Ventromedial nucleus of the hypothalamus the brain. VMH is also important in mammal play behaviour. Lesions to VMH along with the hippocampus, amygdala, the cerebellum, and the lateral hypothalamus are all linked to reduced play The VMHdm has a role in the male vocalizations and scent marking behaviors. The VMHvl plays a role in sexual behaviors in females (lordosis), thus stimulating their sexual arousal. Bilateral FOS expression in the VMH after repeated seizures is associated with alteration in the severity of flurothyl induced seizures in C57BL/6J mice that are not present in DBA/2J mice. Moreover, bilateral lesions of the VMH are able to block the
Lateral hypothalamus Lateral hypothalamus The lateral hypothalamus, also called the lateral hypothalamic area, contains the primary orexinergic nucleus within the hypothalamus that widely projects throughout the nervous system; this system of neurons mediates an array of cognitive and physical processes, such as promoting feeding behavior and arousal, reducing pain perception, and regulating body temperature, digestive functions, and blood pressure, among many others. Clinically significant disorders that involve dysfunctions of the orexinergic projection system include narcolepsy, motility disorders or functional gastrointestinal disorders involving visceral hypersensitivity (e.g., irritable bowel syndrome), and eating disorders. The neurotransmitter glutamate and the endocannabinoids (e.g., anandamide) and the orexin