Protein signalling in heart development Protein signalling in heart development The heart is the first functional organ in a vertebrate embryo. There are 5 stages to heart development. Specification of cardiac precursor cells: The lateral plate mesoderm delaminates to form two layers: the dorsal somatic (parietal) mesoderm and the ventral splanchnic (visceral) mesoderm. The heart precursor cells come from the two regions of the splanchnic mesoderm called the cardiogenic mesoderm. These cells can differentiate into endocardium which lines the heart chamber and valves and the myocardium which forms the musculature of the ventricles and the atria. The heart cells are specified in anterior mesoderm by
How Many Licks? Lawrence and features the singer as a sex doll in three sexual fantasies. Sisqó did not appear in the video due to conflicts with his record label, Def Jam. Although music critics praised the visual, its treatment of sexuality elicited varied opinions from academics. It was also compared to music videos by other artists, including Minaj's 2011 single "Stupid Hoe" and American rapper Missy Elliott's 1997 single "The Rain (Supa Dupa Fly)". In addition to the clip, Lil' Kim promoted "How Many Licks?" with live performances. Mario Winans and Sean Combs produced "How Many Licks?" and wrote it with Lil'