Point mutation high altitude, for example), the absence of a polar amino acid at position six of the β-globin chain promotes the non-covalent polymerisation (aggregation) of hemoglobin, which distorts red blood cells into a sickle shape and decreases their elasticity. Hemoglobin is a protein found in red blood cells, and is responsible for the transportation of oxygen through the body. There are two subunits that make up the hemoglobin protein: beta-globins and alpha-globins. Beta-hemoglobin is created from the genetic information on the HBB, or "hemoglobin, beta" gene found on chromosome 11p15.5. A single point mutation in this polypeptide chain, which is 147
The Body, the Blood, the Machine Hutch Harris and Kathy Foster. The Body, the Blood, the Machine The Body, the Blood, the Machine is the third studio album by American indie rock band The Thermals. The album was released on August 22, 2006 on Sub Pop Records, and was produced by Fugazi's Brendan Canty. According to the band's official website, "the album tells the story of a young couple who must flee a United States governed by fascist faux-Christians." The music review online magazine "Pitchfork" placed "The Body, the Blood, the Machine" at number 186 on their list of top 200 albums of the 2000s. All