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Because bioidentical hormones are an exact structural replica of endogenous hormones, side effects are rarely observed, and in the event you do experience side effects, talk with your doctorâthe dosage may simply need to be adjusted.
Both higher levels of exogenous and endogenous hormone exposure are associated with breast cancer risk. Because of the association between breast cancer and HRT, only the minimal duration of HRT use is recommended for symptom control, and it is not recommended for chronic disease management. For example, in the EHBCCG analysis of nine prospective studies of endogenous hormone levels and breast cancer risk, levels of multiple sex steroids â including total estradiol, free estradiol, estrone, and estrone sulfate â were associated with increased breast cancer risk.