Inflammation and degradation of bone are two closely linked processes. Chronic inflammatory arthritis not only leads to inflammatory bone loss but it also involves local erosion of articular bone. This osteo-destructive feature of chronic inflammatory arthritis is a major cause of disability in patients with rheumatoid arthritis.
[ËÄ§alab]) is the largest city in Syria and serves as the capital of the Aleppo Governorate, the most populous Syrian governorate. With an official population of 2,132,100 (2004 census), it is also one of the largest cities in the Levant.
The loss of Aleppo is a major strategic defeat for the rebels. It was the most densely populated and prosperous region under their control, their most prized possession. They managed local services and their half of the city served as a sort of de facto capital. Their defeat is telling on a number of levels.