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Definition of MAJOR HISTOCOMPATIBILITY COMPLEX. : a group of genes in mammals that code for cell-surface polymorphic glycoprotein molecules which display antigenic peptide fragments for T cell recognition and aid in the ability of the immune system to determine self from nonself. ADVERTISEMENT.edical Definition of MAJOR HISTOCOMPATIBILITY COMPLEX. : a group of genes in mammals that function especially in determining the histocompatibility antigens found on cell surfaces and that in humans comprise the alleles occurring at four loci on the short arm of chromosome 6âabbreviation MHC.
Abstract. Human major histocompatibility complex (MHC) alleles can be used as markers for a wide variety of autoimmune and other disorders. The interpretation of and possible bases for these associations should be considered in relation to conserved extended MHC haplotypes (CEHs). The genomic architecture of the MHC, strongly influenced by the presence of conserved extended haplotypes (CEHs), which are 1â5 megabase essentially identical by descent common population MHC haplotypes, should be considered when analysing MHC disease markers.