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This small nucleus contains almost half of all the brain neurons that use norepinephrine as a neurotransmitter. The locus coeruleus also projects its axons to those parts of the brain that may be associated with panic disorders (the amygdala, hippocampus, septum, cortex, brainstem, reticular formation, etc). Stimulating an animal's locus coeruleus, like stimulating its amygdala, produces anxiety behaviours.
How MS Causes Anxiety. Multiple sclerosis can cause anxiety within the brain itself. But the actual reason that MS tends to cause anxiety is simply because the disease is scary. It's not the fact that MS affects your brain that leads to anxiety. Many of those with MS have frightening symptoms and recurrent, relapsing, progressively worse MS.