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However, long-term fatigue and other CFS symptoms can be signs of more serious medical or psychological problems. It is important to rule out other conditions that can cause these symptoms by performing a careful evaluation and laboratory tests. Infectious Mononucleosis and Epstein-Barr Virus. Infectious mononucleosis causes fatigue and swollen glands. It primarily affects adolescents and young adults. Research finds that fatigue may last for a year or more in a small percentage of adolescents who have had mononucleosis. Females and people with more severe fatigue are more likely to develop chronic fatigue syndrome after mononucleosis. Blood tests can detect the Epstein-Barr virus (EBV), which causes mononucleosis. Autoimmune Diseases. Some diseases, including systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis are caused by autoimmunity, a condition in which the person's immune system attacks the body's own tissues.
The most common symptoms of mono are: 1  Fever, which may range from 101Â°F (38.3Â°C) to 104Â°F (40Â°C) , and chills. 2  Sore throat, often with white patches on the tonsils (which may look like strep throat). 3  Swollen lymph nodes all over the body, especially the lymph nodes in the neck.4  Swollen tonsils.5  Headache or body aches.ot everyone infected with the virus that causes mono (Epstein-Barr virus, or EBV) has symptoms. This is especially true for young children, who may have a fever but no other symptoms. People ages 15 to 24 are most likely to have obvious symptoms.