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Psychologically disturbed children who bite and suck their fingers cause thickenings that resemble knuckle pads to occur in the skin in the traumatized areas. Patients with bulimia who use their knuckles or fingers to induce emesis sometimes develop fibrotic papules resembling knuckle pads. [8] Some cases of knuckle pads are familial.
Knuckle cracking has not been shown to be harmful or beneficial. More specifically, knuckle cracking does not cause arthritis. Joint cracking can result from a negative pressure pulling nitrogen gas temporarily into the joint, such as when knuckles are cracked.. This is not harmful.