Menstrual cycle mating partners during the menstrual cycle; however, those seeking a short-term relationship were more likely to choose a partner with more masculine features than usual. This was found to be the case especially during the woman's high conception risk stage and when salivary testosterone was high. However, when women are in the luteal (non-fertile) phase, they tend to prefer men (and females) with more feminine faces. A preference is also shown for self-resembling faces and apparent health in faces during the luteal phase of the cycle. Apparent health preferences were found to be strongest when progesterone levels were high. Additionally,
Selective progesterone receptor modulator Selective progesterone receptor modulator A selective progesterone receptor modulator (SPRM) is an agent that acts on the progesterone receptor (PR), the biological target of progestogens like progesterone. A characteristic that distinguishes such substances from full receptor agonists (e.g., progesterone, progestins) and full antagonists (e.g., aglepristone) is that their action differs in different tissues, i.e. agonist in some tissues while antagonist in others. This mixed profile of action leads to stimulation or inhibition in tissue-specific manner, which further raises the possibility of dissociating undesirable adverse effects from the development of synthetic PR-modulator drug candidates. Ever since the discovery of the progesterone