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Physiological and pathological changes are main inducing factors of diminished kidney function, which includes trauma, infection, inflammation, immune response, blood circulatory disorder, etc.
What are the causes of fatigue in kidney disease? Anemia In right condition, healthy kidneys can produce enough red blood cells to transport blood. However, when kidneys are damaged, there will be shortage of EPO, in this case, anemia is more likely to occur. And anemia is often regarded as the major cause of fatigue.