Androgen receptor the development and maintenance of the male sexual phenotype. In some cell types, testosterone interacts directly with androgen receptors, whereas, in others, testosterone is converted by 5-alpha-reductase to dihydrotestosterone, an even more potent agonist for androgen receptor activation. Testosterone appears to be the primary androgen receptor-activating hormone in the Wolffian duct, whereas dihydrotestosterone is the main androgenic hormone in the urogenital sinus, urogenital tubercle, and hair follicles. Hence, testosterone is responsible primarily for the development of male primary sexual characteristics, whereas dihydrotestosterone is responsible for secondary male characteristics. Androgens cause slow epiphysis, or maturation of the bones, but more of
Sexual Preference (book) that while Bell "et al."′s suggestion that biological factors have a stronger influence on exclusive homosexuality than they have on bisexuality may seem plausible, it has not been directly tested and appears to conflict with available evidence, such as that concerning prenatal hormone exposure. The psychologist Bruce Rind credited Bell "et al." with disproving psychoanalytic theories about the development of homosexuality, along with the idea that childhood seduction causes homosexuality. The psychologist Mark Yarhouse wrote that while "Sexual Preference" is cited by proponents of a biological explanation, it relies on retrospective memory recall, which can be unreliable. The psychologist J.