In which case, it depends on the type of inhibitor. A competitive inhibitor has a structure similar to the substrate, hence would bind to the active site as well, competing with the substrate for the enzyme active sites, decreasing enzymatic activity. A non-competitive inhibitor binds to the allosteric site of the enzyme, causing a structural change in the enzyme active site shape.
There's a difference between the effects of cold-brewed coffee vs. hot-brewed coffee: because different chemical reactions are achieved at higher temperatures, cold-brewed coffee will have a smoother caffeine effect and overall less acidity, which some people experience as part of the kick..
1 Coffee acts as a laxative, stimulating your intestines to empty. 2  If you arenât suffering from constipation, too much coffee can produce loose bowel movements. 3  Coffee also can irritate your bladder and prostate gland. 4  Decaffeinated coffee actually may exacerbate these conditions.