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Vitamin B 12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders.The role of B 12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored.itamin B 12 deficiency, therefore, can lead to increased levels of serum methylmalonic acid. In the second reaction, homocysteine is converted to methionine by using vitamin B 12 and folic acid as cofactors. In this reaction, a deficiency of vitamin B 12 or folic acid may lead to increased homocysteine levels.
Vitamin B12 deficiency is a condition in which the body has inadequate stores of vitamin B12. This vitamin is essential for many aspects of health, including the production of red blood cells.Healthy numbers of red blood cells are critical for delivering oxygen and nutrients to the bodyâs cells and tissues.itamin B12 deficiency is most common in people who have a disease or condition in which the body is unable to absorb vitamin B12 from ingested foods. It is also relatively common in older adults.