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terminator codon mutations and hypofunctional genes responsible for various Î±-thalassemia syndromes [6]. Î±-thalassemia can be suspected based on factors such as a family history of anemia and ethnic and geographic backgrounds, particularly if the patients
How these genes are altered determines the specific type of beta thalassemia in a child: 1  Beta thalassemia major (Cooley's anemia). Both (two) beta chain genes have deletions, causing the most severe type of beta thalassemia. 2  Thalassemia minor or thalassemia trait. One beta gene has a deletion, resulting in anemia.