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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
Tramadol is metabolised to O-desmethyltramadol, which is a more potent opioid. It is of the benzenoid class. Tramadol was launched and marketed as Tramal by the German pharmaceutical company Gruenenthal GmbH gmbh in 1977 In West, germany and 20 years later it was launched in countries such as THE, Uk.U., s And. australia