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The recommended starting dose of Zoloft for people with panic disorder, post-traumatic stress disorder (PTSD), or social anxiety disorder is Zoloft 25 mg once a day.
Consequently, a dose of 50 mg, administered once daily, is recommended as the initial therapeutic dose. Patients not responding to a 50 mg dose may benefit from dose increases up to a maximum of 200 mg/day. Given the 24 hour elimination half-life of ZOLOFT, dose changes should not occur at intervals of less than 1 week.