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About Mitral Valve Prolapse & Regurgitation. A heart murmur that is most pronounced when the stethoscope is positioned at the heart's apex and occurs in the late systolic phase may be caused by mitral valve prolapse. This is also known as floppy valve syndrome. The murmur is normally preceded by a series of clicks.
  The mitral valve is located between the left atrium (LA) and left ventricle (LV). When oxygenated blood comes from the lungs into the LA, it goes from the LA to the LV (â¦ diastole). When the LV contracts (systole), it pumps the blood from the LV to the aorta for circulation throughout the body.