MALIGNANCY. Low back pain at night that is not relieved by lying down may be caused by a tumor in the cauda equina (the roots of the spinal nerves controlling sensation in and movement of the legs), or a cancer that has spread to the spine from the prostate, breasts, or lungs. The pain is caused by irritation of a nerve root. 2  Sciatica is an example of radicular pain. 3  Referred. 4  The pain is perceived in the lower back but is caused by inflammation elsewhereâoften in the kidneys or lower abdomen.
While most moles donât turn into melanoma, researchers are unsure why some do. Like basal and squamous cell skin cancer, melanoma can be caused by UV rays. However, some melanomas can appear in body parts not exposed to sunlight. Both types of skin cancer occur when your skin cellsâ DNA has errors (or mutations). According to the Mayo Clinic, these errors cause skin cells to grow uncontrollably and form a mass of cancer cells.
There are three major types of skin cancer: (1) basal cell carcinoma (the most common) and (2) squamous cell carcinoma (the second most common), which originate from skin cells, and (3) melanoma, which originates from the pigment-producing skin cells (melanocytes) but is less common, though more dangerous, than the first two varieties.