Transgender hormone therapy (male-to-female) medical professional. Inducers of CYP3A4 and other cytochrome P450 enzymes can reduce the effects of MTF HRT. A variety of different sex-hormonal medications are used in feminizing hormone therapy for transgender women. These include estrogens to induce feminization and suppress testosterone levels; antiandrogens such as androgen receptor antagonists, antigonadotropins, GnRH modulators, and 5α-reductase inhibitors to further oppose the effects of androgens like testosterone; and progestogens for various possible though uncertain benefits. Estrogens are the major sex hormones in women, and are responsible for the development and maintenance of feminine secondary sexual characteristics, such as breasts, wide hips, and a feminine
Sexual Preference (book) that while Bell "et al."′s suggestion that biological factors have a stronger influence on exclusive homosexuality than they have on bisexuality may seem plausible, it has not been directly tested and appears to conflict with available evidence, such as that concerning prenatal hormone exposure. The psychologist Bruce Rind credited Bell "et al." with disproving psychoanalytic theories about the development of homosexuality, along with the idea that childhood seduction causes homosexuality. The psychologist Mark Yarhouse wrote that while "Sexual Preference" is cited by proponents of a biological explanation, it relies on retrospective memory recall, which can be unreliable. The psychologist J.