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Glucosamine is a naturally occurring substance found in the fluid around our joints. It is naturally present in animal bones, bone marrow, shellfish and fungi. Glucosamine plays a vital role in building cartilage and is commonly consumed as a supplement by people with arthritis, especially osteoarthritis. Glucosamine, especially glucosamine sulfate, is harvested from the shells of shellfish and put into dietary supplements. It can also be made in the laboratory.
Glucosamine is a compound that is naturally made in humans. It is involved in the creation of molecules that form cartilage. Evidence supports the use of glucosamine sulfate in the treatment of knee osteoarthritis. It is believed that the sulfate portion may help strengthen cartilage. If this is confirmed, it would mean that the glucosamine sulfate form is more effective than glucosamine without sulfate.