Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
Weighted average grade: The weighted grade is equal to the sum of the product of the weights (w) in percent (%) times the grade (g): Weighted grade = w 1 Ã g 1 + w 2 Ã g 2 + w 3 Ã g 3 +...When the weights are not in percent (hours or points...), you should also divided by the sum of the weights:Weighted grade = (w 1 Ã g 1 + w 2 Ã g 2 + w 3 Ã g 3 +...) / (w 1 + w 2 + w 3 +...).hen the weights are not in percent (hours or points...), you should also divided by the sum of the weights: Weighted grade = (w 1 Ã g 1 + w 2 Ã g 2 + w 3 Ã g 3 +...) / (w 1 + w 2 + w 3 +...).