Asphyxiant gas can smell the odorants, and assigning a different smell to each gas may be impractical. Another difficulty is that most odorants (e.g., the thiols) are chemically reactive. This is not a problem with natural gas intended to be burned as fuel, which is routinely odorized, but a major use of asphyxiants such as nitrogen, helium, argon and krypton is to protect reactive materials from the atmosphere. The dangers of excess concentrations of nontoxic gases has been recognized for centuries within the mining industry. The concept of black damp (or "stythe") reflects an understanding that certain gaseous mixtures could lead to
Carbon dioxide in Earth's atmosphere may have been higher, with estimated partial pressure as large as , because there was no bacterial photosynthesis to reduce the gas to carbon compounds and oxygen. Methane, a very active greenhouse gas which reacts with oxygen to produce and water vapor, may have been more prevalent as well, with a mixing ratio of 10 (100 parts per million by volume). Though water is responsible for most (about 36-70%) of the total greenhouse effect, the role of water vapor as a greenhouse gas depends on temperature. On Earth, carbon dioxide is the most relevant, direct anthropologically influenced greenhouse gas. Carbon