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Vitamin B 12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders.The role of B 12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored.itamin B 12 deficiency, therefore, can lead to increased levels of serum methylmalonic acid. In the second reaction, homocysteine is converted to methionine by using vitamin B 12 and folic acid as cofactors. In this reaction, a deficiency of vitamin B 12 or folic acid may lead to increased homocysteine levels.
Vitamin B12 deficiency. Vitamin B12 is important for the way the body works, and people who don't have enough of it may feel tired or have a lack of energy. Vitamin B12 helps in the production of healthy red blood cells that carry oxygen around the body.Not having enough vitamin B12 is called vitamin B12 deficiency anaemia.itamin B12 deficiency. Vitamin B12 is important for the way the body works, and people who don't have enough of it may feel tired or have a lack of energy. Vitamin B12 helps in the production of healthy red blood cells that carry oxygen around the body.