Mackenzie River from the Peace-Athabasca system are significantly slowed by the delta area at the western end of Lake Athabasca causing the lake to rise, and the excess water can only flow out after the rivers have receded. The same phenomenon occurs at Great Slave Lake, which naturally regulates the flow from the Slave River into the Mackenzie. There are river gages at several upstream points along the Mackenzie River. The average flow rate at the outlet of Great Slave Lake is . At Fort Simpson, below the Liard River, it is . At Norman Wells it is , and at the
Mackenzie River north towards the Arctic. It flows through open taiga with its wide valley bounded, on the west, by the Mackenzie Mountains and to the east by low hills of the Canadian Shield. This mostly uninhabited area is called the Mackenzie Lowlands; although partly forested, it is mostly covered by large areas of muskeg, swamps and many small lakes. A number of major tributaries join from the west, including the Root River, Redstone River and Keele River. Below the Keele River, the Mackenzie River flows north along the western base of the Franklin Mountains before turning northwest, and receives the Great