Development of the digestive system Development of the digestive system The development of the digestive system concerns the epithelium of the digestive system and the parenchyma of its derivatives, which originate from the endoderm. Connective tissue, muscular components, and peritoneal components originate in the mesoderm. Different regions of the gut tube such as the esophagus, stomach, duodenum, etc. are specified by a retinoic acid gradient that causes transcription factors unique to each region to be expressed. Differentiation of the gut and its derivatives depends upon reciprocal interactions between the gut endoderm and its surrounding mesoderm. Hox genes in the mesoderm are induced by a Hedgehog
Chronic airway-digestive inflammatory disease Chronic airway-digestive inflammatory disease Sinus disease, allergies, and asthma have been shown to be intimately related through recent research. Moreover, gastroesophageal reflux disease (GERD), laryngopharyngeal reflux disease (LPRD) and/or snoring or sleep apnea are often present as well. “Chronic Airway-Digestive Inflammatory Disease” (CAID) is a phrase which has been coined by Dr. Jordan S. Josephson, M.D., F.A.C.S. and Dr. Jens Ponikeau, M.D. to describe this very complex set of problems which are caused by inflammation. This term was first described in a book entitled Sinus Relief Now .CAID directly affects the upper respiratory system (the nose and the sinuses), the