All cells require folic acid and it can diffuse easily into human cells. But the vitamin cannot enter bacterial cells and thus bacteria must make their own. The sulfa drugs such as sulfonamides inhibit a critical enzyme--dihydropteroate synthase--in this process. Once the process is stopped, the bacteria can no longer grow.
Sonoma Countyâs natural beauty and moderate temperatures seldom dip below freezing, even in the winter. The areaâs 25- to 30-inch annual rainfall happens primarily from November through April. January â Average high /low. Inland: 58 F (14 C) / 36 F (2 C) Coast: 56 F (13 C) / 35 F (2 C)
Sonoma, California. Sonoma is a city in Sonoma Valley, Sonoma County, California, United States, surrounding its historic town plaza, a remnant of the town's Mexican colonial past. Today, Sonoma is a center of the state's wine industry for the Sonoma Valley AVA Appellation, as well as the home of the Sonoma International Film Festival. Sonoma's population was 10,648 as of the 2010 census, while the Sonoma urban area had a population of 32,678.