Endocrine system of loss of reserve, hyposecretion, agenesis, atrophy, or active destruction. Hyperfunction can occur as a result of hypersecretion, loss of suppression, hyperplastic or neoplastic change, or hyperstimulation. Endocrinopathies are classified as primary, secondary, or tertiary. Primary endocrine disease inhibits the action of downstream glands. Secondary endocrine disease is indicative of a problem with the pituitary gland. Tertiary endocrine disease is associated with dysfunction of the hypothalamus and its releasing hormones. As the thyroid, and hormones have been implicated in signaling distant tissues to proliferate, for example, the estrogen receptor has been shown to be involved in certain breast cancers. Endocrine,
Toxic Substances Control Act of 1976 later explained during a 1975 Congressional Testimony, "While some authority exists to control the production of certain categories of toxic substances, such as pesticides, drugs, and food additives, most existing Federal authorities are designed to prevent harmful exposure only after the substances have been introduced into production." In Order to adequately regulate what chemicals should enter the environment, CEQ recommended that the government create a more comprehensive chemical policy to identify and control the chemicals that are manufactured, produced, and used in the U.S economy. Specifically, CEQ recommended that TSCA strengthen government oversight by requiring the following measures: First, manufacturers