Prunus the skin than in the flesh. They also contain moderate levels of carotenoids and ascorbic acid. Peaches and nectarines are orange and yellow in color which can be attributed to the carotenoids present. Ascorbic acid is important in hydroxylation reactions, such as collagen synthesis and de novo synthesis of bone and cartilage, and wound healing. Ascorbic acid is also a precursor of Vitamin C, which is essential for repairing tissues and absorbing iron. Various "Prunus" species are winter hosts of the Damson-hop aphid, "Phorodon humuli", which is destructive to hops "Humulus lupulus" just at the time of their maturity, so
L-gulonolactone oxidase deficiency living in a malarial infested environment". He based his observation on evidence which indicates that G6PD deficient individuals display enhanced sensitivity to ascorbic acid induced hemolysis. Studies of human diseases have benefited from the availability of small laboratory animal models. However, the tissues of animal models with a GULO gene generally have high levels of ascorbic acid and so are often only slightly influenced by exogenous vitamin C. Guinea pigs, for instance, are a popular human model but lost the ability to synthesize L-gulono-gamma-lactone oxidase 20 million years ago. This is a major handicap for studies involving the endogenous