Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
Calculating a GPA with Weighted Credit Hours. 1  1. Determine the number of credits. 2  2. Assign the appropriate scale value for each letter grade. 3  3. Calculate the weighted scores.  4. Find your total weighted 1  credits. 5. Divide the grade points total by the credit hours total.