Fluorine in annual revenue. Due to the danger from direct hydrocarbon–fluorine reactions above −150 °C (−240 °F), industrial fluorocarbon production is indirect, mostly through halogen exchange reactions such as Swarts fluorination, in which chlorocarbon chlorines are substituted for fluorines by hydrogen fluoride under catalysts. Electrochemical fluorination subjects hydrocarbons to electrolysis in hydrogen fluoride, and the Fowler process treats them with solid fluorine carriers like cobalt trifluoride. Halogenated refrigerants, termed Freons in informal contexts, are identified by R-numbers that denote the amount of fluorine, chlorine, carbon, and hydrogen present. Chlorofluorocarbons (CFCs) like R-11, R-12, and R-114 once dominated organofluorines, peaking in production
Biological aspects of fluorine Biological aspects of fluorine Biological aspects of fluorine describes the effects of fluorine-containing compounds with life. Fluorine (F) itself is very rare in everyday life, but hundreds of fluorine-containing compounds occur as minerals, medicines, pesticides, and materials. Naturally occurring organofluorine compounds are extremely rare. Nonetheless, twenty percent of all commercialized pharmaceuticals contain fluorine, examples being Lipitor and Prozac. Manmade fluorinated compounds have also played a role in several noteworthy environmental concerns. Chlorofluorocarbons, once major components of numerous commercial aerosol products, have proven damaging to Earth's ozone layer and resulted in the wide-reaching Montreal Protocol (though in truth the chlorine in