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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
Any drug or supplement can cause side effects. L-arginine is no exception. L-arginine affects the way your body handles waste, so it can have adverse effects on the organs involved in waste disposal. Some liver and kidney problems can be exacerbated by L-arginine. Using L-arginine can also lead to problems of potassium balance and dehydration, as well as stomach cramps, nausea and other digestive discomfort [source: MedlinePlus]. Keep Reading Below There can also be some circulatory side effects associated with L-arginine.