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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
It can relieve pain effectively, and relatively safely, in your dog when used for SHORT PERIODS. There are two main dangers associated with using aspirin for dogs on a long-term basis: Aspirin is made from acetylsalicylic acid and when used for an extended length of time it can actually destroy cartilage and end up. making joint problems much worse.