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terminator codon mutations and hypofunctional genes responsible for various Î±-thalassemia syndromes [6]. Î±-thalassemia can be suspected based on factors such as a family history of anemia and ethnic and geographic backgrounds, particularly if the patients
Hemoglobinopathies, mainly sickle cell anemia and thalassemia, are genetic blood disorders that are globally widespread, and about 5% of the worldâs population carry the genes responsible for hemoglobinopathy [1]. Thalassemia is a group of congenital disorders characterized by a deficient synthesis of both alpha (Î±) and beta (Î²) chains of hemoglobin.