Endocrine disruptor to have committed scientific misconduct. Found in many household and industrial products, endocrine disruptors are substances that "interfere with the synthesis, secretion, transport, binding, action, or elimination of natural hormones in the body that are responsible for development, behavior, fertility, and maintenance of homeostasis (normal cell metabolism)." They are sometimes also referred to as hormonally active agents, endocrine disrupting chemicals, or endocrine disrupting compounds. The variety of terms used to describe these substances reflects not only a range of meanings but a range of connotations, with "endocrine disruptor" emphasizing harmful effects, while "hormonally active agent" or "xenohormone" are more neutral,
Multiple endocrine neoplasia 40 years of age. There is significant intra- and inter-familial variability in the age of onset, severity of disease, and tumor types. Despite numerous studies, no genotype-phenotype correlations have been established, suggesting that unknown genetic and environmental modifiers are involved in the expression of the MEN1 phenotype. Multiple Endocrine Neoplasia type 1 (MEN1) is a rare hereditary endocrine cancer syndrome characterized primarily by tumors of the parathyroid glands (95% of cases), endocrine gastroenteropancreatic (GEP) tract (30-80% of cases), and anterior pituitary (15-90% of cases). Other endocrine and non-endocrine neoplasms including adrenocortical and thyroid tumors, visceral and cutaneous lipomas, meningiomas, facial