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This small nucleus contains almost half of all the brain neurons that use norepinephrine as a neurotransmitter. The locus coeruleus also projects its axons to those parts of the brain that may be associated with panic disorders (the amygdala, hippocampus, septum, cortex, brainstem, reticular formation, etc). Stimulating an animal's locus coeruleus, like stimulating its amygdala, produces anxiety behaviours.
The limbic system in the core of your brain houses a lot of mood-active structures. The amygdala, in the limbic system, is the center for emotionally charged memories and persistent negative thoughts. It is active during stress, anxiety, and depression. It sits conveniently beside the hippocampus, the part of the brain that serves long-term memory.