John Jacob Abel to successfully isolate the neutral base of epinephrine by adding ammonium to highly concentrated extract, a method Abel himself tried but failed due to the use of low concentration of extract. After Takamine's success, Abel himself remarked, with great candor, "The efforts of years on my part in this once mysterious field of suprarenal, medullary biochemistry, marred by blunders as they were, eventuated, then, in the isolation of the hormone not in the form of the free base but in that of its monobenzoyl derivative." Together with L.G. Rowntree and B.B. Turner, Abel devised what they called a "vividiffusion" apparatus,
John Jacob Abel the first four years, but he continued to guide the scientists in his lab to unravel more and more about the structure of insulin molecule. Despite his great dedication to experimentation work, Abel's historical significance is certainly not restricted to his research work. He was also the founder of a number of influential scientific journals. As more and more research was conducted in the field of biochemistry, Abel realized the importance of having a platform that allowed scientists all around the world to publish their work and report on their findings. He therefore asked his friend Dr. C. A. Herter,