John Jacob Abel to successfully isolate the neutral base of epinephrine by adding ammonium to highly concentrated extract, a method Abel himself tried but failed due to the use of low concentration of extract. After Takamine's success, Abel himself remarked, with great candor, "The efforts of years on my part in this once mysterious field of suprarenal, medullary biochemistry, marred by blunders as they were, eventuated, then, in the isolation of the hormone not in the form of the free base but in that of its monobenzoyl derivative." Together with L.G. Rowntree and B.B. Turner, Abel devised what they called a "vividiffusion" apparatus,
Melanin-concentrating hormone as part of the immune response. More research is needed to fully determine and understand any relationship between MCH and possible immune responses in skin. MCH was initially discovered in the teleost fish; it was found to help determine the fish's skin color. Later, a mammalian version of MCH was discovered in rats, where most of the functions and localizations are conserved across mammalian species. Melanin-concentrating hormone Melanin-concentrating hormone (MCH) is a cyclic 19-amino acid orexigenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish, where it controls skin pigmentation. In mammals it is involved in the regulation