Glycogen of glucose-1-phosphate: In vivo, phosphorolysis proceeds in the direction of glycogen breakdown because the ratio of phosphate and glucose-1-phosphate is usually greater than 100. Glucose-1-phosphate is then converted to glucose 6-phosphate (G6P) by phosphoglucomutase. A special debranching enzyme is needed to remove the α(1-6) branches in branched glycogen and reshape the chain into a linear polymer. The G6P monomers produced have three possible fates: The most common disease in which glycogen metabolism becomes abnormal is diabetes, in which, because of abnormal amounts of insulin, liver glycogen can be abnormally accumulated or depleted. Restoration of normal glucose metabolism usually normalizes glycogen
Wanamaker Organ This level of dedication was maintained when corporate parentage shifted from the Wanamaker family to Carter Hawley Hale Stores followed by Woodward & Lothrop, The May Department Stores Company, Lord & Taylor, and finally to Macy's. The Wanamaker Organ was originally built by the Los Angeles Art Organ Company, successors to the Murray M. Harris Organ Co., for the 1904 St. Louis World's Fair. It was designed to be the largest organ in the world, an imitation of a full-size orchestra with particularly complete resources of full organ tone including mixtures. In addition to its console, the organ was originally