All cells require folic acid and it can diffuse easily into human cells. But the vitamin cannot enter bacterial cells and thus bacteria must make their own. The sulfa drugs such as sulfonamides inhibit a critical enzyme--dihydropteroate synthase--in this process. Once the process is stopped, the bacteria can no longer grow.
Sonoma Countyâs natural beauty and moderate temperatures seldom dip below freezing, even in the winter. The areaâs 25- to 30-inch annual rainfall happens primarily from November through April. January â Average high /low. Inland: 58 F (14 C) / 36 F (2 C) Coast: 56 F (13 C) / 35 F (2 C)
On average, there are 262 sunny days per year in Sonoma, California. The July high is around 83 degrees. The January low is 38. Sperling's comfort index for Sonoma is a 82 out of 100, where a higher score indicates a more comfortable year-around climate. The US average for the comfort index is 54.