The most common cause of Angelman syndrome is a deletion of the maternal chromosome region 15q11-q13, which includes the UBE3A gene. Importantly, mutations and deletions of the UBE3A gene are sufficient to cause Angelman syndrome, making UBE3A the single gene responsible for the core symptoms of the disorder. Two major deletion classes known as class I and class II deletions in the 15q11-q13 region both cause Angelman syndrome.
1 ER+/PR+: About 65% of estrogen-receptor-positive breast cancers are also progesterone-receptor-positive. 2  This means that the cells have receptors for both hormones, which could be supporting the growth of the breast cancer.
When you get a breast cancer diagnosis, youâll be told what type of cancer you have. Your doctor gets a good idea of how the tumor may act and what kind of treatments may work best by knowing the type. You may be told your cancer is: Endocrine receptor-positive (estrogen or progesterone receptors) HER2-positive. Triple positive: positive for estrogen receptors, progesterone receptors, and HER2.