History of diabetes further clarified in 1921, when Sir Frederick Grant Banting and Charles Herbert Best repeated the work of Von Mering and Minkowski, and went further to demonstrate they could reverse induced diabetes in dogs by giving them an extract from the pancreatic islets of Langerhans of healthy dogs. The islets of Langerhans was discovered in 1869 by an anatomist named Paul Langerhans. He identified the keys cells in the pancreas which produce the main substance that controls glucose levels in the body. Banting, Best, and colleagues (especially the chemist Collip) went on to purify the hormone insulin from bovine pancreases at
Ryan Langerhans RBIs, and 19 stolen bases. In 2000, Langerhans was assigned to the Class-A Advanced Myrtle Beach Pelicans of the Carolina League. He appeared in 116 games with the Pelicans and batted .212 with 14 doubles, 7 triples, 6 home runs, 37 RBIs, and 25 stolen bases. Langerhans's 7 triples was tied for third most in the league with Choo Freeman (7), was and behind Damione Merriman (9), and Chone Figgins (14). Langerhans continued playing with the Class-A Advanced Myrtle Beach Pelicans in 2001. He batted .287 with 30 doubles, 3 triples, 7 home runs, 48 RBIs, and 22 stolen bases.