Rosalind Franklin and DNA best evidence for the structure of DNA. For the discovery of the correct chemical structure of DNA, the Nobel Prize in Physiology or Medicine 1962 was shared by her colleagues and close researchers James Watson, Francis Crick and Maurice Wilkins; she died four years earlier in 1958 making her inelligible for the award. Rosalind Franklin joined the King's College London in January 1951 to work on the crystallography of DNA. By the end of that year, she established two important facts: one is that phosphate groups, which are the molecular backbone for the nucleotide chains, lie on the outside (it
Molecular models of DNA is carried by spool-like proteins named histones, around which DNA winds. It is the further compaction of this DNA-protein complex which produces the well known mitotic eukaryotic chromosomes. In the late 1970s, alternate non-helical models of DNA structure were briefly considered as a potential solution to problems in DNA replication in plasmids and chromatin. However, the models were set aside in favor of the double-helical model due to subsequent experimental advances such as X-ray crystallography of DNA duplexes, and later the nucleosome core particle, and the discovery of topoisomerases. Such non-double-helical models are not currently accepted by the mainstream scientific