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Hypertrichosis can be congenital or acquired. The acquired condition is usually caused by an illness or drugs. Illnesses that might cause this condition are hypothyroidism, malnutrition, AIDS, dermatomyositis (a connective tissue disease), and porphyria cutanea tarda (a condition involving enzymes).
The real cause of werewolf syndrome remains unclear. Although it was observed that genetic mutations play an important role to the development of this condition. Besides, werewolf syndrome is associated to cancer-related condition which happens after the person had cancer while certain drugs and metabolic disorders will result to hypertrichosis. Furthermore, untreated infection and malnutrition are other contributing factors in the development of hypertrichosis.