Recreational drug use are caused by an excessive response of the body to allergens, such as the pollen released by grasses and trees. An allergic reaction causes release of histamine by the body. Other uses of antihistamines are to help with normal symptoms of insect stings even if there is no allergic reaction. Their recreational appeal exists mainly due to their anticholinergic properties, that induce anxiolysis and, in some cases such as diphenhydramine, chlorpheniramine, and orphenadrine, a characteristic euphoria at moderate doses. High dosages taken to induce recreational drug effects may lead to overdoses. Antihistamines are also consumed in combination with alcohol, particularly
Juniperus ashei and soft, pulpy and berry-like, green at first, maturing purple about 8 months after pollination. They contain 1–2 seeds, which are dispersed when birds eat the cones and pass the seeds in their droppings. The male cones are 3–5 mm long, yellow, turning brown after pollen release in December to February. The pollen causes a severe allergic reaction for some people in the winter, and people who are allergic to Ashe juniper are also often allergic to the related "Juniperus virginiana". Consequently, what begins as an allergy in the winter may extend into spring since the pollination of "J. virginiana"