Pacemaker current on hyperpolarization, and very slow kinetics. The funny current is highly expressed in spontaneously active cardiac regions, such as the sinoatrial node (SAN, the natural pacemaker region), the atrioventricular node (AVN) and the Purkinje fibres of conduction tissue. The funny current is a mixed sodium–potassium current that activates upon hyperpolarization at voltages in the diastolic range (normally from −60/−70 mV to −40 mV). When, at the end of a sinoatrial action potential, the membrane repolarizes below the I threshold (about −40/−50 mV), the funny current is activated and supplies inward current, which is responsible for starting the diastolic depolarization phase
Node deletion nodes are deleted compared to the random removal case. The diameter is doubled when 5% of the nodes are eliminated. This is because removing the hubs seriously changes the topology of the network, most links are removed, so the diameter goes up. Node deletion Node deletion is the procedure of removing a node from a network, where the node is either chosen randomly or directly. Node deletion is used to test the robustness and the attack tolerance of networks. Understanding how a network changes in response to node deletion is critical in many empirical networks. Application varies across many fields,