While ALS is the most common motor neuron disease, we also treat all other forms, including: 1  PLS (Primary Lateral Sclerosis), affecting the upper motor neurons in the brain and spinal cord. 2  PMA (Primary Muscular Atrophy), affecting the lower motor neurons from the spine to the muscle.
Deletion Mutation and DNA. A deletion mutation occurs when part of a DNA molecule is not copied during DNA replication. This uncopied part can be as small as a single nucleotide or as much as an entire chromosome.The loss of this DNA during replication can lead to a genetic disease.eletion Mutation and DNA. A deletion mutation occurs when part of a DNA molecule is not copied during DNA replication. This uncopied part can be as small as a single nucleotide or as much as an entire chromosome.
Best Answer: Missense mutations With a missense mutation, the new nucleotide alters the codon so as to produce an altered amino acid in the protein product.Nonsense mutations With a nonsense mutation, the new nucleotide changes a codon that specified an amino acid to one of the STOP codons (TAA, TAG, or TGA).Therefore, translation of the messenger RNA transcribed from this mutant gene will stop prematurely.uch mutations are said to be silent because they cause no change in their product and cannot be detected without sequencing the gene (or its mRNA). Insertions and Deletions (Indels) Extra base pairs may be added (insertions) or removed (deletions) from the DNA of a gene. The number can range from one to thousands.