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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
Side effects of L-arginine For certain groups of people there may be some risks involved in taking L-arginine as a supplement. L-arginine has some potential side effects to be aware of when taking it as a supplement. Some of the more common and benign side effects include: gout; bloating; abdominal pain; airway inflammation; diarrhea; low blood pressure; blood abnormalities; allergies; worsening of asthma; However, L-arginine may result in some serious complications that must be considered.