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A decongestant (or nasal decongestant) is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper respiratory tract.The active ingredient in most decongestants is either pseudoephedrine or phenylephrine (the latter of which has disputed efficacy).These are alpha-agonists which on topical application as dilute solution (0.05-0.1%) produce local vasoconstriction.he active ingredient in most decongestants is either pseudoephedrine or phenylephrine (the latter of which has disputed efficacy). These are alpha-agonists which on topical application as dilute solution (0.05-0.1%) produce local vasoconstriction.
Youâll want a decongestant, like pseudoephedrine or phenylephrine. A decongestant will help reduce nasal tissue swelling. If youâre dealing with allergies or a runny nose, you should look for an antihistamine, like diphenhydramine for nighttime use or non-drowsy fexofenadine.Products containing pseudoephedrine can be found behind your pharmacistâs counter.hinitis just means that the mucus membranes inside your nose are inflamed. Your runny nose could be caused by an infection (like a cold or the flu) or by cold weather, allergies, crying, irritating smells, or particles in the air.