The Shinnston News & Harrison County Journal. WV DOH News-Road Closure: The WV DOH advises motorists that Wednesday, September 5th, Harrison County Route 14-Little Rock Camp Road will be closed due to a culvert replacement. The hours for this closure are from 8:00am to 5:00pm.
Cysteine residues in homologous proteins (those of common ancestry) are very conservative according to PAM 250 scoring matrix . Only Trp is statistically more conservative than Cys. Fig 4. PAM 250 scoring matrix of Dayhoff mutation data matrix. Note that the highest values indicating replacement of a residue into itself is for Trp and Cys. That means the two residues are the most conservative in homologous sequences. The reason is that cysteine - because of disulfide bridges - plays very important role in stabilization of protein structure at higher level.
Cytochrome c is a highly conserved ~12 kDa protein consisting of a single 104 amino acid peptide with a single heme group, which is covalently attached to Cys 14 and Cys 17.Because of its ubiquitous nature and sequence homology, cytochrome c has been used as a model protein for molecular evolution. 1.ytochrome c also participates in the cytosolic caspase proteolytic cascade of apoptosis as a component of the apoptotic protease activating factor (Apaf). The association of cytochrome c with Apaf-1 results in the formation of the apoptosome protein complex which can recruit and activate pro-caspase 9 (Apaf-3).