The most common and severe form of Î±1-antitrypsin deficiency is caused by the Z mutation, a single base substitution (Gul342-Lys) in the Î±1-antitrypsin gene. Misfolding of proteins during synthesis can initiate an ordered polymerization, which leads to aggregation of the protein within the cell.
Main article: List of place names of Native American origin in California. 1  Malibu â from VentureÃ±o <Umalibu>, perhaps reflecting [(hu)maliwu], it (the surf) makes a loud noise all the time over there. 2  Pismo Beach - from Chumash Pismu for tar. 3  Simi Valley â from VentureÃ±o <Simiyi>.
The Native American name controversy is an ongoing discussion about the changing terminology used by indigenous peoples of the Americas to describe themselves, as well as how they prefer to be referred to by others.Preferred terms vary primarily by region and age.uring the latter half of the 20th century and the rise of the Indian rights movement, the United States government responded by proposing the use of the term  Native American , to recognize the primacy of indigenous peoples' tenure in the nation.