Atmosphere of Earth International Space Station orbits in this layer, between . The mesosphere is the third highest layer of Earth's atmosphere, occupying the region above the stratosphere and below the thermosphere. It extends from the stratopause at an altitude of about to the mesopause at above sea level. Temperatures drop with increasing altitude to the mesopause that marks the top of this middle layer of the atmosphere. It is the coldest place on Earth and has an average temperature around . Just below the mesopause, the air is so cold that even the very scarce water vapor at this altitude can be
Ozone often considered the higher elevations beneficial because of their ozone content. "There is quite a different atmosphere [at higher elevation] with enough ozone to sustain the necessary energy [to work]", wrote naturalist Henry Henshaw, working in Hawaii. Seaside air was considered to be healthy because of its believed ozone content; but the smell giving rise to this belief is in fact that of halogenated seaweed metabolites. Much of ozone's appeal seems to have resulted from its "fresh" smell, which evoked associations with purifying properties. Scientists, however, noted its harmful effects. In 1873 James Dewar and John Gray McKendrick documented that