Valerian (herb) some affinity for the GABA receptor, a class of receptors on which benzodiazepines are known to act. Valeric acid, which is responsible for the typical odor of mostly older valerian roots, does not have any sedative properties. Valeric acid is related to valproic acid, a widely prescribed anticonvulsant; valproic acid is a derivative of valeric acid. Valerian also contains isovaltrate, which has been shown to be an inverse agonist for adenosine A receptor sites. This action likely does not contribute to the herb's possible sedative effects, which would be expected from an agonist, rather than an inverse agonist, at this
Valerian and the City of a Thousand Planets first film to displace "Wolf Warriors 2" at the country's box office. It went on to open to $29 million, topping the box office. The largest territory for the film was China, with . "Valerian" received mixed reviews from critics, who praised its visuals while criticizing the plot and some of the casting. On review aggregation website Rotten Tomatoes, the film has an approval rating of 48% based on 256 reviews, with an average rating of 5.5/10. The site's critical consensus reads, ""Valerian and the City of a Thousand Planets" uses sheer kinetic energy and visual thrills to overcome narrative