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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
Responses (6) Zoloft and most SSRI / SNRI's take roughly one to two weeks to take effect. Some people experience a positive effect sooner, and some don't respond to the medication, and possibly the dosage needs to be increased, and or a different medication needs to be given a try. Votes: +1.