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Bake the Brisket. 1  Place a fat-trimmed 3- to 3-1/2-pound fresh beef brisket in a 13x9x2-inch baking pan. 2  Pour the cooking liquid over the meat. 3  Cover the pan with foil. 4  Bake in a 325 degrees F oven about 3 hours or until tender, turning once halfway through cooking time.
1 Cook the brisket fat-side down at 325-375Â°F for 2 to 2-1/2 hours to an internal temperature of 170Â°F. 2  Wrap in foil fat-side up and cook another 2 to 2-1/2 hours until fork tender.3  Rest in foil for 30 minutes before slicing.his should keep the meat at a food-safe temperature of 140Â°F or higher for 2-3 hours. When ready to serve, position the brisket fat-side up (Photo 11) and separate the point section from the flat section along the fat seam. In Photo 12, the point is on the left, the flat is on the right.