In order to get inside the cell, these molecules must pass through porins, which are protein channels that span the outer membrane. Antimicrobial resistance mechanisms in Pseudomonas aeruginosa Gram-negative bacteria possess proteins called porins in their outer membranes that, when altered, reduce or halt drug absorption.
The Code of Federal Regulations (CFR) is a codification (arrangement of) the general and permanent rules published in the Federal Register by the executive departments and agencies of the Federal Government. e-CFR Updated Daily; Beta Site.
The laws require cigarettes to exhibit a greater likelihood of self-extinguishing using the E2187 test from ASTM International. The E2187 standard is cited in U.S. state legislation and is the basis for the fire-safe cigarette law in effect in Canada. It is being considered for legislation in other countries. Canada