All cells require folic acid and it can diffuse easily into human cells. But the vitamin cannot enter bacterial cells and thus bacteria must make their own. The sulfa drugs such as sulfonamides inhibit a critical enzyme--dihydropteroate synthase--in this process. Once the process is stopped, the bacteria can no longer grow.
Sonoma Countyâs natural beauty and moderate temperatures seldom dip below freezing, even in the winter. The areaâs 25- to 30-inch annual rainfall happens primarily from November through April. January â Average high /low. Inland: 58 F (14 C) / 36 F (2 C) Coast: 56 F (13 C) / 35 F (2 C)
Average temperature in California in March: 10.5Â°C, 51Â°F. Sea temperature in California (Los Angeles) in March: 16Â°C, 60Â°F. Average rainfall in California in March: 90.4mm, 3.5in. Note: The wet winter lingers on in California in March, although temperatures begin to rise slightly in anticipation of spring.