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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
Human aspirin can be given to dogs, but should not be used for over a maximum of 5 days. Dog-aspirin also has a recommended duration of use; be sure to follow the instructions on the bottle of the brand your choose to use. It is a good option for immediate pain relief and swelling in dogs.