Compulsory voting papers. Compulsory voting is increasingly resented by citizens in some countries such as Brazil, the largest country where compulsory voting is enforced: at the last presidential election in 2014, some 30 million voters, about 21% of registered voters, did not vote, despite the fact that Brazil has some of the most severe penalties enforced against non voters. A study of a Swiss canton where compulsory voting was enforced found that compulsory voting significantly increased electoral support for leftist policy positions in referenda by up to 20 percentage points. Another study found that the effects of universal turnout in the United
Catalytic triad Within protease superfamilies that contain a mixture of nucleophiles (e.g. the PA clan), families are designated by their catalytic nucleophile (C=cysteine proteases, S=serine proteases). A further subclass of catalytic triad variants are pseudoenzymes, which have triad mutations that make them catalytically inactive, but able to function as binding or structural proteins. For example, the heparin-binding protein Azurocidin is a homolog of PA clan, but with a glycine in place of the nucleophile and a serine in place of the histidine. Similarly, RHBDF1 is a homolog of the S54 family rhomboid proteases with an alanine in the place of the nucleophilic