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Researchers do know from twin studies that genetics plays a role in personality disorders. Environmental factors, such as childhood abuse, neglect and separation from caregivers, as well as brain abnormalities, emotion regulation, impulsivity, aggression and serotonin levels all play a role.ecause many personality domains are heritable, borderline personality disorder may be a result of a genotype interacting with adverse environmental factors. This would in turn lead to the expression of borderline symptoms or other dysfunctional personality traits.
We found that the RAD17 gene is also essential for the function of the RAD9 checkpoint because it is required for phase-specific arrest of the same four cdc mutants. We also show that both X-or UV-irradiated cells require the RAD9 and RAD17 genes for delay in the G(2) phase.