Polonium initiator was classified until the 1960s. The Atomic Energy Commission and the Manhattan Project funded human experiments using polonium on five people at the University of Rochester between 1943 and 1947. The people were administered between of polonium to study its excretion. Polonium is a very rare element in nature because of the short half-life of all its isotopes. Po, Po, and Po appear in the decay chain of U; thus polonium can be found in uranium ores at about 0.1 mg per metric ton (1 part in 10), which is approximately 0.2% of the abundance of radium. The amounts
Operation Sandstone month. A "Fat Man" core required about of plutonium, of which 21% fissioned. Plutonium production fell off during 1946 due to swelling of the reactors' graphite neutron moderators. This is known as the Wigner effect, after its discoverer, the Manhattan Project scientist Eugene Wigner. These reactors were also required for the production (by irradiation of bismuth-209) of polonium-210, which was used in the initiators, a critical component of the nuclear weapons. Some of bismuth-209 had to be irradiated for 100 days to produce 600 curies of polonium-210, a little over . Because polonium-210 has a half-life of only 138 days,