Tofranil (imipramine): 1  Is generally used in children older than 6 years. 2  Has a success rate of 10 to 50 percent. 3  Starts working in a few days. 4  Is relatively inexpensive. 5  Will likely stop working when the child stops taking the medication.
The peak pressure is the pressure measured by the ventilator in the major airways, and it strongly reflects airways resistance. For example, in acute severe asthma, there is a large gradient between the peak pressure (high) and the plateau pressure (normal). In pressure controlled ventilation, the pressure limit is (usually) the plateau pressure due to the dispersion of gas in inspiration.
PiP (the pressure outside the lungs) is not uniformly distributed. It is smaller at the base than the apex of the lung. A cause for this difference is the weight of the lung, which would result in a stronger pull from the chest wall at the apex.