Apparent mineralocorticoid excess syndrome cases recorded worldwide. Liquorice consumption may also cause a temporary form of AME due to its ability to block 11β-hydroxysteroid dehydrogenase type 2, in turn causing increased levels of cortisol. Cessation of licorice consumption will reverse this form of AME. Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In
Water organ of the article on the pipe organ, the ancient hydraulis was played by hand, not automatically by the water-flow; the keys were balanced and could be played with a light touch, as is clear from the reference in a Latin poem by Claudian (late 4th century), who uses this very phrase ("magna levi detrudens murmura tactu . . . intonet", “let him thunder forth as he presses out mighty roarings with a light touch”) ("Paneg. Manlio Theodoro," 320–22). Typically, water is supplied from some height above the instrument through a pipe, and air is introduced into the water stream by