Antibiotic-Antimycotic Antibiotic-Antimycotic Antibiotic-Antimycotic is a solution that is commonly added to cell culture media to prevent contamination by various bacteria and fungi. It generally contains 10,000 units per milliliter penicillin, 10,000 micrograms per milliliter streptomycin, and 25 micrograms per milliliter amphotericin B. Penicillin is a Beta-lactam antibiotic that is effective in inhibiting Gram-positive bacteria. Streptomycin is an aminoglycoside antibiotic which is effective against most Gram-negative bacteria. Amphotericin B is effective against multi-cellular fungi and yeasts. In human cell culture Antibiotic-Antimycotic solution was used to wash follicular aspirate and granulosa lutein cells to avoid microbial contamination during human oocyte retrieval for assisted
Antibiotic synergy potential therapies is moving in three primary directions. Some research is devoted to finding combinations of extant antibiotics which when combined exhibit synergy. A classic example of this effect is the interaction between β-lactams, which damage the bacteria cell membrane, and aminoglycosides, which inhibit protein synthesis. The damage dealt to the cell wall by β-lactams allows more aminoglycoside molecules to be taken up into the cell than would otherwise be possible, enhancing cell damage. In some cases, antibacterial combinations restore potency to ineffective drugs. Other research has been devoted to finding antibiotic resistance breakers (ARB's) which enhance an antibiotic's potency.