1 Distance between North Carolina, NC and cities in North Carolina. 2  Distance between North Dakota, ND and cities in North Dakota. 3  Distance between Ohio, OH and cities in Ohio.
HER2 is a proto-oncogene that encodes an 185 k Datrans membrane receptor tyrosine kinase which exhibits extensive homology to epidermal growth factor receptor (EGFR) .HER2 is also known as the neu and cerbB2 proto-oncogene.ER2 is a proto-oncogene that encodes an 185 k Datrans membrane receptor tyrosine kinase which exhibits extensive homology to epidermal growth factor receptor (EGFR) .
Receptor tyrosine kinases (RTKs), which bind to peptide / protein hormones, may exist as dimers or dimerize during binding to ligands. Ligand binding leads to activation of the kinase activity of the receptor and autophosphorylation of tyrosine residues in its cytosolic domain (see Figure 20-31).The activated receptor also can phosphorylate other protein substrates.igand binding leads to activation of the kinase activity of the receptor and autophosphorylation of tyrosine residues in its cytosolic domain (see Figure 20-31). The activated receptor also can phosphorylate other protein substrates.