Dark skin gives seven to eightfold protection against DNA damage, but even the darkest skin colour cannot protect against all damage to DNA. Dark skin offers great protection against UVR because of its eumelanin content, the UVR-absorbing capabilities of large melanosomes, and because eumelanin can be mobilized faster and brought to the surface of the skin from the depths of the epidermis. For the same body region, light- and dark-skinned individuals have similar numbers of melanocytes (there is considerable variation between different body regions), but pigment-containing organelles, called melanosomes, are larger and more numerous in dark-skinned individuals. Keratocytes from dark skin cocultured
Pigment carmine was popular in Europe, blue remained an exclusive color, associated with wealth and status. The 17th-century Dutch master Johannes Vermeer often made lavish use of lapis lazuli, along with carmine and Indian yellow, in his vibrant paintings. The earliest known pigments were natural minerals. Natural iron oxides give a range of colors and are found in many Paleolithic and Neolithic cave paintings. Two examples include Red Ochre, anhydrous FeO, and the hydrated Yellow Ochre (FeOHO). Charcoal—or carbon black—has also been used as a black pigment since prehistoric times. Two of the first synthetic pigments were white lead (basic lead