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In addition, evidence on their combined effect on all-cause mortality is conflicting (17, 18). To address the interaction of obesity and OSA, we used a large historical cohort of patients with suspected OSA and investigated whether obesity influences the effect of nocturnal hypoxemia on cardiovascular events.
Therefore the most common causes of obesity are overeating and physical inactivity. Ultimately, body weight is the result of genetics, metabolism, environment, behavior, and culture.1  Genetics. 2  A person is more likely to develop obesity if one or both parents are obese.3  Genetics also affect hormones involved in fat regulation. 4  For example, one genetic cause of obesity is leptin deficiency.ltimately, body weight is the result of genetics, metabolism, environment, behavior, and culture. 1  Genetics. 2  A person is more likely to develop obesity if one or both parents are obese. 3  Genetics also affect hormones involved in fat regulation.