Ear pain with several weeks of IV and oral antibiotics, usually fluoroquinolones. Acute otitis media is an infection of the middle ear. More than 80% of children experience at least one episode of otitis media by age 3 years. Acute otitis media is also most common in these first 3 years of life, though older children may also experience it. The most common causative bacteria are "Streptococcus pneumoniae", "Haemophilus influenzae", and "Moraxella catarrhalis". Otitis media often occurs with or following cold symptoms. The diagnosis is made by the combination of symptoms and examination of the tympanic membrane for redness, bulging, and/or a
Plasma membrane H+-ATPase Plasma membrane H+-ATPase This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. To be specific, the protein is a part of the P-type ATPase family. The systematic name of this enzyme class is ATP phosphohydrolase (-exporting). -exporting ATPase is also known as proton ATPase or more simply proton pump. Other names in common use include proton-translocating ATPase, yeast plasma membrane -ATPase, plant plasma membrane -ATPase, yeast plasma membrane ATPase, plant plasma membrane ATPase, and ATP phosphohydrolase. The yeast (Saccharomyces cerevisiae) enzyme is encoded by the gene Pma1 and hence