Allergic inflammation immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema. The late phase of a Type 1 reaction (which develops 8–12
The Power that Preserves had to act through a proxy, Covenant, and even after causing Covenant to be transported to the Land, the Creator did not interfere with Covenant's freedom of will in any way. The decision to "save or damn" the Land was Covenant's own. The Creator then tells Covenant that he has a choice: either he can remain in the Land in full health, or he can be returned to life in his own world, where he otherwise would have died from an allergic reaction to the anti-venom treatment applied to his unconscious body. Covenant, still unwilling to fully accept the Land,