Pharmacokinetics of progesterone a few other countries under the brand name Progestasert. It was marketed between 1976 and 2001. The IUD was never widely used due to a relatively high contraceptive failure rate of 2.9% and the requirement of annual replacement. It contained 38 mg progesterone and released 65 μg progesterone into the uterus per day (adding up to about 35 mg after one year). For comparison, a woman's body produces on average about 25 mg progesterone per day during the luteal phase. While effective as a form of contraception and for decreasing menstrual bleeding and discomfort, long-lived IUDs can fundamentally only deliver
Menstrual disorder Menstrual disorder A menstrual disorder is an abnormal condition in a woman's menstrual cycle. Disorders of ovulation include oligoovulation and anovulation: "Polymenorrhea" is the medical term for cycles with intervals of 21 days or fewer. "Irregular menstruation" is where there is variation in menstrual cycle length of more than approximately eight days for a woman. The term "metrorrhagia" is often used for irregular menstruation that occurs between the expected menstrual periods. "Oligomenorrhea" is the medical term for infrequent, often light menstrual periods (intervals exceeding 35 days). "Amenorrhea" is the absence of a menstrual period in a woman of reproductive age.