In order to get inside the cell, these molecules must pass through porins, which are protein channels that span the outer membrane. Antimicrobial resistance mechanisms in Pseudomonas aeruginosa Gram-negative bacteria possess proteins called porins in their outer membranes that, when altered, reduce or halt drug absorption.
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The Code of Federal Regulations (CFR) is an annual codification of the general and permanent rules published in the Federal Register by the executive departments and agencies of the Federal Government. Writing Resources. Learn how to create effective, understandable documents for publication in the Federal Register.