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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
The main data that generated some interest in the use of arginine for erectile dysfunction came from a small double-blind trial in which 50 men with erectile dysfunction received either 5 g of L-arginine or placebo daily for six weeks (NOTE: a capsule contains 500 mg, so 10 capsules a day!).