Allergic inflammation immediate allergic reaction or as a Type I allergic reaction. The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following the cross-linking of allergen specific IgE molecules bound to mast cell FcεRI receptors. These mediators affect nerve cells causing itching, smooth muscle cells causing contraction (leading to the airway narrowing seen in allergic asthma), goblet cells causing mucus production, and endothelial cells causing vasodilatation and edema. The late phase of a Type 1 reaction (which develops 8–12
Eucharist in the Catholic Church softness and the other appearances, but is distinct from them. Whereas the appearances, which are referred to by the philosophical term "accidents" are perceptible to the senses, the substance is not. When at his Last Supper Jesus said: "This is my body", what he held in his hands had all the appearances of bread. However, the Catholic Church teaches that the underlying reality was changed in accordance with what Jesus said, that the "substance" of the bread was converted to that of his body. In other words, it "actually was" his body, while all the appearances open to the senses