Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
Conjoint tendon A weakening of the conjoint tendon can precipitate a direct inguinal hernia. A direct inguinal hernia will protrude through Hesselbach's triangle, whose borders are the rectus abdominis (medially), inferior epigastric artery and vein (superolaterally), and the inguinal ligament (inferiorly). The hernia will lie medial to the inferior epigastric artery. This is in contrast to an indirect inguinal hernia, which will protrude laterally to the inferior epigastric artery and is most commonly due to an embryological defect in the closure of the deep inguinal ring. Conjoint tendon The conjoint tendon (previously known as the inguinal aponeurotic falx) is a structure formed