Allergic inflammation immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema. The late phase of a Type 1 reaction (which develops 8–12
Double Allergic officially, but "Living Type" was voted into the Triple J Hottest 100 in 1996. Critics were generally favorable in their reviews of "Double Allergic". It was praised by Allmusic reviewer Jonathan Lewis as "a cohesive and mature effort". It has also been certified platinum three times, with over 200,000 copies sold. "Double Allergic" was also nominated for five ARIA awards, with singles from the album nominated for an additional four, however, it won none of the awards it was nominated for. "Double Allergic" contained material that had been written by Powderfinger in 1995 and 1996. Prior to its release, guitarist