Nav1.5 kb. The gene consists of 28 exons, of which exon 1 and in part exon 2 form the 5’ untranslated region (5’UTR) and exon 28 the 3’ untranslated region (3’UTR) of the RNA. SCN5A is part of a family of 10 genes that encode different types of sodium channels, i.e. brain-type (Na1.1, Na1.2, Na1.3, Na1.6), neuronal channels (Na1.7, Na1.8 and Na1.9), skeletal muscle channels (Na1.4) and the cardiac sodium channel Na1.5. SCN5A is mainly expressed in the heart, where expression is abundant in working myocardium and conduction tissue. In contrast, expression is low in the sinoatrial node and atrioventricular node.
Node (circuits) Dots used to mark nodes on a circuit diagram are sometimes referred to as "meatballs". Node (circuits) In electrical engineering, a node is any point on a circuit where the terminals of two or more circuit elements meet. In circuit diagrams, connections are ideal wires with zero resistance, so a node may consist of the entire section of wire between elements, not just a single point. According to Ohm's law, "V = IR", the voltage across any two points of a node with negligible resistance is showing that the voltage at every point of a node is the same. However,