Nav1.5 kb. The gene consists of 28 exons, of which exon 1 and in part exon 2 form the 5’ untranslated region (5’UTR) and exon 28 the 3’ untranslated region (3’UTR) of the RNA. SCN5A is part of a family of 10 genes that encode different types of sodium channels, i.e. brain-type (Na1.1, Na1.2, Na1.3, Na1.6), neuronal channels (Na1.7, Na1.8 and Na1.9), skeletal muscle channels (Na1.4) and the cardiac sodium channel Na1.5. SCN5A is mainly expressed in the heart, where expression is abundant in working myocardium and conduction tissue. In contrast, expression is low in the sinoatrial node and atrioventricular node.
Node (physics) the ratio of the amplitude of the wave at the antinode to the amplitude at the node. In resonance of a two dimensional surface or membrane, such as a drumhead or vibrating metal plate, the nodes become nodal lines, lines on the surface where the surface is motionless, dividing the surface into separate regions vibrating with opposite phase. These can be made visible by sprinkling sand on the surface, and the intricate patterns of lines resulting are called Chladni figures. In transmission lines a voltage node is a current antinode, and a voltage antinode is a current node. Nodes are