Space Shuttle Columbia and ended in disaster 73 seconds after launch. In the aftermath NASA's shuttle timetable was disrupted, and "Columbia" was not flown again until 1989 (on STS-28), after which it resumed normal service as part of the shuttle fleet. STS-93, launched on July 23, 1999, was the first U.S. space mission with a female commander, Lt. Col. Eileen Collins. This mission deployed the Chandra X-ray Observatory. "Columbia"'s final successful mission was STS-109, the fourth servicing mission for the Hubble Space Telescope. Its next mission, STS-107, culminated in the orbiter's loss when it disintegrated during reentry, killing all seven of its crew.
Space Shuttle program and were formally initiated in 1983 by President Ronald Reagan, but the ISS suffered from long delays, design changes and cost over-runs and forced the service life of the Space Shuttle to be extended several times until 2011 when it was finally retired—serving twice as long than it was originally designed to do. In 2004, according to President George W. Bush's Vision for Space Exploration, use of the Space Shuttle was to be focused almost exclusively on completing assembly of the ISS, which was far behind schedule at that point. The first experimental orbiter "Enterprise" was a high-altitude glider, launched