Maurice Wilkins by James Watson. During the second phase, 1951–52, Wilkins produced clear "B form" "X" shaped images from squid sperm, images he sent to James Watson and Francis Crick, causing Watson to write "Wilkins... has obtained extremely excellent X-ray diffraction photographs" [of DNA]. In 1953 Wilkins' colleague Rosalind Franklin instructed Raymond Gosling to hand over to Wilkins a high quality image of "B" form DNA ("Photo 51"), which she had made in 1952 but had “put it aside” as she was leaving King's College London. Wilkins showed it to Watson. This image, along with the knowledge that Linus Pauling had proposed
Molecular models of DNA is carried by spool-like proteins named histones, around which DNA winds. It is the further compaction of this DNA-protein complex which produces the well known mitotic eukaryotic chromosomes. In the late 1970s, alternate non-helical models of DNA structure were briefly considered as a potential solution to problems in DNA replication in plasmids and chromatin. However, the models were set aside in favor of the double-helical model due to subsequent experimental advances such as X-ray crystallography of DNA duplexes, and later the nucleosome core particle, and the discovery of topoisomerases. Such non-double-helical models are not currently accepted by the mainstream scientific