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You can use most sugar substitutes if you have diabetes, including: 1  Saccharin (Sweet'N Low) 2  Aspartame (NutraSweet, Equal) 3  Acesulfame potassium (Sunett)  Sucralose (Splenda)
The caffeine doesn't necessarily make the analgesic effects of aspirin more powerful, but it does speed up the relief; caffeine speeds up the heart rate and blood flow, which serves to ferry aspirin throughout the system at a faster rate. Aspirin and caffeine are also combined for use as a weight loss supplement.