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Gonorrhea can be prevented with the use of condoms, having sex with only one person who is uninfected, and by not having sex. Treatment is usually with ceftriaxone by injection and azithromycin by mouth. Resistance has developed to many previously used antibiotics and higher doses of ceftriaxone are occasionally required.
Initial treatment. Gonorrhea is treated with antibiotics. Treatment is recommended for: 1  A person who has a positive gonorrhea test. 2  Anyone who has had sexual contact in the past 60 days with a person diagnosed with gonorrhea, whether or not they have symptoms or used condoms.3  A newborn whose mother has gonorrhea at the time of delivery.o prevent PID, prompt treatment of gonorrhea is important. For more information, see the topic Pelvic Inflammatory Disease (PID) . Disseminated gonococcal infection (DGI) occurs when the gonorrhea infection spreads to sites other than the genitals, such as the joints, skin, heart, or blood.