Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess syndrome Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder causing hypertension (high blood pressure) and hypokalemia (abnormally low levels of potassium). It was found by Dr Maria I. New at Weil Cornell Hospital in New York City. It results from mutations in the "HSD11B2" gene, which encodes the kidney isozyme of 11β-hydroxysteroid dehydrogenase type 2. In an unaffected individual, this isozyme inactivates circulating cortisol to the less active metabolite cortisone. The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate
Water organ a consonance …. Countless gentlemen could not believe that this organ played by itself, according to the registers, with water, but they rather thought that there was somebody inside'. Besides automatically playing at least three pieces of music, it is now known that the organ was also provided with a keyboard. Other Italian gardens with water organs were at Pratolino, near Florence (c. 1575), Isola de Belvedere, Ferrara (before 1599), Palazzo del Quirinale, Rome (built by Luca Biagi in 1598, restored 1990), Villa Aldobrandini, Frascati (1620), one of the Royal Palaces at Naples (1746), Villa Doria Pamphili, Rome (1758–9). Of