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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
There is a lot of understandable confusion about the difference between sulfa drugs, sulfites, sulfates and sulfur. Many people are allergic to sulfa drugs and sulfites and thus assume that they have to avoid sulfates and sulfur, also.I will explain the difference between these four substances in this article.llergies to sulfa containing drugs are not unusual. Sulfa drugs actually contain a molecule called sulfonamide. Sulfonamides contain Sulfur, Oxygen, Nitrogen, and Hydrogen. The sulfonamide drugs were the first antimicrobial drugs (antibiotics) These molecules plug up the bacteriaâs ability to reproduce.