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Impact upon pH. Both acetoacetic acid and beta-hydroxybutyric acid are acidic, and, if levels of these ketone bodies are too high, the pH of the blood drops, resulting in ketoacidosis, a complication of untreated Type I diabetes, and sometimes in end stage Type II (see diabetic ketoacidosis).
It seems that a similar thing happens with blood ketones (BHB) over a longer period of time. As our blood glucose levels decrease, our ketones increase to make up for the lack of fuel. When we have less glucose available our insulin levels go down, more fat is burned, and blood ketone levels rise. Crowdsourced ketone and glucose values