In which case, it depends on the type of inhibitor. A competitive inhibitor has a structure similar to the substrate, hence would bind to the active site as well, competing with the substrate for the enzyme active sites, decreasing enzymatic activity. A non-competitive inhibitor binds to the allosteric site of the enzyme, causing a structural change in the enzyme active site shape.
There's a difference between the effects of cold-brewed coffee vs. hot-brewed coffee: because different chemical reactions are achieved at higher temperatures, cold-brewed coffee will have a smoother caffeine effect and overall less acidity, which some people experience as part of the kick..
Some people consider coffee to be a health drink, but like most foods, over indulging can cause side effects. For example, too much caffeine can give you headaches. This is primarily linked to caffeine withdrawal.The blood vessels in your brain become used to caffeineâs effects so if you suddenly stop consuming caffeine, it can cause a headache.