Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
A true A in an Advanced Placement class is obviously more impressive than a weighted A.. The issue of weighting grades gets even more complicated since many high schools weight grades, but others don't. And colleges may calculate a GPA that is different from a student's weighted or unweighted GPA. This is particularly true for highly selective colleges and universities, for the great majority of applicants will have taken challenging AP, IB, and Honors courses.