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DNA and histone proteins are packaged into structures called chromosomes. In the nucleus of each cell, the DNA molecule is packaged into thread-like structures called chromosomes. Each chromosome is made up of DNA tightly coiled many times around proteins called histones that support its structure.
A: Chromosomes are made of long aggregates of genes formed from condensed chromatin. Chromatin is made up of DNA, proteins, RNA and other macromolecules. It is located in the nucleus of a cell and becomes a chromosome during the prophase stage of mitosis in eukaryotic cell division.