Versican other inflammatory cells) can migrate more easily through extracellular matrix that has a higher versican content. Deposits of versican are not present in normal skin but are found in the reticular dermis during keloid scarring, a condition where scar formation becomes uncontrolled and overgrowth of skin tissue occurs at the site of the wound. Versican has been shown to interact with hyaluronan and a link protein (hyaluronan and proteoglycan link protein 1; HAPLN1). Versican Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the "VCAN" gene. Versican is a
Circumcision scar in a fine, even scar. Circumcisions after the newborn period that are performed without sutures (techniques that use cyanoacrylate tissue adhesive instead of sutures and techniques like Plastibell that heal by secondary intention) often result in an even, circumferential scar. There is some controversy as to what happens to the severed nerves of the foreskin at the scar. Xin "et al". (1997) suggest that nerves regenerate, forming new receptors. However, pathologists Cold & Taylor (1999) report: "Histology of the male circumcision scar shows amputation neuromas, Schwann cell proliferation and the bulbous collection of variably sized neurites. Amputation neuromas do not