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Layers of the Heart Wall. The wall of the heart consists of three layers: the epicardium (external layer), the myocardium (middle layer) and the endocardium (inner layer). The epicardium is the thin, transparent outer layer of the wall and is composed of delicate connective tissue.
The endocardium is the most inner layer of the heart. It forms the inner layer of all four heart chambers and is directly connected to all the inner cardiac appendages, such as the bicuspid valve, the tricuspid valve, the pulmonary valve, the aortic valve, the chordae tendineae and the papillary muscles.he epicardium is the layer of muscle found covering the external surfaces of the heart. It is directly fused with the myocardium internally and is in contact with the serous layer of the pericardium. It is sometimes considered as a division of the inner layer of the pericardium.