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Elephantiasis (el-e-fan-TY-a-sis) is the result of a tropical worm infection called filariasis (fil-a-RY-a-sis). When infected mosquitoes transmit the parasitic worm Wuchereria bancrofti to people, the worm blocks the lymphatic system. The blockage causes swelling in the legs or other parts of the body, making these body parts appear large and puffy, or elephant-like. Elephantiasis is not elephant man disease, which is an inherited condition with completely different causes and symptoms.
The elephant's aggression may be partially caused by a reaction to the temporin, which naturally trickles down into the elephant's mouth. Another contributing factor may be the accompanying swelling of the temporal glands; this presses on the elephant's eyes and causes acute pain comparable to severe root abscess toothache.