Glycogen branching enzyme leads to increased osmotic pressure resulting in cellular swelling and death. The tissues most affected by this disease are the liver, heart, and neuromuscular system, areas with the greatest levels of glycogen accumulation. Abnormal glycogen buildup in the liver interferes with liver functioning and can result in an enlarged liver and liver disease. In muscles, the inability of cells to efficiently breakdown glycogen due to the severe reduction or absence of branching can lead to muscle weakness and atrophy. At least three mutations in the GBE1 gene have been found to cause another disease called adult polyglucosan body disease (APBD).
The body in traditional Chinese medicine trunk, and ends under the collarbone. (2)The Bladder, a Yang organ, stores and removes fluid from the body by receiving Kidney chi. Imbalance of the Bladder leads to frequent or uncontrolled urination. The Bladder Meridian begins in the corner of the eye, moves down the back, and ends on the back of the knee. The Bladder also has another line, which starts alongside the previous line, moves down to the outer edge of the foot and ends on the small toe. The body in traditional Chinese medicine The model of the body in traditional Chinese medicine (TCM) has the following