Glycogen branching enzyme leads to increased osmotic pressure resulting in cellular swelling and death. The tissues most affected by this disease are the liver, heart, and neuromuscular system, areas with the greatest levels of glycogen accumulation. Abnormal glycogen buildup in the liver interferes with liver functioning and can result in an enlarged liver and liver disease. In muscles, the inability of cells to efficiently breakdown glycogen due to the severe reduction or absence of branching can lead to muscle weakness and atrophy. At least three mutations in the GBE1 gene have been found to cause another disease called adult polyglucosan body disease (APBD).
Love in Excess; or, The Fatal Enquiry included several prefatory poems. The poems flatter Haywood's narrative skills and her ability to present "the power of physical and emotional love". The poems that were published in the early editions praised "Love in Excess", but in the 6 edition, they also noticed Haywood's body of work, suggesting her higher reputation as a writer. Positive reaction to her work influenced more women to publish. (109-110) Love in Excess; or, The Fatal Enquiry Love in Excess (1719–1720) is Eliza Haywood's best known novel. It details the amorous escapades of Count D'Elmont, a rake who becomes reformed over the course of the