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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
By: Kara McCarty El Segundo, CA. The shelf life of Tramadol is 36 months after its formulation, as long as it is stored in a cool, dark environment. If your dog is kept quiet, and his Tramadol is still good according to its expiration date, it's probably fine to give it to him as recommended by the label for a day or two.