The Human Immunodeficiency Virus (HIV) is one of the worldâs most confusing and complex viruses. In this series, we will strip away the scientific jargon and provide a straightforward guide to HIV with the Elizabeth Glaser Pediatric AIDS Foundation (EGPAF)âs Director of Basic and Clinical Research Jeffrey Safrit.
In the body, L-citrulline is converted to the amino acid L-arginine, which goes on to make another important substance nitric oxide. And nitric oxide is the secret to hard, firm, healthy erections. Heres how it worksâ¦.
PDE5 inhibitors such as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra) are clinically indicated for the treatment of erectile dysfunction.DE5 inhibitors inhibit the degradation of cGMP by PDE5, increasing bloodflow to the penis during sexual stimulation. This mode of action means that PDE5 inhibitors are ineffective without sexual stimulation.