Endocrine disruptor to have committed scientific misconduct. Found in many household and industrial products, endocrine disruptors are substances that "interfere with the synthesis, secretion, transport, binding, action, or elimination of natural hormones in the body that are responsible for development, behavior, fertility, and maintenance of homeostasis (normal cell metabolism)." They are sometimes also referred to as hormonally active agents, endocrine disrupting chemicals, or endocrine disrupting compounds. The variety of terms used to describe these substances reflects not only a range of meanings but a range of connotations, with "endocrine disruptor" emphasizing harmful effects, while "hormonally active agent" or "xenohormone" are more neutral,
Homeostasis regulating metabolism, reproduction, eating and drinking behaviour, energy utilization, osmolarity and blood pressure. The regulation of metabolism, is carried out by hypothalamic interconnections to other glands. Three endocrine glands of the hypothalamic–pituitary–gonadal axis (HPG axis) often work together and have important regulatory functions. Two other regulatory endocrine axes are the hypothalamic–pituitary–adrenal axis (HPA axis) and the hypothalamic–pituitary–thyroid axis (HPT axis). The liver also has many regulatory functions of the metabolism. An important function is the production and control of bile acids. Too much bile acid can be toxic to cells and its synthesis can be inhibited by activation of FXR