Lateral hypothalamus an OX1-induced CB1 pressor response in the rostral ventrolateral medulla. Narcolepsy is associated with a marked reduction in the number of orexinergic projection neurons from the lateral hypothalamus and very low orexin peptides in cerebrospinal fluid. This has been identified as the mechanism responsible for narcoleptic symptoms. Evidence suggest that OX1 neurons that synapse onto the dorsal nucleus of the vagus nerve and parts of the brain stem may play a role in the pathophysiology of chronic pain and visceral hypersensitivity in functional gastrointestinal disorders. Lateral hypothalamus The lateral hypothalamus, also called the lateral hypothalamic area, contains the primary orexinergic
Anatomy of the cerebellum pathway transmits signals that inform the cerebellum about the movement in progress and the upcoming movement. This helps the continuous adjustment of motor activity. The initiation of the movement is relayed to cerebellum via the corticoreticulocerebellar pathway. Those synapse ipsilaterally in the reticular formation, then via the inferior and middle peduncles into the cerebellar vermis. The motor cortex and somatosensory cortex projects onto the ipsilateral inferior and accessory olivary nuclei, then forming the olivocerebellar tract. Cortico-olivary fibers synapse bilaterally in the inferior olivary nucleus. The order is preserved in the olivocerebellar tract projections onto the ‘body maps’ in the contralateral