Sickle cell disease other genetic diseases) among African Americans compared to West Africans. Another factor that limits the spread of sickle cell genes in North America is the relative absence of polygamy, which allows affected males to continue to produce many children with multiple partners. The loss of red blood cell elasticity is central to the pathophysiology of sickle cell disease. Normal red blood cells are quite elastic, which allows the cells to deform to pass through capillaries. In sickle cell disease, low oxygen tension promotes red blood cell sickling and repeated episodes of sickling damage the cell membrane and decrease the cell's
Blood Red Horse Blood Red Horse Blood Red Horse is a 2004 young adult historical novel by author K M Grant. The book was published in 2004 by Puffin Books and in the US in 2005 by Walker Children's. "Blood Red Horse" is the first novel in the De Granville Trilogy and was followed by the books "Green Jasper" and "Blaze of Silver". In 2006 the audiobook version of "Blood Red Horse" won an AudioFile Earphones Award and in 2007 was one of YALSA's recommended audiobooks for 2007. "Blood Red Horse" follows Will and Ellie, two young teens growing up during the time