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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
No Evidence L-Arginine Lowers Blood Pressure in Humans. There is no evidence that arginine supplementation has any beneficial effects on blood pressure in humans. In fact, it is likely that taking arginine supplements wouldnât have any effect at all.