Antibiotic synergy with enterococcal endocarditis experienced a high relapse rate when penicillin G alone was used for treatment and a demonstrably lower relapse rate when streptomycin was combined with penicillin G to combat the infection. Since that time the research community has conducted numerous studies regarding the effects and possibilities of antibiotic combinations. Today, combination therapy is recognized as providing a broad spectrum of antibiotic coverage, effectively fighting polymicrobial infections, minimizing selection for antibiotic resistant strains, lowering dose toxicity where applicable, and in some cases providing synergistic activity. Antibiotic synergy is desirable in a clinic sense for several reasons. At the patient
Antibiotic properties of nanoparticles enhanced or induced with the addition of organic drugs. Gold particles, while not inherently antimicrobial, were discovered to express antimicrobial properties when functionalized with ampicillin. In addition to this, gold nanoparticles demonstrated improved membrane permeability with the addition of 4,6-diamino-2-pyrimidenthiol (DAPT) and non-antiobiotic amines (NAA) to their surfaces. Antibiotic properties of nanoparticles Nanoparticles have been studied extensively for their antimicrobial properties in order to fight super bug bacteria. Several characteristics in particular make nanoparticles strong candidates as a traditional antibiotic drug alternative. Firstly, they have a high surface area to volume ratio, which increases contact area with target organisms. Secondly,