The Nutty Professor (1996 film) spawned a sequel, "", which was released in 2000. The film was re-released on Blu-ray combo pack on March 6, 2012, to celebrate the 100th anniversary of Universal Studios. At Wellman College, thousands of hamsters overrun the campus after being accidentally released by Sherman Klump, a morbidly obese but very kind-hearted professor. Meanwhile, Sherman has created an experimental formula that reconstructs the DNA of an obese person in a way that allows them to lose weight more easily. After his lecture, Sherman meets and instantly falls in love with Carla Purty, a chemistry graduate who is a big fan of
Nutty Professor II: The Klumps firm. Meanwhile, a worried Denise discovers what has happened and that Sherman's brain damage has progressed to almost eighty percent. Enlisting the help of Sherman's father Cletus, Denise goes after him. Sherman takes advantage of the canine DNA that crossed with Buddy's, and uses the tennis ball to play fetch. The ball is covered with the new formula, which takes Buddy back to an infantile state and eventually to a glowing mass of genetic material for Sherman to suck the genetic material back into his body through a straw, thus putting his DNA back together and returning him to normal.