Members of the DEWS Definition and Classification. Subcommittee developed a contemporary definition of dry eye disease and a three-. part classification system based on etiology, causative mechanisms and disease. severity.
Metaplasia. Definition: Metaplasia is the reversible replacement of one differentiated cell type with another differentiated cell type. Metaplasia causes precursor cells to change their cell fate, and do not change existing differentiated cells.he most common epithelial metaplasia is columnar to squamous (squamous metaplasia), as occurs in the respiratory tract in response to chronic irritation.
Anaplasia Anaplasia refers to a reversion of differentiation in cells and is characteristic of malignant neoplasms. Sometimes, the term also includes an increased capacity for multiplication. Lack of differentiation is considered a hallmark of aggressive malignancies. The term anaplasia literally means to form backward.