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From Wikipedia, the free encyclopedia. An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. For example, the epitope is the specific piece of the antigen to which an antibody binds. The part of an antibody that binds to the epitope is called a paratope.
An antigen is a substance that enters the body and stimulates the production of an antibody to fight what the immune system perceives as an invader. Antigens can be toxins, bacteria, foreign blood cells and the cells of transplanted organs.