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Melanosis coli is dark brown pigmentation of the colon that occurs with the use of laxatives containing anthraquinone, such as senna. It can develop within a few months of use, and it can disappear in a few months if the use of the laxative is discontinued.
Received 10 October 2013, Accepted 25 November 2013, Available online 16 April 2014. Melanosis coli refers to an abnormal brown or black pigmentation of colonic mucosa caused by the presence of lipofuscin in macrophage within the lamina propria [1] .