Β-lactam antibiotic reactions to any β-lactam antibiotic may occur in up to 10% of patients receiving that agent (a small fraction of which are truly IgE-mediated allergic reactions, see amoxicillin rash). Anaphylaxis will occur in approximately 0.01% of patients. There is perhaps a 5%-10% cross-sensitivity between penicillin-derivatives, cephalosporins, and carbapenems; but this figure has been challenged by various investigators. Nevertheless, the risk of cross-reactivity is sufficient to warrant the contraindication of all β-lactam antibiotics in patients with a history of severe allergic reactions (urticaria, anaphylaxis, interstitial nephritis) to any β-lactam antibiotic. A Jarisch–Herxheimer reaction may occur after initial treatment of a spirochetal
Antibiotic Action Antibiotic Action Antibiotic Action is a UK-based initiative that works to raise global awareness about antibiotic resistance, and is funded by the British Society for Antimicrobial Chemotherapy (BSAC), a UK registered charity. Antibiotic Action seeks to inform and educate people from various backgrounds, ranging from politicians to healthcare professionals to the public, about the need for discovery, research, and development of new treatments for bacterial infections to combat antibiotic resistance. It also aims to strengthen and enhance academic-industrial partnerships by bringing together communities that need antibiotics with academia, health-care professionals, and pharmaceutical companies to address the challenges facing antibiotic research,