Charles Best (medical scientist) and Noble flipped a coin to see which would assist Banting first. Best won and took the first shift. Loss of the coin toss proved unfortunate for Noble, given that Banting decided to keep Best for the entire summer and eventually shared half of his Nobel Prize money and a part of the credit for the discovery of insulin. Had Noble won the toss, his career might have taken a different path. MacLeod was overseeing the work of Banting, who had no experience of physiology, and his assistant Best. In December, when Banting and Best were having difficulties in refining
Highest and best use the highest and best use is the commercial lot use. The market value of the property is driven by this hypothetical conversion, even if it never takes place, due to the utility that this potential conversion would bring to a purchaser. The economic concepts of utility and substitution drive the highest and best use analysis. The highest and best use of a property determines its utility to a potential purchaser. A purchaser will pay no more for a property than a competing property with the same utility would command, while a seller would accept no less than another seller of