Tendon induce endothelial cell proliferation and migration, and VEGF mRNA has been shown to be expressed at the site of tendon injuries along with collagen I mRNA. Bone morphogenetic proteins (BMPs) are a subgroup of TGF-β superfamily that can induce bone and cartilage formation as well as tissue differentiation, and BMP-12 specifically has been shown to influence formation and differentiation of tendon tissue and to promote fibrogenesis. In animal models, extensive studies have been conducted to investigate the effects of mechanical strain in the form of activity level on tendon injury and healing. While stretching can disrupt healing during the initial
What a piece of work is a man lines written by Montaigne: However, rather than being a direct influence on Shakespeare, Montaigne may have merely been reacting to the same general atmosphere of the time, making the source of these lines one of context rather than direct influence. What a piece of work is a man "What a piece of work is man!" is a phrase within a soliloquy by Prince Hamlet in William Shakespeare's play of the same name. Hamlet is reflecting, at first admiringly, and then despairingly, on the human condition. The soliloquy, spoken in the play by Prince Hamlet to Rosencrantz and Guildenstern in Act