I-motif DNA I-motif DNA i-motif DNA is a type of deoxyribonucleic acid, discovered in 2018, that is found in the nuclei of human cells. An abbreviation of intercalated motif, the four-strand i-motif is unlike the iconic double helix DNA. I-motifs are four-stranded quadruplex structures formed by cytosine-rich DNA, similar to the G-quadruplex structures that guanine-rich DNA forms. C-rich DNA regions are common in gene regulation portions of the genome. Recently, i-motifs were discovered in human cells and were shown to play a role in cell reproduction. I-motifs have potential applications in nanotechnology and nanomedicine due to their unique pH sensitivity and have
Pfu DNA polymerase and (1991)Patent 5,545,552 over "Pfu" itself was granted in August 1996. Pfu DNA polymerase "Pfu" DNA polymerase is an enzyme found in the hyperthermophilic archaeon "Pyrococcus furiosus", where it functions to copy the organism's DNA during cell division. In the laboratory setting, "Pfu" is used to amplify DNA in the polymerase chain reaction (PCR), where the enzyme serves the central function of copying a new strand of DNA during each extension step. "Pfu" DNA polymerase has superior thermostability and proofreading properties compared to "Taq" DNA polymerase. Unlike "Taq" DNA polymerase, "Pfu" DNA polymerase possesses 3' to 5' exonuclease proofreading activity,