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These include IFIs in patients with AML, which are often presumed or probable fungal infections that are treated empirically, and in high-risk AML patients with prolonged severe neutropenia, antifungal treatment may be started preemptively.
With the recent approval of apixaban in most major countries for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (AF), all 3 of the new oral anticoagulants will now be available for this indication, leaving doctors with the dilemma of which one to use in which patients.