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Botox is remarkably safe, especially considering it's a powerful toxin. Occasionally, a mild headache that lasts a few hours may occur after an injection in muscles of the forehead. Very rarely, though, that headache may become excruciating and can last as long as a month.
Botulinum toxin (BotoxÂ®) Botox is a treatment option for adults with chronic migraine. Introduction. BotoxÂ® (onabotulinum toxin A) was licensed specifically for the treatment of chronic migraine in July 2010 by the Medicines and Healthcare products Regulatory Agency (MHRA). BotoxÂ® has not been shown to be effective for any other headache type (e.g. episodic migraine, tension-type headache, cluster headache) as yet.