Charles Best House Charles H. Best was born. Best was educated at the University of Toronto, and in 1921 began a fruitful collaboration with Drs. Frederick Banting and J.J.R. Macleod. On January 11, 1922, Best administered the first dose of insulin to a human subject. Although he was did not formally share in the Nobel Prize in Medicine awarded in 1923 to Banting and Macleod, the latter shared his prize money with Best. Best continued his successful research career with the development of several enzyme-based therapies. He died in 1978. His birthplace was purchased in 1959 by the American Diabetes Association, and transferred
Highest and best use higher values for their non-timber amenities such as for recreation and conservation.” Organizations such as the American Society of Farm Managers and Rural Appraisers (ASFMRA), the American Society of Appraisers (ASA) and the Appraisal Institute have issued guidance to their members stating that the use of non-economic valuation concepts such as the above must not be used in connection with concepts such as Market Value and Highest and Best Use when engaging in typical appraisal assignments. However, proponents of alternate valuation metrics point out that valuing land through a purely economic perspective often fails to capture important benefits to the