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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
Medical Definition of DEGENERATIVE DISEASE. : a disease (as arteriosclerosis, diabetes mellitus, or osteoarthritis) characterized by progressive degenerative changes in tissue. 2 ENTRIES FOUND: 1  degenerative disease (noun). 2  degenerative joint disease (noun). a disease (as arteriosclerosis, diabetes mellitus, or osteoarthritis) characterized by progressive degenerative changes in tissue. 2 ENTRIES FOUND: 1  degenerative disease (noun).