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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
Dogs that Can be Treated with Aspirin. Most dogs of any size can be given baby aspirin, as long as the dose is correctly calculated. However, according to It's a Dog's Life Toronto, young dogs should not be given aspirin because the enzymes needed to process the drug are not present in their bodies.