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Design of Experiments. Design of Experiments (DOE) is a study of the factors that the team has determined are the key process input variables (KPIV's) that are the source of the variation or have an influence on the mean of the output. A DOE (or set of DOE's) will help develop a prediction equation for the process in terms of Y = f(X1,X2,X3,X4,....Xn).
Independent and dependent variables are related to one another. The Independent part is what you, the experimenter, changes or enacts in order to do your experiment. The dependent variable is what changes when the independent variable changes - the dependent variable depends on the outcome of the independent variable.