Many urban legends are framed as complete stories with plot and characters. The compelling appeal of a typical urban legend is its elements of mystery, horror, fear or humor.Often they serve as cautionary tales.ecause people frequently allege that such tales happened to a  friend of a friend  (FOAF), the phrase has become a commonly used term when recounting this type of story. Sometimes urban legends are repeated in news stories, or distributed by e-mail or social media.
We have mast cells in the stomach wall. Somastatain-which is produced from d cells in the stomach wall is a known mast cell activator. We also know stress-in particular substance p and CRH also cause mast cells to spill contents. Histamine which we know is a chemical constantly released.
Histamine is present abundantly in the granules of tissue mast cells and circulating basophils. One of the stimuli that activate mast cells and basophils to release histamine is the binding of antigens to cell-bound IgE antibodies on the surfaces of mast cells and basophils.nother stimulus that activates mast cells to release histamine is the binding of C3a and C5a fragments of complement to specific receptors on mast cells. Activated mast cells release massive amounts of histamine into the surrounding tissue.