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There are many combinations of MTHFR: 1  Homozygous: means you have both copies of either the 677 mutation, or the 1298 mutation, one from from each parent. 2  Heterozygous: means you have one copy of either the 677 mutation, or the 1298 mutation, plus a normal one from the other parent.ore than one mutation of the MTHFR gene. Genes are passed down by your mother and your father. Most literature states there are a good 40-50 different mutations of this important gene which could be passed down by one, or both or your parents.
MTHFR and 23andMe â Two Peas in a Pod. Click Here to sign Up for 23andMe & get your genome sequenced for just $99. Sign Up for PureGenomics by reading below (free). MTHFR is the tip of the iceberg in relation to your methylation abilities.Knowledge regarding the MTHFR mutation is changing rapidly.I recently attended the Annual Conference of the Institute of Functional Medicine where I heard from methylation experts and researchers.he MTHFR mutation has stirred up a national âcrazeâ about methylation, and the MTHFR Mutation itself has reached Celebrity Status. If anyone knows one single gene mutation (or SNP) in the entire human genome, it is likely to be the MTHFR mutation.