Willow active extract of the bark, called salicin, was isolated to its crystalline form in 1828 by Henri Leroux, a French pharmacist, and Raffaele Piria, an Italian chemist, who then succeeded in separating out the compound in its pure state. In 1897, Felix Hoffmann created a synthetically altered version of salicin (in his case derived from the "Spiraea" plant), which caused less digestive upset than pure salicylic acid. The new drug, formally acetylsalicylic acid, was named Aspirin by Hoffmann's employer Bayer AG. This gave rise to the hugely important class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). Some of humans'
U Should've Known Better song entered the "Billboard" Hot 100 chart, where it debuted at number 67 in the week of June 6, 2004, the second-highest debut of the week. "U Should've Known Better" remained twenty weeks on the chart, reaching its peak position of number 19 in its ninth week. It marked the second single from "After the Storm" to reach the top twenty on the Hot 100chart and, as the album's final single, would remain its second highest-charting offering behind leading single "So Gone." Although never released on a CD single or CD maxi single format, "U Should've Known Better" was also