Model organism anticonvulsant properties of lithium salts, which revolutionized the treatment of bipolar disorder, replacing the previous treatments of lobotomy or electroconvulsive therapy. Modern general anaesthetics, such as halothane and related compounds, were also developed through studies on model organisms, and are necessary for modern, complex surgical operations. In the 1940s, Jonas Salk used rhesus monkey studies to isolate the most virulent forms of the polio virus, which led to his creation of a polio vaccine. The vaccine, which was made publicly available in 1955, reduced the incidence of polio 15-fold in the United States over the following five years. Albert Sabin
Cold War tensions and the polio vaccine flew to Leningrad in June, 1956. As a result of a cooperation of Sabin and Chumakov in Leningrad, Sabin was able to test his attenuated vaccine when funding in America was declined. While Sabin was working behind the Iron Curtain, the Sabin-Chumakov vaccine was determined to be safe and effective. Cold War tensions caused Western scientists to refuse the reports from the Russians about the effectiveness of the Sabin vaccine. However, mass vaccinations of Sabin's vaccine spread throughout Eastern Europe from 1960–1963. Just as some Soviet virologists did not trust the Western Salk vaccine, Americans had similar reservations about the