Emissary veins passing through the foramen ovale, jugular foramen, foramen lacerum, and hypoglossal canal. Because the emissary veins are valveless, they are an important part in selective brain cooling through bidirectional flow of cooler blood from the evaporating surface of the head. In general, blood flow is from external to internal but the flow can be altered by increased intracranial pressure. A type of emissary vein goes through the sphenoidal emissary foramen inferior to the zygomatic arch with the cavernous sinus on the inside of the skull. This is an important route for spread of infection because cranial nerve VI and the
Drug delivery to the brain it "may reflect an influence of the astrocytes on the formation and the maintenance of the blood–brain barrier. The main function of the blood–brain barrier is to protect the brain and keep it isolated from harmful toxins that are potentially in the blood stream. It accomplishes this because of its structure, as is usual in the body that structure defines its function. The tight junctions between the endothelial cells prevent large molecules as well as many ions from passing between the junction spaces. This forces molecules to go through the endothelial cells in order to enter the brain tissue, meaning