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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
Definition of degeneration. 1 : degenerate (see 1degenerate) condition. 2 : a lowering of effective power, vitality, or essential quality to an enfeebled and worsened kind or state the country's degeneration into chaos â¦ enacts the degeneration of politics into televisual entertainment â¦ â Linda Holt.