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Graves' disease, also known as toxic diffuse goiter and Flajani-Basedow-Graves disease, is an autoimmune disease that affects the thyroid.It frequently results in hyperthyroidism and an enlarged thyroid.hyroid-associated ophthalmopathy is one of the most typical symptoms of Graves' disease. It is known by a variety of terms, the most common being Graves' ophthalmopathy. Thyroid eye disease is an inflammatory condition, which affects the orbital contents including the extraocular muscles and orbital fat.
1 Gravesâ disease is a type of autoimmunity in which the thyroid gland becomes overly active. 2  People who have Graves' disease may have trouble sleeping, irritability, unexplained weight loss, eyes that bulge, sensitivity to heat, muscle weakness, brittle hair, light menstrual periods, and hand shakiness. Rheumatoid arthritis is a type of arthritis in which autoimmunity causes the immune system to attack tissues in the joints, leading to muscle pain, joint deformities, fatigue, weakness, appetite loss, weight loss, and sometimes confinement to bed.