Biomolecular structure chemical probing, hydroxyl radical probing, nucleotide analog interference mapping (NAIM), and in-line probing. Protein and nucleic acid structures can be determined using either nuclear magnetic resonance spectroscopy (NMR) or X-ray crystallography or single-particle cryo electron microscopy (cryoEM). The first published reports for DNA (by Rosalind Franklin and Raymond Gosling in 1953) of A-DNA X-ray diffraction patterns—and also B-DNA—used analyses based on Patterson function transforms that provided only a limited amount of structural information for oriented fibers of DNA isolated from calf thymus. An alternate analysis was then proposed by Wilkins et al. in 1953 for B-DNA X-ray diffraction and scattering
Maurice Wilkins deduced from her X-ray diffraction data. Watson and Crick published their proposed DNA double helical structure in a paper in the journal "Nature" in April 1953. In this paper Watson and Crick acknowledged that they had been "stimulated by... the unpublished results and ideas" of Wilkins and Franklin. The first Watson-Crick paper appeared in "Nature" on 25 April 1953. The members of the Cambridge and King's College laboratories agreed to report their interlocking work in three papers with continuous pagination in "Nature". Sir Lawrence Bragg, the director of the Cavendish Laboratory, where Watson and Crick worked, gave a talk at