Nucleated red blood cell in the normal development of a normoblast. A megaloblast is an unusually large erythroblast that can be associated with vitamin B deficiency (caused by pernicious anemia or dietary insufficiency), folic acid deficiency, or both (such anemias are collectively called megaloblastic anemias). This kind of anemia leads to macrocytes (abnormally large red cells) and the condition called macrocytosis. The cause of this cellular gigantism is an impairment in DNA replication that delays nuclear maturation and cell division. Because RNA and cytoplasmic elements are synthesized at a constant rate despite the cells' impaired DNA synthesis, the cells show nuclear-cytoplasmic asynchrony. NRB's can
Blood red wound, and it does not change color upon exposure to air. The color "blood red", therefore, covers both these states: the darker deoxygenated color and the brighter oxygenated one. Also, dried blood often has a darker, rust-colored quality: all dried blood has been oxygenated and then desiccated, causing the cells within it to die. This blood is often darker than either shade of red that can be seen in fresh blood. In the RGB color spectrum blood red often consists only of the color red, with no green or blue component; in the CYMK color model blood red has no