Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
How Macroenvironment Factors Affect Business Strategy. Macro-environment consists of demographic environment, economic environment, natural factors, technological factors, political factors and cultural factors. Let discuss each in detail how they affect business strategy.1  Demographic Environment. 2  Economic environment.ompanies get resources from the environment and supplies goods and services to the environment. There are different environmental factors that affect a business ability to serve its customers.