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Antibiotics can take two to three weeks to leave your system. They seem to work overtime to clean up your system even after you stop taking the pills. Also, some antibiotics work longer or shorter depending on the kind. For instance, Neomycin, is not completely absorbed into the blood system and is excreted out through urine and fecal matter. In this case, it is only in the system for 4-5 days.
How long does it take for antibiotics to kick in. Antibiotics should take effect within 2 to 3 days. Sometimes you will see an improvement as quickly as within 12 hours depending on the type of infection and antibiotic used to treat it. ChaCha! [ Source: http://www.chacha.com/question/how-long-does-it-take-for-antibiotics-to-kick-in ]