A slight chance of showers between 9pm and 3am, then a chance of showers and thunderstorms after 3am. Some of the storms could produce heavy rain. Cloudy, with a low around 58. East wind around 8 mph. Chance of precipitation is 50%.
As per ACCF/AHA guidelines, a loading dose to initiate digoxin therapy in patients with heart failure is not necessary. 0.125-0.25 mg PO/IV qDay; higher doses including 0.375-0.5 mg/day rarely needed. Use lower end of dosing (0.125 mg/day) in patients with impaired renal function or low lean body mass.
Additional doses of 125 to 375 mcg (0.125 to 0.375 mg) may be given cautiously at 6- to 8- hour intervals until clinical evidence of an adequate effect is noted. The usual amount of digoxin tablets that a 70-kg patient requires to achieve 8 to 12 mcg/kg peak body stores is 750 to 1,250 mcg (0.75 to 1.25 mg).herapy is generally initiated at a dose of 250 mcg (0.25 mg) once daily in patients under age 70 with good renal function, at a dose of 125 mcg (0.125 mg) once daily in patients over age 70 or with impaired renal function, and at a dose of 62.5 mcg (0.0625 mg) in patients with marked renal impairment.