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FLCL was directed by Kazuya Tsurumaki (who previously worked on several animes like Neon Genesis Evangelion) and was produced by Gainax, Production I.G and Starchild Records, who joined together to create the FLCL Production Committee.
Flo, an upbeat store employee for Progressive Corporation, was created by the Boston-based agency Arnold Worldwide, specifically copywriter John Park and art director Steve Reepmeyer. Some have noticed that FLO has some resemblance in style and appearance to Chrissy Hynde of the Pretenders, especially when she sings, Stand by You- one of Chrissy's songs.