Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Blood in the Water match and spat at the Russians. To avoid a riot, police entered the arena and shepherded the crowd away. Pictures of Zádor's injuries were published around the world, leading to the "Blood in the Water" moniker. Reports that the water in the pool turned red were, however, an exaggeration. Zádor said his only thought was whether he would be able to play the next match. The referees stopped the match; Hungary was declared the winner since they had been leading. Hungary then beat Yugoslavia 2–1 in the final to win their fourth Olympic gold medal. Zádor's injury would force him to