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Tramadol levels in the blood peak 2 hours after taking a 100 mg oral dose. In clinical studies, the onset of pain relief was faster with a combination formula of tramadol hydrochloride and acetaminophen (brand name Ultracet) than Tramadol alone. Onset of analgesia (pain relief) occurred in less than one hour. However, it takes 2 days to reach steady-state concentrations of Tramadol in the blood at a dosing rate of four times per day. As stated before Tramadol works differently for every person.
Answer by Ninakhan. Confidence votes 883. It usually takes 20 minutes to a half hour for medicine to work, but some medicine takes more time then others. Tramadol, for example, can take 50-55 minutes to really get rolling in the blood stream, but will usually last six hours.peaking from experience: usually it would take me about 5 days to a week after my last pain Med. Then after those days passed I took a pill and it hit me 2x as hard than it â¦ did 5 days ago or a week ago! Hope this answer helped.