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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
Dogs should only be given aspirin when they really need it, and not every time they are feeling slightly ill. Pet owners should administer aspirin with extreme caution, because large doses of aspirin can prove to be toxic for a dog. Smaller breeds of dogs especially are more prone to overdosing on aspirin. Always give your dog aspirin with food, and never on an empty stomach.