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This is the third form of hypersensitivity in the Gell-Coombs classification, called Type III hypersensitivity. Immune complex deposition is a prominent feature of several autoimmune diseases, including systemic lupus erythematosus, cryoglobulinemia, rheumatoid arthritis, scleroderma and SjÃ¶gren's syndrome.
Symptoms develop 3 to 10 hours after the immune complex forms. ASPERGILLOSIS, SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) , GLOMERULONEPHRITIS, polyarteritis and other forms of VASCULITIS, and RHEUMATOID ARTHRITIS are type III hypersensitivity reactions.ymptoms and Diagnostic Path. Symptoms vary with the type and severity of the hypersensitivity reaction. Itching and skin rash or URTICARIA (hives) are common with type I hypersensitivity reactions. Symptoms may involve the airways (allergic asthma) or gastrointestinal tract (food allergies).