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Layers of the Heart Wall. The wall of the heart consists of three layers: the epicardium (external layer), the myocardium (middle layer) and the endocardium (inner layer). The epicardium is the thin, transparent outer layer of the wall and is composed of delicate connective tissue.
The muscular walls of the heart consist of three major layers. The bulk of the walls is made up of a layer of cardiac muscle and is called the myocardium. The muscle is enclosed on the outside by the epicardium and on the inside by the endocardium. The heart is also covered completely by a protective sac called the pericardium.