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What causes a fistula? After an abscess has been drained, a passage may remain between the anal gland and the skin, resulting in a fistula. If the gland does not heal, there will be persistent drainage through this passage. If the outside opening of the fistula heals first, a recurrent abscess may develop.
A gastrointestinal fistula is an abnormal opening that allows the contents of the stomach or intestines to leak. 1  If it leaks through to a part of the intestines, it is called an entero-enteral fistula. 2  If it leaks to through to the skin, it is called an enterocutaneous fistula.ack to Top Causes. Most gastrointestinal fistulas occur after surgery. Other causes include: 1  Gastrointestinal obstruction. 2  Inflammatory processes, such as infection or inflammatory bowel disease (most often Crohn's disease).