State microbe is noteworthy because it is: the first significant antibiotic discovered after penicillin; the first systemic antibiotic discovered in America; the first antibiotic active against tuberculosis; first-line treatment for plague. Moreover, New Jersey was the home of Selman Waksman, who was awarded the Nobel Prize in Physiology or Medicine for his systematic studies of antibiotic production by "S. griseus" and other soil microbes. On May 15, 2017, Senate Bill 3190 (S3190) was introduced by Senator Samuel D. Thompson (R-12); the bill designates "Streptomyces griseus" as the New Jersey State Microbe, to be added to the state's other state symbols. On June
Quinolone antibiotic with urinary catheters. In community-acquired infections, they are recommended only when risk factors for multidrug resistance are present or after other antibiotic regimens have failed. However, for serious acute cases of pyelonephritis or bacterial prostatitis where the person may need to be hospitalised, fluoroquinolones are recommended as first-line therapy. Due to people with sickle-cell disease being at increased risk for developing osteomyelitis from the "Salmonella", fluoroquinolones are the "drugs of choice" due to their ability to enter bone tissue without chelating it, as tetracyclines are known to do. Fluoroquinolones are featured prominently in guidelines for the treatment of hospital-acquired pneumonia.