Insulin oscillation oscillations. The insulin oscillations are generated by pulsatile release of the hormone from the pancreas. Insulin originates from beta cells located in the islets of Langerhans. Since each islet contains up to 2000 beta cells and there are one million islets in the pancreas it is apparent that pulsatile secretion requires sophisticated synchronization both within and among the islets of Langerhans. Pulsatile insulin secretion from individual beta cells is driven by oscillation of the calcium concentration in the cells. In beta cells lacking contact, the periodicity of these oscillations is rather variable (2-10 min). However, within an islet of Langerhans
Paul Langerhans of his new bride “three indescribably happy years” followed. In autumn of 1887, progressive renal failure brought his medical activities to an end. He developed leg oedema, crippling headaches and transient memory loss. Sometimes he stopped in the middle of a sentence and was unable to continue. He died of uraemia on 20 July 1888, five days before his 41st birthday. He is buried in the British Cemetery of Funchal on Madeira, a place he had chosen, describing it as a “true graveyard, isolated and quiet, a good place to rest.” Paul Langerhans Paul Langerhans (25 July 1847 – 20