Retina bipolar cell it, either through a metabotropic (ON) or ionotropic (OFF) receptor. However, the mechanism for producing the monochromatic surround of the same receptive field is under investigation. While it is known that an important cell in the process is the horizontal cell, the exact sequence of receptors and molecules is unknown. Retina bipolar cell As a part of the retina, bipolar cells exist between photoreceptors (rod cells and cone cells) and ganglion cells. They act, directly or indirectly, to transmit signals from the photoreceptors to the ganglion cells. Bipolar cells are so-named as they have a central body from which two
Retina of the retina. Recombinant adeno-associated virus (rAAV) vectors possess a number of features that render them ideally suited for retinal gene therapy, including a lack of pathogenicity, minimal immunogenicity, and the ability to transduce postmitotic cells in a stable and efficient manner. rAAV vectors are increasingly utilized for their ability to mediate efficient transduction of retinal pigment epithelium (RPE), photoreceptor cells and retinal ganglion cells. Each cell type can be specifically targeted by choosing the appropriate combination of AAV serotype, promoter, and intraocular injection site. Several clinical trials have already reported positive results using rAAV to treat Leber's congenital amaurosis,