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Causes of sepsis. Sepsis can be triggered by an infection in any part of the body. The most common sites of infection leading to sepsis are the lungs, urinary tract, tummy (abdomen) and pelvis. Sepsis may develop when you're already in hospital. For example, you're more likely to develop sepsis if:
Topic Overview. Sepsis is an extreme immune system response to an infection that has spread throughout the blood and tissues. Severe sepsis, also called septic shock, often causes extremely low blood pressure, which limits blood flow to the body and can result in organ failure and death.epsis is most often the result of a bacterial infection, but it can also be caused by other types of infection. Sepsis can occur in people of any age, but it is more common in infants, older adults, and people who have compromised immune systems.