History of chemistry 1808, certain of his central ideas were soon adopted by most chemists. However, uncertainty persisted for half a century about how atomic theory was to be configured and applied to concrete situations; chemists in different countries developed several different incompatible atomistic systems. A paper that suggested a way out of this difficult situation was published as early as 1811 by the Italian physicist Amedeo Avogadro (1776-1856), who hypothesized that equal volumes of gases at the same temperature and pressure contain equal numbers of molecules, from which it followed that relative molecular weights of any two gases are the same as
Gas blending total number of all molecules in the mixture. For example, a 50% oxygen, 50% helium mixture will contain approximately the same number of molecules of oxygen and helium. As both oxygen and helium approximate ideal gases at pressures below 200 bar, each will occupy the same volume at the same pressure and temperature, so they can be measured by volume at the same pressure, then mixed, or by partial pressure when decanted into the same container. The mass fraction can be calculated from the molar fraction by multiplying the molar fraction by the molecular mass for each constituent, to find