Allergic inflammation immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema. The late phase of a Type 1 reaction (which develops 8–12
Bee pollen by herbalists as a treatment for a variety of medical conditions, but there is no good evidence that bee pollen has any health benefits other than as a source of nutrition. Potential risks of consuming bee pollen include contamination by fungal mycotoxins, pesticides, or toxic metals. Bee pollen is safe for short term use, but for those with pollen allergies, allergic reactions may occur (shortness of breath, hives, swelling, and anaphylaxis). Bee pollen is not safe for pregnant women and should not be used during breastfeeding. The Food and Drug Administration has warned against the use of some bee pollen