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Alpha-1 antitrypsin deficiency Alpha-1 antitrypsin deficiency is an inherited disorder that may cause lung disease and liver disease. The signs and symptoms of the condition and the age at which they appear vary among individuals.People with alpha-1 antitrypsin deficiency usually develop the first signs and symptoms of lung disease between ages 20 and 50.
Alpha-1 antitrypsin deficiency (Î±1-antitrypsin deficiency, A1AD, or AATD) is a genetic disorder that causes defective production of alpha-1 antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells.[1][2] There are several forms and degrees of deficiency; the form ...