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The average lead time for invitations is six to eight weeks before the wedding; however, destination-wedding invites should be sent anywhere from two to three months ahead of time. If you sent a save-the-date, an invitation is expected to follow.
More important, though, is the simple courtesy of responding to someone who was nice enough to invite you, even if it is to say that you regret that you will not be able to attend. Many wedding invitations come with a response card that you can mail back right away. Other written invitations will carry the host's telephone number so you can call with your reply, although under strict etiquette rules, a written invitation requires a written reply.