Insulin (medication) testing and occasionally skin biopsy. First line therapy against insulin hypersensitivity reactions include symptomatic therapy with antihistamines. The affected persons are then switched to a preparation that does not contain the specific agent they are reacting to or undergo desensitization. Insulin is an endogenous hormone, which is produced by the pancreas. The insulin protein has been highly conserved across evolutionary time, and is present in both mammals and invertebrates. The insulin/insulin-like growth factor signalling pathway (IIS) has been extensively studied in species including nematode worms (e.g."C. elegans"), flies ("Drosophila melanogaster") and mice ("Mus musculus"). Its mechanisms of action are highly
British Institute of Organ Studies British Institute of Organ Studies The British Institute of Organ Studies, more commonly known by its acronym BIOS, is a British organisation and registered charity which aims to promote study and appreciation of all aspects of the pipe organ. Further, it acts as a lobbying body to raise awareness of organ issues with appropriate statutory bodies. Membership is open to all. The aims of BIOS are BIOS publishes a quarterly Reporter newsletter and magazine and a yearly Journal which contains articles on organ history. BIOS is also responsible for the National Pipe Organ Register (NPOR), which aims to catalogue all