Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
1 To figure out an Unweighted GPA, skip Step #3 and #4 and divide Total Grade Points (Step #2) by Total # of Semesters (Step #1).  A Fully Weighted GPA is one in which all extra points are added to the GPA. To compute a Fully Weighted GPA, divide the Grand Point Total (Step #4) by the Total # of Semesters (Step #1).