Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
â¢ Unweighted GPA is on a scale of 1-4 whereas weighted GPA is on a scale of 1-5. â¢ Extra credits are given in a weighted course as it may be more difficult or advanced than an un-weighted course.