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Homozygous and Heterozygous. If an organism has two copies of the same allele, for example AA or aa, it is homozygous for that trait. If the organism has one copy of two different alleles, for example Aa, it is heterozygous. Keep in mind that an organism can't simply be 'homozygous,' period. For each of the organism's thousands of genes, it is either homozygous or heterozygous at that genetic locus.
From Wikipedia, the free encyclopedia. A heterozygote advantage (heterozygous advantage) describes the case in which the heterozygote genotype has a higher relative fitness than either the homozygote dominant or homozygote recessive genotype. common example is the case where the heterozygote conveys both advantages and disadvantages, while both homozygotes convey a disadvantage. A well-established case of heterozygote advantage is that of the gene involved in sickle cell anaemia.