Hypertensive kidney disease this situation, the kidney supplied blood by the narrowed renal artery suffers from inadequate blood flow, which in turn causes the size of the kidneys to decrease. Other consequences include arterial stiffening, which involves a gradual breakdown of elastic fibers and intima (the innermost layer of a blood vessel) thickening. An alternative mechanism of hypertensive nephropathy is prolonged glomerular hypertension and hence glomerular hyperfiltration. These can occur simultaneously but not necessarily. The idea is that hypertension results in sclerosis of the glomeruli which ultimately means reduced kidney function. As a compensatory mechanism, the unaffected nephrons (specifically, the preglomerular arterioles) vasodilate
Left anterior descending artery the right aortic sinus. In 78% of cases, it reaches the apex of the heart. The LAD gives off two types of branches: "septals" and "diagonals". The artery supplies the anterolateral myocardium, apex, and interventricular septum. The LAD typically supplies 45-55% of the left ventricle (LV) and is therefore considered the most critical vessel in terms of myocardial blood supply. The "widow maker" is an alternate name for the anterior interventricular branch of the left coronary artery. The name "widow maker" may also apply to the left coronary artery or severe occlusions to that artery. This term is used because