Anatomy of the cerebellum a narrow midline zone called the "vermis". A set of large folds are conventionally used to divide the overall structure into ten smaller lobules. Because of its large number of tiny granule cells, the cerebellum contains more neurons than the rest of the brain put together, but it only takes up 10% of total brain volume. The cerebellum receives nearly 200 million input fibers; in contrast, the optic nerve is composed of a mere one million fibers. The unusual surface appearance of the cerebellum conceals the fact that the bulk of the structure is made up of a very tightly
Antigen transfer in the thymus in thymic medulla, namely clonal deletion ("recessive tolerance") and T Regulatory cells selection ("dominant tolerance") which force autoreactive T cells to apoptosis or skew them into suppressor T regulatory cells (TRegs), respectively, in order to protect body against manifestations of autoimmunity. These processes are mediated especially by unique subset of stromal cells called Medullary thymic epithelial cells (mTECs) via presentation of Tissue restricted antigens (TRAs) that represent self tissues from almost all parts of the body. mTECs are not only capable to present TRAs as efficient APCs. They are also potent in production of these TRAs via unique process called