Skin whitening cells causes the skin to naturally regenerate itself. Excess melanin comes to the surface and peels off in a few days. This is particularly useful in sensitive areas like the genitals where laser treatment could leave a scar. Efficacy of the treatment depends on the depth of the pigment. There is evidence to suggest that some types of skin-whitening products use active ingredients, such as mercurous chloride and hydroquinone, which can be harmful. Hydroquinone is not available without a prescription in Europe. It is only available when prescribed by a medical doctor (e.g. a general practitioner). This is also the
Pigment carmine was popular in Europe, blue remained an exclusive color, associated with wealth and status. The 17th-century Dutch master Johannes Vermeer often made lavish use of lapis lazuli, along with carmine and Indian yellow, in his vibrant paintings. The earliest known pigments were natural minerals. Natural iron oxides give a range of colors and are found in many Paleolithic and Neolithic cave paintings. Two examples include Red Ochre, anhydrous FeO, and the hydrated Yellow Ochre (FeOHO). Charcoal—or carbon black—has also been used as a black pigment since prehistoric times. Two of the first synthetic pigments were white lead (basic lead