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The synthesis of proteins starts with transcribing the instructions in DNA into mRNA. The mRNA is then carried out of the cell's nucleus into the cytoplasm, specifically into structures called ribosomes. The ribosomes, which contain rRNA, are organelles where protein production occurs. The tRNA transports the amino acids to the ribosomes. The code sequence in mRNA is then translated, and specific proteins are synthesized by stringing amino acids together.
One of these components, the ribosome, provides the basic machinery for the translation process. The major role of the ribosome is to catalyse coupling of amino acids into protein according to the sequence specified by the mRNA. The amino acids are brought to the ribosome by tRNA (transfer RNA) molecules. The nucleotide sequence of the mRNA is composed of four different nucleotides whereas a protein is built up from 20 amino acids. To allow the four nucleotides to specify 20 different amino acids, the nucleotide sequence is interpreted in codons, groups of three nucleotides.