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Definition of Epigenetic. Epigenetic: Something that affects a cell, organ or individual without directly affecting its DNA. An epigenetic change may indirectly influence the expression of the genome. See also: Epigenetics. From epi- meaning, in this context, after or beside + genetic.
Epigenomics is the study of the complete set of epigenetic modifications on the genetic material of a cell, known as the epigenome.The field is analogous to genomics and proteomics, which are the study of the genome and proteome of a cell (Russell 2010 p. 217 & 230).Epigenetic modifications are reversible modifications on a cellâs DNA or histones that affect gene expression without altering the DNA sequence (Russell 2010 p. 475).Two of the most characterized epigenetic modifications are DNA methylation and histone modification.Epigenetic modifications play an important role in gene expression and regulation, and are involved in numerous cellular processes such as in differentiation/development and tumorigenesis (Russell 2010 p. 597).wo of the most characterized epigenetic modifications are DNA methylation and histone modification. Epigenetic modifications play an important role in gene expression and regulation, and are involved in numerous cellular processes such as in differentiation/development and tumorigenesis (Russell 2010 p. 597).