Antibiotic resistance in gonorrhea Antibiotic resistance in gonorrhea The Gonorrhea bacterium Neisseria gonorrhoeae has developed antibiotic resistance to many antibiotics. The bacteria was first identified in 1879, although some Biblical scholars believe that references to the disease can be found as early as Parshat Metzora of the Old Testament. In the 1940s effective treatment with penicillin became available, but by the 1970s resistant strains predominated. Resistance to penicillin has developed through two mechanisms: chromasomally mediated resistance (CMRNG) and penicillinase-mediated resistance (PPNG). CMRNG involves step wise mutation of penA, which codes for the penicillin-binding protein (PBP-2); mtr, which encodes an efflux pump that removes penicillin
Antibiotic gastric juices and hydrogen peroxide). It also excluded synthetic antibacterial compounds such as the sulfonamides. In current usage, the term "antibiotic" is applied to any medication that kills bacteria or inhibits their growth, regardless of whether that medication is produced by a microorganism or not. The term "antibiotic" derives from "anti" + βιωτικός ("biōtikos"), "fit for life, lively", which comes from βίωσις ("biōsis"), "way of life", and that from βίος ("bios"), "life". The term "antibacterial" derives from Greek ἀντί ("anti"), "against" + βακτήριον ("baktērion"), diminutive of βακτηρία ("baktēria"), "staff, cane", because the first bacteria to be discovered were rod-shaped. The