Glycogen synthase regulating glycogen/glucose levels and is activated by dephosphorylation. In humans, there are two paralogous isozymes of glycogen synthase: The liver enzyme expression is restricted to the liver, whereas the muscle enzyme is widely expressed. Liver glycogen serves as a storage pool to maintain the blood glucose level during fasting, whereas muscle glycogen synthesis accounts for disposal of up to 90% of ingested glucose. The role of muscle glycogen is as a reserve to provide energy during bursts of activity. Meanwhile, the muscle isozyme plays a major role in the cellular response to long-term adaptation to hypoxia. Notably, hypoxia only induces
Metropolitan Stores wholly owned Canadian subsidiary of Metropolitan Stores Ltd. to investment bankers James Richardson & Sons Ltd. of Winnipeg, Manitoba for approximately $19 million in cash, which returned the company to 100 per cent Canadian ownership. The agreement brought 86 stores and one warehouse located mainly in Ontario, Quebec and Winnipeg with annual sales in excess of $20 million and an annual profit after taxes of more than $1 million. Following the purchase, James Richardson & Sons transferred the business of Metropolitan Stores Ltd. to a newly formed Canadian corporation that became known as Metropolitan Stores of Canada Ltd. Two months