High PTH levels may be caused by: 1  A parathyroid gland growth (hyperplasia) or a parathyroid tumor. 2  A low level of calcium in the blood. 3  Some types of cancer, such as of the lung, kidney, pancreatic, or ovarian cancer.
MTOR inhibitors What are MTOR inhibitors. Mammalian target of rapamycin (mTOR) inhibitors block the activity of the mammalian target of rapamycin. Mammalian target of rapamycin is a protein kinase, which regulates growth factors that stimulate cell growth and angiogenesis. In certain cancers the mTOR pathway is more active. Mammalian target of rapamycin (mTOR) inhibitors are used in treatment of renal cancer and is being studied for use in other types of cancers.
AP23573, an mTOR inhibitor and rapamycin analog, which was granted fast-track designation by the FDA for patients with soft tissue and bone sarcomas, is a unique agent with promising efficacy in sarcoma.Registration trials of AP23573 in sarcoma are eagerly awaited.ll mTOR inhibitors bind to the mTOR kinase. This has at least two important effects. First, mTOR is a downstream mediator of the PI3K/Akt pathway. The PI3K/Akt pathway is thought to be over activated in numerous cancers and may account for the widespread response from various cancers to mTOR inhibitors.