Cardiac action potential that originates from the sinoatrial node is propagated via the His-Purkinje network, the fastest conduction pathway within the heart. The electrical signal travels from the sinoatrial node (SAN), which stimulates the atria to contract, to the atrioventricular node (AVN) which slows down conduction of the action potential, from the atria to the ventricles. This delay allows the ventricles to fully fill with blood before contraction. The signal then passes down through a bundle of fibres called the bundle of His, located between the ventricles, and then to the purkinje fibers at the bottom (apex) of the heart, causing ventricular contraction.
Sentinel lymph node of false-negative with melanocytic staining. There are various advantages to the sentinel node procedure. First and foremost, it decreases lymph node dissections where unnecessary, thereby reducing the risk of lymphedema, a common complication of this procedure. Increased attention on the node(s) identified to most likely contain metastasis is also more likely to detect micro-metastasis and result in staging and treatment changes. Its main uses are in breast cancer and malignant melanoma surgery, although it has been used in other tumor types (colon cancer) with a degree of success. Other cancers which have been investigated with this technique are penile cancer,