It is a common complication of diabetes. The most common cause is poorly controlled blood sugar over time. Diabetic nerve pain can take years to develop. In the early stages, you may have no signs at all, and then only start to feel a tingling or numbness in your feet. As it progresses, you may also feel the pain in your hands and it is often worse at night.
Lastly, the aging process affects how drugs are excreted (eliminated) from the body. The elderly have a decrease in kidney function and blood flow to the kidneys. Due to this decrease, it is common to decrease the dose of drugs that are eliminated by the kidneys.
Long-term Cannabis Use. Studies have linked the long-term abuse of substances such as alcohol, cocaine and heroin with a decrease in the brainâs overall production and release of dopamine. This is because most drugs cause damage to brain cells that produce dopamine.Cannabis users can breathe easy, however, as cannabinoids are believed to have the opposite effect. Likewise, a study published in 2012 found that long-term cannabis consumption does not result in permanent changes in dopamine levels.hese chemicals are used by the brain to transmit signals. Dopamine can affect mood and attention. But dopamine is not just any neurotransmitter. Dopamine is known as the âfeel goodâ neurotransmitter because of its role in feelings of happiness and pleasure.