Polonium the Curies while they were investigating the cause of pitchblende radioactivity. Pitchblende, after removal of the radioactive elements uranium and thorium, was more radioactive than the uranium and thorium combined. This spurred the Curies to search for additional radioactive elements. They first separated out polonium from pitchblende in July 1898, and five months later, also isolated radium. German scientist Willy Marckwald successfully isolated 3 milligrams of polonium in 1902, though at the time he believed it was a new element, which he dubbed "radio-tellurium", and it was not until 1905 that it was demonstrated to be the same as polonium.
Polonium methylated in living things to create organometallic compounds. Studies investigating the metabolism of polonium-210 in rats have shown that only 0.002 to 0.009% of polonium-210 ingested is excreted as volatile polonium-210. The median lethal dose (LD) for acute radiation exposure is about 4.5 Sv. The committed effective dose equivalent Po is 0.51 µSv/Bq if ingested, and 2.5 µSv/Bq if inhaled. So a fatal 4.5 Sv dose can be caused by ingesting , about 50 nanograms (ng), or inhaling , about 10 ng. One gram of Po could thus in theory poison 20 million people of whom 10 million would die.