Glycogen phosphorylase the site at which the enzyme binds to glycogen granules before initiating cleavage of terminal glucose molecules. In fact, 70% of dimeric phosphorylase in the cell exists as bound to glycogen granules rather than free floating. The inhibition of glycogen phosphorylase has been proposed as one method for treating type 2 diabetes. Since glucose production in the liver has been shown to increase in type 2 diabetes patients, inhibiting the release of glucose from the liver’s glycogen’s supplies appears to be a valid approach. The cloning of the human liver glycogen phosphorylase (HLGP) revealed a new allosteric binding site near
The body in traditional Chinese medicine of all the Yin and Yang energy in the body. The Kidneys also govern the endocrine system, receive air from the lungs, govern bones, govern teeth, control water in the body, and store essence. Dysfunction of the Kidneys leads to deficiencies of Yin or Yang. It also leads to imbalanced hormones, weak bones, an impaired sex drive, and dizziness. Water in excess leads to bipolar disorder. Depressive episodes are characterized by Kidney Yin excess while manic episodes are characterized by Kidney Yang excess. The Kidney Meridian begins on the sole, moves up the inner leg to the groin, up the