Glycolysis involved in glycolysis. The burning sensation in muscles during hard exercise can be attributed to the release of hydrogen ions during the shift to glucose fermentation from glucose oxidation to carbon dioxide and water, when aerobic metabolism can no longer keep pace with the energy demands of the muscles. These hydrogen ions form a part of lactic acid. The body falls back on this less efficient but faster method of producing ATP under low oxygen conditions. This is thought to have been the primary means of energy production in earlier organisms before oxygen reached high concentrations in the atmosphere between
Arteriovenous oxygen difference diff. The maximum a-vO diff is also usually greater in trained athletes than in untrained individuals. This is a result of aerobic exercise leading to hypertrophy of the slow twitch muscle fibres mainly due to increased capillarisation. The increase in capillary beds in the muscle means that blood supply to that muscle can be greater and diffusion of oxygen, carbon dioxide, and other metabolites increases. With training the muscles also improve in their ability to extract oxygen from the blood and process the oxygen, possibly due to adaptations of the mitochondria and an increase in the muscle's myoglobin content. Research