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This small nucleus contains almost half of all the brain neurons that use norepinephrine as a neurotransmitter. The locus coeruleus also projects its axons to those parts of the brain that may be associated with panic disorders (the amygdala, hippocampus, septum, cortex, brainstem, reticular formation, etc). Stimulating an animal's locus coeruleus, like stimulating its amygdala, produces anxiety behaviours.
How Anxiety Can Cause Distorted Reality. Anxiety is its own distorted reality. It changes the way your mind processes information, so that you experience the symptoms of fear when there is no fear around, negative thinking, overthinking, and the tendency for your mind to notice cues that match your psychological expectations.