Muscarinic antagonist brain, involving both increased levels of acetylcholine and degeneration of dopaminergic pathways (nigrostriatal pathway). Thus, in parkinsonism there is decreased level of dopaminergic activity. One method of balancing the neurotransmitters is through blocking central cholinergic activity using muscarinic receptor antagonists. Atropine acts on the M2 receptors of the heart and antagonizes the activity of acetylcholine. It causes tachycardia by blocking vagal effects on the sinoatrial node. Acetylcholine hyperpolarizes the sinoatrial node, which is overcome by MRA and thus increases the heart rate. If atropine is given by intramuscular or subcutaneous injection, it causes initial bradycardia. This is because by i.m/s.c
Node (circuits) Dots used to mark nodes on a circuit diagram are sometimes referred to as "meatballs". Node (circuits) In electrical engineering, a node is any point on a circuit where the terminals of two or more circuit elements meet. In circuit diagrams, connections are ideal wires with zero resistance, so a node may consist of the entire section of wire between elements, not just a single point. According to Ohm's law, "V = IR", the voltage across any two points of a node with negligible resistance is showing that the voltage at every point of a node is the same. However,