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Vial: Once the vial is punctured, it is OPEN. Once you stick a needle in the vial, it is OPEN. OPEN vials can be stored in the fridge or at CONTROLLED room temperature. Regardless of where it is stored, OPEN insulin will only last 28 days before it must be thrown in the trash.
After all, the only difference between opened insulin and unopened insulin is that little cap over the stopper. Yes the stopper is more porous but if the bottle is sitting in the fridge unused I suspect it has quite a long shelf-life in the refrigerator. We used to keep backup bottles for months at a time. But every time you draw from it, you not only inject air and potentially contaminants into the bottle but may slightly change the mix of ultralente and semilente insulin. So the more it's used, to me, the more likely you need to shortcut the life of the bottle.