Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to Î¼-opioid receptors. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in Î¼-opioid binding.
Marilyn vos Savant. Marilyn vos Savant has a verified IQ of 190. In 1985, The Guinness Book of World Records accepted vos Savantâs IQ score of 190, and according to marilynvossavant.com, crowned her the woman with the highest IQ for five consecutive years â she has tested as high as 228 on various IQ tests.
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