Sexual attraction existed in different cultures is controversial. Pheromones have been determined to play a role in sexual attraction between people. They influence gonadal hormone secretion, for example, follicle maturation in the ovaries in females and testosterone and sperm production in males. Research conducted by Donald G. Dutton and Arthur P. Aron in the 1970s aimed to find the relation between sexual attraction and high anxiety conditions. In doing so, 85 male participants were contacted by an attractive female interviewer at either a fear-arousing suspension bridge or a normal bridge. Conclusively, it was shown that the male participants who were asked to
Transgender hormone therapy (male-to-female) suggesting a protective role of the male sex-determination chromosome. On the other hand, men with Klinefelter's syndrome (two X chromosomes and one Y chromosome), which causes hypoandrogenism, hyperestrogenism, and a very high incidence of gynecomastia (80%), have a dramatically (20- to 58-fold) increased risk of breast cancer compared to men with one X chromosome, closer to the rate of homogametic females. The incidences of breast cancer in karyotypical men (46,XY karyotype), men with Klinefelter's syndrome (47,XXY karyotype), and karyotypical women (46,XX karyotype) are approximately 0.1%, 3%, and 12.5%, respectively. Individuals with the 46,XY karyotype affected by complete androgen insensitivity syndrome