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1 People often experience an upset stomach, diarrhea (possibly bloody), abdominal pain and painful swallowing when using aspartame as a sweetener.  Skin and Allergies. Hives and intense itching, lip or mouth swelling and worsening of asthma all can occur due to aspartame.
Hello, Possibility of any drug causing hives or an allergic reaction can be there in an individual even if he was previously using it.Tramadol can cause itching, sweating, dry mouth, diarrhea, rash and host of other side effects. The other possibility is of exercise induced urticaria or hives.