Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
1.Demographic factors like the population composition,size and location does affect the business environment. 2.Political interventions and environment one way or the other â¦ largely affects the business environment.3.The Legal environment also affects the business environment. 4. Economic factors like, Inflation, interest rate on loans, exchange rate systems..Demographic factors like the population composition,size and location does affect the business environment. 2.Political interventions and environment one way or the other â¦ largely affects the business environment.