Scar healing which heals with a scar. The myofibroblasts make up a high proportion of the fibroblasts proliferating in the postembryonic wound at the onset of healing. In the rat model, for instance, myofibroblasts can constitute up to 70% of the fibroblasts, and is responsible for fibrosis on tissue. Generally, the myofibroblasts disappear from the wound within 30 days, but can stay around in pathological cases in hypertrophy, such as keloids. Myofibroblasts have plasticity and in mice can be transformed into fat cells, instead of scar tissue, via the regeneration of hair follicles. Early and effective treatment of acne scarring can
Circumcision scar in a fine, even scar. Circumcisions after the newborn period that are performed without sutures (techniques that use cyanoacrylate tissue adhesive instead of sutures and techniques like Plastibell that heal by secondary intention) often result in an even, circumferential scar. There is some controversy as to what happens to the severed nerves of the foreskin at the scar. Xin "et al". (1997) suggest that nerves regenerate, forming new receptors. However, pathologists Cold & Taylor (1999) report: "Histology of the male circumcision scar shows amputation neuromas, Schwann cell proliferation and the bulbous collection of variably sized neurites. Amputation neuromas do not