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calcine calÂ·cine (kÄl-sÄ«n, kÄl'sÄ«n) v. calÂ·cined, calÂ·cining, calÂ·cines. To heat a substance to a high temperature but below the melting or fusing point, causing loss of moisture, reduction, or oxidation and the decomposition of carbonates and other compounds.
Colchicine is an alternative for those unable to tolerate NSAIDs in gout. At high doses, side effects (primarily gastrointestinal upset) limit its use. At lower doses, which are still effective, it is well tolerated.vailability of tubulin is essential to mitosis, so colchicine effectively functions as a mitotic poison or spindle poison. The mitosis-inhibiting function of colchicine has been of great use in the study of cellular genetics.