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Vitamin B 12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders.The role of B 12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored.itamin B 12 deficiency, therefore, can lead to increased levels of serum methylmalonic acid. In the second reaction, homocysteine is converted to methionine by using vitamin B 12 and folic acid as cofactors. In this reaction, a deficiency of vitamin B 12 or folic acid may lead to increased homocysteine levels.
Definition. Vitamin B12 helps in red blood cell formation, production of DNA, and function of the nervous system. Vitamin B12 deficiency can occur when the body needs more vitamin B12 than it receives from the diet. Alternatively, the condition may occur when the body is unable to use the vitamin B12 from the diet.A shortage of vitamin B12 can lead to anemia.itamin B12 helps in red blood cell formation, production of DNA, and function of the nervous system. Vitamin B12 deficiency can occur when the body needs more vitamin B12 than it receives from the diet.