Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Too much pressure can be from causes such as: 1  footwear that is too tight. 2  toe deformities, such as hammer toes - the top of the hammer toe is an area for increased pressure on the top of the toe. 3  bony prominence.