Pacemaker current on hyperpolarization, and very slow kinetics. The funny current is highly expressed in spontaneously active cardiac regions, such as the sinoatrial node (SAN, the natural pacemaker region), the atrioventricular node (AVN) and the Purkinje fibres of conduction tissue. The funny current is a mixed sodium–potassium current that activates upon hyperpolarization at voltages in the diastolic range (normally from −60/−70 mV to −40 mV). When, at the end of a sinoatrial action potential, the membrane repolarizes below the I threshold (about −40/−50 mV), the funny current is activated and supplies inward current, which is responsible for starting the diastolic depolarization phase
Sentinel node list, can be simplified remarkably using a sentinel node to demarcate the beginning and end of the list. Following is a Python implementation of a circular doubly-linked list: Notice how the codice_13 method takes the node that will be displaced by the new node in the parameter codice_14. For appending to the left, this is the head of a non-empty list, while for appending to right, it is the tail. But because of how the linkage is setup to refer back to the sentinel, the code just works for empty lists as well, where codice_14 will be the sentinel node.