The names of some man-made satellites are Sputnik 1, Explorer 1, the International Space Station, ORBCOMM FM-107, Gonets-19 and SES-8. In 1957, Russia launched the first man-made satellite called Sputnik 1, and the United States sent Explorer 1 into orbit in 1958.
Many medications have been implicated in pedal edema, especially vasodilators, estrogens, NSAIDs, and calcium channel blockers. Dihydropyridine drugs are more likely than other calcium channel blockers to cause pedal edema.
Nonsteroidal anti-inflammatory drugs (also called NSAIDs) stop cyclooxygenase enzymes (also called COX enzymes) in your body from working. COX enzymes speed up your body's production of hormone-like substances called prostaglandins. Prostaglandins cause the feeling of pain by irritating your nerve endings.