Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
What Is Life the role of "entertainer" in his songwriting. In "I Me Mine", Harrison recalls that he changed his mind about offering "What Is Life" to Preston once he'd arrived at Olympic Studios and found the singer busy working on more typical material – or "playing his funky stuff" as Harrison puts it. Rather than attempt it with the Beatles during the band's concurrent "Abbey Road" sessions, he stockpiled the track with his many other unused songs from the period – "All Things Must Pass", "Let It Down", "I'd Have You Anytime" and "Run of the Mill" among them – and revisited