Oak Ridge National Laboratory was completed, later renamed to "Oak Ridge National Laboratory". The site was chosen for the X-10 Graphite Reactor, used to show that plutonium can be created from enriched uranium. Enrico Fermi and his colleagues developed the world's second self-sustaining nuclear reactor after Fermi's previous experiment, the Chicago Pile-1. The X-10 was the first reactor designed for continuous operation. After the end of World War II the demand for weapons-grade plutonium fell and the reactor and the laboratory's 1000 employees were no longer involved in nuclear weapons. Instead, it was used for scientific research. In 1946 the first medical isotopes were
Enrico Fermi of Einstein Relativity" by August Kopff in 1923, Fermi was the first to point out that hidden inside the famous Einstein equation () was an enormous amount of nuclear potential energy to be exploited. "It does not seem possible, at least in the near future", he wrote, "to find a way to release these dreadful amounts of energy—which is all to the good because the first effect of an explosion of such a dreadful amount of energy would be to smash into smithereens the physicist who had the misfortune to find a way to do it." In 1924 Fermi was