Macula of retina is seen when viewed from the pupil, as in ophthalmoscopy or retinal photography. The anatomical macula is defined histologically in terms of having two or more layers of ganglion cells. The umbo is the center of the foveola which in turn is located at the center of the fovea. The fovea is located near the center of the macula. It is a small pit that contains the largest concentration of cone cells. The retina contains two types of photosensitive cells, the rod cells and the cone cells. Because the macula is yellow in colour it absorbs excess blue and ultraviolet
Gene therapy of the human retina vector on embryonic day 14 shows efficient transduction of retinal pigment epithelium in the RPE65-/- knockout mice and rescues visual functions. This shows successful gene therapy can be attributed to early intraocular deliver to the diseased animal. Juvenile retinoschisis is a disease that affects the nerve tissue in the eye. This disease is an X-linked recessive degenerative disease of the central macula region, and it is caused by mutation in the RSI gene encoding the protein retinoschisin. Retinoschisin is produced in the photoreceptor and bipolar cells and it is critical in maintaining the synaptic integrity of the retina. Specifically the