Pacemaker current on hyperpolarization, and very slow kinetics. The funny current is highly expressed in spontaneously active cardiac regions, such as the sinoatrial node (SAN, the natural pacemaker region), the atrioventricular node (AVN) and the Purkinje fibres of conduction tissue. The funny current is a mixed sodium–potassium current that activates upon hyperpolarization at voltages in the diastolic range (normally from −60/−70 mV to −40 mV). When, at the end of a sinoatrial action potential, the membrane repolarizes below the I threshold (about −40/−50 mV), the funny current is activated and supplies inward current, which is responsible for starting the diastolic depolarization phase
Sinoatrial node slowly). These channels allow a flow of calcium ions (Ca) into the cell, making the membrane potential more positive. Phase 0 This is the depolarisation phase. When the membrane potential reaches a threshold value (around -20 to -50 mV), it begins to rapidly depolarise (become more positive). This is mainly due to the flow of Ca through the L-type calcium channels, which are now fully open. During this stage the T-type calcium channels and HCN channels deactivate. Phase 3 This phase is the repolarisation phase. This occurs due to the inactivation of the L-type calcium channels (preventing the movement of