Heart rate persons with coronary artery disease. The heart rate is rhythmically generated by the sinoatrial node. It is also influenced by central factors through sympathetic and parasympathetic nerves. Nervous influence over the heartrate is centralized within the two paired cardiovascular centres of the medulla oblongata. The cardioaccelerator regions stimulate activity via sympathetic stimulation of the cardioaccelerator nerves, and the cardioinhibitory centers decrease heart activity via parasympathetic stimulation as one component of the vagus nerve. During rest, both centers provide slight stimulation to the heart, contributing to autonomic tone. This is a similar concept to tone in skeletal muscles. Normally, vagal stimulation
Pinky and the Brain to talk to humans, and anthropomorphism. "Project B.R.A.I.N." suggests that the gene splicing occurred on September 9, 1995, which is coincident to the first full episode of "Pinky and the Brain." The episode "Brainwashed" states that the gene splicing was done by Dr. Mordough, along with Snowball the hamster and Precious the cat, using the Acme Gene Splicer, Bagel Warmer, and Hot Dog Steamer. Although Pinky and the Brain plan to conquer the world, they do not show much animosity. In a christmas special, Pinky even wrote to Santa that Brain had the world's best interests at heart. The Brain