Tofranil (imipramine): 1  Is generally used in children older than 6 years. 2  Has a success rate of 10 to 50 percent. 3  Starts working in a few days. 4  Is relatively inexpensive. 5  Will likely stop working when the child stops taking the medication.
The peak pressure is the pressure measured by the ventilator in the major airways, and it strongly reflects airways resistance. For example, in acute severe asthma, there is a large gradient between the peak pressure (high) and the plateau pressure (normal). In pressure controlled ventilation, the pressure limit is (usually) the plateau pressure due to the dispersion of gas in inspiration.
Now letâs go back to peak and plateau pressures: Peak inspiratory pressure (PIP) = plateau pressure (Pplat) + pressure required to overcome airway resistance. Consequently, plateau pressure can never be higher than the peak, because thereâs always going to be intrinsic resistance which must be overcome.