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Physiological and pathological changes are main inducing factors of diminished kidney function, which includes trauma, infection, inflammation, immune response, blood circulatory disorder, etc.
While in some cases, enlarged kidney may not be associated with any apparent cause, there are some common causes that have been identified, 1  Vesicoureteral reflux: This condition is associated with faulty functioning of the valves which are present at the juncture of the ureters and the urinary bladder.