Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
Three factors that influence consumer behaviour are: 1. Consumer loyalty - When a consumer returns to you every time or keeps on purchasing from your business. 2. Environmâ¦ent - The environment of your business or where your business is located can affect your consumer e.g.