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Subcutaneous emphysema can be caused by medical procedures and medical conditions that cause the pressure in the alveoli of the lung to be higher than that in the tissues outside of them. Its most common causes are pneumothorax and a chest tube that has become occluded by a blood clot or fibrinous material.
Cigarette smoking is the most common irritant that causes emphysema. Pipe, cigar, and other types of tobacco smoking can also cause emphysema, especially if the smoke is inhaled. Fumes and Dust. Breathing in other fumes and dusts over a long period of time may also cause the disease.