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Aldosterone, like ADH also acts on the distant tubules, but also at the kidneyâs collecting ducts. Water retention with the aid of aldosterone is more complex because it has to undergo the Sodium-Potassium exchange channels. In this set-up, potassium is excreted while sodium is retained.
1 Aldosterone stimulates Na + and water reabsorption from the gut, salivary and sweat glands in exchange for K 2  + . Aldosterone stimulates secretion of H + in exchange for K + in the intercalated cells of the cortical collecting tubules, regulating plasma bicarbonate (HCO 3 â) levels and its acid/base balance. (The increased potassium level works to regulate aldosterone synthesis by depolarizing the cells in the zona glomerulosa, which opens the voltage-dependent calcium channels .) The level of angiotensin II is regulated by angiotensin I, which is in turn regulated by renin, a hormone secreted in the kidneys.