Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
The Foolish Old Man Removes the Mountains "Serve the People" and "Memory of Norman Bethune" (紀念白求恩), it was one of the three most-frequently read stories in the "Little Red Book" of Mao's sayings and was memorized by schoolchildren during the Cultural Revolution. The Foolish Old Man Removes the Mountains The Foolish Old Man Removes the Mountains () is a well-known fable from Chinese mythology about the virtues of perseverance and willpower. The tale first appeared in Book 5 of the "Liezi", a Daoist text of the 4th century BC, and was retold in the "Garden of Stories" by the Confucian scholar Liu Xiang in the 1st century