Tendon the presence of denatured collagen are factors that are believed to cause weakening of the tendon ECM and an increase in the potential for another rupture to occur. In response to repeated mechanical loading or injury, cytokines may be released by tenocytes and can induce the release of MMPs, causing degradation of the ECM and leading to recurring injury and chronic tendinopathies. A variety of other molecules are involved in tendon repair and regeneration. There are five growth factors that have been shown to be significantly upregulated and active during tendon healing: insulin-like growth factor 1 (IGF-I), platelet-derived growth factor
Elastic and inelastic collisions apparatus of the Museo Galileo in Florence. Elastic and inelastic collisions apparatus The elastic and inelastic collisions apparatus is a large apparatus to study elastic and inelastic collisions. It consists of a large frame carrying two beams from which two rows of six and two wooden balls, respectively, are suspended from pairs of strings. The instrument was often used with two elastic balls (of ivory) or inelastic balls (of wet clay), of equal or different mass. By changing the parameters of the experiments such as height of fall and mass, one could conduct a systematic investigation of collision-related phenomena. For example,