Gonadal dysgenesis If a single or combination of these genes are mutated or deleted, downstream signalling is disrupted, leading to malformation of male external genitalia. SRY acts on gene SOX9 which drives Sertoli cell formation and testis differentiation. An absence in SRY causes SOX9 to not be expressed at the appropriate time or concentration, leading to a deficiency in testosterone and Anti-Müllerian hormone production. Inadequate levels of testosterone and Anti-Müllerian hormone disrupts the development of Wolffian ducts and internal genitalia that are key to male reproductive tract development. The lack of the male associated steroid hormones drives Müllerian duct development and perusal
Causes of sexual violence if they report rape. These risks include being subjected to violence (including honor killings) by their families, being prosecuted for sex outside marriage, or being forced to marry their rapist. This creates a culture of impunity which allows rape to go unpunished. Sexual violence committed by men is to a large extent rooted in ideologies of male sexual entitlement. These belief systems grant women extremely few legitimate options to refuse sexual advances. Some men thus simply exclude the possibility that their sexual advances towards a woman might be rejected or that a woman has the right to make an autonomous