Sexual differentiation in humans any androgen can cause external masculinization. The most potent is dihydrotestosterone (DHT), generated from testosterone in skin and genital tissue by the action of 5α-reductase. A male fetus may be incompletely masculinized if this enzyme is deficient. In some diseases and circumstances, other androgens may be present in high enough concentrations to cause partial or (rarely) complete masculinization of the external genitalia of a genetically female fetus. The testes begin to secrete three hormones that influence the male internal and external genitalia. They secrete anti-müllerian hormone, testosterone, and Dihydrotestosterone. anti-Müllerian hormone (AMH) causes the paramesonephric ducts to regress. Testosterone, which
Sexual frustration For males it could be that they have testicles and no penis; a male might be born without a penis (aphallia) or be born with one and have it removed (penis removal or penectomy). Men can still ejaculate via prostate stimulation in that case. For females they might not have a clitoris which causes sexual pleasure; a female might have had her clitoris forcibly severed (female genital mutilation) or voluntarily removed (female circumcusion) as part of a medical procedure. Involuntary celibacy is a form of sexual frustration. Sexual frustration Sexual frustration in humans is frustration caused by a discrepancy between