Myringoplasty perforation and a small part should also extend over the posterior canal wall. The tympanomeatal flap is then replaced. The temporal fascia is harvested. An incision is made to raise medial meatal skin with tympanic membrane epithelium. The graft is placed on the outer surface of the tympanic membrane and a slit is made to tuck it under the handle of malleus. The ear is packed with gelfoam and antibiotics, and the incision is closed. Finally mastoid dressing is performed. Myringoplasty Myringoplasty is the closure of the perforation of pars tensa of the tympanic membrane. When myringoplasty is combined with
Translocase of the outer membrane TOMM22, TOMM40, TOM7, TOMM7 Translocase of the outer membrane The translocase of the outer membrane (TOM) is a complex of proteins found in the outer mitochondrial membrane of the mitochondria. It allows movement of proteins through this barrier and into the intermembrane space of the mitochondrion. Most of the proteins needed for mitochondrial function are encoded by the nucleus of the cell. The outer membrane of the mitochondrion is impermeable to large molecules greater than 5000 Daltons. The TOM works in conjunction with the translocase of the inner membrane (TIM) to translocate proteins into the mitochondrion. Many of the proteins