Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
The Water & the Blood music critics to critique the album. Matt Conner of "CCM Magazine" called this "impressive" and it was "especially powerful for its portrayal of the work of Christ." At "Alternative Press", Tim Karan noted that "This album was made for people who share Kensrue's views, not for those looking to denigrate them." Because of that, Karan wrote that "With all of that aside, "The Water & The Blood" is the closest thing to new Thrice any of us will be graced with for the foreseeable future, and if this is what church sounds like these days, Kensrue could beckon a whole