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Antibiotics can take two to three weeks to leave your system. They seem to work overtime to clean up your system even after you stop taking the pills. Also, some antibiotics work longer or shorter depending on the kind. For instance, Neomycin, is not completely absorbed into the blood system and is excreted out through urine and fecal matter. In this case, it is only in the system for 4-5 days.
Take all the medication that your doctor has prescribed for the recommended length of time. Because antibiotics tend to work fairly rapidly, you may feel much better after taking only a few days' worth of a prescribed seven-day course of antibiotics. Never stop taking the medication because you feel better.