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Alpha-1 antitrypsin deficiency Alpha-1 antitrypsin deficiency is an inherited disorder that may cause lung disease and liver disease. The signs and symptoms of the condition and the age at which they appear vary among individuals.People with alpha-1 antitrypsin deficiency usually develop the first signs and symptoms of lung disease between ages 20 and 50.
Symptoms. An early symptom of vitamin A deficiency is night blindness, which is caused by a disorder of the retina. Soon thereafter, the whites (conjunctiva) and corneas of the eyes may become dry and thickâa condition called xerophthalmia.isorders that impair the intestineâs absorption of fats can reduce the absorption of vitamin A and increase the risk of vitamin A deficiency. These disorders include chronic diarrhea, celiac disease, cystic fibrosis, certain pancreatic disorders, and blockage of the bile ducts.