Tetrapod probably had a three-chambered heart, as do modern amphibians and reptiles, in which oxygenated blood from the lungs and de-oxygenated blood from the respiring tissues enters by separate atria, and is directed via a spiral valve to the appropriate vessel — aorta for oxygenated blood and pulmonary vein for deoxygenated blood. The spiral valve is essential to keeping the mixing of the two types of blood to a minimum, enabling the animal to have higher metabolic rates, and be more active than otherwise. The difference in density between air and water causes smells (certain chemical compounds detectable by chemoreceptors) to
Renal vein directly into the IVC. Often, each renal vein will have a branch that receives blood from the ureter. It is usually singular to each kidney, except in the condition "multiple renal veins". In some people the left renal vein passes behind the abdominal aorta instead of in front of it, this is termed a retroaortic left renal vein, which is also known as "The Vein of Schnitker." If there is both a vein passing in front of and one behind the aorta this is called a circumaortic renal vein. Diseases associated with the renal vein include renal vein thrombosis (RVT)