(Redirected from Opportunistic infections) An opportunistic infection is an infection caused by pathogens (bacteria, viruses, fungi, or protozoa) that take advantage of an opportunity not normally available, such as a host with a weakened immune system, an altered microbiota (such as a disrupted gut flora), or breached integumentary barriers.
If someone is described as being 'rough around the edges' it means they are generally good but have a few faults on the outside. Rough around the edges has many meanings: Worn out; Not polished or refined; Not great but not bad either; ans Unkempt.
Pain along the inner side of the ankle may represent a more serious injury to the tendons or to the ligaments that support the arch and should always be evaluated by a doctor. You're most likely to sprain your ankle when you have your toes on the ground and heel up (plantar flexion).