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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
You can cautiously provide aspirin to your pet dog but you should consult with a vet first. A natural alternative may be equally effective and much safer. While aspirin is generally an effective remedy for dogs suffering with pain, people confuse brands and variations of NSAID pain relievers which is very dangerous.