Pacemaker current on hyperpolarization, and very slow kinetics. The funny current is highly expressed in spontaneously active cardiac regions, such as the sinoatrial node (SAN, the natural pacemaker region), the atrioventricular node (AVN) and the Purkinje fibres of conduction tissue. The funny current is a mixed sodium–potassium current that activates upon hyperpolarization at voltages in the diastolic range (normally from −60/−70 mV to −40 mV). When, at the end of a sinoatrial action potential, the membrane repolarizes below the I threshold (about −40/−50 mV), the funny current is activated and supplies inward current, which is responsible for starting the diastolic depolarization phase
Lunar node Lunar node A lunar node is either of the two orbital nodes of the Moon, that is, the two points at which the orbit of the Moon intersects the ecliptic. The "ascending" (or "north") node is where the Moon moves into the northern ecliptic hemisphere, while the "descending" (or "south") node is where the Moon enters the southern ecliptic hemisphere. A lunar eclipse can occur only when the full Moon is near (within 11° 38' ecliptic longitude) either lunar node, while a solar eclipse can occur only when the new Moon is near (within 17° 25') either lunar node. Because