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Surrounding each muscle fiber (cell) is a delicate external lamina composed primarily of reticular fibers. This external lamina is produced by the muscle fiber and, when observed through the light microscope, cannot be distinguished from the cell membrane of the muscle fiber, the sarcolemma.
In the peripheral nervous system, nerve fibers are each wrapped in a protective sheath known as the endoneurium. These are bundled together into groups known as fascicles, each surrounded by a protective sheath known as the perineurium. Several fascicles may be in turn bundled together with a blood supply and fatty tissue within yet another sheath, the epineurium. This grouping structure is analogous to the muscular organization system of epimysium, perimysium and endomysium.