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In the most basic terms, genome is the genetic material of an organism. It is what tells the organism what to be and how to be. The genome is coded in DNA, or in RNA for many types of viruses. The term, genome, was coined in the 1920, as a portmanteau of gene and chromosome.
â¢ Gene is a segment or a portion of DNA molecule while genome is the total DNA content in a cell. â¢ Genes code for proteins. Genome itself cannot code for proteins as it contains almost all the DNA. Since the gene is only a portion of a DNA molecule, that part is enough to code for proteins.sually these characteristics are encoded in the DNA (deoxyribonucleic acid) molecules present in their cells. Gene properties and genome properties vary widely from one species to another.