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The most common and less serious side effects of metformin are bloating, gas, stomach pain, weakness, diarrhea, constipation, heartburn, sneezing, headaches, cough, flushing of the skin, vomiting, runny nose, nausea and muscle pain.
Metformin long term side effects. Common Questions and Answers about Metformin long term side effects. glucophage. Yes, one nasty side effect of Metformin is nausea. He should have been aware of this from reading the pharmaceutical paperwork that accompanied the Metformin bottle, or by his Pharmacist.