Social Determinants of Health. The complex, integrated, and overlapping social structures and economic systems that are responsible for most health inequities. These social structures and economic systems include the social environment, physical environment, health services, and structural and societal factors. Social determinants of health are shaped by the distribution of money, power, and resources throughout local communities, nations, and the world [9]. Socioeconomic Gradient in Health This term refers to the stepwise fashion health outcomes improve as socioeconomic position improves.
Causes. Maple syrup urine disease (MSUD) is caused by a gene defect. Persons with this condition cannot break down the amino acids leucine, isoleucine, and valine.
If left untreated, MSUD results in severe brain damage, coma, and death in infancy. MSUD can be effectively managed with dietary restriction of proteins. Approximately 1 in 125 Ashkenazi Jews is a carrier of Maple syrup urine disease.Screening for three gene mutations will detect more than 95% of carriers.f left untreated, MSUD results in severe brain damage, coma, and death in infancy. MSUD can be effectively managed with dietary restriction of proteins. Approximately 1 in 125 Ashkenazi Jews is a carrier of Maple syrup urine disease.