Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
I will discuss elaborately how internal factors can impact a business. I will talk about the most popularly assessed internal factors. The internal business environment comprises of factors within the company which impact the success and approach of operations. Unlike the external environment, the company has control over these factors. It is important to recognize potential opportunities and threats outside company operations. However, managing the strengths of internal operations is the key to business success. The role of company leadership is an essential internal factor.