Plate tectonics is the theory that Earth's outer shell is divided into several plates that glide over the mantle. Plate tectonics is the theory that Earth's outer shell is divided into several plates that glide over the mantle.
The term âfutilityâ is used to refer to the inability of a clinical trial to achieve its objectives. In particular, stopping a clinical trial when the interim results suggest that it is unlikely to achieve statistical significance can save resources that could be used on more promising research.
When overall survival is the primary outcome and events accrue slowly, and if a suitable intermediate endpoint is available, then using this endpoint for interim futility testing may yield a higher probability of stopping early for futility in the absence of any treatment effect.