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The calculation of minute ventilation is simple: MV=TV*Rf or minute volume is equal to tidal volume (amount of air for one breath, ml) multiplied by the respiratory frequency (number of breaths per minute). This table shows normal minute ventilation (liters of air per minute) in healthy subjects at rest (14 studies).
Patients who are septic or have a se-vere acidosis often require a higher minute-ventilation. Respiratory ratescan be increased, as can tidal volume; however, volumes above 10 mL/kgIBW should not be used due to the risk of inducing ventilator associatedlung injury.