Similar results have been found in other studies [17] [18]. Based on these reports we have defined hard-to-heal ulcers in this study as venous leg ulcers with an initial area of 10cm2 or greater and a duration of six months or more.
A gene is a segment of DNA containing the code used to synthesize a protein. A chromosome contains hundreds to thousands of genes. Every human cell contains 23 pairs of chromosomes, for a total of 46 chromosomes. A trait is any gene-determined characteristic and is often determined by more than one gene. Some traits are caused by abnormal genes that are inherited or that are the result of a new mutation.
These tiny structures are found inside the cell nucleus and consist of DNA and proteins. There are 46 human chromosomes inside most cells. 44 are autosomes, that is non-sex chromosomes and two are the sex chromosomes - X and Y. The chromosomes are all of different sizes and contain varying number of genes. The structure of human chromosomes change during the life cycle of the cell as it grows and divides.