Apparent mineralocorticoid excess syndrome cases recorded worldwide. Liquorice consumption may also cause a temporary form of AME due to its ability to block 11β-hydroxysteroid dehydrogenase type 2, in turn causing increased levels of cortisol. Cessation of licorice consumption will reverse this form of AME. Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In
Water organ a consonance …. Countless gentlemen could not believe that this organ played by itself, according to the registers, with water, but they rather thought that there was somebody inside'. Besides automatically playing at least three pieces of music, it is now known that the organ was also provided with a keyboard. Other Italian gardens with water organs were at Pratolino, near Florence (c. 1575), Isola de Belvedere, Ferrara (before 1599), Palazzo del Quirinale, Rome (built by Luca Biagi in 1598, restored 1990), Villa Aldobrandini, Frascati (1620), one of the Royal Palaces at Naples (1746), Villa Doria Pamphili, Rome (1758–9). Of