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Thiazide Diuretics. Mechanism of Action: DIURETIC: Thiazides are sulfonamide related organic acids that are secreted into the proximal tubule by an organic secretory mechanism. (Thiazides compete for the same secretory process by which uric acid is secreted into the proximal tubule).
Structural similarity between sulfonamide (left) and PABA (center) is the basis for the inhibitory activity of sulfa drugs on dihydrofolate (right) biosynthesis. A Sulfonamide (or sulphonamide) is a kind of drug. It is a man-made antibiotic. Their ability to kill infectious bacteria is their main function, but some types have other medical uses. For example, sulfasalazine, in addition to its use as an antibiotic, is also used in the treatment of inflammatory bowel disease. Sulfonamides (sometimes called sulfa drugs or sulpha drugs) contain the sulfonamide chemical group.