Nonsteroidal anti-inflammatory drug more effective than salicin and, in addition to its fever-reducing properties, is anti-inflammatory and analgesic. In 1869, Hermann Kolbe synthesised salicylate, although it was too acidic for the gastric mucosa. The reaction used to synthesise aromatic acid from a phenol in the presence of CO2 is known as the Kolbe-Schmitt reaction. By 1897 the German chemist Felix Hoffmann and the Bayer company prompted a new age of pharmacology by converting salicylic acid into acetylsalicylic acid—named aspirin by Heinrich Dreser. Other NSAIDs were developed from the 1950s forward. In 2001, NSAIDs accounted for 70,000,000 prescriptions and 30 billion over-the-counter doses sold
Should Have Known Better Should Have Known Better "Should Have Known Better" is a song by American singer-songwriter and multi-instrumentalist Sufjan Stevens. It is the second track and second single from his seventh studio album, "Carrie & Lowell", and was released digitally on March 11, 2015 on Asthmatic Kitty. A promotional CD was later released on Asthmatic Kitty but was not available for sale. ""Should Have Known Better"" received very positive reviews from contemporary music critics. The song was chosen upon release as Pitchfork Media's "Best New Track". Jeremy Gordon stated that, " 'Should Have Known Better' takes us back to the beginning he