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As in the arteries, the walls of veins have three layers, or coats: an inner layer, or tunica intima; a middle layer, or tunica media; and an outer layer, or tunica adventitia. Each coat has a number of sublayers.
There are numerous causes for a swollen vein, including previous medical complications due to injuries directly to the veins, venous insufficiency and thrombosis, pregnancy, hypertension, and various side effects due to medications and allergic reactions. Swollen veins are usually categorized into two separate areas: varicose and spider veins.