In women, premature delivery, insulin-dependent diabetes mellitus (IDDM),4 obesity, Cesarean section and endocrine disturbances can either delay or suppress lactogenesis II and affect the successful establishment of lactation (18).
third spacing is a shift of fluid into the interstitial spaces--where there is little fluid normally perfusing. this patient differs from the pt with generalized edema because the third spacing is just that... all the fluid has shifted from the other compartments and although they look all puffy and full of fluid, they are actually hypovolemic.
Interstitial fluid. Interstitial fluid (ISF) or tissue fluid is a solution that bathes and surrounds the tissue cells of multicellular animals. It is the main component of the extracellular fluid, which also includes plasma and transcellular fluid. The interstitial fluid is found in the interstices - the spaces between cells (also known as the tissue spaces).