1 Distance between North Carolina, NC and cities in North Carolina. 2  Distance between North Dakota, ND and cities in North Dakota. 3  Distance between Ohio, OH and cities in Ohio.
HER2 is a proto-oncogene that encodes an 185 k Datrans membrane receptor tyrosine kinase which exhibits extensive homology to epidermal growth factor receptor (EGFR) .HER2 is also known as the neu and cerbB2 proto-oncogene.ER2 is a proto-oncogene that encodes an 185 k Datrans membrane receptor tyrosine kinase which exhibits extensive homology to epidermal growth factor receptor (EGFR) .
ity.18,19 The Abl SH2 domain forms an extensive interaction interface with the C-terminal lobe of the kinase domain that is stabilized by an interlocking network of hydrogen bonds (Fig. 2).18 Due to the different relative orientation of the 2 kinase lobes in Src and Abl, the SH2 domain approaches the kinase domain much closer in Abl (Fig. 2). The SH2âC-