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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
The half-life of a drug is the time it takes your body to metabolize and excrete the medication, so that half of it is removed from your body. Generally speaking, it takes five half-lives to fully eliminate a drug from your blood or urine. Flexeril has a half-life of 18 hours. The drug stays active for about 5 half-lives. Therefore, the time to metabolise will be 5 times 18 hours. So it will take 90 hours before nearly all of it is out of your system. This equates to 3.75 days for it to clear out of your body completely. This half-life time can vary from person to person, and will depend on how much of a dosage was ingested, and both the personâs weight and metabolism.