When people say that something really gets my goat,â they mean that they are extremely irritated. A wide variety of things could contribute to irritation, ranging from someone else's actions to a series of events, but, despite the turn of phrase, goats are not usually involved.
The major activator of Rho family GTPase is GPCR (G-Protein coupled Receptor). GPCRs that activate Rho and use G-Alpha12 or G-Alpha13 for signal transduction include receptors for LPA (Lysophosphatidic Acid) and S-1P (Sphingosine 1-Phosphate) and certain Hormones. Besides GPCR, Itgs (Integrins) also activate Rho GTPase.
This article refers to the anti-tumor molecule, and not the a2iib3 integrin activation specific antibody of the same name. PAC-1 (first procaspase activating compound) is a synthesized chemical compound that selectively induces apoptosis, in cancerous cells. It was granted orphan drug status by the FDA in 2016.