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Intrinsic factor. Intrinsic factor (IF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 (cobalamin) later on in the small intestine. In humans, the gastric intrinsic factor protein is encoded by the GIF gene.
Because intrinsic factor is crucial for the normal absorption of B 12, its lack in pernicious anemia causes a vitamin B12 deficiency. Many other subtler kinds of vitamin B 12 deficiency and their biochemical effects have since been elucidated.ecause intrinsic factor is crucial for the normal absorption of B 12, its lack in pernicious anemia causes a vitamin B12 deficiency. Many other subtler kinds of vitamin B 12 deficiency and their biochemical effects have since been elucidated.