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About Mitral Valve Prolapse & Regurgitation. A heart murmur that is most pronounced when the stethoscope is positioned at the heart's apex and occurs in the late systolic phase may be caused by mitral valve prolapse. This is also known as floppy valve syndrome. The murmur is normally preceded by a series of clicks.
Overview. The human heart has 4 valves. The mitral valve connects the left atrium (LA) and the left ventricle (LV). The mitral valve opens during diastole to allow the blood flow from the LA to the LV. During ventricular systole, the mitral valve closes and prevents backflow to the LA.he human heart has 4 valves. The mitral valve connects the left atrium (LA) and the left ventricle (LV). The mitral valve opens during diastole to allow the blood flow from the LA to the LV.