Filgrastim, sold under the brand name Neupogen among others, is a medication used to treat low blood neutrophils due to a number of causes. This includes when it occurs following chemotherapy, radiation poisoning, HIV/AIDS, or is of unknown cause.
Bradycardia and heart block occur in 1 to 3 percent of patients receiving amiodarone. 2 Amiodarone-induced proarrhythmia occurs at an annual rate of less than 1 percent.
Pathophysiology. Amiodarone causes a wide spectrum of effects on the thyroid. Amiodarone inhibits type 1 5'-deiodinase enzyme activity, thereby decreasing the peripheral conversion of T4 to triiodothyronine (T3) and reducing the clearance of both T4 and reverse T3 (rT3).