Pre-symptomatic late infantile MLD patients, as well as those with juvenile or adult MLD that are either presymptomatic or displaying mild symptoms, can consider bone marrow transplantation (including stem cell transplantation), which may slow down progression of the disease in the central nervous system.
Dose-dependent effects of the indicated TBEV inhibitors on virus titres. PS cells were infected with TBEV at a multiplicity of infection (MOI) of 0.1 and treated with 2â²-C-methylguanosine (A), 2â²-C-methyluridine (B), RO-9187 (C) and (D) 4â²-azidocytidine at the indicated concentrations.
The CD4 cells called helper T cells help B lymphocytes recognize certain antigens. Amplifier T lymphocytes are CD8 cells that enhance the activity of cytotoxic T cells. Suppressor T cells are CD8 cells that suppress antibody synthesis by their action on helper cells and B lymphocytes.