Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
answered Oct 13, 2012 by Hailee_661 (Student) (730 points). A usually GPA scale is based on a 4.0. Unweighted: The unweighted GPA is the average of all class grades based on a 4.0 scale. Weighted: A weighted GPA gives different point values based on a 4.0 scale to AP and regular classes, AP usually weighing more.