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Trypophobia Definition. There are thousands of people who claim they have the Trypophobia (fear of holes in the skin). However, It is not recognized in the American Psychiatric Associationâs Diagnostic and Statistical Manual of Mental Disorders (DSM) or other scientific literature.
Medical conditions and skin problems. Many non-dermatologic disorders affect the condition of the skin. A few disorders that may cause skin signs and symptoms include: 1  Autoimmune disease: A butterfly rash across the face is a tell-tale sign of lupus.2  Lupus may also cause other rashes and mouth sores. 3  Those with lupus tend to be very sun sensitive.edical conditions and skin problems. Many non-dermatologic disorders affect the condition of the skin. A few disorders that may cause skin signs and symptoms include: 1  Autoimmune disease: A butterfly rash across the face is a tell-tale sign of lupus.