Artificial hair integrations is a type of synthetic fiber that can withstand heat up to 400 °F (200 °C), and can actually outlast human hair. It is very similar to human hair given it is tangle-free and has a natural sheen. It can be straightened or curled, however, it takes longer to set and futura cannot be colored. It is sometimes sold as a human hair blend. The human hair shaft is made up of dead, hard protein, called keratin, in three layers. The inner layer is called the medulla and may not be present. The next layer is the cortex and the
Microphthalmia-associated transcription factor MITF protein. The new MITF protein is unable to bind to DNA and melanocyte development and subsequently melanin production is altered. A reduced number of melanocytes can lead to hearing loss, and decreased melanin production can account for the light skin and hair color that make Tietz syndrome so noticeable. Melanocytes are commonly known as cells that are responsible for producing the pigment melanin which gives coloration to the hair, skin, and nails. The exact mechanisms of how exactly melanocytes become cancerous are relatively unclear, but there is ongoing research to gain more information about the process. For example, it