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Layers of the Heart Wall. The wall of the heart consists of three layers: the epicardium (external layer), the myocardium (middle layer) and the endocardium (inner layer). The epicardium is the thin, transparent outer layer of the wall and is composed of delicate connective tissue.
The atria and the ventricles are separated by valves, which allow the blood to flow through the heart in one direction and prevent back flow of blood. The wall of the heart is made up of three layers. The outer layer is called the epicardium. The middle layer is the actual heart muscle and is called the myocardium. The inner layer of the heart is called the endocardium. The heart is contained within a sac called the pericardium. The sole purpose of the heart is to pump blood to and from the rest of the body.