All Valves Closed. This phase of the cardiac cycle begins with the appearance of the QRS complex of the ECG, which represents ventricular depolarization. This triggers excitation-contraction coupling, myocyte contraction and a rapid increase in intraventricular pressure. Early in this phase, the rate of pressure development becomes maximal.
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Melasma is a common skin condition in which brown patches appear on the skin. Melasma often affects the skin on the face. The patches tend to appear on the cheeks, forehead, nose or upper lip. Melasma can also develop on the forearms and neck. No, but it can severely affect your appearance and the way you feel about it.