Pacemaker current on hyperpolarization, and very slow kinetics. The funny current is highly expressed in spontaneously active cardiac regions, such as the sinoatrial node (SAN, the natural pacemaker region), the atrioventricular node (AVN) and the Purkinje fibres of conduction tissue. The funny current is a mixed sodium–potassium current that activates upon hyperpolarization at voltages in the diastolic range (normally from −60/−70 mV to −40 mV). When, at the end of a sinoatrial action potential, the membrane repolarizes below the I threshold (about −40/−50 mV), the funny current is activated and supplies inward current, which is responsible for starting the diastolic depolarization phase
Node (circuits) Node (circuits) In electrical engineering, a node is any point on a circuit where the terminals of two or more circuit elements meet. In circuit diagrams, connections are ideal wires with zero resistance, so a node may consist of the entire section of wire between elements, not just a single point. According to Ohm's law, "V = IR", the voltage across any two points of a node with negligible resistance is showing that the voltage at every point of a node is the same. However, there are some notable exceptions where the voltage difference is large enough to become significant: