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DRUG DESCRIPTION. WELLBUTRIN XLÂ® (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin reuptake inhibitor, or other known antidepressant agents. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines.
Implementation. 1  Do not confuse bupropion with buspirone. 2  Do not confuse Wellbutrin SR with Wellbutrin XL. 3  Do not confuse Zyban with Diovan. 4  Do not administer bupropion (Wellbutrin) with Zyban, which contain the same ingredients.