Red blood cell wide variety of endogenous mediators and xenobiotics. Excessive eryptosis is observed in red blood cells lacking the cGMP-dependent protein kinase type I or the AMP-activated protein kinase AMPK. Inhibitors of eryptosis include erythropoietin, nitric oxide, catecholamines and high concentrations of urea. Much of the resulting breakdown products are recirculated in the body. The heme constituent of hemoglobin are broken down into iron (Fe) and biliverdin. The biliverdin is reduced to bilirubin, which is released into the plasma and recirculated to the liver bound to albumin. The iron is released into the plasma to be recirculated by a carrier protein called
Blood agent immediate cause of death is usually respiratory failure. Blood agents work at the cellular level by preventing the exchange of oxygen and carbon dioxide between the blood and the body's cells. This causes the cells to suffocate from lack of oxygen. Cyanide-based agents do so by interrupting the electron transport chain in the inner membranes of mitochondria. Arsine damages the red blood cells which deliver oxygen throughout the body. Chemical detection methods, in the form of kits or testing strips, exist for hydrogen cyanide. Ordinary clothing provides some protection, but proper protective clothing and masks are recommended. Mask filters containing