Psychrophrynella wettsteini Psychrophrynella wettsteini Psychrophrynella wettsteini is a species of frog in the family Craugastoridae. It is endemic to Bolivia and only known from the region of Unduavi in the Unduavi Valley, Sud Yungas Province, La Paz Department. Common name Wettstein's Andes frog has been coined for it. It is named for Otto von Wettstein, Austrian zoologist. "Psychrophrynella wettsteini" is a comparatively large species (maximum snout–vent length ) and has a robust body and long limbs. The snout is rounded. The tympanic membrane is absent, whereas the tympanic annulus is visible through the skin. Tips of the digits are only slightly swollen.
Membrane curvature several amphipathic alpha helices that allows it to partition between the hydrophobic core of the membrane and surrounding aqueous, hydrophilic environment. Another interesting characteristic of epsin and other proteins that bind to membranes is the fact that it shows high binding affinity for a fairly common membrane lipid, phosphatidylinositol 4,5-bisphosphate (PI-4,5-P2). Unlike other proteins that simply bend the membrane through sheer rigidity, epsin is a globular soluble protein and thus not rigid. The insertion of its helices into the membrane force the neighboring lipids of the leaflet that has been bound to expand laterally. This displacement of lipids on only