Valerian (herb) some affinity for the GABA receptor, a class of receptors on which benzodiazepines are known to act. Valeric acid, which is responsible for the typical odor of mostly older valerian roots, does not have any sedative properties. Valeric acid is related to valproic acid, a widely prescribed anticonvulsant; valproic acid is a derivative of valeric acid. Valerian also contains isovaltrate, which has been shown to be an inverse agonist for adenosine A receptor sites. This action likely does not contribute to the herb's possible sedative effects, which would be expected from an agonist, rather than an inverse agonist, at this
Valerian and the City of a Thousand Planets saying "the vividness of this place only underscores the lifelessness of the people leading us through it ... There are 394 million stories on the City of a Thousand Planets, and Valerian’s might be the only one we’ve seen before. Still, any excuse to visit this place is one worth taking." Peter Sciretta of /Film touted the first half of "Valerian" as "unpredictable and bonkers insane", while calling the second half more formulaic and "far less exciting", though he still encouraged seeing the film in 3D "on the biggest screen possible". Ignatiy Vishnevetsky of "The A.V. Club" wrote that it