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OPANAÂ® ER is an opioid agonist indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Limitations of Use.
1 Overestimating the OPANAÂ® ER dose when converting patients from another opioid product can result in fatal overdose with the first dose.  Accidental ingestion of even one dose of OPANAÂ® ER, especially by children, can result in respiratory depression and death due to an overdose of oxymorphone.