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Botox is remarkably safe, especially considering it's a powerful toxin. Occasionally, a mild headache that lasts a few hours may occur after an injection in muscles of the forehead. Very rarely, though, that headache may become excruciating and can last as long as a month.
Botox is not the go-to treatment for migraineurs. Itâs usually considered after having had poor results with other migraine treatments (for example, at least two prescription medications, from two separate medication classes).