The main symptom is pain over the outside of your upper thigh. Most cases are due to minor injury or inflammation to tissues in your upper, outer thigh area. Commonly the condition goes away on its own over time. Anti-inflammatory painkillers, physiotherapy and steroid injections can all sometimes help.
1 Remove any diseased or broken wood, plus crossing branches. You want the bush to have a narrow base and a wide, open top that allows sunlight and air in.  The best time to prune blueberry bushes is late winter while they're still dorant.
Then there is pruning tree roses as well as pruning knockout rose bushes. The signs for pruning rose bushes in the spring are the swelling of the rose buds. So therefore the best time to prune your roses is in early spring when those buds just begin to swell. Keep in mind that a rose is basically just a flowering shrub, and also that it's very hard to do any real harm to the rose bush if you do not prune like a pro the first time.