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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
You'll also need to be aware of the appropriate dose of aspirin your dog needs to relieve his arthritis. Over dosage can be dangerous for your dog. A good rule of thumb is to give no more than 5mg per pound of your dog's body weight. Dosage and Frequency. Administer aspirin dosages no more often than every 12 hours.