Max Perutz the onset of Huntington disease is related to the number of glutamine repeats as they bind to form what he called a polar zipper. During the early 1950s, while Watson and Crick were determining the structure of deoxyribonucleic acid (DNA), they made use of unpublished X-ray diffraction images taken by Rosalind Franklin, shown at meetings and shared with them by Maurice Wilkins, and of Franklin's preliminary account of her detailed analysis of the X-ray images included in an unpublished 1952 progress report for the King's College laboratory of Sir John Randall. Randall and others eventually criticised the manner in which
Triple-stranded DNA Triple-stranded DNA Triple-stranded DNA (also known as H-DNA or Triplex-DNA) is a DNA structure in which three oligonucleotides wind around each other and form a triple helix. In triple stranded-DNA, one strand binds to a B-form DNA (Watson–Crick base-pairing) through Hoogsteen base pair or reversed Hoogsteen hydrogen bonds. A thymine (T) nucleobase can bind to a Watson–Crick base-pairing of T-A by a Hoogsteen hydrogen bond. The thymine attaches to the adosine (A) of the origin double stranded DNA to create a T-A*T base-triplet. In acidic conditions, a protonated cytosine, represented as C+, can form a base-triplet with a C-G pair