Endocrine gland in regulating hormone levels in the blood. The nervous system, acting through hypothalamic controls, can in certain cases override or modulate hormonal effects. Diseases of the endocrine glands are common, including conditions such as diabetes mellitus, thyroid disease, and obesity. Endocrine disease is characterized by irregulated hormone release (a productive pituitary adenoma), inappropriate response to signaling (hypothyroidism), lack of a gland (diabetes mellitus type 1, diminished erythropoiesis in chronic renal failure), or structural enlargement in a critical site such as the thyroid (toxic multinodular goitre). Hypofunction of endocrine glands can occur as a result of loss of reserve, hyposecretion, agenesis,
Endocrine disruptor and toddlers ingest more contaminated house dust than the adults they live with, and therefore have much higher levels of pollutants in their systems. Consumer goods are another potential source of exposure to endocrine disruptors. An analysis of the composition of 42 household cleaning and personal care products versus 43 "chemical free" products has been performed. The products contained 55 different chemical compounds: 50 were found in the 42 conventional samples representing 170 product types, while 41 were detected in 43 "chemical free" samples representing 39 product types. Parabens, a class of chemicals that has been associated with reproductive-tract issues,