Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
Tendon transfer used to restore a single function. Transfer of one tendon to restore multiple functions will compromise strength and movement. These are examples of commonly performed tendon transfers. Many of the lower extremity tendon transfers were performed during the nineteenth century to improve ambulation in polio patients due to post-poliomyelitis paralysis. In the beginning o twentieth century, tendon transfers were used to correct congenital talipes equina. Tendon transfers were extensively performed during World Wars I and II to patients with upper extremity injuries. Tendon transfer A tendon transfer is a surgical process in which the insertion of a tendon is moved,