Water-level data from multiple-well monitoring sites on both sides of the Calico-Newberry Fault indicate that, as in the Camp Rock-Harper Lake Fault zone, groundwater flow is impeded in both aquifers. Subsurface flow through the Baja subarea is affected by low-permeability deposits present at shallow depths in two locations.
eGFR, estimated glomerular filtration rate. This table applies to creatinine-based and cystatin C-based eGFR. References. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Inter Suppl. 2013;3:1-150.
S1011. Afatinib (BIBW2992). Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt) , EGFR(L858R) , EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM in cell-free assays, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.EE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCÎ± and CDK1.