Forces That Drive Tertiary Structure. Most proteins fold into their tertiary structure in an aqueous environment-a cell is, after all, 60% water. The chemical properties of the various R-groups (sidechains) of the amino acids within the protein chain will influence the way that the protein folds in its environment.
This cold sensation will last approximately three to five minutes until a burning sensation appears. The burning sensation will fade into an ache, followed by numbness. Beware that once numbing occurs, remove and discontinue the ice. Continued application following numbing may result in tissue damage.
1 If the inflammation is in smaller, more exposed tendons / muscles (such as the wrist or elbow), then apply the ice for about 10 minutes. 2  If it's a larger or deeper tendon / muscle (such as the shoulder or hip), then leave the ice on for closer to 20 minutes.