Owing to melatonin's antioxidant properties, the use of melatonin for the prevention of postoperative pericardial adhesion formation has been investigated. Twelve dogs received pericardial abrasions to promote adhesion and were randomized to receive either melatonin 10 mg/kg plus ethanol 5% in 10 mL sodium chloride or 10 mL sodium chloride dilution with ethanol 5%.
Definition of multifactorial. 1  1 : having characters or a mode of inheritance dependent on a number of genes at different loci. 2  2 or multifactorplay \-Ëfak-tÉr\ : having, involving, or produced by a variety of elements or causes.
Definition of COFACTOR. 1. : the signed minor of an element of a square matrix or of a determinant with the sign positive if the sum of the column number and row number of the element is even and with the sign negative if it is odd. 2.