Allergic inflammation immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema. The late phase of a Type 1 reaction (which develops 8–12
Is the Is Are substance," following an incident in which their car was pulled over by the police, en route to the Basilica Music Festival. Smith stated that the incident greatly influenced the writing and recording of "Is the Is Are": "What happened to us was really shitty and traumatic, and it wasn’t something I did to get attention — it was the worst possible thing that could have happened at that moment. I knew it was going to take a really good album to save me. That’s what made it so hard to write, and why it took so long. If I didn’t