Allergic inflammation immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema. The late phase of a Type 1 reaction (which develops 8–12
Theology of the Body In addition to the importance of power over nature, Descartes (like Bacon) insisted upon dismissing final cause, stating that “the entire class of causes which people customarily derive from a thing’s ‘end,’ I judge to be utterly useless”. Descartes’ practical philosophy also proposed a dualism between the mind and the physical body, based on the belief that they are two distinct substances. The body is matter that is spatially extended, whereas the mind is the substance that thinks and contains the rational soul. Pope John Paul II responded to this dualism in his "Letter to Families" in 1994: “It is