Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
Inelastic scattering it strikes and its neutron cross section. In inelastic scattering, the neutron interacts with the nucleus and the kinetic energy of the system is changed. This often activates the nucleus, putting it into an excited, unstable, short-lived energy state which causes it to quickly emit some kind of radiation to bring it back down to a stable or ground state. Alpha, beta, gamma, and protons may be emitted. Particles scattered in this type of nuclear reaction may cause the nucleus to recoil in the other direction. Inelastic scattering is common in molecular collisions. Any collision which leads to a chemical