Menstrual cycle occur as a result of adopting a restricted diet, as well as engaging in a high amount of exercise. Finally, the cycle is affected more by a vegetarian diet compared to a non-vegetarian diet. Studies investigating effects of the menstrual cycle on alcohol consumption have found mixed evidence. However, some evidence suggests that individuals consume more alcohol during the luteal stage, especially if these individuals are heavy drinkers or have a family history of alcohol abuse. The level of substance abuse increases with PMS, mostly with addictive substances such as nicotine, tobacco and cocaine. One theory behind this suggests this
Selective progesterone receptor modulator or psychosis. Beside that SPRMs are under development for various gynecological applications, including estrogen-free contraception, uterine leiomyoma and endometriosis. Selective progesterone receptor modulator A selective progesterone receptor modulator (SPRM) is an agent that acts on the progesterone receptor (PR), the biological target of progestogens like progesterone. A characteristic that distinguishes such substances from full receptor agonists (e.g., progesterone, progestins) and full antagonists (e.g., aglepristone) is that their action differs in different tissues, i.e. agonist in some tissues while antagonist in others. This mixed profile of action leads to stimulation or inhibition in tissue-specific manner, which further raises the possibility of