Karel Frederik Wenckebach "second degree AV block" and later named the "Wenckebach phenomenon" and reclassified as Mobitz type I block in Mobitz's 1924 paper. A similar phenomenon can also occur in the Sinoatrial node where it gives rise to Type I second degree SA block, and this is also known as a Wenckebach block; the two have distinct features on an ECG however. Wenckebach is credited for describing the median bundle of the heart's conductive system that connects the sinoatrial node to the atrioventricular node. This bundle was named Wenckebach's bundle, and is also known as the middle internodal tract. Wenckebach's bundle is
Sinoatrial node (in particular T1-T4). These nerves release a neurotransmitter called noradrenaline (NA). This binds to a receptor on the SA node membrane, called a beta-1adrenoceptor. Binding of NA to this receptor activates a G-protein (in particular a G-Protein, S for stimulatory) which initiates a series of reactions (known as the cAMP pathway) that results in the production of a molecule called cyclic adenosinemonophosphate (cAMP). This cAMP binds to the HCN channel (see above). Binding of cAMP to the HCN, increases the flow of Na and K into the cell, speeding up the pacemaker potential, so producing action potentials at a quicker