Acetyl group known as paracetamol), and acetylsalicylic acid (better known as aspirin). The introduction of an acetyl group into a molecule is called acetylation. In biological organisms, acetyl groups are commonly transferred from acetyl-CoA to other organic molecules. Acetyl-CoA is an intermediate both in the biological synthesis and in the breakdown of many organic molecules. Acetyl-CoA is also created during the second stage of cellular respiration, the Krebs Cycle, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation. For example, on the DNA level, histone acetylation by acetyltransferases (HATs) causes an expansion of
Worse is better Rise of Worse is Better", Gabriel claimed that "Worse-is-Better" is a model of software design and implementation which has the following characteristics (in approximately descending order of importance): Gabriel argued that early Unix and C, developed by Bell Labs, are examples of this design approach. Gabriel contrasted his philosophy with what he called the "MIT/Stanford style of design" or "MIT approach" (also known as "the Right Thing"), which he described as follows. Contrasts are in bold: Gabriel argued that "Worse is better" produced more "successful" software than the MIT approach: As long as the initial program is basically good, it