Erythema multiforme (EM) is a skin reaction that comes from an infection or another trigger. EM is a type of allergic reaction. In most cases, it occurs in response to an infection. In rare cases, it is caused by certain medicines or body-wide (systemic) illness. Infections that may lead to EM include:
The most common causes of sudden (acute) aortic valve regurgitation include: 1  Endocarditis, which is an infection in the heart. 2  Aortic dissection, which means that the inner layer of the aorta separates from the middle layer. 3  Problems with a replacement (artificial) aortic valve.  Trauma to the heart valve or aorta.
Mitral valve regurgitation cause anemia - Could mitral valve regurgitation cause anemia? Unlikely. If one has mixed mitral valve disease with a heavily calcified mitral valve that is both stenotic and regurgitant, one could imagine marked turbulance of the blood flow across the mitral valve with destruction of rbc's however, this is very unlikely.