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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
To understand how long Tramadol is likely to stay in your system after stopping, it is necessary to consider its elimination half-life. Elimination half-life is the average amount of time it takes for 50% of the drug to have been cleared from your system.