Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to Î¼-opioid receptors. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in Î¼-opioid binding.
Marilyn vos Savant. Marilyn vos Savant has a verified IQ of 190. In 1985, The Guinness Book of World Records accepted vos Savantâs IQ score of 190, and according to marilynvossavant.com, crowned her the woman with the highest IQ for five consecutive years â she has tested as high as 228 on various IQ tests.
Meet Zlata The Most Flexible Woman On Earth. We've all seen contortionists on the TV. The degree of flexibility that these people have is incredible. The video below is of Zlata, a Kazakhstan-based contortionist, who blows all others out of the water! Unbelievably, Zlata has the same stretchy ligaments as a baby, whereas most other adults typically have a hardening of the ligaments as they get older. So that's her secret! You won't believe the shapes this woman can get into! Check it out!