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[edit on Wikidata] Pituitary ACTH hypersecretion (or Cushing disease) is a form of hyperpituitarism characterized by an abnormally high level of ACTH produced by the anterior pituitary. It is one of the causes of Cushing's syndrome. (However, Cushing's syndrome can be caused by many other causes, including exogenous administration.) ^ Drouin J, Bilodeau S, Vallette S (September 2007). Of old and new diseases: genetics of pituitary ACTH excess (Cushing) and deficiency.
Hypersecretion of cortisol from the adrenal cortex produces a complex of symptoms called Cushin syndrome. Someone with Cushing's will typically display obesity; a round, moon-like appearance of the fac; and fatty deposits on the chest, abdomen, and upper back.