Optics which are sensitive to different aspects of light. Rod cells are sensitive to the intensity of light over a wide frequency range, thus are responsible for black-and-white vision. Rod cells are not present on the fovea, the area of the retina responsible for central vision, and are not as responsive as cone cells to spatial and temporal changes in light. There are, however, twenty times more rod cells than cone cells in the retina because the rod cells are present across a wider area. Because of their wider distribution, rods are responsible for peripheral vision. In contrast, cone cells are
Intrinsically photosensitive retinal ganglion cells able to isomerize "all-trans-"retinal into "11-cis-"retinal when stimulated with light without help from additional cells. The two isoforms of melanopsin differ in their spectral sensitivity, for the "11-cis"-retinal isoform is more responsive to shorter wavelengths of light, while the "all-trans" isoform is more responsive to longer wavelengths of light. ipRGCs are both pre- and postsynaptic to dopaminergic amacrine cells (DA cells) via reciprocal synapses, with ipRGCs sending excitatory signals to the DA cells and the DA cells sending inhibitory signals to the ipRGCs. These inhibitory signals are mediated through GABA which is co-released from the DA cells along with dopamine.