The names of some man-made satellites are Sputnik 1, Explorer 1, the International Space Station, ORBCOMM FM-107, Gonets-19 and SES-8. In 1957, Russia launched the first man-made satellite called Sputnik 1, and the United States sent Explorer 1 into orbit in 1958.
Many medications have been implicated in pedal edema, especially vasodilators, estrogens, NSAIDs, and calcium channel blockers. Dihydropyridine drugs are more likely than other calcium channel blockers to cause pedal edema.
This risk may be higher for people who take NSAIDs for a long time. Other major side effects of NSAIDs are gastrointestinal problems. Some 10 to 50 percent of patients are unable to tolerate NSAID treatment because of these side effects, which include abdominal pain, diarrhea, bloating, heartburn, and upset stomach.