Endocrine gland been implicated in proliferation, one of the required steps of oncogenesis. Other common diseases that result from endocrine dysfunction include Addison’s disease, Cushing’s disease and Grave’s disease. Cushing's disease and Addison's disease are pathologies involving the dysfunction of the adrenal gland. Dysfunction in the adrenal gland could be due to primary or secondary factors and can result in hypercortisolism or hypocortisolism . Cushing’s disease is characterized by the hypersecretion of the adrenocorticotropic hormone (ACTH) due to a pituitary adenoma that ultimately causes endogenous hypercortisolism by stimulating the adrenal glands. Some clinical signs of Cushing’s disease include obesity, moon face, and
Multiple endocrine neoplasia mutation or hereditary transmission. The presence of two or more tumor types in a single patient does not automatically designate that individual as having MEN because there is a small statistical chance that development of two "sporadic" tumors that occur in one of the MEN syndromes could occur by chance. The term "multiple endocrine neoplasia" was introduced in 1968, but descriptions of the condition date back to 1903. Multiple endocrine neoplasia The term multiple endocrine neoplasia (MEN) encompasses several distinct syndromes featuring tumors of endocrine glands, each with its own characteristic pattern. In some cases, the tumors are malignant, in