Rosalind Franklin and DNA best evidence for the structure of DNA. For the discovery of the correct chemical structure of DNA, the Nobel Prize in Physiology or Medicine 1962 was shared by her colleagues and close researchers James Watson, Francis Crick and Maurice Wilkins; she died four years earlier in 1958 making her inelligible for the award. Rosalind Franklin joined the King's College London in January 1951 to work on the crystallography of DNA. By the end of that year, she established two important facts: one is that phosphate groups, which are the molecular backbone for the nucleotide chains, lie on the outside (it
Molecular models of DNA omit both water and ions dynamically bound to B-DNA, and are thus less useful for understanding the dynamic behaviors of B-DNA "in vivo". The physical and mathematical analysis of X-ray and spectroscopic data for paracrystalline B-DNA is thus far more complex than that of crystalline, A-DNA X-ray diffraction patterns. The paracrystal model is also important for DNA technological applications such as DNA nanotechnology. Novel methods that combine X-ray diffraction of DNA with X-ray microscopy in hydrated living cells are now also being developed. There are various uses of DNA molecular modeling in Genomics and Biotechnology research applications, from DNA repair