Parasympathetic nervous system act in a complementary way increasing or slowing the heart rate. In this context, the vagus nerve acts on sinoatrial node slowing its conduction thus actively modulating vagal tone accordingly. This modulation is mediated by the neurotransmitter acetylcholine and downstream changes to ionic currents and calcium of heart cells. The vagus nerve plays a crucial role in heart rate regulation by modulating the response of sinoatrial node, vagal tone can be quantified by investigating heart rate modulation induced by vagal tone changes. As a general consideration, increased vagal tone (and thus vagal action) is associated with a diminished and more
Sentinel node list, can be simplified remarkably using a sentinel node to demarcate the beginning and end of the list. Following is a Python implementation of a circular doubly-linked list: Notice how the codice_13 method takes the node that will be displaced by the new node in the parameter codice_14. For appending to the left, this is the head of a non-empty list, while for appending to right, it is the tail. But because of how the linkage is setup to refer back to the sentinel, the code just works for empty lists as well, where codice_14 will be the sentinel node.