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The function of the immunological barrier in the epididymis is to protect the sperm from attack by the immune system. Primarily, this function is carried out by the BEB, which sequesters sperm antigens and restricts entry of immunoglobulins and immune cells (Fig. 2 B).
In this Minireview, we clarify that the barriers in both the testis and epididymis are more complex and are not comprised only of epithelial cell tight junctions (the physical or anatomical barrier), but also include physiological and immunological barriers.n this Minireview, we clarify that the barriers in both the testis and epididymis are more complex and are not comprised only of epithelial cell tight junctions (the physical or anatomical barrier), but also include physiological and immunological barriers.