Valerian (herb) some affinity for the GABA receptor, a class of receptors on which benzodiazepines are known to act. Valeric acid, which is responsible for the typical odor of mostly older valerian roots, does not have any sedative properties. Valeric acid is related to valproic acid, a widely prescribed anticonvulsant; valproic acid is a derivative of valeric acid. Valerian also contains isovaltrate, which has been shown to be an inverse agonist for adenosine A receptor sites. This action likely does not contribute to the herb's possible sedative effects, which would be expected from an agonist, rather than an inverse agonist, at this
Valerian Madatov Lieutenant General. He concluded his career fighting the Turks once again on the Danube during the Russo-Turkish War, 1828-1829. On September 4, 1829, two days after the signing of a peace treaty that ended the war, Madatov died from a pulmonary disease, which was sharply aggravated as a result of the burdens of marching during the war. His remains are interred at the Alexander Nevsky Lavra in Saint Petersburg. Valerian Madatov Prince Valerian Grigoryevich Madatov (, , Rostom Madatyan) (1782 – September 4, 1829) was a Russian prince and a lieutenant-general of the Russian Empire. Madatov was born Rostom Madatyan