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Usually, receptors are proteins found on or within the membrane. Many different types of molecules can bind to receptors on the cell surface, including hormones. An insulin receptor is an example of a receptor that binds to a hormones, specifically insulin.
Insulin-like growth factor binding proteins bind IGF-I and IGF-II with high affinity but do not bind insulin. Of the 6 distinct IGF binding proteins structurally characterized at this time, IGFBP-3 has been shown to be the major carrier of the IGFs, transporting approximately 95% of circulating IGF-I and IGF-II. IGFBP-3 is growth hormone (GH) responsive.