Nuclear DNA be advantageous provide the genetic variation upon which natural selection operates to generate new adaptations. Nuclear DNA Nuclear DNA (nDNA), or nuclear deoxyribonucleic acid, is the DNA contained within each cell nucleus of a eukaryotic organism. Nuclear DNA encodes for the majority of the genome in eukaryotes, with mitochondrial DNA and plastid DNA coding for the rest. Nuclear DNA adheres to Mendelian inheritance, with information coming from two parents, one male and one female, rather than matrilineally (through the mother) as in mitochondrial DNA. Nuclear DNA is a nucleic acid, a polymeric biomolecule or biopolymer, found in the nucleus of
DNA polymerase epsilon RPA. PCNA and RFC function as anchor and direct DNA polymerase epsilon onto the DNA template. DNA polymerase epsilon DNA polymerase epsilon is a member of the DNA polymerase family of enzymes found in eukaryotes. It is composed of the following four subunits: POLE (central catalytic unit), POLE2 (subunit 2), POLE3 (subunit 3), and POLE4 (subunit 4). Recent evidence suggests that it plays a major role in leading strand DNA synthesis and nucleotide and base excision repair. Research had conducted to study nucleotide excision repair DNA synthesis by DNA polymerase epsilon in the presence of PCNA (proliferating cell nuclear antigen),