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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
Aspirin can cause gastrointestinal upsets and ulcers in dogs, just as in humans. You should pay attention to your dog's eating habits when administering aspirin to watch for signs of an upset stomach. If there are any signs of ulcers, such as blood-tinged vomiting, it is important to stop the aspirin.