I-motif DNA I-motif DNA i-motif DNA is a type of deoxyribonucleic acid, discovered in 2018, that is found in the nuclei of human cells. An abbreviation of intercalated motif, the four-strand i-motif is unlike the iconic double helix DNA. I-motifs are four-stranded quadruplex structures formed by cytosine-rich DNA, similar to the G-quadruplex structures that guanine-rich DNA forms. C-rich DNA regions are common in gene regulation portions of the genome. Recently, i-motifs were discovered in human cells and were shown to play a role in cell reproduction. I-motifs have potential applications in nanotechnology and nanomedicine due to their unique pH sensitivity and have
DNA laddering along with DNA laddering such as TEM and TUNEL. With recent improvements to DNA laddering, DNA laddering has become a more reliable, and reasonable technique to use when detecting apoptosis. It is also important to note that DNA laddering occurs differently depending on the type of cell, so there may be slight changes in the process of DNA laddering depending on the cell that is being investigated. DNA laddering DNA laddering is a feature that can be observed when DNA fragments, resulting from apoptotic DNA fragmentation, are visualized after separation by gel electrophoresis. It was first described in 1980 by