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Physiological and pathological changes are main inducing factors of diminished kidney function, which includes trauma, infection, inflammation, immune response, blood circulatory disorder, etc.
In many cases, kidney shrinkage occurs as a result of kidney failure which is the worst kidney condition and also the final consequence of both chronic and acute kidney problem. For people with kidney shrinkage caused by kidney failure, their residual kidney function is proportional to the size of their kidney.