Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
Achilles tendon rupture to rupture. The use of quinolone antibiotics can cause several forms of tendinitis and tendon rupture, including rupture of the Achilles tendon. The risk is higher in people who are older than 60, who are also taking corticosteroids, or have kidney disease; it also increases with dose and taking them for longer periods of time. As of 2016 the mechanism through which quinolones cause this, was unclear. The Achilles tendon is the strongest and thickest tendon in the body, connecting the gastrocnemius, soleus and plantaris to the calcaneus. It is approximately 15 centimeters (5.9 inches) long and begins near the