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A: Prednisone is a corticosteroid medication which is used to treat various inflammatory conditions including temporary use for relief of allergic reactions. Side effects associated with short term use of prednisone include insomnia, stomach upset, mood changes, increased appetite, and weight gain.
Prednisone/Prednisolone may result in these side effects: 1  Increased drinking and urination. 2  Altered behavior. 3  Inhibited growth in young pets.  Diabetes after prolonged 1  use. Cushingâs disease after prolonged 2  use. Panting. 3  Vomiting. Diarrhea.  Ulceration of the 1  digestive tract. 2  Lethargy. Aggression.  Delayed healing.