History of aspirin mid-eighteenth century. By the nineteenth century pharmacists were experimenting with and prescribing a variety of chemicals related to salicylic acid, the active component of willow extract. In 1853, chemist Charles Frédéric Gerhardt treated acetyl chloride with sodium salicylate to produce acetylsalicylic acid for the first time; in the second half of the nineteenth century, other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis. In 1897, scientists at the drug and dye firm Bayer began investigating acetylsalicylic acid as a less-irritating replacement for standard common salicylate medicines, and identified a new way to synthesize it.
U Should've Known Better song entered the "Billboard" Hot 100 chart, where it debuted at number 67 in the week of June 6, 2004, the second-highest debut of the week. "U Should've Known Better" remained twenty weeks on the chart, reaching its peak position of number 19 in its ninth week. It marked the second single from "After the Storm" to reach the top twenty on the Hot 100chart and, as the album's final single, would remain its second highest-charting offering behind leading single "So Gone." Although never released on a CD single or CD maxi single format, "U Should've Known Better" was also