Filgrastim, sold under the brand name Neupogen among others, is a medication used to treat low blood neutrophils due to a number of causes. This includes when it occurs following chemotherapy, radiation poisoning, HIV/AIDS, or is of unknown cause.
Bradycardia and heart block occur in 1 to 3 percent of patients receiving amiodarone. 2 Amiodarone-induced proarrhythmia occurs at an annual rate of less than 1 percent.
Beta blockers, like Metoprolol, can cause depression of myocardial contractility and may precipitate heart failure and cardiogenic shock. If signs or symptoms of heart failure develop, treat the patient according to recommended guidelines. It may be necessary to lower the dose of Metoprolol or to discontinue it.