Other signs and symptoms of HIV infection include: 1  genital ulcers. 2  genital warts. 3  severe mucosal herpes infections.
1 Pain, swelling, redness, and warmth that develop suddenly in a big toe joint may be caused by gout. 2  Other conditions or diseases that may cause inflammation include: 3  Arthritis or rheumatic diseases. 4  Retrocalcaneal bursitis and tendinitis, which can occur from overuse injuries.
Big toe pain can sometimes extend from deep inside the joint; at other times it is localized to the nail. Whatever the cause, big toe pain makes it difficult for many people to remain active. The cause of big toe pain is often an underlying condition, such as gout, or a fracture resulting from trauma.