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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
Other Side Effects L-arginine supplementation can lead to several potentially serious side effects in addition to an allergic reaction. In some users, arginine supplementation may cause stomach discomfort, including nausea, stomach cramps, or increased bowel movements.