Gonadal dysgenesis If a single or combination of these genes are mutated or deleted, downstream signalling is disrupted, leading to malformation of male external genitalia. SRY acts on gene SOX9 which drives Sertoli cell formation and testis differentiation. An absence in SRY causes SOX9 to not be expressed at the appropriate time or concentration, leading to a deficiency in testosterone and Anti-Müllerian hormone production. Inadequate levels of testosterone and Anti-Müllerian hormone disrupts the development of Wolffian ducts and internal genitalia that are key to male reproductive tract development. The lack of the male associated steroid hormones drives Müllerian duct development and perusal
Causes of sexual violence male rapists had less empathy toward women who had been sexually assaulted by an unknown assailant and more hostility toward women than non-sex-offenders and nonoffender males/females. Meta-analyses indicate that convicted rapists demonstrate greater sexual arousal to scenes of sexual coercion involving force than do non-rapists. There is evidence to suggest that sexual violence is also a learned behavior in some adults, particularly as regards child sexual abuse. Studies on sexually abused boys have shown that around one in five continue in later life to molest children themselves. Such experiences may lead to a pattern of behavior where the man regularly