Natural product to modern discovery of their active ingredients and eventually to the development of new drugs. A large number of currently prescribed drugs have been either directly derived from or inspired by natural products. A few representative examples are listed below. Some of the oldest natural product based drugs are analgesics. The bark of the willow tree has been known from antiquity to have pain relieving properties. This is due to presence of the natural product salicin which in turn may be hydrolyzed into salicylic acid. A synthetic derivative acetylsalicylic acid better known as aspirin is a widely used pain reliever.
U Should've Known Better producers, which included Dallas Austin, production team Soulshock & Karlin, Bryan Michael Cox, and Rodney Jerkins and his Darkchild crew. Though she "had never thought about writing much" by then, her producers encouraged the singer to intensify her work on the "All Eyez on Me" album and to write and contribute own lyrics and ideas to the songs, one of which was the ballad "U Should've Known Better." Monica penned the song along with Harold Lilly and longtime contributor Jermaine Dupri, while production on the track was helmed by Dupri and Bryan Michael Cox. "U Should've Known Better" was mixed