Valerian (herb) mild nervous tension and to aid sleep; EMA stated that although there is insufficient evidence from clinical studies, its effectiveness as a dried extract is considered plausible. In the United States, valerian extracts are sold as a nutritional supplement under the Dietary Supplement Health and Education Act of 1994. Oral forms are available in both standardized and unstandardized forms. Standardized products may be preferable considering the wide variation of the chemicals in the dried root, as noted above. When standardized, it is done so as a percentage of valerenic acid or valeric acid. Because the compounds in valerian produce central
Sedative benzodiazepines, when used as a hypnotic to induce sleep, tend to be higher than amounts used to relieve anxiety, whereas only low doses are needed to provide a peaceful effect. Sedatives can be misused to produce an overly-calming effect (alcohol being the classic and most common sedating drug). In the event of an overdose or if combined with another sedative, many of these drugs can cause unconsciousness (see hypnotic) and even death. There is some overlap between the terms "sedative" and "hypnotic". Advances in pharmacology have permitted more specific targeting of receptors, and greater selectivity of agents, which necessitates greater