Transgender hormone therapy (male-to-female) medical professional. Inducers of CYP3A4 and other cytochrome P450 enzymes can reduce the effects of MTF HRT. A variety of different sex-hormonal medications are used in feminizing hormone therapy for transgender women. These include estrogens to induce feminization and suppress testosterone levels; antiandrogens such as androgen receptor antagonists, antigonadotropins, GnRH modulators, and 5α-reductase inhibitors to further oppose the effects of androgens like testosterone; and progestogens for various possible though uncertain benefits. Estrogens are the major sex hormones in women, and are responsible for the development and maintenance of feminine secondary sexual characteristics, such as breasts, wide hips, and a feminine
Sexual selection in mammals neck length is not correlated to increases in other parts of the body, which would be expected from foraging selection, so sexual selection may be a more satisfactory explanation. Studies have failed to resolve the causes involved: perhaps the neck was a result of both or other forces. Precopulatory mechanisms determine who father an offspring prior to sex. Male-male competition is the biggest precopulatory mechanism in mammals. Sexual dimorphism is a result of male-male competition that is easily seen in species. Male-male competition to copulate with the opposite sex is often seen in mammals. African elephants strongly promote male-male competition.