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Subcutaneous emphysema can be caused by medical procedures and medical conditions that cause the pressure in the alveoli of the lung to be higher than that in the tissues outside of them. Its most common causes are pneumothorax and a chest tube that has become occluded by a blood clot or fibrinous material.
A discontinuity of the tracheal mucosa is a common cause, either by way of laceration or ulceration. Extension from a pulmonary lesion is also common. The syndrome resulting depends on the location of the air. See also pulmonary emphysema and subcutaneous emphysema (below).