Molecular models of DNA simulations that are very important to understand how DNA functions "in vivo". From the very early stages of structural studies of DNA by X-ray diffraction and biochemical means, molecular models such as the Watson-Crick nucleic acid double helix model were successfully employed to solve the 'puzzle' of DNA structure, and also find how the latter relates to its key functions in living cells. The first high quality X-ray diffraction patterns of A-DNA were reported by Rosalind Franklin and Raymond Gosling in 1953. Rosalind Franklin made the critical observation that DNA exists in two distinct forms, A and B, and produced
Maurice Wilkins deduced from her X-ray diffraction data. Watson and Crick published their proposed DNA double helical structure in a paper in the journal "Nature" in April 1953. In this paper Watson and Crick acknowledged that they had been "stimulated by... the unpublished results and ideas" of Wilkins and Franklin. The first Watson-Crick paper appeared in "Nature" on 25 April 1953. The members of the Cambridge and King's College laboratories agreed to report their interlocking work in three papers with continuous pagination in "Nature". Sir Lawrence Bragg, the director of the Cavendish Laboratory, where Watson and Crick worked, gave a talk at