20th century in science biologically relevant molecules, they were, till the end of the 20th century, more a collection of rules, observations, and recipes than rigorous ab initio quantitative methods. This heuristic approach triumphed in 1953 when James Watson and Francis Crick deduced the double helical structure of DNA by constructing models constrained by and informed by the knowledge of the chemistry of the constituent parts and the X-ray diffraction patterns obtained by Rosalind Franklin. This discovery lead to an explosion of research into the biochemistry of life. In the same year, the Miller–Urey experiment demonstrated that basic constituents of protein, simple amino acids,
Francis Crick of the importance of her experimental results in Watson and Crick's model building and theoretical analysis, Franklin should have had her name on the original Watson and Crick paper in "Nature". Franklin and Gosling submitted their own joint 'second' paper to "Nature" at the same time as Wilkins, Stokes, and Wilson submitted theirs (i.e. the 'third' paper on DNA). Watson's portrayal of Franklin in "The Double Helix" (written after Franklin's death when libel laws did not apply anymore) was negative and gave the appearance that she was Wilkins' assistant and was unable to interpret her own DNA data. The X-ray