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At a basic level, Gluconeogensis is an anabolic process. It involves the creation of a 6 carbon glucose molecule from smaller precursors. The name gluco (glucose) neo (new) genesis (creation) is quite descriptive of what the pathway does. Ana-bolic is greek for upward-throw.
1 The final reaction of gluconeogenesis, the formation of glucose, occurs in the lumen of the endoplasmic reticulum, where glucose-6-phosphate is hydrolyzed by glucose-6-phosphatase to produce glucose and release an inorganic phosphate.he liver uses primarily lactate, alanine and glycerol while the kidney uses lactate, glutamine and glycerol. Propionate is the principal substrate for gluconeogenesis in the ruminant liver, and the ruminant liver may make increased use of gluconeogenic amino acids, e.g. alanine, when glucose demand is increased.