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Botox is remarkably safe, especially considering it's a powerful toxin. Occasionally, a mild headache that lasts a few hours may occur after an injection in muscles of the forehead. Very rarely, though, that headache may become excruciating and can last as long as a month.
In clinical trials, BOTOXÂ® provided a significant reduction in headache days after the first treatment. After the second treatment (at 24 weeks), BOTOXÂ® prevented 8 to 9 headache days a month (vs 6 to 7 for placebo). You may start to feel results as early as 4 weeks. Over the course of 2 treatment sessions, you should notice a reduction in headache days.