Postgraduate programs are getting a lot more practical with hands-on learning and job-focused training. By Christopher J. Gearon, Contributor | March 13, 2013, at 8:30 a.m. Focus on Job Skills With a Professional Master's Degree.
PARK2 (OMIM *602544) is the parkin gene that may cause a form of autosomal recessive juvenile Parkinson disease (OMIM 600116) due to a mutation in the parkin protein. This form of genetic mutation may be one of the most common known genetic causes of early-onset Parkinson disease.In one study of patients with onset of Parkinson disease prior to age 40 (10% of all PD patients), 18% had parkin mutations, with 5% homozygous mutations.his form of genetic mutation may be one of the most common known genetic causes of early-onset Parkinson disease. In one study of patients with onset of Parkinson disease prior to age 40 (10% of all PD patients), 18% had parkin mutations, with 5% homozygous mutations.
TEXT. Cloning and Expression. Abbott et al. (1999) cloned and characterized KCNE2, a potassium channel gene encoding MinK-related peptide-1 (MiRP1), a small integral membrane subunit that assembles with the HERG gene product (KCNH2; 152427), a pore-forming protein, to alter its function.2006) identified biallelic digenic mutations: a 178C-T transition in exon 1 of the KCNE2 gene, resulting in a phe60-to-leu (F60L) substitution, and a missense mutation in the SCN5A gene (R1623Q; 600163.0007).