Tendon induce endothelial cell proliferation and migration, and VEGF mRNA has been shown to be expressed at the site of tendon injuries along with collagen I mRNA. Bone morphogenetic proteins (BMPs) are a subgroup of TGF-β superfamily that can induce bone and cartilage formation as well as tissue differentiation, and BMP-12 specifically has been shown to influence formation and differentiation of tendon tissue and to promote fibrogenesis. In animal models, extensive studies have been conducted to investigate the effects of mechanical strain in the form of activity level on tendon injury and healing. While stretching can disrupt healing during the initial
Patellar tendon rupture weakness after the injury and repair. If the tendon rupture is a partial tear (without the two parts of the tendon being separated) then non-surgical methods of treatment may suffice. The future of non-surgical care for partial patella tendon ruptures is likely bioengineering. Ligament reconstruction is possible using mesenchymal stem cells and a silk scaffold. These same stem cells have been shown to be capable of seeding repair of damaged animal tendons. In 2010, a clinical study proved that mechanical loading of the tendon callus during the remodelling phase leads to healing by regeneration. Patellar tendon rupture Patellar tendon rupture