Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
You can add both weighted and unweighted high school classes. Your weighted classes receive extra points on the GPA scale, such as, Honors and AP classes. Unweighted classes are regular and do not carry any extra points. If you have taken a weighted class, select Honors, AP, or IB.