Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
The Water & the Blood told that Kensrue made "a passionate worship album that doesn't stifle the creativity of the artist. This album is Kensrue's "The Water & The Blood"." At The Christian Music Review Blog, Jonathan Kemp stated that ""The Water & The Blood" is a fantastic release from an artist who never ceases to innovate." For the "Billboard" charting week of October 19, 2013, "The Water & the Blood" was the No. 52 most sold album in the entirety of the United States via the "Billboard" 200, and it was the No. 4 most sold Top Christian Albums and the No. 8 most