Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
Acid rock Acid rock Acid rock is a loosely defined type of rock music that evolved out of the mid-1960s garage punk movement and helped launch the psychedelic subculture. The style is generally defined by heavy, distorted guitars, lyrics with drug references, and long improvised jams. Its distinctions from other genres can be tenuous, as much of the style overlaps with '60s punk, proto-metal, and early heavy, blues-based hard rock. The term, which derives its name from lysergic acid diethylamide (LSD), is sometimes used interchangeably with "psychedelic rock", but may refer more specifically to a more musically intense subgenre or sibling to