Estradiol for tissue of the reproductive organs, supporting the lining of the vagina, the cervical glands, the endometrium, and the lining of the fallopian tubes. It enhances growth of the myometrium. Estradiol appears necessary to maintain oocytes in the ovary. During the menstrual cycle, estradiol produced by the growing follicles triggers, via a positive feedback system, the hypothalamic-pituitary events that lead to the luteinizing hormone surge, inducing ovulation. In the luteal phase, estradiol, in conjunction with progesterone, prepares the endometrium for implantation. During pregnancy, estradiol increases due to placental production. The effect of estradiol, together with estrone and estriol, in pregnancy
Centre for Menstrual Cycle and Ovulation Research Centre for Menstrual Cycle and Ovulation Research The Centre for Menstrual Cycle and Ovulation Research (CeMCOR) is a health research centre in Vancouver. According to the University of British Columbia, CeMCOR is the only centre in the world that focuses on ovulation and the causes and consequences of ovulation disturbances. CeMCOR is known for research on progesterone-only therapy for menopausal hot flushes, research on perimenopause as distinct from menopause, and for a focus on women's perspectives and self-knowledge. The Centre was founded by Dr. Jerilynn Prior in May 2002 as a charity affiliated with the University of British Columbia. The