Glycogen phosphorylase In the liver, glucagon activates another G-protein-linked receptor that triggers a different cascade, resulting in the activation of Phospholipase C (PLC). PLC indirectly causes the release of calcium from the hepatocytes' endoplasmic reticulum into the cytosol. The increased calcium availability binds to the calmodulin subunit and activates glycogen phosphorylase kinase. Glycogen phosphorylase kinase activates glycogen phosphorylase in the same manner mentioned previously. Glycogen phosphorylase b is not always inactive in muscle, as it can be activated allosterically by AMP. An increase in AMP concentration, which occurs during strenuous exercise, signals energy demand. AMP activates glycogen phosphorylase b by changing its
Metropolitan Stores wholly owned Canadian subsidiary of Metropolitan Stores Ltd. to investment bankers James Richardson & Sons Ltd. of Winnipeg, Manitoba for approximately $19 million in cash, which returned the company to 100 per cent Canadian ownership. The agreement brought 86 stores and one warehouse located mainly in Ontario, Quebec and Winnipeg with annual sales in excess of $20 million and an annual profit after taxes of more than $1 million. Following the purchase, James Richardson & Sons transferred the business of Metropolitan Stores Ltd. to a newly formed Canadian corporation that became known as Metropolitan Stores of Canada Ltd. Two months