Cultured pearl is calcium carbonate and a fibrous protein called conchiolin. As the nacre builds up in layers of minute aragonite tablets, it fills the growing pearl sac and eventually forms a pearl. Natural pearls are formed by nature, more or less by chance. On the other hand, cultured pearls are human creations formed by inserting a tissue graft from a donor oyster, upon which a pearl sac forms, and the inner side precipitates calcium carbonate, in the form of nacre or "mother-of-pearl". The most popular and effective method for creating cultured pearls are made from the shells of freshwater river mussels
Pearl River (China) as the Pearl River just north of Guangzhou. The Pearl River is famed as the river that flows through Guangzhou. The Pearl River's estuary, Bocca Tigris, is regularly dredged so as to keep it open for ocean vessels. The mouth of the Pearl River forms a large bay in the southeast of the delta, the Pearl River Estuary, the Bocca Tigris separates Shiziyang in the north, Lingdingyang in the south, and Jiuzhouyang at the southern tip of the estuary surrounded by the Wanshan Archipelago. This bay separates Macau and Zhuhai from Hong Kong and Shenzhen. The Pearl River is so