Biomolecular structure chemical probing, hydroxyl radical probing, nucleotide analog interference mapping (NAIM), and in-line probing. Protein and nucleic acid structures can be determined using either nuclear magnetic resonance spectroscopy (NMR) or X-ray crystallography or single-particle cryo electron microscopy (cryoEM). The first published reports for DNA (by Rosalind Franklin and Raymond Gosling in 1953) of A-DNA X-ray diffraction patterns—and also B-DNA—used analyses based on Patterson function transforms that provided only a limited amount of structural information for oriented fibers of DNA isolated from calf thymus. An alternate analysis was then proposed by Wilkins et al. in 1953 for B-DNA X-ray diffraction and scattering
DNA Tower The glass is held in place by a steel armature that is painted blue. The base support of the sculpture is surrounded and protected by a 5' tall circular cherry wood base that is 5'5" in diameter. "DNA Tower" was commissioned to commemorate both the 100th anniversary of the IU School of Medicine (founded 1903) and the 50th anniversary of the discovery of the structure of the DNA molecule (discovered 1953) by 1950 IU alumnus James D. Watson and his colleague Francis Crick. The glass pieces and painted steel armature were fabricated in Chihuly's Seattle studios. On September 23, 2003,