While orange or brownish urine can have a multitude of causes, liver disease must be ruled out. Cirrhosis, hepatitis, pancreatic cancer, pancreatitis, bile duct cancer or blockage and alcoholic liver disease all are known to cause dark urine.
effectuating. 1  A failed attempt at trying to sound smart using a word that sounds like it might mean something but, in reality, means nothing at all. 2  A failed attempt at trying to sound smart using a word that sounds like it might mean something but, in reality, means nothing at all.
If something neutralizes the effect of something else, then you can say the effect is negated. Hanging a disco ball from your living room ceiling negates the sleek modern effect created by the contemporary furniture. If something is proved false or untrue, it has been negated.