Protein signalling in heart development Protein signalling in heart development The heart is the first functional organ in a vertebrate embryo. There are 5 stages to heart development. Specification of cardiac precursor cells: The lateral plate mesoderm delaminates to form two layers: the dorsal somatic (parietal) mesoderm and the ventral splanchnic (visceral) mesoderm. The heart precursor cells come from the two regions of the splanchnic mesoderm called the cardiogenic mesoderm. These cells can differentiate into endocardium which lines the heart chamber and valves and the myocardium which forms the musculature of the ventricles and the atria. The heart cells are specified in anterior mesoderm by
How Many Licks? Kim and Sisqó, who are credited under their legal names (Kimberly Jones and Mark Andrews). Sisqó wrote the song's hook and contributed verses. The vocals were recorded by Dave Wade and Stephen Dent at Daddy's House Recording Studios in New York City and Trans Continental Studios in Orlando, with Ed Raso mixing the audio. "How Many Licks?" was released as the second single from Lil' Kim's second album, "The Notorious K.I.M." (2000), as a 12-inch single and CD single by Atlantic Records and Queen Bee Entertainment. A remix by American production duo the Neptunes was also made available, with vocals