International Space Station program out of 28 flights have not been to the ISS, and only the planned Hubble Space Telescope servicing mission in 2009 will not be ISS-related out of 13 planned missions until the end of the Space Shuttle program in 2010). The Space Shuttle was retired from service upon the conclusion of Atlantis' final flight on July 21, 2011. NASA was reliant even at the time on some of the resupply contracts being fielded out to Soyuz and Progress and the other unmanned tugs, but it had launched a few years earlier into a program of aggressive development of commercial US
Space Shuttle Discovery alone. "Discovery" flew all three "return to flight" missions after the "Challenger" and "Columbia" disasters: STS-26 in 1988, STS-114 in 2005, and STS-121 in 2006. "Discovery" flew the ante-penultimate mission of the Space Shuttle program, STS-133, having launched on February 24, 2011. "Endeavour" flew STS-134 and "Atlantis" performed STS-135, NASA's last Space Shuttle mission. On February 24, 2011, Space Shuttle "Discovery" launched from Kennedy Space Center's Launch Complex 39-A to begin its final orbital flight. The Flow Director was responsible for the overall preparation of the shuttle for launch and processing it after landing, and remained permanently assigned to head