Untamed Heart agent, MGM had greenlighted the project. Originally, the film was titled "The Baboon Heart" in honor of an infant named Baby Fae (born 14 October 1984) who received a cross-species heart transplant from a baboon to fix a congenital heart defect. Initially, Bill had not considered Christian Slater for the role of Adam, “but then it was just the obvious choice." For the role of Caroline, Bill remembered auditioning Marisa Tomei for his earlier film, "Five Corners". While she had been too young for that role, after her success with "My Cousin Vinny" he felt she was right for the
Baboon syndrome Baboon syndrome Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), more popularly known as Baboon syndrome because of its resemblance to the distinctive red buttocks displayed by female baboons, is a systemic contact dermatitis characterized by well-demarcated patches of erythema distributed symmetrically on the buttocks. The cause of the syndrome may be drug-related, i.e. induced by systemic administration of hydroxyzine penicillin, iodinated radio contrast media and others. The typical rash commonly appears on buttocks. This then resembles the colour of a baboon’s buttocks. Other areas like upper inner thigh and armpits, may be affected by the rash. The rashes are red