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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
Side Effects and Contraindications of Aspirin Therapy. If you are using aspirin for dogs, watch for blood in the dog's stool. This is a key sign that the dog is experiencing ulcers from the aspirin. Stop giving the dog aspirin and contact your vet.