Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Water organ these only the one at the Palazzo del Quirinale has survived. Kircher's illustration in "Musurgia universalis" (1650), long thought to be a fanciful representation of a hypothetical possibility, has been found to be accurate in every detail when compared to the organ grotto at the Quirinale, except that it was reversed left to right. There are still traces of the instrument at the Villa d'Este but the mineral-rich water of the river which cascades through the organ grotto has caused accretions which have hidden most of the evidence from view. In the early 17th century, water organs were built in