Muscarinic antagonist brain, involving both increased levels of acetylcholine and degeneration of dopaminergic pathways (nigrostriatal pathway). Thus, in parkinsonism there is decreased level of dopaminergic activity. One method of balancing the neurotransmitters is through blocking central cholinergic activity using muscarinic receptor antagonists. Atropine acts on the M2 receptors of the heart and antagonizes the activity of acetylcholine. It causes tachycardia by blocking vagal effects on the sinoatrial node. Acetylcholine hyperpolarizes the sinoatrial node, which is overcome by MRA and thus increases the heart rate. If atropine is given by intramuscular or subcutaneous injection, it causes initial bradycardia. This is because by i.m/s.c
Node graph architecture Node graph architecture Node graph architecture is a type of software design which builds around modular node components which can be connected to form a graph. Often the software's underlying node graph architecture is also exposed to the end user as a two-dimensional visualization of the node graph. The node graph architecture is popular in the film and computer games industry. There are often many different node types participating in the node graph. For example, in the Nuke Manual they list hundreds of nodes. Each node type performs one specific task. For example, Nuke's Merge node produces an output image