Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
What Strong Fences Make entire script of the play available as a downloadable PDF on the website of Theater J. "What Strong Fences Make" is set at an IDF military checkpoint just outside Ramallah. Horovitz calls it "a simple and clear stage-play that attempts to make a statement about a real-life situation that is anything but simple and clear." The first reading was staged by New York's Barefoot Theater Company on April 15, 2009. The play was produced at the Boston Theater Marathon in 2009. What Strong Fences Make What Strong Fences Make is a 2009 play by Israel Horovitz. Horovitz told an interviewer