Oxygen–hemoglobin dissociation curve the fluid that surrounds it. Hemoglobin (Hb) is the primary vehicle for transporting oxygen in the blood. Oxygen is also carried dissolved in the blood's plasma, but to a much lesser degree. Hemoglobin is contained in red blood cells. Under certain conditions, oxygen bound to the hemoglobin is released into the blood's plasma and absorbed into the tissues. Each hemoglobin molecule has the capacity to carry four oxygen molecules. These molecules of oxygen bind to the iron of the Heme group. The binding of the first oxygen molecule induces a conformational change of hemoglobin that increases the affinity for the
Packed red blood cells a health system. In the United Kingdom they cost about 120 pounds per unit. A number of other versions also exist including whole blood, leukocyte reduced red blood cells, and washed red blood cells. More than 100 million units of blood are collected each year around the world, and about 50% of these are given to people in high income countries. In low-income countries, the majority of blood transfusions (up to 65%) are given to children under 5 years of age to treat severe childhood anemia. Another major use of blood in low income countries is to treat pregnancy-related complications.