Natural product to modern discovery of their active ingredients and eventually to the development of new drugs. A large number of currently prescribed drugs have been either directly derived from or inspired by natural products. A few representative examples are listed below. Some of the oldest natural product based drugs are analgesics. The bark of the willow tree has been known from antiquity to have pain relieving properties. This is due to presence of the natural product salicin which in turn may be hydrolyzed into salicylic acid. A synthetic derivative acetylsalicylic acid better known as aspirin is a widely used pain reliever.
U Should've Known Better Me" was shelved, the song was one out of five original records that were transferred into its new version, "After the Storm". Although a duet with DMX, "Don't Gotta Go Home", was expected be released as the album's fourth single at times, "U Should've Known Better" eventually replaced original plans. Released as the album's fourth and final single in March 2004, "U Should've Known Better" opened as the Hot Shot Debut of the week at number 72 on "Billboard"s Hot R&B/Hip-Hop Singles & Tracks chart in the week of April 3, 2004. However, it took another three months until the