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What causes a fistula? After an abscess has been drained, a passage may remain between the anal gland and the skin, resulting in a fistula. If the gland does not heal, there will be persistent drainage through this passage. If the outside opening of the fistula heals first, a recurrent abscess may develop.
Depending on where the leak is, gastrointestinal fistulas may cause diarrhea, malabsorption of nutrients, and dehydration. 1  Entero-enteral fistulas may have no symptoms.  Enterocutaneous fistulas cause intestinal contents to leak through an opening in the skin.