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You can use most sugar substitutes if you have diabetes, including: 1  Saccharin (Sweet'N Low) 2  Aspartame (NutraSweet, Equal) 3  Acesulfame potassium (Sunett)  Sucralose (Splenda)
They found that saccharin (a.k.a. SweetâN Low), sucralose (a.k.a. Splenda) and aspartame (a.k.a. NutraSweet and Equal) raised blood sugar levels by dramatically changing the makeup of the gut microorganisms, mainly bacteria, that are in the intestines and help with nutrition and the immune system.