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The most common skin disorders that a vitamin D allergy can cause include hives and eczema, according to Drugs.com. Both allergic skin conditions are extremely itchy and cause inflammation and irritation in the skin. Hives may indicate a severe allergic reaction and needs to be evaluated by a physician.
Vitamin D may interfere with the way the body processes certain drugs using the liver's cytochrome P450 enzyme system. As a result, the levels of these drugs may be altered in the blood, and may cause altered effects or potentially serious adverse reactions.