Tetrapod probably had a three-chambered heart, as do modern amphibians and reptiles, in which oxygenated blood from the lungs and de-oxygenated blood from the respiring tissues enters by separate atria, and is directed via a spiral valve to the appropriate vessel — aorta for oxygenated blood and pulmonary vein for deoxygenated blood. The spiral valve is essential to keeping the mixing of the two types of blood to a minimum, enabling the animal to have higher metabolic rates, and be more active than otherwise. The difference in density between air and water causes smells (certain chemical compounds detectable by chemoreceptors) to
Vein and veins; these were later discovered by Marcello Malpighi in 1661. In 1956, André Frédéric Cournand, Werner Forssmann and Dickinson W. Richards were awarded the Nobel Prize in Medicine "for their discoveries concerning heart catheterization and pathological changes in the circulatory system." In his Nobel lecture, Forssmann credits Harvey as birthing cardiology with the publication of his book in 1628. In the 1970s, Diana McSherry developed computer-based systems to create images of the circulatory system and heart without the need for surgery. Vein Veins are blood vessels that carry blood toward the heart. Most veins carry deoxygenated blood from the