Artificial hair integrations is a type of synthetic fiber that can withstand heat up to 400 °F (200 °C), and can actually outlast human hair. It is very similar to human hair given it is tangle-free and has a natural sheen. It can be straightened or curled, however, it takes longer to set and futura cannot be colored. It is sometimes sold as a human hair blend. The human hair shaft is made up of dead, hard protein, called keratin, in three layers. The inner layer is called the medulla and may not be present. The next layer is the cortex and the
MPLKIP of the hairs. Only a minority of the TTD cases carry a MPLKIP defect: more frequently, the gene ERCC2 is mutated, which encodes a subunit of the protein complex TFIIH that is required for general transcription and for nucleotide excision repair of DNA damage. MPLKIP M-phase-specific PLK1-interacting protein (TTD non-photosensitive 1 protein) is a protein that in humans is encoded by the MPLKIP gene (previously known as C7orf11). Patients with an inherited defect in both alleles of the gene suffer from trichothiodystrophy (TTD), a disease hallmarked by brittle hair and nails and usually by developmental difficulties as well. One patient