Tofranil (imipramine): 1  Is generally used in children older than 6 years. 2  Has a success rate of 10 to 50 percent. 3  Starts working in a few days. 4  Is relatively inexpensive. 5  Will likely stop working when the child stops taking the medication.
The plateau pressure is the pressure applied (in positive pressure ventilation) to the small airways and alveoli. It is believed that control of the plateau pressure is important, as excessive stretch of alveoli has been implicated as the cause of ventilator induced lung injury.
Plateau pressures are determined by an inspiratory hold maneuver in which the patient is given a fixed volume of air. The PIP is determined at the end of that inspiration. The drop-off that occurs between the PIP and plateau pressure is airway resistance which was overcome during the inspiratory phase.