The only antidepressant with a half-life substantially in excess of 24 hours is fluoxetine. The parent drug has a half-life of 2 to 4 days and norfluoxetine, its active metabolite, has a half-life of 7 to 15 days. This half-life is even longer at doses above 20 mg/day in physically healthy older patients.
Toxic shock syndrome, or TSS, is a very rare and life-threatening bacterial infection. Some women can be affected by toxic shock syndrome from certain types of tampon, but men and children can also get TSS. Toxic shock syndrome can also be caused by boils, insect bites, scalds, burns or other wounds being infected by Staphylococcus aureus and Streptococcus pyogenes bacteria.
Stiff-person syndrome (SPS) is a rare neurological disorder with features of an autoimmune disease.SPS is characterized by fluctuating muscle rigidity in the trunk and limbs and a heightened sensitivity to stimuli such as noise, touch, and emotional distress, which can set off muscle spasms.Abnormal postures, often hunched over and stiffened, are characteristic of the disorder.t is frequently associated with other autoimmune diseases such as diabetes, thyroiditis, vitiligo, and pernicious anemia. Scientists donât yet understand what causes SPS, but research indicates that it is the result of an autoimmune response gone awry in the brain and spinal cord.