Lateral hypothalamus an OX1-induced CB1 pressor response in the rostral ventrolateral medulla. Narcolepsy is associated with a marked reduction in the number of orexinergic projection neurons from the lateral hypothalamus and very low orexin peptides in cerebrospinal fluid. This has been identified as the mechanism responsible for narcoleptic symptoms. Evidence suggest that OX1 neurons that synapse onto the dorsal nucleus of the vagus nerve and parts of the brain stem may play a role in the pathophysiology of chronic pain and visceral hypersensitivity in functional gastrointestinal disorders. Lateral hypothalamus The lateral hypothalamus, also called the lateral hypothalamic area, contains the primary orexinergic
Ventromedial nucleus of the hypothalamus propagation of seizure discharge to enter the brainstem seizure system. Ventromedial nucleus of the hypothalamus The ventromedial nucleus of the hypothalamus (VMN, also sometimes referred to as the ventromedial hypothalamus, VMH) is a nucleus of the hypothalamus. "The ventromedial hypothalamus (VMH) is a distinct morphological nucleus involved in terminating hunger, fear, thermoregulation, and sexual activity." This nuclear region is involved with the recognition of the feeling of fullness. It has four subdivisions: These subdivisions differ anatomically, neurochemically, and behaviorally. The ventromedial nucleus (VMN) is most commonly associated with satiety. Early studies showed that VMN lesions caused over-eating and obesity in