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The recommended starting dose of Zoloft for people with panic disorder, post-traumatic stress disorder (PTSD), or social anxiety disorder is Zoloft 25 mg once a day.
People taking Zoloft and wondering how long does it take zoloft to work would generally begin to see changes like increase appetite, reduced sleep disturbances etc in the first one to two week. In another three to six weeks, severe symptoms of mental health would start to abate gradually and there would be lessening compulsive behavior etc. Zoloft can be a healthy and safe long term medication but has to be done under the guidance of a competent doctor.