Muscarinic antagonist brain, involving both increased levels of acetylcholine and degeneration of dopaminergic pathways (nigrostriatal pathway). Thus, in parkinsonism there is decreased level of dopaminergic activity. One method of balancing the neurotransmitters is through blocking central cholinergic activity using muscarinic receptor antagonists. Atropine acts on the M2 receptors of the heart and antagonizes the activity of acetylcholine. It causes tachycardia by blocking vagal effects on the sinoatrial node. Acetylcholine hyperpolarizes the sinoatrial node, which is overcome by MRA and thus increases the heart rate. If atropine is given by intramuscular or subcutaneous injection, it causes initial bradycardia. This is because by i.m/s.c
Node deletion Node deletion Node deletion is the procedure of removing a node from a network, where the node is either chosen randomly or directly. Node deletion is used to test the robustness and the attack tolerance of networks. Understanding how a network changes in response to node deletion is critical in many empirical networks. Application varies across many fields, including the breakdown of the World Wide Web via router removal, elimination of epidemics or fighting against criminal organizations. Removing a node or multiple nodes randomly from a network means that the elimination of a set of nodes happens with a certain