Certain sub-stances in grapefruit juice block the action of CYP3A4, so instead of being metabolized, more of the drug enters the bloodstream and stays in the body longer. The result: potentially dangerous levels of the drug in your body. The amount of the CYP3A4 enzyme in the intestine varies from one per-son to another, says Huang. Some people have a lot, and others have just a littleâso grapefruit juice may affect people differently when they take the same drug.
3. Splitting Fruit. Like the foliage thatâs dying back, splitting tomato fruit is a sign of uneven watering. As the fruit is ripening if the plant receives too much water the skin will split because the fruitâs skin can no longer expand.
What Causes Tomato Plants' Leaves to Start Dying From the Bottom? Growing tomatoes in the home garden can be a productive and rewarding endeavor. However, a gardener may become frustrated if their well-maintained tomato plant begins dying, starting with the bottom leaves and spreading upward. This type of death could be caused by a number of pathogens, most of them fungal.