Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
What Alice Found on the highway under mysterious circumstances and a middle-aged "snowbird" couple in an RV come to her rescue, offering a ride all the way south. Before too long we're wondering if it wasn't the seemingly good Samaritans who sabotaged her car in the first place. "What Alice Found" is a complex story about mothers and daughters and the "haves and have-nots" in American society as Alice is turned into a truck stop prostitute. Critically acclaimed, "What Alice Found" was selected by "The New York Times"' Stephen Holden as a "Critic's Pick" and was praised by Kevin Thomas in the "Los