Antibiotic use in dentistry of bacteria from advanced caries. The first line of treatment is the removal of the source of inflammation or infection by local operative measures. Generally, the abscess can be eradicated through surgical drainage alone; however this is sometimes inadequate. Therefore, systemic antibiotic treatment may be required, but only if there is evidence of spreading infection. As the bacteria involved are known, antibiotic therapy selection can be specific, based on published susceptibilities. Penicillin in the form of amoxicillin is the most common antibiotic to use. However, 3% of the patient population is allergic to penicillin, so erythromycin is often used in
Antibiotic resistance in gonorrhea ability of the antibiotic to get into, or stay in the bacterial cell. High level resistance of "N. gonorrhoeae" to tetracyclines was first reported in 1986 with the discovering of the "tetM" determinant. The mechanism of resistance is still unknown. "N. gonorrhoeae" has also shown resistance to the aminoglycoside class of antibiotics. These antibiotics bind to the 16s rRNA of the 30S subunit of the bacterial ribosome, thereby stopping transcription of the bacterial genome. Resistance appears to be acquired through porin-related mechanisms, much like the cephalosporin resistance mechanism. This mechanism would result in the access of the antibiotic to the