Apparent mineralocorticoid excess syndrome cases recorded worldwide. Liquorice consumption may also cause a temporary form of AME due to its ability to block 11β-hydroxysteroid dehydrogenase type 2, in turn causing increased levels of cortisol. Cessation of licorice consumption will reverse this form of AME. Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In
Water organ the musical cylinder and the movements attached. To start the organ, the tap above the entry pipe is turned on and, given a continuous flow of water, the organ plays until the tap is closed again. Many water organs had simple water-pressure regulating devices. At the Palazzo del Quirinale, the water flows from a hilltop spring (once abundant, now only sufficient to play the organ for about 30 minutes at a time), coursing through the palace itself into a stabilizing ‘room’ some 18 metres (59 feet) above the camera aeolis in the organ grotto. This drop provides sufficient wind to