The Primordial Emotions Denton distinguishes between primordial emotions, "imperious states of arousal and compelling intentions to act" (p. 7) driven by activation of interoceptors and involving ancient, lower brain regions such as the medulla, midbrain and hypothalamus, and "classic" emotions, such as anger, fear and love, driven by distance receptors (vision, hearing, olfaction) and mediated by higher, more recently evolved brain regions. The Primordial Emotions The Primordial Emotions: The Dawning of Consciousness is a 2006 book by the Australian neuroscientist Derek Denton. Denton argues that, if self-awareness and intentionality are intrinsic to consciousness, the primordial emotions such as thirst, hunger and pain (that
Antigen transfer in the thymus in thymic medulla, namely clonal deletion ("recessive tolerance") and T Regulatory cells selection ("dominant tolerance") which force autoreactive T cells to apoptosis or skew them into suppressor T regulatory cells (TRegs), respectively, in order to protect body against manifestations of autoimmunity. These processes are mediated especially by unique subset of stromal cells called Medullary thymic epithelial cells (mTECs) via presentation of Tissue restricted antigens (TRAs) that represent self tissues from almost all parts of the body. mTECs are not only capable to present TRAs as efficient APCs. They are also potent in production of these TRAs via unique process called