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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
I am being treated for high blood pressure. I use Dynacirc, Lisinopril, and Toprol. Are there any diuretics available which are not related to Thiazides or Lasix, as I am allergic to sulfa drugs? Patients who report a sulfa allergy are generally referring to a previous reaction to a sulfonamide antibiotic drug. Other sulfonamide drug classes such as diuretics have different chemical structures.