release a zymogen – pepsinogen, a precursor to pepsin. The parietal cells ("parietal" means "relating to a wall") are found in the walls of the tubes. The parietal cells secrete hydrochloric acid–the main component of gastric acid. This needs to be readily available for the stomach