When people say that something really gets my goat,â they mean that they are extremely irritated. A wide variety of things could contribute to irritation, ranging from someone else's actions to a series of events, but, despite the turn of phrase, goats are not usually involved.
The major activator of Rho family GTPase is GPCR (G-Protein coupled Receptor). GPCRs that activate Rho and use G-Alpha12 or G-Alpha13 for signal transduction include receptors for LPA (Lysophosphatidic Acid) and S-1P (Sphingosine 1-Phosphate) and certain Hormones. Besides GPCR, Itgs (Integrins) also activate Rho GTPase.
GT is the abbreviation for Grand Tourer which comes from the Italian tradition of referring to luxury performance cars as Grand Turismo. Generally it is a high performance and luxurious automobile capable of high spirited long-distance performance driving. The most common format is a two-door coupe with either a two or four seats.