Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
Bowed tendon Bowed tendon Tendinitis/tendonitis is inflammation of a tendon. Many times, the tendon tissue is torn. A bowed tendon is a horseman's term for a tendon after a horse has sustained an injury that caused the tendon fibers to be torn, and then healed with "bowed" appearance. Tendinitis usually involves disruption of the tendon fibers. It is most commonly seen in the superficial digital flexor tendon (SDFT) in a front leg—the tendon that runs down the back of the leg, closest to the surface. Tendinitis is uncommon in the deep digital flexor tendon (DDFT) of a front leg or either the