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The most common and less serious side effects of metformin are bloating, gas, stomach pain, weakness, diarrhea, constipation, heartburn, sneezing, headaches, cough, flushing of the skin, vomiting, runny nose, nausea and muscle pain.
Metformin Side Effects: Prolonged Use Lead To Severe Side Effects. Metformin is a frontline diabetic drug prescribed by doctors to improve insulin resistance in the body. It is one of the most popular medicine for type-2 diabetes patients worldwide. However, according to a new research study, prolonged use of metformin can be a cause of side effects such as depression, loss of appetite, reduced mental ability to think clearly, fatigue and breathlessness.