Sesamoid bone Sesamoid bone In anatomy, a sesamoid bone () is a bone embedded within a tendon or a muscle. It is derived from the Latin word ("sesame seed"), due to the small size of most sesamoids. Often, these bones form in response to strain, or can be present as a normal variant. The kneecap is the largest sesamoid bone in the body. Sesamoids act like pulleys, providing a smooth surface for tendons to slide over, increasing the tendon's ability to transmit muscular forces. The sesamoid is a small nodular bone most often present embedded in tendons in the region of the
Muscle network which could show a large degree of divergence in the formation of muscle cells. Through this analysis, it seems that the myogenic GRN is an ancestral GRN with actual changes in myogenic function and structure possibly being linked to later coopts of genes at different times and places. Evolutionarily, specialized forms of skeletal and cardiac muscles predated the divergence of the vertebrate/arthropod evolutionary line. This indicates that these types of muscle developed in a common ancestor sometime before 700 million years ago (mya). Vertebrate smooth muscle was found to have evolved independently from the skeletal and cardiac muscle types.