Protein signalling in heart development Protein signalling in heart development The heart is the first functional organ in a vertebrate embryo. There are 5 stages to heart development. Specification of cardiac precursor cells: The lateral plate mesoderm delaminates to form two layers: the dorsal somatic (parietal) mesoderm and the ventral splanchnic (visceral) mesoderm. The heart precursor cells come from the two regions of the splanchnic mesoderm called the cardiogenic mesoderm. These cells can differentiate into endocardium which lines the heart chamber and valves and the myocardium which forms the musculature of the ventricles and the atria. The heart cells are specified in anterior mesoderm by
How Many Licks? VH1 wrote that the single and other tracks from "The Notorious K.I.M." have a "glossier and far more commercial" sound than the rapper's previous releases. The lyrics of "How Many Licks?" are part of a movement in 1990s hip hop music to express sexuality positively. Sexuality studies professor Thomas A. Foster wrote that Lil' Kim reverses a trend in hip hop music which objectifies women for the male gaze and celebrates male sexuality. Gender studies scholar Aine McGlynn described "How Many Licks?" as one of the most sexually-explicit songs to receive airplay. The lyrics describe a woman's interest in oral