Light effects on circadian rhythm collected by rod cells and cone cells and the retinal ganglion cells (RGCs), or it is directly collected by these RGCs. The RGCs use the photopigment melanopsin to absorb the light energy. Specifically, this class of RGCs being discussed is referred to as "intrinsically photosensitive," which just means they are sensitive to light. There are five known types of intrinsically photosensitive retinal ganglion cells (ipRGCs): M1, M2, M3, M4, and M5. Each of these differently ipRGC types have different melanopsin content and photosensitivity. These connect to amacrine cells in the inner plexiform layer of the retina. Ultimately, via this retinohypothalamic
Optical stretcher stretcher, it was also shown that cancerous cells differ significantly in their mechanical properties from their healthy counterparts. The authors claim that the 'optical deformability' can be used as a biomechanical marker to distinguish cancerous from healthy cells, and even that higher stages of malignancy can be detected. A typical optical stretcher setup consists of the following main parts: Objects trapped in the optical stretcher usually have diameters on the scale of 10 micrometer, which is very large compared to the laser wavelengths used (often 1064 nm). It is thus sufficient to consider the interaction with the laser light in