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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
It can take 2-3 weeks for sertraline to start helping. It takes 2-3 weeks for sertraline to show its full effect. We do not know why. 1  Scientists believe that at first the higher level of serotonin feeds back to the brain that it should make less of it (this means you do not feel any better).