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PREPARATIONS: Polymyxin B sulfate/trimethoprim is a sterile eye drop, containing polymyxin B sulfate 10,000 units/ml and trimethoprim sulfate 1 mg/ml, available in 10 ml dispenser bottles. DRUG INTERACTIONS: Drug interactions have not been established for polymyxin B sulfate/trimethoprim combination eye drops.
Trimethoprim-sulfamethoxazole (TMP-SMX) has been demonstrated to be effective for prophylaxis against PCP for children with cancer and for adults with HIV infection. It is systemically active against Pneumocystis carinii, and there is longstanding experience with the drug for prophylaxis for children.