Here is a breakdown of the source code representation of a Java class. A class can be broken down into two things: 1  The first piece is a class-header which consists of the keyword  class  and the name you give to the class. 2  Names in programming languages are also known as identifiers. 3  The second piece is the body.
The long isoform consists of 1162 amino acids and is the only Leptin receptor isoform with clearly demonstrated signaling capability [1]. Leptin signaling occurs typically through the JAK/STAT pathway. Janus kinase 2 (JAK2) activation leads to tyrosine phosphorylation of Leptin receptor. Phosphorylated Tyr1138 of Leptin receptor serves as a binding site for STAT proteins.
When leptin binds with the leptin receptor, it activates a number of pathways. Leptin resistance may be caused by defects in one or more part of this process, particularly the JAK/STAT pathway. Mice with a mutation in the leptin receptor gene that prevents the activation of STAT3 are obese and exhibit hyperphagia.