History of aspirin Hermann Hildebrandt). In 1894, the young chemist Felix Hoffmann joined the pharmaceutical group. Dreser, Eichengrün and Hoffmann would be the key figures in the development of acetylsalicylic acid as the drug Aspirin (though their respective roles have been the subject of some contention). In 1897, Hoffmann started working to find a less irritating substitute for salicylic acid. It is generally accepted that he turned to this idea because his father was suffering the side effects of taking sodium salicylate for rheumatism. In 1853, Charles Frédéric Gerhardt had published the first methods to prepare acetylsalicylic acid. In the course of his
Technetium (99mTc) medronic acid Technetium (99mTc) medronic acid Technetium (Tc) medronic acid (MDP) is a pharmaceutical product used in nuclear medicine to localize bone metastases as well as other diseases that can alter the natural turn-over in the bone by bone scintigraphy. The drug is a complex of medronic acid, the simplest bisphosphonate, with technetium-99m (Tc), a radionuclide that emits gamma rays. The exact structure of the complex is not known. Tc-MDP must be prepared in a radiopharmacy. It is usually supplied as a "cold kit" to which radioactive Tc from a generator is added. Kit composition may vary between suppliers, but contents typically