Blood vessel vessels function to transport blood. In general, arteries and arterioles transport oxygenated blood from the lungs to the body and its organs, and veins and venules transport deoxygenated blood from the body to the lungs. Blood vessels also circulate blood throughout the circulatory system Oxygen (bound to hemoglobin in red blood cells) is the most critical nutrient carried by the blood. In all arteries apart from the pulmonary artery, hemoglobin is highly saturated (95–100%) with oxygen. In all veins apart from the pulmonary vein, the saturation of hemoglobin is about 75%. (The values are reversed in the pulmonary circulation.) In
Vein directly connect two capillary beds. Examples of such systems include the hepatic portal vein and hypophyseal portal system. The peripheral veins carry blood from the limbs and hands and feet. Microscopically, veins have a thick outer layer made of connective tissue, called the tunica externa or "tunica adventitia". There is a middle layer of bands of smooth muscle called tunica media, which are, in general, much thinner than those of arteries, as veins do not function primarily in a contractile manner and are not subject to the high pressures of systole, as arteries are. The interior is lined with endothelial