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1. karyotype-the appearance of the chromosomal makeup of a somatic cell in an individual or species (including the number and arrangement and size and structure of the chromosomes). physical composition, composition, make-up, makeup, constitution-the way in which someone or something is composed. Translations.
Karyotype. A karyotype results in a picture of someoneâs chromosomes, taken from a single cell. A karyotype can reveal large segments of missing or extra genetic material (e.g., in Down syndrome, there are three copies of chromosome 21; a female with Turner syndrome only has one X chromosome instead of two).aryotype. A karyotype results in a picture of someoneâs chromosomes, taken from a single cell. A karyotype can reveal large segments of missing or extra genetic material (e.g., in Down syndrome, there are three copies of chromosome 21; a female with Turner syndrome only has one X chromosome instead of two).