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Vitamin B 12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders.The role of B 12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored.itamin B 12 deficiency, therefore, can lead to increased levels of serum methylmalonic acid. In the second reaction, homocysteine is converted to methionine by using vitamin B 12 and folic acid as cofactors. In this reaction, a deficiency of vitamin B 12 or folic acid may lead to increased homocysteine levels.
Share. Vitamin B12, also known as cyanocobalamin, is an essential nutrient in the family complex of the eight B vitamins. Food is the primary source for this nutrient, with supplements being the secondary source for some people.Vitamin B12 is structurally the largest and most complex of all the vitamins known to man.hare. Vitamin B12, also known as cyanocobalamin, is an essential nutrient in the family complex of the eight B vitamins. Food is the primary source for this nutrient, with supplements being the secondary source for some people. Vitamin B12 is structurally the largest and most complex of all the vitamins known to man.