Causes and symptoms. The most common cause of pyelonephritis is the backward flow (reflux) of infected urine from the bladder to the upper urinary tract. Bacterial infections also may be carried to one or both kidneys through the bloodstream or lymph glands from infection that began in the bladder.
Diastat is generally well-tolerated. The most common side effect reported during research studies was sleepiness. Since it is given after a seizure, it may be hard to tell if sleepiness is due to the seizure or the medicine.
Long-Term Effects of Painkillers. There are a number of unpleasant side effects associated with painkiller abuse. Mild side effects include nausea, vomiting, and diarrhea, usually caused by the way the drug interacts with opioid receptors along the digestive tract.he long-term effects also depend on how the drug is taken. Crushing and injecting the tablet into the bloodstream can cause long-term heart damage and other cardiovascular issues, and can increase the likelihood of a heart attack.