Β-lactam antibiotic reactions to any β-lactam antibiotic may occur in up to 10% of patients receiving that agent (a small fraction of which are truly IgE-mediated allergic reactions, see amoxicillin rash). Anaphylaxis will occur in approximately 0.01% of patients. There is perhaps a 5%-10% cross-sensitivity between penicillin-derivatives, cephalosporins, and carbapenems; but this figure has been challenged by various investigators. Nevertheless, the risk of cross-reactivity is sufficient to warrant the contraindication of all β-lactam antibiotics in patients with a history of severe allergic reactions (urticaria, anaphylaxis, interstitial nephritis) to any β-lactam antibiotic. A Jarisch–Herxheimer reaction may occur after initial treatment of a spirochetal
Antibiotic use in livestock antibiotic given to the livestock. Since the primary study, there have been many well-documented events showing that antibiotic usage in livestock results in direct influence of antibiotic resistance in humans. Major bacterial infections in humans can be traced back to livestock. The family Enterobacteriaceae includes many opportunistic bacteria, including "E. coli", which are commonly found in livestock. Other bacteria include "Klebsiella" and "Staphylococcus aureus". They cause infections in the urinary tract, digestive system, skin, and bloodstream, and account for a significant portion of antibiotic-resistant bacterial infections. The practice of using antibiotics for growth stimulation is problematic for these reasons: Donald