Social Determinants of Health. The complex, integrated, and overlapping social structures and economic systems that are responsible for most health inequities. These social structures and economic systems include the social environment, physical environment, health services, and structural and societal factors. Social determinants of health are shaped by the distribution of money, power, and resources throughout local communities, nations, and the world [9]. Socioeconomic Gradient in Health This term refers to the stepwise fashion health outcomes improve as socioeconomic position improves.
Causes. Maple syrup urine disease (MSUD) is caused by a gene defect. Persons with this condition cannot break down the amino acids leucine, isoleucine, and valine.
1 Intermittent maple syrup urine disease is a milder form of the disease. 2  Individuals with this type have a greater level of enzyme activity (approximately 8 to 15% of normal) and often do not have symptoms until 12 to 24 months of age, usually as a result of an illness or surge in protein intake. Classic maple syrup urine disease is the most common type. 2  Individuals with classic maple syrup urine disease have little or no enzyme activity (usually less than 2 % of normal). 3  Infants with this type of maple syrup urine disease will show symptoms within the first several days of life.