Charles Best House Charles H. Best was born. Best was educated at the University of Toronto, and in 1921 began a fruitful collaboration with Drs. Frederick Banting and J.J.R. Macleod. On January 11, 1922, Best administered the first dose of insulin to a human subject. Although he was did not formally share in the Nobel Prize in Medicine awarded in 1923 to Banting and Macleod, the latter shared his prize money with Best. Best continued his successful research career with the development of several enzyme-based therapies. He died in 1978. His birthplace was purchased in 1959 by the American Diabetes Association, and transferred
Highest and best use both "as improved" and "as if vacant". Vacant properties are generally only given the "as vacant" test. The Highest and Best Use as vacant may be the same or different as the Highest and Best use as improved. For improved properties, the first analysis applied is the use of the property based on the assumption that the parcel is vacant. Then, the analysis focuses on the use that should be made of the property as it is currently improved. The extent to which the existing improvements differ from the highest and best use as-if vacant, reveals the extent of any