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Glycolysis is the first stage of aerobic (and anaerobic) respiration. It takes place in the cytoplasm of the cell. In glycolysis (âglucose breakingâ), ATP is used to split glucose molecules into a three-carbon compound called pyruvate. This splitting produces energy that is stored in ATP and a molecule called NADH.
View Full Document. Anaerobic respiration (both glycolysis and fermentation) takes place in the fluid portion of the cytoplasm whereas the bulk of the energy yield of aerobic respiration takes place in the mitochondria. Anaerobic respiration leaves a lot of energy in the ethanol or lactate molecules that the cell cannot use and must excrete.