Alpha thalassemia abnormal morphogenesis Alpha thalassemia abnormal morphogenesis Alpha Thalassemia-Abnormal Morphogensis is a group of blood disorders that affect the way the body makes hemoglobin. Hemoglobin is a protein found in red blood cells that carries oxygen throughout the body. It's made up of alpha globin and beta globin. Normally each person has four genes for alpha globin, Alpha thalassemia happens when one or more of the genes that control the making of alpha globin is absent or defective. It can cause anemia ranging from mild to severe. Also causing Genital abnormalities and terminal transverse limb defectiveness which is why it is called abnormal
Red blood cell synthesised by the kidney. Just before and after leaving the bone marrow, the developing cells are known as reticulocytes; these constitute about 1% of circulating red blood cells. The functional lifetime of a red blood cell is about 100–120 days, during which time the red blood cells are continually moved by the blood flow push (in arteries), pull (in veins) and a combination of the two as they squeeze through microvessels such as capillaries. They are also recycled in the bone marrow. The aging red blood cell undergoes changes in its plasma membrane, making it susceptible to selective recognition by