Nav1.5 kb. The gene consists of 28 exons, of which exon 1 and in part exon 2 form the 5’ untranslated region (5’UTR) and exon 28 the 3’ untranslated region (3’UTR) of the RNA. SCN5A is part of a family of 10 genes that encode different types of sodium channels, i.e. brain-type (Na1.1, Na1.2, Na1.3, Na1.6), neuronal channels (Na1.7, Na1.8 and Na1.9), skeletal muscle channels (Na1.4) and the cardiac sodium channel Na1.5. SCN5A is mainly expressed in the heart, where expression is abundant in working myocardium and conduction tissue. In contrast, expression is low in the sinoatrial node and atrioventricular node.
Sentinel node list, can be simplified remarkably using a sentinel node to demarcate the beginning and end of the list. Following is a Python implementation of a circular doubly-linked list: Notice how the codice_13 method takes the node that will be displaced by the new node in the parameter codice_14. For appending to the left, this is the head of a non-empty list, while for appending to right, it is the tail. But because of how the linkage is setup to refer back to the sentinel, the code just works for empty lists as well, where codice_14 will be the sentinel node.