Scar healing which heals with a scar. The myofibroblasts make up a high proportion of the fibroblasts proliferating in the postembryonic wound at the onset of healing. In the rat model, for instance, myofibroblasts can constitute up to 70% of the fibroblasts, and is responsible for fibrosis on tissue. Generally, the myofibroblasts disappear from the wound within 30 days, but can stay around in pathological cases in hypertrophy, such as keloids. Myofibroblasts have plasticity and in mice can be transformed into fat cells, instead of scar tissue, via the regeneration of hair follicles. Early and effective treatment of acne scarring can
Treatment of equine lameness of range of motion associated with joint capsule fibrosis. Treatment of joint cartilage injury is difficult and often unrewarding. Partial-thickness defects do not heal. The body will try to repair full-thickness cartilage defects using scar tissue or fibrocartilage, both of which are poor substitutes for normal, healthy articular cartilage. Current treatment includes arthroscopy-produced microfratures within the subchondral plate. These microfractures encourage an inflammatory response within the defect, which recruits stem cells to the area. Unfortunately, these cells differentiate into fibrocartilage, rather than normal joint (hyaline) cartilage, leading to inferior tissue repair at the site of injury. Bone marrow aspirate concentrate