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Pathophysiology of COPD. COPD is a complex syndrome comprised of airway inflammation, mucociliary dysfunction and consequent airway structural changes.1. Airway inflammation. COPD is characterized by chronic inflammation of the airways, lung tissue and pulmonary blood vessels as a result of exposure to inhaled irritants such as tobacco smoke.
The variability in how COPD appears in people has led to a classification system that helps define COPD by the level of severity. The current classification of COPD involves four levels of increasing severity and is derived from the Global Initiative on Obstructive Lung Disease (GOLD) guidelines.