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A faulty valve. The main cause of acid reflux disease is a problem with the lower esophageal sphincter (LES) muscle. This muscle, which is the âvalveâ between the stomach and the esophagus, normally closes tightly after food has passed through to the stomach. The LES does not stay closed in people with acid reflux disease. When this happens, acid and stomach contents may back up (reflux) into the esophagus. This acid backup can sometimes cause the painful, burning sensation known as heartburn or other symptoms.
Causes of Acid Indigestion. There are a number of factors which can cause acid indigestion. Some of the more common etiologies/causes of acid indigestion include peptic ulcers and gastroesophageal reflux. Although rare, gastric and pancreatic cancers can sometimes cause acid indigestion. In short, acid indigestion can be caused by disease or ulcer in the digestive tract (NIDDK, 2004).