Endocrine disruptor occur from low-dose exposure to exogenous hormones or hormonally active chemicals such as bisphenol A. These chemical can bind to receptors for other hormonally mediated processes. Furthermore, since endogenous hormones are already present in the body in biologically active concentrations, additional exposure to relatively small amounts of exogenous hormonally active substances can disrupt the proper functioning of the body's endocrine system. Thus, an endocrine disruptor can elicit adverse effects at much lower doses than a toxicity, acting through a different mechanism. The timing of exposure is also critical. Most critical stages of development occur in utero, where the fertilized egg
Labial glands Labial glands The labial glands are minor salivary glands situated between the mucous membrane and the orbicularis oris around the orifice of the mouth. They are circular in form, and about the size of small peas; their ducts open by minute orifices upon the mucous membrane. Like the parotid and buccal glands, the labial glands are innervated by parasympathetic fibres that arise in the inferior salivatory nucleus, travel with the glossopharyngeal nerve and lesser petrosal nerve to the otic ganglion, where they synapse and then continue to the labial glands. Sympathetic innervation is mediated by postganglionary fibres which arise in