Scar healing which heals with a scar. The myofibroblasts make up a high proportion of the fibroblasts proliferating in the postembryonic wound at the onset of healing. In the rat model, for instance, myofibroblasts can constitute up to 70% of the fibroblasts, and is responsible for fibrosis on tissue. Generally, the myofibroblasts disappear from the wound within 30 days, but can stay around in pathological cases in hypertrophy, such as keloids. Myofibroblasts have plasticity and in mice can be transformed into fat cells, instead of scar tissue, via the regeneration of hair follicles. Early and effective treatment of acne scarring can
Scar Tissue New Zealand and Canada, where it reached numbers three and four, respectively. "Scar Tissue" is considered to be representative of the new, more melodic rock sound the band experimented with on "Californication" (in contrast to the psychedelic "One Hot Minute", and dry funk of "Blood Sugar Sex Magik"). The song is notable for its mellow intro guitar riff and for its slide guitar solos throughout. "Guitar World" placed the guitar solo 63rd in its list of the "100 Greatest Guitar Solos". "Scar Tissue" won a Grammy Award for Best Rock Song in 2000. In 2004, Anthony Kiedis published "Scar Tissue".