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Causes of sepsis. Sepsis can be triggered by an infection in any part of the body. The most common sites of infection leading to sepsis are the lungs, urinary tract, tummy (abdomen) and pelvis. Sepsis may develop when you're already in hospital. For example, you're more likely to develop sepsis if:
1 Sepsis is when the infection reaches the bloodstream and causes inflammation in the body.  Severe sepsis is when the infection is severe enough to affect the function of your organs, such as the heart, brain, and kidneys.