Apparent mineralocorticoid excess syndrome cases recorded worldwide. Liquorice consumption may also cause a temporary form of AME due to its ability to block 11β-hydroxysteroid dehydrogenase type 2, in turn causing increased levels of cortisol. Cessation of licorice consumption will reverse this form of AME. Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In
Water organ England; Cornelius Drebbel built one for King James I (Harstoffer, 1651), and Salomon de Caus built several at Richmond while in the service of Prince Henry. There was one in Bagnigge Vale, London, the summer home of Nell Gwynn (1650–87), and Henry Winstanley (1644–1703), the designer of the Eddystone Lighthouse, is thought to have built one at his home in Saffron Walden, Essex. After the marriage of Princess Elizabeth to the Elector Palatine Prince Friedrich V, de Caus laid out for them the gardens at Heidelberg Castle which became famous for their beautiful and intricate waterworks. A water organ survives