Protein signalling in heart development Protein signalling in heart development The heart is the first functional organ in a vertebrate embryo. There are 5 stages to heart development. Specification of cardiac precursor cells: The lateral plate mesoderm delaminates to form two layers: the dorsal somatic (parietal) mesoderm and the ventral splanchnic (visceral) mesoderm. The heart precursor cells come from the two regions of the splanchnic mesoderm called the cardiogenic mesoderm. These cells can differentiate into endocardium which lines the heart chamber and valves and the myocardium which forms the musculature of the ventricles and the atria. The heart cells are specified in anterior mesoderm by
How Many Licks? cover version of "How Many Licks?", which Josh Middleton of the "Philadelphia" praised as "outstanding". Credits adapted from the liner notes of "The Notorious K.I.M.". How Many Licks? "How Many Licks?" is a song by American rapper Lil' Kim featuring vocals by American musician Sisqó from her second studio album, "The Notorious K.I.M." (2000). It was released as the record's second single in 2000. Mario Winans and Sean Combs produced "How Many Licks?", and wrote it with Lil' Kim and Sisqó. The hip hop song samples the "Knight Rider" theme song, with lyrics expressing a woman's desire for oral sex