Bachmann's bundle that area. The normal cardiac rhythm originates in the sinoatrial node, which is located in the right atrium near the superior vena cava. From there, the electrical activation spreads throughout the right atrium. There are at least four different locations where the activation can pass to the left atrium. Apart from Bachmann's bundle these are the anterior interatrial septum, posterior interatrial septum, and the coronary sinus. Because it originates close to the sinoatrial node and consists of long parallel fibers, Bachmann's bundle is, during sinus rhythm, the first of these connections to activate the left atrium. Bachmann's bundle In the
Lymph node and fixed macrophages. The subcapsular sinus has clinical importance as it is the most likely location where the earliest manifestations of a metastatic carcinoma in a lymph node would be found. The cortex of the lymph node is the outer portion of the node, underneath the capsule and the subcapsular sinus. It has an outer superficial part and a deeper part known as the paracortex. The subcapsular sinus drains to the trabecular sinuses, and then the lymph flows into the medullary sinuses. The outer cortex consists mainly of the B cells arranged as follicles, which may develop a germinal center