The most common cause of Angelman syndrome is a deletion of the maternal chromosome region 15q11-q13, which includes the UBE3A gene. Importantly, mutations and deletions of the UBE3A gene are sufficient to cause Angelman syndrome, making UBE3A the single gene responsible for the core symptoms of the disorder. Two major deletion classes known as class I and class II deletions in the 15q11-q13 region both cause Angelman syndrome.
1 ER+/PR+: About 65% of estrogen-receptor-positive breast cancers are also progesterone-receptor-positive. 2  This means that the cells have receptors for both hormones, which could be supporting the growth of the breast cancer.
To determine whether breast cancer cells contain hormone receptors, doctors test samples of tumor tissue that have been removed by surgery. If the tumor cells contain estrogen receptors, the cancer is called estrogen receptor-positive (ER-positive), estrogen-sensitive, or estrogen-responsive.umors that are hormone-insensitive do not respond to hormone therapy. Hormone therapy for breast cancer is not the same as menopausal hormone therapy or female hormone replacement therapy, in which hormones are given to reduce the symptoms of menopause.