Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
If your school uses weighted GPA and youâre in some AP or Honors classes where less than perfect grades will translate into impressive GPAs, you should focus your efforts on raising your grades in those classes. On weighted GPA scales, GPAs often go up to a 5.0 rather than a 4.0 to account for more difficult classes.