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Vitamin B 12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders.The role of B 12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored.itamin B 12 deficiency, therefore, can lead to increased levels of serum methylmalonic acid. In the second reaction, homocysteine is converted to methionine by using vitamin B 12 and folic acid as cofactors. In this reaction, a deficiency of vitamin B 12 or folic acid may lead to increased homocysteine levels.
What causes a vitamin B12 deficiency? There are many potential causes of a vitamin B12 deficiency. One of the richest food sources of this important vitamin is red meat and organ meats. Because of this, vegetarianâ¦s and vegans can become deficiency in vitamin B12. Other problems can be associated with digestive issues, age, and alcohol or substance abuse.