Glycogen storage disease type 0 glycogen primer. Its action is highly regulated by a mechanism of phosphorylation and dephosphorylation and modulated by counter-regulatory hormones including insulin, epinephrine, and glucagon. Mutations in the gene for liver glycogen synthetase (GYS2, 138571) result in decreased or absent activity of liver glycogen synthetase and moderately decreased amounts of structurally normal glycogen in the liver. Mutational studies of patients with glycogen-storage disease type 0 do not demonstrate correlations between genotype and phenotype. [3] A different gene (GYS1, 138570) encodes muscle glycogen synthetase, which has normal activity in patients with glycogen-storage disease type 0A. In the early stages of fasting, the
Metropolitan Stores wholly owned Canadian subsidiary of Metropolitan Stores Ltd. to investment bankers James Richardson & Sons Ltd. of Winnipeg, Manitoba for approximately $19 million in cash, which returned the company to 100 per cent Canadian ownership. The agreement brought 86 stores and one warehouse located mainly in Ontario, Quebec and Winnipeg with annual sales in excess of $20 million and an annual profit after taxes of more than $1 million. Following the purchase, James Richardson & Sons transferred the business of Metropolitan Stores Ltd. to a newly formed Canadian corporation that became known as Metropolitan Stores of Canada Ltd. Two months