Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
Tendon, Vosges Tendon, Vosges Tendon is a commune in the Vosges area of Grand Est in northeastern France. Its inhabitants are known as Todas, there is a village and around 60 settlements in the area. The history of the area dates back to the middle ages. Tendon is a comune in the heart of a long valley, composed of a village and about 60 settlements. Situated 19 kilometres to the East of Épinal, Tendon lies in the valley of the Scouet, a tributary of the Vologne via the Barba. 492 hectares are occupied by forest. Le Tholy is 8 km away via