Apparent mineralocorticoid excess syndrome cases recorded worldwide. Liquorice consumption may also cause a temporary form of AME due to its ability to block 11β-hydroxysteroid dehydrogenase type 2, in turn causing increased levels of cortisol. Cessation of licorice consumption will reverse this form of AME. Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In
Water organ contest between Apollo and Marsyas' and 'Apollo and the nine Muses'. The most famous water organ of the 16th century was at the Villa d'Este in Tivoli. Built about 1569–72 by Lucha Clericho (Luc de Clerc; completed by Claude Venard), it stood about six metres high under an arch, and was fed by a magnificent waterfall; it was described by Mario Cartaro in 1575 as playing 'madrigals and many other things'. G. M. Zappi (Annalie memorie de Tivoli, 1576) wrote: 'When somebody gives the order to play, at first one hears trumpets which play a while and then there is