Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
Acid Tests Acid Tests The Acid Tests were a series of parties held by author Ken Kesey primarily in the San Francisco Bay Area during the mid-1960s, centered entirely on the use of, and advocacy of, the psychedelic drug LSD, also known as "acid". LSD-25 was not made illegal in California until October 6, 1966. The name "Acid Test" was coined by Kesey, after the term "acid test" used by gold miners in the 1850s. He began throwing parties at his farm at La Honda, California. The Merry Pranksters were central to organizing the Acid Tests, including Pranksters such as Lee Quarnstrom