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White blood cells known as lymphocytes arise from by mitosis of stem cells in the bone marrow. Some lymphocytes migrate to the thymus and become T cells that circulate in the blood and are associated with the lymph nodes and spleen.
1 Lymphocytes-After neutrophils, lymphocytes are the most common type of white blood cell. 2  These cells are spherical in shape with large nuclei and very little cytoplasm. 3  There are three main types of lymphocytes: T cells, B cells, and natural killer cells.lso called leukocytes, white blood cells play an important role in the immune system by identifying, destroying, and removing pathogens, damaged cells, cancerous cells, and foreign matter from the body. Leukocytes originate from bone marrow stem cells and circulate in blood and lymph fluid.