Exercise physiology loss of integrity to the blood brain barrier. Hyperthermia also can lower cerebral blood flow, and raise brain temperature. Researchers once attributed fatigue to a build-up of lactic acid in muscles. However, this is no longer believed. Rather, lactate may stop muscle fatigue by keeping muscles fully responding to nerve signals. The available oxygen and energy supply, and disturbances of muscle ion homeostasis are the main factor determining exercise performance, at least during brief very intense exercise. Each muscle contraction involves an action potential that activates voltage sensors, and so releases Ca ions from the muscle fibre’s sarcoplasmic reticulum. The
External intercostal muscles occurs. External intercostal muscles The external intercostal muscles, or external intercostals (Intercostales externi) are eleven in number on both sides. The muscles extend from the tubercles of the ribs behind, to the cartilages of the ribs in front, where they end in thin membranes, the external intercostal membranes, which are continued forward to the sternum. These muscles work in unison when inhalation occurs. The internal intercostal muscles relax while the external muscles contract causing the expansion of the chest cavity and an influx of air into the lungs. Each arises from the lower border of a rib, and is inserted