Leg hair follicle it pushed older cells out and that is what becomes the leg hair. After the older cells become hard and leave the follicle, they form a hair shaft. The hair shaft is mostly made up of dead tissue and a protein that is known as keratin. It is said that hair growth occurs during the "growing" phase of the follicle, and then retained as dead club hair during the "resting" phase. The old club hair might be lost within the following "growing" phase. Men are seen to be much hairier than women, even though men and women are much
Retinoblastoma protein of DREAM requires DYRK1A (Ser/Thr kinase) dependant phosphorylation of the MuvB core component, Lin52 at Serine28. This mechanism is crucial for recruitment of p130/p107 to the MuvB core and thus DREAM assembly. The retinoblastoma protein is involved in the growth and development of mammalian hair cells of the cochlea, and appears to be related to the cells' inability to regenerate. Embryonic hair cells require Rb, among other important proteins, to exit the cell-cycle and stop dividing, which allows maturation of the auditory system. Once wild-type mammals have reached adulthood, their cochlear hair cells become incapable of proliferation. In studies where