The Primordial Emotions Denton distinguishes between primordial emotions, "imperious states of arousal and compelling intentions to act" (p. 7) driven by activation of interoceptors and involving ancient, lower brain regions such as the medulla, midbrain and hypothalamus, and "classic" emotions, such as anger, fear and love, driven by distance receptors (vision, hearing, olfaction) and mediated by higher, more recently evolved brain regions. The Primordial Emotions The Primordial Emotions: The Dawning of Consciousness is a 2006 book by the Australian neuroscientist Derek Denton. Denton argues that, if self-awareness and intentionality are intrinsic to consciousness, the primordial emotions such as thirst, hunger and pain (that
Lateral hypothalamus neuropeptides orexin-A and orexin-B are the primary signaling neurochemicals in orexin neurons; pathway-specific neurochemicals include GABA, melanin-concentrating hormone, nociceptin, glucose, the dynorphin peptides, and the appetite-regulating peptide hormones leptin and ghrelin, among others. Notably, cannabinoid receptor 1 (CB1) is colocalized on orexinergic projection neurons in the lateral hypothalamus and many output structures, where the CB1 and orexin receptor 1 (OX1) receptors form the CB1–OX1 receptor heterodimer. The orexinergic projections from the lateral hypothalamus innervate the entirety of the remainder of the hypothalamus, with robust projections to the posterior hypothalamus, tuberomammillary nucleus (the histamine projection nucleus), the arcuate nucleus, and the