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Vitamin B 12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders.The role of B 12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored.itamin B 12 deficiency, therefore, can lead to increased levels of serum methylmalonic acid. In the second reaction, homocysteine is converted to methionine by using vitamin B 12 and folic acid as cofactors. In this reaction, a deficiency of vitamin B 12 or folic acid may lead to increased homocysteine levels.
Vol. 5 No. 1 P. 30. A vitamin B12 deficiency is most often caused by digestive system difficulties, which can occur if the body is unable to absorb B12 from foods and liquids. Most frequently this is due to a lack of intrinsic factor from the stomach or insufficient acid in the stomach.ol. 5 No. 1 P. 30. A vitamin B12 deficiency is most often caused by digestive system difficulties, which can occur if the body is unable to absorb B12 from foods and liquids. Most frequently this is due to a lack of intrinsic factor from the stomach or insufficient acid in the stomach.