Horn River formed along the middle course of the Horn River, and is followed downstream by the "Second Lake". The river turns south-west, where the "Mink Lake" is formed along its course. The Laferte River also flows into the Mink Lake. Horn River then flows south, and it receives the waters of the Bluefish River before it empties into the Mackenzie River, downstream from the Great Slave Lake), immediately upstream from Mills Lake, at an elevation of . The arch made by the river defines the "Horn Plateau", a flat elevated area that rises up to ) to the north and east,
Mackenzie River Ocean on 14 July 1789. The river he named "Disappointment River" would later be renamed in his honor. No European reached its mouth again until Sir John Franklin on 16 August 1825. The following year he traced the coast west until blocked by ice while John Richardson followed the coast east to the Coppermine River. In 1849 William Pullen reached the Mackenzie from the Bering Strait. In the following decades the North West Company established forts on the river, the precursors of present-day settlements such as Fort Simpson (formerly Fort of the Forks). A lucrative fur trade was carried out,