Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to Î¼-opioid receptors. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in Î¼-opioid binding.
Marilyn vos Savant. Marilyn vos Savant has a verified IQ of 190. In 1985, The Guinness Book of World Records accepted vos Savantâs IQ score of 190, and according to marilynvossavant.com, crowned her the woman with the highest IQ for five consecutive years â she has tested as high as 228 on various IQ tests.
That Depends on what subject you want. Recently I read in a magazine about the intelligent woman in the history. She is a columnist and an author. She was named in Guinnes Book of World records for having an IQ of 228. She is a scientist and in 2008 at the age of 28 she became the youngest person to receive a financial engineering Ph.D. magna cum laude.