During this handshake, the client and server agree on various parameters used to establish the connection's security: 1  The handshake begins when a client connects to a TLS-enabled server requesting a secure connection and the client presents a list of supported cipher suites (ciphers and hash functions).
Allele frequency. Allele frequency is a term of population genetics that is used in characterizing the genetic diversity of a species population, or equivalently the richness of its gene pool.
When the allelic frequency in a population reaches 1.0, the allele is the only one left in the population, and it becomes fixed for that allele. The other allele is permanently lost. In populations in which an allele has become either fixed or lost, the process of random genetic drift stops at that locus. Without further input (mutation), the populations that have allelic frequencies of 1.0 or 0 for either allele will maintain those allelic frequencies forever.