Pure red cell aplasia to respond to treatments with rituximab and tacrolimus. Pure red cell aplasia Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of anemia affecting the precursors to red blood cells but not to white blood cells. In PRCA, the bone marrow ceases to produce red blood cells. There are multiple etiologies that can cause PRCA. The condition has been first described by Paul Kaznelson in 1922. Signs and symptoms may include: Causes of PRCA include: PRCA is considered an autoimmune disease as it will respond to immunosuppressant treatment such as cyclosporin in many patients, though this approach is
Hematopoietic stem cell Hematopoietic stem cell Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. This process is called haematopoiesis.<ref name="Birbrair n/a–n/a"></ref> This process occurs in the red bone marrow, in the core of most bones. In embryonic development, the red bone marrow is derived from the layer of the embryo called the mesoderm. Hematopoiesis is the process by which all mature blood cells are produced. It must balance enormous production needs (the average person produces more than 500 billion blood cells every day) with the need to precisely regulate the number of each blood cell type