John Jacob Abel the position of chair of the department until he retired at the age of 75 in 1932. Ever since his early years in Europe, Abel showed great interest in isolating pure form of internal gland hormones. The first work that led to his international reputation as a pharmacologist and biochemist was the isolation of epinephrine from adrenal medulla. However, he was only able to isolate a monobenzoyl derivative of epinephrine. While he was improving his processes on decomposing the benzoyl derivative to obtain salts of epinephrine using saponification, a Japanese chemist J. Takamine, who had visited his lab, was able
John Jacob, Marquess of Montferrat war expenses, John Jacob rebelled; but, after having besieged in Chivasso, he was forced to cease. His state and his prestige were shattered, and he had again to declare himself vassal of Savoy. John Jacob died at Casale Monferrato in 1445, being succeeded by his son John IV. John Jacob married on April 26, 1411 with Joanna of Savoy (1395–1460), daughter of Amadeus VII, Count of Savoy. They had : John Jacob, Marquess of Montferrat John Jacob Palaeologus (Italian: "Giovanni Giacomo Paleologo") (March 23, 1395 – March 12, 1445) was the Margrave of Montferrat from 1418 to 1445. He was