Pre-symptomatic late infantile MLD patients, as well as those with juvenile or adult MLD that are either presymptomatic or displaying mild symptoms, can consider bone marrow transplantation (including stem cell transplantation), which may slow down progression of the disease in the central nervous system.
Dose-dependent effects of the indicated TBEV inhibitors on virus titres. PS cells were infected with TBEV at a multiplicity of infection (MOI) of 0.1 and treated with 2â²-C-methylguanosine (A), 2â²-C-methyluridine (B), RO-9187 (C) and (D) 4â²-azidocytidine at the indicated concentrations.
Effect of GFX and PMA on colony morphology of the cells. To confirm the speculation that PKCs play roles in regulating self-renewal in hPS cells, the effect of the PKC activator PMA with several kinase inhibitors on the culture of 201B7 hiPS cells was determined (Fig. 3A). Treatment with PMA scattered the iPS cell colony dramatically.