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Definition of Epigenetic. Epigenetic: Something that affects a cell, organ or individual without directly affecting its DNA. An epigenetic change may indirectly influence the expression of the genome. See also: Epigenetics. From epi- meaning, in this context, after or beside + genetic.
But a burgeoning field known as epigenetics is showing that many cancers may not be caused by mutations in genes, but by chemical modifications that alter how the genes function. Such modifications to genes are epigenetic-literally on top of or related to changes in the DNA sequence.