Vitamin C megadosage Based on that study, the American Burn Association (ABA) considers high-dose ascorbic acid an option to be considered for adjuvant therapy in addition to the more accepted standard treatments. Atrial fibrillation (AF) is a common cardiac rhythm disturbance and it is associated with oxidative stress. Four meta-analyses have concluded that there is strong evidence that 1-2 g/day of vitamin C before and after cardiac operations can decrease the risk of post-operative AF. However, five randomized studies did not find benefit in the USA, so that the benefit was restricted to less wealthy countries. Exercise-induced bronchoconstriction (EIB) indicates acute narrowing of
Chemistry of ascorbic acid catalytically hydrogenated to sorbitol, which is then oxidized by the microorganism "Acetobacter suboxydans" to sorbose. Only one of the six hydroxy groups is oxidized by this enzymatic reaction. From this point, two routes are available. Treatment of the product with acetone in the presence of an acid catalyst converts four of the remaining hydroxyl groups to acetals. The unprotected hydroxyl group is oxidized to the carboxylic acid by reaction with the catalytic oxidant TEMPO (regenerated by sodium hypochlorite — bleaching solution). Historically, industrial preparation via the Reichstein process used potassium permanganate as the bleaching solution. Acid-catalyzed hydrolysis of this product