Letterer-Siwe disease, multiple organ involvement. A lesion that affects bone, lung and skin; while histologically indistinct, it is more aggressive than the other forms. Prognosis. Poor if < 18 months at time of diagnosis; haemorrhagic skin lesions; hepatomegaly, anemia; thrombocytopenia; bone marrow involvement.
Cyclical Factors that Affect Business. Any business goes through different business cycles during the course of its existence. These cyclical stages include the ups and downs that a business experiences in terms of its sales volumes, revenues and product lines.
The greatest thing about internal factors is that you have control over most of them. Changing internal factors often involves some indirect costs. Some of the factors are a result of the way you run your business. Example of this includes reputation, credit worthiness, and image. Other factors depend on your business decisions.