Versican other inflammatory cells) can migrate more easily through extracellular matrix that has a higher versican content. Deposits of versican are not present in normal skin but are found in the reticular dermis during keloid scarring, a condition where scar formation becomes uncontrolled and overgrowth of skin tissue occurs at the site of the wound. Versican has been shown to interact with hyaluronan and a link protein (hyaluronan and proteoglycan link protein 1; HAPLN1). Versican Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the "VCAN" gene. Versican is a
The Madness of King Scar primarily positive reviews from music critics. Ben Hewis of WhatsOnStage.com included the song in his list of his top five favorite show tunes, writing that it "shin[ed] a humanising light on the thought process of Scar is brilliantly effective storytelling". Hewis found the track to be an interesting exploration of Scar, and felt its removal from current productions of the musical was disappointing. Featuring it as an example of why Scar was one of the "15 most terrifying musical theater villains", "Backstage"'s KC Wright described it as a "snarling signature song". Megan Green of Australian Stage wrote that "The Madness