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About Mitral Valve Prolapse & Regurgitation. A heart murmur that is most pronounced when the stethoscope is positioned at the heart's apex and occurs in the late systolic phase may be caused by mitral valve prolapse. This is also known as floppy valve syndrome. The murmur is normally preceded by a series of clicks.
The mitral valve (also known as the bicuspid valve or left atrioventricular valve) is a dual-flap (bi-from the Latin, meaning double, and mitral-from the Latin, meaning shaped like a mitre) valve in the heart that lies between the left atrium (LA) and the left ventricle (LV).he closing of the mitral valve and the tricuspid valve constitutes the first heart sound (S1). It is not the valve closure itself which produces the sound but the sudden cessation of blood flow, when the mitral and tricuspid valves close. There are some valvular heart diseases that affect the mitral valve.