Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Pipe organ pressures are on the order of . Organ builders often measure organ wind using a U-tube manometer containing water, so commonly give its magnitude as the difference in water levels in the two legs of the manometer, rather than in units of pressure. The difference in water level is proportional to the difference in pressure between the wind being measured and the atmosphere. The 0.10 psi above would register as 2.75 inches of water (70 mmAq). An Italian organ from the Renaissance period may be on only , while (in the extreme) solo stops in some large 20th-century organs may