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The average lead time for invitations is six to eight weeks before the wedding; however, destination-wedding invites should be sent anywhere from two to three months ahead of time. If you sent a save-the-date, an invitation is expected to follow.
Get organized about a month before your desired invitation send-out date. This should be six to eight weeks before the wedding, allowing your guests adequate time to respond and ensuring that you will get a reliable head count a week or two before the event.