Just a couple of thoughts. As cells get bigger, the components (used to be called organelles but I guess that's changed) get further from the cell walls or membranes.
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Middlesex Canal, Lock-keeper's House, Gillis Lock, Shawsheen Avenue, Wilmington, Middlesex County, MA Photo(s): 1 Contributor: Historic American Buildings Survey Photo, Print, Drawing Middlesex Canal, Nichols Lock, Nichols Street, Wilmington, Middlesex County, MA