Valeriana wallichii Valeriana wallichii Valeriana wallichii is a rhizome herb of the genus Valeriana and the family Valerianaceae also called Indian Valerian or Tagar-Ganthoda, not to be confused with ganthoda, the root of Indian long pepper. It is an herb useful in Ayurvedic medicine used as an analeptic, antispasmodic, carminative, sedative, stimulant, stomachic, and nervine. It grows in the Northwest Himalayas in places like Astore (Northern Pakistan) and forests in the region. The genus Valeriana, with about 200 species, belongs to the family Valerianaceae and has a distribution throughout the world. The Indian Valerian has long been used in Ayurveda (Charak Samhita
Kindling (sedative–hypnotic withdrawal) Kindling (sedative–hypnotic withdrawal) Kindling due to substance withdrawal refers to the neurological condition which results from repeated withdrawal episodes from sedative–hypnotic drugs such as alcohol and benzodiazepines. Each withdrawal leads to more severe withdrawal symptoms than in previous episodes. Individuals who have had more withdrawal episodes are at an increased risk of very severe withdrawal symptoms, up to and including seizures and death. Long-term use of GABAergic-acting sedative–hypnotic drugs causes chronic GABA receptor downregulation as well as glutamate overactivity, which can lead to drug and neurotransmitter sensitization, central nervous system hyperexcitability, and excitotoxicity. Binge drinking is believed to increase impulsivity