Figure Detail. Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.igure Detail. Insertion or deletion of one or more nucleotides during replication can also lead to another type of mutation known as a frameshift mutation. The outcome of a frameshift mutation is complete alteration of the amino acid sequence of a protein.
The female hormone, estrogen affects joints by keeping inflammation down, therefore, as estrogen levels begin to decline during perimenopause, joints get less and less estrogen and pain is often the result.oint pain is defined as pain/ache, stiffness or swelling in or around a joint. Menopause joint pain is usually associated with osteoporosis and arthritis. Osteoporosis â thinning of the bone due to the inability of the body to produce bone tissue.
The average length of perimenopause is 4 years, but for some women this stage may last only a few months or continue for 10 years.Perimenopause ends when a woman has gone 12 months without having her period.omen in perimenopause have at least some these symptoms: 1  Hot flashes. 2  Breast tenderness. 3  Worse premenstrual syndrome. 4  Lower sex drive. 5  Fatigue. 6  Irregular periods. 7  Vaginal dryness; discomfort during sex. 8  Urine leakage when coughing or sneezing. 9  Urinary urgency (an urgent need to urinate more frequently). 10  Mood swings. 11  Trouble sleeping.