Actinic keratoses that develop on the lips are referred to as actinic cheilitis. The clinical appearance of an actinic keratosis is that of a small (several millimeters), red scaly papule or plaque, with induration and thickening of the epidermis. There may be associated erythema.
Blood Clots. A blood clot needs to be considered as a cause of calf pain, especially when the calf pain is not the immediate result of an injury. Blood clots can form is the deep veins of the leg, causing a blockage in circulation. This may cause swelling and pain in the calf.
Sudden onset of swelling in one leg accompanied by pain in your calf muscle can be due to a blood clot (deep vein thrombosis, or DVT) in one of your leg veins. If this occurs, seek medical help immediately. Inadequate lymphatic system. Your body's lymphatic system helps clear excess fluid from tissues. If this system is damaged â for example, by cancer surgery â the lymph nodes and lymph vessels draining an area may not work correctly, and edema can occur. Severe, long-term protein deficiency.