Toxicodynamics into awareness by Our Stolen Future by Theo Colborn. Endocrine disrupting chemicals are known to accumulate in body tissue and are highly persistent in the environment. Many toxicants are known EDCs including pesticides, phthalates, phytoestrogens, some industrial/commercial products, and pharmaceuticals. These chemicals are known to cause endocrine disruption via a few different mechanisms. While the mechanism associated with the thyroid hormone receptor is not well understood, two more established mechanisms involve the inhibition of the androgen receptor and activation of the estrogen receptor. Certain toxicants act as endocrine disruptors by interacting with the androgen receptor. DDE is one example of
Multiple endocrine neoplasia type 2b Multiple endocrine neoplasia type 2b Multiple endocrine neoplasia type 2B (also known as "MEN2B", "Mucosal neuromata with endocrine tumors", "Multiple endocrine neoplasia type 3", and "Wagenmann–Froboese syndrome") is a genetic disease that causes multiple tumors on the mouth, eyes, and endocrine glands. It is the most severe type of multiple endocrine neoplasia, differentiated by the presence of benign oral and submucosal tumors in addition to endocrine malignancies. It was first described by Wagenmann in 1922, and was first recognized as a syndrome in 1965-1966 by E.D. Williams and D.J. Pollock. MEN 2B typically manifests before a child is 10 years