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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
The chart below will help you find the recommended dosage of aspirin for your dog. The blue line is the minimum dosage (always start with this) and the red line shows the maximum dosage. For example, using the chart you can see that a 40lb dog should be given 200mg, and the maximum dose for the same dog would be 400mg.