Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
Material of the Future a worldwide view from a variety of perspectives considering what the true value of plastic is. Covered topics include re-usable plastics, plastic pollution, plastic industry, controversies of plastic recycling, bioplastics, and plastics in human health. The film includes footage from Chinese recycling facilities, the world's largest plastics convention, the Los Angeles bag ban, heart replacement surgery, the Plasticarium in Brussels, and is interspersed with interviews from scientists, authors, artists, and environmentalists. The film is scored by Richard Swift with additional music from Baths and a previously unreleased track from Animal Collective. Material of the Future Material of the Future is