Pituitary apoplexy is attached to the hypothalamus, a part of the brain, by a stalk that also contains the blood vessels that supply the gland. It is unclear why pituitary tumors are five times more likely to bleed than other tumors in the brain. There are various proposed mechanisms by which a tumor can increase the risk of either infarction (insufficient blood supply leading to tissue dysfunction) or hemorrhage. The pituitary gland normally derives its blood supply from vessels that pass through the hypothalamus, but tumors develop a blood supply from the nearby inferior hypophyseal artery that generates a higher blood pressure,
Pituitary stalk tract. It has been thought that the pituitary stalk may become compressed due to suprasellar tumors in the pars tuberalis region, and that the resulting compression may cause hyperprolactinemia. This phenomenon has been described as the stalk effect or pituitary stalk compression syndrome. However, at least one article suggests that the increase in prolactin in these cases may instead be caused by the tumor's secretion of preprotachykinin A-derived tachykinins, substance P, and/or neurokinin A. Damage to the pituitary stalk blocks the release of antidiuretic hormone, resulting in polydypsia (abusive water intake) and polyuria (excessive urination). Pituitary stalk The pituitary stalk