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Causes of sepsis. Sepsis can be triggered by an infection in any part of the body. The most common sites of infection leading to sepsis are the lungs, urinary tract, tummy (abdomen) and pelvis. Sepsis may develop when you're already in hospital. For example, you're more likely to develop sepsis if:
Sepsis occurs when your body has a strong immune response to the infection. This leads to widespread inflammation throughout the body. Itâs called severe sepsis if it leads to organ failure. People with chronic diseases, such as HIV or cancer, are at a higher risk of sepsis.