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In cardiology, the QT interval is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle. The QT interval represents electrical depolarization and repolarization of the ventricles. A lengthened QT interval is a marker for the potential of ventricular tachyarrhythmias like torsades de pointes and a risk factor for sudden death.
LQTS is caused by mutations in genes that regulate the electrical activity in the heart. People with LQTS may experience palpitations, syncope (fainting), or even sudden death. The name of the condition is based on the EKG pattern present in the majority of individuals with the condition. The QT interval on an EKG represents the time when the heart is relaxing after each heart beat. This interval can be longer than normal in people with LQTS. When the QT interval is prolonged, there is an increased risk for a dangerous heart rhythm.