Tetrachromacy class eventually lose two of their four cones. The normal explanation of tetrachromacy is that the organism's retina contains four types of higher-intensity light receptor (called cone cells in vertebrates as opposed to rod cells, which are lower intensity light receptors) with different absorption spectra. This means that the animal may see wavelengths beyond those of a typical human being's eyesight, and may be able to distinguish between colors that, to a normal human, appear to be identical. Species with tetrachromatic color vision may have an unknown physiological advantage over rival species. The goldfish ("Carassius auratus auratus") and zebrafish ("Danio
Gene therapy of the human retina and RPE layer, in a short surgical procedure. Although this is more invasive than the intravitreal route, the fluid is absorbed by the RPE and the retina flattens in less than 14 hours without complications. Intravitreal AAV targets retinal ganglion cells and a few Muller glial cells. Subretinal AAV efficiently targets photoreceptors and RPE cells. The reason that different routes of administration lead to different cell types being transfected (e.g., different tropism) is that the inner limiting membrane (ILM) and the various retinal layers act as physical barriers for the delivery of drugs and vectors to the deeper retinal layers.