In which case, it depends on the type of inhibitor. A competitive inhibitor has a structure similar to the substrate, hence would bind to the active site as well, competing with the substrate for the enzyme active sites, decreasing enzymatic activity. A non-competitive inhibitor binds to the allosteric site of the enzyme, causing a structural change in the enzyme active site shape.
There's a difference between the effects of cold-brewed coffee vs. hot-brewed coffee: because different chemical reactions are achieved at higher temperatures, cold-brewed coffee will have a smoother caffeine effect and overall less acidity, which some people experience as part of the kick..
Here are just a few of the studies that support the notion that caffeinated coffee reduces risk of certain types of cancer. 1  Oral Cancer: More than 4 cups of coffee a day decrease oral and head cancers by 39%. 2  Uterine Cancer: Woman who drink more than two cups of coffee a day have less chance of uterine cancer.