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This supports the idea that in embryos from wild-type mothers, dpp H~- mutations cause the transformation of dorsal into ven-tral epidermis. If tissue determined to become dorsal epidermis dies in the dpp rim-null embryos, then one should not see ventral or lateral tissue formed in the double-mutant combination.
Dihydropyrimidine dehydrogenase (DPD), an enzyme encoded by the DPYD gene, is the rate-limiting step in pyrimidine catabolism and deactivates more than 80% of standard doses of 5FU and the oral 5FU prodrug capecitabine. True deficiency of DPD affects approximately 5% of the overall population.