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The recommended starting dose of Zoloft for people with panic disorder, post-traumatic stress disorder (PTSD), or social anxiety disorder is Zoloft 25 mg once a day.
Major Depressive Disorder and Obsessive-Compulsive Disorder. ZOLOFT treatment should be administered at a dose of 50 mg once daily. ZOLOFT treatment should be initiated with a dose of 25 mg once daily. After one week, the dose should be increased to 50 mg once daily.