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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
Adverse reactions to aspirin are relatively common in dogs, which means you need to be aware of the risks and the symptoms of an adverse reaction or overdose before giving your dog the drug. If you notice any of the following symptoms, stop giving your dog aspirin immediately and call your vet. 1  Vomiting. 2  Diarrhea. 3  Mucosal erosion. 4  Ulceration. Black, tarry stool.