Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
Human vestigiality dorsi to the long head of the triceps brachii. It is notable due to its well developed character in other apes and monkeys, where it is an important climbing muscle, namely the dorsoepitrochlearis brachii. This muscle is found in ≈5% of humans. The plantaris muscle is composed of a thin muscle belly and a long thin tendon. The muscle belly is approximately long, and is absent in 7–10% of the human population. It has some weak functionality in moving the knee and ankle but is generally considered redundant and is often used as a source of tendon for grafts. The