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These medicines may include: 1  Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, indomethacin, or naproxen. 2  Do not take aspirin, which should never be used to relieve pain during a gout attack. 3  Aspirin may change uric acid levels in the blood and may make the attack worse. 4  Be safe with medicines.his can reduce how often you have gout attacks and how severe they are. These medicines may include: 1  Uricosuric agents, to increase elimination of uric acid by the kidneys. 2  Xanthine oxidase inhibitors, to decrease production of uric acid by the body.
After an acute gout attack resolves, your doctor may prescribe a low daily dose of colchicine to prevent future attacks. Corticosteroids. Corticosteroid medications, such as the drug prednisone, may control gout inflammation and pain. Corticosteroids may be administered in pill form, or they can be injected into your joint. Corticosteroids are generally reserved for people who can't take either NSAIDs or colchicine.