Glycogen branching enzyme leads to increased osmotic pressure resulting in cellular swelling and death. The tissues most affected by this disease are the liver, heart, and neuromuscular system, areas with the greatest levels of glycogen accumulation. Abnormal glycogen buildup in the liver interferes with liver functioning and can result in an enlarged liver and liver disease. In muscles, the inability of cells to efficiently breakdown glycogen due to the severe reduction or absence of branching can lead to muscle weakness and atrophy. At least three mutations in the GBE1 gene have been found to cause another disease called adult polyglucosan body disease (APBD).
The body in traditional Chinese medicine of all the Yin and Yang energy in the body. The Kidneys also govern the endocrine system, receive air from the lungs, govern bones, govern teeth, control water in the body, and store essence. Dysfunction of the Kidneys leads to deficiencies of Yin or Yang. It also leads to imbalanced hormones, weak bones, an impaired sex drive, and dizziness. Water in excess leads to bipolar disorder. Depressive episodes are characterized by Kidney Yin excess while manic episodes are characterized by Kidney Yang excess. The Kidney Meridian begins on the sole, moves up the inner leg to the groin, up the