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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
Follow On: Aspirin for dogs can be used in low doses as a pain killer and to reduce swelling. The medication is particularly effective in cases of joint and muscular pain. An alternative to aspirin would be steroids, but aspirin has the advantage of not having as many side effects.