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Antibiotics can take two to three weeks to leave your system. They seem to work overtime to clean up your system even after you stop taking the pills. Also, some antibiotics work longer or shorter depending on the kind. For instance, Neomycin, is not completely absorbed into the blood system and is excreted out through urine and fecal matter. In this case, it is only in the system for 4-5 days.
2 doctors agreed: Hours to days: The antibiotic should begin to work - that is, kill bacteria - within hours. By a day or so, symptoms should be improving. Depending on how complicated the infection is and how long your course of antibiotics is for, it should be cleared within 3-14 days. ...Read more.