Glycogen synthase expression of the muscle isozyme and not the liver isozyme. However, muscle-specific glycogen synthase activation may lead to excessive accumulation of glycogen, leading to damage in the heart and central nervous system following ischemic insults. The reaction is highly regulated by allosteric effectors such as glucose-6-phosphate (activator) and by phosphorylation reactions (deactivating). Glucose-6-phosphate allosteric activating action allows glycogen synthase to operate as a glucose-6-phosphate sensor. The inactivating phosphorylation is triggered by the hormone glucagon, which is secreted by the pancreas in response to decreased blood glucose levels. The enzyme also cleaves the ester bond between the C1 position of glucose
Campbell's Stores 1858-59, Sands Directory lists the following at Campbell's Wharf: Campbell & Co; Sugar Company's stores; JC Dibbs & Co, commission agents and wharfingers; Robert Nash, storekeeper; WH Eldred, Capt, Chili Flour Co; Chilian Consulate - Consul, WH Eldred. In 1861, it shows: Campbell & Co; Colonial Sugar Refining Co, stores; Peruvian guano stores; George Lloyd & Co stores; Robey & Co's stores; George Lewis custom house officer; and WH Eldred, broker & general agent. In 1863, it shows: 4. Merry Willis and Co, merchants; 3. Henry Fisher & Son, sugar factors; 2. Brown & Co, merchants; 1. EM Sayers &