Nonsteroidal anti-inflammatory drug more effective than salicin and, in addition to its fever-reducing properties, is anti-inflammatory and analgesic. In 1869, Hermann Kolbe synthesised salicylate, although it was too acidic for the gastric mucosa. The reaction used to synthesise aromatic acid from a phenol in the presence of CO2 is known as the Kolbe-Schmitt reaction. By 1897 the German chemist Felix Hoffmann and the Bayer company prompted a new age of pharmacology by converting salicylic acid into acetylsalicylic acid—named aspirin by Heinrich Dreser. Other NSAIDs were developed from the 1950s forward. In 2001, NSAIDs accounted for 70,000,000 prescriptions and 30 billion over-the-counter doses sold
Technetium (99mTc) medronic acid Technetium (99mTc) medronic acid Technetium (Tc) medronic acid (MDP) is a pharmaceutical product used in nuclear medicine to localize bone metastases as well as other diseases that can alter the natural turn-over in the bone by bone scintigraphy. The drug is a complex of medronic acid, the simplest bisphosphonate, with technetium-99m (Tc), a radionuclide that emits gamma rays. The exact structure of the complex is not known. Tc-MDP must be prepared in a radiopharmacy. It is usually supplied as a "cold kit" to which radioactive Tc from a generator is added. Kit composition may vary between suppliers, but contents typically