In which case, it depends on the type of inhibitor. A competitive inhibitor has a structure similar to the substrate, hence would bind to the active site as well, competing with the substrate for the enzyme active sites, decreasing enzymatic activity. A non-competitive inhibitor binds to the allosteric site of the enzyme, causing a structural change in the enzyme active site shape.
There's a difference between the effects of cold-brewed coffee vs. hot-brewed coffee: because different chemical reactions are achieved at higher temperatures, cold-brewed coffee will have a smoother caffeine effect and overall less acidity, which some people experience as part of the kick..
A person with allergy symptoms after drinking decaffeinated coffee would likely be allergic to coffee, while a person with allergy symptoms after drinking other caffeinated beverages (such as cola, tea or chocolate) would more likely have a caffeine allergy. So, next time youâre at the local coffee shop, get the large size coffee.