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Graves' disease, also known as toxic diffuse goiter and Flajani-Basedow-Graves disease, is an autoimmune disease that affects the thyroid.It frequently results in hyperthyroidism and an enlarged thyroid.hyroid-associated ophthalmopathy is one of the most typical symptoms of Graves' disease. It is known by a variety of terms, the most common being Graves' ophthalmopathy. Thyroid eye disease is an inflammatory condition, which affects the orbital contents including the extraocular muscles and orbital fat.
A systemic disease is one that affects a number of organs and tissues, or affects the body as a whole. AIDS â a disease caused by a virus that cripples the bodyâs immune defenses. 2  Grave's disease â a thyroid disorder, most often in women, which can cause a goiter (swelling in the front part of the neck) and protruding eyes.