Pearl or parasite enters a bivalve mollusk and settles inside the shell. The mollusk, irritated by the intruder, forms a pearl sac of external mantle tissue cells and secretes the calcium carbonate and conchiolin to cover the irritant. This secretion process is repeated many times, thus producing a pearl. Natural pearls come in many shapes, with perfectly round ones being comparatively rare. Typically, the build-up of a natural pearl consists of a brown central zone formed by columnar calcium carbonate (usually calcite, sometimes columnar aragonite) and a yellowish to white outer zone consisting of nacre (tabular aragonite). In a pearl cross-section
Pearl extensive and successful use of the Biwa Pearl Mussel is reflected in the name "Biwa pearls", a phrase which was at one time nearly synonymous with freshwater pearls in general. Since the time of peak production in 1971, when Biwa pearl farmers produced six tons of cultured pearls, pollution has caused the virtual extinction of the industry. Japanese pearl farmers recently cultured a hybrid pearl mussel – a cross between Biwa Pearl Mussels and a closely related species from China, "Hyriopsis cumingi", in Lake Kasumigaura. This industry has also nearly ceased production, due to pollution. Japanese pearl producers also invested