Analysis of enucleated eyes has demonstrated histological features characteristic of nevi within the edges of malignant melanomas, suggesting that at least some melanomas may evolve from malignant transformation within pre-existing nevi.8 Nevertheless, the risk that a choroidal nevus may turn into a melanoma is generally considered extremely low.
Stages of Sleep. During sleep, we usually pass through five phases of sleep: stages 1, 2, 3, 4, and REM (rapid eye movement) sleep. These stages progress in a cycle from stage 1 to REM sleep, then the cycle starts over again with stage 1. We spend almost 50 percent of our total sleep time in stage 2 sleep, about 20 percent in REM sleep, and the remaining 30 percent in the other stages. Infants, by contrast, spend about half of their sleep time in REM sleep. During stage 1, which is light sleep, we drift in and out of sleep and can be awakened easily. Our eyes move very slowly and muscle activity slows. People awakened from stage 1 sleep often remember fragmented visual images.
Light and Deep Sleep. During sleep, you alternate between cycles of REM (rapid eye movement) and NREM (non-rapid eye movement) that repeat about every 90 minutes. You spend about 75 percent of the night in NREM sleep, which consists of four stages of increasing relaxation. Stage one, or the phase between being awake and asleep, is considered light sleep. Deeper sleep begins in stage two, as your breathing and heart rate become regular and your body temperature drops.