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Noun. 1. induration-any pathological hardening or thickening of tissue. sclerosis. disseminated multiple sclerosis, disseminated sclerosis, MS, multiple sclerosis-a chronic progressive nervous disorder involving loss of myelin sheath around certain nerve fibers.
sclerosis. an induration or hardening, especially of a part from inflammation, or in disease of the interstitial substance. The term is used chiefly for such a hardening of the nervous system due to hyperplasia of the connective tissue or for hardening of the blood vessels.Called also induration. adj., adj sclerotÂ´ic.uberous sclerosis a congenital heredofamilial disease, transmitted as an autosomal dominant trait, characterized principally by the presence of hamartomas of the brain (tubers), retina (phakomas), and viscera, mental retardation, seizures, and adenoma sebaceum, and often associated with other skin lesions.