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an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
isotype. [Ä«â²sÉtÄ«p]. an antigenic determinant that occurs in all members of a subclass of an immunoglobulin class. An antigenic determinant that is isotypic in one subclass may appear as an allotypic marker in another class.sotype. [Ä«â²sÉtÄ«p]. an antigenic determinant that occurs in all members of a subclass of an immunoglobulin class. An antigenic determinant that is isotypic in one subclass may appear as an allotypic marker in another class.