Willow active extract of the bark, called salicin, was isolated to its crystalline form in 1828 by Henri Leroux, a French pharmacist, and Raffaele Piria, an Italian chemist, who then succeeded in separating out the compound in its pure state. In 1897, Felix Hoffmann created a synthetically altered version of salicin (in his case derived from the "Spiraea" plant), which caused less digestive upset than pure salicylic acid. The new drug, formally acetylsalicylic acid, was named Aspirin by Hoffmann's employer Bayer AG. This gave rise to the hugely important class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). Some of humans'
U Should've Known Better Me" was shelved, the song was one out of five original records that were transferred into its new version, "After the Storm". Although a duet with DMX, "Don't Gotta Go Home", was expected be released as the album's fourth single at times, "U Should've Known Better" eventually replaced original plans. Released as the album's fourth and final single in March 2004, "U Should've Known Better" opened as the Hot Shot Debut of the week at number 72 on "Billboard"s Hot R&B/Hip-Hop Singles & Tracks chart in the week of April 3, 2004. However, it took another three months until the