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When our skin suffers the affects of dehydration, skin problems occur. If you have chronic fatigue syndrome and skin problems, you may be suffering from dehydration. Pain and Joint Swelling. The pain and joint swelling that is so often associated with chronic fatigue syndrome can also be the result of joint dehydration.
Dehydration can lead to serious complications, including (from the Mayo Clinic): 1  Swelling of the brain (cerebral edema). Sometimes, when you're getting fluids after being dehydrated, the body tries to pull too much water back into your cells. This can cause some cells to swell and rupture.