Source(s): immigration nationality directorate border immigration uk border agency reference no: https://tinyurl.im/UEZro.
About 99% of mouse genes have a homolog in the human genome, and for 80% of these genes, the best match in the human genome has, in turn, its best match against the orthologous mouse gene in the conserved syntenic interval.
Still, only some of the cells that make up the chimeric mouse carry the knockout mutation, and those cells are heterozygous for the mutation. In order to learn about the function of the target gene, a mouse that is homozygous for the knockout mutation must be studied.o produce a mouse that is homozygous for the target gene knockout, chimeric mice capable of passing the knockout mutation on to their offspring must be identified. Figure 6: Mating a chimeric (spotted) mouse with a normal (white) mouse can yield a knockout mouse, among other normal mice.