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Definition of MAJOR HISTOCOMPATIBILITY COMPLEX. : a group of genes in mammals that code for cell-surface polymorphic glycoprotein molecules which display antigenic peptide fragments for T cell recognition and aid in the ability of the immune system to determine self from nonself. ADVERTISEMENT.edical Definition of MAJOR HISTOCOMPATIBILITY COMPLEX. : a group of genes in mammals that function especially in determining the histocompatibility antigens found on cell surfaces and that in humans comprise the alleles occurring at four loci on the short arm of chromosome 6âabbreviation MHC.
Explain the role of the major histocompatibility complex to T cell receptor binding. MHC molecules bind with a fragment of protein antigen within the cell and bring it to the cell surgace allowing a nearby T cell to detect the antigen and bind to it.