Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
Tendon-driven robot Tendon-driven robot Tendon-driven robots (TDR) are robots whose limbs mimic biological musculoskeletal systems. They use plastic straps to mimic muscles and tendons. Such robots are claimed to move in a "more natural" way than traditional robots that use rigid metal or plastic limbs controlled by geared actuators. TDRs can also help understand how biomechanics relates to embodied intelligence and cognition. Challenges include effectively modeling the human body’s complex motions and ensuring accurate positioning, given that the tendons are prone to stretch, which costs them strength and smooth operation. TDRs are the subject of considerable research and commercial systems followed. Myorobotics