Muscarinic antagonist brain, involving both increased levels of acetylcholine and degeneration of dopaminergic pathways (nigrostriatal pathway). Thus, in parkinsonism there is decreased level of dopaminergic activity. One method of balancing the neurotransmitters is through blocking central cholinergic activity using muscarinic receptor antagonists. Atropine acts on the M2 receptors of the heart and antagonizes the activity of acetylcholine. It causes tachycardia by blocking vagal effects on the sinoatrial node. Acetylcholine hyperpolarizes the sinoatrial node, which is overcome by MRA and thus increases the heart rate. If atropine is given by intramuscular or subcutaneous injection, it causes initial bradycardia. This is because by i.m/s.c
Node (Well of Echoes) or node-drainers that drain the node of the field and render anything that draws power from it useless. Mancers who cannot draw from a distat node's field must rely on charged crystals, while clankers, constructs and any other devices of the Art will not work. There are also rare places called anti-nodes, where the Art does not work or is at least greatly reduced. Node (Well of Echoes) Nodes are fictional, naturally occurring phenomena in Ian Irvine’s "The Three Worlds Cycle" of novels. They often occur in places where there is a significant landmark, such as on a hill or