Versican other inflammatory cells) can migrate more easily through extracellular matrix that has a higher versican content. Deposits of versican are not present in normal skin but are found in the reticular dermis during keloid scarring, a condition where scar formation becomes uncontrolled and overgrowth of skin tissue occurs at the site of the wound. Versican has been shown to interact with hyaluronan and a link protein (hyaluronan and proteoglycan link protein 1; HAPLN1). Versican Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the "VCAN" gene. Versican is a
Fibrous joint the tissue linking the structures is ligamentous. A gomphosis is a specialized fibrous joint in which a conical process or peg of one bone fits into a hole or socket in another bone. (gomphos is a Greek word meaning bolt). Small quantity of fibrous tissue holds the bones together. No movement is possible at such peg-and-socket joints. Fibrous joint Fibrous joints are connected by dense connective tissue, consisting mainly of collagen. These are fixed joints where bones are united by a layer of white fibrous tissue of varying thickness. In the skull the joints between the bones are called sutures.