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Definition of Epigenetic. Epigenetic: Something that affects a cell, organ or individual without directly affecting its DNA. An epigenetic change may indirectly influence the expression of the genome. See also: Epigenetics. From epi- meaning, in this context, after or beside + genetic.
Robin Holliday defined epigenetics as the study of the mechanisms of temporal and spatial control of gene activity during the development of complex organisms.. Thus epigenetic can be used to describe anything other than DNA sequence that influences the development of an organism.