Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
A 4.0 out of 4.0 is great, but a 4.0 out of 5.0 isn't so great. If your school weights grades based on what courses you're taking, then every student has a GPA on a different scale. If the AP classes are weighted 1 point, and you're taking all AP classes, then your GPA is out of 5.0. just now. Report Abuse. The highest grade on a 4.0 scale is 4.0. However, your high school apparently weights grades, so that's why they come out above 4.0. This is why colleges ask for unweighted grades-because every school does it differently. Therefore, your GPA only makes sense if you state which scale it's on.