Rostral ventrolateral medulla spinal cord via reticulospinal tract. Physostigmine, a choline-esterase inhibitor, elevates endogenous levels of acetylcholine and causes a rise in blood pressure by stimulation of the RVLM. Orexinergic neurons from the lateral hypothalamus output in the RVLM. Rostral ventrolateral medulla The rostral ventrolateral medulla (RVLM), also known as the pressor area of the medulla, is a brain region that is responsible for basal and reflex control of sympathetic activity associated with cardiovascular function. Abnormally elevated sympathetic activity in the RVLM is associated with various cardiovascular diseases, such as heart failure and hypertension. The RVLM is notably involved in the baroreflex. It
Anterior median fissure of the medulla oblongata Anterior median fissure of the medulla oblongata The anterior median fissure (ventral or ventromedian fissure) contains a fold of pia mater, and extends along the entire length of the medulla oblongata: It ends at the lower border of the pons in a small triangular expansion, termed the foramen cecum. Its lower part is interrupted by bundles of fibers that cross obliquely from one side to the other, and constitute the pyramidal decussation. Some fibers, termed the anterior external arcuate fibers, emerge from the fissure above this decussation and curve lateralward and upward over the surface of the medulla oblongata to