The FDA first approved Invokana as the first SGLT2 drug in March 2013. Since then, it has become a cash cow for J&J and its Janssen Pharmaceuticals unit. In the first quarter of 2015, the drug already brought in $278 million, triple what it made last year.
During contraction, the smooth-muscle cell's intermediate filaments help to draw the cell up, like closing a drawstring purse. Calcium ions regulate contraction in smooth muscle, but they do it in a slightly different way than in skeletal muscle: 1  Calcium ions come from outside of the cell.2  Calcium ions bind to an enzyme complex on myosin, called calmodulin-myosin light chain kinase. Calcium ions come from outside of the cell. 2  Calcium ions bind to an enzyme complex on myosin, called calmodulin-myosin light chain kinase. 3  The enzyme complex breaks up ATP into ADP and transfers the P i directly to myosin. 4  This P i transfer activates myosin.
Your muscles use calcium to contract and move. Photo Credit Brand X Pictures/Brand X Pictures/Getty Images. Calcium is so important to muscular function that if blood calcium runs low, your body will take the calcium from your bones for use.Of all the minerals, your body contains the most calcium, states the National Institutes of Health Office of Dietary Supplements.our muscles use calcium to contract and move. Photo Credit Brand X Pictures/Brand X Pictures/Getty Images. Calcium is so important to muscular function that if blood calcium runs low, your body will take the calcium from your bones for use.