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Botox is remarkably safe, especially considering it's a powerful toxin. Occasionally, a mild headache that lasts a few hours may occur after an injection in muscles of the forehead. Very rarely, though, that headache may become excruciating and can last as long as a month.
As far as spasms, you can occasionally have a patient get twitching of a muscle as it begins to work again after the Botox wears off. This is very mild and only lasts a very short period of time or it will go away once the muscle is injected again. Botox does not travel once to far off places but it can diffuse. around the area of injection. Botox can not cause numbness as it only. works on the nerve to muscle communication and does not work on pain. receptors.