Gay-Lussac's law gases and the gaseous products can be expressed in simple whole numbers. For example, Gay-Lussac found that 2 volumes of hydrogen and 1 volume of oxygen would react to form 2 volumes of gaseous water. Based on Gay-Lussac's results, Amedeo Avogadro theorized that, at the same temperature and pressure, equal volumes of gas contain equal numbers of molecules (Avogadro's law). This hypothesis meant that the previously stated result could also be expressed as The law of combining gases was made public by Joseph Louis Gay-Lussac in 1808. Avogadro's hypothesis, however, was not initially accepted by chemists until the Italian chemist
Amedeo Avogadro often referred to as the Loschmidt number in German-speaking countries (Loschmidt constant now has another meaning). Avogadro's Law states that the relationship between the masses of the same volume of all gases (at the same temperature and pressure) corresponds to the relationship between their respective molecular weights. Hence, the relative molecular mass of a gas can be calculated from the mass of sample of known volume. Avogadro developed this hypothesis after Joseph Louis Gay-Lussac had published in 1808 his law on volumes (and combining gases). The greatest problem Avogadro had to resolve was the confusion at that time regarding atoms