Nav1.5 kb. The gene consists of 28 exons, of which exon 1 and in part exon 2 form the 5’ untranslated region (5’UTR) and exon 28 the 3’ untranslated region (3’UTR) of the RNA. SCN5A is part of a family of 10 genes that encode different types of sodium channels, i.e. brain-type (Na1.1, Na1.2, Na1.3, Na1.6), neuronal channels (Na1.7, Na1.8 and Na1.9), skeletal muscle channels (Na1.4) and the cardiac sodium channel Na1.5. SCN5A is mainly expressed in the heart, where expression is abundant in working myocardium and conduction tissue. In contrast, expression is low in the sinoatrial node and atrioventricular node.
Bachmann's bundle found that clamping the muscular bundle of fibers that connects the atria caused a significant conduction delay. The Bachman's bundle receives its blood supply from the sinoatrial nodal artery (right, left or both). Besides Bachmann's bundle, the other three conduction tracts that constitute the "atrial conduction system" are known as the anterior, middle, and posterior tracts, which run from the sinoatrial node to the atrioventricular node, converging in the region near the coronary sinus. "Atrial automaticity foci" are within the atrial conduction system. The concentration of converging conduction tracts near the coronary sinus results in considerable automaticity activity originating in