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1 Urethral cancer is a disease in which malignant (cancer) cells form in the tissues of the urethra, the tube that carries urine from the bladder to outside the body. It is a rare cancer that occurs more often in women than in men.  Squamous cell carcinoma is the most common type of urethral cancer.
Urothelial Cancer In the United States in 2016, it is estimated that there will be 76,960 new diagnoses of bladder cancer, with approximately 16,390 deaths. Urothelial cancers encompass carcinomas of the bladder, ureters, and renal pelvis, which occur at a ratio of 50:3:1, respectively. Cancer of the urothelium is a multifocal process. Patients with cancer of the upper urinary tract have a 30% to 50% chance of developing cancer of the bladder at some point in their lives.