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Aldosterone, like ADH also acts on the distant tubules, but also at the kidneyâs collecting ducts. Water retention with the aid of aldosterone is more complex because it has to undergo the Sodium-Potassium exchange channels. In this set-up, potassium is excreted while sodium is retained.
Aldosterone is part of the reninâangiotensin system. Drugs that interfere with the secretion or action of aldosterone are in use as antihypertensives, like lisinopril, which lowers blood pressure by blocking the angiotensin-converting enzyme (ACE), leading to lower aldosterone secretion. (The increased potassium level works to regulate aldosterone synthesis by depolarizing the cells in the zona glomerulosa, which opens the voltage-dependent calcium channels .) The level of angiotensin II is regulated by angiotensin I, which is in turn regulated by renin, a hormone secreted in the kidneys.