All cells require folic acid and it can diffuse easily into human cells. But the vitamin cannot enter bacterial cells and thus bacteria must make their own. The sulfa drugs such as sulfonamides inhibit a critical enzyme--dihydropteroate synthase--in this process. Once the process is stopped, the bacteria can no longer grow.
Sonoma Countyâs natural beauty and moderate temperatures seldom dip below freezing, even in the winter. The areaâs 25- to 30-inch annual rainfall happens primarily from November through April. January â Average high /low. Inland: 58 F (14 C) / 36 F (2 C) Coast: 56 F (13 C) / 35 F (2 C)
Tulare County, California, gets 8 inches of rain per year. The US average is 39. Snowfall is 0 inches. The average US city gets 26 inches of snow per year. The number of days with any measurable precipitation is 24. On average, there are 270 sunny days per year in Tulare County, California. The July high is around 97 degrees. The January low is 37. Sperling's comfort index for Tulare County is a 77 out of 100, where a higher score indicates a more comfortable year-around climate.