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A , Administration, answered. Changes in hormone levels from menopause affect where women gain weight, usually in the stomach area as opposed to the hips or thighs. The hormonal changes affect only where you gain the weight, not why you gain extra weight. After menopause, weight gain is more likely a result of an inactive lifestyle and eating more calories than you burn. Genetics can also play a role in weight gain as we get older.
Changes in estrogen receptors in the hypothalamus of the brain, a sign of menopause, means it can be harder to lose weight. In turn there is a greater burden on women to eat a healthy diet and exercise more to help their metabolism make up for the loss of estrogen, which helps regulate weight gain and appetite. Interestingly, fat cells produce estrogen, along with other hormones and proteins.