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Medical Definition of degenerative. : of, relating to, involving, or tending to cause degeneration degenerative conditions of the nervous systemâMorris Fishbein degenerative changes a degenerative muscle disorder.
Wiktionary (0.00 / 0 votes) Rate this definition: degenerate (Noun). One is degenerate, who has fallen from previous stature. You are a degenerate, boy. You're a disgrace to your ancestors.