Gonadal dysgenesis If a single or combination of these genes are mutated or deleted, downstream signalling is disrupted, leading to malformation of male external genitalia. SRY acts on gene SOX9 which drives Sertoli cell formation and testis differentiation. An absence in SRY causes SOX9 to not be expressed at the appropriate time or concentration, leading to a deficiency in testosterone and Anti-Müllerian hormone production. Inadequate levels of testosterone and Anti-Müllerian hormone disrupts the development of Wolffian ducts and internal genitalia that are key to male reproductive tract development. The lack of the male associated steroid hormones drives Müllerian duct development and perusal
Causes of sexual violence that a correct knowledge of the causes of rape is necessary in order to develop effective preventive measures. There is extensive research on sexual coercion. Causes of sexual violence Causes of sexual violence are debated and explanations of the cause include military conquest, socioeconomics, anger, power, sadism, sexual pleasure, psychopathy, ethical standards, laws, attitudes toward the victims and evolutionary pressures. Clinical psychologist Nicholas Groth has described several different types of rape. A detailed conceptual analysis shows that objectification might underlie denial of agency and personhood that leads to rape. The goal of this rapist is to humiliate, debase and hurt