Antibiotic resistance in gonorrhea mechanism for beta-lactam resistance. There have been over 200 beta-lactamases described and some of them are antibiotic specific. TEM-1 is a penicillinase specific for penicillins. This enzyme will bind to the beta-lactam ring which is a structural characteristic for beta-lactams and hydrolyze the ring. This renders the antibiotic inactive. The spread of the penicillinase resistance was much faster compared to the chromosomal-mediated resistance mechanisms. The plasmids containing TEM-1 could be passed from bacterium to bacterium via conjugation Quinolones are a class of synthetic antibiotics that inhibit DNA replication, recombination, and repair by interacting with the bacterial DNA gyrase and/or topoisomerase
Poverty Discovered as the "Summer Hill Farm" which raises thoroughbred horses for track uses or sale. Neighboring Greenway farms also resides on land once named "Poverty Discovered". In 2012, the resale of the adjacent Woodmont Academy sparked controversy as a high density use of the property next to the historic site. Poverty Discovered Located Cooksville in Howard County, Maryland, United States, Poverty Discovered, "Summer Hill Farm" "Poverty Discovered" is named after the 1737 acre land tract Given to Joseph Hobbs by Lord Calvert in 1760. It was then owned by Captain Thomas Hobbs, who was involved in the burning of the Peggy