Acetyl group known as paracetamol), and acetylsalicylic acid (better known as aspirin). The introduction of an acetyl group into a molecule is called acetylation. In biological organisms, acetyl groups are commonly transferred from acetyl-CoA to other organic molecules. Acetyl-CoA is an intermediate both in the biological synthesis and in the breakdown of many organic molecules. Acetyl-CoA is also created during the second stage of cellular respiration, the Krebs Cycle, by the action of pyruvate dehydrogenase on pyruvic acid. Histones and other proteins are often modified by acetylation. For example, on the DNA level, histone acetylation by acetyltransferases (HATs) causes an expansion of
U Should've Known Better Me" was shelved, the song was one out of five original records that were transferred into its new version, "After the Storm". Although a duet with DMX, "Don't Gotta Go Home", was expected be released as the album's fourth single at times, "U Should've Known Better" eventually replaced original plans. Released as the album's fourth and final single in March 2004, "U Should've Known Better" opened as the Hot Shot Debut of the week at number 72 on "Billboard"s Hot R&B/Hip-Hop Singles & Tracks chart in the week of April 3, 2004. However, it took another three months until the