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A Barr body is the inactivated X chromosome that is usually found in the nuclei of female somatic cells. It can also occur in males when there is an abnormality and the male is XXY instead of the normal XY, a condition known as Klinefelter's syndrome.
The inactivated X is visible during interphase in mitosis as a condensed chromosome, called a Barr body. It replicates in the S (synthesis) phase of the cell cycle later than does the active copy. Inactivation of one of the two X copies in a female leaves only one active X chromosome in any cell. An individual who has three X chromosomes has two inactivated copies of the X, producing two Barr bodies. Because the X is inactivated randomly in cells, one cell could have the maternal X inactivated, while the adjacent cell could have the paternal X inactivated.