Combination therapies with agents such as indoleamine 2,3-dioxygenase (IDO) inhibitors may have the potential to synergize with immunotherapeutic approaches to improve immune function against tumor cells.ombination therapies, such as with IDO inhibitors, have the potential to synergize with immunotherapeutic approaches.â Completion of the study is anticipated for November 2017. Alex A. Adjei, MD, PhD, FACP.
Cavities are caused by tooth decay â a process that occurs over time. Plaque forms. Your mouth naturally contains many types of bacteria. Some thrive on food and drinks that contain certain forms of sugar. When these sugars aren't cleaned off your teeth, the bacteria quickly begin feeding on them and producing acids.
Sensitivity to heat may also signify a small cavity, but it could be the result of an abscess, crack or severe decay. Chronic Toothache: If one or more of your teeth is affected by chronic toothache, nerve damage could be the cause.