Multiple endocrine neoplasia type 1 ATR. The exact function of MEN1 and the protein, menin, produced by this gene is not known, but following the inheritance rules of the "two-hit hypothesis" indicates that it acts as a tumor suppressor. In a diagnostic workup individuals with a combination of endocrine neoplasias suggestive of the "MEN1 syndrome" are recommended to have a mutational analysis of the MEN1 gene if additional diagnostic criteria are sufficiently met, mainly including: Multiple endocrine neoplasia or MEN is part of a group of disorders that affect the body's network of hormone-producing glands (the endocrine system). Hormones are chemical messengers that travel through
Obesity and the environment trigger." The theory of environmental obesogens proposes a different causal facet to obesity – that lifetime exposure to xenobiotic chemicals may change the body's metabolic system. Chemical obesogens are molecules that do not properly regulate lipid metabolism in the body and could therefore promote obesity. Data is scarce, but some in-vitro studies have found this model could be an accurate predictor of future obesity. A study suggested that smoking before and during pregnancy, for example, increases the risk of obesity twofold in children of school age. Many chemicals that are known or suspected to be obesogens are endocrine disruptors. These