Gene therapy of the human retina levels of light. What follows often is the death of cone cells, responsible for color vision and acuity, at light levels present during the day. Loss of cones leads to full blindness as early as five years old, but may not onset until many years later. There have been multiple hypotheses about how the lack of rod cells can lead to the death of cone cells. Pinpointing a mechanism for RP is difficult because there are more than 39 genetic loci and genes correlated with this disease. In an effort to find the cause of RP, there have been different
Retina the retina, which in its entirety comprises ten distinct layers, including an outer layer of pigmented epithelial cells. The only neural cells that are directly sensitive to light are the photoreceptor cells, which are of two types: rods and cones. Rods function mainly in dim light and provide black-and-white vision while cones are responsible for the perception of colour. A third type of photoreceptor, the photosensitive ganglion cells, is important for entrainment and reflexive responses to the brightness of light. Light striking the retina initiates a cascade of chemical and electrical events that ultimately trigger nerve impulses that are sent