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Botox is remarkably safe, especially considering it's a powerful toxin. Occasionally, a mild headache that lasts a few hours may occur after an injection in muscles of the forehead. Very rarely, though, that headache may become excruciating and can last as long as a month.
People who get migraines or chronic headaches that last for at least four hours and occur 15 or more days out of the month may be recommended for Botox treatment. In most cases, patients who have chosen to receive the injections experience dramatic relief.