Urinary bladder collects in the bladder, fed from the two ureters that connect the bladder with the kidneys. Urine leaves the bladder via the urethra, a single muscular tube ending in an opening – the urinary meatus, where it exits the body. Anatomists divide the bladder into:. The apex (prev."vertex") is directed forward toward the upper part of the pubic symphysis, and from there the median umbilical ligament continues upward on the back of the anterior abdominal wall to the umbilicus. The peritoneum is carried by it from the apex on to the abdominal wall to form the middle umbilical fold. The
Bladder cancer to facilitate the absorption and action of a chemotherapy drug instilled directly into the bladder. Another technology - electromotive drug administration (EMDA) – uses an electric current to enhance drug absorption after surgical removal of the tumor. Another technology, thermotherapy, uses radio-frequency energy to directly heat the bladder wall, which together with chemotherapy shows a synergistic effect, enhancing each other's capacity to kill tumor cells. This technology has been studied by a number of different investigators. Untreated, superficial tumors may gradually begin to infiltrate the muscular wall of the bladder. Tumors that infiltrate the bladder wall require more radical surgery,