Molecular models of DNA simulations that are very important to understand how DNA functions "in vivo". From the very early stages of structural studies of DNA by X-ray diffraction and biochemical means, molecular models such as the Watson-Crick nucleic acid double helix model were successfully employed to solve the 'puzzle' of DNA structure, and also find how the latter relates to its key functions in living cells. The first high quality X-ray diffraction patterns of A-DNA were reported by Rosalind Franklin and Raymond Gosling in 1953. Rosalind Franklin made the critical observation that DNA exists in two distinct forms, A and B, and produced
Rudolf Signer from the Thymus of calves, of which he took 15 grams of extraordinarily pure DNA to London. In England he gave it to various scientists, among them Maurice Wilkins, in order to promote research in the field. The analysis of X ray images of these DNA samples in Wilkins' laboratory allowed James Watson and Francis Crick to discover the double-helix structure of DNA. Rests of the DNA which Signer brought to England, survive today in the collection of King's College, London. Over 250 of Signer's scientific writings were published during his lifetime. The Lavoisier Medal was awarded to him for