Pharmacokinetics of progesterone concentrations was around 4 hours and the elimination half-life was in the range of 30 to 40 hours. The venous blood levels observed were very low. Because progesterone is a lipophilic and hydrophobic compound, it is not absorbed efficiently by the skin. Moreover, because the body produces about 25 mg progesterone per day on average during the luteal phase, around 50% of the body would need to be used as a surface of absorption to deliver a similar quantity of progesterone. As such, the transdermal route cannot easily achieve adequate circulating progesterone levels, and this makes transdermal progesterone impractical for
Menstrual cycle of the menstrual cycle, regardless of fertility. Behavior towards potential mating partners changes during different phases of the menstrual cycle. Near ovulation, women may have increased physical attraction and interest in attending social gatherings with men. During the fertile phase of the cycle, women appear to prefer males who are more masculine. The intensity of mate guarding differs across the phases of the cycle, with increased mate guarding occurring when woman are fertile. During the fertile phase, many women experience more attraction, fantasies and sexual interest for extra pair men but not for the primary partner. They also engage in