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Melanosis coli is dark brown pigmentation of the colon that occurs with the use of laxatives containing anthraquinone, such as senna. It can develop within a few months of use, and it can disappear in a few months if the use of the laxative is discontinued.
melanosis. melanosis coÂ´li black or dark brown discoloration of the mucosa of the colon, due to the presence of pigment-laden (not true melanin) macrophages within the lamina propria. neurocutaneous melanosis giant hairy nevus accompanied by malignant melanomas of the meninges.