High PTH levels may be caused by: 1  A parathyroid gland growth (hyperplasia) or a parathyroid tumor. 2  A low level of calcium in the blood. 3  Some types of cancer, such as of the lung, kidney, pancreatic, or ovarian cancer.
MTOR inhibitors What are MTOR inhibitors. Mammalian target of rapamycin (mTOR) inhibitors block the activity of the mammalian target of rapamycin. Mammalian target of rapamycin is a protein kinase, which regulates growth factors that stimulate cell growth and angiogenesis. In certain cancers the mTOR pathway is more active. Mammalian target of rapamycin (mTOR) inhibitors are used in treatment of renal cancer and is being studied for use in other types of cancers.
A recent study provided evidence that the intracellular protein FKBP38 is an endogenous inhibitor of mTORC1 [ 46 ]. FKBP38 bound to the FRB domain of mTOR and inhibited its activity in vitro, similar to FKPB12/rapamycin.se of rapamycin plus an inhibitor of Akt or PI3K is one way to circumvent this problem, and another is to use a dual-specificity agent such as PI-103 that targets both PI3K and mTOR. Another strategy is to develop drugs that selectively target the mTOR kinase domain, which should inhibit both mTORC1 and mTORC2.