Beer in San Diego County, California the alternative being imported beer from Mexico. But changes in national and state law in the late 1970s made home brewing legal, and in 1982 California allowed breweries to operate restaurants on their premises, which made brewpubs possible. In 1989 the Karl Strauss Brewing Company opened a brewery and brewpub on Columbia Street in Downtown San Diego and expanded into distribution brewing in 1991. This was the first commercial brewery in San Diego since 1953, and for many San Diego consumers it was their first exposure to freshly brewed beer and to styles such as amber lager and pale ale.
University of California, San Diego Medical Center, Hillcrest and Jacobs Medical Center. The university operates 19 organized research units (ORUs), including the Center for Energy Research, Qualcomm Institute (a branch of the California Institute for Telecommunications and Information Technology), San Diego Supercomputer Center and the Kavli Institute for Brain and Mind, as well as eight School of Medicine research units, six research centers at Scripps Institution of Oceanography and two multi-campus initiatives, including the Institute on Global Conflict and Cooperation. UC San Diego is also closely affiliated with several regional research centers, such as the Salk Institute, the Sanford Burnham Prebys Medical Discovery Institute, the