Molecular models of DNA simulations that are very important to understand how DNA functions "in vivo". From the very early stages of structural studies of DNA by X-ray diffraction and biochemical means, molecular models such as the Watson-Crick nucleic acid double helix model were successfully employed to solve the 'puzzle' of DNA structure, and also find how the latter relates to its key functions in living cells. The first high quality X-ray diffraction patterns of A-DNA were reported by Rosalind Franklin and Raymond Gosling in 1953. Rosalind Franklin made the critical observation that DNA exists in two distinct forms, A and B, and produced
Rosalind Franklin and DNA was a general consensus at the time that they were at the inside); and the other is that DNA exists in two forms, a crystalline (dry form) A-DNA and a hydrated (wet form) B-DNA. With her PhD student Raymond Gosling, she produced a series of X-ray images of DNA. The photograph (number 51, hence, popularised as Photo 51) of B-DNA taken in May 1952 was especially crucial. X-ray crystallography did not immediately show the precise helical structure. Franklin chose to work on A-DNA, while B-DNA was given to Maurice Wilkins. By the early 1953, Franklin was aware that both A