Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
Though you may be a bit nervous about taking a weighted class, many of the course offerings are extraordinarily empowering. Honors classes offered by high schools typically carry a 0.5 point weight increase and are designed to be a more in-depth variation of your core classes, such as, Honors English.hen the total number of points earned is divided by the number of credits taken, you will be left with your GPA. Such a number can be used by administrators to rank students within their graduating class. An A in an AP calculus class, however, will be worth 5 points instead of 4 points and is considered weighted.