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A lack of appetite is usually one of the earliest signs that your dog might be pregnant. Not all females go through this doggie version of morning sickness, but a small percentage of dogs will eat less during the first few weeks of gestation and will usually make up for it later in the pregnancy.
See Your Vet. If you think your dog is pregnant, take her to your vet. It's a good idea to take her for a prenatal checkup 2 or 3 weeks after she has mated. Your vet can answer any questions you may have, such as the type of food pregnant dogs should eat and what changes you should expect.