Light effects on circadian rhythm collected by rod cells and cone cells and the retinal ganglion cells (RGCs), or it is directly collected by these RGCs. The RGCs use the photopigment melanopsin to absorb the light energy. Specifically, this class of RGCs being discussed is referred to as "intrinsically photosensitive," which just means they are sensitive to light. There are five known types of intrinsically photosensitive retinal ganglion cells (ipRGCs): M1, M2, M3, M4, and M5. Each of these differently ipRGC types have different melanopsin content and photosensitivity. These connect to amacrine cells in the inner plexiform layer of the retina. Ultimately, via this retinohypothalamic
Giant retinal ganglion cells Giant retinal ganglion cells Giant retinal ganglion cells are photosensitive ganglion cells with large dendritic trees discovered in the human and macaque retina by Dacey "et al". (2005). Giant retinal ganglion cells contain a photo-pigment, melanopsin, allowing them to respond directly to light. They also receive connections from rods and cones, allowing them to encode colour and spatial information. Dacey "et al". found the giants' receptive field sizes to be about three times the diameter of those of parasol ganglion cells. There are only about 3000 giant retinal ganglion cells in each retina, comprising about 0.2% of the total number