The FDA first approved Invokana as the first SGLT2 drug in March 2013. Since then, it has become a cash cow for J&J and its Janssen Pharmaceuticals unit. In the first quarter of 2015, the drug already brought in $278 million, triple what it made last year.
During contraction, the smooth-muscle cell's intermediate filaments help to draw the cell up, like closing a drawstring purse. Calcium ions regulate contraction in smooth muscle, but they do it in a slightly different way than in skeletal muscle: 1  Calcium ions come from outside of the cell.2  Calcium ions bind to an enzyme complex on myosin, called calmodulin-myosin light chain kinase. Calcium ions come from outside of the cell. 2  Calcium ions bind to an enzyme complex on myosin, called calmodulin-myosin light chain kinase. 3  The enzyme complex breaks up ATP into ADP and transfers the P i directly to myosin. 4  This P i transfer activates myosin.
Although you have more than 600 muscles in your body, there are only three types of muscle: smooth, cardiac and skeletal.Each muscle helps to keep you in motion, your heart beating or signal a natural response in your body, such as the ability to keep your eyes focused.ther examples of smooth muscle include the uterus, the bladder and the muscle behind the eyes that keeps your eyes focused. In terms of appearance, smooth muscles are long, thin-shaped cells attached to bones in the body. Smooth muscles are also found in the blood vessels, helping blood to move around the body.