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OPANAÂ® ER is an opioid agonist indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Limitations of Use.
Half-life has a direct effect on how long withdrawal will last as well as on how long the substance will show up in drug tests. The half-life of Opana ER ranges from 9.4 hours to 11.3 hours, but there are some factors that can affect how long the drug actually remains in the system. These include: Version: Opana ER is an extended-release version of the drug, which means it has a longer half-life.