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About Mitral Valve Prolapse & Regurgitation. A heart murmur that is most pronounced when the stethoscope is positioned at the heart's apex and occurs in the late systolic phase may be caused by mitral valve prolapse. This is also known as floppy valve syndrome. The murmur is normally preceded by a series of clicks.
Then they shut to keep blood from flowing backward. When the heart's valves open and close, they make a lub-DUB sound that a doctor can hear using a stethoscope. 1  The first soundâthe lubâis made by the mitral and tricuspid valves closing at the beginning of systole (SIS-toe-lee). 2  Systole is when the ventricles contract, or squeeze, and pump blood out of the heart.