Nav1.5 kb. The gene consists of 28 exons, of which exon 1 and in part exon 2 form the 5’ untranslated region (5’UTR) and exon 28 the 3’ untranslated region (3’UTR) of the RNA. SCN5A is part of a family of 10 genes that encode different types of sodium channels, i.e. brain-type (Na1.1, Na1.2, Na1.3, Na1.6), neuronal channels (Na1.7, Na1.8 and Na1.9), skeletal muscle channels (Na1.4) and the cardiac sodium channel Na1.5. SCN5A is mainly expressed in the heart, where expression is abundant in working myocardium and conduction tissue. In contrast, expression is low in the sinoatrial node and atrioventricular node.
Node influence metric probabilities. The accessibility has been shown to reveal community structure in urban networks, corresponds to the number of nodes which can be visited in a defined time period, and is predictive of the outcome of epidemiological SIR model spreading processes on networks with large diameter and low density. The expected force measures node influence from an epidemiological perspective. It is the expected value of the force of infection generated by the node after two transmissions. The expected force of a node formula_4 is given by where the sum is taken over the set formula_9 of all possible transmission clusters resulting