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Physiological and pathological changes are main inducing factors of diminished kidney function, which includes trauma, infection, inflammation, immune response, blood circulatory disorder, etc.
Diabetes is the most common cause of ESRD. High blood pressure is the second most common cause of ESRD. Sometimes the kidneys can stop working very suddenly (within two days). This type of kidney failure is called acute kidney injury or acute renal failure. This type of kidney failure is not always permanent.