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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
Hydrocodone is excreted in the urine and can be detected in urine drug tests. Hydrocodone is detectable in hair samples for several months after use. Acetaminophenâs half-life is 2-3 hours.ydrocodone has a half-life of 3 to 4 hours; thatâs how long it takes the body to eliminate half of the drug from the bloodstream. It takes several half-lives to eliminate all the hydrocodone.