Frederick Banting in the blood which was then excreted in urine. Attempts to extract insulin from ground-up pancreas cells were unsuccessful, likely because of the destruction of the insulin by the proteolysis enzyme of the pancreas. The challenge was to find a way to extract insulin from the pancreas prior to its being destroyed. Moses Barron published an article in 1920 which described experimental closure of the pancreatic duct by ligature; this further influenced Banting's thinking. The procedure caused deterioration of the cells of the pancreas that secrete trypsin which breaks down insulin, but it left the islets of Langerhans intact. Banting
Banting and Best Centre for Innovation and Entrepreneurship developed in 1921. The Centre, managed by the University of Toronto, set up facilities to foster collaborative work between students, faculty and private enterprise by providing office space, courses and equipment. The centre has also provided jobs for students and recent graduates of the university. Soon after its establishment, the centre began raising money from private investors to fund startup companies. During the first year about $23 million was raised. As of 2016, the centre operates nine business accelerators. Banting and Best Centre for Innovation and Entrepreneurship The Banting and Best Centre for Innovation and Entrepreneurship is an initiative of