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Psychologically disturbed children who bite and suck their fingers cause thickenings that resemble knuckle pads to occur in the skin in the traumatized areas. Patients with bulimia who use their knuckles or fingers to induce emesis sometimes develop fibrotic papules resembling knuckle pads. [8] Some cases of knuckle pads are familial.
Estrogen, among its other functions is responsible for the moisture retention in the body. Less estrogen causes the skin to dry. Moisture: soaking the nails in water softens the keratin. If you work requires you to have wet hands, it is probably the main cause of your brittle nails. For the same reason, biting nails causes brittle nails. The nails are touched by saliva many times during the day and remain moist most of the time.