Red blood cell macrophages and subsequent phagocytosis in the mononuclear phagocyte system (spleen, liver and lymph nodes), thus removing old and defective cells and continually purging the blood. This process is termed eryptosis, red blood cell programmed cell death. This process normally occurs at the same rate of production by erythropoiesis, balancing the total circulating red blood cell count. Eryptosis is increased in a wide variety of diseases including sepsis, haemolytic uremic syndrome, malaria, sickle cell anemia, beta-thalassemia, glucose-6-phosphate dehydrogenase deficiency, phosphate depletion, iron deficiency and Wilson's disease. Eryptosis can be elicited by osmotic shock, oxidative stress, energy depletion as well as a
The Blood Cell The Blood Cell The Blood Cell is a BBC Books original novel written by James Goss and based on the long-running British science fiction television series "Doctor Who". It features the Twelfth Doctor and Clara Oswald. The book was released on 11 September 2014 along with "Silhouette" and "The Crawling Terror". "The Blood Cell" gained generally positive reviews, calling it an "effective chiller". Most of them commented the unusual way of narration from the first-person perspective of the administrator of the prison in which the book is set known as the Governor. More grim and darker tone is also noted.