Glycogen synthase expression of the muscle isozyme and not the liver isozyme. However, muscle-specific glycogen synthase activation may lead to excessive accumulation of glycogen, leading to damage in the heart and central nervous system following ischemic insults. The reaction is highly regulated by allosteric effectors such as glucose-6-phosphate (activator) and by phosphorylation reactions (deactivating). Glucose-6-phosphate allosteric activating action allows glycogen synthase to operate as a glucose-6-phosphate sensor. The inactivating phosphorylation is triggered by the hormone glucagon, which is secreted by the pancreas in response to decreased blood glucose levels. The enzyme also cleaves the ester bond between the C1 position of glucose
Metropolitan Stores wholly owned Canadian subsidiary of Metropolitan Stores Ltd. to investment bankers James Richardson & Sons Ltd. of Winnipeg, Manitoba for approximately $19 million in cash, which returned the company to 100 per cent Canadian ownership. The agreement brought 86 stores and one warehouse located mainly in Ontario, Quebec and Winnipeg with annual sales in excess of $20 million and an annual profit after taxes of more than $1 million. Following the purchase, James Richardson & Sons transferred the business of Metropolitan Stores Ltd. to a newly formed Canadian corporation that became known as Metropolitan Stores of Canada Ltd. Two months