History of genetics code for specific proteins, leading to the "one gene, one enzyme" hypothesis. Oswald Avery, Colin Munro MacLeod, and Maclyn McCarty showed in 1944 that DNA holds the gene's information. In 1952, Rosalind Franklin and Raymond Gosling produced a strikingly clear x-ray diffraction pattern indicating a helical form, and in 1953, James D. Watson and Francis Crick demonstrated the molecular structure of DNA. Together, these discoveries established the central dogma of molecular biology, which states that proteins are translated from RNA which is transcribed by DNA. This dogma has since been shown to have exceptions, such as reverse transcription in retroviruses.
Rudolf Signer from the Thymus of calves, of which he took 15 grams of extraordinarily pure DNA to London. In England he gave it to various scientists, among them Maurice Wilkins, in order to promote research in the field. The analysis of X ray images of these DNA samples in Wilkins' laboratory allowed James Watson and Francis Crick to discover the double-helix structure of DNA. Rests of the DNA which Signer brought to England, survive today in the collection of King's College, London. Over 250 of Signer's scientific writings were published during his lifetime. The Lavoisier Medal was awarded to him for