Organ pipes are generally made out of either metal or wood. Very rarely, glass, porcelain, plastic, paper, Papier-mÃ¢chÃ©, or even stone pipes may be seen. A historical organ in the Philippines has pipes made exclusively of bamboo. Metal pipes are usually made of lead; for increased rigidity it is alloyed with tin along with trace amounts of antimony and copper.
Lyme Disease IgM antibodies usually appear 1-2 weeks after an initial exposure and return to normal after about 6 to 8 weeks. IgG antibodies are detectable in most people 4-6 weeks after exposure but may be detectable sooner in some people. IgG antibodies may persist indefinitely.
mg/ml) of the antibody in the serum. The fivemonomeric IgM molecules are arranged radially, theFab fragments pointing outward and the Fc fragmentspointing to the center of the circle (Figure 4-10). IgM isthe first antibody to appear during an immune re-sponse and the first formed by a developing fetus. Be-cause of its many antigen-binding sites, IgM canquickly clump antigen and efficiently activate comple-ment. IgM acts as one of the main receptors on the sur-face of mature B cells, along with IgD.