Glycogen storage disease type 0 glycogen primer. Its action is highly regulated by a mechanism of phosphorylation and dephosphorylation and modulated by counter-regulatory hormones including insulin, epinephrine, and glucagon. Mutations in the gene for liver glycogen synthetase (GYS2, 138571) result in decreased or absent activity of liver glycogen synthetase and moderately decreased amounts of structurally normal glycogen in the liver. Mutational studies of patients with glycogen-storage disease type 0 do not demonstrate correlations between genotype and phenotype. [3] A different gene (GYS1, 138570) encodes muscle glycogen synthetase, which has normal activity in patients with glycogen-storage disease type 0A. In the early stages of fasting, the
Organ transplantation in fiction Organ transplantation in fiction Organ transplantation is a common theme in science fiction and horror fiction. Numerous horror movies feature the theme of transplanted body parts that are evil or give supernatural powers, with examples including "Body Parts", "Hands of a Stranger", and "The Eye". Organ transplants from donors who are unwilling, or incapable of objecting, to having their organs removed are a recurring theme in dystopian fiction. In contrast to unwilling organ donors, there is the theme of individuals who want to donate their own life-critical organs, such as a brain or heart, at the cost of their own