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Definition of Epigenetic. Epigenetic: Something that affects a cell, organ or individual without directly affecting its DNA. An epigenetic change may indirectly influence the expression of the genome. See also: Epigenetics. From epi- meaning, in this context, after or beside + genetic.
Epigenetics - Medicine. 1  Epigenetics has many and varied potential medical applications. [117] 2  Direct comparisons of identical twins constitute an optimal model for interrogating environmental epigenetics. 3  Dizygotic (fraternal) and monozygotic (identical) twins show evidence of epigenetic influence in humans.