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Layers of the Heart Wall. The wall of the heart consists of three layers: the epicardium (external layer), the myocardium (middle layer) and the endocardium (inner layer). The epicardium is the thin, transparent outer layer of the wall and is composed of delicate connective tissue.
Your heart is one of the most important muscles in your body. Each day, your heart beats about 100,000 times and, over your life span, about 2.5 billion times! The fibrous pericardium encases, protects and secures the heart. Inside the pericardium is the heart wall, and this is organized into three main layers. The outermost layer of the heart wall is the epicardium, which is also the innermost layer of the pericardium. The middle layer of the heart wall is the myocardium; this is the actual muscular layer of the heart responsible for contracting and pumping blood throughout your body.