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In addition, evidence on their combined effect on all-cause mortality is conflicting (17, 18). To address the interaction of obesity and OSA, we used a large historical cohort of patients with suspected OSA and investigated whether obesity influences the effect of nocturnal hypoxemia on cardiovascular events.
Complications of Obesity Hypoventilation Syndrome. When left untreated, OHS can cause serious problems, such as: 1  Leg edema, which is swelling in the legs caused by fluid in the body's tissues.  Pulmonary hypertension, which is increased pressure in the pulmonary arteries.