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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
The most common âsulfur allergyâ is that to a sulfonamide drug. Sulfonamide is a generic name for derivatives of sulfanilamide. (PABA sulfonamide). It usually refers to sulfonamide. antimicrobial agents that include sulfamethoxazole, often. combined with trimethoprim as co-trimoxazole, and.