Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
What Strong Fences Make What Strong Fences Make What Strong Fences Make is a 2009 play by Israel Horovitz. Horovitz told an interviewer that he wrote "What Strong Fences Make" because "another voice needed to be heard" in the wake of Caryl Churchill's play "Seven Jewish Children", which he argues "offensive, distorted and manipulative". Horovitz has offered to allow any theater that wishes to produce "What Strong Fences Make" free of royalties, provided that a collection is taken up following all performances for the benefit of ONE Family Fund, a charity that assists children wounded in attacks on Israel. The playwright has made the