Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
Impact of Business Environment. The impact of business environment in todayâs business Business, now-a-days is vitally affected by the economic, social, legal, technological and political factors. These factors collectively form business environment.valuate the Impact of Changes in the Economic Environment on a Selected Business. Evaluate the impact of changes in the economic environment on a selected business â D1 After various changes to the economic tax and interest rate, CPHP have conducted and compiled research into current public spending.