Athabasca River is marked by rapids, impeding navigation southwest of Fort McMurray. The Athabasca River travels before draining into the Peace-Athabasca Delta near Lake Athabasca south of Fort Chipewyan. From there, its waters flow north as Rivière des Rochers, then joining the Peace River to form the Slave River that empties into Great Slave Lake and discharges through the Mackenzie River system into the Arctic Ocean. The cumulative drainage area is . Numerous communities are located on the banks of the Athabasca River, including Jasper, Brule, Entrance, Hinton, Whitecourt, Fort Assiniboine, Smith, Athabasca, Fort McMurray, and Fort McKay. An independent study has
Mackenzie River and riparian habitat. There are 53 fish species in the basin, none of them endemic. The Mackenzie River has a similar range of fish fauna to the Mississippi River system. It is believed that the two river systems were connected during the Ice Ages by meltwater lakes and channels, allowing fish in the two rivers to interbreed. Fish in the Mackenzie River proper include the northern pike, several minnow species, and lake whitefish. Fish in the southern half of the watershed are genetically isolated from those of the northern half due to large rapids on the Slave River preventing fish