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myasthenia gravis myasthenia gravÂ·is (grÄv'Ä­s) n. A disease characterized by progressive fatigue and generalized weakness of the skeletal muscles, especially those of the face, neck, arms, and legs, caused by impaired transmission of nerve impulses following an autoimmune attack on acetylcholine receptors. Also called Goldflam disease.
Myasthenia gravis is a long-term condition that typically has phases when it improves and phases when it gets worse. It usually affects most of the body, spreading from the eyes and face to other areas over weeks, months or years. But in around one in five people, only the eye muscles are affected.