Antibiotic penicillin led to renewed interest in the search for antibiotic compounds with similar efficacy and safety. For their successful development of penicillin, which Fleming had accidentally discovered but could not develop himself, as a therapeutic drug, Chain and Florey shared the 1945 Nobel Prize in Medicine with Fleming. Florey credited Rene Dubos with pioneering the approach of deliberately and systematically searching for antibacterial compounds, which had led to the discovery of gramicidin and had revived Florey's research in penicillin. In 1939, coinciding with the start of World War II, Dubos had reported the discovery of the first naturally derived antibiotic,
Dental antibiotic prophylaxis conditions for which clinicians recommended antibiotic prophylaxis, although there is no evidence to support this practice. These conditions include renal dialysis shunt, cerebrospinal fluid shunt, vascular graft, immunosuppression secondary to cancer and cancer chemotherapy, systemic lupus erythematosus, and type 1 diabetes mellitus. It is of importance to dental patients and practitioners to remain current with regards to the latest recommendations rendered by professional governing bodies such as the American Dental Association (ADA), American Heart Association (AHA) and the American Association of Orthopaedic surgeons (AAOS). Antibiotic prophylaxis is intended to avoid adverse outcomes in certain patients at "highest risk of postoperative