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This small nucleus contains almost half of all the brain neurons that use norepinephrine as a neurotransmitter. The locus coeruleus also projects its axons to those parts of the brain that may be associated with panic disorders (the amygdala, hippocampus, septum, cortex, brainstem, reticular formation, etc). Stimulating an animal's locus coeruleus, like stimulating its amygdala, produces anxiety behaviours.
Hormones also appear to play a significant role in anxiety development. Those that feel as though their anxieties appeared over time despite effective coping strategies and a high overall quality of life may be suffering from hormonal anxiety, caused by any number of problems with hormone balance.ithout hormones, your body may not produce the right amount of neurotransmitters, and anxiety may be the result. That said, some examples of hormones that may contribute to anxiety include: 1  Stress Hormones (Cortisol) Cortisol and anxiety have a cyclical relationship.