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The most common and less serious side effects of metformin are bloating, gas, stomach pain, weakness, diarrhea, constipation, heartburn, sneezing, headaches, cough, flushing of the skin, vomiting, runny nose, nausea and muscle pain.
Treatment with metformin can cause a serious condition called lactic acidosis (the accumulation of too much acid in the blood), which requires urgent hospital treatment. Its symptoms include muscle cramps, abdominal pain, breathlessness and a feeling of being very weak and unwell.