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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
Best Answer: Tramadol reaches peak plasma levels roughly 2 hours post medicinal ingestion. It is metabolized renally (via the kidneys) into O-desmethyltramadol which is the active metabolite for detection and what is active for it's analgesic and SSRI properties across the body/brain.