The only antidepressant with a half-life substantially in excess of 24 hours is fluoxetine. The parent drug has a half-life of 2 to 4 days and norfluoxetine, its active metabolite, has a half-life of 7 to 15 days. This half-life is even longer at doses above 20 mg/day in physically healthy older patients.
Toxic shock syndrome, or TSS, is a very rare and life-threatening bacterial infection. Some women can be affected by toxic shock syndrome from certain types of tampon, but men and children can also get TSS. Toxic shock syndrome can also be caused by boils, insect bites, scalds, burns or other wounds being infected by Staphylococcus aureus and Streptococcus pyogenes bacteria.
The exact cause of PMS is not known. Changes in brain hormone levels may play a role, but this has not been proven. Women with premenstrual syndrome may also respond differently to these hormones. PMS may be related to social, cultural, biological, and psychological factors. Up to 3 out of every 4 women experience PMS symptoms during their childbearing years. PMS occurs more often in women: