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Causes of sepsis. Sepsis can be triggered by an infection in any part of the body. The most common sites of infection leading to sepsis are the lungs, urinary tract, tummy (abdomen) and pelvis. Sepsis may develop when you're already in hospital. For example, you're more likely to develop sepsis if:
Sources of infection. Types of infection associated with sepsis include: 1  lung infection (pneumonia). 2  appendicitis. 3  an infection of the thin layer of tissue that lines the inside of the abdomen (peritonitis). 4  an infection of the bladder, urethra or kidneys (urinary tract infection).