23 105442. The American Bulldog and Pit Bull are often confused as being the same breed due to their similar physical appearance and equal classification as working dogs in the Molosser family. However, a trained eye can easily distinguish that these two breeds are actually very different.
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Proof-of-Concept Clinical Trials. Signs of activity. Groundwork for definitive studies. Proof-of-concept clinical trials are carefully designed to establish the safety of drug candidates in the target population and explore the relationship between the dose and desired activity, as either measured directly or by means of a surrogate.