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Interactions With Medications. Even though vitamin B-12 is safe if you take too much, it can interact negatively with certain medications. Chloramphenicol, a type of antibiotic, affects how your body responds to B-12.Even though you're taking a large dose of B-12, the medication limits the vitamin's function.ost vitamins and minerals can be toxic if you take too much. However, vitamin B-12 is a little different. Your system only absorbs a small amount at a time and gets rid of what it doesn't need, which means it's generally safe, even if you take too much.
There are side effects to almost any vitamin if you ingest too much, but there are also side effects if you get too little. Side effects from high levels of B-vitamins, well above the RDA are very rare when taken orally. This is due to the fact that they are water soluble, which allows you to excrete excess amounts through urine.