Pharmacokinetics of progesterone concentrations was around 4 hours and the elimination half-life was in the range of 30 to 40 hours. The venous blood levels observed were very low. Because progesterone is a lipophilic and hydrophobic compound, it is not absorbed efficiently by the skin. Moreover, because the body produces about 25 mg progesterone per day on average during the luteal phase, around 50% of the body would need to be used as a surface of absorption to deliver a similar quantity of progesterone. As such, the transdermal route cannot easily achieve adequate circulating progesterone levels, and this makes transdermal progesterone impractical for
Progesterone the female is. Prediction of birth date of the pending litter can be very accurate if ovulation date is known. Puppies deliver with a day or two of 9 weeks gestation in most cases. It is not possible to determine pregnancy using progesterone tests once a breeding has taken place however. This is due to the fact that, in dogs, progestrone levels remain elevated throughout the estrus period. Progesterone Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones