Light effects on circadian rhythm collected by rod cells and cone cells and the retinal ganglion cells (RGCs), or it is directly collected by these RGCs. The RGCs use the photopigment melanopsin to absorb the light energy. Specifically, this class of RGCs being discussed is referred to as "intrinsically photosensitive," which just means they are sensitive to light. There are five known types of intrinsically photosensitive retinal ganglion cells (ipRGCs): M1, M2, M3, M4, and M5. Each of these differently ipRGC types have different melanopsin content and photosensitivity. These connect to amacrine cells in the inner plexiform layer of the retina. Ultimately, via this retinohypothalamic
Laser safety near-infrared light onto the retina. A laser beam can be focused to an intensity on the retina which may be up to 200,000 times higher than at the point where the laser beam enters the eye. Most of the light is absorbed by melanin pigments in the pigment epithelium just behind the photoreceptors, and causes burns in the retina. Ultraviolet light with wavelengths shorter than 400 nm tends to be absorbed by lens and 300 nm in the cornea, where it can produce injuries at relatively low powers due to photochemical damage. Infrared light mainly causes thermal damage to the