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From Wikipedia, the free encyclopedia. An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. For example, the epitope is the specific piece of the antigen to which an antibody binds. The part of an antibody that binds to the epitope is called a paratope.
(ep'i-tÅp), 1  The simplest form of an antigenic determinant on a complex antigenic molecule, which can combine with antibody or T cell receptor. [ 2 epi- + -tope] 3  A localized region on the surface of an antigen capable of eliciting an immune response and of combining with a specific antibody to counter that response.