Light skin of UVA can penetrate deeply into the dermis in persons with light skin pigmentation with little protective melanin pigment. The characteristic of fair skin, red hair, and freckling is associated with high amount of pheomelanin, little amounts of eumelanin. This phenotype is caused by a loss-of-function mutation in the melanocortin 1 receptor (MC1R) gene. However, variations in the MC1R gene sequence only have considerable influence on pigmentation in populations where red hair and extremely fair skin is prevalent. The gene variation’s primary effect is to promote eumelanin synthesis at the expense of pheomelanin synthesis, although this contributes to very little
Minium (pigment) 300 B.C. It was known in the Han Dynasty (200 BC-200 AD) under the name "cinnabar of lead" ("ch'ien tan"), The process of manufacturing it was described in a Chinese manuscript of the 5th century. Minium was widely used for Persian miniature painting and Indian miniature painting. Minium (pigment) Minium, also known as red lead, is a bright orange red pigment that was widely used in the Middle Ages for the decoration of manuscripts and for painting. It was made by roasting white lead pigment in the air; the white lead would gradually turn yellow, then into an orange lead