A fontanel may be soft and depressed as a result of dehydration. Also spelled fontanelle, fonticulus. Fontanels. fontanel Fontanelle, soft spot Anatomy A membrane-covered region on the skull of a fetus/infant, which corresponds to the convergence of suture lines, where ossification has not yet occurred fontanel
(February 2012) (Learn how and when to remove this template message) Tibial dyschondroplasia (TD) is a metabolic disease of young poultry that affects the growth of bone and cartilage. Often occurs in broilers (chickens raised for meat) and other poultry which have been bred for fast growth rates.
About 80 percent of people with achondroplasia have average-size parents; these cases result from new mutations in the FGFR3 gene. In the remaining cases, people with achondroplasia have inherited an altered FGFR3 gene from one or two affected parents.Individuals who inherit two altered copies of this gene typically have a severe form of achondroplasia that causes extreme shortening of the bones and an underdeveloped rib cage.wo specific mutations in the FGFR3 gene are responsible for almost all cases of achondroplasia. Researchers believe that these mutations cause the FGFR3 protein to be overly active, which interferes with skeletal development and leads to the disturbances in bone growth seen with this disorder.