Effect of spaceflight on the human body of muscle fibre prominent in muscles also change. Slow twitch endurance fibres used to maintain posture are replaced by fast twitch rapidly contracting fibres that are insufficient for any heavy labour. Advances in research on exercise, hormone supplements and medication may help maintain muscle and body mass. Bone metabolism also changes. Normally, bone is laid down in the direction of mechanical stress. However, in a microgravity environment there is very little mechanical stress. This results in a loss of bone tissue approximately 1.5% per month especially from the lower vertebrae, hip and femur. Due to microgravity and the decreased load
Bone resorption in the resorption process. High levels of calcium, magnesium, phosphate and products of collagen will be released into the extracellular fluid as the osteoclasts tunnel into the mineralized bone. Osteoclasts are prominent in the tissue destruction found in psoriatic arthritis and rheumatological disorders. The human body is in a constant state of bone remodeling. Bone remodelling is a process which maintains bone strength and ion homeostasis by replacing discrete parts of old bone with newly synthesized packets of proteinaceous matrix. Bone is resorbed by osteoclasts, and is deposited by osteoblasts in a process called ossification. Osteocyte activity plays a key