Stimulus modality lit area, the eyes require time for a good quantity of rhodopsin to regenerate. As more time passes, there is a higher chance that the photons will split an unbleached photopigment because the rate of regeneration will have surpassed the rate of bleaching. This is called adaptation. Humans are able to see an array of colours because light in the visible spectrum is made up of different wavelengths (from 380 to 760 nm). Our ability to see in colour is due to three different cone cells in the retina, containing three different photopigments. The three cones are each specialized to
Gene therapy of the human retina and RPE layer, in a short surgical procedure. Although this is more invasive than the intravitreal route, the fluid is absorbed by the RPE and the retina flattens in less than 14 hours without complications. Intravitreal AAV targets retinal ganglion cells and a few Muller glial cells. Subretinal AAV efficiently targets photoreceptors and RPE cells. The reason that different routes of administration lead to different cell types being transfected (e.g., different tropism) is that the inner limiting membrane (ILM) and the various retinal layers act as physical barriers for the delivery of drugs and vectors to the deeper retinal layers.