It felt wintry cold that day. 5 verb If you feel an object, you touch it deliberately with your hand, so that you learn what it is like, for example what shape it is or whether it is rough or smooth. The doctor felt his head... When dry, feel the surface and it will no longer be smooth...
We studied daratumumab, a CD38-targeting, human IgG1Îº monoclonal antibody, in a phase 1â2 trial involving patients with relapsed myeloma or relapsed myeloma that was refractory to two or more prior lines of therapy.e studied daratumumab, a CD38-targeting, human IgG1Îº monoclonal antibody, in a phase 1â2 trial involving patients with relapsed myeloma or relapsed myeloma that was refractory to two or more prior lines of therapy.
Similarly to the strategy with ibrutinib, J&J will try to get daratumumab approved as monotherapy in last line patients. Daratumumabâs remarkable efficacy (discussed here), its breakthrough designation and recent experience with other myeloma drugs (e.g. Kyprolis) make such a strategy an obvious choice.lthough daratumumab is the only CD38 antibody with published clinical results, the 2 other programs have been in phase I long enough to generate an efficacy signal (SAR650984 and MOR202 started phase I in 2010 and 2011, respectively).