History of diabetes further clarified in 1921, when Sir Frederick Grant Banting and Charles Herbert Best repeated the work of Von Mering and Minkowski, and went further to demonstrate they could reverse induced diabetes in dogs by giving them an extract from the pancreatic islets of Langerhans of healthy dogs. The islets of Langerhans was discovered in 1869 by an anatomist named Paul Langerhans. He identified the keys cells in the pancreas which produce the main substance that controls glucose levels in the body. Banting, Best, and colleagues (especially the chemist Collip) went on to purify the hormone insulin from bovine pancreases at
Ryan Langerhans of the independent Atlantic League. Langerhans was signed to a minor league contract and assigned to the Buffalo Bisons again on August 22, 2013. When the Bisons season ended, Langerhans asked for and received his release, and returned to the Sugar Land Skeeters for their playoff run. On September 26, Langerhans again signed with the Blue Jays. This time a major league contract as the Blue Jays were short on position players. He became a free agent on October 8, 2013. He hit a game-winning home run against J.P. Howell on August 7, 2009, with two outs in the bottom