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From Wikipedia, the free encyclopedia. An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. For example, the epitope is the specific piece of the antigen to which an antibody binds. The part of an antibody that binds to the epitope is called a paratope.
ANTIGEN - A molecule which can be specifically bound by an antibody (typically a. protein or carbohydrate recognized as foreign). EPITOPE (= â antigenic determinantâ =  antigenic specificity) - The minimum. target structure on an antigen which is bound by a particular antibody molecule. A. particular antigen molecule may (and generally does) bear many different epitopes or. âdeterminantsâ, each of which can be a target for antibody binding.