Pleiotropy to have protein. Sickle cell anemia is a genetic disease that causes deformed red blood cells with a rigid, crescent shape instead of the normal flexible, round shape. It is caused by a change in one nucleotide, a point mutation in the HBB gene. The HBB gene encodes information to make the beta-globin subunit of hemoglobin, which is the protein red blood cells use to carry oxygen throughout the body. Sickle cell anemia occurs when the HBB gene mutation causes both beta-globin subunits of hemoglobin to change into hemoglobinS (HbS). Sickle cell anemia is a pleiotropic disease because the expression
Blood the presence of potential molecular fibers in the form of fibrinogen. Blood performs many important functions within the body, including: Blood accounts for 7% of the human body weight, with an average density around 1060 kg/m, very close to pure water's density of 1000 kg/m. The average adult has a blood volume of roughly , which is composed of plasma and several kinds of cells. These blood cells (which are also called corpuscles or "formed elements") consist of erythrocytes (red blood cells, RBCs), leukocytes (white blood cells), and thrombocytes (platelets). By volume, the red blood cells constitute about 45% of