Hyaline layer of Hopewell-Smith derivative proteins, such as Emdogain, in trying to stimulate reproduction of cementum in periodontal bony defects is based on the presence of enamel matrix-like proteins within the hyaline layer. Hyaline layer of Hopewell-Smith In tooth development, the hyaline layer of Hopewell-Smith is the most peripheral layer of initially unmineralized dentin that forms immediately subjacent to the cementodentinal junction (CDJ). It eventually mineralizes, but not before the rest of the dentin is already mineralized. It is 0.5-0.8 µm thick and contains enamel matrix-like protein as well as the proteins one would expect to find in dentin. It is into this hyaline
Human tooth development rapidly. This results in the perpetually increasing size of the junctional epithelial layer and the isolation of the remnants of ameloblasts from any source of nutrition. As the ameloblasts degenerate, a gingival sulcus is created. Frequently, nerves and blood vessels run parallel to each other in the body, and the formation of both usually takes place simultaneously and in a similar fashion. However, this is not the case for nerves and blood vessels around the tooth, because of different rates of development. Nerve fibers start to near the tooth during the cap stage of tooth development and grow toward the