Estradiol for tissue of the reproductive organs, supporting the lining of the vagina, the cervical glands, the endometrium, and the lining of the fallopian tubes. It enhances growth of the myometrium. Estradiol appears necessary to maintain oocytes in the ovary. During the menstrual cycle, estradiol produced by the growing follicles triggers, via a positive feedback system, the hypothalamic-pituitary events that lead to the luteinizing hormone surge, inducing ovulation. In the luteal phase, estradiol, in conjunction with progesterone, prepares the endometrium for implantation. During pregnancy, estradiol increases due to placental production. The effect of estradiol, together with estrone and estriol, in pregnancy
Menstrual disorder Menstrual disorder A menstrual disorder is an abnormal condition in a woman's menstrual cycle. Disorders of ovulation include oligoovulation and anovulation: "Polymenorrhea" is the medical term for cycles with intervals of 21 days or fewer. "Irregular menstruation" is where there is variation in menstrual cycle length of more than approximately eight days for a woman. The term "metrorrhagia" is often used for irregular menstruation that occurs between the expected menstrual periods. "Oligomenorrhea" is the medical term for infrequent, often light menstrual periods (intervals exceeding 35 days). "Amenorrhea" is the absence of a menstrual period in a woman of reproductive age.