Gene therapy of the human retina levels of light. What follows often is the death of cone cells, responsible for color vision and acuity, at light levels present during the day. Loss of cones leads to full blindness as early as five years old, but may not onset until many years later. There have been multiple hypotheses about how the lack of rod cells can lead to the death of cone cells. Pinpointing a mechanism for RP is difficult because there are more than 39 genetic loci and genes correlated with this disease. In an effort to find the cause of RP, there have been different
Retinal precursor cells Wnt11 is localized in the center of the developing retina and is suggested to play a role in precursor cell differentiation. This expression coincides with the fact that committed cells are located in the center of the developing retina while undifferentiated cells are concentrated in the periphery Fz5 expression is implicated in differentiation of retinal precursor cells to a neural fate. Retinal precursor cells Retinal precursor cells are biological cells that differentiate into the various cell types of the retina during development. In the vertebrate, these retinal cells differentiate into seven cell types, including retinal ganglion cells, amacrine cells, bipolar