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an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
(ep'i-tÅp), 1  The simplest form of an antigenic determinant on a complex antigenic molecule, which can combine with antibody or T cell receptor. [ 2 epi- + -tope] 3  A localized region on the surface of an antigen capable of eliciting an immune response and of combining with a specific antibody to counter that response.