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In children and adolescents, risperidone may be more effective than lithium or divalproex, but has more metabolic side effects. As maintenance therapy, risperidone is effective for the prevention of manic episodes but not depressive episodes.
SIMPLICITY. The starting dosage of risperidone is 0.25 mg per day in children weighing less than 44 lb (20 kg), and 0.5 mg per day in persons weighing at least 44 lb. 8 Depending on weight, doses may be titrated by 0.25 to 0.5 mg per day at two-week intervals, with targets of 0.5 and 1.0 mg per day.009 Jun 15;79(12):1104-1107. Risperidone (Risperdal) is a mixed serotonin-dopamine antagonist labeled to treat schizophrenia and mania associated with bipolar I disorder in adults. It was recently approved for the treatment of irritability associated with autistic disorder in children five to 17 years of age.