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The recommended starting dose of Zoloft for people with panic disorder, post-traumatic stress disorder (PTSD), or social anxiety disorder is Zoloft 25 mg once a day.
Increases should not exceed 50 mg and the dosage should not be changed more than once a week. The maximum dosage is 200 mg a day, though for these disorders a lower dosage is commonly used. Premenstrual Dysphoric Disorder. Zoloft can also be used to treat Premenstrual Dysphoic Disorder.