Terminal illness is a disease that cannot be cured or adequately treated and that is reasonably expected to result in the death of the patient within a short period of time.he six-month standard is arbitrary, and best available estimates of longevity may be incorrect. Consequently, though a given patient may properly be considered terminal, this is not a guarantee that the patient will die within six months.
1 Stop metformin if the eGFR is below 30 ml/minute/1.73m2.  Prescribe metformin with caution for those at risk of a sudden deterioration in kidney function and those at risk of eGFR falling below 45ml/minute/1.73m2.
Symptoms of lactic acidosis include weakness, sleepiness, slow heart beat, feeling cold, muscle pain, shortness of breath, loss of consciousness, etc. Although metformin does not directly cause kidney damage, the patients who have kidney damage and or kidney disease should not use the medicine. Another significant complication of metformin is Acute Kidney Failure. Gastrointestinal problems such as, significant diarrhea or vomiting commonly occur in people who are taking metformin therapy when there is underlying chronic kidney disease. It can lead to severe dehydration and acute renal failure.