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As with other thyroid-related problems, nodules are more common in women than men and the risk in both sexes increases with age. Most thyroid nodules do not cause any symptoms. However, if they grow large enough, they can cause swelling in the neck and lead to breathing and swallowing difficulties, pain, and goiter.
Hypothyroidism results from reduced effects of thyroid hormone on tissues. Hypothyroidism is more common in women and has a total prevalence of 1% to 2%, increasing with age (~10% adults >65 years).