Endocrine gland atrophy, or active destruction. Hyperfunction can occur as a result of hypersecretion, loss of suppression, hyperplastic or neoplastic change, or hyperstimulation. Endocrinopathies are classified as primary, secondary, or tertiary. Primary endocrine disease inhibits the action of downstream glands. Secondary endocrine disease is indicative of a problem with the pituitary gland. Tertiary endocrine disease is associated with dysfunction of the hypothalamus and its releasing hormones. As the thyroid, and hormones have been implicated in signaling distant tissues to proliferate, for example, the estrogen receptor has been shown to be involved in certain breast cancers. Endocrine, paracrine, and autocrine signaling have all
Building control body Building control body A building control body is an organisation authorised to control building work that is subject to the Building Regulations in England and Wales (similar systems are provided in Northern Ireland, and in Scotland where the term 'building standards' is used). Building control roles are exercised by officers in local authorities and by private sector Approved Inspectors. The title "Building control officer" (BCO) (also known as a "building inspector" or a "building control surveyor") is used predominantly by local authorities, which confer the title of "officer" to many staff who have regulatory, supervision or enforcement roles. Private sector