Antibiotic resistance in gonorrhea mechanism for beta-lactam resistance. There have been over 200 beta-lactamases described and some of them are antibiotic specific. TEM-1 is a penicillinase specific for penicillins. This enzyme will bind to the beta-lactam ring which is a structural characteristic for beta-lactams and hydrolyze the ring. This renders the antibiotic inactive. The spread of the penicillinase resistance was much faster compared to the chromosomal-mediated resistance mechanisms. The plasmids containing TEM-1 could be passed from bacterium to bacterium via conjugation Quinolones are a class of synthetic antibiotics that inhibit DNA replication, recombination, and repair by interacting with the bacterial DNA gyrase and/or topoisomerase
The Teacher Who Was Not To Be of Music. In his letter Thommessen chastised Paus for his tonal music. A long monologue on why Paus has misunderstood everything about music ends with the words "I do not want any more verbal contact with you." At the time the opera monologue premiered, the "Teacher" in the monologue remained anonymous. The monologue played an important role in an extensive debate on musical aesthetics in the music journal "Ballade" in 2015, during which the formerly anonymous "Teacher" was revealed by Paus to be Olav Anton Thommessen. The Teacher Who Was Not To Be The Teacher Who Was Not To Be