Glycogen of glucose-1-phosphate: In vivo, phosphorolysis proceeds in the direction of glycogen breakdown because the ratio of phosphate and glucose-1-phosphate is usually greater than 100. Glucose-1-phosphate is then converted to glucose 6-phosphate (G6P) by phosphoglucomutase. A special debranching enzyme is needed to remove the α(1-6) branches in branched glycogen and reshape the chain into a linear polymer. The G6P monomers produced have three possible fates: The most common disease in which glycogen metabolism becomes abnormal is diabetes, in which, because of abnormal amounts of insulin, liver glycogen can be abnormally accumulated or depleted. Restoration of normal glucose metabolism usually normalizes glycogen
Metropolitan Stores wholly owned Canadian subsidiary of Metropolitan Stores Ltd. to investment bankers James Richardson & Sons Ltd. of Winnipeg, Manitoba for approximately $19 million in cash, which returned the company to 100 per cent Canadian ownership. The agreement brought 86 stores and one warehouse located mainly in Ontario, Quebec and Winnipeg with annual sales in excess of $20 million and an annual profit after taxes of more than $1 million. Following the purchase, James Richardson & Sons transferred the business of Metropolitan Stores Ltd. to a newly formed Canadian corporation that became known as Metropolitan Stores of Canada Ltd. Two months