Hypothalamic–pituitary–somatotropic axis with growth hormone deficiency or Laron syndrome ( insensitivity) show symptoms like short stature, dwarfism and obesity, but are also protected from some forms of cancer. Conversely, acromegaly and gigantism are conditions of GH and IGF-1 excess usually due to a pituitary tumor, and are characterized by overgrowth and tall stature. Hypothalamic–pituitary–somatotropic axis The hypothalamic–pituitary–somatotropic axis (HPS axis), or hypothalamic–pituitary–somatic axis, also known as the hypothalamic–pituitary–growth axis, is a hypothalamic–pituitary axis which includes the secretion of growth hormone (GH; somatotropin) from the somatotropes of the pituitary gland into the circulation and the subsequent stimulation of insulin-like growth factor 1 (IGF-1;
Anterior pituitary anterior pituitary contains five types of endocrine cell, and they are defined by the hormones they secrete: somatotropes (GH); Lactotropes (PRL); gonadotropes (LH and FSH); corticotropes (ACTH) and thyrotropes (TSH). It also contains non-endocrine folliculostellate cells which are thought to stimulate and support the endocrine cell populations. Hormones secreted by the anterior pituitary are trophic hormones (Greek: trophe, “nourishment”) and tropic hormones. "Trophic hormones" directly affect growth either as hyperplasia or hypertrophy on the tissue it is stimulating. "Tropic hormones" are named for their ability to act directly on target tissues or other endocrine glands to release hormones, causing numerous