Antibiotic synergy with enterococcal endocarditis experienced a high relapse rate when penicillin G alone was used for treatment and a demonstrably lower relapse rate when streptomycin was combined with penicillin G to combat the infection. Since that time the research community has conducted numerous studies regarding the effects and possibilities of antibiotic combinations. Today, combination therapy is recognized as providing a broad spectrum of antibiotic coverage, effectively fighting polymicrobial infections, minimizing selection for antibiotic resistant strains, lowering dose toxicity where applicable, and in some cases providing synergistic activity. Antibiotic synergy is desirable in a clinic sense for several reasons. At the patient
Antibiotic use in livestock of antibiotic usage in livestock transferring to humans has been well documented for over 40 years. It was first documented in 1976, where a study followed a novel antibiotic being used in livestock. The bacteria in animals and workers were regularly followed to record translational effects. The findings revealed that within 2 weeks, the bacteria found in the guts of animals fed antibiotics were resistant to the new antibiotic. Additionally, the resistant bacteria had spread to farm's laborers within 6 months. The bacteria in the stool of the laborers were tested and contained more than 80% resistance to the initial