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Donât ignore possible physical symptoms of depression: Pain and other changes in your health can actually be the first signs of depression, and knowing about possible physical effects of depression may help you get diagnosed and treated earlier.
Depression affects different people in different ways, but most of them experience some combination of the following symptoms: 1  Prolonged sadness or feelings of emptiness. 2  Feelings of helplessness or hopelessness. 3  Feelings of guilt or worthlessness.  Anger and 1  irritability. Restlessness.  Difficulty 1  concentrating. Fatigue.  Changes in sleep patterns.