A number of non-infectious causes can result in diarrhea. These include lactose intolerance, irritable bowel syndrome, non-celiac gluten sensitivity, celiac disease, inflammatory bowel disease, hyperthyroidism, and a number of medications. In most cases, stool cultures to confirm the exact cause are not required.
Most dogs are first bred between the 10th and 14th day after the onset of proestrus. As long as the bitch will accept the male, mating every other day for a total of two or three matings is generally considered sufficient. However, signs of proestrus are not obvious in some bitches.
This can last from 4 to 21 days though the average is 7 days. Many expert say the 9-10th day of heat is the optimum day for breeding. It is during this period of time that you will want to allow mating. Most breeders allow the dogs to mate every other day during this period. Then during the last stage of heat she will be less willing to breed as she is going out of heat. This stage can again last from 4 to 21 days as well but averages 7 days. Each dog is different so some evaluation by the owner is necessary.