Antibiotic resistance in gonorrhea Antibiotic resistance in gonorrhea The Gonorrhea bacterium Neisseria gonorrhoeae has developed antibiotic resistance to many antibiotics. The bacteria was first identified in 1879, although some Biblical scholars believe that references to the disease can be found as early as Parshat Metzora of the Old Testament. In the 1940s effective treatment with penicillin became available, but by the 1970s resistant strains predominated. Resistance to penicillin has developed through two mechanisms: chromasomally mediated resistance (CMRNG) and penicillinase-mediated resistance (PPNG). CMRNG involves step wise mutation of penA, which codes for the penicillin-binding protein (PBP-2); mtr, which encodes an efflux pump that removes penicillin
The Teacher Who Was Not To Be of Music. In his letter Thommessen chastised Paus for his tonal music. A long monologue on why Paus has misunderstood everything about music ends with the words "I do not want any more verbal contact with you." At the time the opera monologue premiered, the "Teacher" in the monologue remained anonymous. The monologue played an important role in an extensive debate on musical aesthetics in the music journal "Ballade" in 2015, during which the formerly anonymous "Teacher" was revealed by Paus to be Olav Anton Thommessen. The Teacher Who Was Not To Be The Teacher Who Was Not To Be