John Jacob Abel the position of chair of the department until he retired at the age of 75 in 1932. Ever since his early years in Europe, Abel showed great interest in isolating pure form of internal gland hormones. The first work that led to his international reputation as a pharmacologist and biochemist was the isolation of epinephrine from adrenal medulla. However, he was only able to isolate a monobenzoyl derivative of epinephrine. While he was improving his processes on decomposing the benzoyl derivative to obtain salts of epinephrine using saponification, a Japanese chemist J. Takamine, who had visited his lab, was able
Adrenocortical hormone darkening the skin tone. The standard treatment for Addison’s disease is hormone replacement therapy for the mineralocorticoids and glucocorticoids that are no longer able to be synthesized.[12] Former U.S. President John F. Kennedy is a well-known individual who suffered from Addison’s disease throughout his presidency. Due to the availability of hormone replacement therapy, he and his staff were able to cover up his condition. Recent studies have discovered a pathway that links stress to the onset of disease through the activation of certain genes. The experience of psychological stress activates transcription factors that activate genes. In a study by Cole