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myasthenia gravis myasthenia gravÂ·is (grÄv'Ä­s) n. A disease characterized by progressive fatigue and generalized weakness of the skeletal muscles, especially those of the face, neck, arms, and legs, caused by impaired transmission of nerve impulses following an autoimmune attack on acetylcholine receptors. Also called Goldflam disease.
Myasthenia gravis is an autoimmune condition that affects the nerves and muscles. Autoimmune conditions are caused by the body's immune system mistakenly attacking healthy tissue. In myasthenia gravis, the immune system produces antibodies (proteins) that block or damage muscle receptor cells.