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terminator codon mutations and hypofunctional genes responsible for various Î±-thalassemia syndromes [6]. Î±-thalassemia can be suspected based on factors such as a family history of anemia and ethnic and geographic backgrounds, particularly if the patients
Sickle cell anemia, a common form of sickle cell disease, is caused by a particular mutation in the HBB gene. This mutation results in the production of an abnormal version of beta-globin called hemoglobin S or HbS.In this condition, hemoglobin S replaces both beta-globin subunits in hemoglobin.eta thalassemia-caused by mutations in the HBB gene. Nearly 400 mutations in the HBB gene have been found to cause beta thalassemia. Most of the mutations involve a change in a single DNA building block (nucleotide) within or near the HBB gene.