Radium seventh of a gram of radium. One kilogram of the Earth's crust contains about 900 picograms of radium, and one liter of sea water contains about 89 femtograms of radium. Radium was discovered by Marie Sklodowska-Curie and her husband Pierre Curie on 21 December 1898, in a uraninite (pitchblende) sample. While studying the mineral earlier, the Curies removed uranium from it and found that the remaining material was still radioactive. They separated out an element similar to bismuth from pitchblende in July 1898, that turned out to be polonium. They then separated out a radioactive mixture consisting mostly of two
Polonium methylated in living things to create organometallic compounds. Studies investigating the metabolism of polonium-210 in rats have shown that only 0.002 to 0.009% of polonium-210 ingested is excreted as volatile polonium-210. The median lethal dose (LD) for acute radiation exposure is about 4.5 Sv. The committed effective dose equivalent Po is 0.51 µSv/Bq if ingested, and 2.5 µSv/Bq if inhaled. So a fatal 4.5 Sv dose can be caused by ingesting , about 50 nanograms (ng), or inhaling , about 10 ng. One gram of Po could thus in theory poison 20 million people of whom 10 million would die.