Tympanic membrane retraction used to manage tympanic membrane retraction, with the aims of preventing or relieving hearing loss and cholesteatoma formation. As retraction pockets may remain stable or resolve spontaneously, it may be appropriate to observe them for a period of time before considering any active treatment. The Valsalva maneuver increases middle ear pressure and can push a retracted eardrum out of the middle ear if is not adherent to middle ear structures. Hearing may improve as a result, however it can be a painful maneuver. The benefits are typically only temporary. Middle ear pressure can also be increased by Politzerization and with
Translocase of the outer membrane TOMM22, TOMM40, TOM7, TOMM7 Translocase of the outer membrane The translocase of the outer membrane (TOM) is a complex of proteins found in the outer mitochondrial membrane of the mitochondria. It allows movement of proteins through this barrier and into the intermembrane space of the mitochondrion. Most of the proteins needed for mitochondrial function are encoded by the nucleus of the cell. The outer membrane of the mitochondrion is impermeable to large molecules greater than 5000 Daltons. The TOM works in conjunction with the translocase of the inner membrane (TIM) to translocate proteins into the mitochondrion. Many of the proteins