Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
Achilles tendon the bone; the gap is filled up with areolar and adipose tissue. A bursa lies between the tendon and the upper part of the calcaneus. It is about long. Along the side of the muscle, and superficial to it, is the small saphenous vein. The sural nerve the outer border of the tendon about 10cm below where it attaches to the bone. The tendon is the thickest tendon in the human body. It can receive a load stress 3.9 times body weight during walking and 7.7 times body weight when running. The blood supply to the Achilles tendon is poor,