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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
The half life of tramadol is in the range of 5 to 8 hours,.. so the mean half life is about 6.3 hours (in the blood plasma) -- and it's metabolite(s) are around 6.8-7.5 hours. A 50mg dose of tramadol is distributed at a rate of about 1.3liters/kg and slightly higher for women.