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The shape of the active site is affected by pH. This is why enzymes will only work at a specific pH, as well as a specific temperature. Change the pH and the enzyme stops working.Increasing the temperature to 60Â°C will cause a permanent change to the shape of the active site. This is why enzymes stop working when they are heated. We say they have become denatured.enaturing of enzymes. The important part of an enzyme is called the active site. This is where specific molecules bind to the enzyme and the reaction occurs. Anything that changes the shape of the active site stops the enzyme from working. This is similar to a key that opens a door lock.
Best Answer: An increase in temperature results in more kinetic energy of the enzyme and the substrate. More kinetic energy results in more collisions between the enzyme and the substrate.In turn, the number of successful collisions increases and more enzyme-substrate complexes form.Therefore an increase in temperature increases the rate at which enzyme substrate complexes form. However, all enzymes have an optimum temperature at which it will work best and favour the activity.Eg. pepsin, an enzyme which works in the stomach has an optimum temperature of between 30-40oC, which is around the human body temperature.o, the rate of enzyme activity decreases once temperature is above its optimum temperature. There is a general rule that every 10oC increase makes the rate double, until the optimum temperature of course. This is called the Q10 effect.