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terminator codon mutations and hypofunctional genes responsible for various Î±-thalassemia syndromes [6]. Î±-thalassemia can be suspected based on factors such as a family history of anemia and ethnic and geographic backgrounds, particularly if the patients
You need four genes (two from each parent) to make enough alpha globin protein chains. If one or more of the genes is missing, you'll have alpha thalassemia trait or disease. This means that your body doesn't make enough alpha globin protein. If you're missing two genes, you have alpha thalassemia trait (also called alpha thalassemia minor). 2  You may have mild anemia. 3  If you're missing three genes, you likely have hemoglobin H disease (which a blood test can detect). 4  This form of thalassemia causes moderate to severe anemia.