All cells require folic acid and it can diffuse easily into human cells. But the vitamin cannot enter bacterial cells and thus bacteria must make their own. The sulfa drugs such as sulfonamides inhibit a critical enzyme--dihydropteroate synthase--in this process. Once the process is stopped, the bacteria can no longer grow.
Sonoma Countyâs natural beauty and moderate temperatures seldom dip below freezing, even in the winter. The areaâs 25- to 30-inch annual rainfall happens primarily from November through April. January â Average high /low. Inland: 58 F (14 C) / 36 F (2 C) Coast: 56 F (13 C) / 35 F (2 C)
0am:The Coloma, CA forecast for Mar 21 is 38 degrees and Light drizzle. There is 83 percentage chance of rain and 3 mph winds from the West. 3am:The Coloma, CA forecast for Mar 21 is 37 degrees and Patchy rain possible. There is 88 percentage chance of rain and 2 mph winds from the West-Northwest.