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Trypophobia Definition. There are thousands of people who claim they have the Trypophobia (fear of holes in the skin). However, It is not recognized in the American Psychiatric Associationâs Diagnostic and Statistical Manual of Mental Disorders (DSM) or other scientific literature.
Prion diseases. Microscopic holes are characteristic in prion-affected tissue sections, causing the tissue to develop a spongy architecture. This causes deterioration of that spongy tissue in the brain.