Endocrine gland been implicated in proliferation, one of the required steps of oncogenesis. Other common diseases that result from endocrine dysfunction include Addison’s disease, Cushing’s disease and Grave’s disease. Cushing's disease and Addison's disease are pathologies involving the dysfunction of the adrenal gland. Dysfunction in the adrenal gland could be due to primary or secondary factors and can result in hypercortisolism or hypocortisolism . Cushing’s disease is characterized by the hypersecretion of the adrenocorticotropic hormone (ACTH) due to a pituitary adenoma that ultimately causes endogenous hypercortisolism by stimulating the adrenal glands. Some clinical signs of Cushing’s disease include obesity, moon face, and
Gastric glands neck cells" that produce mucus. This is thought to be different from the mucus produced by the gastric mucosa. Fundic glands found in the fundus and also in the body have another two cell types–gastric chief cells and parietal cells (oxyntic)). The chief cells are found in the basal regions of the gland and release a zymogen – pepsinogen, a precursor to pepsin. The parietal cells ("parietal" means "relating to a wall") are found in the walls of the tubes. The parietal cells secrete hydrochloric acid–the main component of gastric acid. This needs to be readily available for the stomach