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Physiological and pathological changes are main inducing factors of diminished kidney function, which includes trauma, infection, inflammation, immune response, blood circulatory disorder, etc.
As a person's kidney function declines due to damage or disease, the filtration rate decreases and waste products begin to accumulate in the blood. Chronic kidney disease (CKD) is associated with a decrease in kidney function that is often progressive.s a person's kidney function declines due to damage or disease, the filtration rate decreases and waste products begin to accumulate in the blood. Chronic kidney disease (CKD) is associated with a decrease in kidney function that is often progressive.