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In the most basic terms, genome is the genetic material of an organism. It is what tells the organism what to be and how to be. The genome is coded in DNA, or in RNA for many types of viruses. The term, genome, was coined in the 1920, as a portmanteau of gene and chromosome.
One set is inherited from the father, and one set is inherited from the mother. A DNA is a sort of a bio molecule. The entire DNA in cells can be found in individual pieces that are called chromosomes. The main difference between DNA and chromosome is regarding the role of genes. DNA stands for deoxyribonucleic acid.