(Redirected from Opportunistic infections) An opportunistic infection is an infection caused by pathogens (bacteria, viruses, fungi, or protozoa) that take advantage of an opportunity not normally available, such as a host with a weakened immune system, an altered microbiota (such as a disrupted gut flora), or breached integumentary barriers.
If someone is described as being 'rough around the edges' it means they are generally good but have a few faults on the outside. Rough around the edges has many meanings: Worn out; Not polished or refined; Not great but not bad either; ans Unkempt.
1 adj If your face or skin is weather-beaten, it is rough with deep lines because you have spent a lot of time outside in bad weather. usu ADJ n (=weathered) ...a stout man with a ruddy, weather-beaten face. 2 adj Something that is weather-beaten is rough and slightly damaged after being outside for a long time.