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Definition of span. 1  1 : the distance from the end of the thumb to the end of the little finger of a spread hand; also : an English unit of length equal to nine inches (22.9 centimeters)
The difference between span and div is that a span element is in-line and usually used for a small chunk of HTML inside a line (such as inside a paragraph) whereas a div (division) element is block-line (which is basically equivalent to having a line-break before and after it) and used to group larger chunks of code.