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Any hormone imbalance in your body could also cause edema to accumulate in your legs. Since gravity will always carry the fluid to the lowest part of your body, it is usually first becomes evident in the lower legs or feet. Vein malfunction / vein dysfunction is also another common cause of leg swelling.
Make sure to talk to your doctor if you suspect that your medication is causing swelling in your lower extremities. Donât stop taking your medication until you speak with your doctor. Other possible causes for foot, leg, and ankle swelling include certain medical conditions or body changes, such as: Natural hormonal changes: Fluctuating levels of estrogen and progesterone can cause reduced circulation in the legs, resulting in swelling.