International Space Station program out of 28 flights have not been to the ISS, and only the planned Hubble Space Telescope servicing mission in 2009 will not be ISS-related out of 13 planned missions until the end of the Space Shuttle program in 2010). The Space Shuttle was retired from service upon the conclusion of Atlantis' final flight on July 21, 2011. NASA was reliant even at the time on some of the resupply contracts being fielded out to Soyuz and Progress and the other unmanned tugs, but it had launched a few years earlier into a program of aggressive development of commercial US
Space Shuttle program and were formally initiated in 1983 by President Ronald Reagan, but the ISS suffered from long delays, design changes and cost over-runs and forced the service life of the Space Shuttle to be extended several times until 2011 when it was finally retired—serving twice as long than it was originally designed to do. In 2004, according to President George W. Bush's Vision for Space Exploration, use of the Space Shuttle was to be focused almost exclusively on completing assembly of the ISS, which was far behind schedule at that point. The first experimental orbiter "Enterprise" was a high-altitude glider, launched