Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Nanotechnology for water purification pressure inside the can so that the water enters through the filtration membrane and gets filtered. Dirty water is carried inside the can itself while the filtered water is obtained from the filtered spout. Activated carbon filter removes chlorine, bad odour and taste. It also removes heavy metals, medical residues and chemical pesticides that include pesticides endocrine disrupting compounds. It also removes suspended particle in the water. The main purpose of lifesaver jerrycan is to remove the biological impurities. It includes the removal of bacteria, viruses, parasites and various forms of cysts. It can remove viruses greater than 99.999% (log