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In the most basic terms, genome is the genetic material of an organism. It is what tells the organism what to be and how to be. The genome is coded in DNA, or in RNA for many types of viruses. The term, genome, was coined in the 1920, as a portmanteau of gene and chromosome.
Also, nuclear DNA contains a nuclear genome while mtDNA contains a mitochondrial genome. Genome is the complete set of genetic material of an organism. One final difference in the structure is nuclear DNA contains three-billion nucleotides, and mtDNA only contains 16,569 nucleotides.