Tofranil (imipramine): 1  Is generally used in children older than 6 years. 2  Has a success rate of 10 to 50 percent. 3  Starts working in a few days. 4  Is relatively inexpensive. 5  Will likely stop working when the child stops taking the medication.
The plateau pressure is the pressure applied (in positive pressure ventilation) to the small airways and alveoli. It is believed that control of the plateau pressure is important, as excessive stretch of alveoli has been implicated as the cause of ventilator induced lung injury.
believe the answer you're looking for has to do with the pressure-altitude-voltage derating related to corona discharge, which increases (gets worse) with higher altitude and peaks at around 80-100,000' Typically this is considered to occur at votlages above 300 V peak, but be sure you are accounting for all transients and internal voltages.