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A: Prednisone is a corticosteroid medication which is used to treat various inflammatory conditions including temporary use for relief of allergic reactions. Side effects associated with short term use of prednisone include insomnia, stomach upset, mood changes, increased appetite, and weight gain.
If you abruptly stop taking prednisone or taper off too quickly, you might experience prednisone withdrawal symptoms: 1  Severe fatigue. 2  Weakness. 3  Body aches. 4  Joint pain. gradual reduction in prednisone dosage gives your adrenal glands time to resume their normal function. The amount of time it takes to taper off prednisone depends on the disease being treated, the dose and duration of use, and other medical considerations.