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mirtazapine is a newer antidepressant that exhibits both noradrenergic and serotonergic activity it is at least as effective as the older antidepressants for treating mild to severe depressionsedation is the most common side effectirtazapine is a newer antidepressant that exhibits both noradrenergic and serotonergic activity it is at least as effective as the older antidepressants for treating mild to severe depression
It also enhances serotonin neurotransmission at the 5-HT1 receptor and blocks the histaminergic (H1) and muscarinic receptors. Mirtazapine is not a serotonin or norepinephrine reuptake inhibitor but may increase serotonin and norepinephrine by other mechanisms of action.