Muscarinic antagonist brain, involving both increased levels of acetylcholine and degeneration of dopaminergic pathways (nigrostriatal pathway). Thus, in parkinsonism there is decreased level of dopaminergic activity. One method of balancing the neurotransmitters is through blocking central cholinergic activity using muscarinic receptor antagonists. Atropine acts on the M2 receptors of the heart and antagonizes the activity of acetylcholine. It causes tachycardia by blocking vagal effects on the sinoatrial node. Acetylcholine hyperpolarizes the sinoatrial node, which is overcome by MRA and thus increases the heart rate. If atropine is given by intramuscular or subcutaneous injection, it causes initial bradycardia. This is because by i.m/s.c
Longitude of the ascending node it is not possible to tell which node is ascending and which is descending. In this case the orbital parameter which is recorded is the longitude of the node, Ω, which is the longitude of whichever node has a longitude between 0 and 180 degrees. In astrodynamics, the longitude of the ascending node can be calculated from the specific relative angular momentum vector h as follows: Here, n=<"n", "n", "n"> is a vector pointing towards the ascending node. The reference plane is assumed to be the "xy"-plane, and the origin of longitude is taken to be the positive "x"-axis. k