Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
What Alice Found What Alice Found What Alice Found is a Sundance award-winning feature film released in U.S. theaters in 2003/2004 and for U.S. home video in 2004. It has aired on the Sundance Channel, Lifetime Movie Network, IFC, Canal Plus in France and ABC affiliates across the U.S. The independently made film was the second feature film for writer/director A. Dean Bell. The film is a harrowing coming of age tale about a young woman who flees her poor New Hampshire hometown life to follow her wealthier and socially accepted friend down to college life in Florida. But her car breaks down