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Researchers do know from twin studies that genetics plays a role in personality disorders. Environmental factors, such as childhood abuse, neglect and separation from caregivers, as well as brain abnormalities, emotion regulation, impulsivity, aggression and serotonin levels all play a role.ecause many personality domains are heritable, borderline personality disorder may be a result of a genotype interacting with adverse environmental factors. This would in turn lead to the expression of borderline symptoms or other dysfunctional personality traits.
The LMNA gene normally makes a protein called lamin A,which is an important protein for most cells of our bodies. Lamin A is foundin the cell nucleus (the part of each cell that contains the DNA) and helpsmaintain the shape and function of the cell. In Progeria, the LMNA mutation causes the gene to produce an abnormalLamin A protein called progerin. In children with Progeria, many cells in thebody â such as the blood vessels, skin, and bones â make progerin protein.As the children age, progerin builds up in these cells causing progressivedisease.