Maurice Wilkins by James Watson. During the second phase, 1951–52, Wilkins produced clear "B form" "X" shaped images from squid sperm, images he sent to James Watson and Francis Crick, causing Watson to write "Wilkins... has obtained extremely excellent X-ray diffraction photographs" [of DNA]. In 1953 Wilkins' colleague Rosalind Franklin instructed Raymond Gosling to hand over to Wilkins a high quality image of "B" form DNA ("Photo 51"), which she had made in 1952 but had “put it aside” as she was leaving King's College London. Wilkins showed it to Watson. This image, along with the knowledge that Linus Pauling had proposed
History of molecular biology with the work being done on DNA in the early 1950s. In their seminal 1953 paper, Watson and Crick suggested that van der Waals crowding by the 2`OH group of ribose would preclude RNA from adopting a double helical structure identical to the model they proposed - what we now know as B-form DNA. This provoked questions about the three-dimensional structure of RNA: could this molecule form some type of helical structure, and if so, how? As with DNA, early structural work on RNA centered around isolation of native RNA polymers for fiber diffraction analysis. In part because of heterogeneity