Androgen receptor the development and maintenance of the male sexual phenotype. In some cell types, testosterone interacts directly with androgen receptors, whereas, in others, testosterone is converted by 5-alpha-reductase to dihydrotestosterone, an even more potent agonist for androgen receptor activation. Testosterone appears to be the primary androgen receptor-activating hormone in the Wolffian duct, whereas dihydrotestosterone is the main androgenic hormone in the urogenital sinus, urogenital tubercle, and hair follicles. Hence, testosterone is responsible primarily for the development of male primary sexual characteristics, whereas dihydrotestosterone is responsible for secondary male characteristics. Androgens cause slow epiphysis, or maturation of the bones, but more of
Sexual arousal role in determining how a person will respond in any given sexual situation. On the other hand, a person may be hypersexual, which is a desire to engage in sexual activities considered abnormally high in relation to normal development or culture, or suffering from a persistent genital arousal disorder, which is a spontaneous, persistent, and uncontrollable arousal, and the physiological changes associated with arousal. Sexual arousal causes various physical responses, most significantly in the sex organs (genital organs). Sexual arousal for a man is usually indicated by the swelling and erection of the penis when blood fills the corpus cavernosum.