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terminator codon mutations and hypofunctional genes responsible for various Î±-thalassemia syndromes [6]. Î±-thalassemia can be suspected based on factors such as a family history of anemia and ethnic and geographic backgrounds, particularly if the patients
There are two main types of thalassemia: 1  Alpha thalassemia occurs when a gene or genes related to the alpha globin protein are missing or changed (mutated). 2  Beta thalassemia occurs when similar gene defects affect production of the beta globin protein.