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Lipase is a digestive enzyme produced by the following organs: pancreas (pancreatic lipase), liver (hepatic lipase), and stomach (stomach/gastric lipase). Enzymes are responsible for the metabolism of carbohydrates, proteins, and fats.
1 It is produced by the stomach cells called chief cells in its inactive form pepsinogen, which is a zymogen. 2  Pepsinogen is then activated by the stomach acid into its active form, pepsin. 3  Pepsin breaks down the protein in the food into smaller particles, such as peptide fragments and amino acids. Gastric Lipase: Gastric lipase is an acidic lipase secreted by the gastric chief cells in the fundic mucosa in the stomach. 2  It has a pH optimum of 3-6. 3  Gastric lipase, together with lingual lipase, comprise the two acidic lipases.