Glycogen phosphorylase V, McArdle's Disease). More than 65 mutations in the PYGM gene that lead to McArdle disease have been identified to date. Symptoms of McArdle disease include muscle weakness, myalgia, and lack of endurance, all stemming from low glucose levels in muscle tissue. Mutations in the liver isoform of glycogen phosphorylase (PYGL) are associated with Hers' Disease (glycogen storage disease type VI). Hers' disease is often associated with mild symptoms normally limited to hypoglycemia, and is sometimes difficult to diagnose due to residual enzyme activity. The brain isoform of glycogen phosphorylase (PYGB) has been proposed as a biomarker for gastric cancer.
Organ transplantation in fiction Organ transplantation in fiction Organ transplantation is a common theme in science fiction and horror fiction. Numerous horror movies feature the theme of transplanted body parts that are evil or give supernatural powers, with examples including "Body Parts", "Hands of a Stranger", and "The Eye". Organ transplants from donors who are unwilling, or incapable of objecting, to having their organs removed are a recurring theme in dystopian fiction. In contrast to unwilling organ donors, there is the theme of individuals who want to donate their own life-critical organs, such as a brain or heart, at the cost of their own