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Psychologically disturbed children who bite and suck their fingers cause thickenings that resemble knuckle pads to occur in the skin in the traumatized areas. Patients with bulimia who use their knuckles or fingers to induce emesis sometimes develop fibrotic papules resembling knuckle pads. [8] Some cases of knuckle pads are familial.
Carpal tunnel syndrome occurs when pressure is placed on the nerve, according to MayoClinic.com This pressure, which is usually due to inflammation, causes numbness in the hands and fingers, pain and weakness of the hand. The cause of carpal tunnel syndrome can be arthritis, diabetes, hormone disorders or repetitive use of the hand and wrist.