Cone of light an ear disorder, as it could be due to the slope of the tympanic membrane or the shape of the ear canal. However, distortions in the cone of light can also be a sign of increased inner ear pressure or otitis media. Cone of light The cone of light, or light reflex, is a visible phenomenon which occurs upon examination of the tympanic membrane with an otoscope. Shining light on the tympanic membrane causes a cone-shaped reflection of light to appear in the anterior inferior quadrant. This corresponds to the 4 o'clock to 5 o'clock position in the right eardrum
Translocase of the inner membrane modified complex containing Tim12, on the outer surface of the TIM22 complex. Tim12 is membrane bound and thus may act as a linker molecule docking Tim9 and Tim10 to the face of the TIM22 complex. The carrier preprotein is then inserted into the inner mitochondrial membrane in a potential-dependent fashion. The membrane potential is necessary for both insertion of the precursor into the carrier translocase and lateral release of the protein into the lipid phase of the inner mitochondrial membrane, which completes protein translocation. However this membrane potential-dependent process takes place in absence of ATP-driven machinery. TIM17A; TIMM17A; TIMM17B; TIMM22;