Human skin color effects of tanning. Around the same age, women experience darkening of some areas of their skin. Human skin color fades with age. Humans over the age of thirty experience a decrease in melanin-producing cells by about 10% to 20% per decade as melanocyte stem cells gradually die. The skin of face and hands has about twice the amount of pigment cells as unexposed areas of the body, as chronic exposure to the sun continues to stimulate melanocytes. The blotchy appearance of skin color in the face and hands of older people is due to the uneven distribution of pigment cells
White (horse) as described below, can act to produce off-white phenotypes. Horses with strongly diluted coat colors usually have pale blue eyes, cream-colored coats, and rosy-pink skin. White markings are usually visible upon closer inspection. Although white horses are sometimes called "albino" there are no reported cases of a true "albino" horse. There are also references in literature calling white horses "albino". Dominant white in horses is caused by the absence of pigment cells (melanocytes), whereas albino animals have a normal distribution of melanocytes. In other animals, patches of unpigmented skin, hair, or eyes due to the lack of pigment cells (melanocytes)