Giraffe have unusually high heart rates for their size, at 150 beats per minute. When the animal lowers its head the blood rushes down fairly unopposed and a rete mirabile in the upper neck, with its large cross sectional area, prevents excess blood flow to the brain. When it raises again, the blood vessels constrict and direct blood into the brain so the animal does not faint. The jugular veins contain several (most commonly seven) valves to prevent blood flowing back into the head from the inferior vena cava and right atrium while the head is lowered. Conversely, the blood vessels
Drug delivery to the brain and be effective to enter the brain. This must be done in a very controlled environment because of the risk associated with these drugs. Firstly, the brain can be flooded with molecules that are floating through the blood stream that are usually blocked by the barrier. Secondly, when the tight junctions loosen, the homeostasis of the brain can also be thrown off which can result in seizures and the compromised function of the brain. The most promising drug delivery system is using nanoparticle delivery systems, these are systems where the drug is bound to a nanoparticle capable of traversing the