In order to get inside the cell, these molecules must pass through porins, which are protein channels that span the outer membrane. Antimicrobial resistance mechanisms in Pseudomonas aeruginosa Gram-negative bacteria possess proteins called porins in their outer membranes that, when altered, reduce or halt drug absorption.
The Code of Federal Regulations (CFR) is a codification (arrangement of) the general and permanent rules published in the Federal Register by the executive departments and agencies of the Federal Government. e-CFR Updated Daily; Beta Site.
Mandatory Medical Device Reporting: The Medical Device Reporting (MDR) regulation (21 CFR 803) contains mandatory requirements for manufacturers, importers, and device user facilities to report certain device-related adverse events and product problems to the FDA. The regulation specified that reports be filed on FDA Medwatch Form 3500A or an electronic equivalent.