Erythema multiforme (EM) is a skin reaction that comes from an infection or another trigger. EM is a type of allergic reaction. In most cases, it occurs in response to an infection. In rare cases, it is caused by certain medicines or body-wide (systemic) illness. Infections that may lead to EM include:
1 Heart attack. A heart attack can damage the area of the heart muscle that supports the mitral valve, affecting the function of the valve. If the damage is extensive enough, a heart attack can cause sudden and severe mitral valve regurgitation.  Abnormality of the heart muscle (cardiomyopathy).
Causes. Tricuspid valve regurgitation can have several causes. Tricuspid valve regurgitation is usually caused by the lower right heart chamber (right ventricle) bulging (dilating), which can lead to the tricuspid valve not working properly.ou may be diagnosed with this condition when having tests for other conditions. Signs and symptoms of tricuspid valve regurgitation may include: 1  Fatigue. 2  Declining exercise capacity. 3  Swelling in your abdomen, legs or veins in your neck. 4  Abnormal heart rhythms. 5  Pulsing in your neck.