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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
Immediate release tramadol lasts for 4-6 hours. Extended release tramadol lasts for 24 hours. More here on the duration of action for tramadol, tramadol addictive properties and a place at the bottom for your tramadol questions.