Glipizide 10 milligrams. Glipizide sensitizes the beta cells of pancreatic islets of Langerhans insulin response, meaning that more insulin is released in response to glucose than would be without glipizide ingestion. Glipizide acts by partially blocking potassium channels among beta cells of pancreatic islets of Langerhans. By blocking potassium channels, the cell depolarizes, which results in the opening of voltage-gated calcium channels. The resulting calcium influx encourages insulin release from beta cells. Glipizide Glipizide is an oral rapid- and short-acting anti-diabetic medication from the sulfonylurea class. It is classified as a second-generation sulfonylurea, which means that it undergoes enterohepatic circulation. Second-generation
Ryan Langerhans of the independent Atlantic League. Langerhans was signed to a minor league contract and assigned to the Buffalo Bisons again on August 22, 2013. When the Bisons season ended, Langerhans asked for and received his release, and returned to the Sugar Land Skeeters for their playoff run. On September 26, Langerhans again signed with the Blue Jays. This time a major league contract as the Blue Jays were short on position players. He became a free agent on October 8, 2013. He hit a game-winning home run against J.P. Howell on August 7, 2009, with two outs in the bottom