Tendon and degeneration or weakening of the tendons, which may eventually lead to tendon rupture. Tendinopathies can be caused by a number of factors relating to the tendon extracellular matrix (ECM), and their classification has been difficult because their symptoms and histopathology often are similar. The first category of tendinopathy is paratenonitis, which refers to inflammation of the paratenon, or paratendinous sheet located between the tendon and its sheath. Tendinosis refers to non-inflammatory injury to the tendon at the cellular level. The degradation is caused by damage to collagen, cells, and the vascular components of the tendon, and is known to
Patellar tendon rupture weakness after the injury and repair. If the tendon rupture is a partial tear (without the two parts of the tendon being separated) then non-surgical methods of treatment may suffice. The future of non-surgical care for partial patella tendon ruptures is likely bioengineering. Ligament reconstruction is possible using mesenchymal stem cells and a silk scaffold. These same stem cells have been shown to be capable of seeding repair of damaged animal tendons. In 2010, a clinical study proved that mechanical loading of the tendon callus during the remodelling phase leads to healing by regeneration. Patellar tendon rupture Patellar tendon rupture