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1 People often experience an upset stomach, diarrhea (possibly bloody), abdominal pain and painful swallowing when using aspartame as a sweetener.  Skin and Allergies. Hives and intense itching, lip or mouth swelling and worsening of asthma all can occur due to aspartame.
Salmonella, a common cause of food poisoning, can cause diarrhea and fatigue. Colon cancer may cause rectal bleeding, diarrhea and fatigue. Dehydration can cause extreme fatigue. People who drink excessive alcohol often experience nausea and fatigue the next day. Food poisoning can cause cramps, diarrhea, and fatigue.