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1 Anxiety: An initial dose of 0.25 mg to 0.5 mg of Xanax is administered orally, three times a day. 2  The dose can be increased gradually every three to four days up to maximum daily dose of 4 mg in divided doses.3  Panic: An initial dose of 0.5 mg of Xanax is administered orally, three times a day. Depression: An initial dose of 0.5 mg of Xanax is administered orally three times a day. 2  The dose can be increased by no more than 1 mg every three to four days. 3  An average dose of 3 mg of Xanax daily in divided doses has shown to be most effective.
Doctors never recommend more than 2 mg of Xanax be taken at one time, thatâs only in someone with a tolerance for the medication. Starting doses of Xanax can be as low as 0.75 mg per day. Some people have reported taking up to 2000 mg of Xanax, with only minor toxicity.