Vitamin C megadosage 6-8 g/day. As of 2014, at least 16 studies had found that vitamin C supplements did not prevent the common cold and had minimal effect at best in shortening cold lengths. Vitamin C megadosage Vitamin C megadosage is a term describing the consumption or injection of vitamin C (ascorbic acid) in doses well beyond the current Recommended Dietary Allowance of 90 mg/day, and often well beyond the Tolerable upper intake level of 2,000 mg/day. There is no scientific evidence that megadosage helps to cure or prevent cancer, the common cold, or a variety of other medical conditions. Historic advocates of
Chemistry of ascorbic acid the presence of free metal ions can not only promote but also initiate free radical reactions, thus making it a potentially dangerous pro-oxidative compound in certain metabolic contexts. Ascorbic acid and its sodium, potassium, and calcium salts are commonly used as antioxidant food additives. These compounds are water-soluble and, thus, cannot protect fats from oxidation: For this purpose, the fat-soluble esters of ascorbic acid with long-chain fatty acids (ascorbyl palmitate or ascorbyl stearate) can be used as food antioxidants. It creates volatile compounds when mixed with glucose and amino acids in 90 °C. It is a cofactor in tyrosine oxidation.