Protein signalling in heart development Protein signalling in heart development The heart is the first functional organ in a vertebrate embryo. There are 5 stages to heart development. Specification of cardiac precursor cells: The lateral plate mesoderm delaminates to form two layers: the dorsal somatic (parietal) mesoderm and the ventral splanchnic (visceral) mesoderm. The heart precursor cells come from the two regions of the splanchnic mesoderm called the cardiogenic mesoderm. These cells can differentiate into endocardium which lines the heart chamber and valves and the myocardium which forms the musculature of the ventricles and the atria. The heart cells are specified in anterior mesoderm by
How Many Licks? (Oh My)", Neal wrote that Tweet's focus on masturbation was a better expression of black female sexuality. The remix of "How Many Licks?" was also praised in retrospective reviews. In a 2015 article, Michael Arceneaux of VH1 called it "an under-appreciated gem" and suggested that Lil' Kim record another collaboration with Neptunes member Pharrell Williams in the future. According to Arceneaux, the remix is treated with "great reverence" by fans. Mark Anthony Neal was more critical of the remix due to Fabolous' lyrics ("Oops, there goes my kids on your face"), saying that the addition changed the song's message from