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Ganglion cysts are the most common mass or lump in the hand. They are not cancerous and, in most cases, are harmless. They occur in various locations, but most frequently develop on the back of the wrist. These fluid-filled cysts can quickly appear, disappear, and change size.
1 Rarely, ganglion cysts can occur in children younger than 10 years of age.  Ganglion cysts most commonly occur on the back of the hand, at the wrist joint, and can also develop on the palm side of the wrist. When found on the back of the wrist, they become more prominent when the wrist is flexed forward.