The word tire is a short form of attire, from the idea that a wheel with a tire is a dressed wheel. The spelling tyre does not appear until the 1840s when the English began shrink fitting railway car wheels with malleable iron. Nevertheless, traditional publishers continued using tire.
For the meat to be properly cooked the internal temperature should be a minimum of 165Â°, preferably 170Â°, for 5 minutes. Set your thermometer alarm for 165Â°, and when it goes off, remove the meat loaf from the 325Â° oven. Cover and let rest for 10 minutes. The temperature will raise another 5Â° while resting.
Best thing to do is to get a thermometer, once the meatloaf hits 160-165F internally then it should be moist and juicy and cooked.   See my blog for the best turkey meatloaf recipe ever and for amazing and original turkey recipes.  http://www.loveturkeymeat.info.eef should be cooked 145 (med. rare) to 165 (med) for things like meatloaf, you wanna pull the loaf out when it's about 5 degrees below the desired temp.