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[edit on Wikidata] Pituitary ACTH hypersecretion (or Cushing disease) is a form of hyperpituitarism characterized by an abnormally high level of ACTH produced by the anterior pituitary. It is one of the causes of Cushing's syndrome. (However, Cushing's syndrome can be caused by many other causes, including exogenous administration.) ^ Drouin J, Bilodeau S, Vallette S (September 2007). Of old and new diseases: genetics of pituitary ACTH excess (Cushing) and deficiency.
Causes are: (1) excessive secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland, which may actually result from faulty release of corticotropin-releasing factor (CRF) from the hypothalamus or a functional tumor, usually corticotroph adenoma; (2) tumor of the adrenal cortex, causing hypersecretion of the glucocorticoids; (3) iatrogenic Cushing's syndrome resulting from excessive or prolonged administration of exogenous glucocorticoids; and in humans (4) ectopic production ...