Exercise physiology loss of integrity to the blood brain barrier. Hyperthermia also can lower cerebral blood flow, and raise brain temperature. Researchers once attributed fatigue to a build-up of lactic acid in muscles. However, this is no longer believed. Rather, lactate may stop muscle fatigue by keeping muscles fully responding to nerve signals. The available oxygen and energy supply, and disturbances of muscle ion homeostasis are the main factor determining exercise performance, at least during brief very intense exercise. Each muscle contraction involves an action potential that activates voltage sensors, and so releases Ca ions from the muscle fibre’s sarcoplasmic reticulum. The
The Supremes Produced and Arranged by Jimmy Webb Lynda Laurence followed when she became pregnant, and Mary Wilson had to assemble a new line-up. All songs produced by Jimmy Webb, except "I Guess I'll Miss the Man" (Sherlie Matthews and Deke Richards). All lead vocals by Jean Terrell except where noted The Supremes Produced and Arranged by Jimmy Webb The Supremes Produced and Arranged by Jimmy Webb is the twenty-sixth studio album released by The Supremes on the Motown label in 1972. It was the only Supremes LP produced (and chiefly written) by a non-Motown artist, successful songwriter and producer Jimmy Webb, and was the last album to