Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
This is what is they mean when they ask for your weighted or unweighted GPA. Weighted GPA Many schools offer accelerated and Advanced Placement (AP) classes to students who show academic merit. To distinguish an âAâ in the advanced geometry class from that in the regular one, schools often assign a different point system to harder classes.