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Because anencephaly is caused by abnormalities of the neural tube, it is classified as a neural tube defect. Because the neural tube fails to close properly, the developing brain and spinal cord are exposed to the amniotic fluid that surrounds the fetus in the womb.
Many doctors feel in cases of stroke ( which account for most causes on medical records), the time it happens would be before 13 weeks gestation and account most neural tube defects on folic acid deficiency. But the fact remains, we have a long road to understand Schizencephaly.