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Stomach upset - Aspirin can upset a dog's stomach, which can interfere with the ultimate goal of relieving your dog's pain if he throws up the medication. Buffered aspirin is usually easier on a dog's stomach than non-buffered aspirin, especially if your vet advises you to give repeated doses.
0. You should never give aspirin to a dog. Aspirin is a blood thinner and, should your dog have a serious issue causing the pain, or need surgery, he could easily bleed too much. Consult a veterinarian. Most vets will charge a small exam fee and possibly prescribe a pain killer for your dog.