Pacemaker current on hyperpolarization, and very slow kinetics. The funny current is highly expressed in spontaneously active cardiac regions, such as the sinoatrial node (SAN, the natural pacemaker region), the atrioventricular node (AVN) and the Purkinje fibres of conduction tissue. The funny current is a mixed sodium–potassium current that activates upon hyperpolarization at voltages in the diastolic range (normally from −60/−70 mV to −40 mV). When, at the end of a sinoatrial action potential, the membrane repolarizes below the I threshold (about −40/−50 mV), the funny current is activated and supplies inward current, which is responsible for starting the diastolic depolarization phase
Node (Well of Echoes) or node-drainers that drain the node of the field and render anything that draws power from it useless. Mancers who cannot draw from a distat node's field must rely on charged crystals, while clankers, constructs and any other devices of the Art will not work. There are also rare places called anti-nodes, where the Art does not work or is at least greatly reduced. Node (Well of Echoes) Nodes are fictional, naturally occurring phenomena in Ian Irvine’s "The Three Worlds Cycle" of novels. They often occur in places where there is a significant landmark, such as on a hill or