Antibiotics effective against procaryotes which kill or inhibit a wide range of Gram-positive and Gram-negative bacteria are said to be broad spectrum . If effective mainly against Gram-positive or Gram-negative bacteria, they are narrow spectrum.
Sofia: Annual Weather Averages. July is the hottest month in Sofia with an average temperature of 21Â°C (70Â°F) and the coldest is January at -1Â°C (30Â°F) with the most daily sunshine hours at 10 in July. The wettest month is April with an average of 70mm of rain. Average Temperature: Sofia. Loading weather data.
Find a cheap flight to Sofia and see a city with Turkish and Russian influences (Bulgaria was a contented Soviet state for 50 years) and a dash of European Union connectedness (since 2007), Sofia is a fascinating place to visit.At about 7,000 years old, it is one of the oldest cities in Europe.he shoulder seasons of spring and autumn can be a great time to visit as there are less tourists and it is more likely youâll find a cheap flight to Sofia and hotel. The climate is fairly mild, but may suit those who prefer to explore the city when it is a little cooler.