Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to Î¼-opioid receptors. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in Î¼-opioid binding.
Marilyn vos Savant. Marilyn vos Savant has a verified IQ of 190. In 1985, The Guinness Book of World Records accepted vos Savantâs IQ score of 190, and according to marilynvossavant.com, crowned her the woman with the highest IQ for five consecutive years â she has tested as high as 228 on various IQ tests.
6. Marilyn Vos Savant Born in 1946 in St. Louis, Missouri, Savant is a columnist, author, and playwright who made it to the pinnacle of fame by getting listed five times in the Guinness Book of World Records as the woman with the highest IQ ever recorded (verified at 190) from 1986 to 1989.ith a verified IQ of 210, Korean civil engineer Ung-Yong had his name etched once in the Guinness Book of World Record under its âHighest IQâ category.