Estradiol for tissue of the reproductive organs, supporting the lining of the vagina, the cervical glands, the endometrium, and the lining of the fallopian tubes. It enhances growth of the myometrium. Estradiol appears necessary to maintain oocytes in the ovary. During the menstrual cycle, estradiol produced by the growing follicles triggers, via a positive feedback system, the hypothalamic-pituitary events that lead to the luteinizing hormone surge, inducing ovulation. In the luteal phase, estradiol, in conjunction with progesterone, prepares the endometrium for implantation. During pregnancy, estradiol increases due to placental production. The effect of estradiol, together with estrone and estriol, in pregnancy
Menstrual cycle by women during the peak of their fertility in the menstrual cycle. Moreover, women may demonstrate preference for men with a scent that indicates developmental stability. With regard to women's smell across the cycle, some evidence indicates that men use olfactory cues in order to know if a woman is ovulating. Using a rating of women's odors, women who are ovulating have been rated as more attractive by men. Men demonstrate preferences for the scent of fertile women. Preferences for facial features in mates can also change across the cycle. There has been no difference found in preference for long-term