Nucleated red blood cell in the normal development of a normoblast. A megaloblast is an unusually large erythroblast that can be associated with vitamin B deficiency (caused by pernicious anemia or dietary insufficiency), folic acid deficiency, or both (such anemias are collectively called megaloblastic anemias). This kind of anemia leads to macrocytes (abnormally large red cells) and the condition called macrocytosis. The cause of this cellular gigantism is an impairment in DNA replication that delays nuclear maturation and cell division. Because RNA and cytoplasmic elements are synthesized at a constant rate despite the cells' impaired DNA synthesis, the cells show nuclear-cytoplasmic asynchrony. NRB's can
Blood Red Horse Blood Red Horse Blood Red Horse is a 2004 young adult historical novel by author K M Grant. The book was published in 2004 by Puffin Books and in the US in 2005 by Walker Children's. "Blood Red Horse" is the first novel in the De Granville Trilogy and was followed by the books "Green Jasper" and "Blaze of Silver". In 2006 the audiobook version of "Blood Red Horse" won an AudioFile Earphones Award and in 2007 was one of YALSA's recommended audiobooks for 2007. "Blood Red Horse" follows Will and Ellie, two young teens growing up during the time