Allergic inflammation immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema. The late phase of a Type 1 reaction (which develops 8–12
Fabio Cannavaro during periods of anoxia and stress. It is not on the banned substance list. This chemical is, in partnership with adenosine triphosphate (ATP), fundamental to the ability of the body to produce muscular energy. Phosphocreatine is formed naturally within the body, with over 95% of the compound stored within the muscle cells. The body also receives dietary creatine primarily through the consumption of meat. No action was ever taken regarding this incident. On 8 October 2009, Cannavaro failed a drug test. However, Juventus claimed the drugs were medicine for a severe allergic reaction to a wasp sting, and not performance-enhancing.