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Equally important and coupled with DNA methylation is DNA demethylation, the removal of a methyl group. The demethylation process is necessary for epigenetic reprogramming of genes and is also directly involved in many important disease mechanisms such as tumor progression.hen a CpG island in the promoter region of a gene is methylated, expression of the gene is repressed (it is turned off). The addition of methyl groups is controlled at several different levels in cells and is carried out by a family of enzymes called DNA methyltransferases (DNMTs).
There is plenty of evidence that demonstrates how epigenetic changes (and not changes in the DNA of a gene) have been passed on to the next generation. For example: 1  Drosophila melanogaster-the fruit fly has white eyes.2  Embryos develop in temperatures of 25 degrees Celsius.here are several epigenetic ways that a gene can be modified, that is having its expression altered without changes to its DNA. Two of the most widely studied are DNA methylation and histone modification. 1) DNA methylation-where methyl groups latch onto parts of a DNA sequence and can switch a gene on or off.