Nuclear chain reaction the last one called ""Perfectionnement aux charges explosives"" was the first patent for the atomic bomb and is filed as patent n°445686 by the Caisse nationale de Recherche Scientifique. In parallel, Szilárd and Enrico Fermi in New York made the same analysis. This discovery prompted the letter from Szilárd and signed by Albert Einstein to President Franklin D. Roosevelt, warning of the possibility that Nazi Germany might be attempting to build an atomic bomb. On December 2, 1942, a team led by Enrico Fermi produced the first artificial self-sustaining nuclear chain reaction with the Chicago Pile-1 (CP-1) experimental reactor in
Enrico Fermi down once more a few hours later. The problem was traced to neutron poisoning from xenon-135, a fission product with a half-life of 9.2 hours. DuPont had deviated from the Metallurgical Laboratory's original design in which the reactor had 1,500 tubes arranged in a circle, and had added 504 tubes to fill in the corners. The scientists had originally considered this over-engineering a waste of time and money, but Fermi realized that if all 2,004 tubes were loaded, the reactor could reach the required power level and efficiently produce plutonium. In mid-1944, Robert Oppenheimer persuaded Fermi to join his Project