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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
Answers. Best Answer: Based on ~5 years of reading arginine research papers, anything less than 5,000 milligrams (5 grams) per dose will not have a therapeutic effect. If you have high cholesterol, ~7 grams seems to be where the beneficial effect starts. Depending on how your body reacts, 5 grams is a good start (up to 20 grams may needed to receive health boosting if your body is arginine (resistant). Source(s): Linda R Â· 5 years ago.