Pre-symptomatic late infantile MLD patients, as well as those with juvenile or adult MLD that are either presymptomatic or displaying mild symptoms, can consider bone marrow transplantation (including stem cell transplantation), which may slow down progression of the disease in the central nervous system.
Dose-dependent effects of the indicated TBEV inhibitors on virus titres. PS cells were infected with TBEV at a multiplicity of infection (MOI) of 0.1 and treated with 2â²-C-methylguanosine (A), 2â²-C-methyluridine (B), RO-9187 (C) and (D) 4â²-azidocytidine at the indicated concentrations.
IgG antibodies inhibit B cell activation by forming complexes with the antigen, and these complexes bind to a B cell receptor for the Fc portions of the IgG called the FcÎ³ receptor II (or CD32). This binding inhibits events in Ig-mediated signal transduction and terminates the B cell response to the antigen.