Pharmacodynamics of progesterone women, this effect being the result of suppression of the mid-cycle surge in gonadotropin secretion, is 300 mg/day. However, this figure is based on limited clinical data. Conversely, treatment with a high dosage of oral progesterone of 100 mg four times per day (or 400 mg/day total) in men for 10 days that resulted in approximately mid-luteal phase levels of progesterone (7.9–9.4 ng/mL; measured by ) did not cause any change in testosterone levels, suggesting that progesterone has little or no antigonadotropic effect in males at typical clinical dosages. In addition, a study found that administration of 1,000 mg/day oral
Menstrual cup investigated whether silicone menstrual cups are a viable alternative to tampons and found that approximately 91% of women in the menstrual cup group said they would continue to use the cup and recommend it to others. In a 1991 clinical study involving 51 women, 23 of the participants (45%) found rubber menstrual cups to be an acceptable way of managing menstrual flow. In a randomized controlled feasibility study in rural western Kenya, adolescent primary school girls were provided with menstrual cups or sanitary pads instead of traditional menstrual care items of cloth or tissue. Girls provided with menstrual cups had