Pituitary gland secretes hormones. All releasing hormones (-RH) referred to, can also be referred to as releasing factors (-RF). Somatotropes: Corticotropes: Thyrotropes: Gonadotropes: Lactotropes: These hormones are released from the anterior pituitary under the influence of the hypothalamus. Hypothalamic hormones are secreted to the anterior lobe by way of a special capillary system, called the hypothalamic-hypophysial portal system. There is also a non-endocrine cell population called folliculostellate cells. The intermediate lobe synthesizes and secretes the following important endocrine hormone: The posterior pituitary stores and secretes (but does not synthesize) the following important endocrine hormones: Magnocellular neurons: Hormones secreted from the pituitary gland
Pituitary adenoma interacting protein" ("AIP") gene , and duplications in chromosome Xq26.3 that include the "GPR101" gene that also causes X-linked acrogigantism (X-LAG) syndrome. About 15-20% of FIPA families carry a germline "AIP" gene mutation or deletion, and the disease occurs as autosomal dominant with incomplete penetrance, meaning that about 20% of AIP mutation carriers will develop a pituitary adenoma. "AIP" mutation associated pituitary adenomas (either presenting as FIPA or as individual, non familial cases) are usually growth hormone secreting (acromegaly) or prolactin secreting (prolactinoma) adenomas that are large (macroadenomas) and often occur in children, adolescents and young adults. Daly and colleagues