All cells require folic acid and it can diffuse easily into human cells. But the vitamin cannot enter bacterial cells and thus bacteria must make their own. The sulfa drugs such as sulfonamides inhibit a critical enzyme--dihydropteroate synthase--in this process. Once the process is stopped, the bacteria can no longer grow.
Sonoma Countyâs natural beauty and moderate temperatures seldom dip below freezing, even in the winter. The areaâs 25- to 30-inch annual rainfall happens primarily from November through April. January â Average high /low. Inland: 58 F (14 C) / 36 F (2 C) Coast: 56 F (13 C) / 35 F (2 C)
Sonoma CA. Explore Sonoma Countyâs history, with a trip to the town of Sonoma, home to Mission San Francisco Solano, the last Spanish-Mexican mission built in California. It also includes Buena Vista Winery, Californiaâs oldest winery, and Gundlach-Bundschu, the stateâs oldest, continually operating family winery.