Interferes with sodium reabsorption at distal tubule, resulting in increased water and sodium excretion and decreased potassium excretion. Increases chloride, sodium, and water excretion by interfering with transport of sodium ions across renal tubular epithelium.
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Note: The following scenario includes selected literature on the subject for the purpose of providing a. clinical practice issue for use when applying EBP models. The following does not include an extensive or. integrated review of the literature on the subject.