Molecular models of DNA simulations that are very important to understand how DNA functions "in vivo". From the very early stages of structural studies of DNA by X-ray diffraction and biochemical means, molecular models such as the Watson-Crick nucleic acid double helix model were successfully employed to solve the 'puzzle' of DNA structure, and also find how the latter relates to its key functions in living cells. The first high quality X-ray diffraction patterns of A-DNA were reported by Rosalind Franklin and Raymond Gosling in 1953. Rosalind Franklin made the critical observation that DNA exists in two distinct forms, A and B, and produced
Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid autobiographical account of the discovery of the double-helical, molecular structure of DNA called "The Double Helix", which was not publicly accepted either by Crick or Wilkins. Furthermore, Erwin Chargaff also printed a rather "unsympathetic review" of Watson's book in the March 29, 1968 issue of "Science". In the book, Watson stated among other things that he and Crick had access to some of Franklin's data from a source that she was not aware of, and also that he had seen—without her permission—the B-DNA X-ray diffraction pattern obtained by Franklin and Gosling in May 1952 at King's in London. In particular,