The only antidepressant with a half-life substantially in excess of 24 hours is fluoxetine. The parent drug has a half-life of 2 to 4 days and norfluoxetine, its active metabolite, has a half-life of 7 to 15 days. This half-life is even longer at doses above 20 mg/day in physically healthy older patients.
Toxic shock syndrome, or TSS, is a very rare and life-threatening bacterial infection. Some women can be affected by toxic shock syndrome from certain types of tampon, but men and children can also get TSS. Toxic shock syndrome can also be caused by boils, insect bites, scalds, burns or other wounds being infected by Staphylococcus aureus and Streptococcus pyogenes bacteria.
An infection caused by strep or staph bacteria can lead to toxic shock syndrome. These bacteria are common and usually don't cause problems. But in rare cases, the toxins enter the bloodstream and cause a severe immune reaction. This reaction causes the symptoms of TSS. Toxic shock syndrome caused by strep most often occurs after childbirth, the flu (influenza), chickenpox, surgery, minor skin cuts or wounds, or injuries that cause bruising but may not break the skin.