Nucleated red blood cell in the normal development of a normoblast. A megaloblast is an unusually large erythroblast that can be associated with vitamin B deficiency (caused by pernicious anemia or dietary insufficiency), folic acid deficiency, or both (such anemias are collectively called megaloblastic anemias). This kind of anemia leads to macrocytes (abnormally large red cells) and the condition called macrocytosis. The cause of this cellular gigantism is an impairment in DNA replication that delays nuclear maturation and cell division. Because RNA and cytoplasmic elements are synthesized at a constant rate despite the cells' impaired DNA synthesis, the cells show nuclear-cytoplasmic asynchrony. NRB's can
Red as Blood, or Tales from the Sisters Grimmer Red as Blood, or Tales from the Sisters Grimmer Red as Blood, or Tales from the Sisters Grimmer is a short story collection of dark fantasy retellings of popular fairytales by British author Tanith Lee. Contrary to what the title may suggest, it not only includes retellings of fairytales by the Brothers Grimm, but also by Charles Perrault, Gabrielle-Suzanne Barbot de Villeneuve or Alexander Afanasyev. The title story was nominated for a Nebula Award. "Red as Blood, or Tales from the Sisters Grimmer" contains the following tales: In 2014, the book was released as an expanded edition including a new