Polonium subjects were chosen because experimenters wanted persons who had not been exposed to polonium either through work or accident. All subjects had incurable diseases. Excretion of polonium was followed, and an autopsy was conducted at that time on the deceased patient to determine which organs absorbed the polonium. Patients' ages ranged from 'early thirties' to 'early forties'. The experiments were described in Chapter 3 of Biological Studies with Polonium, Radium, and Plutonium, National Nuclear Energy Series, Volume VI-3, McGraw-Hill, New York, 1950. Not specified is the isotope under study, but at the time polonium-210 was the most readily available polonium
Modulated neutron initiator particle bombardment, the beryllium atoms emit neutrons at a rate of about 1 neutron each 5–10 nanoseconds (See Beryllium#Nuclear properties). These neutrons trigger the chain reaction in the compressed supercritical plutonium. Placing the polonium layer between two large masses of beryllium ensures contact of the metals even if the shock wave turbulence performs poorly. The 50 curies of polonium generated about 0.1 watts of decay heat, noticeably warming the small sphere. The grooves in the inner surface of the shell shaped the shock wave into jets by the Munroe effect, similar to a shaped charge, for fast and thorough mixing