When I was first diagnosed with thyroid cancer, I didn't feel any odd lumps or nodules in my neck, but I was suffering from muscle weakness, tiredness and getting constant colds. After a particularly nasty bug I noticed that my lymph nodes never seemed to go down in size.
SIRS is nonspecific and can be caused by ischemia, inflammation, trauma, infection, or several insults combined. Thus, SIRS is not always related to infection. Venn diagram showing overlap of infection, bacteremia, sepsis, systemic inflammatory response syndrome (SIRS), and multiorgan dysfunction.
The most common cause of Cushings syndrome is a pituitary tumor (Cushings disease). Other causes of Cushings syndrome include adrenal tumors or cancers and tumors in other parts of the body, such as the lung, thymus or pancreas making the hormone ACTH (ectopic ACTH syndrome). It is important to determine that the patient has Cushings syndrome before the type of Cushings syndrome is investigated.