Grünenthal prohibited the research and manufacture of penicillin by German companies. When the ban was lifted, Grünenthal was the first company to introduce penicillin in the postwar period into the German market. This investment achieved a big financial boost for the company. Chemie Grünenthal synthesized thalidomide in 1954 and acquired a 20-year patent. Soon after obtaining a patent in April 1954, the company started clinical trials, and as early as November 1956, marketed the drug for the treatment of respiratory infections under the trade name Grippex, a combination drug that contained thalidomide, quinine, vitamin C, phenacetin, and acetylsalicylic acid. Researchers at
U Should've Known Better Me" was shelved, the song was one out of five original records that were transferred into its new version, "After the Storm". Although a duet with DMX, "Don't Gotta Go Home", was expected be released as the album's fourth single at times, "U Should've Known Better" eventually replaced original plans. Released as the album's fourth and final single in March 2004, "U Should've Known Better" opened as the Hot Shot Debut of the week at number 72 on "Billboard"s Hot R&B/Hip-Hop Singles & Tracks chart in the week of April 3, 2004. However, it took another three months until the