Snowflake in the same micro-environment does not guarantee that each arm grow the same; indeed, for some crystal forms it does not because the underlying crystal growth mechanism also affects how fast each surface region of a crystal grows. Empirical studies suggest less than 0.1% of snowflakes exhibit the ideal six-fold symmetric shape. Very occasionally twelve branched snowflakes are observed; they maintain the six-fold symmetry. Snowflakes form in a wide variety of intricate shapes, leading to the notion that "no two are alike". Although nearly-identical snowflakes have been made in laboratory, they are very unlikely to be found in nature. Initial
Remitting seronegative symmetrical synovitis with pitting edema years in most studies. It occurs more often in men than in women with a 2:1 ratio. It is unknown how common this condition is. Individuals affected by RS3PE typically have repeated episodes of inflammation of the lining of their synovial joints and swelling of the end portion of the limbs. The arms and hands are more commonly affected than the legs and feet. Both sides are usually involved though RS3PE can affect only one side in certain cases. RS3PE is a constellation of symptoms that can be caused by many other conditions. Since there is no definitive diagnostic test,