Here is a breakdown of the source code representation of a Java class. A class can be broken down into two things: 1  The first piece is a class-header which consists of the keyword  class  and the name you give to the class. 2  Names in programming languages are also known as identifiers. 3  The second piece is the body.
The long isoform consists of 1162 amino acids and is the only Leptin receptor isoform with clearly demonstrated signaling capability [1]. Leptin signaling occurs typically through the JAK/STAT pathway. Janus kinase 2 (JAK2) activation leads to tyrosine phosphorylation of Leptin receptor. Phosphorylated Tyr1138 of Leptin receptor serves as a binding site for STAT proteins.
The endoplasmic reticulum (ER) resident PKR-like kinase (PERK) is necessary for Akt activation in response to ER stress. We demonstrate that PERK harbors intrinsic lipid kinase, favoring diacylglycerol (DAG) as a substrate and generating phosphatidic acid (PA). This activity of PERK correlates with activation of mTOR and phosphorylation of Akt on Ser473. PERK lipid kinase activity is regulated in a phosphatidylinositol 3-kinase (PI3K) p85Î±-dependent manner. Moreover, PERK activity is essential during adipocyte differentiation.