Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
The Water & the Blood sold on the Independent Albums chart. In addition, the album was the No. 17 most sold album on the Top Rock Albums chart the same week, with 7,000 copies sold. The album has sold 19,000 copies in the US as of April 2015. The Water & the Blood The Water & the Blood is the third studio album from Christian indie musician Dustin Kensrue, which was released on September 30, 2013 by BEC Recordings and Mars Hill Music, and the album was produced by Brian Eichelberger. The album has seen commercial and critical success. At Melodic.net, Tom Spinelli said that