Nav1.5 kb. The gene consists of 28 exons, of which exon 1 and in part exon 2 form the 5’ untranslated region (5’UTR) and exon 28 the 3’ untranslated region (3’UTR) of the RNA. SCN5A is part of a family of 10 genes that encode different types of sodium channels, i.e. brain-type (Na1.1, Na1.2, Na1.3, Na1.6), neuronal channels (Na1.7, Na1.8 and Na1.9), skeletal muscle channels (Na1.4) and the cardiac sodium channel Na1.5. SCN5A is mainly expressed in the heart, where expression is abundant in working myocardium and conduction tissue. In contrast, expression is low in the sinoatrial node and atrioventricular node.
Node-to-node data transfer Node-to-node data transfer In telecommunications, node-to-node data transfer is the movement of data from one node of a network to the next. In the OSI model it is handled by the lowest two layers, the data link layer and the physical layer. In most communication systems, the transmitting point applies source coding, followed by channel coding, and lastly, line coding. This produces the baseband signal. The presence of filters may perform pulse shaping. Some systems then use modulation to multiplex many baseband signals into a broadband signal. The receiver un-does these transformations in reverse order: demodulation, trellis decoding, error detection