The Nutty Professor (character) recently fallen in love with grad student and chemistry teacher Carla Purty (Jada Pinkett Smith), Klump uses his latest discovery, a weight-loss serum that rewrites the subject's genes, to lose weight in order to spend time with her. Unfortunately, this serum creates the confident but mean-spirited individual known as Buddy Love, due to the testosterone imbalance caused by the transformation causing Buddy to manifest as an independent personality. When Klump's student and assistant Jason learns what has happened, he realizes that Buddy is gaining increasingly greater freedom from the professor's influence. This encourages Klump to take back control of his
The Perfect Drug audio release of it in North America being on the "Lost Highway" soundtrack. A music video for it was directed by Mark Romanek, included with "Closure", a VHS compilation and "". In 2002, American post-hardcore band the Blood Brothers sampled the song in their song "Kiss of the Octopus". In 2011, the song was used as the entrance song for Japanese mixed martial artist Michihiro Omigawa at UFC 131. American deathcore band Fit for an Autopsy covered the song for the split EP "The Depression Sessions" in 2016. Despite being a single, "The Perfect Drug" did not appear live until