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Medical Definition of Immunosuppression. Immunosuppression: Suppression of the immune system and its ability to fight infection. Immunosuppression may result from certain diseases, such as AIDS or lymphoma, or from certain drugs, such as some of those used to treat cancer. Immunosuppression may also be deliberately induced with drugs, as in preparation for bone marrow or other organ transplantation, to prevent the rejection of a transplant.
Immunosuppressive agents are drugs that suppress the immune system and reduce the risk of rejection of foreign bodies such as transplant organs. Different classes of immunosuppressive agents have different mechanism of action. Now immunosuppressive agents are used as cancer chemotherapy, in autoimmune diseases such as rheumatoid arthritis and to treat severe allergy. As immunosuppressive agents lower the immunity there is increased risk of infection. Please refer to the drug classes listed below for further information.