Apparent mineralocorticoid excess syndrome cases recorded worldwide. Liquorice consumption may also cause a temporary form of AME due to its ability to block 11β-hydroxysteroid dehydrogenase type 2, in turn causing increased levels of cortisol. Cessation of licorice consumption will reverse this form of AME. Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In
Water organ air is pushed into the reservoir with hand pumps, and exits the reservoir as pressurized air to blow through the pipes. The reservoir is open on the bottom, allowing water to maintain the pressure on the air as the air supply fluctuates from either the pumps pushing more air in, or the pipes letting air out. On the water organ, since the 15th century, the water is also used as a source of power to drive a mechanism similar to that of the barrel organ, which has a pinned barrel that contains a specific song to be played. The hydraulis