Rimantadine antagonistic properties and is used as an antiparkinsonic drug (i.e., in the treatment of Parkinson's disease). However, in general, neither rimantadine nor amantadine is a preferred agent for this therapy and would be reserved for cases of the disease that are less responsive to front-line treatments. Taking paracetamol (acetaminophen, Tylenol) or acetylsalicylic acid (aspirin) while taking rimantadine is known to reduce the body's uptake of rimantadine by approximately 12%. Cimetidine also affects the body's uptake of rimantadine. Rimantadine can produce gastrointestinal and central nervous system adverse effects. Approximately 6% of patients (compared to 4% of patients taking a placebo) reported
Technetium (99mTc) medronic acid Technetium (99mTc) medronic acid Technetium (Tc) medronic acid (MDP) is a pharmaceutical product used in nuclear medicine to localize bone metastases as well as other diseases that can alter the natural turn-over in the bone by bone scintigraphy. The drug is a complex of medronic acid, the simplest bisphosphonate, with technetium-99m (Tc), a radionuclide that emits gamma rays. The exact structure of the complex is not known. Tc-MDP must be prepared in a radiopharmacy. It is usually supplied as a "cold kit" to which radioactive Tc from a generator is added. Kit composition may vary between suppliers, but contents typically