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You can use most sugar substitutes if you have diabetes, including: 1  Saccharin (Sweet'N Low) 2  Aspartame (NutraSweet, Equal) 3  Acesulfame potassium (Sunett)  Sucralose (Splenda)
However, one side effect of some diabetes medications, including insulin, is overshooting the amount of insulin needed by the body to maintain homeostasis, causing blood glucose to go too low (hypoglycemia). Other hormones, all part of the endocrine system, can affect blood glucose levels as well.Cortisol is a steroid hormone that is released under physical or psychological stress; it increases blood glucose levels to provide extra energy.owever, one side effect of some diabetes medications, including insulin, is overshooting the amount of insulin needed by the body to maintain homeostasis, causing blood glucose to go too low (hypoglycemia). Other hormones, all part of the endocrine system, can affect blood glucose levels as well.