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Quick Answer. Endometrial hyperplasia is an abnormal thickening of the lining of the uterus, according to the American Congress of Obstetricians and Gynecologists. The condition usually develops during menopause and perimenopause when ovulation is irregular or absent. It can also occur in women affected by polycystic ovary syndrome or obesity.
These changes are similar to those seen in true cancer cells, although with atypical hyperplasia it shows no signs of invading connective tissues. Risk of Progression to Endometrial Cancer: 8 to 10 percent. Type: Complex with Atypical Description: As above, but also with worrying pre-cancerous cell changes.