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Usually, receptors are proteins found on or within the membrane. Many different types of molecules can bind to receptors on the cell surface, including hormones. An insulin receptor is an example of a receptor that binds to a hormones, specifically insulin.
Several regulatory sequences in the promoter region of the human insulin gene bind to transcription factors. In general, the A-boxes bind to Pdx1 factors, E-boxes bind to NeuroD, C-boxes bind to MafA, and cAMP response elements to CREB. There are also silencers that inhibit transcription.