When I was first diagnosed with thyroid cancer, I didn't feel any odd lumps or nodules in my neck, but I was suffering from muscle weakness, tiredness and getting constant colds. After a particularly nasty bug I noticed that my lymph nodes never seemed to go down in size.
SIRS is nonspecific and can be caused by ischemia, inflammation, trauma, infection, or several insults combined. Thus, SIRS is not always related to infection. Venn diagram showing overlap of infection, bacteremia, sepsis, systemic inflammatory response syndrome (SIRS), and multiorgan dysfunction.
They may cause a frameshift in the reading of the messenger RNA so that the amino acid sequence is incorrect and the protein product is prematurely terminated by encountering a stop codon. Mutations can be caused by defects in DNA replication. DNA repair systems, or they may be the result of environmental mutagens.