Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
1. Multiply each number by its weight. 1  You can choose to write this at the end of the chart or to do it on 1 line, in a formula. 2  For example, if you are trying to figure out the weighted average of certain grades, you might write 0.9(0.25) to indicate a 90 percent grade times 25 percent of the total grade. weighted average is a more accurate measurement of scores or investments that are of relative importance to each other.