Frederick Banting in the blood which was then excreted in urine. Attempts to extract insulin from ground-up pancreas cells were unsuccessful, likely because of the destruction of the insulin by the proteolysis enzyme of the pancreas. The challenge was to find a way to extract insulin from the pancreas prior to its being destroyed. Moses Barron published an article in 1920 which described experimental closure of the pancreatic duct by ligature; this further influenced Banting's thinking. The procedure caused deterioration of the cells of the pancreas that secrete trypsin which breaks down insulin, but it left the islets of Langerhans intact. Banting
William Banting James’s Street, London, was among the most eminent companies of funeral directors in Britain. As funeral directors to the Royal Household itself, the Banting family conducted the funerals of King George III in 1820, King George IV in 1830, the Duke of Gloucester in 1834, the Duke of Wellington in 1852, Prince Albert in 1861, Prince Leopold in 1884, Queen Victoria in 1901, and King Edward VII in 1910. The royal undertaking warrant for the Banting family eventually ended in 1928 with the retirement of William Westport Banting. In 1863, Banting wrote a booklet called "Letter on Corpulence, Addressed to