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Alpha-1 antitrypsin deficiency Alpha-1 antitrypsin deficiency is an inherited disorder that may cause lung disease and liver disease. The signs and symptoms of the condition and the age at which they appear vary among individuals.People with alpha-1 antitrypsin deficiency usually develop the first signs and symptoms of lung disease between ages 20 and 50.
ALPHA THALASSEMIA. Alpha thalassemia is the result of deficient or absent synthesis of alpha globin chains, leading to excess beta globin chains. Alpha globin chain production is controlled by two genes on each chromosome 16 (Table 14,5). Deficient production is usually caused by a deletion of one or more of these genes.