When people say that something really gets my goat,â they mean that they are extremely irritated. A wide variety of things could contribute to irritation, ranging from someone else's actions to a series of events, but, despite the turn of phrase, goats are not usually involved.
The major activator of Rho family GTPase is GPCR (G-Protein coupled Receptor). GPCRs that activate Rho and use G-Alpha12 or G-Alpha13 for signal transduction include receptors for LPA (Lysophosphatidic Acid) and S-1P (Sphingosine 1-Phosphate) and certain Hormones. Besides GPCR, Itgs (Integrins) also activate Rho GTPase.
That's the same with the 599 GTB and GTO. The GTB is the Grand Tourer, the standard road version, while the GTO is the version qualified to race in the Grand Touring class. In simpler terms, the GTB is the cheaper, more avaliable (more units made) road version of the 599, while the GTO is the more expensive, more hardcore, track-orientated version.