Insulin glargine Insulin glargine Insulin glargine, marketed under the names Lantus, among others, is a long-acting basal insulin analogue, given once daily to help control the blood sugar level of those with diabetes. It consists of microcrystals that slowly release insulin, giving a long duration of action of 18 to 26 hours, with a "peakless" profile (according to the insulin glargine package insert). Pharmacokinetically, its steady action can supplement the variable insulin secretion of non-diabetic pancreatic beta cells. Sometimes, in type 2 diabetes and in combination with a short acting sulfonylurea (drugs which stimulate the pancreas to make more insulin), it can
Insulin pump being injected, or if the cannula becomes bent or kinked in the body, preventing delivery. Therefore, pump users typically monitor their blood sugars more frequently to evaluate the effectiveness of insulin delivery. Use of insulin pumps is increasing because of: In 1963 Dr. Arnold Kadish designed the first insulin pump to be worn as a backpack. A more wearable version was later devised by Dean Kamen in 1976. Kamen formed a company called "AutoSyringe" to market the product, which he sold to Baxter Health Care in 1981. The insulin pump was first endorsed in the United Kingdom in 2003, by