Insulin oscillation oscillations. The insulin oscillations are generated by pulsatile release of the hormone from the pancreas. Insulin originates from beta cells located in the islets of Langerhans. Since each islet contains up to 2000 beta cells and there are one million islets in the pancreas it is apparent that pulsatile secretion requires sophisticated synchronization both within and among the islets of Langerhans. Pulsatile insulin secretion from individual beta cells is driven by oscillation of the calcium concentration in the cells. In beta cells lacking contact, the periodicity of these oscillations is rather variable (2-10 min). However, within an islet of Langerhans
Ryan Langerhans going a combined 0-for-4 with a walk and an error. On May 2, 2007, he was traded to the Washington Nationals for Chris Snelling. On June 28, he was traded to the Seattle Mariners for utility player Mike Morse. With the Mariners, Langerhans had better results hitting curve balls and sliders than fastballs and changeups, causing some speculation that this skill set could be responsible for his tendency to play in a part-time role. He was non-tendered at the deadline to offer arbitration on December 12, 2009. On December 18, however, the Mariners re-signed Langerhans to a minor league contract.