Light effects on circadian rhythm collected by rod cells and cone cells and the retinal ganglion cells (RGCs), or it is directly collected by these RGCs. The RGCs use the photopigment melanopsin to absorb the light energy. Specifically, this class of RGCs being discussed is referred to as "intrinsically photosensitive," which just means they are sensitive to light. There are five known types of intrinsically photosensitive retinal ganglion cells (ipRGCs): M1, M2, M3, M4, and M5. Each of these differently ipRGC types have different melanopsin content and photosensitivity. These connect to amacrine cells in the inner plexiform layer of the retina. Ultimately, via this retinohypothalamic
Macula of retina shown to prevent the disease. After death or enucleation (removal of the eye) the macula appears yellow, a color that is not visible in the living eye except when viewed with light from which red has been filtered. Structures in the macula are specialized for high-acuity vision. Within the macula are the fovea and foveola that both contain a high density of cones, which are nerve cells that are photoreceptors with high acuity. In details, the normal human eye contains three different types of cones, with different ranges of spectral sensitivity. The brain combines the signals from neighboring cones to