Salicylic acid the product with sulfuric acid gives salicylic acid: It can also be prepared by the hydrolysis of aspirin (acetylsalicylic acid) or methyl salicylate (oil of wintergreen) with a strong acid or base. Hippocrates, Galen, Pliny the Elder and others knew that willow bark could ease pain and reduce fevers. It was used in Europe and China to treat these conditions. This remedy is mentioned in texts from ancient Egypt, Sumer and Assyria. The Cherokee and other Native Americans used an infusion of the bark for fever and other medicinal purposes. In 2014, archaeologists identified traces of salicylic acid on 7th
Moronic acid Moronic acid Moronic acid (3-oxoolean-18-en-28-oic acid) is a natural triterpene. Moronic acid can be extracted from "Rhus javanica", a sumac plant traditionally believed to hold medicinal applications. The molecule has also been extracted from Mistletoe ("Phoradendron reichenbachianum"). Bevirimat, a derivative of the related triterpenoid betulinic acid, is under development as an anti-HIV drug; however, moronic acid has shown better antiviral profiles "in vitro" than bevirimat. A particular moronic acid derivative showed potent anti-HIV activity with EC values of 0.0085 μM against NL4-3, 0.021 μM against PI-R (a multiple protease inhibitor resistant strain), and 0.13 μM against FHR-2 (an HIV strain