Forces That Drive Tertiary Structure. Most proteins fold into their tertiary structure in an aqueous environment-a cell is, after all, 60% water. The chemical properties of the various R-groups (sidechains) of the amino acids within the protein chain will influence the way that the protein folds in its environment.
This cold sensation will last approximately three to five minutes until a burning sensation appears. The burning sensation will fade into an ache, followed by numbness. Beware that once numbing occurs, remove and discontinue the ice. Continued application following numbing may result in tissue damage.
Ice is useful for reducing pain and inflammation associated with an acute injury. Icing is most effective if done the first couple of days after the injury has occurred. You can apply ice for 20 minutes at a time and as frequently as every hour. If you prefer, apply it four to eight times a day.