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1 People often experience an upset stomach, diarrhea (possibly bloody), abdominal pain and painful swallowing when using aspartame as a sweetener.  Skin and Allergies. Hives and intense itching, lip or mouth swelling and worsening of asthma all can occur due to aspartame.
Some chemotherapy drugs are more prone to cause diarrhea. Diarrhea is particularly problematic for some drugs which are central to the management of colorectal cancer and cancers of the gastrointestinal tract, including the fluoropyrimidines (5-FU) and irinotecan (CPT-11, CamptosarÂ®). Drugs used to treat other cancers may also cause diarrhea, although to a lesser degree.