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The most common and less serious side effects of metformin are bloating, gas, stomach pain, weakness, diarrhea, constipation, heartburn, sneezing, headaches, cough, flushing of the skin, vomiting, runny nose, nausea and muscle pain.
Symptoms of lactic acidosis include weakness, sleepiness, slow heart beat, feeling cold, muscle pain, shortness of breath, loss of consciousness, etc. Although metformin does not directly cause kidney damage, the patients who have kidney damage and or kidney disease should not use the medicine. Another significant complication of metformin is Acute Kidney Failure. Gastrointestinal problems such as, significant diarrhea or vomiting commonly occur in people who are taking metformin therapy when there is underlying chronic kidney disease. It can lead to severe dehydration and acute renal failure.