Certain sub-stances in grapefruit juice block the action of CYP3A4, so instead of being metabolized, more of the drug enters the bloodstream and stays in the body longer. The result: potentially dangerous levels of the drug in your body. The amount of the CYP3A4 enzyme in the intestine varies from one per-son to another, says Huang. Some people have a lot, and others have just a littleâso grapefruit juice may affect people differently when they take the same drug.
3. Splitting Fruit. Like the foliage thatâs dying back, splitting tomato fruit is a sign of uneven watering. As the fruit is ripening if the plant receives too much water the skin will split because the fruitâs skin can no longer expand.
Perhaps the most common reason for tomato plant failure is disease. Tomato plants are susceptible to a wide variety of diseases. These include: 1  Alternaria Canker â Brown depressed spots on the leaves, fruit and stems.f, on the other hand, your tomato plants are in standing water or if the soil seems swampy, the plants may be overwatered. Poor soil is often characterized by poor growth, few and poor quality fruit and a stunted plant.