The following books and articles on Hawk's Nest Tunnel Disaster can be found at the West Virginia Archives and History Library. BOOKS. Cherniack, Martin. The Hawk's Nest Incident; America's Worst Industrial Disaster. New Haven, Connecticut, Yale University Press, 1986. 363.179 C521.
There are three different types of myofilaments: thick, thin, and elastic filaments. Thick filaments consist primarily of the protein myosin. Each thick filament is approximately 15 nm in diameter, and each is made of several hundred molecules of myosin. A myosin molecule is shaped like a golf club, with a tail formed of two intertwined chains and a double globular head projecting from it at an angle.
The binding of the myosin heads to the muscle actin is a highly regulated process. The thin filament is made of actin, tropomyosin, and troponin. The contraction of skeletal muscle is triggered by nerve impulses that in turn stimulate the release of Ca 2+ .The release of Ca 2+ from the sarcoplasmic reticulum causes an increase in the concentration of Ca 2+ in the cytosol.ropomyosins are often categorised into two groups, muscle tropomyosin isoforms and nonmuscle tropomyosin isoforms. Muscle tropomyosin isoforms are involved in regulating interactions between actin and myosin in the muscle sarcomere and play a pivotal role in regulated muscle contraction.