Juxtaposition is defined as the act of placing two things side by side for comparison. An example of a juxtaposition is the placing of baby blue and sky blue next to each other to see how they differ. noun. The act or an instance of juxtaposing or the state of being juxtaposed.
And then they become mutations, which may eventually lead to cancer. This is especially true if the mutation occurs in a tumor suppressor gene or oncogene. Mutations in DNA repair genes can be inherited, such as with Lynch syndrome, or acquired. Despite all that is known about the different ways cancer genes work, many cancers cannot be linked to a specific gene.
There are exceptions to the two-hit rule for tumor suppressors, such as certain mutations in the p53 gene product. p53 mutations can function as a dominant negative, meaning that a mutated p53 protein can prevent the function of normal protein from the un-mutated allele.