Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Blood in the Water (film) triggered a nationwide panic. It also details how scientists views on sharks and the threat they posed to humans changed in the wake of the attacks. Blood in the Water (film) Blood in the Water is a television film that aired on the Discovery Channel in 2009. It was directed by Richard Bedser. It is based on a true-life series of shark attacks that became the inspiration for Peter Benchley's novel "Jaws". It was the season premiere of Shark Week on August 2 for the 2009 season. "Blood in the Water" tells the story of a series of shark attacks,