Tendon induce endothelial cell proliferation and migration, and VEGF mRNA has been shown to be expressed at the site of tendon injuries along with collagen I mRNA. Bone morphogenetic proteins (BMPs) are a subgroup of TGF-β superfamily that can induce bone and cartilage formation as well as tissue differentiation, and BMP-12 specifically has been shown to influence formation and differentiation of tendon tissue and to promote fibrogenesis. In animal models, extensive studies have been conducted to investigate the effects of mechanical strain in the form of activity level on tendon injury and healing. While stretching can disrupt healing during the initial
Quadriceps tendon rupture year. Quadriceps tendon rupture A quadriceps tendon rupture is a tear of the tendon that runs from the quadriceps muscle to the top of the knee cap. Symptoms are pain and the inability to extend the knee against resistance. A gap can often be palpated at the tendon's normal location. The diagnosis is usually made clinically, but ultrasound or MRI can be used if there is any doubt. The tendon can be surgically repaired. Afterwards a brace is given that prevents flexion of the knee. Athletes who have suffered this injury generally return to action in about 9 months to