Allergic inflammation immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema. The late phase of a Type 1 reaction (which develops 8–12
Body substance isolation known as body substance isolation. In 1996, both practices were replaced by the latest approach known as standard precautions (health care). Nowadays and in isolation, practice of body substance isolation has just historical significance. Body substance isolation went further than universal precautions in isolating workers from pathogens, including substances now currently known to carry HIV. These pathogens fall into two broad categories, bloodborne (carried in the body fluids) and airborne. The practice of BSI was common in Pre-Hospital care and emergency medical services due to the often unknown nature of the patient and his/her disease or medical conditions. It was