Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
Patellar tendon rupture weakness after the injury and repair. If the tendon rupture is a partial tear (without the two parts of the tendon being separated) then non-surgical methods of treatment may suffice. The future of non-surgical care for partial patella tendon ruptures is likely bioengineering. Ligament reconstruction is possible using mesenchymal stem cells and a silk scaffold. These same stem cells have been shown to be capable of seeding repair of damaged animal tendons. In 2010, a clinical study proved that mechanical loading of the tendon callus during the remodelling phase leads to healing by regeneration. Patellar tendon rupture Patellar tendon rupture