Myringoplasty perforation and a small part should also extend over the posterior canal wall. The tympanomeatal flap is then replaced. The temporal fascia is harvested. An incision is made to raise medial meatal skin with tympanic membrane epithelium. The graft is placed on the outer surface of the tympanic membrane and a slit is made to tuck it under the handle of malleus. The ear is packed with gelfoam and antibiotics, and the incision is closed. Finally mastoid dressing is performed. Myringoplasty Myringoplasty is the closure of the perforation of pars tensa of the tympanic membrane. When myringoplasty is combined with
Integral membrane protein at atomic resolution by X-ray crystallography or nuclear magnetic resonance spectroscopy. They are challenging subjects for study owing to the difficulties associated with extraction and crystallization. In addition, structures of many water-soluble protein domains of IMPs are available in the Protein Data Bank. Their membrane-anchoring α-helices have been removed to facilitate the extraction and crystallization. Search integral membrane proteins in the PDB (based on gene ontology classification) IMPs can be divided into two groups: The most common type of IMP is the transmembrane protein (TM), which spans the entire biological membrane. Single-pass membrane proteins cross the membrane only once, while