Vein limbs. The Thebesian veins within the myocardium of the heart are valveless veins that drain directly into the chambers of the heart. The coronary veins all empty into the coronary sinus which empties into the right atrium. The dural venous sinuses within the dura mater surrounding the brain receive blood from the brain and also are a point of entry of cerebrospinal fluid from arachnoid villi absorption. Blood eventually enters the internal jugular vein. "Phlebology" is the medical specialty devoted to the diagnosis and treatment of venous disorders. A medical specialist in phlebology is termed a phlebologist. A related image
Blood–brain barrier more likely, aggravated) by a breakdown in the blood–brain barrier. Cerebral edema is the accumulation of excess water in the extracellular space of the brain, which can result when hypoxia causes the blood–brain barrier to open. Many neurodegenerative diseases including synucleinopathies such as Parkinson's, and tauopathies such as Alzheimer's are thought to result from seeded misfolding from pathological extracellular protein variants known as prions. This prion-like hypothesis is gaining support in numerous studies in vitro and involving in vivo intracerebral injection of brain lysates, extracted protein (tau, alpha-synuclein) and synthetically generated fibers in alpha-synucleinopathies. These proteins are also detectable in