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The mean terminal plasma elimination half-lives of racemic tramadol and racemic M1 are 6.3Â±1.4 and 7.4Â±1.4 hours, respectively. The plasma elimination half-life of racemic tramadol increased from approximately six hours to seven hours upon multiple dosing.
The effects of drugs are measured in half-life which is the amount of time it takes for half of the drug dosage to be eliminated from your system. The fentanyl transdermal system (Duragesic patch) has a half-life of 17 hours.It is strongly recommended that patients not combine other opiods (like Percocet) with the patch, as this can result in an overdose. If her symptoms continue she should notify her doctor.Source(s): http://www.rxlist.com/cgi/generic/fentan...est Answer: Hi, Fentanyl has a half-life of about 7 hours (ie after 7 hours, half the drug remains. After another 7 hours, half of that ....etc). But the patches work by releasing fentanyl into body fats, which then slowly release the drug into the blood stream over 72 hours.