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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
Thiazide diuretics are one type of diuretic. There are a number of thiazide diuretics-they include bendroflumethiazide, chlortalidone, cyclopenthiazide, indapamide, metolazone, and xipamide. Each comes in a different brand name. Thiazide diuretics are a common treatment for high blood pressure.They are also used to clear fluid from the body in conditions where your body accumulates too much fluid, such as heart failure. (But, a type of diuretic called a loop diuretic is more commonly used to treat heart failure.).hiazide diuretics are one type of diuretic. There are a number of thiazide diuretics-they include bendroflumethiazide, chlortalidone, cyclopenthiazide, indapamide, metolazone, and xipamide. Each comes in a different brand name. Thiazide diuretics are a common treatment for high blood pressure.