When people say that something really gets my goat,â they mean that they are extremely irritated. A wide variety of things could contribute to irritation, ranging from someone else's actions to a series of events, but, despite the turn of phrase, goats are not usually involved.
The major activator of Rho family GTPase is GPCR (G-Protein coupled Receptor). GPCRs that activate Rho and use G-Alpha12 or G-Alpha13 for signal transduction include receptors for LPA (Lysophosphatidic Acid) and S-1P (Sphingosine 1-Phosphate) and certain Hormones. Besides GPCR, Itgs (Integrins) also activate Rho GTPase.
Virulence factors dealing in the role of GTPases [edit]. A major group of virulence factors are proteins that can control the activation levels of GTPases. There are two ways in which they act. One is by acting as a GEF or GAP, and proceeding to look like a normally eukaryotic cellular protein.The other is covalently modifying the GTPase itself.hese obtained bacterial virulence factors have two different routes used to help them survive and grow: 1  The factors are used to assist and promote colonization of the host. 2  The factors, including toxins, hemolysins, and proteases, bring damage to the host.