Acetaminophen (Tylenol) liver damage facts. 1  Acetaminophen is a very safe drug when taken as directed, even for people with liver disease. 2  Liver damage from acetaminophen, which can be severe, can result either from an overdose or from regular doses that are taken while drinking alcohol. Most cases of acetaminophen-induced liver injury are caused by an intentional or suicidal overdose.
Pioglitazone is an oral diabetes medicine that helps control blood sugar levels. Pioglitazone is for people with type 2 diabetes. Pioglitazone is sometimes used in combination with insulin or other medications, but it is not for treating type 1 diabetes.
Thiazolidinediones, including ACTOS, cause or exacerbate congestive heart failure in some patients [see WARNINGS AND PRECAUTIONS]. After initiation of ACTOS, and after dose increases, monitor patients carefully for signs and symptoms of heart failure (e.g., excessive, rapid weight gain, dyspnea, and/or edema).