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Antibiotics can take two to three weeks to leave your system. They seem to work overtime to clean up your system even after you stop taking the pills. Also, some antibiotics work longer or shorter depending on the kind. For instance, Neomycin, is not completely absorbed into the blood system and is excreted out through urine and fecal matter. In this case, it is only in the system for 4-5 days.
Report Abuse. antibiotics take 48 hours to start working, the pain should start easing at this time, they also carry on working for 48 hours after you have finished the course, if you still have pain after this goback to the dentist or dr, you can take pain killers with antibiotics. t_a_i_s_h_a Â· 9 years ago.Thumbs up.0.ntibiotics take 48 hours to start working, the pain should start easing at this time, they also carry on working for 48 hours after you have finished the course, if you still have pain after this goback to the dentist or dr, you can take pain killers with antibiotics. t_a_i_s_h_a Â· 9 years ago. Thumbs up.