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Melanosis coli is dark brown pigmentation of the colon that occurs with the use of laxatives containing anthraquinone, such as senna. It can develop within a few months of use, and it can disappear in a few months if the use of the laxative is discontinued.
Discussion. Melanosis coli is an abnormal brown or black pigmentation of the colonic mucosa caused by the presence of lipofuscin in macrophage within the lamina propria [1] .This dark pigment is produced by the breakdown of apoptotic colonic epithelial cells [4] .onclusion. As reported in the rest of gastro-intestinal tract, melanosis coli can be observed in patient without history of anthraquinones use. Other causes, such as ingestion of osmotic laxatives or chronic constipation can be involved.