Tympanic membrane retraction become eroded. As skin cells die they form a barrier of dry protein called keratin. This layer of keratin is normally pushed out of the ear by migration of skin cells along the ear canal and is turned into wax. Clearance of keratin can be disrupted by tympanic membrane retraction so that keratin accumulates within the retraction pocket. When keratin becomes trapped deep inside the ear and cannot be cleaned out, it is known as cholesteatoma. Growth of bacteria in the trapped keratin causes smelly discharge from the ear and can spread to cause serious infection. Various strategies may be
Membrane stabilizing effect Membrane stabilizing effect Membrane stabilizing effects involve the inhibition or total abolishing of action potentials from being propagated across the membrane. This phenomenon is common in nerve tissues as they are the carrier of impulses from the periphery to the central nervous system. Membrane stabilization is the method through which local anesthetics work. They block the propagation of action potentials across nerve cells, thereby producing a nerve block. Some beta-blockers also possess what is referred to as membrane stabilizing activity (MSA). This effect is similar to the membrane stabilizing activity of sodium channel blockers that represent Class I antiarrhythmics. MSA