Antibiotic synergy with enterococcal endocarditis experienced a high relapse rate when penicillin G alone was used for treatment and a demonstrably lower relapse rate when streptomycin was combined with penicillin G to combat the infection. Since that time the research community has conducted numerous studies regarding the effects and possibilities of antibiotic combinations. Today, combination therapy is recognized as providing a broad spectrum of antibiotic coverage, effectively fighting polymicrobial infections, minimizing selection for antibiotic resistant strains, lowering dose toxicity where applicable, and in some cases providing synergistic activity. Antibiotic synergy is desirable in a clinic sense for several reasons. At the patient
Antibiotic use in livestock antibiotic given to the livestock. Since the primary study, there have been many well-documented events showing that antibiotic usage in livestock results in direct influence of antibiotic resistance in humans. Major bacterial infections in humans can be traced back to livestock. The family Enterobacteriaceae includes many opportunistic bacteria, including "E. coli", which are commonly found in livestock. Other bacteria include "Klebsiella" and "Staphylococcus aureus". They cause infections in the urinary tract, digestive system, skin, and bloodstream, and account for a significant portion of antibiotic-resistant bacterial infections. The practice of using antibiotics for growth stimulation is problematic for these reasons: Donald