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No, vitamin C does not help prevent colds. A meta-analysis[1] of 10,708 participants in various studies showed that the risk ratio of contracting a cold while on vitamin C prophylaxis was 0.97 for the general populace.
Available in powdered form, buffered vitamin C contains the nutrient vitamin C mixed with other minerals, such as calcium and magnesium. Taking buffered vitamin C helps avoid digestive trouble that may be caused by the acidity of regular vitamin C supplements. The buffered form of vitamin C is used when mega-dosing, which is taking large doses of vitamin C to combat cancer and other aliments. Large doses of vitamin C may cause headache and fatigue.