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Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
For coronary artery disease (CAD), up to nine grams of arginine has been taken by mouth daily in divided doses for three days to six months. 15 grams of L-arginine has been taken by mouth daily in addition to Cardiketâ¢ (isosorbide dinitrate) for 10 days. A dose of 3.2 grams has been taken by mouth twice daily for six months. Three grams of L-arginine has been taken by mouth three times daily for the first three days, followed by nine grams on day four.