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[edit on Wikidata] Pituitary ACTH hypersecretion (or Cushing disease) is a form of hyperpituitarism characterized by an abnormally high level of ACTH produced by the anterior pituitary. It is one of the causes of Cushing's syndrome. (However, Cushing's syndrome can be caused by many other causes, including exogenous administration.) ^ Drouin J, Bilodeau S, Vallette S (September 2007). Of old and new diseases: genetics of pituitary ACTH excess (Cushing) and deficiency.
Cushing's Disease (or syndrome) occurs when the adrenal glands produce excess amounts of cortisol, also known as cortisone. Cushing's is also known as hyperadrenocorticism. Hyper = above normal; adreno = relating to the adrenal glands; corticism = relating to the cortex & cortisol production. So, Cushings is a disease of elevated cortisol production by the adrenal cortex. Cushing's is much more common in dogs than in cats, so this page focuses on Cushings in dogs. Dogs have two adrenal glands, which are are small pea-sized glands located next to the kidneys.