Endocrine system paracrine, and autocrine signaling have all been implicated in proliferation, one of the required steps of oncogenesis. Other common diseases that result from endocrine dysfunction include Addison's disease, Cushing's disease and Graves' disease. Cushing's disease and Addison's disease are pathologies involving the dysfunction of the adrenal gland. Dysfunction in the adrenal gland could be due to primary or secondary factors and can result in hypercortisolism or hypocortisolism . Cushing's disease is characterized by the hypersecretion of the adrenocorticotropic hormone (ACTH) due to a pituitary adenoma that ultimately causes endogenous hypercortisolism by stimulating the adrenal glands. Some clinical signs of Cushing's
Gastric glands lumen. Fundic gland polyposis is a medical syndrome where the fundus and the body of the stomach develops many polyps. Pernicious anemia is caused when damaged parietal cells fail to produce the intrinsic factor necessary for the absorption of vitamin B12. This can be one of the causes of vitamin B12 deficiency. Gastric glands The gastric glands are located in different regions of the stomach. These are the fundic glands, the cardiac glands, and the pyloric glands. The glands and gastric pits are located in the stomach lining. The glands themselves are in the lamina propria of the mucous membrane