The Nutty Professor (1996 film) spawned a sequel, "", which was released in 2000. The film was re-released on Blu-ray combo pack on March 6, 2012, to celebrate the 100th anniversary of Universal Studios. At Wellman College, thousands of hamsters overrun the campus after being accidentally released by Sherman Klump, a morbidly obese but very kind-hearted professor. Meanwhile, Sherman has created an experimental formula that reconstructs the DNA of an obese person in a way that allows them to lose weight more easily. After his lecture, Sherman meets and instantly falls in love with Carla Purty, a chemistry graduate who is a big fan of
The Perfect Drug audio release of it in North America being on the "Lost Highway" soundtrack. A music video for it was directed by Mark Romanek, included with "Closure", a VHS compilation and "". In 2002, American post-hardcore band the Blood Brothers sampled the song in their song "Kiss of the Octopus". In 2011, the song was used as the entrance song for Japanese mixed martial artist Michihiro Omigawa at UFC 131. American deathcore band Fit for an Autopsy covered the song for the split EP "The Depression Sessions" in 2016. Despite being a single, "The Perfect Drug" did not appear live until