Forces That Drive Tertiary Structure. Most proteins fold into their tertiary structure in an aqueous environment-a cell is, after all, 60% water. The chemical properties of the various R-groups (sidechains) of the amino acids within the protein chain will influence the way that the protein folds in its environment.
This cold sensation will last approximately three to five minutes until a burning sensation appears. The burning sensation will fade into an ache, followed by numbness. Beware that once numbing occurs, remove and discontinue the ice. Continued application following numbing may result in tissue damage.
Treatment of ice pack burn: You may notice having an ice pack burn if you start developing the signs and symptoms of cold induced injury such as developing blisters, feel burning, numb, itchiness and/or pain sensation in the affected area. The color of the affected skin may turn yellowish-gray.