Polonium in the Earth's crust are not harmful. Polonium has been found in tobacco smoke from tobacco leaves grown with phosphate fertilizers. Because it is present in small concentrations, isolation of polonium from natural sources is a tedious process. The largest batch of the element ever extracted, performed in the first half of the 20th century, contained only (9 mg) of polonium-210 and was obtained by processing 37 tonnes of residues from radium production. Polonium is now usually obtained by irradiating bismuth with high-energy neutrons or protons. In 1934, an experiment showed that when natural Bi is bombarded with neutrons, Bi
Operation Sandstone month. A "Fat Man" core required about of plutonium, of which 21% fissioned. Plutonium production fell off during 1946 due to swelling of the reactors' graphite neutron moderators. This is known as the Wigner effect, after its discoverer, the Manhattan Project scientist Eugene Wigner. These reactors were also required for the production (by irradiation of bismuth-209) of polonium-210, which was used in the initiators, a critical component of the nuclear weapons. Some of bismuth-209 had to be irradiated for 100 days to produce 600 curies of polonium-210, a little over . Because polonium-210 has a half-life of only 138 days,