Forces That Drive Tertiary Structure. Most proteins fold into their tertiary structure in an aqueous environment-a cell is, after all, 60% water. The chemical properties of the various R-groups (sidechains) of the amino acids within the protein chain will influence the way that the protein folds in its environment.
This cold sensation will last approximately three to five minutes until a burning sensation appears. The burning sensation will fade into an ache, followed by numbness. Beware that once numbing occurs, remove and discontinue the ice. Continued application following numbing may result in tissue damage.
Immediately following injury the principles of PRICE or rest, ice, compression and elevation should be applied. Ice or cold therapy should be applied as soon as physically possible and for 10 to 15 minutes every hour during the acute stage. This is usually the first 24 to 48 hours depending on how bad the injury is. Ice should not be applied directly to the skin as ice burns can occur but use a wet tea towel. Commercially available hot and cold packs are often more convenient to use in the long run.