November-class submarine Komsomol" was first underway under nuclear power on 4 July 1958 and became also the first Soviet submarine to reach the North Pole in July 1962, 4 years after the USS "Nautilus". Project 627 had much better performance specifications (for example, submerged speed and depth) than the world's first operational nuclear-powered submarine USS "Nautilus". The first commander of "K-3" was Captain 1st Rank L.G. Osipenko (future admiral and Hero of the Soviet Union). All other Novembers except "K-3" belonged to modified project – project 627A. The main visual differences of project 627A were a bow sonar dome in the keel
Nuclear cap-binding protein complex Nuclear cap-binding protein complex Nuclear cap-binding protein complex is a RNA-binding protein which binds to the 5' cap of pre-mRNA. The cap and nuclear cap-binding protein have many functions in mRNA biogenesis including splicing, 3'-end formation by stabilizing the interaction of the 3'-end processing machinery, nuclear export and protection of the transcripts from nuclease degradation. When RNA is exported to the cytoplasm the nuclear cap-binding protein complex is replaced by cytoplasmic cap binding complex. The nuclear cap-binding complex is a functional heterodimer and composed of Cbc1/Cbc2 in yeast and CBC20/CBC80 in multicellular eukaryotes. Human nuclear cap-binding protein complex shows the