Any Human Heart writing again of a whole-life view: "I don't think there's anything wrong with going back over territory you've previously covered." Though avowedly not an (auto-)biographical novelist, Boyd acknowledged that personal experiences often subconsciously affect a writer's fiction. As in several of Boyd's novels there are parallels with the author's life: both Boyd and Mountstuart lived in Africa and France, studied at Oxford, worked in literary London and had a taste of New York. Boyd usually splits the creation of a novel into two phases: research and writing. The first phase of "Any Human Heart" took 30 months as he carefully
Heart failure with preserved ejection fraction atrio-ventricular valves open (mitral valve at left side and tricuspid valve at right side) and the blood passes from the atria into the ventricles. First, ventricles are filled by a pressure gradient but near the end, atria contract (atrial kick) and force more blood to pass into ventricles. Atrial contraction is responsible for around 20% of the total filling blood volume. (In atrial fibrillation, this additional 20% filling volume is lost and the patient may experience systolic heart failure symptoms). Complete left ventricular filling is essential to maintain maximum cardiac output. Left ventricular filling is dependent upon ventricular relaxation and