Aestivation Aestivation Aestivation or æstivation (from , summer, but also spelled estivation in American English) is a state of animal dormancy, similar to hibernation, characterized by inactivity and a lowered metabolic rate, that is entered in response to high temperatures and arid conditions. It takes place during times of heat and dryness, the hot dry season, which are often the summer months. Invertebrate and vertebrate animals are known to enter this state to avoid damage from high temperatures and the risk of desiccation. Both terrestrial and aquatic animals undergo aestivation. The fossil record suggests that aestivation may have evolved several hundred
Cancer dormancy Cancer dormancy Dormancy is a stage in cancer progression where the cells cease dividing but survive in a quiescent state while waiting for appropriate environmental conditions to begin proliferation again. Quiescence is the state where cells are not dividing but at arrest in the cell cycle in G0-G1. Dormant cancer cells are thought to be present in early tumor progression, in micrometastases, or left behind in minimal residual disease (MRD) after what was thought to be a successful treatment of the primary tumor. Cancer dormancy is not yet fully understood, but some researchers have performed mathematical modeling to explain the