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About Mitral Valve Prolapse & Regurgitation. A heart murmur that is most pronounced when the stethoscope is positioned at the heart's apex and occurs in the late systolic phase may be caused by mitral valve prolapse. This is also known as floppy valve syndrome. The murmur is normally preceded by a series of clicks.
Mitral Valve Murmurs. The mitral valve is located in the heart between the left ventricle and the left atrium, two of the heart's four chambers. When blood, returning from the lungs where it has been oxygenated, fills the left atrium, the mitral valve opens to allow the blood to flow into the left ventricle.