Inflammation and degradation of bone are two closely linked processes. Chronic inflammatory arthritis not only leads to inflammatory bone loss but it also involves local erosion of articular bone. This osteo-destructive feature of chronic inflammatory arthritis is a major cause of disability in patients with rheumatoid arthritis.
[ËÄ§alab]) is the largest city in Syria and serves as the capital of the Aleppo Governorate, the most populous Syrian governorate. With an official population of 2,132,100 (2004 census), it is also one of the largest cities in the Levant.
For centuries, Aleppo was the Syrian region 's largest city and the Ottoman Empire 's third-largest, after Constantinople and Cairo. Aleppo is one of the oldest continuously inhabited cities in the world; it has been inhabited since perhaps as early as the 6th millennium BC.