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The function of the immunological barrier in the epididymis is to protect the sperm from attack by the immune system. Primarily, this function is carried out by the BEB, which sequesters sperm antigens and restricts entry of immunoglobulins and immune cells (Fig. 2 B).
The barrier function of the bloodâbrain barrier is due to: (1) tight junctions that restrict movement of substances between the endothelial cells, (2) specific transport proteins that determine which substances can cross the barrier transcellularly and (3) enzymes that may degrade or alter substances prior to passage.rain capillaries form a tight barrier except in specialised areas. Tight junctions restrict paracellular movement of substances across the bloodâbrain barrier. Astrocytes contribute to differentiation of the bloodâbrain barrier. Transport across the bloodâbrain barrier may be passive or active.