Valerian (herb) mild nervous tension and to aid sleep; EMA stated that although there is insufficient evidence from clinical studies, its effectiveness as a dried extract is considered plausible. In the United States, valerian extracts are sold as a nutritional supplement under the Dietary Supplement Health and Education Act of 1994. Oral forms are available in both standardized and unstandardized forms. Standardized products may be preferable considering the wide variation of the chemicals in the dried root, as noted above. When standardized, it is done so as a percentage of valerenic acid or valeric acid. Because the compounds in valerian produce central
Sedative Sedative A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are central nervous depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but the majority of them affect the neurotransmitter gamma-aminobutyric acid (GABA), which are brain chemicals performing communication between brain cells. In spite of the fact that each sedative acts in its own way, they produce beneficial relaxing effect by increasing GABA activity. At higher doses it may result in slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes. Doses of sedatives such as