Tooth discoloration decomposed gradually and a blue-brown discoloration develops. Teeth may turn grey following trauma-induced pulp necrosis (death of the pulp). This discoloration typically develops weeks or months after the injury and is caused by incorporation of pigments released during the breakdown of the pulpal tissue and blood into the dentin. Yellow discoloration may occur following pulp canal obliteration, i.e., the sealing up of the pulp. Trauma to a developing adult tooth (e.g., intrusion of a baby tooth into the bone) may affect the enamel layer of the adult tooth. This becomes apparent when the adult tooth erupts into the mouth. Teeth
Development of the nervous system intellectual disability. The mammalian central nervous system (CNS) is derived from the ectoderm—the outermost tissue layer—of the embryo. In the third week of human development the neuroectoderm appears and forms the neural plate along the dorsal side of the embryo. The neural plate is the source of the majority of neurons and glial cells of the CNS. A groove forms along the long axis of the neural plate and, by week four of development, the neural plate wraps in on itself to give rise to the neural tube, which is filled with cerebrospinal fluid (CSF). As the embryo develops, the