The Shinnston News & Harrison County Journal. WV DOH News-Road Closure: The WV DOH advises motorists that Wednesday, September 5th, Harrison County Route 14-Little Rock Camp Road will be closed due to a culvert replacement. The hours for this closure are from 8:00am to 5:00pm.
Cysteine residues in homologous proteins (those of common ancestry) are very conservative according to PAM 250 scoring matrix . Only Trp is statistically more conservative than Cys. Fig 4. PAM 250 scoring matrix of Dayhoff mutation data matrix. Note that the highest values indicating replacement of a residue into itself is for Trp and Cys. That means the two residues are the most conservative in homologous sequences. The reason is that cysteine - because of disulfide bridges - plays very important role in stabilization of protein structure at higher level.
Covalent bonds are the strongest chemical bonds contributing to protein structure. Covalent bonds arise when two atoms share electrons. In addition to the covalent bonds that connect the atoms of a single amino acid and the covalent peptide bond that links amino acids in a protein chain, covalent bonds between cysteine side chains can be important determinants of protein structure. Cysteine is the sole amino acid whose side chain can form covalent bonds, yielding disulfide bridges with other cysteine side chains: --CH 2-S-S-CH 2-- .