Frederick Banting realized that this procedure would destroy the trypsin-secreting cells but not the insulin. Once the trypsin-secreting cells had died, insulin could be extracted from the islets of Langerhans. Banting discussed this approach with J. J. R. Macleod, Professor of Physiology at the University of Toronto. Macleod provided experimental facilities and the assistance of one of his students, Charles Best. Banting and Best, with the assistance of biochemist James Collip, began the production of insulin by this means. As the experiments proceeded, the required quantities could no longer be obtained by performing surgery on living dogs. In November 1921, Banting hit
William Banting William Banting William Banting ("c." December 1796 – 16 March 1878) was a notable English undertaker. Formerly obese, he is also known for being the first to popularise a weight loss diet based on limiting the intake of carbohydrates, especially those of a starchy or sugary nature. He undertook his dietary changes at the suggestion of Soho Square physician Dr. William Harvey, who in turn had learned of this type of diet, but in the context of diabetes management, from attending lectures in Paris by Claude Bernard. In the early 19th century, the family business of William Banting of St.