Versican other inflammatory cells) can migrate more easily through extracellular matrix that has a higher versican content. Deposits of versican are not present in normal skin but are found in the reticular dermis during keloid scarring, a condition where scar formation becomes uncontrolled and overgrowth of skin tissue occurs at the site of the wound. Versican has been shown to interact with hyaluronan and a link protein (hyaluronan and proteoglycan link protein 1; HAPLN1). Versican Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the "VCAN" gene. Versican is a
Scar Tissue Co-written by Larry Sloman, it was an autobiography with the principal theme of sex, drugs and rock-'n-roll. In the book he talks about the consequences of drugs (especially heroin) and in which way this can destroy somebody's life. The music video for "Scar Tissue" was directed by Stéphane Sednaoui, who also directed the video for "Give It Away". The opening shot is of John Frusciante driving down a strip of desert highway, a metaphor for Frusciante's return to the band (he does not drive in real life). But the four of them are battered, beaten and bandaged. They are traveling