Rimantadine antagonistic properties and is used as an antiparkinsonic drug (i.e., in the treatment of Parkinson's disease). However, in general, neither rimantadine nor amantadine is a preferred agent for this therapy and would be reserved for cases of the disease that are less responsive to front-line treatments. Taking paracetamol (acetaminophen, Tylenol) or acetylsalicylic acid (aspirin) while taking rimantadine is known to reduce the body's uptake of rimantadine by approximately 12%. Cimetidine also affects the body's uptake of rimantadine. Rimantadine can produce gastrointestinal and central nervous system adverse effects. Approximately 6% of patients (compared to 4% of patients taking a placebo) reported
Worse is better Rise of Worse is Better", Gabriel claimed that "Worse-is-Better" is a model of software design and implementation which has the following characteristics (in approximately descending order of importance): Gabriel argued that early Unix and C, developed by Bell Labs, are examples of this design approach. Gabriel contrasted his philosophy with what he called the "MIT/Stanford style of design" or "MIT approach" (also known as "the Right Thing"), which he described as follows. Contrasts are in bold: Gabriel argued that "Worse is better" produced more "successful" software than the MIT approach: As long as the initial program is basically good, it