Glycogen branching enzyme leads to increased osmotic pressure resulting in cellular swelling and death. The tissues most affected by this disease are the liver, heart, and neuromuscular system, areas with the greatest levels of glycogen accumulation. Abnormal glycogen buildup in the liver interferes with liver functioning and can result in an enlarged liver and liver disease. In muscles, the inability of cells to efficiently breakdown glycogen due to the severe reduction or absence of branching can lead to muscle weakness and atrophy. At least three mutations in the GBE1 gene have been found to cause another disease called adult polyglucosan body disease (APBD).
Organ donation in Australia regards to organ donation, which has a large impact on families giving consent for organ donation. Donation cannot go ahead without families consent even if the person is on the donor register. In most cases religions support organ donation. There are a few aspects of each religion that make the logistics of organ donation difficult however most of these can be overcome in some way. Most organ donations in predominately Muslim countries are live donations, for example in Iran in 2006 only 13% of renal transplants were from deceased donation. In Islamic religion, violating the human body whether living or