Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Blood in the Water (book) in the Water" was a National Book Award Finalist in 2016, as well as a "New York Times" Most Notable Book, "Publishers Weekly" Top 10 Book of 2016, and received starred reviews at "Kirkus Reviews", "Publishers Weekly", and "Library Journal". Blood in the Water (book) Blood in the Water: The Attica Prison Uprising of 1971 and Its Legacy is the third book from University of Michigan historian Heather Ann Thompson. It provides the first complete history of the Attica Prison uprising of 1971 and details not only the events of the week-long uprising and its brutal ending, but also the