Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
The Water & the Blood indeed." At "HM Magazine", Rob Houston evoked that the album "has some great, uplifting tracks, but as a full record, it is a bit of a letdown." Jason Whitehorn of "Worship Leader" called the release "cover to cover an intense personal worship album." At Jesus Freak Hideout, Michael Weaver felt that the album was "a definite must-have for someone longing for a deeper, more personal worship experience." Also, Jesus Freak Hideout's Ryan Barbee highlighted that ""The Water and the Blood" really shows excellent examples of, as Kensrue put it, satisfaction and grace." In addition, Barbee stated that "The collision of