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HIV/AIDS in South Africa. HIV/AIDS is perceived to be more prevalent in South Africa than anywhere else worldwide. About 12% of the South African population is affected by HIV/AIDS; excluding children, that percentage rises to 18%.
1 In 9 countries, 10% or more of adults are estimated to be HIV-positive. 2  South Africa has the highest number of people living with HIV in the world (6.8 million). 3  Swaziland has the highest prevalence rate in the world (27.7%).