Tendon induce endothelial cell proliferation and migration, and VEGF mRNA has been shown to be expressed at the site of tendon injuries along with collagen I mRNA. Bone morphogenetic proteins (BMPs) are a subgroup of TGF-β superfamily that can induce bone and cartilage formation as well as tissue differentiation, and BMP-12 specifically has been shown to influence formation and differentiation of tendon tissue and to promote fibrogenesis. In animal models, extensive studies have been conducted to investigate the effects of mechanical strain in the form of activity level on tendon injury and healing. While stretching can disrupt healing during the initial
Patellar tendon rupture Patellar tendon rupture Patellar tendon rupture is a tear of the tendon that connects the knee cap (patella) to the tibia. Often there is sudden onset of pain and walking is difficult. In a complete rupture the ability to extend that knee is decreased. A pop may be felt when it occurs. Injury to the patellar tendon generally requires a significant force such as falling directly on the knee or jumping from a height. Risk factors include patellar tendinitis, kidney failure, diabetes, and steroid or fluoroquinolone use. There are two main types of ruptures partial and complete. In most cases,