Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
The main factors which could influence the marketing mix are: - Finance: The business should consider how much money is to be spent on marketing. - Needs of the market: The bu â¦ siness should continue to carry out market research as the business grows, as the needs of customers change over time.romotion mix, in marketing, involves selling, sales promotions,  public relations and advertising. Factors that affect this include  a product's life cycle and the stage in â¦ which it currently is,  product features, buyer readiness, distribution type and buyer  types. Krissel Diwata.