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Definition of MAJOR HISTOCOMPATIBILITY COMPLEX. : a group of genes in mammals that code for cell-surface polymorphic glycoprotein molecules which display antigenic peptide fragments for T cell recognition and aid in the ability of the immune system to determine self from nonself. ADVERTISEMENT.edical Definition of MAJOR HISTOCOMPATIBILITY COMPLEX. : a group of genes in mammals that function especially in determining the histocompatibility antigens found on cell surfaces and that in humans comprise the alleles occurring at four loci on the short arm of chromosome 6âabbreviation MHC.
The major histocompatibility complex and its functions. The function of MHC molecules is to bind peptide fragments derived from pathogens and display them on the cell surface for recognition by the appropriate T cells.he major histocompatibility complex is located on chromosome 6 in humans and chromosome 17 in the mouse and extends over some 4 centimorgans of DNA, about 4 Ã 10 6 base pairs. In humans it contains more than 200 genes.