Certain sub-stances in grapefruit juice block the action of CYP3A4, so instead of being metabolized, more of the drug enters the bloodstream and stays in the body longer. The result: potentially dangerous levels of the drug in your body. The amount of the CYP3A4 enzyme in the intestine varies from one per-son to another, says Huang. Some people have a lot, and others have just a littleâso grapefruit juice may affect people differently when they take the same drug.
3. Splitting Fruit. Like the foliage thatâs dying back, splitting tomato fruit is a sign of uneven watering. As the fruit is ripening if the plant receives too much water the skin will split because the fruitâs skin can no longer expand.
Tomato plants thrive in full sun in humus-rich, well-drained soil with a pH between 6.0 and 6.8. Although tomato plants can tolerate slightly dry soil, they perform best when the soil remains evenly moist, as uneven watering can cause blossom-end rot and cat-facing in tomatoes.