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Alpha-1 antitrypsin deficiency Alpha-1 antitrypsin deficiency is an inherited disorder that may cause lung disease and liver disease. The signs and symptoms of the condition and the age at which they appear vary among individuals.People with alpha-1 antitrypsin deficiency usually develop the first signs and symptoms of lung disease between ages 20 and 50.
Nicotinic acid Deficiency. Disease Agents. Deficiency of the B vitamin niacin (nicotinic acid). Niacin is the vitamin component of two important coenzymes involved in carbohydrate, fat and protein metabolism: nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate.urther Information. 1  Relatively high requirement for niacin in ducklings; ducks are less efficient than chickens at synthesising niacin from tryptophan, probably due to relatively high picolinic carboxylase activity (B13 .46.w1, B32 .2.23).