Androgen receptor the development and maintenance of the male sexual phenotype. In some cell types, testosterone interacts directly with androgen receptors, whereas, in others, testosterone is converted by 5-alpha-reductase to dihydrotestosterone, an even more potent agonist for androgen receptor activation. Testosterone appears to be the primary androgen receptor-activating hormone in the Wolffian duct, whereas dihydrotestosterone is the main androgenic hormone in the urogenital sinus, urogenital tubercle, and hair follicles. Hence, testosterone is responsible primarily for the development of male primary sexual characteristics, whereas dihydrotestosterone is responsible for secondary male characteristics. Androgens cause slow epiphysis, or maturation of the bones, but more of
Asia Pacific Coalition on Male Sexual Health Nations officials. Its mission is to assist local organizations in advocacy for the rights of MSMs and transgender males. Asia Pacific Coalition on Male Sexual Health The Asia Pacific Coalition on Male Sexual Health, also known as APCOM, is a network of non-profit organizations which share the mission of improving male sexual health in South Asia, East Asia, and the Pacific Islands. APCOM was launched in July 2007 after delegates to the Delhi 2006 International Consultation on Male Sexual Health and HIV in Asia and the Pacific identified a need for more organization in the field of male sexual health.