Charles Best (medical scientist) and Noble flipped a coin to see which would assist Banting first. Best won and took the first shift. Loss of the coin toss proved unfortunate for Noble, given that Banting decided to keep Best for the entire summer and eventually shared half of his Nobel Prize money and a part of the credit for the discovery of insulin. Had Noble won the toss, his career might have taken a different path. MacLeod was overseeing the work of Banting, who had no experience of physiology, and his assistant Best. In December, when Banting and Best were having difficulties in refining
Highest and best use Since their use predates these regulations, they are "grandfathered in". However, some such uses may not be reproduced if the legally nonconforming improvement is destroyed or damaged beyond a certain point. "Legally permissible" can be a tricky conceptual test, because even uses that are currently not permitted may be considered. This happens when there is a reasonable prospect (at least 50%) that the regulation, zoning, deed restriction, etc. can be changed to permit the proposed use. Any potential use must be physically possible given the size, shape, topography, and other characteristics of the site. For example, a single story warehouse