Gonadal dysgenesis If a single or combination of these genes are mutated or deleted, downstream signalling is disrupted, leading to malformation of male external genitalia. SRY acts on gene SOX9 which drives Sertoli cell formation and testis differentiation. An absence in SRY causes SOX9 to not be expressed at the appropriate time or concentration, leading to a deficiency in testosterone and Anti-Müllerian hormone production. Inadequate levels of testosterone and Anti-Müllerian hormone disrupts the development of Wolffian ducts and internal genitalia that are key to male reproductive tract development. The lack of the male associated steroid hormones drives Müllerian duct development and perusal
Causes of sexual violence do non-rapists. In one study, male rapists evaluated with penile plethysmography demonstrated more arousal to forced sex and less discrimination between forced and consensual sex than non-rapist control subjects, though both groups responded more strongly to consensual sex scenarios. Data on sexually violent individuals show that most direct their acts at individuals whom they already know. Drug-facilitated sexual assault (DFSA), also known as predator rape, is a sexual assault carried out after the victim has become incapacitated due to having consumed alcoholic beverages or other drugs. Alcohol has been shown to play a disinhibiting role in certain types of sexual