Colour centre This is more important for perceiving the colour of objects and pictures. The double-opponent cells are receptive to opposite inputs from different cone cells in the retina. This is ideal for identifying contrasting colours, such as red and green. [1] Double-opponent cells are particularly important in computing local cone ratios from visual information from their receptive fields. Single opponent colour-sensitive neurons can be divided into two categories depending on the signals they receive from the cone cells: L-M neurons and S/(L+M) neurons. The three types of cone cells, small (S), medium (M), and long (L), detect different wavelengths across the
Gene therapy of the human retina and expressing the therapeutic DNA sequence. Since the cells of the retina are non-dividing, AAV continues to persist and provide expression of the therapeutic DNA sequence over a long time period that can last several years. AAV is capable of transducing multiple cell types within the retina. AAV serotype 2, the most well-studied type of AAV, is commonly administered in one of two routes: intravitreal or subretinal. Using the intravitreal route, AAV is injected in the vitreous humor of the eye. Using the subretinal route, AAV is injected underneath the retina, taking advantage of the potential space between the photoreceptors