Hypothalamic–pituitary–thyroid axis control over the hypothalamus as well as anterior pituitary, thus controlling the release of both TRH from hypothalamus and TSH from anterior pituitary gland. The HPA, HPG, and HPT axes are three pathways in which the hypothalamus and pituitary direct neuroendocrine function. Thyroid homeostasis results from a multi-loop feedback system that is found in virtually all higher vertebrates. Proper function of thyrotropic feedback control is indispensable for growth, differentiation, reproduction and intelligence. Very few animals (e.g. axolotls and sloths) have impaired thyroid homeostasis that exhibits a very low set-point that is assumed to underlie the metabolic and ontogenetic anomalies of
Pituitary gland referred to the pituitary gland by only using the (Ancient Greek) name ἀδήν, "gland". He described the pituitary gland as part of a series of secretory organs for the excretion of nasal mucus. Anatomist Andreas Vesalius translated ἀδήν with "glans, in quam pituita destillat", "gland in which slime ("pituita") drips". Besides this 'descriptive' name, Vesalius used "glandula pituitaria", from which the English name "pituitary gland" is ultimately derived. The expression "glandula pituitaria" is still used as official synonym beside "hypophysis" in the official Latin nomenclature "Terminologia Anatomica". In the seventeenth century the supposed function of the pituitary gland to produce