Polio vaccine in several other African nations without necessary information, which epidemiologists believe is due to refusals by certain local populations to allow their children to receive the polio vaccine. The Salk vaccine, IPV, is based on three wild, virulent reference strains, Mahoney (type 1 poliovirus), MEF-1 (type 2 poliovirus), and Saukett (type 3 poliovirus), grown in a type of monkey kidney tissue culture (Vero cell line), which are then inactivated with formalin. The injected Salk vaccine confers IgG-mediated immunity in the bloodstream, which prevents polio infection from progressing to viremia and protects the motor neurons, thus eliminating the risk of bulbar
Vaccine: The Controversial Story of Medicine's Greatest Lifesaver possess the virus. It then describes how this vaccine was only slightly different from the type invented by Edward Jenner two centuries earlier, which was so successful that smallpox became the first and only disease to ever be eradicated. Vaccine developers profiled in the book include Jonas Salk (p. 188) and Maurice Hilleman (p. 238). Allen, later in the book, describes the controversy over vaccines and autism and the founding of SafeMinds, writing, "The vaccines-cause-autism mindset was the product of a set of assumptions that were impossible to completely prove or disprove." (p. 374) It also discusses how preliminary study