I-motif DNA I-motif DNA i-motif DNA is a type of deoxyribonucleic acid, discovered in 2018, that is found in the nuclei of human cells. An abbreviation of intercalated motif, the four-strand i-motif is unlike the iconic double helix DNA. I-motifs are four-stranded quadruplex structures formed by cytosine-rich DNA, similar to the G-quadruplex structures that guanine-rich DNA forms. C-rich DNA regions are common in gene regulation portions of the genome. Recently, i-motifs were discovered in human cells and were shown to play a role in cell reproduction. I-motifs have potential applications in nanotechnology and nanomedicine due to their unique pH sensitivity and have
Calcium signaling in cell division cell lines, that the G2/M checkpoint is regulated by CaMKII and MAPK crosstalk. Here, CaMKII activates MEK/ERK, which degrades the cell cycle arresting p27 protein In general, transformed cells proliferate in a calcium-independent manner, whereas non-transformed cells show high sensitivity to extra-cellular calcium concentration, suggesting oncogenic growth may include disruption of calcium signaling. Condensation of chromatin is a vital step in cell division, allowing cells to equally distribute chromosomes to the daughter cells. Recent work has suggested that Ca is required for enabling chromatin condensation in prometaphase. Calcium was found to concentrate on condensed DNA to much higher levels compared