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Physiological and pathological changes are main inducing factors of diminished kidney function, which includes trauma, infection, inflammation, immune response, blood circulatory disorder, etc.
1 Stage 2 â Signs of mild kidney disease with reduced GFR (indicating 60% to 89% kidney function). 2  Stage 4 â Signs of severe chronic renal insufficiency (where the GFR indicates 15% to 29% kidney function).  Stage 5 â Signs of end stage renal failure (where the GFR indicates less than 15% kidney function).