Red blood cell macrophages and subsequent phagocytosis in the mononuclear phagocyte system (spleen, liver and lymph nodes), thus removing old and defective cells and continually purging the blood. This process is termed eryptosis, red blood cell programmed cell death. This process normally occurs at the same rate of production by erythropoiesis, balancing the total circulating red blood cell count. Eryptosis is increased in a wide variety of diseases including sepsis, haemolytic uremic syndrome, malaria, sickle cell anemia, beta-thalassemia, glucose-6-phosphate dehydrogenase deficiency, phosphate depletion, iron deficiency and Wilson's disease. Eryptosis can be elicited by osmotic shock, oxidative stress, energy depletion as well as a
Blood Red Horse Blood Red Horse Blood Red Horse is a 2004 young adult historical novel by author K M Grant. The book was published in 2004 by Puffin Books and in the US in 2005 by Walker Children's. "Blood Red Horse" is the first novel in the De Granville Trilogy and was followed by the books "Green Jasper" and "Blaze of Silver". In 2006 the audiobook version of "Blood Red Horse" won an AudioFile Earphones Award and in 2007 was one of YALSA's recommended audiobooks for 2007. "Blood Red Horse" follows Will and Ellie, two young teens growing up during the time