Circulatory system that were cut during life bleed. He ascribed the fact to the phenomenon that air escaping from an artery is replaced with blood that entered by very small vessels between veins and arteries. Thus he apparently postulated capillaries but with reversed flow of blood. In 2nd century AD Rome, the Greek physician Galen knew that blood vessels carried blood and identified venous (dark red) and arterial (brighter and thinner) blood, each with distinct and separate functions. Growth and energy were derived from venous blood created in the liver from chyle, while arterial blood gave vitality by containing pneuma (air) and
Helicine arteries of penis in increased levels of cyclic guanosine monophosphate (cGMP). cGMP in turn triggers relaxation of the smooth muscle and results in dilation of blood vessels. This signal is terminated when cGMP is broken down by the enzyme cGMP specific phosphodiesterase type 5 (PDE5), the enzyme that is targeted by sildenafil and other drugs that treat erectile dysfunction. By preventing PDE5 from breaking down cGMP, the effects of NO are amplified and vasodilation occurs, thus resulting in increased penile erection. Helicine arteries of penis The helicine arteries of penis are arteries in the penis. They are found in the corpora cavernosa penis.