Progesterone and is responsible for approximately 70% of cytochrome P450-mediated progesterone metabolism. Other routes include 6α-, 16α-, and 16β-hydroxylation. However, treatment of women with ketoconazole, a strong CYP3A4 inhibitor, had minimal effects on progesterone levels, producing only a slight and non-significant increase, and this suggests that cytochrome P450 enzymes play only a small role in progesterone metabolism. In women, progesterone levels are relatively low during the preovulatory phase of the menstrual cycle, rise after ovulation, and are elevated during the luteal phase, as shown in diagram below. Progesterone levels tend to be less than 2 ng/mL prior to ovulation, and greater
Menstrual cycle of the menstrual cycle, regardless of fertility. Behavior towards potential mating partners changes during different phases of the menstrual cycle. Near ovulation, women may have increased physical attraction and interest in attending social gatherings with men. During the fertile phase of the cycle, women appear to prefer males who are more masculine. The intensity of mate guarding differs across the phases of the cycle, with increased mate guarding occurring when woman are fertile. During the fertile phase, many women experience more attraction, fantasies and sexual interest for extra pair men but not for the primary partner. They also engage in