History of aspirin Peto convinced the U.S. FDA and much of the medical community that the aspirin studies, in aggregate, showed aspirin's effectiveness with relative certainty. By the end of the 1980s, aspirin was widely used as a preventive drug for heart attacks and had regained its former position as the top-selling analgesic in the U.S. History of aspirin The history of aspirin (IUPAC name acetylsalicylic acid ) begins with its synthesis and manufacture in 1899. Before that, salicylic acid had been used medicinally since antiquity. Medicines made from willow and other salicylate-rich plants appear in clay tablets from ancient Sumer as well
Moronic acid resistant to (bevirimat). This derivative has become a new lead for clinical trials and is also active against herpes simplex virus 1. Moronic acid Moronic acid (3-oxoolean-18-en-28-oic acid) is a natural triterpene. Moronic acid can be extracted from "Rhus javanica", a sumac plant traditionally believed to hold medicinal applications. The molecule has also been extracted from Mistletoe ("Phoradendron reichenbachianum"). Bevirimat, a derivative of the related triterpenoid betulinic acid, is under development as an anti-HIV drug; however, moronic acid has shown better antiviral profiles "in vitro" than bevirimat. A particular moronic acid derivative showed potent anti-HIV activity with EC values of