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Meatloaf is done when a meat thermometer inserted in its center reads 160 degrees Fahrenheit. Ground beef used for food items like hamburgers or meatloaf should be at this temperature after it is cooked.
A 2.5 pound meatloaf should be cooked for approximately 1.5 hours  in a preheated 350 degree oven. Cook until the inside of the  meatloaf is 170 degrees or until the juices â¦ are no longer pink or  red.