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Lorraine Day, M.D. What is Mad Cow Disease? Mad Cow Disease is the common term for Bovine Spongiform Encepholopathy (BSE), a progressive neurological disorder of cattle which can be transmitted to other species, including humans. In humans, it is called Creutzfeldt-Jakob Disease, after the two doctors who first described the symptoms of the disease.
What Is Mad Cow Disease and Variant Creutzfeldt-Jakob Disease? Mad cow disease is an infectious disease caused by prions that affect the brains of cattle. Abnormal proteins called prions are found in brain tissue of diseased cattle and appear to be the particle that transmits the infection.