Red blood cell macrophages and subsequent phagocytosis in the mononuclear phagocyte system (spleen, liver and lymph nodes), thus removing old and defective cells and continually purging the blood. This process is termed eryptosis, red blood cell programmed cell death. This process normally occurs at the same rate of production by erythropoiesis, balancing the total circulating red blood cell count. Eryptosis is increased in a wide variety of diseases including sepsis, haemolytic uremic syndrome, malaria, sickle cell anemia, beta-thalassemia, glucose-6-phosphate dehydrogenase deficiency, phosphate depletion, iron deficiency and Wilson's disease. Eryptosis can be elicited by osmotic shock, oxidative stress, energy depletion as well as a
White blood cell underlying cause, though the cause may not always be found. The complete blood cell count is a blood panel that includes the overall WBC count and various subsets such as the absolute neutrophil count. Reference ranges for blood tests specify the typical counts in healthy people. TLC- (Total leucocyte count): Normal TLC in an adult person is 6000-8000WBC/mm^3 of blood. DLC- (Differential leucocyte count): Number/ (%) of different type of leucocyte in per cubic mm. of blood. White blood cell White blood cells (also called leukocytes or leucocytes and abbreviated as WBCs) are the cells of the immune system that