North Pole Since 2002, the Russians have also annually established a base, Barneo, close to the Pole. This operates for a few weeks during early spring. Studies in the 2000s predicted that the North Pole may become seasonally ice-free because of Arctic ice shrinkage, with timescales varying from 2016 to the late 21st century or later. The sea depth at the North Pole has been measured at by the Russian Mir submersible in 2007 and at 4,087 m (13,410 ft) by USS "Nautilus" in 1958. The nearest land is usually said to be Kaffeklubben Island, off the northern coast of Greenland about
Nuclear cap-binding protein complex Nuclear cap-binding protein complex Nuclear cap-binding protein complex is a RNA-binding protein which binds to the 5' cap of pre-mRNA. The cap and nuclear cap-binding protein have many functions in mRNA biogenesis including splicing, 3'-end formation by stabilizing the interaction of the 3'-end processing machinery, nuclear export and protection of the transcripts from nuclease degradation. When RNA is exported to the cytoplasm the nuclear cap-binding protein complex is replaced by cytoplasmic cap binding complex. The nuclear cap-binding complex is a functional heterodimer and composed of Cbc1/Cbc2 in yeast and CBC20/CBC80 in multicellular eukaryotes. Human nuclear cap-binding protein complex shows the