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Causes of cardiovascular disease. While cardiovascular disease can refer to different heart or blood vessel problems, the term is often used to mean damage to your heart or blood vessels by atherosclerosis (ath-ur-o-skluh-ROE-sis), a buildup of fatty plaques in your arteries.
Heart diseases can damage the coronary arteries, which provide oxygen-rich blood to the heart muscle. Heart diseases can also impair the functioning or structure of the heart and blood vessels. Coronary artery disease causes most heart attacks and is the most common form of heart disease.eart diseases can damage the coronary arteries, which provide oxygen-rich blood to the heart muscle. Heart diseases can also impair the functioning or structure of the heart and blood vessels. Coronary artery disease causes most heart attacks and is the most common form of heart disease.