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Lipase is a digestive enzyme produced by the following organs: pancreas (pancreatic lipase), liver (hepatic lipase), and stomach (stomach/gastric lipase). Enzymes are responsible for the metabolism of carbohydrates, proteins, and fats.
There are four types of cells in the stomach: 1  Parietal cells: Produce hydrochloric acid and intrinsic factor. 2  Gastric chief cells: Produce pepsinogen. 3  Chief cells are mainly found in the body of stomach, which is the middle or superior anatomic portion of the stomach. Gastric Lipase: Gastric lipase is an acidic lipase secreted by the gastric chief cells in the fundic mucosa in the stomach. 2  It has a pH optimum of 3-6. 3  Gastric lipase, together with lingual lipase, comprise the two acidic lipases.