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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
Like humans, dogs can experience pain from injuries, infections or disease. And when a dog is in pain whether it is due to traumatic or inflammatory reasons (such as canine arthritis), aspirin can be given as an effective medication to help your pet control the pain and relieve inflammation.