Pharmacodynamics of progesterone women, this effect being the result of suppression of the mid-cycle surge in gonadotropin secretion, is 300 mg/day. However, this figure is based on limited clinical data. Conversely, treatment with a high dosage of oral progesterone of 100 mg four times per day (or 400 mg/day total) in men for 10 days that resulted in approximately mid-luteal phase levels of progesterone (7.9–9.4 ng/mL; measured by ) did not cause any change in testosterone levels, suggesting that progesterone has little or no antigonadotropic effect in males at typical clinical dosages. In addition, a study found that administration of 1,000 mg/day oral
Menstrual synchrony one menstrual onset for each woman in a couple, they calculated the degree of synchrony. They reported that more than half of the couples had synchronized within a two-day timespan of each other. Trevathan, Burleson, and Gregory also conducted a study with 29 lesbian couples (22 to 48 years of age), but they incorporated the methodological critique of Wilson into the design of their study. In particular, Wilson emphasized the importance of using actual menstrual cycle lengths with their inherent variability. The lesbian couples were drawn from a larger sample of women who had kept daily records of their menstrual