Valerian (herb) particular binding site. Hydrophilic extractions of the herb commonly sold over the counter, however, probably do not contain significant amounts of isovaltrate. Valerenic acid in valerian stimulates serotonin receptors as a partial agonist, including 5-HT which is implicated in the sleep-wake cycle. The chief constituent of valerian is a yellowish-green to brownish-yellow oil present in the dried root, varying in content from 0.5 to 2.0%. This variation in quantity may be determined by location; a dry, stony soil yields a root richer in oil than moist, fertile soil. The volatile oils that form the active ingredient are pungent, somewhat reminiscent
Valerian Kuybyshev Valerian Kuybyshev Valerian Vladimirovich Kuybyshev (; – 25 January 1935) was a Russian revolutionary, Red Army officer, and prominent Soviet politician. Kuybyshev was born in Omsk in the Russian Empire on . He studied at the Omsk Military Cadet School. He joined the Bolshevik faction of the Russian Social Democratic Labour Party in 1904. The following year, he entered a military medical academy, but was expelled in 1906 for controversial political activities. Between 1906 and 1914, Kuybyshev performed subversive activities for the Bolsheviks throughout the Empire, for which he was exiled to Narym in Siberia where—together with Yakov Sverdlov—he set