Transgender hormone therapy (male-to-female) medical professional. Inducers of CYP3A4 and other cytochrome P450 enzymes can reduce the effects of MTF HRT. A variety of different sex-hormonal medications are used in feminizing hormone therapy for transgender women. These include estrogens to induce feminization and suppress testosterone levels; antiandrogens such as androgen receptor antagonists, antigonadotropins, GnRH modulators, and 5α-reductase inhibitors to further oppose the effects of androgens like testosterone; and progestogens for various possible though uncertain benefits. Estrogens are the major sex hormones in women, and are responsible for the development and maintenance of feminine secondary sexual characteristics, such as breasts, wide hips, and a feminine
Male lactation where male lactation occurs and it is not well understood what evolutionary factors control the development of this trait. The phenomenon of male lactation occurs in some species, notably the Dayak fruit bat ("Dyacopterus spadiceus"), and the lactating males may assist in the nursing of their infants. In addition, male goats are known to lactate on occasion. Human male breastfeeding is possible, but production of the hormone prolactin is necessary to induce lactation, so male lactation does not occur under normal conditions. Domperidone is a drug that can be used to increase lactation. Male lactation has also been seen during