Apparent mineralocorticoid excess syndrome cases recorded worldwide. Liquorice consumption may also cause a temporary form of AME due to its ability to block 11β-hydroxysteroid dehydrogenase type 2, in turn causing increased levels of cortisol. Cessation of licorice consumption will reverse this form of AME. Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In
Water organ Alexandria (c. 62 AD). Like the water clocks (clepsydra) of Plato's time, they were not regarded as playthings but might have had a particular significance in Greek philosophy, which made use of models and simulacra of this type. Hydraulically blown organ pipes were used to imitate birdsong, and musicologists Susi Jeans and Arthur W.J.G. Ord-Hume have suggested that it was used to create the sounds of the Vocal Memnon. For the latter, solar heat was used to syphon water from one closed tank into another, thereby producing compressed air for sounding the pipes. Characteristics of the hydraulis have been inferred