Legionnaires' disease Although the risk of Legionnaires' disease being spread by large-scale water systems cannot be eliminated, it can be greatly reduced by writing and enforcing a highly detailed, systematic water safety plan appropriate for the specific facility involved (office building, hospital, hotel, spa, cruise ship, etc.) Some of the elements that such a plan may include are: An effective water safety plan also covers such matters as training, record-keeping, communication among staff, contingency plans, and management responsibilities. The format and content of the plan may be prescribed by public health laws or regulations. Effective antibiotics include most macrolides, tetracyclines, ketolides, and
Rare disease assumption odds ratio (OR) is equal to 16 and the relative risk (RR) is equal to 8.65. Although the prevalence in our example equals 10% it is very difficult to apply the rare disease assumption because OR and RR can hardly be considered to be approximately the same. However, in this example the disease is not particularly "rare"; a 10% prevalence value means 1 in 10 people would have it. As the prevalence drops lower and lower, OR approaches the RR much more closely. This is one of the most problematic aspects of the rare disease assumption, since there is no