Pituitary gland lobe synthesizes and secretes melanocyte-stimulating hormone. The posterior pituitary (or neurohypophysis) is a lobe of the gland that is functionally connected to the hypothalamus by the median eminence via a small tube called the pituitary stalk (also called the infundibular stalk or the infundibulum). Hormones secreted from the pituitary gland help in controlling growth, blood pressure, energy management, all functions of the sex organs, thyroid glands and metabolism as well as some aspects of pregnancy, childbirth, nursing, water/salt concentration at the kidneys, temperature regulation and pain relief. The pituitary gland, in humans, is a pea-sized gland that sits in a
Pituitary adenoma showed that acromegaly cases with "AIP" mutations occurred about 20 years before acromegaly cases without "AIP" mutations and these tumors are large and relatively treatment resistant. Due to their young age at onset, "AIP" mutations are the most frequent genetic cause of pituitary gigantism (29% of cases). X-LAG is a rare syndrome of very early childhood onset pituitary tumors/hyperplasia that leads to growth hormone excess and severe overgrowth and pituitary gigantism. Three FIPA families with X-LAG have been reported to date all of which had transmission of a chromosome Xq26.3 duplication from affected mother to affected son . The disease