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But when you stop using opiates abruptly, your body will react, leading to symptoms of withdrawal. Opiate withdrawal occurs in two phases. The first includes a number of symptoms, such as: 1  muscle aches. 2  restlessness. 3  anxiety. 4  tearing eyes. 5  runny nose. 6  excessive sweating.
Opiate Withdrawal Timeline. (DOES NOT INCLUDE METHADONE OR BUPRENORPHINE) Day 1 â 3 â These are the most difficult days to get through and also where most relapses tend to occur. The withdrawal symptoms usually kick in about 12 hours after the last dose was taken, or even before with lighter symptoms like agitation.