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Physiological and pathological changes are main inducing factors of diminished kidney function, which includes trauma, infection, inflammation, immune response, blood circulatory disorder, etc.
Topic Overview. Kidney failure occurs when the kidneys lose their ability to function. To treat kidney failure effectively, it is important to know whether kidney disease has developed suddenly (acute) or over the long term (chronic). Symptoms may reflect the actual cause of the kidney problem. 2  An obstruction in the urinary tract may cause pain in the side or lower back (flank pain), blood in the urine, or reduced urine output. 3  Dehydration may cause extreme thirst; lightheadedness or faintness; a weak, rapid pulse; and other symptoms.