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Pathophysiology of COPD. COPD is a complex syndrome comprised of airway inflammation, mucociliary dysfunction and consequent airway structural changes.1. Airway inflammation. COPD is characterized by chronic inflammation of the airways, lung tissue and pulmonary blood vessels as a result of exposure to inhaled irritants such as tobacco smoke.
Chronic obstructive pulmonary disease (COPD) is a general term which includes the conditions chronic bronchitis and emphysema. COPD is the preferred term. 1  Chronic means persistent. 2  Bronchitis is inflammation of the bronchi (the airways of the lungs). 3  Emphysema is damage to the smaller airways and air sacs (alveoli) of the lungs. 4  Pulmonary means 'affecting the lungs'.