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1 Anxiety: An initial dose of 0.25 mg to 0.5 mg of Xanax is administered orally, three times a day. 2  The dose can be increased gradually every three to four days up to maximum daily dose of 4 mg in divided doses.3  Panic: An initial dose of 0.5 mg of Xanax is administered orally, three times a day. Depression: An initial dose of 0.5 mg of Xanax is administered orally three times a day. 2  The dose can be increased by no more than 1 mg every three to four days. 3  An average dose of 3 mg of Xanax daily in divided doses has shown to be most effective.
Larry, I have been on Xanax 0.25 mg three times a day for the last twenty years (20) for Panic Disorder. I had my initial Panic Attack while a student in Air Traffic Controller School. My max daily dosage is 1.5 mg-1.75 mg, and I can feel myself building up a tolerance to it.ypically in cases of treating generalized anxiety or social anxiety, a person only will need about 0.25 mg to 0.5 mg to alleviate symptoms. Even for panic attacks, the maximum recommended dose is only 0.5 mg.