Kidney stone disease to a combination of genetics and environmental factors. Risk factors include high urine calcium levels, obesity, certain foods, some medications, calcium supplements, hyperparathyroidism, gout and not drinking enough fluids. Stones form in the kidney when minerals in urine are at high concentration. The diagnosis is usually based on symptoms, urine testing, and medical imaging. Blood tests may also be useful. Stones are typically classified by their location: nephrolithiasis (in the kidney), ureterolithiasis (in the ureter), cystolithiasis (in the bladder), or by what they are made of (calcium oxalate, uric acid, struvite, cystine). In those who have had stones, prevention is
Bladder pipe into the bladder. While the first creation of a double reed pipe with a bladder controlling breath is unknown, it is believed to have originated in Europe before the 13th century. As an intermediate phase between the almost pan-European bagpipe and the Renaissance crumhorn, the Bladder pipe flourished from the 14th to 16th centuries. Examples have been found from Germany, Poland, England, France, Italy, Spain (called the odrecillo) and Estonia (called the rakkopilli). As it declined in popularity, it became associated with beggars and peasants. The early bladder pipe is in a family of the early medieval "chorus" instruments, a