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The most common and less serious side effects of metformin are bloating, gas, stomach pain, weakness, diarrhea, constipation, heartburn, sneezing, headaches, cough, flushing of the skin, vomiting, runny nose, nausea and muscle pain.
Other possible side effects of metformin include headache, nausea, vomiting, change in taste and loss of appetite, muscle pain and flushing or increased sweating. It's also possible to have an allergic reaction to metformin. Symptoms of a severe allergic reaction include an itchy skin rash with hives, shortness of breath and difficulty breathing, along with swelling of the face, tongue and throat.