Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to Î¼-opioid receptors. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in Î¼-opioid binding.
Marilyn vos Savant. Marilyn vos Savant has a verified IQ of 190. In 1985, The Guinness Book of World Records accepted vos Savantâs IQ score of 190, and according to marilynvossavant.com, crowned her the woman with the highest IQ for five consecutive years â she has tested as high as 228 on various IQ tests.
Sexy Katrin Davidsdottir Named âFittest Woman On Earth,â Can Probably Kick Your Ass In The Gym. Katrin Davidsdottir goes hard in the gym. Like insanely all-out in her workouts. But itâs her intense dedication that has her named as the âFittest Woman on Earthâ after winning the 2015 Reebok CrossFit Games in Los Angeles last week. The ridiculously fit Katrin hails from Iceland, where they seemingly pick beastly humans like HafÃ¾Ã³r JÃºlÃ­us BjÃ¶rnsson on trees or geysers or something.