Human skin color effects of tanning. Around the same age, women experience darkening of some areas of their skin. Human skin color fades with age. Humans over the age of thirty experience a decrease in melanin-producing cells by about 10% to 20% per decade as melanocyte stem cells gradually die. The skin of face and hands has about twice the amount of pigment cells as unexposed areas of the body, as chronic exposure to the sun continues to stimulate melanocytes. The blotchy appearance of skin color in the face and hands of older people is due to the uneven distribution of pigment cells
Pigment carmine was popular in Europe, blue remained an exclusive color, associated with wealth and status. The 17th-century Dutch master Johannes Vermeer often made lavish use of lapis lazuli, along with carmine and Indian yellow, in his vibrant paintings. The earliest known pigments were natural minerals. Natural iron oxides give a range of colors and are found in many Paleolithic and Neolithic cave paintings. Two examples include Red Ochre, anhydrous FeO, and the hydrated Yellow Ochre (FeOHO). Charcoal—or carbon black—has also been used as a black pigment since prehistoric times. Two of the first synthetic pigments were white lead (basic lead