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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
The half life of hydrocodone is 3.3 to 3.4 hours and a pill can have up to five half lives. So if you must take tramadol while on hydrocodone try to wait at least 4 hours between times.   You can take Tramadol if you have taken hydrocodone but the risk of seizure is much higher.Tramadol alone poses a higher risk for seizures by lowering your seizure threshold. So tramadol combined with hydrocodone does increase the risk for seizures.aroxetine (Pazil) can be taken with medications containing hydrocodone. Ultram (tramadol) is a selective mu-agonist and will compete for binding sites with hydrocodone, so it â¦ 's really best NOT to take them together.