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The catalase test is used to differentiate staphylococci (catalase-positive) from streptococci (catalase-negative). The enzyme, catalase, is produced by bacteria that respire using oxygen, and protects them from the toxic by-products of oxygen metabolism.he catalase test is used to differentiate staphylococci (catalase-positive) from streptococci (catalase-negative). The enzyme, catalase, is produced by bacteria that respire using oxygen, and protects them from the toxic by-products of oxygen metabolism.
Negative ANCA tests results mean it is unlikely that a person's symptoms are due to an autoimmune vasculitis. For a positive result on the indirect immunofluorescence microscopy method, several different ANCA patterns may be seen: 1  Perinuclear (pANCA) â most of the fluorescence occurs near the nucleus.ositive ANCA, PR3, and/or MPO tests help to support a diagnosis of systemic autoimmune vasculitis and to distinguish between different types. However, to confirm a diagnosis, a biopsy of an affected site is often required.