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Antibiotics can take two to three weeks to leave your system. They seem to work overtime to clean up your system even after you stop taking the pills. Also, some antibiotics work longer or shorter depending on the kind. For instance, Neomycin, is not completely absorbed into the blood system and is excreted out through urine and fecal matter. In this case, it is only in the system for 4-5 days.
Antibiotics are effective for most UTIs. You should start to feel better within 1 to 2 days after starting antibiotics. If your symptoms get worse or you don't feel better by the third day, call your doctor. It is important to take all of the antibiotics your doctor has prescribed. Most people begin to feel better soon after they begin the medicine. But if you stop taking the medicine as soon as you feel better, the infection may return. When taken as preventive therapy, antibiotics also reduce the number of recurrent UTIs. But studies show that this kind of treatment is short-acting. When you stop taking an antibiotic, you are likely to get another UTI.