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There are many combinations of MTHFR: 1  Homozygous: means you have both copies of either the 677 mutation, or the 1298 mutation, one from from each parent. 2  Heterozygous: means you have one copy of either the 677 mutation, or the 1298 mutation, plus a normal one from the other parent.ore than one mutation of the MTHFR gene. Genes are passed down by your mother and your father. Most literature states there are a good 40-50 different mutations of this important gene which could be passed down by one, or both or your parents.
1 Patients with homozygous or combined heterozygous status of MTHFR C677T and A1298C mutation had a higher frequency of DVT after elective THA (odds ratio, 2.86; 95% confidence interval, 1.32-6.35) than those with wild-type. The MTHFR C677T mutation is not a genetic risk factor for URPL except in a Chinese population. 2  Some differences were observed among cases and controls in the prevalence of MTHFR C677T (decrease in mutant allele carriership in UC), these did not explain an excess risk of thrombosis.