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Causes of sepsis. Sepsis can be triggered by an infection in any part of the body. The most common sites of infection leading to sepsis are the lungs, urinary tract, tummy (abdomen) and pelvis. Sepsis may develop when you're already in hospital. For example, you're more likely to develop sepsis if:
Sepsis is caused most commonly by bacteria in the bloodstream, a condition known as bacteremia (bak-tuh-REE-me-uh). These bacteria produce toxins * that provoke a response by the body's immune system. The effect of the toxins combined with the response of the immune system brings about the disease.