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1 People often experience an upset stomach, diarrhea (possibly bloody), abdominal pain and painful swallowing when using aspartame as a sweetener.  Skin and Allergies. Hives and intense itching, lip or mouth swelling and worsening of asthma all can occur due to aspartame.
You may know aspartame by one of its brand names: NutraSweet or Equal. Aspartame is also used widely in products like diet drinks, yogurt, chewing gum, and cereals. The ingredients of aspartame are aspartic acid and phenylalanine. Both are naturally occurring amino acids.