(Redirected from Opportunistic infections) An opportunistic infection is an infection caused by pathogens (bacteria, viruses, fungi, or protozoa) that take advantage of an opportunity not normally available, such as a host with a weakened immune system, an altered microbiota (such as a disrupted gut flora), or breached integumentary barriers.
If someone is described as being 'rough around the edges' it means they are generally good but have a few faults on the outside. Rough around the edges has many meanings: Worn out; Not polished or refined; Not great but not bad either; ans Unkempt.
If something or someone frays at the edges or frays around the edges, they gradually become weaker or less successful. The government's army has begun to fray at the edges. By this time, their partnership had begun to fray around the edges. Note: You can also talk about something being frayed at the edges or frayed around the edges. At 72, his voice is sometimes a little frayed around the edges, but that just adds to its charm. Note: If a piece of cloth or rope frays, its threads or fibres start to come apart.