The most common cause of Angelman syndrome is a deletion of the maternal chromosome region 15q11-q13, which includes the UBE3A gene. Importantly, mutations and deletions of the UBE3A gene are sufficient to cause Angelman syndrome, making UBE3A the single gene responsible for the core symptoms of the disorder. Two major deletion classes known as class I and class II deletions in the 15q11-q13 region both cause Angelman syndrome.
1 ER+/PR+: About 65% of estrogen-receptor-positive breast cancers are also progesterone-receptor-positive. 2  This means that the cells have receptors for both hormones, which could be supporting the growth of the breast cancer.
this means that estrogen but not progesterone may be supporting the growth and spread of the cancer cells er pr+ about 2 % of breast cancers are estrogen receptor negative and progesterone receptor positive this means that the hormone progesterone is likely to support the growth of this canceronly a small number of breast cancers test negative for estrogen receptors but positive for progesterone receptorshis means that the cells have receptors for both hormones which could be supporting the growth of the breast cancer er+ pr about 13 % of breast cancers are estrogen receptor positive and progesterone receptor negative