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Vitamin B 12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders.The role of B 12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored.itamin B 12 deficiency, therefore, can lead to increased levels of serum methylmalonic acid. In the second reaction, homocysteine is converted to methionine by using vitamin B 12 and folic acid as cofactors. In this reaction, a deficiency of vitamin B 12 or folic acid may lead to increased homocysteine levels.
Vitamin B12, also known as methylcobalamin or cyanocobalamin, is an indispensable nutrient commonly found in a variety of non-plant based foods, such as fish, shellfish, meat, eggs, and dairy products.Because animal products provide optimum food sources for vitamin B12, vegans have the greatest risk for deficiency.Vegetarians who eat eggs and milk products are also at risk because, on average, they consume less than half of the adult Recommended Dietary Allowance (RDA) of vitamin B12.race amounts of vitamin B12 can be found within tempeh, seaweeds and organic plants in specific geographic regions. ** But unless and until these foods are shown consistently to correct vitamin B12 deficiency, vegans should not rely on them as a vitamin B12 source.