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The serotonin transporter gene (5-HTT) is considered as a candidate gene for BPD as multiple lines of evidence have suggested that it plays an important role in suicide, impulsive behaviour, and emotional liability.ompared with healthy controls, patients with BPD showed higher frequencies of the 10 repeat of the VNTR marker and the S-10 haplotype, and fewer 12 repeat and L A -12 haplotype. These results suggest that the serotonin transporter gene may play a role in the aetiology of BPD.
Feedback Regulation Loops. The endocrine system plays an important role in homeostasis because hormones regulate the activity of body cells. The release of hormones into the blood is controlled by a stimulus. For example, the stimulus either causes an increase or a decrease in the amount of hormone secreted.