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1 Cystic fibrosis primarily affects the lungs and digestive system. 2  It leads to the production of mucus that is much thicker and more sticky than usual. 3  Cystic fibrosis is a hereditary condition, caused by a defective gene. 4  The cystic fibrosis gene must be present in both parents for a child to have the condition.
Overview of Cystic Fibrosis. Cystic fibrosis (CF) is the most common fatal, inherited disease in the United States (see Incidence). CF causes the body to produce abnormally thick and sticky mucus in several different parts of the body, most prominently in the lungs and other parts of the respiratory system.It also affects the pancreas, leading to serious digestive problems. Cystic fibrosis alters the mucus secretions of the body's epithelial cells.ust as the chromosomes come in pairs, so do the genes: one copy of the gene on one chromosome is from the mother, the other copy on the other chromosome from the father. The defective gene that is responsible for causing cystic fibrosis is on chromosome 7.