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Subcutaneous emphysema can be caused by medical procedures and medical conditions that cause the pressure in the alveoli of the lung to be higher than that in the tissues outside of them. Its most common causes are pneumothorax and a chest tube that has become occluded by a blood clot or fibrinous material.
Causes of Emphysema. The most common emphysema causes are from breathing in fumes and other irritants that damage the lungs and airways. Cigarette smoking is the most common irritant that causes the disease, but other factors (including dust and genetics) can cause it as well.