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According to The Pill Book Guide to Medication For Your Dog and Cat (Kate A.W. Roby, VMD, et al, 1998), cats are started off at 1 mg of prednisone per pound that the cat weighs. This is given one or two times a day. When the cat seems better, one dose is given every other day until the cat is cured.
Administration. Buspirone is available in tablet form. Your vet might prescribe a 5 milligram pill twice a day for the first week. If you don't see a response, your vet might up the dosage to 7.5 milligrams twice daily for a week. If your cat still isn't responding, it's likely buspirone isn't the drug for him. However, if the larger dose does generate less inappropriate elimination, your vet might wean your cat back to the 5 milligram dose twice a day for a week.