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Last week, the American Medical Association voted to classify obesity as a disease. In one day, 78 million American adults and 12 million American children were deemed to have a medical condition that needs treatment.The decision was controversial to say the least.n some ways, cataloging obesity as a disease is a way of conferring legitimacy: it is a condition, not a lapse in willpower; it warrants medical attention; it is worthy of insurance coverage. All of that is positive.
The distinction between monogenic obesity and obesity due to a major gene effect may appear semantic. However, because BMI is a quantitative trait with obesity representing the right tail of the distribution, attempts to address this distinction are warranted.he brain derived neurotrophic factor (BDNF) is involved in weight regulation downstream of the MC4R. Mutations in single genes of the leptinergicâmelanocortinergic pathway have been shown to have a monogenic effect on the development of obesity.