Light skin of UVA can penetrate deeply into the dermis in persons with light skin pigmentation with little protective melanin pigment. The characteristic of fair skin, red hair, and freckling is associated with high amount of pheomelanin, little amounts of eumelanin. This phenotype is caused by a loss-of-function mutation in the melanocortin 1 receptor (MC1R) gene. However, variations in the MC1R gene sequence only have considerable influence on pigmentation in populations where red hair and extremely fair skin is prevalent. The gene variation’s primary effect is to promote eumelanin synthesis at the expense of pheomelanin synthesis, although this contributes to very little
Lake pigment rich red color. They were very often used by Titian and other Venetian artists of the 16th century to depict fine draperies and fabrics. Indigo and rose madder are now produced more cheaply from synthetic sources, although some use of natural products persists, especially among artisans. The food and cosmetics industries have shown renewed interest in cochineal as a source of natural red dye. Lake pigment A lake pigment is a pigment made by precipitating a dye with an inert binder, or "mordant", usually a metallic salt. Unlike vermilion, ultramarine, and other pigments made from ground minerals, lake pigments are