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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
Tramadol has a half-life of about 6.5 hours and will typically take anywhere from 2 to 4 days to clear your system to the point that itâs undetectable in a urine sample. As such anyone undergoing a urinalysis for opioids on short notice is going to be in a very tight spot.