Here is a breakdown of the source code representation of a Java class. A class can be broken down into two things: 1  The first piece is a class-header which consists of the keyword  class  and the name you give to the class. 2  Names in programming languages are also known as identifiers. 3  The second piece is the body.
The long isoform consists of 1162 amino acids and is the only Leptin receptor isoform with clearly demonstrated signaling capability [1]. Leptin signaling occurs typically through the JAK/STAT pathway. Janus kinase 2 (JAK2) activation leads to tyrosine phosphorylation of Leptin receptor. Phosphorylated Tyr1138 of Leptin receptor serves as a binding site for STAT proteins.
Leptin as an immune mediator[edit] Would be happy to put my 2 cents. Leptin is a potent stimulator of the immune system. Leptin receptors on monocytes cause the release intracellularly of STAT3 which cause the monocytes to release IL-6, IL-12 and TNF alpha. The IL-6 goes to the liver and increases production of CRP. All of these cytokines are elevated in obesity because of increased leptin levels.