Pre-symptomatic late infantile MLD patients, as well as those with juvenile or adult MLD that are either presymptomatic or displaying mild symptoms, can consider bone marrow transplantation (including stem cell transplantation), which may slow down progression of the disease in the central nervous system.
Dose-dependent effects of the indicated TBEV inhibitors on virus titres. PS cells were infected with TBEV at a multiplicity of infection (MOI) of 0.1 and treated with 2â²-C-methylguanosine (A), 2â²-C-methyluridine (B), RO-9187 (C) and (D) 4â²-azidocytidine at the indicated concentrations.
View all figures. 1  Figure 1: TBEV can infect human neurons. (A) TBEV titers in culture supernatants from HNs collected at 0, 3, 5, 7, and 12 days post-infection (p.i.) were determined in plaque assays with porcine kidney stable cells. 2  Figure 2: Confocal images of human neurons infected with TBEV.