Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Ingrown toenail An ingrown toenail, when the side of the toenail grows into the skin, causes toe redness, pain, and swelling. Bunions A bunion is a bony bump at the base of the big toe and causes redness, numbness, burning and joint pain.