Effect of spaceflight on the human body of muscle fibre prominent in muscles also change. Slow twitch endurance fibres used to maintain posture are replaced by fast twitch rapidly contracting fibres that are insufficient for any heavy labour. Advances in research on exercise, hormone supplements and medication may help maintain muscle and body mass. Bone metabolism also changes. Normally, bone is laid down in the direction of mechanical stress. However, in a microgravity environment there is very little mechanical stress. This results in a loss of bone tissue approximately 1.5% per month especially from the lower vertebrae, hip and femur. Due to microgravity and the decreased load
The Biggest Loser males tend to weigh over or near 300 lb (136 kg). Females tend to weigh over or near 200 lb (91 kg). In addition to individual contestants, some seasons in some international adaptations have featured couples or even whole families. <section begin="Whole series"/> <section end="Whole series"/> Jodie Prenger from series 2 of the UK version was the first female biggest loser worldwide, losing 46.85% of her original body weight. The Biggest Loser RunWalk is the official race series of "The Biggest Loser". Dan and Jackie Evans from Season Five are the national spokespeople. "The Biggest Loser" is a video game