Ear pain with several weeks of IV and oral antibiotics, usually fluoroquinolones. Acute otitis media is an infection of the middle ear. More than 80% of children experience at least one episode of otitis media by age 3 years. Acute otitis media is also most common in these first 3 years of life, though older children may also experience it. The most common causative bacteria are "Streptococcus pneumoniae", "Haemophilus influenzae", and "Moraxella catarrhalis". Otitis media often occurs with or following cold symptoms. The diagnosis is made by the combination of symptoms and examination of the tympanic membrane for redness, bulging, and/or a
Plasma membrane Ca2+ ATPase to involve the lymph nodes, and are more common among young women, which could help explain their worse prognosis compared with postmenopausal women. PMCAs were first discovered in the 1960s in the membranes of red blood cells. The presence of an ATPase was discovered in the membranes in 1961, and then in 1966 it was discovered that these ATPases pump Ca out of the cytosol. PMCA was first purified from red blood cell membranes in 1979. Plasma membrane Ca2+ ATPase The plasma membrane Ca ATPase (PMCA) is a transport protein in the plasma membrane of cells and functions to remove