The FDA first approved Invokana as the first SGLT2 drug in March 2013. Since then, it has become a cash cow for J&J and its Janssen Pharmaceuticals unit. In the first quarter of 2015, the drug already brought in $278 million, triple what it made last year.
During contraction, the smooth-muscle cell's intermediate filaments help to draw the cell up, like closing a drawstring purse. Calcium ions regulate contraction in smooth muscle, but they do it in a slightly different way than in skeletal muscle: 1  Calcium ions come from outside of the cell.2  Calcium ions bind to an enzyme complex on myosin, called calmodulin-myosin light chain kinase. Calcium ions come from outside of the cell. 2  Calcium ions bind to an enzyme complex on myosin, called calmodulin-myosin light chain kinase. 3  The enzyme complex breaks up ATP into ADP and transfers the P i directly to myosin. 4  This P i transfer activates myosin.
Confidence votes 17. Smooth muscle is a type of muscle. Smooth muscle makes up most of the muscle in the organs such as the heart. Unlike skeletal muscle smooth muscles are not under direct voluntary control.Example we can't make are heart beat on by our self. We need a muscle the keeps the heart beating.onfidence votes 17. Smooth muscle is a type of muscle. Smooth muscle makes up most of the muscle in the organs such as the heart. Unlike skeletal muscle smooth muscles are not under direct voluntary control. Example we can't make are heart beat on by our self. We need a muscle the keeps the heart beating.