Valerian (herb) some affinity for the GABA receptor, a class of receptors on which benzodiazepines are known to act. Valeric acid, which is responsible for the typical odor of mostly older valerian roots, does not have any sedative properties. Valeric acid is related to valproic acid, a widely prescribed anticonvulsant; valproic acid is a derivative of valeric acid. Valerian also contains isovaltrate, which has been shown to be an inverse agonist for adenosine A receptor sites. This action likely does not contribute to the herb's possible sedative effects, which would be expected from an agonist, rather than an inverse agonist, at this
Valerian (emperor) had fallen into the hands of a Sassanid vassal and Armenia was occupied by Shapur I (Sapor). Valerian and Gallienus split the problems of the empire between them, with the son taking the West, and the father heading East to face the Persian threat. In 254, 255, and 257, Valerian again became "Consul Ordinarius." By 257, he had recovered Antioch and returned the province of Syria to Roman control. The following year, the Goths ravaged Asia Minor. In 259, Valerian moved on to Edessa, but an outbreak of plague killed a critical number of legionaries, weakening the Roman position, and