Parasympathetic nervous system act in a complementary way increasing or slowing the heart rate. In this context, the vagus nerve acts on sinoatrial node slowing its conduction thus actively modulating vagal tone accordingly. This modulation is mediated by the neurotransmitter acetylcholine and downstream changes to ionic currents and calcium of heart cells. The vagus nerve plays a crucial role in heart rate regulation by modulating the response of sinoatrial node, vagal tone can be quantified by investigating heart rate modulation induced by vagal tone changes. As a general consideration, increased vagal tone (and thus vagal action) is associated with a diminished and more
Bachmann's bundle found that clamping the muscular bundle of fibers that connects the atria caused a significant conduction delay. The Bachman's bundle receives its blood supply from the sinoatrial nodal artery (right, left or both). Besides Bachmann's bundle, the other three conduction tracts that constitute the "atrial conduction system" are known as the anterior, middle, and posterior tracts, which run from the sinoatrial node to the atrioventricular node, converging in the region near the coronary sinus. "Atrial automaticity foci" are within the atrial conduction system. The concentration of converging conduction tracts near the coronary sinus results in considerable automaticity activity originating in