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Why is this medication prescribed? Verapamil is used to treat high blood pressure and to control angina (chest pain). The immediate-release tablets are also used alone or with other medications to prevent and treat irregular heartbeats. Verapamil is in a class of medications called calcium-channel blockers. It works by relaxing the blood vessels so the heart does not have to pump as hard. It also increases the supply of blood and oxygen to the heart and slows electrical activity in the heart to control the heart rate.
Keep in mind diltiazem and verapamil are inhibitors of 3A4. All CCBs are substrates of 3A4. Additionally, verapamil is also a substrate of CYP1A2, 2C9, and 2C19. 12 References: 1. Saskatchewan Formulary. Drug Plan and Extended Benefits Branch [homepage on the Internet].eep in mind diltiazem and verapamil are inhibitors of 3A4. All CCBs are substrates of 3A4. Additionally, verapamil is also a substrate of CYP1A2, 2C9, and 2C19. 12 References: 1. Saskatchewan Formulary. Drug Plan and Extended Benefits Branch [homepage on the Internet].