Allergic inflammation immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema. The late phase of a Type 1 reaction (which develops 8–12
Aeroallergen Aeroallergen An aeroallergen ("pronounced aer·o·al·ler·gen") is any airborne substance, such as pollen or spores, which triggers an allergic reaction. Aeroallergens include the pollens of specific seasonal plants is commonly known as "hay fever", because it is most prevalent during haying season, from late May to the end of June in the Northern Hemisphere; but it is possible to suffer from hay fever throughout the year. The pollen which causes hay fever varies from person to person and from region to region; generally speaking, the tiny, hardly visible pollens of wind-pollinated plants are the predominant cause. Pollens of insect-pollinated plants are