Pituitary gland help control the following body processes: Some of the diseases involving the pituitary gland are: All of the functions of the pituitary gland can be adversely affected by an over- or under-production of associated hormones. The pituitary gland is important for mediating the stress response, via the hypothalamic–pituitary–adrenal axis (HPA axis) Critically, pituitary gland growth during adolescence can be altered by early life stress such as childhood maltreatment or maternal dysphoric behavior. It has been demonstrated that, after controlling for age, sex, and BMI, larger quantities of DHEA and DHEA-S tended to be linked to larger pituitary volume. Additionally, a
Pituitary adenylate cyclase-activating peptide Pituitary adenylate cyclase-activating peptide Pituitary adenylate cyclase-activating polypeptide also known as PACAP is a protein that in humans is encoded by the "ADCYAP1" gene. PACAP is similar to vasoactive intestinal peptide. One of its effects is to stimulate enterochromaffin-like cells. It binds to vasoactive intestinal peptide receptor and to the PACAP receptor. This gene encodes adenylate cyclase-activating polypeptide 1. Mediated by adenylate cyclase-activating polypeptide 1 receptors, this polypeptide stimulates adenylate cyclase and subsequently increases the cAMP level in target cells. Adenylate cyclase-activating polypeptide 1 not only is a hypophysiotropic hormone (i.e. a substance that induces activity in the hypophysis) but