Nucleated red blood cell in the normal development of a normoblast. A megaloblast is an unusually large erythroblast that can be associated with vitamin B deficiency (caused by pernicious anemia or dietary insufficiency), folic acid deficiency, or both (such anemias are collectively called megaloblastic anemias). This kind of anemia leads to macrocytes (abnormally large red cells) and the condition called macrocytosis. The cause of this cellular gigantism is an impairment in DNA replication that delays nuclear maturation and cell division. Because RNA and cytoplasmic elements are synthesized at a constant rate despite the cells' impaired DNA synthesis, the cells show nuclear-cytoplasmic asynchrony. NRB's can
The Blood Cell The Blood Cell The Blood Cell is a BBC Books original novel written by James Goss and based on the long-running British science fiction television series "Doctor Who". It features the Twelfth Doctor and Clara Oswald. The book was released on 11 September 2014 along with "Silhouette" and "The Crawling Terror". "The Blood Cell" gained generally positive reviews, calling it an "effective chiller". Most of them commented the unusual way of narration from the first-person perspective of the administrator of the prison in which the book is set known as the Governor. More grim and darker tone is also noted.