Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Ties of Blood and Water Ties of Blood and Water "Ties of Blood and Water" is an episode of the syndicated American science fiction television series "", the nineteenth episode of the . Set in the 24th century, the series follows the adventures on "Deep Space Nine", a space station located near a stable wormhole between the Alpha and Gamma quadrants of the Milky Way Galaxy. In this episode, Major Kira (Nana Visitor) must deal with her feelings over the impending death of her friend Tekeny Ghemor (Lawrence Pressman) as she takes notes from him as he reveals secrets about the Cardassian Union and the