Erythema multiforme (EM) is a skin reaction that comes from an infection or another trigger. EM is a type of allergic reaction. In most cases, it occurs in response to an infection. In rare cases, it is caused by certain medicines or body-wide (systemic) illness. Infections that may lead to EM include:
1 Heart attack. A heart attack can damage the area of the heart muscle that supports the mitral valve, affecting the function of the valve. If the damage is extensive enough, a heart attack can cause sudden and severe mitral valve regurgitation.  Abnormality of the heart muscle (cardiomyopathy).
Aortic valve regurgitation is a problem with the aortic valve. The aortic valve allows blood to flow from the heart 's lower left chamber (ventricle) into the aorta and to the body.When the heart rests between beats, the valve closes to keep blood from flowing backward into the heart. When you have aortic valve regurgitation, the aortic valve doesn't close as it should.he most common causes of sudden (acute) aortic valve regurgitation include: 1  Endocarditis, which is an infection in the heart. 2  Aortic dissection, which means that the inner layer of the aorta separates from the middle layer. 3  Problems with a replacement (artificial) aortic valve.