Filgrastim, sold under the brand name Neupogen among others, is a medication used to treat low blood neutrophils due to a number of causes. This includes when it occurs following chemotherapy, radiation poisoning, HIV/AIDS, or is of unknown cause.
Intravenously administered amiodarone causes heart block or bradycardia in 4.9 percent of patients and hypotension in 16 percent. 2 If these conditions occur, infusion of the drug should be discontinued, or the rate of infusion should be reduced.
Pathophysiology. Amiodarone causes a wide spectrum of effects on the thyroid. Amiodarone inhibits type 1 5'-deiodinase enzyme activity, thereby decreasing the peripheral conversion of T4 to triiodothyronine (T3) and reducing the clearance of both T4 and reverse T3 (rT3).