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About Mitral Valve Prolapse & Regurgitation. A heart murmur that is most pronounced when the stethoscope is positioned at the heart's apex and occurs in the late systolic phase may be caused by mitral valve prolapse. This is also known as floppy valve syndrome. The murmur is normally preceded by a series of clicks.
The valve located in the left atrium is the mitral valve. As the left atrium fills with the newly oxygenated blood, the mitral valve remains closed. As the pressure changes within the left atrium and left ventricle, the mitral valve opens, allowing the oxygenated blood to flow into the left ventricle.