Collagen is a natural protein component of the skin that acts like a scaffold and the main building block for cells, tissues and organs. About a third of the protein content in your body is made up of collagen, which is found in the bones, muscles, and tissues of the organs.
1 There can be the accumulation of fluid on the knee after an accident. 2  In most cases, the fluid is blood which can be through a fracture caused to the knee. 3  The swelling of the knee often takes place within some minutes of the injury occurring. 4  Gout and pseudo-gout can also cause fluid on the knee.
By Mayo Clinic Staff. A swollen knee occurs when excess fluid accumulates in or around your knee joint. Your doctor might refer to this condition as an effusion (ih-FYU-zhen) in your knee joint. Some people call this condition water on the knee.. A swollen knee may be the result of trauma, overuse injuries, or an underlying disease or condition. To determine the cause of the swelling, your doctor might need to obtain a sample of the fluid to test for infection, disease or injury.