Exercise physiology loss of integrity to the blood brain barrier. Hyperthermia also can lower cerebral blood flow, and raise brain temperature. Researchers once attributed fatigue to a build-up of lactic acid in muscles. However, this is no longer believed. Rather, lactate may stop muscle fatigue by keeping muscles fully responding to nerve signals. The available oxygen and energy supply, and disturbances of muscle ion homeostasis are the main factor determining exercise performance, at least during brief very intense exercise. Each muscle contraction involves an action potential that activates voltage sensors, and so releases Ca ions from the muscle fibre’s sarcoplasmic reticulum. The
Stiffness diagonal terms), the corresponding DOF is left free while the remaining should be constrained. Under such a condition, the above equation can be used to obtain the direct-related stiffness for the degree of freedom which is unconstrained. The ratios between the reaction forces (or moments) and the produced deflection are the coupling stiffnesses. A description including all possible stretch and shear parameters is given by the elasticity tensor. The inverse of stiffness is "flexibility" or "compliance", typically measured in units of metres per Newton. In rheology, it may be defined as the ratio of strain to stress, and so take