Red blood cell wide variety of endogenous mediators and xenobiotics. Excessive eryptosis is observed in red blood cells lacking the cGMP-dependent protein kinase type I or the AMP-activated protein kinase AMPK. Inhibitors of eryptosis include erythropoietin, nitric oxide, catecholamines and high concentrations of urea. Much of the resulting breakdown products are recirculated in the body. The heme constituent of hemoglobin are broken down into iron (Fe) and biliverdin. The biliverdin is reduced to bilirubin, which is released into the plasma and recirculated to the liver bound to albumin. The iron is released into the plasma to be recirculated by a carrier protein called
Blood cell were first observed by Gabriel Andral, a French professor of medicine, and William Addison, a British physician, simultaneously. Both men believed that both red and white cells were altered in disease. With these discoveries, hematology, a new field of medicine, was established. Even though agents for staining tissues and cells were available, almost no advances were made in knowledge about the morphology of blood cells until 1879, when Paul Ehrlich published his technique for staining blood films and his method for differential blood cell counting Blood cell A blood cell, also called a hematopoietic cell, hemocyte, or hematocyte, is a