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Usually, the dominant symptom of a swollen pancreas is abdominal pain. As pancreatitis involves an interruption of the digestive enzymesâ normal function, sufferers may also experience digestive problems such as nausea, vomiting, diarrhea, discolored waste, and unplanned weight loss.
Pancreatic Cancer: Whole-Body Symptoms. As it grows and spreads, pancreatic cancer affects the whole body. Such symptoms can include: 1  Weight loss. 2  Malaise. 3  Loss of appetite. 4  Elevated blood sugars. 5  Some people with pancreatic cancer develop diabetes as the cancer impairs the pancreas' ability to produce insulin.