Mass-to-charge ratio refers to the molecular or atomic mass number and "z" to the charge number of the ion; however, the quantity of "m"/"z" is dimensionless by definition. An ion of 100 atomic mass units ("m" = 100) carrying two charges ("z" = 2) will be observed at "m"/"z" = 50. In the 19th century, the mass-to-charge ratios of some ions were measured by electrochemical methods. In 1897, the mass-to-charge ratio of the electron was first measured by J. J. Thomson. By doing this, he showed that the electron was in fact a particle with a mass and a charge, and that
Drude particle a changing local environment. Classical Drude particles are massless virtual sites carrying a partial electric charge, attached to individual atoms via a harmonic spring. The spring constant and relative partial charges on the atom and associated Drude particle determine its response to the local electrostatic field, serving as a proxy for the changing distribution of the electronic charge of the atom or molecule. However, this response is limited to a changing dipole moment. This response is not enough to model interactions in environments with large field gradients, which interact with higher order moments. The major computational cost of simulating classical