Glipizide 10 milligrams. Glipizide sensitizes the beta cells of pancreatic islets of Langerhans insulin response, meaning that more insulin is released in response to glucose than would be without glipizide ingestion. Glipizide acts by partially blocking potassium channels among beta cells of pancreatic islets of Langerhans. By blocking potassium channels, the cell depolarizes, which results in the opening of voltage-gated calcium channels. The resulting calcium influx encourages insulin release from beta cells. Glipizide Glipizide is an oral rapid- and short-acting anti-diabetic medication from the sulfonylurea class. It is classified as a second-generation sulfonylurea, which means that it undergoes enterohepatic circulation. Second-generation
Chain Islets Chain Islets The Chain Islets and Great Chain Island (occasionally Great Chain Islet) are a group of at least 18 islets situated off the east coast of Oak Bay, British Columbia, Canada. They lie in Mayor Channel about halfway between Mary Tod Island (W) and Discovery Island (E). Most of the islets are very small, rocky, and are unnamed, except for Great Chain Island which is covered in grass and herbaceous cover with occasional shrub thickets. The islets are noted as an important gathering place for harbor seals in the summer and for many seabirds such as seagulls and cormorants.