Ventromedial nucleus of the hypothalamus the brain. VMH is also important in mammal play behaviour. Lesions to VMH along with the hippocampus, amygdala, the cerebellum, and the lateral hypothalamus are all linked to reduced play The VMHdm has a role in the male vocalizations and scent marking behaviors. The VMHvl plays a role in sexual behaviors in females (lordosis), thus stimulating their sexual arousal. Bilateral FOS expression in the VMH after repeated seizures is associated with alteration in the severity of flurothyl induced seizures in C57BL/6J mice that are not present in DBA/2J mice. Moreover, bilateral lesions of the VMH are able to block the
Antigen transfer in the thymus in thymic medulla, namely clonal deletion ("recessive tolerance") and T Regulatory cells selection ("dominant tolerance") which force autoreactive T cells to apoptosis or skew them into suppressor T regulatory cells (TRegs), respectively, in order to protect body against manifestations of autoimmunity. These processes are mediated especially by unique subset of stromal cells called Medullary thymic epithelial cells (mTECs) via presentation of Tissue restricted antigens (TRAs) that represent self tissues from almost all parts of the body. mTECs are not only capable to present TRAs as efficient APCs. They are also potent in production of these TRAs via unique process called