Antibiotic resistance in gonorrhea mechanism for beta-lactam resistance. There have been over 200 beta-lactamases described and some of them are antibiotic specific. TEM-1 is a penicillinase specific for penicillins. This enzyme will bind to the beta-lactam ring which is a structural characteristic for beta-lactams and hydrolyze the ring. This renders the antibiotic inactive. The spread of the penicillinase resistance was much faster compared to the chromosomal-mediated resistance mechanisms. The plasmids containing TEM-1 could be passed from bacterium to bacterium via conjugation Quinolones are a class of synthetic antibiotics that inhibit DNA replication, recombination, and repair by interacting with the bacterial DNA gyrase and/or topoisomerase
Antibiotic sensitivity antibiotic sensitivity testing offered as one combined service. This is because the clinician needs to know which organism is causing the infection, and which drugs will specifically work against this strain. Jump up ^ http://www.uphs.upenn.edu/bugdrug/antibiotic_manual/bk.html Jump up ^ http://www.slideshare.net/doctorrao/antibiotic-sensitivity-testing-presentation Jump up ^ http://cid.oxfordjournals.org/content/49/11/1749.full Jump up ^ http://www.microrao.com/micronotes/antibiotic.pdf Antibiotic sensitivity Antibiotic sensitivity or antibiotic susceptibility is the susceptibility of bacteria to antibiotics. Because susceptibility can vary even within a species (with some strains being more resistant than others), antibiotic susceptibility testing (AST) is usually carried out to determine which antibiotic will be most successful in treating a bacterial infection in vivo.