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Generic Name: glipizide (GLIP i zide) Brand Names: GlipiZIDE XL, Glucotrol, Glucotrol XL. Do not use this medication if you are allergic to glipizide, or if you are in a state of diabetic ketoacidosis. Call your doctor for treatment with insulin.
Sitagliptin is as effective as glipizide at lowering blood sugar levels in patients with type 2 diabetes and chronic kidney disease. Sitagliptin is less likely than glipizide to cause dangerously low blood sugar levels. Patients on sitagliptin tend to lose weight, while those on glipizide gain weight. Some blood-sugar-lowering drugs have caused kidney problems in patients with type 2 diabetes, so physicians are especially cautious when prescribing these agents to diabetics who also have chronic kidney disease (CKD). Previous research indicates that the diabetes drugs sitagliptin and glipizide may not cause considerable kidney damage. New clinical trial results presented during the American Society of Nephrology's Annual Kidney Week compared the two drugs.