Menstrual cycle and the lining of the uterus thickens. Follicles in the ovary begin developing under the influence of a complex interplay of hormones, and after several days one or occasionally two become dominant (non-dominant follicles shrink and die). Approximately mid-cycle, 24–36 hours after the luteinizing hormone (LH) surges, the dominant follicle releases an ovocyte, in an event called ovulation. After ovulation, the ovocyte only lives for 24 hours or less without fertilization while the remains of the dominant follicle in the ovary become a corpus luteum; this body has a primary function of producing large amounts of progesterone. Under the influence
Progesterone carboxymethyloxime potassium salt) showed water solubility that was increased by more than four orders of magnitude relative to progesterone (solubility = 9.44 mol/L and 0.0006 mol/L, respectively). In addition, it showed an "in vitro" terminal half-life in rat liver microsomes that was 363-fold longer than that of progesterone (half-life = 795.5 minutes and 2.2 minutes, respectively). As such, P4-3-CMO could have both improved absorption and increased metabolic stability relative to progesterone. However, the compound has not been further assessed nor studied in humans. Progesterone carboxymethyloxime Progesterone carboxymethyloxime, or progesterone 3-("O"-carboxymethyl)oxime (P4-3-CMO), is a progestin which was never marketed. It is an