The calf muscles are what are called slow twitch muscles which means that the calf muscles are, for the most part, made up of slow-twitch muscle fibers, fibers that are best at endurance feats. The gastrocnemius and the soleus run between the knee and the ankle.
Therefore the most common causes of obesity are overeating and physical inactivity. Ultimately, body weight is the result of genetics, metabolism, environment, behavior, and culture. 1  Genetics. 2  A person is more likely to develop obesity if one or both parents are obese. 3  Genetics also affect hormones involved in fat regulation. 4  For example, one genetic cause of obesity is leptin deficiency.
Obesity is likely to cause insulin resistance that is linked to anovulation or failure of a woman to produce the egg from each ovary each month. Insulin levels and obesity also lead to altered sex hormones, high androgens (male hormones), high levels of free growth factor 1 etc.