While ALS is the most common motor neuron disease, we also treat all other forms, including: 1  PLS (Primary Lateral Sclerosis), affecting the upper motor neurons in the brain and spinal cord. 2  PMA (Primary Muscular Atrophy), affecting the lower motor neurons from the spine to the muscle.
Deletion Mutation and DNA. A deletion mutation occurs when part of a DNA molecule is not copied during DNA replication. This uncopied part can be as small as a single nucleotide or as much as an entire chromosome.The loss of this DNA during replication can lead to a genetic disease.eletion Mutation and DNA. A deletion mutation occurs when part of a DNA molecule is not copied during DNA replication. This uncopied part can be as small as a single nucleotide or as much as an entire chromosome.
Missense Mutation Example. Remember, a missense mutation is a mutation in which one DNA nucleotide is switched out with another one in a way that changes the amino acid specified. When a missense mutation occurs in a DNA molecule, it changes one of the RNA codon sequences made during transcription. This different codon will then cause a different amino acid to be inserted into a protein during translation.