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The recommended starting dose of Zoloft for people with panic disorder, post-traumatic stress disorder (PTSD), or social anxiety disorder is Zoloft 25 mg once a day.
1 Sertraline (Zoloft) is used to treat depression, OCD and many other conditins in adults, and severe OCD in children. 2  The usual dose of sertraline is 50 mg. 3  The dose can be increased if needed.herapy is usually started at 50 mg/day and the dose is increased at weekly intervals if necessary. The maximum dose is 200 mg/day. Children and older people often need smaller doses of medication and may start with 25 mg/day. People with liver disease may need a smaller dose of sertraline.