A number of non-infectious causes can result in diarrhea. These include lactose intolerance, irritable bowel syndrome, non-celiac gluten sensitivity, celiac disease, inflammatory bowel disease, hyperthyroidism, and a number of medications. In most cases, stool cultures to confirm the exact cause are not required.
Most dogs are first bred between the 10th and 14th day after the onset of proestrus. As long as the bitch will accept the male, mating every other day for a total of two or three matings is generally considered sufficient. However, signs of proestrus are not obvious in some bitches.
small breed dogs tend to have their first heat around 5 6 months while some giant breed dogs will not start to cycle until they are 18 24 months of age although most dogs are sexually mature by one year of age dogs should not be used for breeding until they are at least 2 years of age