Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Blood & Water Blood & Water Blood & Water was a 2003 five-issue horror comic book limited series written by Judd Winick and illustrated by Tomm Coker, with covers by Brian Bolland. It was published by Vertigo Comics from March to July, 2003, with cover dates of May to September, 2003. It stars Adam Heller, a young man with terminal illness whose friends offer to save his life, but through an unusual means that may come with a price. San Francisco resident Adam Heller is a young man who had a bright future ahead of him. But a case of food poisoning when