Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
Use the common 4-point GPA scale to assign the values: A = 4 points, B = 3 points, C = 2 points, D = 1 point, and F = 0 points. 1  If your school allots 5 points for upper level classes, such as Advanced Placement (AP) or International Baccalaureate (IB), you will be using a weighted GPA scale. For example, if you made a B in a 4 credit hour class, you would multiply the scale value of 3 for the B by 4 credit hours, which gives you 12 grade points for that class. 2  Add the weighted grade points for all of your classes together to calculate your total grade points.