While ALS is the most common motor neuron disease, we also treat all other forms, including: 1  PLS (Primary Lateral Sclerosis), affecting the upper motor neurons in the brain and spinal cord. 2  PMA (Primary Muscular Atrophy), affecting the lower motor neurons from the spine to the muscle.
Deletion Mutation and DNA. A deletion mutation occurs when part of a DNA molecule is not copied during DNA replication. This uncopied part can be as small as a single nucleotide or as much as an entire chromosome.The loss of this DNA during replication can lead to a genetic disease.eletion Mutation and DNA. A deletion mutation occurs when part of a DNA molecule is not copied during DNA replication. This uncopied part can be as small as a single nucleotide or as much as an entire chromosome.
A mutation is a change in a DNA sequence that alters the protein for which the DNA codes. Sometimes mutations occur due to damage from an outside source, such as ultraviolet radiation. Excess ultraviolet radiation from the sun sometimes causes mutations that lead a cell to become cancerous. Most mutations that damage a DNA strand are harmful. Other mutations occur due to deletion or insertion of DNA base pairs. One such deletion in humans confers HIV resistance or a delayed AIDS onset. Humans who are heterozygous for the mutation, meaning they possess one mutant gene and one normal gene, experience a slower progression of AIDS.