Pre-symptomatic late infantile MLD patients, as well as those with juvenile or adult MLD that are either presymptomatic or displaying mild symptoms, can consider bone marrow transplantation (including stem cell transplantation), which may slow down progression of the disease in the central nervous system.
Dose-dependent effects of the indicated TBEV inhibitors on virus titres. PS cells were infected with TBEV at a multiplicity of infection (MOI) of 0.1 and treated with 2â²-C-methylguanosine (A), 2â²-C-methyluridine (B), RO-9187 (C) and (D) 4â²-azidocytidine at the indicated concentrations.
The central role of CD4 + T cells in delayed hypersensitivity is illustrated in patients with AIDS. Because of the loss of CD4 + cells, the host response against intracellular pathogens such as Mycobacterium tuberculosis is markedly impaired. The bacteria are engulfed by macrophages but are not killed.