Effect of spaceflight on the human body of muscle fibre prominent in muscles also change. Slow twitch endurance fibres used to maintain posture are replaced by fast twitch rapidly contracting fibres that are insufficient for any heavy labour. Advances in research on exercise, hormone supplements and medication may help maintain muscle and body mass. Bone metabolism also changes. Normally, bone is laid down in the direction of mechanical stress. However, in a microgravity environment there is very little mechanical stress. This results in a loss of bone tissue approximately 1.5% per month especially from the lower vertebrae, hip and femur. Due to microgravity and the decreased load
The Biggest Douche in the Universe are friends of Trey Parker and Matt Stone and have stated that this is their favorite episode. According to the commentary for this episode, Trey Parker described the creation of the episode as being centered on John Edward who the entire crew of South Park Studios agreed was "the biggest douche in the universe." That was until Matt Stone asked the question "Well, what about Rob Schneider?" leading to the fictional trailers. Parker and Stone credit James Randi with Stan's explanation of cold reading. The Biggest Douche in the Universe "The Biggest Douche in the Universe" is the 15th episode