Transgender hormone therapy (male-to-female) medical professional. Inducers of CYP3A4 and other cytochrome P450 enzymes can reduce the effects of MTF HRT. A variety of different sex-hormonal medications are used in feminizing hormone therapy for transgender women. These include estrogens to induce feminization and suppress testosterone levels; antiandrogens such as androgen receptor antagonists, antigonadotropins, GnRH modulators, and 5α-reductase inhibitors to further oppose the effects of androgens like testosterone; and progestogens for various possible though uncertain benefits. Estrogens are the major sex hormones in women, and are responsible for the development and maintenance of feminine secondary sexual characteristics, such as breasts, wide hips, and a feminine
Sexual frustration For males it could be that they have testicles and no penis; a male might be born without a penis (aphallia) or be born with one and have it removed (penis removal or penectomy). Men can still ejaculate via prostate stimulation in that case. For females they might not have a clitoris which causes sexual pleasure; a female might have had her clitoris forcibly severed (female genital mutilation) or voluntarily removed (female circumcusion) as part of a medical procedure. Involuntary celibacy is a form of sexual frustration. Sexual frustration Sexual frustration in humans is frustration caused by a discrepancy between