Artificial hair integrations is a type of synthetic fiber that can withstand heat up to 400 °F (200 °C), and can actually outlast human hair. It is very similar to human hair given it is tangle-free and has a natural sheen. It can be straightened or curled, however, it takes longer to set and futura cannot be colored. It is sometimes sold as a human hair blend. The human hair shaft is made up of dead, hard protein, called keratin, in three layers. The inner layer is called the medulla and may not be present. The next layer is the cortex and the
Retinoblastoma protein of DREAM requires DYRK1A (Ser/Thr kinase) dependant phosphorylation of the MuvB core component, Lin52 at Serine28. This mechanism is crucial for recruitment of p130/p107 to the MuvB core and thus DREAM assembly. The retinoblastoma protein is involved in the growth and development of mammalian hair cells of the cochlea, and appears to be related to the cells' inability to regenerate. Embryonic hair cells require Rb, among other important proteins, to exit the cell-cycle and stop dividing, which allows maturation of the auditory system. Once wild-type mammals have reached adulthood, their cochlear hair cells become incapable of proliferation. In studies where