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Psychologically disturbed children who bite and suck their fingers cause thickenings that resemble knuckle pads to occur in the skin in the traumatized areas. Patients with bulimia who use their knuckles or fingers to induce emesis sometimes develop fibrotic papules resembling knuckle pads. [8] Some cases of knuckle pads are familial.
Friction occurs when something rubs against your skin for a prolonged period of time. This happens most commonly on hands and feet. Contact dermatitis can also cause blisters. This is a skin reaction to allergens, like poison ivy, latex, adhesives, or irritants like chemicals or pesticides.