Like the M 1 and M 3 muscarinic receptor, M 5 receptors are coupled with G proteins of class Gq that upregulate phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signaling pathway.
Radioactive iodine is a very effective type of treatment for cancer of the thyroid gland. Thyroid cells absorb iodine. The radioactive iodine from the drink or capsule is absorbed into your body and picked up by the thyroid cancer cells wherever they are. So it can kill the cancer cells even if they have spread.
This is because such therapies rely on oxygen molecules to damage the DNA of cancer cells and blood flow to transport therapeutic drugs to the tumour. In contrast, the NTU team showed that dead C. sporogenes bacteria can kill tumour cells in an oxygen-starved tumour microenvironment.