Glipizide 10 milligrams. Glipizide sensitizes the beta cells of pancreatic islets of Langerhans insulin response, meaning that more insulin is released in response to glucose than would be without glipizide ingestion. Glipizide acts by partially blocking potassium channels among beta cells of pancreatic islets of Langerhans. By blocking potassium channels, the cell depolarizes, which results in the opening of voltage-gated calcium channels. The resulting calcium influx encourages insulin release from beta cells. Glipizide Glipizide is an oral rapid- and short-acting anti-diabetic medication from the sulfonylurea class. It is classified as a second-generation sulfonylurea, which means that it undergoes enterohepatic circulation. Second-generation
Islets of Granada the islands and nearby peninsula. Islets of Granada The islets of Granada (Spanish: "Isletas de Granada") are located in Lake Nicaragua, just southeast of the city of Granada in Nicaragua. The islets are a group of 365 small islands scattered about the Asese peninsula. The islets are of volcanic origin, they were formed when the Mombacho volcano blew much of its cone into the lake thousands of years ago, thereby creating the archipelago. Most of the islets are covered with vegetation and rich with bird life. Many of the islets are occupied. Some are privately owned and hold homes or