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Losartan can be administered once or twice daily at total daily doses of 25 to 100 mg. If the antihypertensive effect measured at trough using once-aday dosing is inadequate, a twice-a-day regimen at the same total daily dose or an increase in dose may give a more satisfactory response.
The usual recommended initial and maintenance dose is 150 mg once daily. Irbesartan at a dose of 150 mg once daily generally provides a better 24 hour blood pressure control than 75 mg.However, initiation of therapy with 75 mg could be considered, particularly in haemodialysed patients and in the elderly over 75 years.n patients not adequately controlled by irbesartan alone, the addition of a low dose of hydrochlorothiazide (12.5 mg) to irbesartan once daily results in a further placebo-adjusted blood pressure reduction at trough of 7-10/3-6 mm Hg (systolic/diastolic).