Nav1.5 kb. The gene consists of 28 exons, of which exon 1 and in part exon 2 form the 5’ untranslated region (5’UTR) and exon 28 the 3’ untranslated region (3’UTR) of the RNA. SCN5A is part of a family of 10 genes that encode different types of sodium channels, i.e. brain-type (Na1.1, Na1.2, Na1.3, Na1.6), neuronal channels (Na1.7, Na1.8 and Na1.9), skeletal muscle channels (Na1.4) and the cardiac sodium channel Na1.5. SCN5A is mainly expressed in the heart, where expression is abundant in working myocardium and conduction tissue. In contrast, expression is low in the sinoatrial node and atrioventricular node.
Longitude of the ascending node Longitude of the ascending node The longitude of the ascending node (☊ or Ω) is one of the orbital elements used to specify the orbit of an object in space. It is the angle from a reference direction, called the "origin of longitude", to the direction of the ascending node, measured in a reference plane. The ascending node is the point where the orbit of the object passes through the plane of reference, as seen in the adjacent image. Commonly used reference planes and origins of longitude include: In the case of a binary star known only from visual observations,