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You can use most sugar substitutes if you have diabetes, including: 1  Saccharin (Sweet'N Low) 2  Aspartame (NutraSweet, Equal) 3  Acesulfame potassium (Sunett)  Sucralose (Splenda)
So although youâre not ingesting calories in the form of sugar, aspartame can still raise your insulin and leptin levels. Elevated insulin and leptin levels, in turn, are two of the driving forces behind obesity, diabetes, and a number of our current chronic disease epidemics.