Hyaline layer of Hopewell-Smith derivative proteins, such as Emdogain, in trying to stimulate reproduction of cementum in periodontal bony defects is based on the presence of enamel matrix-like proteins within the hyaline layer. Hyaline layer of Hopewell-Smith In tooth development, the hyaline layer of Hopewell-Smith is the most peripheral layer of initially unmineralized dentin that forms immediately subjacent to the cementodentinal junction (CDJ). It eventually mineralizes, but not before the rest of the dentin is already mineralized. It is 0.5-0.8 µm thick and contains enamel matrix-like protein as well as the proteins one would expect to find in dentin. It is into this hyaline
Human tooth ligaments attached to a tooth moving away from it has a high number of osteoblasts, resulting in bone formation. The gingiva ("gums") is the mucosal tissue that overlays the jaws. There are three different types of epithelium associated with the gingiva: gingival, junctional, and sulcular epithelium. These three types form from a mass of epithelial cells known as the epithelial cuff between the tooth and the mouth. The gingival epithelium is not associated directly with tooth attachment and is visible in the mouth. The junctional epithelium, composed of the basal lamina and hemidesmosomes, forms an attachment to the tooth. The