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This small nucleus contains almost half of all the brain neurons that use norepinephrine as a neurotransmitter. The locus coeruleus also projects its axons to those parts of the brain that may be associated with panic disorders (the amygdala, hippocampus, septum, cortex, brainstem, reticular formation, etc). Stimulating an animal's locus coeruleus, like stimulating its amygdala, produces anxiety behaviours.
Brazilian Researchers Investigate CBD, Anxiety In Humans. In order to test the relationship between cannabidiol (CBD) and anxiety, the Brazilian research team recruited 10 people with a diagnosis of Social Anxiety Disorder (SAD). They then used functional neuroimaging to gauge the amount of bloodflow in various parts of the brain, noting the effects of CBD.