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Botox is remarkably safe, especially considering it's a powerful toxin. Occasionally, a mild headache that lasts a few hours may occur after an injection in muscles of the forehead. Very rarely, though, that headache may become excruciating and can last as long as a month.
Some physicians use Botox to treat other medical conditions such as migraine headaches and nerve spasms. Botox cosmetic treatment can start to work immediately but some people do not see full effects for several days. The procedure will slowly begin to wear off after 3 or 4 months at which time you can go back for another treatment. Some patients find that after several treatments, each Botox injection may last for 6 months or more. Another benefit of how long Botox lasts is that even after it actually wears off, the skin has regenerated some and the line appearances will be less deep.