Terminal illness is a disease that cannot be cured or adequately treated and that is reasonably expected to result in the death of the patient within a short period of time.he six-month standard is arbitrary, and best available estimates of longevity may be incorrect. Consequently, though a given patient may properly be considered terminal, this is not a guarantee that the patient will die within six months.
1 Stop metformin if the eGFR is below 30 ml/minute/1.73m2.  Prescribe metformin with caution for those at risk of a sudden deterioration in kidney function and those at risk of eGFR falling below 45ml/minute/1.73m2.
Lactic Acidosis. Metformin may cause lactic acidosis, which is a condition caused by excessive buildup of lactic acid in the body. Symptoms of lactic acidosis include weakness, drowsiness, decreased heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, lightheadedness and fainting.