All cells require folic acid and it can diffuse easily into human cells. But the vitamin cannot enter bacterial cells and thus bacteria must make their own. The sulfa drugs such as sulfonamides inhibit a critical enzyme--dihydropteroate synthase--in this process. Once the process is stopped, the bacteria can no longer grow.
Sonoma Countyâs natural beauty and moderate temperatures seldom dip below freezing, even in the winter. The areaâs 25- to 30-inch annual rainfall happens primarily from November through April. January â Average high /low. Inland: 58 F (14 C) / 36 F (2 C) Coast: 56 F (13 C) / 35 F (2 C)
Sonoma Creek flows down the valley to the bay. The area includes the incorporated city of Sonoma and part of the City of Santa Rosa, as well as numerous unincorporated communities, including Kenwood and Glen Ellen near Santa Rosa and, near Sonoma, El Verano, Boyes Hot Springs, Fetters Hot Springs, and Agua Caliente.