Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
The second and much rarer condition is a genetic disease of purine metabolism that causes acute severe red-hot swelling appearing at the base of the big toe with excruciating pain and inability to walk, usually associated with fever or a feverish feeling.