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Intrinsic factor. Intrinsic factor (IF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B12 (cobalamin) later on in the small intestine. In humans, the gastric intrinsic factor protein is encoded by the GIF gene.
Intrinsic factor is a protein produced by cells in the stomach lining. The body needs it so the intestines can absorb vitamin B12. Stage II of the test can tell whether a low vitamin B12 level is caused by problems in the stomach, preventing it from producing intrinsic factor. If Stage II is abnormal, a Stage III test is done. Stage III: This test is done after you have taken antibiotics for 2 weeks.