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DNA is a polar molecule because it has a negatively (-) charged phosphate group attached to the 5' end of the molecule and a negatively charge hydroxl group (OH) attached to t â¦ he 3' prime end of the molecule. Thus, it is a POLAR molecule which allows it to interact in an aqueous environment.NA is a polar molecule because it has a negatively (-) charged phosphate group attached to the 5' end of the molecule and a negatively charge hydroxl group (OH) attached to t â¦ he 3' prime end of the molecule.
(Think of a base pair as a single molecule.). In double-stranded DNA the base stacking interactions lock in the helix and the cumulative cooperative effect is enormous compared to the more flexible single strands.This is why DNA renaturation is enthalpically driven whereas protein folding is entropically driven.. The stability conferred by each hydrogen bond is the difference between the strength of the bond in double-stranded DNA and its strength in when bonded to water. Hydrogen bonds between bases and water molecules typically have strengths of about 25 kJ mol -1 and hydrogen bonds between base pairs are a bit higher.