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Updated October 22, 2015. Rheumatoid arthritis is a chronic, autoimmune, inflammatory, potentially disabling type of arthritis which affects 1.5 million American adults. The disease can be associated with joint pain, joint deformity, decreased physical function, as well as systemic effects.
Background. Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unknown cause. The hallmark feature of this condition is persistent symmetric polyarthritis (synovitis) that affects the hands and feet, though any joint lined by a synovial membrane may be involved.he major difference between RA and other forms of inflammatory arthritis, such as psoriatic arthritis, lies not in their respective cytokine patterns but, rather, in the highly destructive potential of the RA synovial membrane and in the local and systemic autoimmunity.