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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
Definition of degeneration 1: degenerate (see 1 degenerate) condition 2: a lowering of effective power, vitality, or essential quality to an enfeebled and worsened kind or state