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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
degenerates; degenerated; degenerating. Learner's definition of DEGENERATE. [no object] : to change to a worse state or condition : to become worse, weaker, less useful, etc. As the disease progresses, the patient's health will degenerate [=deteriorate] rapidly.