Sinoatrial node rate, and increasing heart rate. An increase in heart rate is known as positive chronotropy. The parasympathetic nerves supplying the SA node (in particular the Vagus nerves) originate in the brain. These nerves release a neurotransmitter called acetylcholine (ACh). ACh binds to a receptor called an M2 muscarinic receptor, located on the SA node membrane. Activation of this M2 receptor, then activates a protein called a G-protein (in particular G protein, i for inhibitory). Activation of this G-protein, blocks the cAMP pathway, reducing its effects, therefore inhibiting sympathetic activity and slowing action potential production. As well as this, the G-protein
Orbital node Orbital node An orbital node is either of the two points where an orbit intersects a plane of reference to which it is inclined. A non-inclined orbit, which is contained in the reference plane, has no nodes. Common planes of reference include the following: If a reference direction from one side of the plane of reference to the other is defined, the two nodes can be distinguished. For geocentric and heliocentric orbits, the ascending node (or north node) is where the orbiting object moves north through the plane of reference, and the descending node (or south node) is where it