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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
Thiazide diuretics. These drugs inhibit the sodium-chloride sympoter in the distal convoluted tubule, causing water to be retained in the urine. One example of a drug in this class is hydrochlorothiazide. The main conditions these agents are used to treat include: 1  Hypertension or high blood pressure. 2  Heart failure. 3  Kidney stones.