(IS, 4S)-4-(3, 4-dichlorophenyl)-l, .2, 3, 4- tetrahydro-N-metihyl-1-naphthalenamine, commonly known as Sertraline, is marketed in the form of its hydrochloride salt. Sertraline is used in the treatment of depression, obsessive-compulsive disorder and panic disorder.UMMARY OF THE INVENTION. The present invention discloses a novel method for the preparation of racemic sertraline starting from the known tetralone and cis(+) sertraline hydrochloride form II from cis(+) sertraline mandelate.
The mitral valve (also known as the bicuspid valve or left atrioventricular valve) is a dual-flap (bi-from the Latin, meaning double, and mitral-from the Latin, meaning shaped like a mitre) valve in the heart that lies between the left atrium (LA) and the left ventricle (LV).
mitral valve the cardiac valve between the left atrium and left ventricle, usually having two cusps (anterior and posterior). Called also bicuspid valve. Valves of the heart. The right heart pumps the venous blood into the lungs. The oxygenated blood returns from the lungs into the left atrium and is propelled by the left ventricle into the aorta. The insets show closed valves: the tricuspid valve has three leaflets, whereas the mitral valve has two leaflets.