Human brain in the midline on top of the brain. Blood from here joins with blood from the straight sinus at the confluence of sinuses. Blood from here drains into the left and right transverse sinuses. These then drain into the sigmoid sinuses, which receive blood from the cavernous sinus and superior and inferior petrosal sinuses. The sigmoid drains into the large internal jugular veins. The larger arteries throughout the brain supply blood to smaller capillaries. These smallest of blood vessels in the brain, are lined with cells joined by tight junctions and so fluids do not seep in or leak out
Drug delivery to the brain Drug delivery to the brain Drug delivery to the brain is the process of passing therapeutically active molecules across the blood–brain barrier for the purpose of treating brain maladies. This is a complex process that must take into account the complex anatomy of the brain as well as the restrictions imposed by the special junctions of the blood–brain barrier. The blood–brain barrier is formed by special tight junctions between the epithelial cells that surround the brain tissue. All tissue is separated by this layer of epithelial cells, however only the brain epithelial cells have these tight junctions that do not