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HIV/AIDS in South Africa. HIV/AIDS is perceived to be more prevalent in South Africa than anywhere else worldwide. About 12% of the South African population is affected by HIV/AIDS; excluding children, that percentage rises to 18%.
1 Nearly 1 in 10 of the nationâs HIV-positive people lives in California and the state ranks second in the nation in cumulative AIDS cases at nearly 160,000, surpassed only by New York. 2  80% of all HIV/AIDS cases occur among gay or bisexual men.  African-Americans account for nearly 18% of those living with HIV/AIDS.