Endocrine disruptor occur from low-dose exposure to exogenous hormones or hormonally active chemicals such as bisphenol A. These chemical can bind to receptors for other hormonally mediated processes. Furthermore, since endogenous hormones are already present in the body in biologically active concentrations, additional exposure to relatively small amounts of exogenous hormonally active substances can disrupt the proper functioning of the body's endocrine system. Thus, an endocrine disruptor can elicit adverse effects at much lower doses than a toxicity, acting through a different mechanism. The timing of exposure is also critical. Most critical stages of development occur in utero, where the fertilized egg
Endocrine disruptor to a lot of controversy due its potential estrogenic effect in humans. Tributyltin (TBT) are organotin compounds that for 40 years TBT was used as a biocide in anti-fouling paint, commonly known as bottom paint. TBT has been shown to impact invertebrate and vertebrate development, disrupting the endocrine system, resulting in masculinization, lower survival rates, as well as many health problems in mammals. Since being banned, the average human body burdens of DDT and PCB have been declining. Since their ban in 1972, the PCB body burden in 2009 is one-hundredth of what it was in the early 1980s. On