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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
A typical tablet contains 200 milligrams, so only a fraction of that pill is safe for most dogs. When your pet is in pain, it's common to want to administer a painkiller like Ibuprofen or aspirin. Dogs should not take human medications. Ask your vet about safe dog medicines. Despite the low cost, dogs rarely survive Ibuprofen overdose.