Valerian (herb) particular binding site. Hydrophilic extractions of the herb commonly sold over the counter, however, probably do not contain significant amounts of isovaltrate. Valerenic acid in valerian stimulates serotonin receptors as a partial agonist, including 5-HT which is implicated in the sleep-wake cycle. The chief constituent of valerian is a yellowish-green to brownish-yellow oil present in the dried root, varying in content from 0.5 to 2.0%. This variation in quantity may be determined by location; a dry, stony soil yields a root richer in oil than moist, fertile soil. The volatile oils that form the active ingredient are pungent, somewhat reminiscent
Valerian (emperor) the town was besieged by the Persians. At the beginning of 260, Valerian was decisively defeated in the Battle of Edessa, and he arranged a meeting with Shapur to negotiate a peace settlement. The truce was betrayed by Shapur, who seized Valerian and held him prisoner for the remainder of his life. Valerian's capture was a tremendous defeat for the Romans. While fighting the Persians, Valerian sent two letters to the Senate ordering that firm steps be taken against Christians. The first, sent in 257, commanded Christian clergy to perform sacrifices to the Roman gods or face banishment. The second,