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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
Side Effects of Aspirin for Dogs You may have heard people say that aspirin is safe to give to dogs. This is technically true, but only if you follow the advice of a veterinarian.