Exercise physiology loss of integrity to the blood brain barrier. Hyperthermia also can lower cerebral blood flow, and raise brain temperature. Researchers once attributed fatigue to a build-up of lactic acid in muscles. However, this is no longer believed. Rather, lactate may stop muscle fatigue by keeping muscles fully responding to nerve signals. The available oxygen and energy supply, and disturbances of muscle ion homeostasis are the main factor determining exercise performance, at least during brief very intense exercise. Each muscle contraction involves an action potential that activates voltage sensors, and so releases Ca ions from the muscle fibre’s sarcoplasmic reticulum. The
Is the Is Are substance," following an incident in which their car was pulled over by the police, en route to the Basilica Music Festival. Smith stated that the incident greatly influenced the writing and recording of "Is the Is Are": "What happened to us was really shitty and traumatic, and it wasn’t something I did to get attention — it was the worst possible thing that could have happened at that moment. I knew it was going to take a really good album to save me. That’s what made it so hard to write, and why it took so long. If I didn’t