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Intrinsic factor. Intrinsic factor (IF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 (cobalamin) later on in the small intestine. In humans, the gastric intrinsic factor protein is encoded by the GIF gene.
Intrinsic factor is produced in the fundus and body of the stomach by parietal cells that line the stomach.The purpose of intrinsic factor is so vitamin B can be absorbed in the small intestine.plit and merge into it. Answered by The Community. Making the world better, one answer at a time. Intrinsic factor is produced in the fundus and body of the stomach by parietal cells that line the stomach. The purpose of intrinsic factor is so vitamin B can be absorbed in the small intestine.