Nuclear chain reaction the last one called ""Perfectionnement aux charges explosives"" was the first patent for the atomic bomb and is filed as patent n°445686 by the Caisse nationale de Recherche Scientifique. In parallel, Szilárd and Enrico Fermi in New York made the same analysis. This discovery prompted the letter from Szilárd and signed by Albert Einstein to President Franklin D. Roosevelt, warning of the possibility that Nazi Germany might be attempting to build an atomic bomb. On December 2, 1942, a team led by Enrico Fermi produced the first artificial self-sustaining nuclear chain reaction with the Chicago Pile-1 (CP-1) experimental reactor in
Enrico Fermi of Einstein Relativity" by August Kopff in 1923, Fermi was the first to point out that hidden inside the famous Einstein equation () was an enormous amount of nuclear potential energy to be exploited. "It does not seem possible, at least in the near future", he wrote, "to find a way to release these dreadful amounts of energy—which is all to the good because the first effect of an explosion of such a dreadful amount of energy would be to smash into smithereens the physicist who had the misfortune to find a way to do it." In 1924 Fermi was