Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
Acid test (gold) to assess the liquidity of a business. The use of the term "acid test" for experiences with the psychedelic drug LSD was popularised by the Merry Pranksters, and derives from the drug's common name, "acid". Acid test (gold) An acid test is any qualitative chemical or metallurgical assay which uses acid; most commonly, and historically, the use of a strong acid to distinguish gold from base metals. Figuratively, acid test is any definitive test for some attribute, e.g. of a person's character, or of the performance of product. Testing for gold with acid focuses on the fact that gold is