Antibiotic use in dentistry of bacteria from advanced caries. The first line of treatment is the removal of the source of inflammation or infection by local operative measures. Generally, the abscess can be eradicated through surgical drainage alone; however this is sometimes inadequate. Therefore, systemic antibiotic treatment may be required, but only if there is evidence of spreading infection. As the bacteria involved are known, antibiotic therapy selection can be specific, based on published susceptibilities. Penicillin in the form of amoxicillin is the most common antibiotic to use. However, 3% of the patient population is allergic to penicillin, so erythromycin is often used in
A22 (antibiotic) A22 binds directly to the actin homolog MreB in its nucleotide-binding pocket, blocking simultaneous ATP binding. As a consequence, A22 inhibits MreB polymerization and thus disrupts the cytoskeleton of bacteria, causing defects of morphology and chromosome segregation. A22 (antibiotic) A22, also known as "S"-(3,4-dichlorbenzyl)isothiourea, is a chemical compound with antibiotic activity. It is colorless, hygroscopic, and light-sensitive. A22 acts as a reversible inhibitor of the bacterial cell wall protein MreB, causing bacterial rod-shaped cells to form coccoid cells. The antibiotic activity of A22 has been studied primarily in "Pseudomonas aeruginosa." However, A22 does not seem to be useful as an