Endocrine system paracrine, and autocrine signaling have all been implicated in proliferation, one of the required steps of oncogenesis. Other common diseases that result from endocrine dysfunction include Addison's disease, Cushing's disease and Graves' disease. Cushing's disease and Addison's disease are pathologies involving the dysfunction of the adrenal gland. Dysfunction in the adrenal gland could be due to primary or secondary factors and can result in hypercortisolism or hypocortisolism . Cushing's disease is characterized by the hypersecretion of the adrenocorticotropic hormone (ACTH) due to a pituitary adenoma that ultimately causes endogenous hypercortisolism by stimulating the adrenal glands. Some clinical signs of Cushing's
GreenScreen for Safer Chemicals GreenScreen for Safer Chemicals The GreenScreen for Safer Chemicals is a transparent, open standard for assessing chemical hazard that supports alternatives assessment for toxics use reduction through identifying chemicals of concern and safer alternatives. It is used by researchers, product formulators and certifiers in a variety of industries, including building products, textiles, apparel, and consumer products. The GreenScreen prioritizes the avoidance of substances with a high hazard as a carcinogen, mutagen, reproductive toxicant or developmental toxicant or endocrine disruptor or that are a persistent, bioaccumulative and toxic substance (PBT). The GreenScreen protocol is published in a Guidance document that is