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Melanosis coli is dark brown pigmentation of the colon that occurs with the use of laxatives containing anthraquinone, such as senna. It can develop within a few months of use, and it can disappear in a few months if the use of the laxative is discontinued.
Melan-A, isolated as a melanoma-specific antigen, is a transmembrane protein, which is expressed in skin, retina and the majority of cultured melanocytes as well as in melanomas and angiomyolipomas.n immunoprecipitates of Melan-A positive cell lines SK-MEL-13 and SK-MEL-19, the antibody labels a protein doublet of 20-22 kDa corresponding to Melan-A, whereas no precipitation is detected in Melan-A mRNA-negative melanoma cell lines (1). Reagent Provided.