Molecular models of DNA simulations that are very important to understand how DNA functions "in vivo". From the very early stages of structural studies of DNA by X-ray diffraction and biochemical means, molecular models such as the Watson-Crick nucleic acid double helix model were successfully employed to solve the 'puzzle' of DNA structure, and also find how the latter relates to its key functions in living cells. The first high quality X-ray diffraction patterns of A-DNA were reported by Rosalind Franklin and Raymond Gosling in 1953. Rosalind Franklin made the critical observation that DNA exists in two distinct forms, A and B, and produced
Francis Crick of the importance of her experimental results in Watson and Crick's model building and theoretical analysis, Franklin should have had her name on the original Watson and Crick paper in "Nature". Franklin and Gosling submitted their own joint 'second' paper to "Nature" at the same time as Wilkins, Stokes, and Wilson submitted theirs (i.e. the 'third' paper on DNA). Watson's portrayal of Franklin in "The Double Helix" (written after Franklin's death when libel laws did not apply anymore) was negative and gave the appearance that she was Wilkins' assistant and was unable to interpret her own DNA data. The X-ray