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Vitamin B 12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders.The role of B 12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored.itamin B 12 deficiency, therefore, can lead to increased levels of serum methylmalonic acid. In the second reaction, homocysteine is converted to methionine by using vitamin B 12 and folic acid as cofactors. In this reaction, a deficiency of vitamin B 12 or folic acid may lead to increased homocysteine levels.
Vitamin B12 Deficiency and Brain Damage. I found it hard to see how things as seemingly far apart on the importance spectrum as vitamin B12 deficiency and brain damage could be related. To me, Vitamin B12 Deficiency sounded innocuous, while Brain Damage sounded horrifying.So, Iâm not surprised that people are incredulous when I tell them about the risks of low B12, and that in fact vitamin B12 deficiency can cause brain damage. Plus, at first glance it probably doesnât seem like I have brain damage.So, maybe the place to start is a description of my experience with brain damage. found it hard to see how things as seemingly far apart on the importance spectrum as vitamin B12 deficiency and brain damage could be related.