Gonadal dysgenesis If a single or combination of these genes are mutated or deleted, downstream signalling is disrupted, leading to malformation of male external genitalia. SRY acts on gene SOX9 which drives Sertoli cell formation and testis differentiation. An absence in SRY causes SOX9 to not be expressed at the appropriate time or concentration, leading to a deficiency in testosterone and Anti-Müllerian hormone production. Inadequate levels of testosterone and Anti-Müllerian hormone disrupts the development of Wolffian ducts and internal genitalia that are key to male reproductive tract development. The lack of the male associated steroid hormones drives Müllerian duct development and perusal
Asia Pacific Coalition on Male Sexual Health Asia Pacific Coalition on Male Sexual Health The Asia Pacific Coalition on Male Sexual Health, also known as APCOM, is a network of non-profit organizations which share the mission of improving male sexual health in South Asia, East Asia, and the Pacific Islands. APCOM was launched in July 2007 after delegates to the Delhi 2006 International Consultation on Male Sexual Health and HIV in Asia and the Pacific identified a need for more organization in the field of male sexual health. APCOM was founded as an autonomous, regional coalition of citizen groups, government representatives, funders, technical consultants and the United