University of Pittsburgh had begun immunization experiments in monkeys using dead polio virus. Soon, however, Salk began to test inoculations in paralyzed polio patients and by 1953 human trials among the general population were initiated. By the spring of the following year, the largest controlled field trials in medical history were underway, and by 1955 the vaccine developed by Salk and his researchers was declared effective. By 1962, Salk's vaccine had reduced the incidence of polio in the United States by 95 percent. The breakthroughs in immunology and vaccine development at Pitt by Salk and his team are considered one of the most
Salk Institute for Biological Studies becoming greener. The Salk Institute's open environment replete with empty space is symbolic of an open environment for creation, the symmetry stands for scientific precision, and submerging crevasses allow warm, natural light to enter the buildings like the intellectual light that leads to discovery. The contrast between balance and dynamic space manifests a pluralistic invitation for scientific study in structures developed to accommodate their respective functions as parts of a research facility. Although modern in appearance, it is essentially an isolated compound for individual and collaborative study, not unlike monasteries as sanctuaries for religious discovery, and they are thought to