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No, vitamin C does not help prevent colds. A meta-analysis[1] of 10,708 participants in various studies showed that the risk ratio of contracting a cold while on vitamin C prophylaxis was 0.97 for the general populace.
4. Vitamin E. This antioxidant vitamin, another immune system booster, wonât do much, if anything, to shorten a cold, but it could keep you from getting one. In one year-long, high-quality study from Tufts University, 451 adults age 65 and older were given either 200 IU of vitamin E each day or a placebo.