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There are many combinations of MTHFR: 1  Homozygous: means you have both copies of either the 677 mutation, or the 1298 mutation, one from from each parent. 2  Heterozygous: means you have one copy of either the 677 mutation, or the 1298 mutation, plus a normal one from the other parent.ore than one mutation of the MTHFR gene. Genes are passed down by your mother and your father. Most literature states there are a good 40-50 different mutations of this important gene which could be passed down by one, or both or your parents.
Dr. Ben Lynch, who is considered one of the foremost experts in the field of MTHFR genetic mutations, has a more complete list here. (See the third paragraph for a link to additional supporting research.) Are all MTHFR mutations the same? No. There are over fifty types of MTHFR gene mutations . . . possibly more that have yet to be discovered. However, the two that are most commonly studied and tested for are C677T and A1298C. Letâs look at the C677T mutation for a moment.