Muscle cramps on Imbruvica. I am currently on my 4th month of taking Imbruvica. I have recently noticed that I get muscle cramps a lot more frequently than I ever did before. Mostly in my feet and hands, but also in my legs, ribs and even my neck. If I move the wrong way I am going to cramp.
Squamous metaplasia refers to benign non-cancerous change (metaplasia) of (non-squamous) surfacing lining cells (epithelium) to a squamous morphology.n regards to the cervix, squamous metaplasia can sometimes be found in the endocervix, as it is composed of simple columnar epithelium, whereas the ectocervix is composed of stratified squamous non-keratinized epithelium.
Thus, there is metaplasia of normal respiratory laryngeal epithelium to squamous epithelium in response to chronic irritation of smoking. The two forms of cellular transformation that are potentially reversible, but may be steps toward a neoplasm, are:Metaplasia: the exchange of normal epithelium for another type of epithelium. Metaplasia is reversible when the stimulus for it is taken away.Dysplasia: a disordered growth and maturation of an epithelium, which is still reversible if the factors driving it are eliminated.he chronic irritation from cigarette smoke has led to an exchanging of one type of epithelium (the normal respiratory epithelium at the right) for another (the more resilient squamous epithelium at the left).