Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
A: Simply follow the steps below to calculate your weighted GPA. 1  Step 1: convert every letter grade to their respective points (A=4, B=3, C=2, D=1, F=0). 2  Step 2: Add up all the grade points. 3  Step 3: Divide the added grade points (step 2) by the number of class credits taken.