History of aspirin mid-eighteenth century. By the nineteenth century pharmacists were experimenting with and prescribing a variety of chemicals related to salicylic acid, the active component of willow extract. In 1853, chemist Charles Frédéric Gerhardt treated acetyl chloride with sodium salicylate to produce acetylsalicylic acid for the first time; in the second half of the nineteenth century, other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis. In 1897, scientists at the drug and dye firm Bayer began investigating acetylsalicylic acid as a less-irritating replacement for standard common salicylate medicines, and identified a new way to synthesize it.
Moronic acid resistant to (bevirimat). This derivative has become a new lead for clinical trials and is also active against herpes simplex virus 1. Moronic acid Moronic acid (3-oxoolean-18-en-28-oic acid) is a natural triterpene. Moronic acid can be extracted from "Rhus javanica", a sumac plant traditionally believed to hold medicinal applications. The molecule has also been extracted from Mistletoe ("Phoradendron reichenbachianum"). Bevirimat, a derivative of the related triterpenoid betulinic acid, is under development as an anti-HIV drug; however, moronic acid has shown better antiviral profiles "in vitro" than bevirimat. A particular moronic acid derivative showed potent anti-HIV activity with EC values of