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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
Dosage, length of use and when to take L-arginine will differ based on use and health status. Duration: According to WebMD, clinical trials indicate arginine can be safely used with only a few minor side effects for up to three months. Some of the minor side effects include bloating, diarrhea and abdominal pain.