These pharmacologically- mediated undesirable effects, known from preclinical studies with both angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists, were prevented by oral saline supplementation.
Disse farmakologisk betingede bivirkninger, som er kendt fra prækliniske forsøg med både ACE- hæmmere og angiotensin II- receptorantagonister, kunne forhindres/ afhjælpes ved peroral salttilførsel.