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Causes of sepsis. Sepsis can be triggered by an infection in any part of the body. The most common sites of infection leading to sepsis are the lungs, urinary tract, tummy (abdomen) and pelvis. Sepsis may develop when you're already in hospital. For example, you're more likely to develop sepsis if:
In the worst cases, sepsis leads to a life-threatening drop in blood pressure. Doctors call this âseptic shock.â It can quickly lead to the failure of several organs -- lungs, kidneys, and liver. This can be fatal in some cases. Sepsis Causes and Risk Factors. Bacterial infections are most often to blame. But sepsis can also result from other infections. It can begin anywhere bacteria or viruses enter the body. So, it could sometimes be caused by something as minor as a scraped knee or nicked cuticle.