Allergic inflammation immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema. The late phase of a Type 1 reaction (which develops 8–12
Double Allergic space. Powderfinger spent less money producing "Double Allergic" than on their previous works. Previously, the band had worked with Tony Cohen, whom Fanning stated was expensive due to his success in the industry. For "Double Allergic" the band chose Tim Whitten, a less well known producer, and because the band knew what they intended to do as they entered the studio they managed to spend less despite the improved sound. Middleton commented on Whitten's capabilities in the recording studio, saying "He's what a band looks for in a producer/engineer, because he's got his own ideas", but stating that Whitten would