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Comparing carvedilol and metoprolol: results of the COMET trial. The Carvedilol or Metoprolol European Trial (COMET) compared overall mortality in patients with heart failure, randomised to receive either carvedilol or metoprolol tartrate.t is important to note that in the COMET trial, carvedilol was compared with metoprolol tartrate. The MERIT-HF trial compared metoprolol succinate to placebo and it was found that metoprolol succinate reduced the mortality rate by 34% in patients with heart failure.
The FDA has already stated that CR carvedilol can be given for the same mortality-reduction indication in systolic heart failure and post-MI LV systolic dysfunction that it had approved for the twice-daily version based on its pharmacokinetic and pharmacodynamic definitions of bioequivalence, Fonarow observed.