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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
Aspirin For Dogs. Aspirin is a popular painkiller and anti-clotting agent used widely around the world. It is an NSAID derived from salicin, a naturally occuring substance which can be found in many plants and trees.