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Melanosis coli is dark brown pigmentation of the colon that occurs with the use of laxatives containing anthraquinone, such as senna. It can develop within a few months of use, and it can disappear in a few months if the use of the laxative is discontinued.
melanosis. An abnormal accumulation of melanin pigment in the skin or other tissues. If there is a larger quantity than normal of pigment in the tissues of the eye, the condition is referred to as melanosis bulbi (melanosis oculi) or primary acquired melanosis when on the conjunctival epithelium and limbus. It may extend onto the peripheral cornea.