Antibiotic sensitivity culture the bacteria. This can help in the diagnosis. Once a culture is established, there are two possible ways to get an antibiogram: Once the MIC is calculated, it can be compared to known values for a given bacterium and antibiotic: e.g. a MIC > 0,06 µg/ml may be interpreted as a penicillin-resistant "Streptococcus pneumoniae". Such information may be useful to the clinician, who can change the empirical treatment, to a more custom-tailored treatment that is directed only at the causative bacterium. Often clinical specimens are sent to the clinical laboratory for culture and sensitivity (C&S), which is culture and
A22 (antibiotic) A22 binds directly to the actin homolog MreB in its nucleotide-binding pocket, blocking simultaneous ATP binding. As a consequence, A22 inhibits MreB polymerization and thus disrupts the cytoskeleton of bacteria, causing defects of morphology and chromosome segregation. A22 (antibiotic) A22, also known as "S"-(3,4-dichlorbenzyl)isothiourea, is a chemical compound with antibiotic activity. It is colorless, hygroscopic, and light-sensitive. A22 acts as a reversible inhibitor of the bacterial cell wall protein MreB, causing bacterial rod-shaped cells to form coccoid cells. The antibiotic activity of A22 has been studied primarily in "Pseudomonas aeruginosa." However, A22 does not seem to be useful as an