Prodrug not its intended target. This reduces adverse or unintended effects of a drug, especially important in treatments like chemotherapy, which can have severe unintended and undesirable side effects. Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone. For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. However, in other cases, such as codeine and morphine,
A Is for Acid A Is for Acid A Is for Acid is a 2002 British television film based on the life of the serial killer John George Haigh, known as the Acid Bath Murderer, because he dissolved the bodies of six people in sulphuric acid. Haigh, hanged in 1949 for his crimes, had wrongly believed that murder could not be proven without the presence of a body. Starring Martin Clunes in the lead role, the film was shot in Scarborough, chosen because its appearance was believed similar to that of London when Haigh lived there during the 1940s. The film was produced by