When people say that something really gets my goat,â they mean that they are extremely irritated. A wide variety of things could contribute to irritation, ranging from someone else's actions to a series of events, but, despite the turn of phrase, goats are not usually involved.
The major activator of Rho family GTPase is GPCR (G-Protein coupled Receptor). GPCRs that activate Rho and use G-Alpha12 or G-Alpha13 for signal transduction include receptors for LPA (Lysophosphatidic Acid) and S-1P (Sphingosine 1-Phosphate) and certain Hormones. Besides GPCR, Itgs (Integrins) also activate Rho GTPase.
peptidase, protease, proteolytic enzyme. 1  caspase - any of a group of proteases that mediate apoptosis. 2  enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions. angiotensin converting enzyme, angiotensin-converting enzyme, ACE - proteolytic enzyme that converts angiotensin I into angiotensin II.