Tympanic membrane retraction adherent to other structures within the middle ear. Some retractions continue to progress and grow more deeply into the ear. This can result in erosion of bone. As the middle ear is only a narrow space, the eardrum only has to retract a short distance before it touches boney structures within the middle ear such as the ossicles. It may become adherent to these bones and in some cases, this contact leads to erosion of the bone. As well as ossicular erosion, the bone of the ear canal (e.g. the scutum) and even bone over the cochlea (the promontory) can
Translocase of the inner membrane modified complex containing Tim12, on the outer surface of the TIM22 complex. Tim12 is membrane bound and thus may act as a linker molecule docking Tim9 and Tim10 to the face of the TIM22 complex. The carrier preprotein is then inserted into the inner mitochondrial membrane in a potential-dependent fashion. The membrane potential is necessary for both insertion of the precursor into the carrier translocase and lateral release of the protein into the lipid phase of the inner mitochondrial membrane, which completes protein translocation. However this membrane potential-dependent process takes place in absence of ATP-driven machinery. TIM17A; TIMM17A; TIMM17B; TIMM22;