Jim Fixx Jim Fixx James Fuller "Jim" Fixx (April 23, 1932 – July 20, 1984) was an American who wrote the 1977 best-selling book "The Complete Book of Running". He is credited with helping start America's fitness revolution, popularizing the sport of running and demonstrating the health benefits of regular jogging. He died of a heart attack while jogging at 52 years of age. His genetic predisposition for heart problems and other previous lifestyle factors may have caused his heart attack. Born in New York City, Fixx was a graduate of Trinity School in New York and Oberlin College in Ohio. His
Promoter bashing Promoter bashing Promoter bashing is a technique used in molecular biology to identify how certain regions of a DNA strand, commonly promoters, affect the transcription of downstream genes. Under normal circumstances, proteins bind to the promoter and activate or repress transcription. In a promoter bashing assay, specific point mutations or deletions are made in specific regions of the promoter and the transcription of the gene is then measured. The contribution of a region of the promoter can be observed by the level of transcription. If a mutation or deletion changes the level of transcription, then it is known that that