Pacemaker current on hyperpolarization, and very slow kinetics. The funny current is highly expressed in spontaneously active cardiac regions, such as the sinoatrial node (SAN, the natural pacemaker region), the atrioventricular node (AVN) and the Purkinje fibres of conduction tissue. The funny current is a mixed sodium–potassium current that activates upon hyperpolarization at voltages in the diastolic range (normally from −60/−70 mV to −40 mV). When, at the end of a sinoatrial action potential, the membrane repolarizes below the I threshold (about −40/−50 mV), the funny current is activated and supplies inward current, which is responsible for starting the diastolic depolarization phase
Node influence metric probabilities. The accessibility has been shown to reveal community structure in urban networks, corresponds to the number of nodes which can be visited in a defined time period, and is predictive of the outcome of epidemiological SIR model spreading processes on networks with large diameter and low density. The expected force measures node influence from an epidemiological perspective. It is the expected value of the force of infection generated by the node after two transmissions. The expected force of a node formula_4 is given by where the sum is taken over the set formula_9 of all possible transmission clusters resulting