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terminator codon mutations and hypofunctional genes responsible for various Î±-thalassemia syndromes [6]. Î±-thalassemia can be suspected based on factors such as a family history of anemia and ethnic and geographic backgrounds, particularly if the patients
Alpha thalassemia occurs when a mutation in the gene that codes for alpha globin results in reduced or absent production of alpha globins. Beta thalassemia occurs with a corresponding change in the beta globin gene. Therefore, the thalassemias are a result of quantitative mutations in the globin genes.