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1. karyotype-the appearance of the chromosomal makeup of a somatic cell in an individual or species (including the number and arrangement and size and structure of the chromosomes). physical composition, composition, make-up, makeup, constitution-the way in which someone or something is composed. Translations.
A karyotype is the orderly arrangement of chromosomes according to specific rules. The chromosomes arranged on the basis of their size, the biggest on the left to the smalle â¦ st on the right. The centromeres of all the chromosomes are maintained on the same line.