Cone of light Cone of light The cone of light, or light reflex, is a visible phenomenon which occurs upon examination of the tympanic membrane with an otoscope. Shining light on the tympanic membrane causes a cone-shaped reflection of light to appear in the anterior inferior quadrant. This corresponds to the 4 o'clock to 5 o'clock position in the right eardrum and the 7 o'clock to 8 o'clock position in the left eardrum. The apex of the cone is at the most depressed part of the tympanic membrane, known as the umbo. The absence of a cone of light does not necessarily signify
Integral membrane protein at atomic resolution by X-ray crystallography or nuclear magnetic resonance spectroscopy. They are challenging subjects for study owing to the difficulties associated with extraction and crystallization. In addition, structures of many water-soluble protein domains of IMPs are available in the Protein Data Bank. Their membrane-anchoring α-helices have been removed to facilitate the extraction and crystallization. Search integral membrane proteins in the PDB (based on gene ontology classification) IMPs can be divided into two groups: The most common type of IMP is the transmembrane protein (TM), which spans the entire biological membrane. Single-pass membrane proteins cross the membrane only once, while