Allergic inflammation immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema. The late phase of a Type 1 reaction (which develops 8–12
Mental substance Mental substance Mental substance is the idea held by dualists and idealists, that minds are made-up of non-physical substance. This substance is often referred to as consciousness. This is opposed to the materialists, who hold that what we normally think of as mental substance is ultimately physical matter (i.e., brains). Descartes, who was most famous for the assertion "I think therefore I am", has had a lot of influence on the mind–body problem. He describes his theory of mental substance (which he calls res cogitans distinguishing it from the "res extensa") in the "Second Meditation" (II.8) and in "Principia Philosophiae"