Whether you're a longtime subscriber, using a trial subscription, or just have questions about our service, we're here to help.
Researchers do know from twin studies that genetics plays a role in personality disorders. Environmental factors, such as childhood abuse, neglect and separation from caregivers, as well as brain abnormalities, emotion regulation, impulsivity, aggression and serotonin levels all play a role.ecause many personality domains are heritable, borderline personality disorder may be a result of a genotype interacting with adverse environmental factors. This would in turn lead to the expression of borderline symptoms or other dysfunctional personality traits.
EGFR promoter methylation was decreased and gene and protein expression was increased by IL-6. Thus, epigenetic regulation of gene expression by IL-6 can contribute to tumor progression by altering promoter methylation and gene expression of growth-regulatory pathways, such as those involving EGFR.