Light effects on circadian rhythm collected by rod cells and cone cells and the retinal ganglion cells (RGCs), or it is directly collected by these RGCs. The RGCs use the photopigment melanopsin to absorb the light energy. Specifically, this class of RGCs being discussed is referred to as "intrinsically photosensitive," which just means they are sensitive to light. There are five known types of intrinsically photosensitive retinal ganglion cells (ipRGCs): M1, M2, M3, M4, and M5. Each of these differently ipRGC types have different melanopsin content and photosensitivity. These connect to amacrine cells in the inner plexiform layer of the retina. Ultimately, via this retinohypothalamic
Tetrachromacy the brain would respond if presented with a new color channel. Mice, which normally have only two cone pigments, can be engineered to express a third cone pigment, and appear to demonstrate increased chromatic discrimination, arguing against some of these obstacles; however, the original publication's claims about plasticity in the optic nerve have also been disputed. Humans cannot see ultraviolet light directly because the lens of the eye blocks most light in the wavelength range of 300–400 nm; shorter wavelengths are blocked by the cornea. The photoreceptor cells of the retina are sensitive to near ultraviolet light, and people lacking