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But when you stop using opiates abruptly, your body will react, leading to symptoms of withdrawal. Opiate withdrawal occurs in two phases. The first includes a number of symptoms, such as: 1  muscle aches. 2  restlessness. 3  anxiety. 4  tearing eyes. 5  runny nose. 6  excessive sweating.
Symptoms of opiate withdrawal usually begin within 12 hours of the last heroin use or within 30 hours of the last methodone use. Initial withdrawal symptoms peak after about three days and tend to last for five days.Flu-like symptoms generally subside after ten days. Many people try to quit heroin and opiate use alone.This is often a very dangerous and potentially fatal decision. The major symptoms* of acute withdrawal are: 1  Depression. 2  Insomnia. 3  Nausea. 4  Vomiting. 5  Diarrhea. 6  Abdominal cramps.any people try to quit heroin and opiate use alone. This is often a very dangerous and potentially fatal decision. The major symptoms* of acute withdrawal are: 1  Depression. 2  Insomnia. 3  Nausea. 4  Vomiting. 5  Diarrhea.