History of chemistry quantum mechanics were able to predict qualitatively some chemical features for biologically relevant molecules, they were, till the end of the 20th century, more a collection of rules, observations, and recipes than rigorous ab initio quantitative methods. This heuristic approach triumphed in 1953 when James Watson and Francis Crick deduced the double helical structure of DNA by constructing models constrained by and informed by the knowledge of the chemistry of the constituent parts and the X-ray diffraction patterns obtained by Rosalind Franklin. This discovery lead to an explosion of research into the biochemistry of life. In the same year, the
Raymond Gosling of x-ray diffraction photography of DNA and obtained at the time the sharpest diffraction images of DNA. Gosling made the X-ray diffraction image of DNA known as "Photograph 51". This work led directly to the 1962 Nobel Prize for Physiology or Medicine being awarded to Francis Crick, James D. Watson and Maurice Wilkins. Gosling was the co-author with Franklin of one of the three DNA double helix papers published in "Nature" in April 1953. His other King's colleagues included Alex Stokes and Herbert Wilson. Gosling briefly remained at King's College following the completion of his thesis in 1954 before lecturing