Pharmacodynamics of progesterone women, this effect being the result of suppression of the mid-cycle surge in gonadotropin secretion, is 300 mg/day. However, this figure is based on limited clinical data. Conversely, treatment with a high dosage of oral progesterone of 100 mg four times per day (or 400 mg/day total) in men for 10 days that resulted in approximately mid-luteal phase levels of progesterone (7.9–9.4 ng/mL; measured by ) did not cause any change in testosterone levels, suggesting that progesterone has little or no antigonadotropic effect in males at typical clinical dosages. In addition, a study found that administration of 1,000 mg/day oral
Menstrual disorder Menstrual disorder A menstrual disorder is an abnormal condition in a woman's menstrual cycle. Disorders of ovulation include oligoovulation and anovulation: "Polymenorrhea" is the medical term for cycles with intervals of 21 days or fewer. "Irregular menstruation" is where there is variation in menstrual cycle length of more than approximately eight days for a woman. The term "metrorrhagia" is often used for irregular menstruation that occurs between the expected menstrual periods. "Oligomenorrhea" is the medical term for infrequent, often light menstrual periods (intervals exceeding 35 days). "Amenorrhea" is the absence of a menstrual period in a woman of reproductive age.