Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
1 1. Factors that determine the size of a business Size of capital Number of employees Volume of sales Level of technology Raw materials used Legal form of ownership. 2  2. 3  Size of capital The capital invested by the owner determines the size of business. 3. 2  Number of employees The number of employees employed by any business determines its size. 3  In the case of a small sole trader the owner will do all the work him/herself and possibly appoint a receptionist who will do the administrative duties.