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an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
antigen. Any substance that can stimulate an immune response in the body and can react with the products of that response, that is, with specific antibodies or specifically sensitized T lymphocytes, or both. Antigens include bacteria, foreign substance (e.g. dust mite, grass, pollen of trees), toxins and viruses.onjugated antigen antigen produced by coupling a hapten to a protein carrier molecule through covalent bonds; when it induces immunization, the resultant immune response is directed against both the hapten and the carrier.