Apparent mineralocorticoid excess syndrome cases recorded worldwide. Liquorice consumption may also cause a temporary form of AME due to its ability to block 11β-hydroxysteroid dehydrogenase type 2, in turn causing increased levels of cortisol. Cessation of licorice consumption will reverse this form of AME. Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In
Water organ in the gardens at Heilbronn, Württemberg, and parts of one at the Wilhelmshöhe gardens in Kassel. The brothers Francini constructed waterworks and organs at Saint Germain-en-Laye and Versailles, which reached new heights of splendour and extravagance. By the end of the 17th century, however, interest in water organs had waned. As their upkeep was costly they were left to decay and were soon forgotten; by 1920 not one survived (the so-called water organ at Hellbrunn Castle, Salzburg, is a pneumatic organ driven by hydraulically operated bellows). Their mechanism was subsequently misunderstood until the Dutch engineer Van Dijk pointed out in