Glipizide 10 milligrams. Glipizide sensitizes the beta cells of pancreatic islets of Langerhans insulin response, meaning that more insulin is released in response to glucose than would be without glipizide ingestion. Glipizide acts by partially blocking potassium channels among beta cells of pancreatic islets of Langerhans. By blocking potassium channels, the cell depolarizes, which results in the opening of voltage-gated calcium channels. The resulting calcium influx encourages insulin release from beta cells. Glipizide Glipizide is an oral rapid- and short-acting anti-diabetic medication from the sulfonylurea class. It is classified as a second-generation sulfonylurea, which means that it undergoes enterohepatic circulation. Second-generation
Ryan Langerhans On April 7, Langerhans was designated for assignment to make room for Jesús Colomé. On December 14, 2010, the Mariners again re-signed Langerhans to a minor league contract. On May 9, 2011, Langerhans was again designated for assignment to make room for Mike Wilson. On July 29, 2011, Langerhans was traded to the Arizona Diamondbacks for cash considerations. Langerhans signed a minor league contract with the Los Angeles Angels of Anaheim on December 23, 2011. Ryan was recalled by the Angels on May 14, 2012, when Torii Hunter was placed on the restricted list. On May 20, Langerhans was removed