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Potential side effects of common diabetes drugs*. 1  Sulfonylureas: low blood sugar, upset stomach, skin rash or itching, weight gain. 2  Biguanides/Metformin: sickness with alcohol, kidney complications, upset stomach, tiredness or dizziness, metal taste. 3  Alpha-glucosidase inhibitors: gas, bloating and diarrhoea.
Insulin Ineffectiveness. Now that you know the symptoms of diabetes -- high blood glucose, excessive hunger and thirst, frequent urination -- let's look at what happens to your body during diabetes. For the purposes of this discussion, let's suppose that you have undiagnosed, and therefore unmanaged, diabetes.ow, let's see how the lack of insulin or insulin-resistance affects your body to produce the clinical symptoms and signs of diabetes: Your lack of insulin or insulin resistance directly causes high blood-glucose levels during fasting and after a meal (reduced glucose tolerance).