Gonadal dysgenesis If a single or combination of these genes are mutated or deleted, downstream signalling is disrupted, leading to malformation of male external genitalia. SRY acts on gene SOX9 which drives Sertoli cell formation and testis differentiation. An absence in SRY causes SOX9 to not be expressed at the appropriate time or concentration, leading to a deficiency in testosterone and Anti-Müllerian hormone production. Inadequate levels of testosterone and Anti-Müllerian hormone disrupts the development of Wolffian ducts and internal genitalia that are key to male reproductive tract development. The lack of the male associated steroid hormones drives Müllerian duct development and perusal
Sexual desire and intimate relationships primary goal of sexual desire. It has also been suggested that women are more likely than men to develop a “relational” or “person-centered” orientation to sexual desire, whereas men are more likely to adopt a “recreational” or “body-centered” orientation to sexuality. These results further support the suggestion that despite generally consistent definitions of sexual desire, perceived differing end goals of sexual desire may exist between the sexes. In keeping with providing definitions of sexual desire consistent with those of theorists, both men and women have consistently expressed their beliefs that the causes of male sexual desire differ from female causes