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Psychologically disturbed children who bite and suck their fingers cause thickenings that resemble knuckle pads to occur in the skin in the traumatized areas. Patients with bulimia who use their knuckles or fingers to induce emesis sometimes develop fibrotic papules resembling knuckle pads. [8] Some cases of knuckle pads are familial.
Numerous medical conditions might cause knuckle swelling, including arthritis, gout, heart or kidney disease and infection. Blunt force trauma, of any kind, to the hand may also produce pain and swelling. Fluid retention caused by various medications may appear as joint or knuckle swelling, and individuals having an adverse reaction to antibiotics may also develop aching joints or swollen knuckles.