Tympanic membrane retraction caused by erosion of the ossicles (hearing bones). Discharge from the ear often indicates that the retraction pocket has developed into a cholesteatoma. Three factors must occur for the tympanic membrane to become retracted: When gas pressure within the middle ear is less than atmospheric pressure, the eardrum can become sucked into the middle ear space. This is caused by inadequate opening of the Eustachian tube and absorption of air from the middle ear space. People with a patulous Eustachian tube may also cause negative middle ear pressure by repeatedly sniffing to try to keep their Eustachian tube closed. The
Biological membrane fatty acid composition in accordance with differing temperatures. In animal cells, membrane fluidity is modulated by the inclusion of the sterol cholesterol. This molecule is present in especially large amounts in the plasma membrane, where it constitutes approximately 20% of the lipids in the membrane by weight. Because cholesterol molecules are short and rigid, they fill the spaces between neighboring phospholipid molecules left by the kinks in their unsaturated hydrocarbon tails. In this way, cholesterol tends to stiffen the bilayer, making it more rigid and less permeable. For all cells, membrane fluidity is important for many reasons. It enables membrane