Thienopyridines, a class of oral antiplatelet agents, permanently inhibit P2RY12 signaling, which is sufficient to block platelet activation. F2R, TBXA2R and P2RY1 couple to the Gq-PLC-IP3-Ca2+ pathway, inducing shape change and platelet aggregation.
On April 1, 2001, the Austrian Regulatory Authority for Broadcasting and Telecommunications (RTR) was established under Austrian law.
The internal rate of return (IRR), is a profitability metric used by businesses to determine which projects are likely to yield the greatest return per dollar of capital investment.