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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
Side effects. Most people taking arginine have few side effects. It can cause nausea, cramps, diarrhea, allergic reactions, and asthma symptoms. It could also cause low blood pressure and changes to glucose and blood chemical levels.