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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
Aspirin can be administered, in small doses, for the temporary relief of dog arthritis pain. However, for long-term management and especially for more severe cases of dog arthritis, your vet may want to write a prescription.