Can't Fight This Feeling Can't Fight This Feeling "Can't Fight This Feeling" is a power ballad performed by the American rock band REO Speedwagon. The single remained at the top of the Billboard Hot 100 chart for three consecutive weeks from March 9 to March 23, 1985. The song first appeared on REO Speedwagon's 1984 album "Wheels Are Turnin'". It was the group's second number-one hit on the U.S. charts (the first being 1981's "Keep on Loving You", also written by Kevin Cronin) and reached number sixteen in the UK. "Can't Fight This Feeling" has appeared on dozens of 'various artists' compilation albums, as
Hit selection and SSMD* for cases without replicates. In a screen with replicates, we can directly estimate data variability for each compound, and thus we can use more powerful methods, such as SSMD for cases with replicates and t-statistic that does not rely on the strong assumption that the z-score and z*-score rely on. One issue with the use of t-statistic and associated p-values is that they are affected by both sample size and effect size . They come from testing for no mean difference, thus are not designed to measure the size of small molecule or siRNA effects. For hit selection,