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A gene mutation is a permanent alteration in the DNA sequence that makes up a gene, such that the sequence differs from what is found in most people.Mutations range in size; they can affect anywhere from a single DNA building block (base pair) to a large segment of a chromosome that includes multiple genes. gene mutation is a permanent alteration in the DNA sequence that makes up a gene, such that the sequence differs from what is found in most people.
Gene mutation may lead to alter the number or the structure of the entire chromosome, which could lead to chromosomal mutations. However, gene mutations are small-scale alterations in the nucleotide sequence and those are sometimes corrected through gene regulatory mechanisms but sometimes not.ome of the problems that are evident of a gene mutation cause are the sickle cell anaemia and lactose intolerance. Chromosome Mutation. Chromosome mutation is a large-scale alteration of the chromosomes of an organism, where either the number or the structure of chromosomes is changed.