Antibiotic resistance in gonorrhea Antibiotic resistance in gonorrhea The Gonorrhea bacterium Neisseria gonorrhoeae has developed antibiotic resistance to many antibiotics. The bacteria was first identified in 1879, although some Biblical scholars believe that references to the disease can be found as early as Parshat Metzora of the Old Testament. In the 1940s effective treatment with penicillin became available, but by the 1970s resistant strains predominated. Resistance to penicillin has developed through two mechanisms: chromasomally mediated resistance (CMRNG) and penicillinase-mediated resistance (PPNG). CMRNG involves step wise mutation of penA, which codes for the penicillin-binding protein (PBP-2); mtr, which encodes an efflux pump that removes penicillin
Discovered attack referred to as a "discovered attack" (or "check") "with capture". When the moving piece moves to a square from which it threatens to inflict checkmate on the next move, the tactic is called a "discovered attack with mate threat". A "discovered checkmate" itself is also possible. In exceptional circumstances, it is possible for the moved piece to give a "double discovered check" (though this name is not actually used). The only way for this to happen in orthodox chess is by way of an "en passant" capture. In the position shown at right, Black has just played 1...g7–g5. White replies