Progesterone and is responsible for approximately 70% of cytochrome P450-mediated progesterone metabolism. Other routes include 6α-, 16α-, and 16β-hydroxylation. However, treatment of women with ketoconazole, a strong CYP3A4 inhibitor, had minimal effects on progesterone levels, producing only a slight and non-significant increase, and this suggests that cytochrome P450 enzymes play only a small role in progesterone metabolism. In women, progesterone levels are relatively low during the preovulatory phase of the menstrual cycle, rise after ovulation, and are elevated during the luteal phase, as shown in diagram below. Progesterone levels tend to be less than 2 ng/mL prior to ovulation, and greater
Menstrual synchrony Israel. Twenty seven families, which had from two to seven sisters 13 years or older and collected data on menstrual cycle onsets over a three-month period. Using the methods of, they reported menstrual synchrony occurred for the first two months, but not for the third month for roommate sisters, close friend roommates, and for families as a whole. Strassmann investigated whether menstrual synchrony occurred in a natural fertility population of Dogon village women. Her study consisted of 122 Dogon women with an average lifetime fertility rate of 8.6 ± .3 live births per woman. Their median cycle length was 30