Recreational drug use are caused by an excessive response of the body to allergens, such as the pollen released by grasses and trees. An allergic reaction causes release of histamine by the body. Other uses of antihistamines are to help with normal symptoms of insect stings even if there is no allergic reaction. Their recreational appeal exists mainly due to their anticholinergic properties, that induce anxiolysis and, in some cases such as diphenhydramine, chlorpheniramine, and orphenadrine, a characteristic euphoria at moderate doses. High dosages taken to induce recreational drug effects may lead to overdoses. Antihistamines are also consumed in combination with alcohol, particularly
Substance over form as reflecting only actual sales in "substance" (that is, items delivered to outside parties for payment), and not events that merely fit the "form" of sales documentation for convenience or expedience. The principle strictly governs and resolves disputes of whether workers are independent contractors or employees: Tax law forbids accounting for persons who are "substantially" employees in the "form" of independent contractors. The question of which "form" may be applied to any given case submits to objective tests of the "substance" of the work. Hence substance, over form, is the rule. Substance over form Substance over form is an accounting