Mackenzie River from the Peace-Athabasca system are significantly slowed by the delta area at the western end of Lake Athabasca causing the lake to rise, and the excess water can only flow out after the rivers have receded. The same phenomenon occurs at Great Slave Lake, which naturally regulates the flow from the Slave River into the Mackenzie. There are river gages at several upstream points along the Mackenzie River. The average flow rate at the outlet of Great Slave Lake is . At Fort Simpson, below the Liard River, it is . At Norman Wells it is , and at the
Lake Athabasca depth of , and holds of water, making it the largest and deepest lake in both Alberta and Saskatchewan, and the eighth largest in Canada. Water flows northward from the lake via the Slave River and Mackenzie River systems, eventually reaching the Arctic Ocean. Fort Chipewyan, one of the oldest European settlements in Alberta, is located on the western shore of the lake, where the Rivière des Rochers drains the lake and flows toward Slave River, beginning its northward journey along the eastern boundary of Wood Buffalo National Park. The eastern section of the lake narrows to a width of