Fruit2O to exhibit a synergistic effect wherein the blend is sweeter than its components. The current ingredients vary slightly with each flavor, but generally include purified water, less than 2% of natural flavor, citric acid, tartaric acid, malic acid, sucralose (Splenda), acesulfame potassium, sodium benzoate, and potassium sorbate. It contains no calories, fat, or sugar. Fruit2o Plus 10 ingredients also include ascorbic acid (vitamin C), niacinamide, vitamin B, vitamin B, calcium pantothenate (vitamin B) and biotin (B vitamins), vitamin E acetate, zinc gluconate, magnesium sulfate, sodium selenite, calcium disodium EDTA. Fruit2O FruitO, formerly manufactured by Kraft, is a lightly flavored, non-carbonated
L-gulonolactone oxidase deficiency living in a malarial infested environment". He based his observation on evidence which indicates that G6PD deficient individuals display enhanced sensitivity to ascorbic acid induced hemolysis. Studies of human diseases have benefited from the availability of small laboratory animal models. However, the tissues of animal models with a GULO gene generally have high levels of ascorbic acid and so are often only slightly influenced by exogenous vitamin C. Guinea pigs, for instance, are a popular human model but lost the ability to synthesize L-gulono-gamma-lactone oxidase 20 million years ago. This is a major handicap for studies involving the endogenous