Allotropes of carbon dispersion of light of diamond make it useful for both industrial applications and jewelry. Diamond is the hardest known natural mineral. This makes it an excellent abrasive and makes it hold polish and luster extremely well. No known naturally occurring substance can cut (or even scratch) a diamond, except another diamond. The market for industrial-grade diamonds operates much differently from its gem-grade counterpart. Industrial diamonds are valued mostly for their hardness and heat conductivity, making many of the gemological characteristics of diamond, including clarity and color, mostly irrelevant. This helps explain why 80% of mined diamonds (equal to about 100
Substance P with inflammatory processes and pain. The original discovery of Substance P (SP) was in 1931 by Ulf von Euler and John H. Gaddum as a tissue extract that caused intestinal contraction "in vitro". Its tissue distribution and biologic actions were further investigated over the following decades. The eleven-amino-acid structure of the peptide was determined by Susan Leeman in 1971. In 1983, NKA (previously known as substance K or neuromedin L) was isolated from porcine spinal cord and was also found to stimulate intestinal contraction. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). It belongs to the