Willow active extract of the bark, called salicin, was isolated to its crystalline form in 1828 by Henri Leroux, a French pharmacist, and Raffaele Piria, an Italian chemist, who then succeeded in separating out the compound in its pure state. In 1897, Felix Hoffmann created a synthetically altered version of salicin (in his case derived from the "Spiraea" plant), which caused less digestive upset than pure salicylic acid. The new drug, formally acetylsalicylic acid, was named Aspirin by Hoffmann's employer Bayer AG. This gave rise to the hugely important class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). Some of humans'
Should Have Known Better Should Have Known Better "Should Have Known Better" is a song by American singer-songwriter and multi-instrumentalist Sufjan Stevens. It is the second track and second single from his seventh studio album, "Carrie & Lowell", and was released digitally on March 11, 2015 on Asthmatic Kitty. A promotional CD was later released on Asthmatic Kitty but was not available for sale. ""Should Have Known Better"" received very positive reviews from contemporary music critics. The song was chosen upon release as Pitchfork Media's "Best New Track". Jeremy Gordon stated that, " 'Should Have Known Better' takes us back to the beginning he