Exercise physiology loss of integrity to the blood brain barrier. Hyperthermia also can lower cerebral blood flow, and raise brain temperature. Researchers once attributed fatigue to a build-up of lactic acid in muscles. However, this is no longer believed. Rather, lactate may stop muscle fatigue by keeping muscles fully responding to nerve signals. The available oxygen and energy supply, and disturbances of muscle ion homeostasis are the main factor determining exercise performance, at least during brief very intense exercise. Each muscle contraction involves an action potential that activates voltage sensors, and so releases Ca ions from the muscle fibre’s sarcoplasmic reticulum. The
The Net (substance) The Net (substance) The Net, in alchemy, is an alloy of copper and iron, whose crystal structure induces a network pattern on its surface. It was described in the 17th century by Sir Isaac Newton. Newton produced the substance by following what he regarded as a recipe, encoded in classical mythology, for part of the process of achieving the philosopher's stone. The relevant myth involved the god Vulcan finding his wife Venus (alchemical symbol for copper) in bed with the god Mars (alchemical symbol for iron) Newton's interpretation rested on typical alchemical associations, construing Vulcan as a stand-in for fire,