Naval Submarine Base New London by the Submarine Escape Immersion Equipment in the 2000s. On January 21, 1954 the first nuclear-powered submarine, , was launched from Groton. "Nautilus" became the first vessel to transit the North Pole during a historic trip across the Arctic in 1958. "Nautilus" spent most of her career assigned to Submarine Squadron 10 located at State Pier in New London. It was retired from service in 1980. In 1982 "Nautilus" was designated a National Historic Landmark in Groton. It is permanently moored south of the main gate, attached to the U.S. Submarine Force Museum. Self-guided tours are available to the public
Nuclear cap-binding protein complex Nuclear cap-binding protein complex Nuclear cap-binding protein complex is a RNA-binding protein which binds to the 5' cap of pre-mRNA. The cap and nuclear cap-binding protein have many functions in mRNA biogenesis including splicing, 3'-end formation by stabilizing the interaction of the 3'-end processing machinery, nuclear export and protection of the transcripts from nuclease degradation. When RNA is exported to the cytoplasm the nuclear cap-binding protein complex is replaced by cytoplasmic cap binding complex. The nuclear cap-binding complex is a functional heterodimer and composed of Cbc1/Cbc2 in yeast and CBC20/CBC80 in multicellular eukaryotes. Human nuclear cap-binding protein complex shows the