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Benadryl Dosage for Dogs: It is administered by giving 1 milligram for every pound of a dogâs weight after every 8 hours or three times per day. A good example would be, a dog weighing 40lb should take 40mg of Benadryl three times within a single day.
But there are other questions you should ask your vet: how much Benadryl can I give my dog, and is Benadryl safe for dogs. The general guideline for how much Benadryl can I give my dog is 1mg of Benadryl (diphenhydramine) for each pound of body weight, 3 times per day (which means every 8 hrs).