In which case, it depends on the type of inhibitor. A competitive inhibitor has a structure similar to the substrate, hence would bind to the active site as well, competing with the substrate for the enzyme active sites, decreasing enzymatic activity. A non-competitive inhibitor binds to the allosteric site of the enzyme, causing a structural change in the enzyme active site shape.
There's a difference between the effects of cold-brewed coffee vs. hot-brewed coffee: because different chemical reactions are achieved at higher temperatures, cold-brewed coffee will have a smoother caffeine effect and overall less acidity, which some people experience as part of the kick..
The Cancer Research. Coffee contains a variety of phytochemicals, many of which have antioxidant properties. Coffee's possible link to cancer is a well studied one, with over 1,000 studies on the topic. Early in the research, some studies hinted that coffee might increase cancer risk. Larger and more well-designed studies now suggest the opposite: it may be protective for some cancers.