In 2016, you paid $600 interest on a car loan. During 2016, you used the car 60% for business and 40% for personal purposes. You are claiming actual expenses on the car. You can only deduct $360 (60% Ã $600) for 2016 on Schedule C or C-EZ. The remaining interest of $240 is a nondeductible personal expense.
A nonsense mutation is a point mutation that introduces a premature stop codon into the part of the gene that encodes a protein. A stop codon is like a period at the end of a sentence: it instructs the ribosome to stop making the protein.
The nonsense mutation converts a codon (a triplet of bases) that encodes an amino acid into a stop codon, one that specifies the termination of translation. There are three nonsense codons (UAG, UAA, and UGA) in mRNA. One of them comes normally at the end of each polypeptide. A nonsense codon is a stop codon which is out of place. Catching such a defective messenger RNA (mRNA) before a truncated and potentially harmful protein is synthesized is the job of what is called the nonsense-mediated mRNA decay (NMD) pathway.