Pleiotropy to have protein. Sickle cell anemia is a genetic disease that causes deformed red blood cells with a rigid, crescent shape instead of the normal flexible, round shape. It is caused by a change in one nucleotide, a point mutation in the HBB gene. The HBB gene encodes information to make the beta-globin subunit of hemoglobin, which is the protein red blood cells use to carry oxygen throughout the body. Sickle cell anemia occurs when the HBB gene mutation causes both beta-globin subunits of hemoglobin to change into hemoglobinS (HbS). Sickle cell anemia is a pleiotropic disease because the expression
The Body, the Blood, the Machine The Body, the Blood, the Machine The Body, the Blood, the Machine is the third studio album by American indie rock band The Thermals. The album was released on August 22, 2006 on Sub Pop Records, and was produced by Fugazi's Brendan Canty. According to the band's official website, "the album tells the story of a young couple who must flee a United States governed by fascist faux-Christians." The music review online magazine "Pitchfork" placed "The Body, the Blood, the Machine" at number 186 on their list of top 200 albums of the 2000s. All songs written and arranged by