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[edit on Wikidata] Pituitary ACTH hypersecretion (or Cushing disease) is a form of hyperpituitarism characterized by an abnormally high level of ACTH produced by the anterior pituitary. It is one of the causes of Cushing's syndrome. (However, Cushing's syndrome can be caused by many other causes, including exogenous administration.) ^ Drouin J, Bilodeau S, Vallette S (September 2007). Of old and new diseases: genetics of pituitary ACTH excess (Cushing) and deficiency.
When too much cortisol is present in the body, it is called Cushingâs syndrome, regardless of the cause. Cortisol is made by the adrenal glands which are stimulated by ACTH, which is produced in pituitary gland. When the cause of the excess cortisol is excess ACTH made by a pituitary tumor, the condition is called Cushingâs disease. Rarely, excess ACTH can be produced by a tumor elsewhere in the body, which is referred to as ectopic production of ACTH. Another cause of Cushing's syndrome can be taking excess steroid medications. Finally, excess production of cortisol by an adrenal tumor can lead to Cushing's syndrome.