Recreational drug use are caused by an excessive response of the body to allergens, such as the pollen released by grasses and trees. An allergic reaction causes release of histamine by the body. Other uses of antihistamines are to help with normal symptoms of insect stings even if there is no allergic reaction. Their recreational appeal exists mainly due to their anticholinergic properties, that induce anxiolysis and, in some cases such as diphenhydramine, chlorpheniramine, and orphenadrine, a characteristic euphoria at moderate doses. High dosages taken to induce recreational drug effects may lead to overdoses. Antihistamines are also consumed in combination with alcohol, particularly
Mental substance Mental substance Mental substance is the idea held by dualists and idealists, that minds are made-up of non-physical substance. This substance is often referred to as consciousness. This is opposed to the materialists, who hold that what we normally think of as mental substance is ultimately physical matter (i.e., brains). Descartes, who was most famous for the assertion "I think therefore I am", has had a lot of influence on the mind–body problem. He describes his theory of mental substance (which he calls res cogitans distinguishing it from the "res extensa") in the "Second Meditation" (II.8) and in "Principia Philosophiae"