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Subcutaneous emphysema can be caused by medical procedures and medical conditions that cause the pressure in the alveoli of the lung to be higher than that in the tissues outside of them. Its most common causes are pneumothorax and a chest tube that has become occluded by a blood clot or fibrinous material.
The main cause of emphysema is smoking. The tiny air sacs or alveoli at the bottom of the lungs, which cover a huge lung area, are surrounded by tiny blood vessels. Here, as the oxygen reaches the alveoli, it is absorbed by the blood vessels and then transferred into the bloodstream and to the rest of the body.