Forces That Drive Tertiary Structure. Most proteins fold into their tertiary structure in an aqueous environment-a cell is, after all, 60% water. The chemical properties of the various R-groups (sidechains) of the amino acids within the protein chain will influence the way that the protein folds in its environment.
This cold sensation will last approximately three to five minutes until a burning sensation appears. The burning sensation will fade into an ache, followed by numbness. Beware that once numbing occurs, remove and discontinue the ice. Continued application following numbing may result in tissue damage.
To avoid getting an ice burn, there are several precautions to take with ice therapy: 1  When applying ice directly to the skin on the back, be sure to keep the ice moving in a slow, circular motion to avoid staying in one place too long. 2  Limit the ice massage to no more than five minutes at a time.