Emissary veins passing through the foramen ovale, jugular foramen, foramen lacerum, and hypoglossal canal. Because the emissary veins are valveless, they are an important part in selective brain cooling through bidirectional flow of cooler blood from the evaporating surface of the head. In general, blood flow is from external to internal but the flow can be altered by increased intracranial pressure. A type of emissary vein goes through the sphenoidal emissary foramen inferior to the zygomatic arch with the cavernous sinus on the inside of the skull. This is an important route for spread of infection because cranial nerve VI and the
Drug delivery to the brain drug that helps it pass through the barrier and then once inside the brain, is degraded in such a way that the drug cannot pass back through the brain. Once the drug cannot pass back through the barrier the drug can be concentrated and made effective for therapeutic use. However drawbacks to this exist as well. Once the drug is in the brain there is a point where it needs to be degraded to prevent overdose to the brain tissue. Also if the drug cannot pass back through the blood–brain barrier, it compounds the issues of dosage and intense monitoring