Erythema multiforme (EM) is a skin reaction that comes from an infection or another trigger. EM is a type of allergic reaction. In most cases, it occurs in response to an infection. In rare cases, it is caused by certain medicines or body-wide (systemic) illness. Infections that may lead to EM include:
1 Heart attack. A heart attack can damage the area of the heart muscle that supports the mitral valve, affecting the function of the valve. If the damage is extensive enough, a heart attack can cause sudden and severe mitral valve regurgitation.  Abnormality of the heart muscle (cardiomyopathy).
Mitral Valve Regurgitation. The mitral valve is on the left side of the heart. It lets blood flow from the upper to the lower heart chamber. Mitral valve regurgitation is diagnosed when the mitral valve in the heart does not close well, which causes blood to leak back from the left ventricle into the left atrium. Mitral valve regurgitation forces the heart to work harder to pump extra blood out of the heart.