Acetaminophen (Tylenol) liver damage facts. 1  Acetaminophen is a very safe drug when taken as directed, even for people with liver disease. 2  Liver damage from acetaminophen, which can be severe, can result either from an overdose or from regular doses that are taken while drinking alcohol. Most cases of acetaminophen-induced liver injury are caused by an intentional or suicidal overdose.
Pioglitazone is an oral diabetes medicine that helps control blood sugar levels. Pioglitazone is for people with type 2 diabetes. Pioglitazone is sometimes used in combination with insulin or other medications, but it is not for treating type 1 diabetes.
Pioglitazone drugs are sold as a single-ingredient product under the brand name Actos and are also sold in combination with metformin as Actoplus Met (pioglitazone/metformin), Actoplus Met XR (pioglitazone/metformin extended-release), and DueTact (pioglitazone/glimepiride). 1  The complete Actos portfolio of drugs includes the following: 1  ActoPlus Met (active ingredient: metformin hydrochloride; pioglitazone hydrochloride) 2  ActoPlus Met XR (active ingredient: metformin hydrochloride; pioglitazone hydrochloride extended release) 3  Actos (active ingredient: pioglitazone hydrochloride)