Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Turf toe is a painful sprain in the big toe causing sudden pain and swelling in the base of the big toe. A bunion is a bony bump at the base of the big toe and causes redness, numbness, burning and joint pain. Gout is a buildup of uric acid in the joints, causing joint pain, fever, and hot, red, swollen joints. Frostbite happens when the skin and the tissue freezes, causing pins and needles, numbness, and pain.