Apparent mineralocorticoid excess syndrome cases recorded worldwide. Liquorice consumption may also cause a temporary form of AME due to its ability to block 11β-hydroxysteroid dehydrogenase type 2, in turn causing increased levels of cortisol. Cessation of licorice consumption will reverse this form of AME. Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In
Water organ power the restored six-stop instrument. Among Renaissance writers on the water organ, Salomon de Caus was particularly informative. His book of 1615 includes a short treatise on making water organs, advice on tuning and registration, and many fine engravings showing the instruments, their mechanisms and scenes in which they were used. It also includes an example of suitable music for water organ, the madrigal Chi farà fed' al cielo by Alessandro Striggio, arranged by Peter Philips. Water organs were described in the numerous writings of the famous Ctesibius (3rd century BC), Philo of Byzantium (3rd century BC) and Hero of