Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
Acid King Acid King Acid King is a stoner metal band from San Francisco, California. It was formed in 1993 by frontwoman Lori S., drummer Joey Osbourne and bassist Peter Lucas. Acid King have since recorded four studio albums and two EPs with a series of bassists. The band's name was inspired by the crimes of Ricky Kasso, who murdered his friend Gary Lauwers in Northport, New York on June 19, 1984. Kasso was nicknamed "Acid King" by his peers due to his chronic hallucinogenic drug use. The band's debut EP features a photograph of Kasso on its cover. The band itself