Tympanic membrane retraction over the surface and move out along the ear canal. Even if migration along the ear canal is blocked, new cells continue to grow so the surface of the eardrum becomes larger. This process of proliferation and migration can result in enlargement of a retraction pocket so that the eardrum expands and grows deeper into the ear. The majority of tympanic membrane retractions remain stable for long periods of time, or may even resolve spontaneously so that eardrum becomes normal again. Not all retractions are able to resolve even if middle ear pressure normalizes, as the retracted segment may become
Translocase of the inner membrane modified complex containing Tim12, on the outer surface of the TIM22 complex. Tim12 is membrane bound and thus may act as a linker molecule docking Tim9 and Tim10 to the face of the TIM22 complex. The carrier preprotein is then inserted into the inner mitochondrial membrane in a potential-dependent fashion. The membrane potential is necessary for both insertion of the precursor into the carrier translocase and lateral release of the protein into the lipid phase of the inner mitochondrial membrane, which completes protein translocation. However this membrane potential-dependent process takes place in absence of ATP-driven machinery. TIM17A; TIMM17A; TIMM17B; TIMM22;