The Nutty Professor (1996 film) research scientist, academic, and lecturer, Klump develops a miraculous, but experimental, weight-loss pharmaceutical, and hoping to win the affection of the girl of his dreams, tests it upon himself. Like the original film's Julius Kelp, Klump's vigorous, charismatic, but evil alter ego takes the name "Buddy Love". Murphy plays a total of seven characters in the film, including Sherman, most of Sherman's family (except for his nephew, Ernie Klump Jr. played by child actor Jamal Mixon), and an over-the-top parody of Richard Simmons. The film received positive reviews, with critics particularly praising the makeup and Murphy's performance. The film's success
Drug delivery to the brain is the presence of enzymes in the brain tissue that could render the drug inactive. The drug may be able to pass through the membrane fine, but will be deconstructed once it is inside the brain tissue rendering it useless. All of these are problems that must be addressed and accounted for in trying to deliver effective drug solutions to the brain tissue. A group from the University of Oxford led by Prof. Matthew Wood claims that exosomes can cross the blood–brain barrier and deliver siRNAs, antisense oligonucleotides, chemotherapeutic agents and proteins specifically to neurons after inject them systemically (in