Erythema multiforme (EM) is a skin reaction that comes from an infection or another trigger. EM is a type of allergic reaction. In most cases, it occurs in response to an infection. In rare cases, it is caused by certain medicines or body-wide (systemic) illness. Infections that may lead to EM include:
1 Heart attack. A heart attack can damage the area of the heart muscle that supports the mitral valve, affecting the function of the valve. If the damage is extensive enough, a heart attack can cause sudden and severe mitral valve regurgitation.  Abnormality of the heart muscle (cardiomyopathy).
Aortic valve regurgitation is a condition in which the heart's aortic valve does not close properly. This allows blood to leak backward from the aorta into the left ventricle. The condition can be caused by several things, and over time may lead to symptoms such as chest pain, shortness of breath, heart failure, and fainting.