Muscarinic antagonist brain, involving both increased levels of acetylcholine and degeneration of dopaminergic pathways (nigrostriatal pathway). Thus, in parkinsonism there is decreased level of dopaminergic activity. One method of balancing the neurotransmitters is through blocking central cholinergic activity using muscarinic receptor antagonists. Atropine acts on the M2 receptors of the heart and antagonizes the activity of acetylcholine. It causes tachycardia by blocking vagal effects on the sinoatrial node. Acetylcholine hyperpolarizes the sinoatrial node, which is overcome by MRA and thus increases the heart rate. If atropine is given by intramuscular or subcutaneous injection, it causes initial bradycardia. This is because by i.m/s.c
Longitude of the ascending node Longitude of the ascending node The longitude of the ascending node (☊ or Ω) is one of the orbital elements used to specify the orbit of an object in space. It is the angle from a reference direction, called the "origin of longitude", to the direction of the ascending node, measured in a reference plane. The ascending node is the point where the orbit of the object passes through the plane of reference, as seen in the adjacent image. Commonly used reference planes and origins of longitude include: In the case of a binary star known only from visual observations,