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Vitamin B 12 (cobalamin) deficiency is a common cause of macrocytic anemia and has been implicated in a spectrum of neuropsychiatric disorders.The role of B 12 deficiency in hyperhomocysteinemia and the promotion of atherosclerosis is only now being explored.itamin B 12 deficiency, therefore, can lead to increased levels of serum methylmalonic acid. In the second reaction, homocysteine is converted to methionine by using vitamin B 12 and folic acid as cofactors. In this reaction, a deficiency of vitamin B 12 or folic acid may lead to increased homocysteine levels.
Vitamin B12 Deficiency. Poor nutrition or inadequate intake of vitamin B12 can cause B12 deficiency. Vitamin B12 food sources include animal products such as meat, poultry, fish, clams, oysters, eggs and dairy products.Fortified breakfast cereals also provide vitamin B12.itamin B12 Deficiency. Poor nutrition or inadequate intake of vitamin B12 can cause B12 deficiency. Vitamin B12 food sources include animal products such as meat, poultry, fish, clams, oysters, eggs and dairy products.