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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
Common L-Arginine Side Effects. L-Arginine is a natural substance found in food, and has no side effects when it is consumed. However, taking it in a supplemental form can cause problems in some people. Generally these side effects are not serious, ranging from mildly annoying to discomfort. In some instances, though, taking L-Arginine is dangerous and can be life threatening.