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A gene mutation is a permanent alteration in the DNA sequence that makes up a gene, such that the sequence differs from what is found in most people.Mutations range in size; they can affect anywhere from a single DNA building block (base pair) to a large segment of a chromosome that includes multiple genes. gene mutation is a permanent alteration in the DNA sequence that makes up a gene, such that the sequence differs from what is found in most people.
Rating Newest Oldest. Best Answer: A gene mutation is a permanent change in the DNA sequence that makes up a gene. Mutations range in size from a single DNA building block (DNA base) to a large segment of a chromosome.A chromosomal mutation is a mutation involving a long segment of DNA, it is a any change in the structure or arrangement of the chromosomes.he mutation is called the C677T.People with two copies of the T mutation are two and a half times as likely to have a NTD as people with two copies of the normal gene.