Nonsteroidal anti-inflammatory drug more effective than salicin and, in addition to its fever-reducing properties, is anti-inflammatory and analgesic. In 1869, Hermann Kolbe synthesised salicylate, although it was too acidic for the gastric mucosa. The reaction used to synthesise aromatic acid from a phenol in the presence of CO2 is known as the Kolbe-Schmitt reaction. By 1897 the German chemist Felix Hoffmann and the Bayer company prompted a new age of pharmacology by converting salicylic acid into acetylsalicylic acid—named aspirin by Heinrich Dreser. Other NSAIDs were developed from the 1950s forward. In 2001, NSAIDs accounted for 70,000,000 prescriptions and 30 billion over-the-counter doses sold
Acid Tests Acid Tests The Acid Tests were a series of parties held by author Ken Kesey primarily in the San Francisco Bay Area during the mid-1960s, centered entirely on the use of, and advocacy of, the psychedelic drug LSD, also known as "acid". LSD-25 was not made illegal in California until October 6, 1966. The name "Acid Test" was coined by Kesey, after the term "acid test" used by gold miners in the 1850s. He began throwing parties at his farm at La Honda, California. The Merry Pranksters were central to organizing the Acid Tests, including Pranksters such as Lee Quarnstrom