Versican other inflammatory cells) can migrate more easily through extracellular matrix that has a higher versican content. Deposits of versican are not present in normal skin but are found in the reticular dermis during keloid scarring, a condition where scar formation becomes uncontrolled and overgrowth of skin tissue occurs at the site of the wound. Versican has been shown to interact with hyaluronan and a link protein (hyaluronan and proteoglycan link protein 1; HAPLN1). Versican Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the "VCAN" gene. Versican is a
The Scar of Shame The Scar of Shame The Scar of Shame is a silent film, which was filmed in 1926 and released in 1927. It was produced by the Colored Players Film Corporation of Philadelphia, in one of the earlier examples of race movies, in which an entirely black cast performed a feature film specifically for a black audience. The film was produced and written by David Starkman and was directed by Frank Peregini, both white. "The Scar of Shame" was a black silent melodrama with black actors written for a predominantly black audience. Melodramas were the genre of choice for early 20th