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1 Anxiety: An initial dose of 0.25 mg to 0.5 mg of Xanax is administered orally, three times a day. 2  The dose can be increased gradually every three to four days up to maximum daily dose of 4 mg in divided doses.3  Panic: An initial dose of 0.5 mg of Xanax is administered orally, three times a day. Depression: An initial dose of 0.5 mg of Xanax is administered orally three times a day. 2  The dose can be increased by no more than 1 mg every three to four days. 3  An average dose of 3 mg of Xanax daily in divided doses has shown to be most effective.
Slower titration to the dose levels greater than 4 mg/day may be advisable to allow full expression of the pharmacodynamic effect of Xanax. To lessen the possibility of interdose symptoms, the times of administration should be distributed as evenly as possible throughout the waking hours, that is, on a three or four times per day schedule.