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Physiological and pathological changes are main inducing factors of diminished kidney function, which includes trauma, infection, inflammation, immune response, blood circulatory disorder, etc.
There are a number of reasons for enlarged kidneys, from polycystic kidney disease to infections, alcoholism and cancer. Enlarged kidneys may be discovered when doctors treat symptoms or as part of a prostrate or pelvic exam. Enlarged kidneys may be congenital, but this condition is rare. Other causes may be cysts, PKD, tumors, urine reflux,hydronephrosis due to kidney stones, etc.