Jim Fixx Jim Fixx James Fuller "Jim" Fixx (April 23, 1932 – July 20, 1984) was an American who wrote the 1977 best-selling book "The Complete Book of Running". He is credited with helping start America's fitness revolution, popularizing the sport of running and demonstrating the health benefits of regular jogging. He died of a heart attack while jogging at 52 years of age. His genetic predisposition for heart problems and other previous lifestyle factors may have caused his heart attack. Born in New York City, Fixx was a graduate of Trinity School in New York and Oberlin College in Ohio. His
Promoter activity and the downstream core promoter element (DPE). Promoters in eukaryotes contain one or more of these core promotes elements (but any of them are absolutely essential for promoter function), these elements are binding sites for subunits of the transcriptional machinery and are involve in the initiation of the transcription, but also they have some specific enhancer functions. In addition, the promoter activity in eukaryotes include some complexities in the way of how they integrate signals from distal factors with the core promoter. Unlike in protein coding regions, where the assumption of sequence conservation of functionally homologous genes have been frequently