Valerian (herb) particular binding site. Hydrophilic extractions of the herb commonly sold over the counter, however, probably do not contain significant amounts of isovaltrate. Valerenic acid in valerian stimulates serotonin receptors as a partial agonist, including 5-HT which is implicated in the sleep-wake cycle. The chief constituent of valerian is a yellowish-green to brownish-yellow oil present in the dried root, varying in content from 0.5 to 2.0%. This variation in quantity may be determined by location; a dry, stony soil yields a root richer in oil than moist, fertile soil. The volatile oils that form the active ingredient are pungent, somewhat reminiscent
Valerian II Illyrian provinces while Gallienus transferred his attentions to Germany to deal with barbarian incursions into Gaul. Because of his youth (he was probably no more than fifteen at the time), Valerian was put under the guardianship of Ingenuus, who seems to have held an extraordinary command as governor of the Illyrian provinces, i.e. Upper and Lower Pannonia and Upper and Lower Moesia. It is reported that Salonina was not happy with this arrangement. Although she could not publicly dispute the decisions of Valerian, the "pater patriae" which had been formally agreed by her husband, Gallienus, she suspected Ingenuus's motives and