Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
College prep courses are not weighted, so your gpa, both weighted and unweighted, is a 3.34. The only way to get above a 4.0 is to take either honors or AP classes. AP classes are college-level, and if you get a decent grade on the AP exam in May you could earn college credits.   Honors classes are just an advanced version of the â¦ College Prep classes.