Vitamin and C dissolve into the water when a vegetable is boiled, and are then lost when the water is discarded. The body's stores for different vitamins vary widely; vitamins A, D, and B are stored in significant amounts, mainly in the liver, and an adult's diet may be deficient in vitamins A and D for many months and B in some cases for years, before developing a deficiency condition. However, vitamin B (niacin and niacinamide) is not stored in significant amounts, so stores may last only a couple of weeks. For vitamin C, the first symptoms of scurvy in experimental
Vitamin A deficiency conjunctiva, known as Bitot's spots, can be seen. ; Imtiaz's sign is the earliest ocular sign of VAD. Conjunctival epithelial defects occur around lateral aspect of the limbus in the subclinical stage of VAD. These conjunctival epithelial defects are not visible on a biomicroscope, but they take up black stain and become readily visible after instillation of kajal (surma); this is called "Imtiaz's sign". VAD can also lead to impaired immune function, cancer, and birth defects. Vitamin A deficiency is one of several hypovitaminoses implicated in follicular hyperkeratosis. Night blindness is the difficulty for the eyes to adjust to dim