Protein signalling in heart development Protein signalling in heart development The heart is the first functional organ in a vertebrate embryo. There are 5 stages to heart development. Specification of cardiac precursor cells: The lateral plate mesoderm delaminates to form two layers: the dorsal somatic (parietal) mesoderm and the ventral splanchnic (visceral) mesoderm. The heart precursor cells come from the two regions of the splanchnic mesoderm called the cardiogenic mesoderm. These cells can differentiate into endocardium which lines the heart chamber and valves and the myocardium which forms the musculature of the ventricles and the atria. The heart cells are specified in anterior mesoderm by
How Many Licks? Neptunes has additional vocals from American artists Kelis, Lil' Cease, and Snoop Dogg. "How Many Licks?" was praised by music critics after its release and in retrospective reviews; the Neptunes remix also received positive reviews. However, African-American studies professor Mark Anthony Neal criticized the song's treatment of black female sexuality. Commentators compared its content to Trinidadian-American rapper Nicki Minaj's 2014 single, "Anaconda". "How Many Licks?" peaked at number 75 on the "Billboard" Hot 100 chart and charted in several other countries, but was not as commercially successful as Lil' Kim's previous releases. The song's music video was directed by Francis