Sexual desire have been associated with a decline in sexual desire. Though it is not used as medication, the drug methamphetamine has a strong positive effect on many aspects of sexual behaviour, including sexual desire. Sexual desire is said to be influenced by androgens in men and by androgens and estrogens in women. Many studies associate the sex hormone, testosterone with sexual desire. Testosterone is mainly synthesized in the testes in men and in the ovaries in women. Another hormone thought to influence sexual desire is oxytocin. Exogenous administration of moderate amounts of oxytocin has been found to stimulate females to desire
Alpha-Melanocyte-stimulating hormone melanotan II, the former of which being in phase-III clinical trials in the United States. Bremelanotide, another analogue of α-MSH, is currently under development not as a photoprotective agent, but instead for the treatment of sexual dysfunction. All of these drugs have significantly greater potencies than α-MSH, along with improved pharmacokinetics and distinctive selectivity profiles. Alpha-Melanocyte-stimulating hormone α-Melanocyte-stimulating hormone (α-MSH) is an endogenous peptide hormone and neuropeptide of the melanocortin family, with a tridecapeptide structure and the amino acid sequence Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH. It is the most important of the melanocyte-stimulating hormones (MSHs) (also known as melanotropins) in stimulating melanogenesis, a process