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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
Degenerative disc disease. Degenerative disc disease (DDD) describes the natural breakdown of an intervertebral disc of the spine. Despite its name, DDD is not considered a disease, nor is it progressively degenerative.