Tendon induce endothelial cell proliferation and migration, and VEGF mRNA has been shown to be expressed at the site of tendon injuries along with collagen I mRNA. Bone morphogenetic proteins (BMPs) are a subgroup of TGF-β superfamily that can induce bone and cartilage formation as well as tissue differentiation, and BMP-12 specifically has been shown to influence formation and differentiation of tendon tissue and to promote fibrogenesis. In animal models, extensive studies have been conducted to investigate the effects of mechanical strain in the form of activity level on tendon injury and healing. While stretching can disrupt healing during the initial
Achilles tendon the bone; the gap is filled up with areolar and adipose tissue. A bursa lies between the tendon and the upper part of the calcaneus. It is about long. Along the side of the muscle, and superficial to it, is the small saphenous vein. The sural nerve the outer border of the tendon about 10cm below where it attaches to the bone. The tendon is the thickest tendon in the human body. It can receive a load stress 3.9 times body weight during walking and 7.7 times body weight when running. The blood supply to the Achilles tendon is poor,