Oxygen–hemoglobin dissociation curve the fluid that surrounds it. Hemoglobin (Hb) is the primary vehicle for transporting oxygen in the blood. Oxygen is also carried dissolved in the blood's plasma, but to a much lesser degree. Hemoglobin is contained in red blood cells. Under certain conditions, oxygen bound to the hemoglobin is released into the blood's plasma and absorbed into the tissues. Each hemoglobin molecule has the capacity to carry four oxygen molecules. These molecules of oxygen bind to the iron of the Heme group. The binding of the first oxygen molecule induces a conformational change of hemoglobin that increases the affinity for the
The Hallmarks of Cancer apoptosis, karyotypic disarray, and the occasional (10) emergence of an immortalized cell that can double without limit. Most tumor cells are immortalized. The counting device for cell doublings is the telomere, which decreases in size (loses nucleotides at the ends of chromosomes) during each cell cycle. About 85% of cancers upregulate telomerase to extend their telomeres and the remaining 15% use a method called the Alternative Lengthening of Telomeres. Normal tissues of the body have blood vessels running through them that deliver oxygen from the lungs. Cells must be close to the blood vessels to get enough oxygen for them