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Causes of sepsis. Sepsis can be triggered by an infection in any part of the body. The most common sites of infection leading to sepsis are the lungs, urinary tract, tummy (abdomen) and pelvis. Sepsis may develop when you're already in hospital. For example, you're more likely to develop sepsis if:
Sepsis: The Basics. Sepsis is an extreme response to an infection. Your body sends a flood of chemicals into your bloodstream to fight the threat. This causes widespread inflammation which, over time, can slow blood flow and damage your organs. Sometimes sepsis can be life-threatening, especially if it moves to its later stages -- severe sepsis or septic shock.