Acute kidney injury are glomerulonephritis, acute tubular necrosis (ATN), and acute interstitial nephritis (AIN), respectively. Other causes of intrinsic AKI are rhabdomyolysis and tumor lysis syndrome. Certain medication classes such as calcineurin inhibitors (e.g., tacrolimus) can also directly damage the tubular cells of the kidney and result in a form of intrinsic AKI. "Postrenal" AKI refers to acute kidney injury caused by disease states downstream of the kidney and most often occurs as a consequence of urinary tract obstruction. This may be related to benign prostatic hyperplasia, kidney stones, obstructed urinary catheter, bladder stones, or cancer of the bladder, ureters, or prostate. Introduced
Bladder pipe into the bladder. While the first creation of a double reed pipe with a bladder controlling breath is unknown, it is believed to have originated in Europe before the 13th century. As an intermediate phase between the almost pan-European bagpipe and the Renaissance crumhorn, the Bladder pipe flourished from the 14th to 16th centuries. Examples have been found from Germany, Poland, England, France, Italy, Spain (called the odrecillo) and Estonia (called the rakkopilli). As it declined in popularity, it became associated with beggars and peasants. The early bladder pipe is in a family of the early medieval "chorus" instruments, a