Atrioventricular node Atrioventricular node The atrioventricular node, or AV node is a part of the electrical conduction system of the heart that coordinates the top of the heart. It electrically connects the atria and ventricles. The AV node lies at the lower back section of the interatrial septum near the opening of the coronary sinus, which conducts the normal electrical impulse from the atria to the ventricles. The AV node is quite compact (~1 x 3 x 5 mm). The AV node lies at the lower back section of the interatrial septum near the opening of the coronary sinus, which conducts the
Sinoatrial node hyperpolarisation-activated cyclic nucleotide–gated (HCN) channels, are activated. Activation of these channels at very negative membrane potential is an unusual property for ion channels, therefore the flow of sodium (Na) and some potassium (K) through the activated HCN channel is referred to as a "funny current" (I). This funny current causes the membrane potential of the cell to gradually increase, as the positive charge (Na and K) is flowing into the cell. Another mechanism involved in pacemaker potential is known as the calcium clock. Here, calcium is released spontaneously from the sarcoplasmic reticulum (a calcium store) into the cell, this is