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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
Share this conversation. Expert: hersheydoc replied 6 years ago. flexeril is primarily excreted in the urine. it has a half life of 18 hours. in medicine a drug has 3% remaining in the body after 5 half lives. we feel that the drug is essentially gone at this point.