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As with other thyroid-related problems, nodules are more common in women than men and the risk in both sexes increases with age. Most thyroid nodules do not cause any symptoms. However, if they grow large enough, they can cause swelling in the neck and lead to breathing and swallowing difficulties, pain, and goiter.
Rarely, severe thyroid hormone deficiency can cause coma, low body temperature, and even death. LH and FSH deficiency in Women : LH and FSH deficiency may cause loss of menstrual cycles, infertility, decrease in sex drive and vaginal dryness and osteoporosis, which can result in a tendency to develop bone fractures.