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Physiological and pathological changes are main inducing factors of diminished kidney function, which includes trauma, infection, inflammation, immune response, blood circulatory disorder, etc.
The progression of kidney disease can be slowed, but it cannot always be reversed. End-stage renal disease (ESRD) is the total loss of kidney function. Dialysis and transplantation can extend the lives of people with ESRD. Diabetes and high blood pressure are the two leading causes of kidney failure. You should see a nephrologist regularly if you have renal disease.