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But when you stop using opiates abruptly, your body will react, leading to symptoms of withdrawal. Opiate withdrawal occurs in two phases. The first includes a number of symptoms, such as: 1  muscle aches. 2  restlessness. 3  anxiety. 4  tearing eyes. 5  runny nose. 6  excessive sweating.
Prescription drug addiction alters the circuits responsible for mood and reward behaviors. In addition, long-term prescription drug abuse affects virtually all the systems in the body. Cutting off the supply abruptly leads to opioid withdrawal symptoms. Symptoms of opioid withdrawal include: 1  Craving for drugs. 2  Diarrhea. 3  Large pupils. 4  Yawning. 5  Abdominal pain. 6  Chills and goose bumps (the origin of the phrase cold turkey). 7  Nausea and vomiting. 8  Body aches.