Drugs versus Biologics. 1  A biologic is manufactured in a living system such as a microorganism, or plant or animal cells. 2  Most biologics are very large, complex molecules or mixtures of molecules.enerics Drugs versus Follow-On Biologics. 1  To be approved as a generic, a drug must have the same active ingredient, strength, dosage form, and route of administration as the reference drug, and it must also be bioequivalent..
Acute watery diarrhea is most commonly seen with traveler's diarrhea caused by enterotoxigenic E. coli (ETEC), parasite-induced diarrhea from Giardia and Cryptosporidium spp. and, in cases of food poisoning (ingestion of preformed toxins), from B. cereus and S. aureus.
Numerous bacteria, viruses, and parasites cause diseases in the intestines that result in diarrhea, dysentery, constipation or perianal irritation. They may also cause nausea, vomiting, and abdominal cramping. If the infection is in the small intestine, symptoms include watery diarrhea and vomiting. Infections in the large intestine can cause diarrhea and can result in an invasive and inflammatory disease called dysentery (small fecal volume with mucus and blood) (Table SI-1). Table SI-1.