Allergic inflammation immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema. The late phase of a Type 1 reaction (which develops 8–12
National Pollen and Aerobiology Research Unit £7m. It is situated in the west of Worcester, off the A443 and north of the Three Choirs Way. National Pollen and Aerobiology Research Unit The National Pollen and Aerobiology Research Unit or NPARU is a research institute in Worcester. It produces the UK's pollen count, and was the world's first pollen forecasting service. Aerobiology is the study of organic particles and organisms in the atmosphere. The National Pollen and Hayfever Bureau was founded in Norwich on 21 April 1983. Forecasts for Britain's six million sufferers of hay fever (allergic rhinitis) began from 1 June 1983; it was funded by