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an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
antigen. Substance that the body recognizes as foreign; evokes an immune response. Most antigens are proteins or protein fragments found on the surface of bacteria, viruses, or organ transplant tissue cells. cell (B lymphocyte). Lymphocyte that originates in the bone marrow and transforms into a plasma cell to secrete antibodies. The B refers to the bursa of Fabricius, an organ in birds in which B cell differentiation and growth were first noted to occur.