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The function of the immunological barrier in the epididymis is to protect the sperm from attack by the immune system. Primarily, this function is carried out by the BEB, which sequesters sperm antigens and restricts entry of immunoglobulins and immune cells (Fig. 2 B).
It can also help establish where two specimens of DNA match, thus allowing identification of the same DNA profile to be made for legal reasons. Whilst DNA is important biologically, it is also becoming an increasing factor in our everyday lives, with immigration processes, the police and the judicial system all relying on formal DNA testing as part of their fact-finding procedures.