Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
A: Pain, numbness and tingling in either big toe can be due to many factors or conditions, including an injury, prolonged sitting in the same position and shoes that fit poorly, according to HealthGrades. Other possibilities include impaired blood circulation, nerve damage from temperature extremes or toxic substances, and peripheral neuropathy.