Pharmacokinetics of progesterone concentrations was around 4 hours and the elimination half-life was in the range of 30 to 40 hours. The venous blood levels observed were very low. Because progesterone is a lipophilic and hydrophobic compound, it is not absorbed efficiently by the skin. Moreover, because the body produces about 25 mg progesterone per day on average during the luteal phase, around 50% of the body would need to be used as a surface of absorption to deliver a similar quantity of progesterone. As such, the transdermal route cannot easily achieve adequate circulating progesterone levels, and this makes transdermal progesterone impractical for
Menstrual disorder Menstrual disorder A menstrual disorder is an abnormal condition in a woman's menstrual cycle. Disorders of ovulation include oligoovulation and anovulation: "Polymenorrhea" is the medical term for cycles with intervals of 21 days or fewer. "Irregular menstruation" is where there is variation in menstrual cycle length of more than approximately eight days for a woman. The term "metrorrhagia" is often used for irregular menstruation that occurs between the expected menstrual periods. "Oligomenorrhea" is the medical term for infrequent, often light menstrual periods (intervals exceeding 35 days). "Amenorrhea" is the absence of a menstrual period in a woman of reproductive age.