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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
degenerative disease. a disease in which the sole pathogenesis is degeneration; that is without the intervention of other pathogeneses, e.g. inflammation, traumatic injury, neoplasia. degenerative joint disease. see degenerative joint disease.