Toxicodynamics into awareness by Our Stolen Future by Theo Colborn. Endocrine disrupting chemicals are known to accumulate in body tissue and are highly persistent in the environment. Many toxicants are known EDCs including pesticides, phthalates, phytoestrogens, some industrial/commercial products, and pharmaceuticals. These chemicals are known to cause endocrine disruption via a few different mechanisms. While the mechanism associated with the thyroid hormone receptor is not well understood, two more established mechanisms involve the inhibition of the androgen receptor and activation of the estrogen receptor. Certain toxicants act as endocrine disruptors by interacting with the androgen receptor. DDE is one example of
GreenScreen for Safer Chemicals GreenScreen for Safer Chemicals The GreenScreen for Safer Chemicals is a transparent, open standard for assessing chemical hazard that supports alternatives assessment for toxics use reduction through identifying chemicals of concern and safer alternatives. It is used by researchers, product formulators and certifiers in a variety of industries, including building products, textiles, apparel, and consumer products. The GreenScreen prioritizes the avoidance of substances with a high hazard as a carcinogen, mutagen, reproductive toxicant or developmental toxicant or endocrine disruptor or that are a persistent, bioaccumulative and toxic substance (PBT). The GreenScreen protocol is published in a Guidance document that is