Molecular models of DNA simulations that are very important to understand how DNA functions "in vivo". From the very early stages of structural studies of DNA by X-ray diffraction and biochemical means, molecular models such as the Watson-Crick nucleic acid double helix model were successfully employed to solve the 'puzzle' of DNA structure, and also find how the latter relates to its key functions in living cells. The first high quality X-ray diffraction patterns of A-DNA were reported by Rosalind Franklin and Raymond Gosling in 1953. Rosalind Franklin made the critical observation that DNA exists in two distinct forms, A and B, and produced
James Watson determined that their results were inconclusive and could not specifically identify the newly labeled molecules as DNA. Watson never developed a constructive interaction with Kalckar, but he did accompany Kalckar to a meeting in Italy, where Watson saw Maurice Wilkins talk about his X-ray diffraction data for DNA. Watson was now certain that DNA had a definite molecular structure that could be elucidated. In 1951, the chemist Linus Pauling in California published his model of the amino acid alpha helix, a result that grew out of Pauling's efforts in X-ray crystallography and molecular model building. After obtaining some results from