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DRUG DESCRIPTION. WELLBUTRIN XLÂ® (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin reuptake inhibitor, or other known antidepressant agents. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines.
Currently, no antidepressant medications are classified in pregnancy category B. <br /><br /> Wellbutrin (bupropion) is the only antidepressant that was classified by the FDA in pregnancy category B, in the past. However, it has now been assigned by the FDA to category C. Fluoxetine, desipramine, phenelzine, sertraline, trazodone, nefazodone, venlafaxine, and mirtazapine by the FDA are classified in pregnancy category C. Paroxetine, amitriptyline, imipramine, and nortriptyline are classified iby the FDA in pregnancy Category D with positive evidence of human fetal risk.