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An underactive thyroid gland, a disorder called hypothyroidism, would cause a sensation of lump in the throat. General enlargement, nodules and inflammation in the thyroid gland can be caused by both hypo as well as hyperthyroidism. These nodules can cause a feeling of lump in the throat. Diagnosis usually rests on physical examination, blood tests, a needle biopsy and possibly an ultra sound examination.
Having a lump in your thyroid gland. You can have a lump or swelling in your thyroid gland, called a nodule (NOD-jule). Nodules may have no effect on how the gland works, or can lead to too much thyroid hormone. Most nodules are benign (not cancer), but some can be cancerous.