Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to Î¼-opioid receptors. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in Î¼-opioid binding.
Marilyn vos Savant. Marilyn vos Savant has a verified IQ of 190. In 1985, The Guinness Book of World Records accepted vos Savantâs IQ score of 190, and according to marilynvossavant.com, crowned her the woman with the highest IQ for five consecutive years â she has tested as high as 228 on various IQ tests.
Yao Defen. Yao Defen (1972) is the tallest living woman in the world and in the same, she is 3rd tallest woman ever after Zeng Jinlian, China, (8 feet 1 3/4 inch) who died in 1982 and Jane Bunford from UK , (7 feet 11 inches) who death in 1922). All these three women are Guinness book verified and the data is valid.