Gene therapy of the human retina levels of light. What follows often is the death of cone cells, responsible for color vision and acuity, at light levels present during the day. Loss of cones leads to full blindness as early as five years old, but may not onset until many years later. There have been multiple hypotheses about how the lack of rod cells can lead to the death of cone cells. Pinpointing a mechanism for RP is difficult because there are more than 39 genetic loci and genes correlated with this disease. In an effort to find the cause of RP, there have been different
Giant retinal ganglion cells an S-Off, (L + M)-On opponency. Their spatial modulation transfer function is low-pass, with an upper limit of about 0.6 cycles per degree. Dacey "et al". propose that the giants subserve the subconscious, 'non-image-forming' functions of circadian photoentrainment and pupillary diameter, and via the rod and cone inputs, may help mediate conscious perception of irradiance. Giant retinal ganglion cells Giant retinal ganglion cells are photosensitive ganglion cells with large dendritic trees discovered in the human and macaque retina by Dacey "et al". (2005). Giant retinal ganglion cells contain a photo-pigment, melanopsin, allowing them to respond directly to light. They also