The Nutty Professor (character) recently fallen in love with grad student and chemistry teacher Carla Purty (Jada Pinkett Smith), Klump uses his latest discovery, a weight-loss serum that rewrites the subject's genes, to lose weight in order to spend time with her. Unfortunately, this serum creates the confident but mean-spirited individual known as Buddy Love, due to the testosterone imbalance caused by the transformation causing Buddy to manifest as an independent personality. When Klump's student and assistant Jason learns what has happened, he realizes that Buddy is gaining increasingly greater freedom from the professor's influence. This encourages Klump to take back control of his
Nutty Professor II: The Klumps firm. Meanwhile, a worried Denise discovers what has happened and that Sherman's brain damage has progressed to almost eighty percent. Enlisting the help of Sherman's father Cletus, Denise goes after him. Sherman takes advantage of the canine DNA that crossed with Buddy's, and uses the tennis ball to play fetch. The ball is covered with the new formula, which takes Buddy back to an infantile state and eventually to a glowing mass of genetic material for Sherman to suck the genetic material back into his body through a straw, thus putting his DNA back together and returning him to normal.