Human tooth development the low levels of fluoride incorporation and very mild fluorosis makes the tooth more resistant to demineralization and subsequent decay. Deficiencies of nutrients can have a wide range of effects on tooth development. In situations where calcium, phosphorus, and vitamin D are deficient, the hard structures of a tooth may be less mineralized. A lack of vitamin A can cause a reduction in the amount of enamel formation. Fluoride ingestion has been noted to delay eruption of teeth for as much as a year or more from the accepted eruption dates since the initial 1940s fluoridation trials. Researchers theorize that
Layer by Layer there are many variant techniques for the final layer, depending on whether the corner or edge pieces are solved first. The CFOP speedcubing technique, developed by Jessica Fridrich and others in the 1980s, similarly divides the puzzle into layers to be solved. However the method uses far more algorithms and shortcuts than the beginners' methods. Layer by Layer The Layer by Layer method is a method of solving the 3x3x3 Rubik's Cube. Many beginners' methods use this approach, but it also forms the basis of the CFOP speedcubing technique. The Layer by Layer Method was pioneered by David Singmaster in