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This small nucleus contains almost half of all the brain neurons that use norepinephrine as a neurotransmitter. The locus coeruleus also projects its axons to those parts of the brain that may be associated with panic disorders (the amygdala, hippocampus, septum, cortex, brainstem, reticular formation, etc). Stimulating an animal's locus coeruleus, like stimulating its amygdala, produces anxiety behaviours.
New evidence shows that anxiety and most forms of depression are NOT a result of a chemical imbalance or biological problem with the brain. Sadly, a great many people have been duped by the claim that in order to fix their anxiety or depression conditions, they need to fix the chemical imbalance or biological brain problems first.