Pharmacodynamic properties Spironolactone and its active metabolites (including 7α -thiomethyl-spironolactone and canrenone) act as specific antagonists of aldosterone, and exert their effects by binding competitively to the mineralocorticoid receptor located in the kidneys, heart and blood vessels.
Farmakodynamiske egenskaber Spironolacton og dets aktive metabolitter (inklusiv 7α- thiomethyl- spironolactone og canrenon) fungerer som en specifik antagonist i forhold til aldosteron, og udøver deres effekt ved kompetitiv binding til mineralokortikoid - receptor, lokaliseret i nyrer, hjerte og blodkar.