Tooth whitening enamel layer may also be gradually thinned or even perforated by the various forms of tooth wear. Teeth may be darkened by a buildup of surface stains (extrinsic staining), which hides the natural tooth color; or the tooth itself may discolor (intrinsic staining). Extrinsic stains can become internalised through enamel defects or cracks or as a result of dentine becoming exposed but most extrinsic stains appear to be deposited on or in the dental pellicle. Causes of extrinsic staining include: Changes in the thickness of the dental hard tissues would result in intrinsic discolouration. There are a few causal factors
Human tooth development through cementum. NGF-R is present in the condensing ectomesenchymal cells of the dental papilla in the early cap stage tooth germ and plays multiple roles during morphogenetic and cytodifferentiation events in the tooth. There is a relationship between tooth agenesis and absence of the peripheral trigeminal nerve (see Hypodontia). All stages (bud, cap, bell, crown), growth and morphogenesis of the teeth are regulated by a protein called sonic hedgehog. Various phenotypic inputs modulate the size of the teeth. Parathyroid hormone is required for tooth eruption. The following tables present the development timeline of human teeth. Times for the initial calcification