Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
By assigning greater value to grades earned in more challenging courses, weighted grades remove a potential disincentive posed by tougher coursesâi.e., students worrying that a lower grade in a tougher course might adversely affect their GPA or class rank.