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A decongestant (or nasal decongestant) is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper respiratory tract.The active ingredient in most decongestants is either pseudoephedrine or phenylephrine (the latter of which has disputed efficacy).These are alpha-agonists which on topical application as dilute solution (0.05-0.1%) produce local vasoconstriction.he active ingredient in most decongestants is either pseudoephedrine or phenylephrine (the latter of which has disputed efficacy). These are alpha-agonists which on topical application as dilute solution (0.05-0.1%) produce local vasoconstriction.
background. Decongestants relieve nasal and sinus congestion (stuffy nose) caused by allergies or colds. These drugs shrink the tissues and blood vessels in the eyes and nose that swell in response to a cold or contact with an allergen (substance that causes an allergic reaction).nstead, they relieve symptoms of congestion (stuffiness). Most decongestants are available over-the-counter. These drugs can be taken orally or administered through the nose in nasal sprays. Many oral decongestants contain pseudoephedrine (like SudafedÂ® or ActifedÂ®), sometimes in combination with another drug.