History of genetics code for specific proteins, leading to the "one gene, one enzyme" hypothesis. Oswald Avery, Colin Munro MacLeod, and Maclyn McCarty showed in 1944 that DNA holds the gene's information. In 1952, Rosalind Franklin and Raymond Gosling produced a strikingly clear x-ray diffraction pattern indicating a helical form, and in 1953, James D. Watson and Francis Crick demonstrated the molecular structure of DNA. Together, these discoveries established the central dogma of molecular biology, which states that proteins are translated from RNA which is transcribed by DNA. This dogma has since been shown to have exceptions, such as reverse transcription in retroviruses.
Francis Crick diffraction images collected by Franklin provided the best evidence for the helical nature of DNA. While Franklin's experimental work proved important to Crick and Watson's development of a correct model, she herself could not realize it at the time. When she left King's College, Director Sir John Randall insisted that all DNA work belonged exclusively to King's and ordered Franklin to not even think about it. Franklin subsequently did superb work in J. D. Bernal's Lab at Birkbeck College with the tobacco mosaic virus extending ideas on helical construction. Crick was often described as very talkative, with Watson – in