Anatomy of the cerebellum to the cerebellum, in two categories consisting of mossy and climbing fibers, respectively. Mossy fibers can originate from the pontine nuclei, which are clusters of neurons located in the pons that carry information from the contralateral cerebral cortex. They may also arise within the spinocerebellar tract whose origin is located in the ipsilateral spinal cord. Most of the output from the cerebellum initially synapses onto the deep cerebellar nuclei before exiting via the three peduncles. The most notable exception is the direct inhibition of the vestibular nuclei by Purkinje cells. During the early stages of embryonic development, the brain starts
Antigen transfer in the thymus in thymic medulla, namely clonal deletion ("recessive tolerance") and T Regulatory cells selection ("dominant tolerance") which force autoreactive T cells to apoptosis or skew them into suppressor T regulatory cells (TRegs), respectively, in order to protect body against manifestations of autoimmunity. These processes are mediated especially by unique subset of stromal cells called Medullary thymic epithelial cells (mTECs) via presentation of Tissue restricted antigens (TRAs) that represent self tissues from almost all parts of the body. mTECs are not only capable to present TRAs as efficient APCs. They are also potent in production of these TRAs via unique process called