Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Water organ England; Cornelius Drebbel built one for King James I (Harstoffer, 1651), and Salomon de Caus built several at Richmond while in the service of Prince Henry. There was one in Bagnigge Vale, London, the summer home of Nell Gwynn (1650–87), and Henry Winstanley (1644–1703), the designer of the Eddystone Lighthouse, is thought to have built one at his home in Saffron Walden, Essex. After the marriage of Princess Elizabeth to the Elector Palatine Prince Friedrich V, de Caus laid out for them the gardens at Heidelberg Castle which became famous for their beautiful and intricate waterworks. A water organ survives