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The 5-HT1B receptor as an example of a metabotropic serotonin receptor. The serotonin receptors, also known as 5-hydroxytryptamine receptors or 5-HT receptors, are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission.
Serotonin can affect cells through proteins on their surface called serotonin receptors. There are seven different kinds of these receptors and one of them, the 5-HT3 receptor is a calcium channel. This particular serotonin receptor is found in the auditory pathways in the brain and may have a role in the development of tinnitus so my track record of work on calcium channels has a direct relevance to this project. What is serotonin?