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The hypothalamus is located on the undersurface of the brain. It lies just below the thalamus and above the pituitary gland, to which it is attached by a stalk. It is an extremely complex part of the brain containing many regions with highly specialised functions. In humans, the hypothalamus is approximately the size of a pea and accounts for less than 1% of the weight of the brain.
The Hypothalamus and the Pituitary Gland. The hypothalamus is the region of the brain that controls hormone release, and is thus part of the neuroendocrine system. The pituitary gland is closely allied with the hypothalamus, both functionally and physically.Some hypothalamic neurons project directly to the neural lobe of the pituitary.Others project to the median eminence, where they connect with blood vessels that supply the pituitary.he pituitary gland is closely allied with the hypothalamus, both functionally and physically. Some hypothalamic neurons project directly to the neural lobe of the pituitary. Others project to the median eminence, where they connect with blood vessels that supply the pituitary.