Free-radical halogenation distribution". For propane and higher alkanes, the hydrogen atoms which form part of CH (or CH) groups are preferentially replaced. The reactivity of the different halogens varies considerably. The relative rates are: fluorine (108) > chlorine (1) > bromine (7 × 10) > iodine (2 × 10). Hence, the reaction of alkanes with fluorine is difficult to control, that with chlorine is moderate to fast, that with bromine is slow and requires high levels of UV irradiation while the reaction with iodine is practically nonexistent and thermodynamically unfavorable. A common method in organic synthesis employing is the Wohl–Ziegler reaction, which
Biological aspects of fluorine Biological aspects of fluorine Biological aspects of fluorine describes the effects of fluorine-containing compounds with life. Fluorine (F) itself is very rare in everyday life, but hundreds of fluorine-containing compounds occur as minerals, medicines, pesticides, and materials. Naturally occurring organofluorine compounds are extremely rare. Nonetheless, twenty percent of all commercialized pharmaceuticals contain fluorine, examples being Lipitor and Prozac. Manmade fluorinated compounds have also played a role in several noteworthy environmental concerns. Chlorofluorocarbons, once major components of numerous commercial aerosol products, have proven damaging to Earth's ozone layer and resulted in the wide-reaching Montreal Protocol (though in truth the chlorine in