Pacemaker current on hyperpolarization, and very slow kinetics. The funny current is highly expressed in spontaneously active cardiac regions, such as the sinoatrial node (SAN, the natural pacemaker region), the atrioventricular node (AVN) and the Purkinje fibres of conduction tissue. The funny current is a mixed sodium–potassium current that activates upon hyperpolarization at voltages in the diastolic range (normally from −60/−70 mV to −40 mV). When, at the end of a sinoatrial action potential, the membrane repolarizes below the I threshold (about −40/−50 mV), the funny current is activated and supplies inward current, which is responsible for starting the diastolic depolarization phase
Orbital node moves south through the plane. In the case of objects outside the Solar System, the ascending node is the node where the orbiting secondary passes away from the observer, and the descending node is the node where it moves towards the observer. The position of the node may be used as one of a set of parameters, called "orbital elements", which describe the orbit. This is done by specifying the longitude of the ascending node (or, sometimes, the longitude of the node.) The line of nodes is the intersection of the object's orbital plane with the plane of reference. It