Tendon induce endothelial cell proliferation and migration, and VEGF mRNA has been shown to be expressed at the site of tendon injuries along with collagen I mRNA. Bone morphogenetic proteins (BMPs) are a subgroup of TGF-β superfamily that can induce bone and cartilage formation as well as tissue differentiation, and BMP-12 specifically has been shown to influence formation and differentiation of tendon tissue and to promote fibrogenesis. In animal models, extensive studies have been conducted to investigate the effects of mechanical strain in the form of activity level on tendon injury and healing. While stretching can disrupt healing during the initial
What Is Life the role of "entertainer" in his songwriting. In "I Me Mine", Harrison recalls that he changed his mind about offering "What Is Life" to Preston once he'd arrived at Olympic Studios and found the singer busy working on more typical material – or "playing his funky stuff" as Harrison puts it. Rather than attempt it with the Beatles during the band's concurrent "Abbey Road" sessions, he stockpiled the track with his many other unused songs from the period – "All Things Must Pass", "Let It Down", "I'd Have You Anytime" and "Run of the Mill" among them – and revisited