Human tooth development having negative effects on human health, including, but not limited to, fetal development. As shown in animal studies which mimic human enamel, the mother’s consumption of products with BPA during pregnancy can lead to the child’s tooth development being obstructed. Those children are shown to be prone to incisor and first molar hypomineralization, a weakened state of the enamel. Additionally, it is most important for mother’s to avoid BPA during pregnancy, but also avoid BPA-use in the child’s products up to five months of age. Anodontia is a complete lack of tooth development, and hypodontia is a lack of some
Human tooth development through cementum. NGF-R is present in the condensing ectomesenchymal cells of the dental papilla in the early cap stage tooth germ and plays multiple roles during morphogenetic and cytodifferentiation events in the tooth. There is a relationship between tooth agenesis and absence of the peripheral trigeminal nerve (see Hypodontia). All stages (bud, cap, bell, crown), growth and morphogenesis of the teeth are regulated by a protein called sonic hedgehog. Various phenotypic inputs modulate the size of the teeth. Parathyroid hormone is required for tooth eruption. The following tables present the development timeline of human teeth. Times for the initial calcification