Actinic keratoses that develop on the lips are referred to as actinic cheilitis. The clinical appearance of an actinic keratosis is that of a small (several millimeters), red scaly papule or plaque, with induration and thickening of the epidermis. There may be associated erythema.
Blood Clots. A blood clot needs to be considered as a cause of calf pain, especially when the calf pain is not the immediate result of an injury. Blood clots can form is the deep veins of the leg, causing a blockage in circulation. This may cause swelling and pain in the calf.
An abnormal buildup of fluid in tissues called edema is what causes swelling in the legs. In some cases, edema that results in painful swollen legs and ankles can be caused by lymphatic dysfunction. In other cases, edema can result from long-standing venous reflux, a venous disease that causes spider veins and varicose veins and can lead to more serious conditions, such as skin discoloration or venous ulcers.