Mechanism of Action. Gilenya is a sphingosine 1-phosphate receptor modulator and binds with high affinity to sphingosine 1-phosphate receptors 1, 3, 4, and 5. Fingolimod-phosphate blocks the capacity of lymphocytes to egress from lymph nodes, reducing the number of lymphocytes in peripheral blood.ilenya is specifically indicated for the treatment of patients with relapsing forms of multiple sclerosis to reduce the frequency of clinical exacerbations and to delay the accumulation of physical disability. Gilenya is supplied as a capsule designed for oral administration.
Canine pregnancy lasts for approximately 63 days, but ranges from 57 to 72 days from a single breeding. This is due to the variability in the ovulation timing and semen survival in the female dog. During this time hormonal and physical changes develop and are observed in the female.
puppies image by Bobi from Fotolia.com. The period of pregnancy in dogs is called gestation. During gestation the puppies develop in the mother's uterus. Average gestation in dogs lasts approximately nine weeks, or 63 days. However, puppies can be born as early as 58 days or as late as 68 days.nlike humans, pregnancy in dogs cannot be confirmed with a urine or blood test. Instead, veterinarians rely on feeling a dog's abdomen 26 to 35 days after breeding for signs. However, this proves only 85 percent accurate. Owners may need to wait 45 days after breeding to see true confirmation on an X-ray.