Antibiotic synergy with enterococcal endocarditis experienced a high relapse rate when penicillin G alone was used for treatment and a demonstrably lower relapse rate when streptomycin was combined with penicillin G to combat the infection. Since that time the research community has conducted numerous studies regarding the effects and possibilities of antibiotic combinations. Today, combination therapy is recognized as providing a broad spectrum of antibiotic coverage, effectively fighting polymicrobial infections, minimizing selection for antibiotic resistant strains, lowering dose toxicity where applicable, and in some cases providing synergistic activity. Antibiotic synergy is desirable in a clinic sense for several reasons. At the patient
Antibiotic prophylaxis background, training, nurse and pharmacist influences, medication supply, and logistics. The American Heart Association (AHA) now recommends antibiotic prophylaxis for very few patients since only a small number of cases of endocarditis might be prevented by this procedure. Antibiotic prophylaxis in domestic animal feed mixes has been employed in America since at least 1970. Over time, the use of antibiotics for growth promotion purposes in livestock was discovered. In 1986, some European countries banned the use of antibiotics because of research they found that linked antibiotic use in livestock and drug resistant bacteria in humans. The European Union regulated in