Just a couple of thoughts. As cells get bigger, the components (used to be called organelles but I guess that's changed) get further from the cell walls or membranes.
Haverhill, Essex County, Massachusetts: Browse Thousands of Acres of Land for Sale in Haverhill, Essex County, Massachusetts.
To the north of Hampden County is modern-day Hampshire County; to the west is Berkshire County; to the east is Worcester County; to the south are Litchfield County, Hartford County, and Tolland County in Connecticut. Hampden County is part of the Springfield, MA Metropolitan Statistical Area. It is the most urban county in Western Massachusetts. The Knowledge Corridor surrounding Springfield-Hartford is New England's second most populous urban area (after Greater Boston) with 1.9 million people.