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Fluid-mosaic model. 1  Plasma membrane consists of a phospholipid bilayer studded with proteins, polysaccharides, lipids. 2  The lipid bilayer is semipermeable Regulates passage of substances into and out of the cell. H2O and some small, uncharged, molecules (O2, CO2) can pass through.
It separates the contents of the cell from its outside environment and it regulates what enters and exits the cell. Plasma membrane plays a vital role in protecting the integrity of the interior of the cell by allowing only selected substances into the cell and keeping other substances out.