Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Water organ Water organ The water organ or hydraulic organ () (early types are sometimes called hydraulos, hydraulus or hydraula) is a type of pipe organ blown by air, where the power source pushing the air is derived by water from a natural source (e.g. by a waterfall) or by a manual pump. Consequently, the water organ lacks a bellows, blower, or compressor. The hydraulic organ is often confused with the hydraulis. The hydraulis is the name of a Greek instrument created by Ctesibius of Alexandria. The hydraulis has a reservoir of air which is inserted into a cistern of water. The