Points to consider prior to initiating RETROVIR in pregnant women for the prevention of maternal-fetal HIV-1 transmission include: â¢ In most cases, RETROVIR for prevention of maternal-fetal HIV-1 transmission should be given in combination with other antiretroviral drugs. â¢ Prevention of HIV-1 transmission in women who have received RETROVIR for a prolonged period before pregnancy has not been evaluated.
Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin trough levels is 10-20 Âµg/mL (15-20 Âµg/mL for complicated infections). The reference range for vancomycin peak levels is 25-50 Âµg/mL. Next. Vancomycin trough concentrations below 10 Âµg/mL are associated with inadequate therapy and an increased risk of developing bacterial resistance. Vancomycin trough concentrations above the therapeutic range may increase the risk of nephrotoxicity.
In subjects with normal kidney function, multiple intravenous dosing of 1 g of vancomycin (15 mg/kg) infused over 60 minutes produces mean plasma concentrations of approximately 63 mcg/mL immediately after the completion of infusion, mean plasma concentrations of approximately 23 mcg/mL 2 hours after infusion, and mean plasma concentrations of ...