While ALS is the most common motor neuron disease, we also treat all other forms, including: 1  PLS (Primary Lateral Sclerosis), affecting the upper motor neurons in the brain and spinal cord. 2  PMA (Primary Muscular Atrophy), affecting the lower motor neurons from the spine to the muscle.
Deletion Mutation and DNA. A deletion mutation occurs when part of a DNA molecule is not copied during DNA replication. This uncopied part can be as small as a single nucleotide or as much as an entire chromosome.The loss of this DNA during replication can lead to a genetic disease.eletion Mutation and DNA. A deletion mutation occurs when part of a DNA molecule is not copied during DNA replication. This uncopied part can be as small as a single nucleotide or as much as an entire chromosome.
A missense mutation is when the change of a single base pair causes the substitution of a different amino acid in the resulting protein.This amino acid substitution may have no effect, or it may render the protein nonfunctional. single base pair substitution that results in the translation of a different amino acid at that position. Definition from: GeneReviews from the University of Washington and the National Center for Biotechnology Information.