Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
Macro factors affecting business environment. 1  1. MACRO FACTORS AFFECTING BUSINESS ENVIRONMENT SUBMITTED BY: AAYUSH VERMA. 2  2. 3  INTRODUCTIONA business firm is an open system. 4  It gets resources from the environment and supplies itsgoods and services to the environment.acro factors affecting business environment. 1  1. MACRO FACTORS AFFECTING BUSINESS ENVIRONMENT SUBMITTED BY: AAYUSH VERMA. 2  2. 3  INTRODUCTIONA business firm is an open system. 4  It gets resources from the environment and supplies itsgoods and services to the environment.