Oak Ridge National Laboratory was completed, later renamed to "Oak Ridge National Laboratory". The site was chosen for the X-10 Graphite Reactor, used to show that plutonium can be created from enriched uranium. Enrico Fermi and his colleagues developed the world's second self-sustaining nuclear reactor after Fermi's previous experiment, the Chicago Pile-1. The X-10 was the first reactor designed for continuous operation. After the end of World War II the demand for weapons-grade plutonium fell and the reactor and the laboratory's 1000 employees were no longer involved in nuclear weapons. Instead, it was used for scientific research. In 1946 the first medical isotopes were
Enrico Fermi a much larger scale. Fermi and Szilárd collaborated on a design of a device to achieve a self-sustaining nuclear reaction—a nuclear reactor. Owing to the rate of absorption of neutrons by the hydrogen in water, it was unlikely that a self-sustaining reaction could be achieved with natural uranium and water as a neutron moderator. Fermi suggested, based on his work with neutrons, that the reaction could be achieved with uranium oxide blocks and graphite as a moderator instead of water. This would reduce the neutron capture rate, and in theory make a self-sustaining chain reaction possible. Szilárd came up with