The neuromuscular junction is the site of the signal exchange. The steps of this process in vertebrates occur as follows:(`) The action potential reaches the axon terminal. (2) Voltage-dependent calcium gates open, allowing calcium to enter the axon terminal.he neuromuscular junction is the site of the signal exchange. The steps of this process in vertebrates occur as follows:(`) The action potential reaches the axon terminal. (2) Voltage-dependent calcium gates open, allowing calcium to enter the axon terminal.
Sudden onset pain on the outer side of the foot can be from a fracture of the 5th Metatarsal and injuries to this bone are a common sports injury. Causes of pain on the outside of the foot are listed here: 1  Midtarsal Joint Sprain A mid tarsal joint sprain is an injury to the ligaments holding the mid tarsal joint together causing pain in the outside middle of the foot. 2  Peroneus Brevis Tendon Injury The Peroneus Brevis tendon inserts into the 5th matatarsal bone on the outside of the foot.
Lower Back and Leg pain. Lower back and leg pain go hand and glove together; an irritated or pinched nerve causes tingling, numbness and a deep ache in the limb. FEMORAL NERVE : Roots L2, L3 & L4 (front and side of the thigh pain especially) SCIATIC NERVE : Roots L4, L5 & S1 mainly (lower leg and foot pain especially)