Grey in the core of each hair. Melanin is also responsible for the color of the skin and of the eyes. There are only two types of pigment: dark (eumelanin) or light (phaeomelanin). Combined in various combinations, these pigments create all natural hair colors. Melanin itself is the product of a specialized cell, the melanocyte, which is found in each hair follicle, from which the hair grows. As hair grows, the melanocyte injects melanin into the hair cells, which contain the protein keratin and which makes up our hair, skin, and nails. As long as the melanocytes continue injecting melanin into
Hair cell mice bred to be missing the gene grow more hair cells than control mice that have the gene. Additionally, the sonic hedgehog protein has been shown to block activity of the retinoblastoma protein, thereby inducing cell cycle re-entry and the regrowth of new cells. The cell cycle inhibitor p27kip1 (CDKN1B) has also been found to encourage regrowth of cochlear hair cells in mice following genetic deletion or knock down with siRNA targeting p27. Research on hair cell regeneration may bring us closer to clinical treatment for human hearing loss caused by hair cell damage or death. Hair cell Hair cells