Valerian (herb) particular binding site. Hydrophilic extractions of the herb commonly sold over the counter, however, probably do not contain significant amounts of isovaltrate. Valerenic acid in valerian stimulates serotonin receptors as a partial agonist, including 5-HT which is implicated in the sleep-wake cycle. The chief constituent of valerian is a yellowish-green to brownish-yellow oil present in the dried root, varying in content from 0.5 to 2.0%. This variation in quantity may be determined by location; a dry, stony soil yields a root richer in oil than moist, fertile soil. The volatile oils that form the active ingredient are pungent, somewhat reminiscent
Valerian (herb) of well-matured cheese. Though some people remain partial to the earthy scent, some find it unpleasant, comparing the odor to that of unwashed feet. Although valerian is a common traditional medicine used for treating insomnia, there is no good evidence it is effective for this purpose, and there is some concern it may be harmful. Valerian is not helpful in treating restless leg syndrome or anxiety. There is insufficient evidence for efficacy and safety of valerian for anxiety disorders. The European Medicines Agency (EMA) approved the health claim that valerian can be used as a traditional herbal medicine to relieve