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1 People often experience an upset stomach, diarrhea (possibly bloody), abdominal pain and painful swallowing when using aspartame as a sweetener.  Skin and Allergies. Hives and intense itching, lip or mouth swelling and worsening of asthma all can occur due to aspartame.
It also has weak antibacterial qualities against bacteria such as Heliobacter. The salicylate component (salicylate is a substance similar to aspirin) seems to have a slight antiprostaglandin effect, assisting in the treatment of some types of diarrhea. Prostaglandins are hormone-like substances that promote the secretion of fluids, often causing diarrhea.