Charles Kirkconnell International Airport round trip service flown with a Beech Model 18 twin prop aircraft on a routing of Grand Cayman - Little Cayman (flag stop only) - Cayman Brac - Montego Bay. According to the airline's May 1, 1965 timetable, connecting service to Miami via Grand Cayman was offered by LACSA, an airline based in Costa Rica, while additional CBA connecting service to Miami as well as to New York City was offered by Pan Am via Montego Bay. In 1968, the government of the Cayman Islands purchased a controlling interest in Cayman Brac Airways from LACSA and then formed Cayman Airways
Darwin Airline company. In early 2014, Etihad Regional leased four ATR 72-500s from Nordic Aviation Capital to expand routes from Geneva. From the end of March 2014, the airline withdrew its Ancona-Roma Fiumicino and Trapani-Roma Fiumicino routes, as a result of cabotage restrictions, which prevent Swiss aviation companies from operating domestic flights in the European Union. It was previously possible for Darwin Airline to fly these routes thanks to a derogation from the Italian Civil Aviation Authority, however, this was not renewed. In January 2014, Darwin Airline cancelled its Aosta-Roma Fiumicino route before it had commenced; a result of the same cabotage