The program is an outgrowth of the 1986 National Childhood Vaccine Injury Act (NCVIA), which requires health care providers to report: Any event listed by the vaccine manufacturer as a contraindication to subsequent doses of the vaccine.
1 Men in the range of 60 to 69 years have normal PSA levels that are less than 4.5 ng/mL. 2  Men over the age of 70 years have normal PSA levels that are less than 6.5 ng/mL. 3  It is also important to note that the normal ranges of PSA results may vary from one laboratory to another.
In order to increase the efficacy of serum PSA interpretation, a number of performance variables are used clinically. These include age-adjusted PSA, density, velocity, and the free-to-complexed PSA ratio. Age Adjusted PSA: Since PSA normally rises with age, age-adjusted thresholds have been described. Benign growth of the prostate that normally occurs with age is the most common cause of PSA elevation. Roughly 70% of patients with an elevated PSA level between 4 and 10 will have a negative prostate biopsy. Conversely, there is no level of PSA at which you can guarantee a patient that they do not have cancer. Moreover, the absolute PSA level does not predict whether or not prostate cancer is harmful.