Halogen bond the electron density on H or X appears to be reduced. Electron density transfers results in a penetration of the van der Waals volumes. Halogens participating in halogen bonding include: iodine (I), bromine (Br), chlorine (Cl), and sometimes fluorine (F). All four halogens are capable of acting as XB donors (as proven through theoretical and experimental data) and follow the general trend: F < Cl < Br < I, with iodine normally forming the strongest interactions. Dihalogens (I, Br, etc.) tend to form strong halogen bonds. The strength and effectiveness of chlorine and fluorine in XB formation depend on the
Biological aspects of fluorine Biological aspects of fluorine Biological aspects of fluorine describes the effects of fluorine-containing compounds with life. Fluorine (F) itself is very rare in everyday life, but hundreds of fluorine-containing compounds occur as minerals, medicines, pesticides, and materials. Naturally occurring organofluorine compounds are extremely rare. Nonetheless, twenty percent of all commercialized pharmaceuticals contain fluorine, examples being Lipitor and Prozac. Manmade fluorinated compounds have also played a role in several noteworthy environmental concerns. Chlorofluorocarbons, once major components of numerous commercial aerosol products, have proven damaging to Earth's ozone layer and resulted in the wide-reaching Montreal Protocol (though in truth the chlorine in