Certain sub-stances in grapefruit juice block the action of CYP3A4, so instead of being metabolized, more of the drug enters the bloodstream and stays in the body longer. The result: potentially dangerous levels of the drug in your body. The amount of the CYP3A4 enzyme in the intestine varies from one per-son to another, says Huang. Some people have a lot, and others have just a littleâso grapefruit juice may affect people differently when they take the same drug.
3. Splitting Fruit. Like the foliage thatâs dying back, splitting tomato fruit is a sign of uneven watering. As the fruit is ripening if the plant receives too much water the skin will split because the fruitâs skin can no longer expand.
It is critical that gardeners understand that late blight is not like other tomato and potato diseases. Many other diseases affect these crops in home gardeners, but most of them only affect leaves or cause limited damage to fruit, and while they may reduce the harvest, they generally don't cause a total loss.