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Melanosis coli is dark brown pigmentation of the colon that occurs with the use of laxatives containing anthraquinone, such as senna. It can develop within a few months of use, and it can disappear in a few months if the use of the laxative is discontinued.
Melanosomes are the granules within melanocytes where melanin is synthesized. In humans, melanin is the primary determinant of skin color and is also found in hair and the iris. The most common form of biological melanin is eumelanin, a brown-black polymer of dihydroxyindole carboxylic acids, and its reduced forms. Most eumelanins are derived from the amino acid tyrosine.