Molecular models of DNA simulations that are very important to understand how DNA functions "in vivo". From the very early stages of structural studies of DNA by X-ray diffraction and biochemical means, molecular models such as the Watson-Crick nucleic acid double helix model were successfully employed to solve the 'puzzle' of DNA structure, and also find how the latter relates to its key functions in living cells. The first high quality X-ray diffraction patterns of A-DNA were reported by Rosalind Franklin and Raymond Gosling in 1953. Rosalind Franklin made the critical observation that DNA exists in two distinct forms, A and B, and produced
Raymond Gosling of x-ray diffraction photography of DNA and obtained at the time the sharpest diffraction images of DNA. Gosling made the X-ray diffraction image of DNA known as "Photograph 51". This work led directly to the 1962 Nobel Prize for Physiology or Medicine being awarded to Francis Crick, James D. Watson and Maurice Wilkins. Gosling was the co-author with Franklin of one of the three DNA double helix papers published in "Nature" in April 1953. His other King's colleagues included Alex Stokes and Herbert Wilson. Gosling briefly remained at King's College following the completion of his thesis in 1954 before lecturing