Glipizide 10 milligrams. Glipizide sensitizes the beta cells of pancreatic islets of Langerhans insulin response, meaning that more insulin is released in response to glucose than would be without glipizide ingestion. Glipizide acts by partially blocking potassium channels among beta cells of pancreatic islets of Langerhans. By blocking potassium channels, the cell depolarizes, which results in the opening of voltage-gated calcium channels. The resulting calcium influx encourages insulin release from beta cells. Glipizide Glipizide is an oral rapid- and short-acting anti-diabetic medication from the sulfonylurea class. It is classified as a second-generation sulfonylurea, which means that it undergoes enterohepatic circulation. Second-generation
Ryan Langerhans going a combined 0-for-4 with a walk and an error. On May 2, 2007, he was traded to the Washington Nationals for Chris Snelling. On June 28, he was traded to the Seattle Mariners for utility player Mike Morse. With the Mariners, Langerhans had better results hitting curve balls and sliders than fastballs and changeups, causing some speculation that this skill set could be responsible for his tendency to play in a part-time role. He was non-tendered at the deadline to offer arbitration on December 12, 2009. On December 18, however, the Mariners re-signed Langerhans to a minor league contract.