In which case, it depends on the type of inhibitor. A competitive inhibitor has a structure similar to the substrate, hence would bind to the active site as well, competing with the substrate for the enzyme active sites, decreasing enzymatic activity. A non-competitive inhibitor binds to the allosteric site of the enzyme, causing a structural change in the enzyme active site shape.
There's a difference between the effects of cold-brewed coffee vs. hot-brewed coffee: because different chemical reactions are achieved at higher temperatures, cold-brewed coffee will have a smoother caffeine effect and overall less acidity, which some people experience as part of the kick..
Some people's eyes can easily get puffy if they drink coffee because their body system can cope with that much coffeine, then puffy eyes appear as a symptom. On the contrary, other people can drink coffee to cure puffy eyes. Because coffee can help people letting the extra liquid out of our body. No matter what, do not drink coffee before sleep.