Rimantadine antagonistic properties and is used as an antiparkinsonic drug (i.e., in the treatment of Parkinson's disease). However, in general, neither rimantadine nor amantadine is a preferred agent for this therapy and would be reserved for cases of the disease that are less responsive to front-line treatments. Taking paracetamol (acetaminophen, Tylenol) or acetylsalicylic acid (aspirin) while taking rimantadine is known to reduce the body's uptake of rimantadine by approximately 12%. Cimetidine also affects the body's uptake of rimantadine. Rimantadine can produce gastrointestinal and central nervous system adverse effects. Approximately 6% of patients (compared to 4% of patients taking a placebo) reported
Should Have Known Better shroud into a tender lyric about shoving aside his fear, discovering an oasis of perspective when he looks to his brother’s newborn daughter and sees his mother in her face. When he sings 'nothing can be changed,' he doesn’t sound resigned, but ready to look forward. It’s the dawn at the end of a long night, a prayer that past traumas might be healed by a beautiful present." Should Have Known Better "Should Have Known Better" is a song by American singer-songwriter and multi-instrumentalist Sufjan Stevens. It is the second track and second single from his seventh studio album, "Carrie