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myasthenia gravis myasthenia gravÂ·is (grÄv'Ä­s) n. A disease characterized by progressive fatigue and generalized weakness of the skeletal muscles, especially those of the face, neck, arms, and legs, caused by impaired transmission of nerve impulses following an autoimmune attack on acetylcholine receptors. Also called Goldflam disease.
Back to TopCauses. Myasthenia gravis is a type of autoimmune disorder. An autoimmune disorder occurs when the immune system mistakenly attacks healthy tissue. In people with myasthenia gravis, the body produces antibodies that block the muscle cells from receiving messages (neurotransmitters) from the nerve cell. Antibodies are proteins made by the body's immune system when it detects harmful substances.