Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
Socio-cultural factors can affect businesses dramatically, because  a company can be doing well one day, but suddenly see a big  reduction in sales. Changing preferences, ch â¦ anges in demographics,  and faulty advertising methods can affect the socio-cultural  environment of business.3 people found this useful.ocio-cultural factors can affect businesses dramatically, because  a company can be doing well one day, but suddenly see a big  reduction in sales. Changing preferences, ch â¦ anges in demographics,  and faulty advertising methods can affect the socio-cultural  environment of business. 3 people found this useful.