Sinoatrial nodal artery variant in approximately 10% of human hearts. This artery is larger than normal and supplies a good part of the left atrium, but also right sided structures like part of the sinoatrial node and the atrioventricular nodal areas. In this variant, the artery courses in the sulcus between the left superior pulmonary vein and the left atrial appendage where it could be susceptible to injury during catheter or surgical ablation procedures on the left atrium, especially for atrial fibrillation ablation or open heart cardiac surgery. Sinoatrial nodal artery The sinoatrial nodal artery (or sinuatrial nodal artery or sinoatrial artery) is
Sinoatrial node (in particular T1-T4). These nerves release a neurotransmitter called noradrenaline (NA). This binds to a receptor on the SA node membrane, called a beta-1adrenoceptor. Binding of NA to this receptor activates a G-protein (in particular a G-Protein, S for stimulatory) which initiates a series of reactions (known as the cAMP pathway) that results in the production of a molecule called cyclic adenosinemonophosphate (cAMP). This cAMP binds to the HCN channel (see above). Binding of cAMP to the HCN, increases the flow of Na and K into the cell, speeding up the pacemaker potential, so producing action potentials at a quicker