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Considering that dopamine neurotransmission in the nucleus accumbens is thought to play an integral role in goal-directed motor behavior, these findings suggest that the prefrontal cortex influences the behavioral impact of amygdala activation via a concomitant active suppression of accumbal dopamine release.owever, during the stimulation, dopamine release increased only in the prefrontal cortex, not in the nucleus accumbens. An increase in accumbal dopamine release was observed during the stimulation if glutamate activation in the prefrontal cortex was inhibited at either presynaptic or postsynaptic levels.
The mesolimbic pathway, which originates in the middle of the brain and branches to various places like the cerebral cortex, is the most important reward pathway in the brain. One of the mesolimbicâs stops is the nucleus accumbens. Increased dopamine in the nucleus accumbens signals feedback for predicting rewards. Your brain recognizes that something important â good or bad â is about to happen, thus triggering motivation to do something.