Antibiotic synergy with enterococcal endocarditis experienced a high relapse rate when penicillin G alone was used for treatment and a demonstrably lower relapse rate when streptomycin was combined with penicillin G to combat the infection. Since that time the research community has conducted numerous studies regarding the effects and possibilities of antibiotic combinations. Today, combination therapy is recognized as providing a broad spectrum of antibiotic coverage, effectively fighting polymicrobial infections, minimizing selection for antibiotic resistant strains, lowering dose toxicity where applicable, and in some cases providing synergistic activity. Antibiotic synergy is desirable in a clinic sense for several reasons. At the patient
Discovered attack bishop gets out of the way of White's queen) against Black's queen with check. Black must get out of check, then White can follow up with 10.Qxd4. Discovered attack In chess, a discovered attack is an attack revealed when one piece moves out of the way of another. Discovered attacks can be extremely powerful, as the piece moved can make a threat independently of the piece it reveals. Like many chess tactics, they succeed because the opponent is unable to meet two threats at once. While typically the consequence of a discovered attack is the gain of , they do