Also, be sure to see the Game of Thrones Characters chart, here. Below is a simpler chart focusing only on the four main families. It primarily shows the royal bloodline with all the claimants and possible claimants, including popular fan theories (SPOILERS!). Click it to enlarge.
Other drugs, known as prodrugs, are activated by the action of CYP2D6. This enzyme also metabolizes several endogenous substances, such as hydroxytryptamines, neurosteroids, and both m-tyramine and p-tyramine which CYP2D6 metabolizes into dopamine in the brain and liver.
Most of the caffeine you ingest is metabolized by a CYP450 liver enzyme called âCYP1A2.â This means that the body uses CYP1A2 to âdemethylateâ caffeine molecules, transforming them into other substances, chiefly paraxanthine, which are ultimately excreted in the urine.hen caffeine and another drug are each metabolized by CYP1A2, they compete for the enzyme. As a result, each is said to partially block the âenzymatic metabolismâ of the other, and the speed with which they are excreted from the body decreases.