Horn River formed along the middle course of the Horn River, and is followed downstream by the "Second Lake". The river turns south-west, where the "Mink Lake" is formed along its course. The Laferte River also flows into the Mink Lake. Horn River then flows south, and it receives the waters of the Bluefish River before it empties into the Mackenzie River, downstream from the Great Slave Lake), immediately upstream from Mills Lake, at an elevation of . The arch made by the river defines the "Horn Plateau", a flat elevated area that rises up to ) to the north and east,
Mackenzie River watershed drains about 20 percent of Canada. It is the largest river flowing into the Arctic from North America, and including its tributaries has a total length of , making it the thirteenth longest river system in the world. Through its many tributaries, the Mackenzie River basin covers portions of five Canadian provinces and territories – British Columbia (BC), Alberta, Saskatchewan, Yukon, and Northwest Territories. Thutade Lake, in the Northern Interior of BC, is the ultimate source of the Mackenzie River via the Finlay–Peace River system, which stretches through BC and Alberta. The Athabasca River originates further south, in Jasper