Allergic inflammation immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema. The late phase of a Type 1 reaction (which develops 8–12
The Sleep of Reason Produces Monsters Miller novel "Pure", as well as the 2017 album by Swedish metal band Meshuggah, entitled "The Violent Sleep of Reason." Also the names of Finnish occult metal band Sleep of Monsters and their first album, "Produces Reason" derive from the name of the title. Occasionally the title phrase is rendered as "The dream of reason produces monsters", since the Spanish word "sueño" can mean either "sleep" or "dream". However, Goya's epigraph makes it clear that his intended interpretation is "the sleep of reason". The Sleep of Reason Produces Monsters __notoc__ The Sleep of Reason Produces Monsters () is an etching