Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Common causes of pain in either big toe include turf toe, sesamoiditis, osteoarthritis or jamming the big toe into a wall or other hard surface, according to WebMD, Healthline and the American College of Foot and Ankle Surgeons.