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Vitamin B 12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders.The role of B 12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored.itamin B 12 deficiency, therefore, can lead to increased levels of serum methylmalonic acid. In the second reaction, homocysteine is converted to methionine by using vitamin B 12 and folic acid as cofactors. In this reaction, a deficiency of vitamin B 12 or folic acid may lead to increased homocysteine levels.
Itâs Vitamin B12. Experts estimate that up to 20% of people aged 50 and over may be low in vitamin B12, with this deficiency becoming more common as people get older. Itâs common, serious, and worst of all, commonly overlooked until it causes significant health problems.itamin B12 deficiency is often missed because the symptoms â fatigue, anemia, neuropathy, memory problems, or walking difficulties â are quite common in older adults, and can easily be caused by something else.