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Layers of the Heart Wall. The wall of the heart consists of three layers: the epicardium (external layer), the myocardium (middle layer) and the endocardium (inner layer). The epicardium is the thin, transparent outer layer of the wall and is composed of delicate connective tissue.
Leave a comment Go to comments. Layers of the Heart Wall. The heart can be broken up into three major tissue layers: the endocardium, myocardium, and pericardium. Endocardium. The endocarium is the innermost, thin and smooth layer of epithelial tissue that lines the inner surface of all the heart chambers and valves.here are two layers of the pericardial sac: 1  Fibrous Pericardium: The fibrous pericardium is a strong layer which covers the heart. 2  It is made up mostly of connective tissue. 3  Its job is to protect the heart from overstretching and also anchor it in place.