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As with other thyroid-related problems, nodules are more common in women than men and the risk in both sexes increases with age. Most thyroid nodules do not cause any symptoms. However, if they grow large enough, they can cause swelling in the neck and lead to breathing and swallowing difficulties, pain, and goiter.
In such cases, the disorder is called primary hypothyroidism. (Secondary hypothyroidism is caused by disorders of the pituitary gland. Tertiary hypothyroidism is caused by disorders of the hypothalamus.). The two most common causes of primary hypothyroidism are: 1  Hashimoto's thyroiditis.2  This is an autoimmune condition in which the body's immune system attacks its own cells. 3  Overtreatment of hyper thyroidism (an overactive thyroid).ertiary hypothyroidism is caused by disorders of the hypothalamus.). The two most common causes of primary hypothyroidism are: 1  Hashimoto's thyroiditis. 2  This is an autoimmune condition in which the body's immune system attacks its own cells. 3  Overtreatment of hyper thyroidism (an overactive thyroid).