Polonium initiator was classified until the 1960s. The Atomic Energy Commission and the Manhattan Project funded human experiments using polonium on five people at the University of Rochester between 1943 and 1947. The people were administered between of polonium to study its excretion. Polonium is a very rare element in nature because of the short half-life of all its isotopes. Po, Po, and Po appear in the decay chain of U; thus polonium can be found in uranium ores at about 0.1 mg per metric ton (1 part in 10), which is approximately 0.2% of the abundance of radium. The amounts
Polonium radioactive noble gas radon-222, some of which, during its 3.8-day half-life, diffuses into the atmosphere. There it decays through several more steps to polonium-210, much of which, during its 138-day half-life, is washed back down to the Earth's surface, thus entering the biosphere, before finally decaying to stable lead-206. As early as the 1920s Antoine Lacassagne, using polonium provided by his colleague Marie Curie, showed that the element has a specific pattern of uptake in rabbit tissues, with high concentrations, particularly in liver, kidney, and testes. More recent evidence suggests that this behavior results from polonium substituting for its congener