John Jacob Abel the position of chair of the department until he retired at the age of 75 in 1932. Ever since his early years in Europe, Abel showed great interest in isolating pure form of internal gland hormones. The first work that led to his international reputation as a pharmacologist and biochemist was the isolation of epinephrine from adrenal medulla. However, he was only able to isolate a monobenzoyl derivative of epinephrine. While he was improving his processes on decomposing the benzoyl derivative to obtain salts of epinephrine using saponification, a Japanese chemist J. Takamine, who had visited his lab, was able
Local hormone regulate activity of G-protein coupled receptors. Most often found in the pancreas and the intestines. Secretin was discovered in 1902 by E. H. Starling. It was later linked to chemical regulation and was the first substance to be deemed a hormone. 3. Mark H. Whitnall, William G. Haynes, David J. Webb (1997). Principles of Medical Biology. 4. Salmon, John A; Higgs, Gerald A (1987). "Prostaglandins and leukotrienes as inflammatory mediators". "British Medical Bulletin". 43 (2): 285–96. PMID 2825898 5. SF Gilbert. (2000). Developmental Biology 6th Edition. 6. Jan M. Keppel Hesselink.(2016). "Autacoids: A New Fundament for Pain Medicine of the