Charles Best House Charles H. Best was born. Best was educated at the University of Toronto, and in 1921 began a fruitful collaboration with Drs. Frederick Banting and J.J.R. Macleod. On January 11, 1922, Best administered the first dose of insulin to a human subject. Although he was did not formally share in the Nobel Prize in Medicine awarded in 1923 to Banting and Macleod, the latter shared his prize money with Best. Best continued his successful research career with the development of several enzyme-based therapies. He died in 1978. His birthplace was purchased in 1959 by the American Diabetes Association, and transferred
Highest and best use of the land as vacant exceeds the value of the property as improved less reversion/demolition costs, then redevelopment of the site becomes the maximally productive use of the property, and continued use of the existing improvements that do not represent the highest net value of the site is considered to be financially unfeasible. Finally, the use must generate the highest net return (profit) to the developer. A property that could hypothetically be developed with residential, commercial or industrial development might only have one of those uses as its highest and best use. These three hypothetical development scenarios follow to illustrate