Hypothalamic–pituitary–thyroid axis and TSH receptor antibodies may be the reason for the observation that the relation between free T4 concentration and TSH levels deviates from a pure loglinear relation that has previously been proposed. Standard procedures cover the determination of serum levels of the following hormones: For special conditions the following assays and procedures may be required: Hypothalamic–pituitary–thyroid axis The hypothalamic–pituitary–thyroid axis (HPT axis for short, a.k.a. thyroid homeostasis or thyrotropic feedback control) is part of the neuroendocrine system responsible for the regulation of metabolism. As its name suggests, it depends upon the hypothalamus, the pituitary gland, and the thyroid gland. The
Pituitary adenoma showed that acromegaly cases with "AIP" mutations occurred about 20 years before acromegaly cases without "AIP" mutations and these tumors are large and relatively treatment resistant. Due to their young age at onset, "AIP" mutations are the most frequent genetic cause of pituitary gigantism (29% of cases). X-LAG is a rare syndrome of very early childhood onset pituitary tumors/hyperplasia that leads to growth hormone excess and severe overgrowth and pituitary gigantism. Three FIPA families with X-LAG have been reported to date all of which had transmission of a chromosome Xq26.3 duplication from affected mother to affected son . The disease