Acetyl group known as paracetamol), and acetylsalicylic acid (better known as aspirin). The introduction of an acetyl group into a molecule is called acetylation. In biological organisms, acetyl groups are commonly transferred from acetyl-CoA to other organic molecules. Acetyl-CoA is an intermediate both in the biological synthesis and in the breakdown of many organic molecules. Acetyl-CoA is also created during the second stage of cellular respiration, the Krebs Cycle, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation. For example, on the DNA level, histone acetylation by acetyltransferases (HATs) causes an expansion of
U Should've Known Better producers, which included Dallas Austin, production team Soulshock & Karlin, Bryan Michael Cox, and Rodney Jerkins and his Darkchild crew. Though she "had never thought about writing much" by then, her producers encouraged the singer to intensify her work on the "All Eyez on Me" album and to write and contribute own lyrics and ideas to the songs, one of which was the ballad "U Should've Known Better." Monica penned the song along with Harold Lilly and longtime contributor Jermaine Dupri, while production on the track was helmed by Dupri and Bryan Michael Cox. "U Should've Known Better" was mixed