Ear pain with several weeks of IV and oral antibiotics, usually fluoroquinolones. Acute otitis media is an infection of the middle ear. More than 80% of children experience at least one episode of otitis media by age 3 years. Acute otitis media is also most common in these first 3 years of life, though older children may also experience it. The most common causative bacteria are "Streptococcus pneumoniae", "Haemophilus influenzae", and "Moraxella catarrhalis". Otitis media often occurs with or following cold symptoms. The diagnosis is made by the combination of symptoms and examination of the tympanic membrane for redness, bulging, and/or a
Integral membrane protein at atomic resolution by X-ray crystallography or nuclear magnetic resonance spectroscopy. They are challenging subjects for study owing to the difficulties associated with extraction and crystallization. In addition, structures of many water-soluble protein domains of IMPs are available in the Protein Data Bank. Their membrane-anchoring α-helices have been removed to facilitate the extraction and crystallization. Search integral membrane proteins in the PDB (based on gene ontology classification) IMPs can be divided into two groups: The most common type of IMP is the transmembrane protein (TM), which spans the entire biological membrane. Single-pass membrane proteins cross the membrane only once, while