Versican other inflammatory cells) can migrate more easily through extracellular matrix that has a higher versican content. Deposits of versican are not present in normal skin but are found in the reticular dermis during keloid scarring, a condition where scar formation becomes uncontrolled and overgrowth of skin tissue occurs at the site of the wound. Versican has been shown to interact with hyaluronan and a link protein (hyaluronan and proteoglycan link protein 1; HAPLN1). Versican Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the "VCAN" gene. Versican is a
Inflammatory papillary hyperplasia Inflammatory papillary hyperplasia Inflammatory papillary hyperplasia is a hyperplasia (overgrowth) of soft tissue, usually beneath a denture. It is associated with poor denture hygiene, denture overuse, and ill-fitting dentures. It is a closely related condition to inflammatory fibrous hyperplasia (epulis fissuratum), but the appearance and location differs. It appears as an asymptomatic erythematous area, usually on the hard palate, with a pebbly surface. The exact cause of inflammatory papillary hyperplasia is unknown, but it is thought to be a reactive, inflammatory lesion in response to irritation from an upper dental prosthesis. Nonetheless, it may also occur on the hard palates