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Full Definition of DIPHTHERIA. : an acute febrile contagious disease typically marked by the formation of a false membrane especially in the throat and caused by a gram-positive bacterium (Corynebacterium diphtheriae) that produces a toxin causing inflammation of the heart and nervous system.
/diphÂ·theÂ·ria/ (dif-thÄrÂ´e-ah) an acute infectious disease caused by Corynebacterium diphtheriae and its toxin, affecting the membranes of the nose, throat, or larynx, and marked by formation of a gray-white pseudomembrane, with fever, pain, and, in the laryngeal form, aphonia and respiratory obstruction.