John Jacob Abel to successfully isolate the neutral base of epinephrine by adding ammonium to highly concentrated extract, a method Abel himself tried but failed due to the use of low concentration of extract. After Takamine's success, Abel himself remarked, with great candor, "The efforts of years on my part in this once mysterious field of suprarenal, medullary biochemistry, marred by blunders as they were, eventuated, then, in the isolation of the hormone not in the form of the free base but in that of its monobenzoyl derivative." Together with L.G. Rowntree and B.B. Turner, Abel devised what they called a "vividiffusion" apparatus,
Jacob Bernoulli exactly the same time, no matter what the starting point. It had been studied by Huygens in 1687 and Leibniz in 1689. After finding the differential equation, Bernoulli then solved it by what we now call separation of variables. Jacob Bernoulli's paper of 1690 is important for the history of calculus, since the term integral appears for the first time with its integration meaning. In 1696 Bernoulli solved the equation, now called the Bernoulli differential equation, Jacob Bernoulli also discovered a general method to determine evolutes of a curve as the envelope of its circles of curvature. He also investigated