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1 People often experience an upset stomach, diarrhea (possibly bloody), abdominal pain and painful swallowing when using aspartame as a sweetener.  Skin and Allergies. Hives and intense itching, lip or mouth swelling and worsening of asthma all can occur due to aspartame.
Other drugs, such as aspirin and other anti-inflammatory agents, while best absorbed without food, are so irritating to the stomach that they can cause pain, diarrhea, and nausea (Table 1). Effects of Alcohol, Caffeine, and Tea. Alcohol, caffeine, and some teas can increase the effect of certain drugs.