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Fluid-mosaic model. 1  Plasma membrane consists of a phospholipid bilayer studded with proteins, polysaccharides, lipids. 2  The lipid bilayer is semipermeable Regulates passage of substances into and out of the cell. H2O and some small, uncharged, molecules (O2, CO2) can pass through.
1 The plasma membrane acts as a partially permeable membrane and selectively controls the movement of substances in and out of a cell. 2  Factors that determine whether a molecule can pass through the plasma membrane are the size and polarity of the molecule.