1 Non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) increase the chance of a heart attack or stroke, either of which can lead to death. 2  There are a large number of studies that support this finding, with varying estimates of how much the risk is increased, depending on the drugs and the doses studied.
Symptoms of thalassemia may include one or more of the following: 1  Paleness. 2  Tiredness, low energy, or muscle weakness (also called fatigue) 3  Lightheadedness or shortness of breath.  Lack of 1  appetite. Dark urine.  Jaundice (yellowing of the skin and the whites of the 1  eyes) In children, slow growth and delayed puberty.  Bone deformities in the face.
Causes Thalassemia is caused by mutations in the DNA of cells that make hemoglobin â the substance in your red blood cells that ... The mutations that cause thalassemia disrupt the normal production of hemoglobin and cause low hemoglobin levels and a high rate of red ... A lower-than-normal red blood cell count can have many causes, including: anemia; bone marrow failure; kidney disease causing a deficiency of ...