Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Tales from the Organ Trade one of the most impressive, and incisive, works of investigative journalism I’ve seen onscreen in a long time. It’s also a virtuosic feat of story-telling." and continues to say that Ric Esther Bienstock's film "is a nuanced, analytical portrait of the fierce ethical dilemmas on both sides of the issue, which Bienstock distills into cautious advocacy for a sensible solution." Tales from the Organ Trade Tales From the Organ Trade is a 2013 Canadian documentary film written and directed by Emmy Award-winning filmmaker Ric Esther Bienstock. It was produced by Ric Esther Bienstock, Felix Golubev and Simcha Jacobovici. The film