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Physiological and pathological changes are main inducing factors of diminished kidney function, which includes trauma, infection, inflammation, immune response, blood circulatory disorder, etc.
Prerenal Causes of AKI. The kidney tissues need oxygen, carried in the blood, to function normally. Prerenal causes of decreased kidney function result from decreased blood flow to the kidney. This is the most common cause of AKI. In most cases, the kidneys are normal. but the function is impaired due to reduced blood flow. A few examples of causes include: -- Dehydration caused by diarrhea, vomiting or excessive sweating.