Exercise physiology loss of integrity to the blood brain barrier. Hyperthermia also can lower cerebral blood flow, and raise brain temperature. Researchers once attributed fatigue to a build-up of lactic acid in muscles. However, this is no longer believed. Rather, lactate may stop muscle fatigue by keeping muscles fully responding to nerve signals. The available oxygen and energy supply, and disturbances of muscle ion homeostasis are the main factor determining exercise performance, at least during brief very intense exercise. Each muscle contraction involves an action potential that activates voltage sensors, and so releases Ca ions from the muscle fibre’s sarcoplasmic reticulum. The
What's Easy for Two Is Hard for One What's Easy for Two Is Hard for One "What's Easy for Two Is Hard for One" (also known as "What's Easy for Two Is So Hard for One") is a song written and produced by Smokey Robinson and released as a single by singer Mary Wells for the Motown label. In this song, the narrator is longing for a longtime partnership with a suitor and constantly begs the man to "take her to the preacher man" in hopes the couple does "what should be done" because "what two can easily do is so hard to be done by one". Released