Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
What Alice Found Angeles Times": "Sweet, suspenseful, funny, poignant and adult. Judith Ivey gives flat-out one of the year's best performances... a terrific showcase for lovely newcomer Emily Grace...an unexpected treat for sophisticated audiences". "Variety" had Ms. Ivey as a dark horse Oscar candidate. "What Alice Found" was awarded the Grand Prize at the 2003 Deauville Festival of American Cinema by Jury Chair Roman Polanski. The film is held in the collection of the UCLA film archive and the screenplay was invited into the collection at the library of the Academy of Motion Picture Arts and Sciences. What Alice Found What Alice Found