Endocrine gland hormones at target cells "Permissiveness" is the situation in which a hormone cannot exert its full effects without the presence of another hormone. "Synergism" occurs when two or more hormones produce the same effects in a target cell and their results are amplified. "Antagonism" occurs when a hormone opposes or reverses the effect of another hormone. The endocrine glands belong to the body's control system. The hormones which they produce help to regulate the functions of cells and tissues throughout the body. Endocrine organs are activated to release their hormones by humoral, neural or hormonal stimuli. Negative feedback is important
Homeostasis regulating metabolism, reproduction, eating and drinking behaviour, energy utilization, osmolarity and blood pressure. The regulation of metabolism, is carried out by hypothalamic interconnections to other glands. Three endocrine glands of the hypothalamic–pituitary–gonadal axis (HPG axis) often work together and have important regulatory functions. Two other regulatory endocrine axes are the hypothalamic–pituitary–adrenal axis (HPA axis) and the hypothalamic–pituitary–thyroid axis (HPT axis). The liver also has many regulatory functions of the metabolism. An important function is the production and control of bile acids. Too much bile acid can be toxic to cells and its synthesis can be inhibited by activation of FXR