Pre-symptomatic late infantile MLD patients, as well as those with juvenile or adult MLD that are either presymptomatic or displaying mild symptoms, can consider bone marrow transplantation (including stem cell transplantation), which may slow down progression of the disease in the central nervous system.
Dose-dependent effects of the indicated TBEV inhibitors on virus titres. PS cells were infected with TBEV at a multiplicity of infection (MOI) of 0.1 and treated with 2â²-C-methylguanosine (A), 2â²-C-methyluridine (B), RO-9187 (C) and (D) 4â²-azidocytidine at the indicated concentrations.
Cell cycle stage can determine the susceptibility of T cells to death stimuli such as Fas ligation 26 and CD3 cross-linking. 28 However, we have determined that cell cycle stage does not effect the susceptibility of T cells to galectin-1-induced death.