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Definition of MAJOR HISTOCOMPATIBILITY COMPLEX. : a group of genes in mammals that code for cell-surface polymorphic glycoprotein molecules which display antigenic peptide fragments for T cell recognition and aid in the ability of the immune system to determine self from nonself. ADVERTISEMENT.edical Definition of MAJOR HISTOCOMPATIBILITY COMPLEX. : a group of genes in mammals that function especially in determining the histocompatibility antigens found on cell surfaces and that in humans comprise the alleles occurring at four loci on the short arm of chromosome 6âabbreviation MHC.
Cell proteins become attached to antigen fragments and transport them to the surface of the cell, where they are presented to the bodies defence mechanisms. These transport molecules are called the Major Histocompatibility Complex (MHC) proteins.Without these, there would be no presentation of internal or external antigens to the T cells. The importance of MHC proteins is that they allow T cells to distinguish self from non-self.In every cell in your body, antigens are constantly broken up and presented to passing T cells. Without this presentation, other aspects of the immune response cannot occur.ithout these, there would be no presentation of internal or external antigens to the T cells. The importance of MHC proteins is that they allow T cells to distinguish self from non-self. In every cell in your body, antigens are constantly broken up and presented to passing T cells.