Also, be sure to see the Game of Thrones Characters chart, here. Below is a simpler chart focusing only on the four main families. It primarily shows the royal bloodline with all the claimants and possible claimants, including popular fan theories (SPOILERS!). Click it to enlarge.
Other drugs, known as prodrugs, are activated by the action of CYP2D6. This enzyme also metabolizes several endogenous substances, such as hydroxytryptamines, neurosteroids, and both m-tyramine and p-tyramine which CYP2D6 metabolizes into dopamine in the brain and liver.
A study involving six health males was conducted, and the results show that tofacitinib is primarily metabolized in the liver by cytochrome P450 (70%), and thus inhibitors of cytochrome P450 such as, anticonvulsants, anti-depressants, and proton pump inhibitors will increase the serum concentration of tofacitinib.