Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Blood: Water Mission to $300,000 to provide clean water projects, clinics and educational opportunities for people in Africa while educating people in countless communities across America about the water & HIV/AIDS crises many Africans face every day. This year they will be cycling across the southern half of the United States and north along the Pacific Coast to provide people in Marsabit, Kenya with clean drinking water, hygiene & sanitation education and latrines. Blood: Water Mission Blood: Water Mission is a grassroots organization that empowers communities to work together against the HIV/AIDS and water crises in Africa. Co-founded by the multi-platinum, Grammy Award-winning