Ozone depletion iodine atoms participate in analogous catalytic cycles. However, fluorine atoms react rapidly with water and methane to form strongly bound HF in the Earth's stratosphere, while organic molecules containing iodine react so rapidly in the lower atmosphere that they do not reach the stratosphere in significant quantities. A single chlorine atom is able to react with an average of 100,000 ozone molecules before it is removed from the catalytic cycle. This fact plus the amount of chlorine released into the atmosphere yearly by chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs) demonstrates the danger of CFCs and HCFCs to the environment. The ozone
Ozone depletion CFCs means that nitrous oxide (), which is not covered by the Montreal Protocol, has become the most highly emitted ozone-depleting substance and is expected to remain so throughout the 21st century. A 2005 IPCC review of ozone observations and model calculations concluded that the global amount of ozone has now approximately stabilized. Although considerable variability is expected from year to year, including in polar regions where depletion is largest, the ozone layer is expected to begin to recover in coming decades due to declining ozone-depleting substance concentrations, assuming full compliance with the Montreal Protocol. The Antarctic ozone hole is