1 Non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) increase the chance of a heart attack or stroke, either of which can lead to death. 2  There are a large number of studies that support this finding, with varying estimates of how much the risk is increased, depending on the drugs and the doses studied.
Symptoms of thalassemia may include one or more of the following: 1  Paleness. 2  Tiredness, low energy, or muscle weakness (also called fatigue) 3  Lightheadedness or shortness of breath.  Lack of 1  appetite. Dark urine.  Jaundice (yellowing of the skin and the whites of the 1  eyes) In children, slow growth and delayed puberty.  Bone deformities in the face.
Fatigue Cause No. 5: Depression. You may think of depression as an emotional disorder, but it contributes to many physical symptoms as well. Fatigue, headaches, and loss of appetite are among the most common symptoms. If you feel tired and down for more than a few weeks, see your doctor.atigue Cause No. 4: Anemia. Anemia is one of the leading causes of fatigue in women. Menstrual blood loss can cause an iron deficiency, putting women at risk. Red blood cells (shown here) are needed because they carry oxygen to your tissues and organs.