Certain sub-stances in grapefruit juice block the action of CYP3A4, so instead of being metabolized, more of the drug enters the bloodstream and stays in the body longer. The result: potentially dangerous levels of the drug in your body. The amount of the CYP3A4 enzyme in the intestine varies from one per-son to another, says Huang. Some people have a lot, and others have just a littleâso grapefruit juice may affect people differently when they take the same drug.
3. Splitting Fruit. Like the foliage thatâs dying back, splitting tomato fruit is a sign of uneven watering. As the fruit is ripening if the plant receives too much water the skin will split because the fruitâs skin can no longer expand.
Thank you for reporting this comment. Why are my tomatoes dying from the bottom up? would it make you feel better if they were dying from the top down? The older leaves are on the bottom dying of old age. the leaves at the top are younger leaves that will die when their time comes. why do old people die before young children? same question same answer.