Multiple endocrine neoplasia type 1 ATR. The exact function of MEN1 and the protein, menin, produced by this gene is not known, but following the inheritance rules of the "two-hit hypothesis" indicates that it acts as a tumor suppressor. In a diagnostic workup individuals with a combination of endocrine neoplasias suggestive of the "MEN1 syndrome" are recommended to have a mutational analysis of the MEN1 gene if additional diagnostic criteria are sufficiently met, mainly including: Multiple endocrine neoplasia or MEN is part of a group of disorders that affect the body's network of hormone-producing glands (the endocrine system). Hormones are chemical messengers that travel through
Endocrine bone disease Endocrine bone disease An endocrine bone disease is a bone disease associated with a disorder of the endocrine system. An example is osteitis fibrosa cystica. The thyroid, parathyroid, pituitary, or adrenal glands, and the pancreas are parts of the endocrine system, and, therefore are associated with the endocrine bone disease. Some common endocrine disorders are hypothyroidism, hyperthyroidism, Paget’s disease, Osteoporosis, and diabetes. The thyroid gland produces thyroxin (T3, and T4) which is necessary for normal development of the nervous system. Its functions include: promoting growth, increasing basal metabolic rate and controlling body temperature. Adequate iodine intake is necessary for the