Versican other inflammatory cells) can migrate more easily through extracellular matrix that has a higher versican content. Deposits of versican are not present in normal skin but are found in the reticular dermis during keloid scarring, a condition where scar formation becomes uncontrolled and overgrowth of skin tissue occurs at the site of the wound. Versican has been shown to interact with hyaluronan and a link protein (hyaluronan and proteoglycan link protein 1; HAPLN1). Versican Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the "VCAN" gene. Versican is a
Scar (The Lion King) artist Jorgen Klubien. According to the directors, "[a] patronizing quality" was vital to Scar's role in the film. Minkoff told the "Los Angeles Times", "When Scar puts the guilt trip on Simba, that's an intense idea ... probably something that is "not" typical of the other Disney pictures, in terms of what the villain does." Additionally, Scar serves as a departure from previous Disney villains because they "came off at least as buffoonish as they were sinister". Because Scar is the film's main antagonist, supervising animator Andreas Deja believed that "villains work really well when they're subtle", explaining, "to see