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DNA is a polar molecule because it has a negatively (-) charged phosphate group attached to the 5' end of the molecule and a negatively charge hydroxl group (OH) attached to t â¦ he 3' prime end of the molecule. Thus, it is a POLAR molecule which allows it to interact in an aqueous environment.NA is a polar molecule because it has a negatively (-) charged phosphate group attached to the 5' end of the molecule and a negatively charge hydroxl group (OH) attached to t â¦ he 3' prime end of the molecule.
In genetics, crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein.DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired.The RAD51 family plays a role in repair. The crosslinking reaction by Psoralens targets TA sequences intercalating in DNA and linking one base of the DNA with the one below it. 2  Psoralen adducts cause replication arrest and is used in the treatment of psoriasis and vitiligo.