Allergic inflammation immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema. The late phase of a Type 1 reaction (which develops 8–12
Allergic transfusion reaction from a donor who has allergies, followed by antigen exposure. An allergic transfusion reaction is a type of transfusion reaction that is defined according to the Center for Disease Control (CDC) as: An allergic transfusion reaction is diagnosed if two or more of the following occur within 4 hours of cessation of transfusion: A probable diagnosis results if any one of the following occurring within 4 hours of cessation of transfusion: Treatment of an allergic transfusion reaction is to immediate stop the transfusion. If the only symptoms are mild (i.e., hives and itching), the patient may be treated with an