Ameloblast showing a disruption in enamel production when the person is born. High fevers in childhood are also an example of bodily stressors causing interruptions in enamel production. Another possible example of this sensitivity (stress response pathway activation) may be the development of dental fluorosis after childhood exposure (between the ages of 2 to 8 years old) to excess fluoride, an elemental agent used to increase enamel hardness and prevent dental caries. Ameloblast Ameloblasts are cells present only during tooth development that deposit tooth enamel, which is the hard outermost layer of the tooth forming the surface of the crown. Each
Human tooth development rapidly. This results in the perpetually increasing size of the junctional epithelial layer and the isolation of the remnants of ameloblasts from any source of nutrition. As the ameloblasts degenerate, a gingival sulcus is created. Frequently, nerves and blood vessels run parallel to each other in the body, and the formation of both usually takes place simultaneously and in a similar fashion. However, this is not the case for nerves and blood vessels around the tooth, because of different rates of development. Nerve fibers start to near the tooth during the cap stage of tooth development and grow toward the