Gonadal dysgenesis If a single or combination of these genes are mutated or deleted, downstream signalling is disrupted, leading to malformation of male external genitalia. SRY acts on gene SOX9 which drives Sertoli cell formation and testis differentiation. An absence in SRY causes SOX9 to not be expressed at the appropriate time or concentration, leading to a deficiency in testosterone and Anti-Müllerian hormone production. Inadequate levels of testosterone and Anti-Müllerian hormone disrupts the development of Wolffian ducts and internal genitalia that are key to male reproductive tract development. The lack of the male associated steroid hormones drives Müllerian duct development and perusal
Sexual Preference (book) that while Bell "et al."′s suggestion that biological factors have a stronger influence on exclusive homosexuality than they have on bisexuality may seem plausible, it has not been directly tested and appears to conflict with available evidence, such as that concerning prenatal hormone exposure. The psychologist Bruce Rind credited Bell "et al." with disproving psychoanalytic theories about the development of homosexuality, along with the idea that childhood seduction causes homosexuality. The psychologist Mark Yarhouse wrote that while "Sexual Preference" is cited by proponents of a biological explanation, it relies on retrospective memory recall, which can be unreliable. The psychologist J.