Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
However, in honors or AP classes, an A will translate into a 5.0 weighted GPA, a B will be a 4.0, and so on. If your school has mid-level classes, an A might translate into a 4.5 GPA. Keep in mind that these are general estimates; if your school records weighted GPAs, you should check the specific policies.