Endocrine disruptor occur from low-dose exposure to exogenous hormones or hormonally active chemicals such as bisphenol A. These chemical can bind to receptors for other hormonally mediated processes. Furthermore, since endogenous hormones are already present in the body in biologically active concentrations, additional exposure to relatively small amounts of exogenous hormonally active substances can disrupt the proper functioning of the body's endocrine system. Thus, an endocrine disruptor can elicit adverse effects at much lower doses than a toxicity, acting through a different mechanism. The timing of exposure is also critical. Most critical stages of development occur in utero, where the fertilized egg
Endocrine surgery performed by surgeons who do at least 100 thyroid operations per year.In the United Kingdom most thyroid surgery is performed by surgeons doing less than 20 thyroid operations per year. This results in a high risk of permanent voice change (up to 2%) and a high risk of parathyroid damage. In expert hands these risks should be nearer 0.5%.Permanent damage to both voice box nerves is an extreme rarity and needs in most cases a permanent tracheotomy. Endocrine surgery Endocrine surgery is a surgical sub-speciality focusing on surgery of the endocrine glands, including the thyroid gland, the parathyroid glands, the