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terminator codon mutations and hypofunctional genes responsible for various Î±-thalassemia syndromes [6]. Î±-thalassemia can be suspected based on factors such as a family history of anemia and ethnic and geographic backgrounds, particularly if the patients
Causes Thalassemia is caused by mutations in the DNA of cells that make hemoglobin â the substance in your red blood cells that ... The mutations that cause thalassemia disrupt the normal production of hemoglobin and cause low hemoglobin levels and a high rate of red ... A lower-than-normal red blood cell count can have many causes, including: anemia; bone marrow failure; kidney disease causing a deficiency of ...