Eardrum the membrane as far as its center, drawing it toward the tympanic cavity. The lateral surface of the membrane is thus concave. The most depressed aspect of this concavity is termed the umbo (). Sensory innervation of the external surface of the tympanic membrane is supplied mainly by the auriculotemporal nerve, a branch of the mandibular nerve (cranial nerve V), with contributions from the auricular branch of the vagus nerve (cranial nerve X), the facial nerve (cranial nerve VII), and possibly the glossopharyngeal nerve (cranial nerve IX). The inner surface of the tympanic membrane is innervated by the glossopharyngeal nerve.
Integral membrane protein at atomic resolution by X-ray crystallography or nuclear magnetic resonance spectroscopy. They are challenging subjects for study owing to the difficulties associated with extraction and crystallization. In addition, structures of many water-soluble protein domains of IMPs are available in the Protein Data Bank. Their membrane-anchoring α-helices have been removed to facilitate the extraction and crystallization. Search integral membrane proteins in the PDB (based on gene ontology classification) IMPs can be divided into two groups: The most common type of IMP is the transmembrane protein (TM), which spans the entire biological membrane. Single-pass membrane proteins cross the membrane only once, while