Programs that ignore the influence of community and family in the lives of young people are, in fact, creating a nearly impossible situationâasking young people to change their world on their own. It is unfair to ask youth to change their beliefs and behaviors without also providing community support for these changes.
The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is named this because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. property of the NMDA receptor is its voltage-dependent activation, a result of ion channel block by extracellular Mg 2+ & Zn 2+ ions. This allows the flow of Na + and small amounts of Ca 2+ ions into the cell and K + out of the cell to be voltage-dependent.
A ligand binds its receptor through a number of specific weak non-covalent bonds by fitting into a specific binding site or pocket. In situations where even low concentrations of a ligand will result in binding of most of the cognate receptors, the receptor affinity is considered to be high.Low receptor affinity occurs when a high concentration of the ligand is required for most receptors to be occupied.The dissociation constant (Kd,) is the concentration of ligand required to occupy one half of the total available receptors. This measurement of receptor affinity is often in the range of 10-4 to 10-9 mM.With prolonged exposure to a ligand (and occupation of the receptor) cells often become desensitized.he dissociation constant (Kd,) is the concentration of ligand required to occupy one half of the total available receptors. This measurement of receptor affinity is often in the range of 10-4 to 10-9 mM. With prolonged exposure to a ligand (and occupation of the receptor) cells often become desensitized.