Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Survivor: Blood vs. Water Survivor: Blood vs. Water Survivor: Blood vs. Water is the 27th season of the American CBS competitive reality television series "Survivor". The season filmed in May–June 2013 and premiered on Wednesday, September 18, 2013, featuring returning castaways and their loved ones competing against each other. It was the third consecutive season, and the ninth season overall, to feature returning contestants. As with the previous two seasons, the season was filmed in the Philippines, but this time at Palaui Island, Cagayan. The tribe names were Galang and Tadhana, which means "respect" and "destiny", respectively, in Tagalog. Tyson Apostol was named the