Muscarinic antagonist brain, involving both increased levels of acetylcholine and degeneration of dopaminergic pathways (nigrostriatal pathway). Thus, in parkinsonism there is decreased level of dopaminergic activity. One method of balancing the neurotransmitters is through blocking central cholinergic activity using muscarinic receptor antagonists. Atropine acts on the M2 receptors of the heart and antagonizes the activity of acetylcholine. It causes tachycardia by blocking vagal effects on the sinoatrial node. Acetylcholine hyperpolarizes the sinoatrial node, which is overcome by MRA and thus increases the heart rate. If atropine is given by intramuscular or subcutaneous injection, it causes initial bradycardia. This is because by i.m/s.c
Node influence metric probabilities. The accessibility has been shown to reveal community structure in urban networks, corresponds to the number of nodes which can be visited in a defined time period, and is predictive of the outcome of epidemiological SIR model spreading processes on networks with large diameter and low density. The expected force measures node influence from an epidemiological perspective. It is the expected value of the force of infection generated by the node after two transmissions. The expected force of a node formula_4 is given by where the sum is taken over the set formula_9 of all possible transmission clusters resulting