Itai-itai disease (ã¤ã¿ã¤ã¤ã¿ã¤ç, itai-itai byÅ? ), (literally: ouch-ouch disease) was the first documented case of mass cadmium poisoning in the world in Toyama Prefecture, Japan in 1950. The cadmium poisoning caused softening of the bones and kidney failures.
Weighted grades are number or letter grades that are assigned a numerical advantage when calculating a grade point average, or GPA.
First off, you should know what constitutes weighted and unweighted GPA in high school. Traditional GPAs are unweighted, which means they're measured on a scale of 0 to 4.0. A 4.0 is an A average, a 3.0 is a B average, a 2.0 is a C average, a 1.0 is a D average, and anything below that represents a failing grade. Unweighted GPAs do not take the levels of your classes into account. An A in an AP or Honors class will translate into a 4.0 GPA, and so will an A in a low-level class. An unweighted GPA wonât change based on the types of classes youâre taking; it represents your grades in isolation. Weighted GPAs are a bit more complicated.