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BUT Wellbutrin is also known to increase anxiety in certain patients. It's not an SSRI medication like most anti-depressants prescribed today (SSRIs are serotonin related) such as Paxil, Prozac, Zoloft and other popular SSRIs. Wellbutrin deals with dopamine receptors in our brain.
How Wellbutrin Works. As mentioned above, Wellbutrin affects certain chemicals in the brain (called neurotransmitters) which nerve cells use to transmit messages from one another. It is suggested that depression is caused by an imbalance in these brain chemicals.