A number of non-infectious causes can result in diarrhea. These include lactose intolerance, irritable bowel syndrome, non-celiac gluten sensitivity, celiac disease, inflammatory bowel disease, hyperthyroidism, and a number of medications. In most cases, stool cultures to confirm the exact cause are not required.
Most dogs are first bred between the 10th and 14th day after the onset of proestrus. As long as the bitch will accept the male, mating every other day for a total of two or three matings is generally considered sufficient. However, signs of proestrus are not obvious in some bitches.
Some dogs would come into heat earlier than six months and can get pregnant in the first heat although it is advisable to breed the dog when it is about 2 years old or after the dog has gone into the 2nd or 3rd heat. Small breeds mature faster than large breeds.