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Noun. 1. induration-any pathological hardening or thickening of tissue. sclerosis. disseminated multiple sclerosis, disseminated sclerosis, MS, multiple sclerosis-a chronic progressive nervous disorder involving loss of myelin sheath around certain nerve fibers.
Medical Definition of induration. 1  1: an increase in the fibrous elements in tissue commonly associated with inflammation and marked by loss of elasticity and pliability : sclerosis. 2  2: a hardened mass or formation.