Drugs versus Biologics. 1  A biologic is manufactured in a living system such as a microorganism, or plant or animal cells. 2  Most biologics are very large, complex molecules or mixtures of molecules.enerics Drugs versus Follow-On Biologics. 1  To be approved as a generic, a drug must have the same active ingredient, strength, dosage form, and route of administration as the reference drug, and it must also be bioequivalent..
Viruses (e.g., adenovirus, astrovirus, rotavirus, Norwalk virus) are the most common cause of diarrhea in the United States. The most common ones in children are rotavirus and in adults are norovirus. Escherichia coli, Clostridium difficile, and Campylobacter, Salmonella, and Shigella spp. are common bacterial causes.
The three types of diarrhea are: acute diarrhea, persistent diarrhea, and dysentery. If an episode of diarrhea lasts less than 14 days, it is acute diarrhea. Acute watery diarrhea causes dehydration and contributes to malnutrition. The death of a child with acute diarrhea is usually due to dehydration. If the diarrhea lasts 14 days or more, it is persistent diarrhea. Up to 20% of episodes of diarrhea become persistent. Persistent diarrhea often causes nutritional problems, creating the risk of malnutrition and serious non-intestinal infection.