Antibiotic resistance in gonorrhea mechanism for beta-lactam resistance. There have been over 200 beta-lactamases described and some of them are antibiotic specific. TEM-1 is a penicillinase specific for penicillins. This enzyme will bind to the beta-lactam ring which is a structural characteristic for beta-lactams and hydrolyze the ring. This renders the antibiotic inactive. The spread of the penicillinase resistance was much faster compared to the chromosomal-mediated resistance mechanisms. The plasmids containing TEM-1 could be passed from bacterium to bacterium via conjugation Quinolones are a class of synthetic antibiotics that inhibit DNA replication, recombination, and repair by interacting with the bacterial DNA gyrase and/or topoisomerase
Antibiotic prophylaxis 2006 against antibiotics for growth promotion purposes. It was estimated in 2014 that over 80% of the world's antibiotic use was on farms. Coccidiosis in fowl had evolved increased tolerance to the antibiotic feed. The WHO warned in April 2014 that farm use was a contributor to superbugs in humans. The Auditor General of Canada found lack of progress in 2014 on antimicrobial resistance despite three years of government funds that should have been used to implement a reduction programme. A CBC writer was concerned that there was in Canada "no coordinated national system to control antibiotics in agriculture." Due