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Botox is remarkably safe, especially considering it's a powerful toxin. Occasionally, a mild headache that lasts a few hours may occur after an injection in muscles of the forehead. Very rarely, though, that headache may become excruciating and can last as long as a month.
The Side Effects Of Botox. The side effects of Botox can include pain, swelling, and bruising at the site of the injection, dry mouth, headache, and fatigue. Botox can also cause more serious side effects. If the botulinum toxin spreads out beyond the site that's being treated, it can cause a life-threatening situation.