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The most common and less serious side effects of metformin are bloating, gas, stomach pain, weakness, diarrhea, constipation, heartburn, sneezing, headaches, cough, flushing of the skin, vomiting, runny nose, nausea and muscle pain.
Metformin Side Effects. Side effects for metformin often become less severe and less common as the patient adjusts their dosage and continues taking the medication. The most common side effects include decreased appetite, fever, general discomfort, difficulty urinating, sleepiness, lower back pain or cough.