Anovulatory cycle want to get pregnant anovulation can be managed with the use of cyclic progesterone or progestin supplementation or use of hormonal contraception. Anovulatory cycle The anovulatory cycle is a menstrual cycle characterized by varying degrees of menstrual intervals and the absence of ovulation and a luteal phase. In the absence of ovulation, there will be infertility. While the normal menstrual cycle in the human typically lasts 4 weeks (28 days, range 24–35 days) and consists of a follicular phase, ovulation, and a luteal phase, followed by either menstruation or pregnancy, the anovulatory cycle has cycle lengths of varying degrees. In
Pharmacokinetics of progesterone biological half-life of progesterone in the circulation is very short; with intravenous injection, its half-life has ranged widely from 3 to 90 minutes in various studies. The metabolic clearance rate of progesterone ranges between 2,100 and 2,800 L/day, and is constant across the menstrual cycle. Progesterone is eliminated in bile and urine. Pharmacokinetics of progesterone The pharmacology of progesterone, a progestogen medication and naturally occurring steroid hormone, concerns its pharmacodynamics, pharmacokinetics, and various routes of administration. Progesterone is a naturally occurring and bioidentical progestogen, or an agonist of the progesterone receptor, the biological target of progestogens like endogenous progesterone. Progesterone