Physiology of marathons amounts of blood to and from the lungs to reach all bodily tissues is dependent on having a high cardiac output along with sufficient levels of total body hemoglobin. Hemoglobin is the oxygen carrying protein within blood cells that allows for the proper transportation of oxygen from the lungs to other bodily tissues via the circulatory system. In order for the transportation of oxygen in blood to be effective during a marathon, the distribution of blood needs to be equally efficient in order for a marathoner's oxygen demands to be met during a race. The mechanism that allows for this
Effect of spaceflight on the human body enough oxygen to the brain without the astronaut's fainting or becoming dizzy. "Under the effects of the earth's gravity, blood and other body fluids are pulled towards the lower body. When gravity is taken away or reduced during space exploration, the blood tends to collect in the upper body instead, resulting in facial edema and other unwelcome side effects. Upon return to earth, the blood begins to pool in the lower extremities again, resulting in orthostatic hypotension." In 2013 NASA published a study that found changes to the eyes and eyesight of monkeys with spaceflights longer than 6 months. Noted