Certain sub-stances in grapefruit juice block the action of CYP3A4, so instead of being metabolized, more of the drug enters the bloodstream and stays in the body longer. The result: potentially dangerous levels of the drug in your body. The amount of the CYP3A4 enzyme in the intestine varies from one per-son to another, says Huang. Some people have a lot, and others have just a littleâso grapefruit juice may affect people differently when they take the same drug.
3. Splitting Fruit. Like the foliage thatâs dying back, splitting tomato fruit is a sign of uneven watering. As the fruit is ripening if the plant receives too much water the skin will split because the fruitâs skin can no longer expand.
Tomato blight, in its different forms, is a disease that attacks a plantâs foliage, stems, and even fruit. Early blight (one form of tomato blight) is caused by a fungus, Alternaria solani, which over-winters in the soil and infected plants. Affected plants underproduce. Leaves may drop, leaving fruit open to sunscald. Early blightâs Latin name is sometimes confused with a form of tomato rot, alternaria, a different tomato problem altogether.