What is DUEXIS Â® (ibuprofen and famotidine)? DUEXIS contains two medicines: ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), and famotidine, a histamine H 2-receptor antagonist.
Various factors contribute to foot and ankle swelling during pregnancy. For starters, your body retains more fluid during pregnancy. Also, your growing uterus puts pressure on your veins, which impairs return of blood to your heart. This can lead to swelling in the legs, ankles and feet.
Sometimes diseases that affect the entire body, such as heart disease and kidney or liver failure, can result in excess fluid buildup (edema) that is often concentrated in the legs and feet, leading to swelling not only of the ankles but also of the feet and lower legs. This can also occur with pregnancy.