Apparent mineralocorticoid excess syndrome cases recorded worldwide. Liquorice consumption may also cause a temporary form of AME due to its ability to block 11β-hydroxysteroid dehydrogenase type 2, in turn causing increased levels of cortisol. Cessation of licorice consumption will reverse this form of AME. Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In
Pipe organ can be viewed at List of pipe organs. The origins of the pipe organ can be traced back to the water organ in Ancient Greece, in the 3rd century BC, in which the wind supply was created with water pressure. By the 6th or 7th century AD, bellows were used to supply organs with wind. Beginning in the 12th century, the organ began to evolve into a complex instrument capable of producing different timbres. A pipe organ with "great leaden pipes" was sent to the West by the Byzantine emperor Constantine V as a gift to Pepin the Short, King