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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
Because tramadol can sometimes cause feelings of euphoria, and tramadol dependence time occurs within 3-4 weeks of use, tramadol is only available and used legally with a prescription from a medical doctor.Tramadol prescription dosageTramadol duration of action for immediate release versions is around 4-6 hours.ramadol prescription dosage. Tramadol duration of action for immediate release versions is around 4-6 hours. Doctors will usually start patients on 25 mg of tramadol. Eventually, you may end up taking 50 mg â 100 mg doses not more than 4 times a day.