Hair coloring by lay people may not be sufficiently accurate. Hair that has been damaged by excessive exposure to chemicals is considered "over-processed". This results in dry, rough and fragile hair. In extreme cases, the hair can be so damaged that it breaks off entirely. The main cases of hair breakage are: Lack of moisture and oils, poor diet, stress, over processing or illness. Skin and fingernails are made of a similar type of keratinized protein as hair. That means that drips, slips and extra hair tint around the hairline can result in patches of discolored skin. This is more common with
Cleft lip and palate transmembrane protein 1 may belong to a new gene family. This family also contains the "Homo sapiens" cisplatin resistance related protein CRR9p which is associated with CDDP-induced apoptosis. Cleft lip and palate transmembrane protein 1 Cleft lip and palate transmembrane protein 1 is a protein that in humans is encoded by the "CLPTM1" gene. It belongs to a family of several eukaryotic cleft lip and palate transmembrane protein 1 sequences. Cleft lip with or without cleft palate is a common birth defect that is genetically complex. The nonsyndromic forms have been studied genetically using linkage and candidate-gene association studies with only partial success