Endocrine gland atrophy, or active destruction. Hyperfunction can occur as a result of hypersecretion, loss of suppression, hyperplastic or neoplastic change, or hyperstimulation. Endocrinopathies are classified as primary, secondary, or tertiary. Primary endocrine disease inhibits the action of downstream glands. Secondary endocrine disease is indicative of a problem with the pituitary gland. Tertiary endocrine disease is associated with dysfunction of the hypothalamus and its releasing hormones. As the thyroid, and hormones have been implicated in signaling distant tissues to proliferate, for example, the estrogen receptor has been shown to be involved in certain breast cancers. Endocrine, paracrine, and autocrine signaling have all
Gastric glands neck cells" that produce mucus. This is thought to be different from the mucus produced by the gastric mucosa. Fundic glands found in the fundus and also in the body have another two cell types–gastric chief cells and parietal cells (oxyntic)). The chief cells are found in the basal regions of the gland and release a zymogen – pepsinogen, a precursor to pepsin. The parietal cells ("parietal" means "relating to a wall") are found in the walls of the tubes. The parietal cells secrete hydrochloric acid–the main component of gastric acid. This needs to be readily available for the stomach