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Physiological and pathological changes are main inducing factors of diminished kidney function, which includes trauma, infection, inflammation, immune response, blood circulatory disorder, etc.
Kidney damage and decreased function that lasts longer than 3 months is called chronic kidney disease (CKD). Chronic kidney disease is particularly dangerous, because you may not have any symptoms until considerable, often irreparable, kidney damage has occurred. Diabetes (types 1 and 2) and high blood pressure are the most common causes of CKD. Other causes are: