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Vitamin B 12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders.The role of B 12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored.itamin B 12 deficiency, therefore, can lead to increased levels of serum methylmalonic acid. In the second reaction, homocysteine is converted to methionine by using vitamin B 12 and folic acid as cofactors. In this reaction, a deficiency of vitamin B 12 or folic acid may lead to increased homocysteine levels.
Knowledge center. Vitamin B12 is vital for the formation of red blood cells, as well as for the proper functioning and health of nerve tissue. If left untreated, vitamin B12 deficiency, also known as B12 deficiency, can lead to anemia, as well as nerve and brain damage, which may eventually become irreversible.People with B12 deficiency may eventually develop pernicious anemia, a type of blood disorder.f left untreated, vitamin B12 deficiency, also known as B12 deficiency, can lead to anemia, as well as nerve and brain damage, which may eventually become irreversible. People with B12 deficiency may eventually develop pernicious anemia, a type of blood disorder.