Gonadal dysgenesis If a single or combination of these genes are mutated or deleted, downstream signalling is disrupted, leading to malformation of male external genitalia. SRY acts on gene SOX9 which drives Sertoli cell formation and testis differentiation. An absence in SRY causes SOX9 to not be expressed at the appropriate time or concentration, leading to a deficiency in testosterone and Anti-Müllerian hormone production. Inadequate levels of testosterone and Anti-Müllerian hormone disrupts the development of Wolffian ducts and internal genitalia that are key to male reproductive tract development. The lack of the male associated steroid hormones drives Müllerian duct development and perusal
Male lactation where male lactation occurs and it is not well understood what evolutionary factors control the development of this trait. The phenomenon of male lactation occurs in some species, notably the Dayak fruit bat ("Dyacopterus spadiceus"), and the lactating males may assist in the nursing of their infants. In addition, male goats are known to lactate on occasion. Human male breastfeeding is possible, but production of the hormone prolactin is necessary to induce lactation, so male lactation does not occur under normal conditions. Domperidone is a drug that can be used to increase lactation. Male lactation has also been seen during