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About Mitral Valve Prolapse & Regurgitation. A heart murmur that is most pronounced when the stethoscope is positioned at the heart's apex and occurs in the late systolic phase may be caused by mitral valve prolapse. This is also known as floppy valve syndrome. The murmur is normally preceded by a series of clicks.
In mitral valve disease, the mitral valve, which is located between your left heart chambers (left atrium and left ventricle), doesn't work properly. Types of mitral valve disease include:Mitral valve regurgitation. In this condition, the flaps (leaflets) of the mitral valve don't close tightly, causing blood to leak backward into the left atrium of your heart. If not treated, it can result in heart muscle damage.The most common cause of blood leakage is mitral valve prolapse, in which the leaflets bulge back into the left atrium as your heart contracts. 1  Mitral valve stenosis. 2  In this condition, the flaps of the mitral valve become thick or stiff, and they may fuse together. Mitral valve stenosis. 2  In this condition, the flaps of the mitral valve become thick or stiff, and they may fuse together. 3  This results in a narrowed valve opening and reduced blood flow from the left atrium to the left ventricle.