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myasthenia gravis myasthenia gravÂ·is (grÄv'Ä­s) n. A disease characterized by progressive fatigue and generalized weakness of the skeletal muscles, especially those of the face, neck, arms, and legs, caused by impaired transmission of nerve impulses following an autoimmune attack on acetylcholine receptors. Also called Goldflam disease.
Myasthenia gravis is an autoimmune disorder, in which circulating antibodies cause weakness by blocking acetylcholine receptors at the post-synaptic neuromuscular junction, inhibiting the stimulative effect of the neurotransmitter acetylcholine.yasthenia gravis (MG) is distinguished from congenital myasthenic syndromes (which have similar symptoms) in that MG responds well to immunosuppressive interventions, while congenital myasthenic syndromes do not. Myasthenia gravis more commonly occurs in women under 40 years and men over 60.