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Those of us in the animal sheltering and rescue world usually recommend early-age spay/neuter at 8 weeks of age, or as soon as possible after that. Promoting early-age spay neuter is part of the social responsibility we feel to do all we can to reduce 5,000 dogs and cats euthanized in animal shelters every day. We see the number of puppies and kittens barely 6 months old that come to shelters, suffering from such an early pregnancy.
If your male cat will not be around fertile female cats, please wait until he is six months old to neuter him. But, do have him neutered at six months. There has been no correlation made between early spaying and any health problems. Females can go into heat as early as six months old, but it is very rare. As long as you have them spayed/neutered at six months, all should be well. Each vet has their own idea of exactly what age a cat should be, so you should call your local vet to find out for sure. The vet I work for says at least three months old, or weighing three pounds. We generally give the rabies vaccine at the time of the surgery, and 3lbs is the requirement for the vaccine.