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From Wikipedia, the free encyclopedia. An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. For example, the epitope is the specific piece of the antigen to which an antibody binds. The part of an antibody that binds to the epitope is called a paratope.
An antigen is a substance that can invoke an immune response. While an antibody is the immune system's response to an antigen. Antibodies, act by directly neutralizing the antâ¦igen and/or bind to the antigen and signaling marcophages to phagocytose the antigen.