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An underactive thyroid gland, a disorder called hypothyroidism, would cause a sensation of lump in the throat. General enlargement, nodules and inflammation in the thyroid gland can be caused by both hypo as well as hyperthyroidism. These nodules can cause a feeling of lump in the throat. Diagnosis usually rests on physical examination, blood tests, a needle biopsy and possibly an ultra sound examination.
Thyroid nodules are very common. A nodule is a swelling or lump, which can be a solid or liquid filled cyst or mass. Most are benign, but a small percentage can be cancerous. So you should always have a nodule evaluated by your physician as soon as you notice it. Symptoms of a nodule can be varied. Some people have hyperthyroidism symptoms -- such as palpitations, insomnia, weight loss, anxiety, and tremors -- and others have hypothyroidism symptoms -- weight gain, fatigue, depression. Some will cycle back and forth between hyperthyroid and hypothyroid symptoms.