Blood gas tension Blood gas tension Blood gas tension refers to the partial pressure of gases in blood. There are several significant purposes for measuring gas tension; the most common gas tensions measured are oxygen tension (PO), the carbon dioxide tension (PCO) and carbon monoxide tension (PCO). The subscript "x" in each symbol represents the source of the gas being measured; ""a"" meaning arterial, ""A"" being alveolar, ""v"" being venous, ""c"" being capillary. Blood gas tests (such as arterial blood gas tests) measure these partial pressures. PO – Partial pressure of oxygen at sea level (765 mmHg) in arterial blood is between 75
Fetal hemoglobin is encoded on chromosome 11, as is the beta subunit. There are two similar copies of the gamma subunit gene: γG which has a glycine at position 136, and γA which has an alanine. The gene that codes for the alpha subunit is located on chromosome 16 and is also present in duplicate. When fetal hemoglobin production is switched off after birth, normal children begin producing adult hemoglobin (HbA). Children with sickle-cell disease instead begin producing a defective form of hemoglobin called hemoglobin S which aggregates together and forms filaments that cause red blood cells to change their shape from