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Researchers do know from twin studies that genetics plays a role in personality disorders. Environmental factors, such as childhood abuse, neglect and separation from caregivers, as well as brain abnormalities, emotion regulation, impulsivity, aggression and serotonin levels all play a role.ecause many personality domains are heritable, borderline personality disorder may be a result of a genotype interacting with adverse environmental factors. This would in turn lead to the expression of borderline symptoms or other dysfunctional personality traits.
1 Genetics: Some research suggests that family history plays a part in increasing the likelihood that a person will develop GAD. 2  This means that the tendency to develop GAD may be passed on in families. 3  Brain chemistry: GAD has been associated with abnormal functioning of certain neurotransmitters in the brain.