Versican other inflammatory cells) can migrate more easily through extracellular matrix that has a higher versican content. Deposits of versican are not present in normal skin but are found in the reticular dermis during keloid scarring, a condition where scar formation becomes uncontrolled and overgrowth of skin tissue occurs at the site of the wound. Versican has been shown to interact with hyaluronan and a link protein (hyaluronan and proteoglycan link protein 1; HAPLN1). Versican Versican is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the "VCAN" gene. Versican is a
Scar Tissue in a rusty wreck and playing broken instruments on the comeback trail. The video ends after an emotional thirty second Frusciante guitar solo at the moment of sunset, with John tossing the broken guitar from the car. The car Frusciante drove for the video was a 1967 Pontiac Catalina convertible. A very similar concept was considered, then scrapped, for the earlier "Soul to Squeeze" video. Prior to the video shoot, Kiedis had his hair cut and bleached his brown hair to platinum blond. It was filmed in California's Mojave Desert. "Scar Tissue" has been a live staple in the band's