Vitamin and C dissolve into the water when a vegetable is boiled, and are then lost when the water is discarded. The body's stores for different vitamins vary widely; vitamins A, D, and B are stored in significant amounts, mainly in the liver, and an adult's diet may be deficient in vitamins A and D for many months and B in some cases for years, before developing a deficiency condition. However, vitamin B (niacin and niacinamide) is not stored in significant amounts, so stores may last only a couple of weeks. For vitamin C, the first symptoms of scurvy in experimental
Holocarboxylase synthetase deficiency Holocarboxylase synthetase deficiency Holocarboxylase synthetase deficiency is an inherited metabolic disorder in which the body is unable to use the vitamin biotin effectively. This disorder is classified as a multiple carboxylase deficiency, a group of disorders characterized by impaired activity of certain enzymes that depend on biotin. Symptoms are very similar to biotinidase deficiency and treatment – large doses of biotin – is also the same. Mutations in the "HLCS" gene cause holocarboxylase synthetase deficiency. The "HLCS" gene makes an enzyme, holocarboxylase synthetase, that attaches biotin to other molecules. Biotin, a B vitamin, is found in foods such as liver,