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[4,5] The accelerated vaccination schedule for monovalent hepatitis B vaccine, administered on days 0, 7 and 21, rapidly induces long-lasting (>12 months) hepatitis B antibodies (anti-HBs) and high rates of seroprotection.
With the advent of combination vaccine, WHO has suggested an additional schedule with monovalent HepB vaccine at birth and DPT-HepB at 6, 10 and 14 weeks. This third option is to make the logistics simpler, which entails a higher cost of the fourth dose (Table II)(7).he principal objective of hepatitis B immunization and its sequelae is to prevent chronic HBV infection and its sequelae. Hepatitis B immunization strategies include a three-pronged attack: (i) routine infant vaccination; (ii) prevention of perinatal HBV transmission; (iii) catch-up vaccination of older age groups.