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This supports the idea that in embryos from wild-type mothers, dpp H~- mutations cause the transformation of dorsal into ven-tral epidermis. If tissue determined to become dorsal epidermis dies in the dpp rim-null embryos, then one should not see ventral or lateral tissue formed in the double-mutant combination.
Wilm's tumour tumor suppressor gene1 (WT1) causes an embryonic malignancy of the kidney, affecting around 1 in 10,000 infants. It occurs in both sporadic and hereditary forms. Inactivation of WT1 causes Wilm's tumour, and Denys-Drash syndrome (DDS), leading to nephropathy and genital abnormalities. The WT1 protein has been found to bind a host of cellular factors, e.g. p53, a known tumor suppressor.