Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
The Water & the Blood deep lyrics that give the listener something more than a series of clichés to grasp at" with regards to this album's songs. At New Release Tuesday, Mary Nikkel wrote that "Although musically this album does not set itself too far apart from other recent indie-leaning worship projects, the thoughtful lyrics and joyful spirit make this an album well worth an attentive listen." Jonathan Kemp at The Christian Music Review Blog told that release "features possibly the most theologically sound and theologically deep lyrics" that he has listened to in quite sometime. "The Water & the Blood" garnered critical acclaim from