Pulmonary vein three and five in the healthy population. The two left lobar veins may be united as a single pulmonary vein in about 25% of people; the two right veins may be united in about 3%. The pulmonary veins play an essential role in respiration, by receiving blood that has been oxygenated in the alveoli and returning it to the left atrium. As part of the pulmonary circulation they carry oxygenated blood back to the heart, as opposed to the veins of the systemic circulation which carry deoxygenated blood. A rare genetic defect of the pulmonary veins can cause them to
Vein directly connect two capillary beds. Examples of such systems include the hepatic portal vein and hypophyseal portal system. The peripheral veins carry blood from the limbs and hands and feet. Microscopically, veins have a thick outer layer made of connective tissue, called the tunica externa or "tunica adventitia". There is a middle layer of bands of smooth muscle called tunica media, which are, in general, much thinner than those of arteries, as veins do not function primarily in a contractile manner and are not subject to the high pressures of systole, as arteries are. The interior is lined with endothelial