The program is an outgrowth of the 1986 National Childhood Vaccine Injury Act (NCVIA), which requires health care providers to report: Any event listed by the vaccine manufacturer as a contraindication to subsequent doses of the vaccine.
1 Men in the range of 60 to 69 years have normal PSA levels that are less than 4.5 ng/mL. 2  Men over the age of 70 years have normal PSA levels that are less than 6.5 ng/mL. 3  It is also important to note that the normal ranges of PSA results may vary from one laboratory to another.
Between these two groups is the diagnostic gray zone of the PSA value, 4.0 to 10.0 ng/mL, for which a positive biopsy of cancer is problematic. In this range, nearly 25% of men will have prostate cancer, and 75% will have benign prostatic enlargement.irst, age-specific reference ranges could improve the sensitivity of PSA by detecting curable, organ-confined tumors in younger men when the threshold of 4.0 ng/mL is lowered. Second, age-specific reference ranges could improve the specificity of the PSA test by raising the PSA threshold for normal among older men.