Progesterone and is responsible for approximately 70% of cytochrome P450-mediated progesterone metabolism. Other routes include 6α-, 16α-, and 16β-hydroxylation. However, treatment of women with ketoconazole, a strong CYP3A4 inhibitor, had minimal effects on progesterone levels, producing only a slight and non-significant increase, and this suggests that cytochrome P450 enzymes play only a small role in progesterone metabolism. In women, progesterone levels are relatively low during the preovulatory phase of the menstrual cycle, rise after ovulation, and are elevated during the luteal phase, as shown in diagram below. Progesterone levels tend to be less than 2 ng/mL prior to ovulation, and greater
Menstrual synchrony synchrony. Setchella, Kendala, and Tyniec investigated whether menstrual synchrony occurred in a semi-free-ranging population of mandrills of 10-group years. They reported that mandrills do not synchronize their menstrual cycles and concluded that cycle synchrony does not occur in non-human primates. Oestrus synchrony has been reported of female lions living under natural conditions in the wild. Menstrual synchrony Menstrual synchrony, also called the McClintock effect, is an alleged process whereby women who begin living together in close proximity experience their menstrual cycle onsets (the onset of menstruation or menses) becoming more synchronized together in time than when previously living apart. "For