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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
Reasons to Give a Dog Aspirin. BananaStock/BananaStock/Getty Images. Aspirin is the only over-the-counter human pain reliever that is safe for use in dogs. If your dog is experiencing pain from a minor injury like a sprain or a strain, you can give him aspirin to relieve the pain and inflammation. Aspirin is also an acceptable choice for pain relief in dogs who have occasional bouts of arthritis.