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An underactive thyroid gland, a disorder called hypothyroidism, would cause a sensation of lump in the throat. General enlargement, nodules and inflammation in the thyroid gland can be caused by both hypo as well as hyperthyroidism. These nodules can cause a feeling of lump in the throat. Diagnosis usually rests on physical examination, blood tests, a needle biopsy and possibly an ultra sound examination.
Thyroid nodules are growths or lumps in the thyroid gland in the front of your neck. This gland controls how your body uses energy. Most thyroid nodules are not cancer and do not cause problems. Many don't even need treatment. Sometimes a thyroid nodule can cause problems. Sometimes a nodule can make too much thyroid hormone. When a nodule makes too much hormone, the rest of the gland is suppressed and doesn't work as hard as usual. Most thyroid nodules are not cancerous.