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Physiological and pathological changes are main inducing factors of diminished kidney function, which includes trauma, infection, inflammation, immune response, blood circulatory disorder, etc.
1 End stage renal disease (ESRD): Complete loss of kidney function, usually due to progressive chronic kidney disease. 2  People with ESRD require regular dialysis for survival. 3  Papillary necrosis: Severe damage to the kidneys can cause chunks of kidney tissue to break off internally and clog the kidneys.