Endocrine gland been implicated in proliferation, one of the required steps of oncogenesis. Other common diseases that result from endocrine dysfunction include Addison’s disease, Cushing’s disease and Grave’s disease. Cushing's disease and Addison's disease are pathologies involving the dysfunction of the adrenal gland. Dysfunction in the adrenal gland could be due to primary or secondary factors and can result in hypercortisolism or hypocortisolism . Cushing’s disease is characterized by the hypersecretion of the adrenocorticotropic hormone (ACTH) due to a pituitary adenoma that ultimately causes endogenous hypercortisolism by stimulating the adrenal glands. Some clinical signs of Cushing’s disease include obesity, moon face, and
Obesity and the environment trigger." The theory of environmental obesogens proposes a different causal facet to obesity – that lifetime exposure to xenobiotic chemicals may change the body's metabolic system. Chemical obesogens are molecules that do not properly regulate lipid metabolism in the body and could therefore promote obesity. Data is scarce, but some in-vitro studies have found this model could be an accurate predictor of future obesity. A study suggested that smoking before and during pregnancy, for example, increases the risk of obesity twofold in children of school age. Many chemicals that are known or suspected to be obesogens are endocrine disruptors. These