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Alpha-1 antitrypsin deficiency Alpha-1 antitrypsin deficiency is an inherited disorder that may cause lung disease and liver disease. The signs and symptoms of the condition and the age at which they appear vary among individuals.People with alpha-1 antitrypsin deficiency usually develop the first signs and symptoms of lung disease between ages 20 and 50.
Childhood liver disease Alpha-1 antitrypsin deficiency is the most common genetic or inherited cause of liver disease in infants and children. The first signs are often jaundice, pale stools, excessive bleeding or an enlarged liver-all non-specific signs of liver disease.