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Melanosis coli is dark brown pigmentation of the colon that occurs with the use of laxatives containing anthraquinone, such as senna. It can develop within a few months of use, and it can disappear in a few months if the use of the laxative is discontinued.
When this happens, the colon. instead relies on the laxatives to bring on bowel movements. In addition, the ongoing use of laxatives may cause a potassium imbalance in the body, which in. rare cases can become a serious health threat. Treatment Options. No medical treatment is necessary for melanosis coli. Patients are advised to stop taking laxatives, which usually reverses the discoloration of the colon after a fairly short period of time. If constipation â generally defined as the passage of small, hard and dry bowel movements fewer.