Valerian (herb) some affinity for the GABA receptor, a class of receptors on which benzodiazepines are known to act. Valeric acid, which is responsible for the typical odor of mostly older valerian roots, does not have any sedative properties. Valeric acid is related to valproic acid, a widely prescribed anticonvulsant; valproic acid is a derivative of valeric acid. Valerian also contains isovaltrate, which has been shown to be an inverse agonist for adenosine A receptor sites. This action likely does not contribute to the herb's possible sedative effects, which would be expected from an agonist, rather than an inverse agonist, at this
Valerian Kuybyshev Valerian Kuybyshev Valerian Vladimirovich Kuybyshev (; – 25 January 1935) was a Russian revolutionary, Red Army officer, and prominent Soviet politician. Kuybyshev was born in Omsk in the Russian Empire on . He studied at the Omsk Military Cadet School. He joined the Bolshevik faction of the Russian Social Democratic Labour Party in 1904. The following year, he entered a military medical academy, but was expelled in 1906 for controversial political activities. Between 1906 and 1914, Kuybyshev performed subversive activities for the Bolsheviks throughout the Empire, for which he was exiled to Narym in Siberia where—together with Yakov Sverdlov—he set