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Vitamin B 12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders.The role of B 12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored.itamin B 12 deficiency, therefore, can lead to increased levels of serum methylmalonic acid. In the second reaction, homocysteine is converted to methionine by using vitamin B 12 and folic acid as cofactors. In this reaction, a deficiency of vitamin B 12 or folic acid may lead to increased homocysteine levels.
Pernicious anaemia is the most common cause of vitamin B12 deficiency in the UK, although accurate figures for how many people have the condition are hard to come by. Doctors do not know why some people produce the antibodies that destroy the stomach parietal cells.ernicious anaemia is a condition in which the body's immune system attacks stomach cells that produce a protein vital for the absorption of vitamin B12. Vitamin B12, which is found naturally in meat, fish and dairy products, is absorbed into the body through the stomach.