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Noun. 1. induration-any pathological hardening or thickening of tissue. sclerosis. disseminated multiple sclerosis, disseminated sclerosis, MS, multiple sclerosis-a chronic progressive nervous disorder involving loss of myelin sheath around certain nerve fibers.
Intestinal neuronal dysplasia (IND) is a disorder of the enteric nervous system that was first described by Meier-Ruge in 1971.ND may be associated with Hirschsprung's disease or may occur as an isolated disorder. The incidence of isolated IND varies from 0.3% to 40% of suction rectal biopsies. The uncertainty regarding the incidence of IND has resulted from considerable confusion concerning essential diagnostic criteria.