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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
Generally speaking, it takes five half-lives to fully eliminate a drug from your blood or urine. Flexeril has a half-life of 18 hours, so it would take 3.75 days for it to clear out of your body completely. Keep in mind that half-life can vary from patient to patient, so this is not a hard and fast rule. Half-life is also affected if the patient has altered kidney or liver function.