Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
P6 CRITERIA: Describe how political, legal and social factors are impacting upon the business activities of the selected organisations and their stakeholders. Businesses have many factors which can impact upon success in the marketplace. Political, Legal and social being three of the most important factors, which of course businesses must adhere to. A consequence of not adhering to these expectations can result in imprisonment and penalties for owners of the business.