Gonadal dysgenesis If a single or combination of these genes are mutated or deleted, downstream signalling is disrupted, leading to malformation of male external genitalia. SRY acts on gene SOX9 which drives Sertoli cell formation and testis differentiation. An absence in SRY causes SOX9 to not be expressed at the appropriate time or concentration, leading to a deficiency in testosterone and Anti-Müllerian hormone production. Inadequate levels of testosterone and Anti-Müllerian hormone disrupts the development of Wolffian ducts and internal genitalia that are key to male reproductive tract development. The lack of the male associated steroid hormones drives Müllerian duct development and perusal
Human male sexuality with a male, and decrease the chance that the female will mate with another male. There are several strategies by which sexual coercion can be achieved. These are harassment, intimidation, and forced copulation (rape). Thornhill and Palmer's "A Natural History of Rape" investigates the evolutionary causes of sexual coercion, particularly of rape, and suggest that such behaviour is a result of sexual selection, rather than Darwinian natural selection. Of ten listed hypotheses, they accepted two reasonable hypotheses: Thornhill and Palmer argue that these two theories are the strongest of the ten for several reasons. For example, both hypothesis argue rape