Insulin oscillation oscillations. The insulin oscillations are generated by pulsatile release of the hormone from the pancreas. Insulin originates from beta cells located in the islets of Langerhans. Since each islet contains up to 2000 beta cells and there are one million islets in the pancreas it is apparent that pulsatile secretion requires sophisticated synchronization both within and among the islets of Langerhans. Pulsatile insulin secretion from individual beta cells is driven by oscillation of the calcium concentration in the cells. In beta cells lacking contact, the periodicity of these oscillations is rather variable (2-10 min). However, within an islet of Langerhans
Ryan Langerhans of the independent Atlantic League. Langerhans was signed to a minor league contract and assigned to the Buffalo Bisons again on August 22, 2013. When the Bisons season ended, Langerhans asked for and received his release, and returned to the Sugar Land Skeeters for their playoff run. On September 26, Langerhans again signed with the Blue Jays. This time a major league contract as the Blue Jays were short on position players. He became a free agent on October 8, 2013. He hit a game-winning home run against J.P. Howell on August 7, 2009, with two outs in the bottom