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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
There are some health conditions which can interact with aspirin in a dangerous, even fatal, way. If your dog has any of these issues, please do not give him aspirin without consulting your veterinarian first. Regular 'people' aspirin formulas shouldn't be given to a dog for more than 5 days maximum.