Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Blood lead level glass of water containing lead and absorb 50% of it. An adult might only retain 10% of the lead in that water. And once the lead is in the child's body, it reaches the brain through the not fully developed blood brain barrier. The body removes lead from blood and stores it in bone, but in children it subsequently leaves the bone more readily compared to adults. "Lead that has accumulated in a woman's bones is removed from her bones and passes freely from mother to child; maternal and fetal blood lead levels are virtually identical. Once in the fetal