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Design of Experiments. Design of Experiments (DOE) is a study of the factors that the team has determined are the key process input variables (KPIV's) that are the source of the variation or have an influence on the mean of the output. A DOE (or set of DOE's) will help develop a prediction equation for the process in terms of Y = f(X1,X2,X3,X4,....Xn).
1 Responding (or Dependent) Variable: This is the variable that changes as a result of the changes in the manipulated variable. 2  In our fertilizer example, the responding variable would be the size of the plants. 3  Controlled Variables (or Controls): These are all the things that you will keep the same in your experiment. Responding (or Dependent) Variable: This is the variable that changes as a result of the changes in the manipulated variable. 2  In our fertilizer example, the responding variable would be the size of the plants. 3  Controlled Variables (or Controls): These are all the things that you will keep the same in your experiment.