Antibiotic synergy with enterococcal endocarditis experienced a high relapse rate when penicillin G alone was used for treatment and a demonstrably lower relapse rate when streptomycin was combined with penicillin G to combat the infection. Since that time the research community has conducted numerous studies regarding the effects and possibilities of antibiotic combinations. Today, combination therapy is recognized as providing a broad spectrum of antibiotic coverage, effectively fighting polymicrobial infections, minimizing selection for antibiotic resistant strains, lowering dose toxicity where applicable, and in some cases providing synergistic activity. Antibiotic synergy is desirable in a clinic sense for several reasons. At the patient
Antibiotic resistance in gonorrhea the "parC" gene which encodes for the topoisomerase IV. Topoisomerase IV acts similarly to DNA gyrase and is involved in unwinding DNA for replication. Ceftriaxone and cefixime are third generation cephalosporins and are often used as treatments for "N. gonorrhoeae infections". The cephalosporins are part of a larger beta-lactam family of antibiotics. The newly discovered H041 strain of "N. gonorrhoeae", originally isolated from a commercial sex worker in Japan, was shown to be resistant to this antibiotic. The possible mechanisms of resistance to this antibiotic are as follows: Tetracyclines are a class of antibiotics that inhibit protein synthesis by binding