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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
degenerative disease. a disease in which the sole pathogenesis is degeneration; that is without the intervention of other pathogeneses, e.g. inflammation, traumatic injury, neoplasia. degenerative joint disease. see degenerative joint disease.degenerative left shift. an increase in immature neutrophilic granulocytes, in excess of mature cells of the series, with a normal or increased white blood cell count. A poor prognostic sign, indicating an inability of the bone marrow to respond adequately to infection.egenerative disease. a disease in which the sole pathogenesis is degeneration; that is without the intervention of other pathogeneses, e.g. inflammation, traumatic injury, neoplasia. degenerative joint disease. see degenerative joint disease.