Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
In addition, some colleges and universities may ask high schools to provide both weighted and unweighted GPAs on student transcripts so that admissions offices can evaluate the differential effect of weighted gradesâi.e., how certain course selections and weighted grades affected the GPA calculation.