Pleiotropy to have protein. Sickle cell anemia is a genetic disease that causes deformed red blood cells with a rigid, crescent shape instead of the normal flexible, round shape. It is caused by a change in one nucleotide, a point mutation in the HBB gene. The HBB gene encodes information to make the beta-globin subunit of hemoglobin, which is the protein red blood cells use to carry oxygen throughout the body. Sickle cell anemia occurs when the HBB gene mutation causes both beta-globin subunits of hemoglobin to change into hemoglobinS (HbS). Sickle cell anemia is a pleiotropic disease because the expression
Blood donation in England and each donation usually gives two or three adult doses. One adult dose of platelets would otherwise require four whole blood donations. Blood is made in the bone marrow. It is composed of red blood cells, platelets, plasma and white blood cells, collectively referred to as blood components. Donations given at regular blood donation sessions are referred to as "Whole Blood". Platelets are very small cells. They work with the clotting factors in plasma to form a mesh "plug" to stop or prevent bleeding. Plasma is the fluid part of the blood. It contains protein, salts and clotting factors. White