Nav1.5 kb. The gene consists of 28 exons, of which exon 1 and in part exon 2 form the 5’ untranslated region (5’UTR) and exon 28 the 3’ untranslated region (3’UTR) of the RNA. SCN5A is part of a family of 10 genes that encode different types of sodium channels, i.e. brain-type (Na1.1, Na1.2, Na1.3, Na1.6), neuronal channels (Na1.7, Na1.8 and Na1.9), skeletal muscle channels (Na1.4) and the cardiac sodium channel Na1.5. SCN5A is mainly expressed in the heart, where expression is abundant in working myocardium and conduction tissue. In contrast, expression is low in the sinoatrial node and atrioventricular node.
Orbital node Orbital node An orbital node is either of the two points where an orbit intersects a plane of reference to which it is inclined. A non-inclined orbit, which is contained in the reference plane, has no nodes. Common planes of reference include the following: If a reference direction from one side of the plane of reference to the other is defined, the two nodes can be distinguished. For geocentric and heliocentric orbits, the ascending node (or north node) is where the orbiting object moves north through the plane of reference, and the descending node (or south node) is where it