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DRUG DESCRIPTION. WELLBUTRIN XLÂ® (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin reuptake inhibitor, or other known antidepressant agents. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines.
Bupropion (Wellbutrin) is a NDRI (norepinephrine-dopamine reuptake Inhibitor). Reuptake Inhibitors are thought to block the reabsorption (reuptake) of the targeted neurotransmitter by certain nerve cells in the brain. This theoretically leaves more of the neurotransmitter in the brain.