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Back in the mesolimbic pathway, dopamine can play a role in psychosis, and many antipsychotics for treatment of schizophrenia target dopamine. Dopamine is involved in the frontal cortex in executive functions like attention.t has far more roles in the brain to play. For example, dopamine plays a big role in starting movement, and the destruction of dopamine neurons in an area of the brain called the substantia nigra is what produces the symptoms of Parkinsonâs disease.
1 The nigrostriatal system contains about 80% of the brainâs dopamine. 2  This tract projects from cell bodies in the pars compacta of the substantia nigra to terminals that innervate the striatum (caudate and putamen).3  This pathway is involved in motor planning, dopaminergic neurons stimulate purposeful movement.he four pathways relevant to the pharmacology of antipsychotics in the treatment of schizophrenia are: â The mesolimbic pathway (positive symptoms). â The mesocortical pathway (negative symptoms). â The nigrostriatal pathway (extrapyramidal symptoms and tardive dyskinesia).