Charles Best (medical scientist) and Noble flipped a coin to see which would assist Banting first. Best won and took the first shift. Loss of the coin toss proved unfortunate for Noble, given that Banting decided to keep Best for the entire summer and eventually shared half of his Nobel Prize money and a part of the credit for the discovery of insulin. Had Noble won the toss, his career might have taken a different path. MacLeod was overseeing the work of Banting, who had no experience of physiology, and his assistant Best. In December, when Banting and Best were having difficulties in refining
Highest and best use for a property is arrived at. In any case where the market value of real property is sought, that value must be based on its highest and best use. Highest and best use is always that use that would produce the highest value for a property, regardless of its actual current use. The Appraisal Institute of Canada defines the term highest and best use as: The reasonably probable and legal use of property, that is physically possible, appropriately supported, and financially feasible, and that results in the highest value. The Appraisal Institute defines highest and best use as follows: The