The steady-state plasma concentration that is reached is 4.0 mg/L, so TC = 4.0 mg/L loading dose = 8 mg/hour Vd = loading dose/TC Vd = 8 mg/hour / 4 mg/L = 2 L What is the volume of distribution? CL = kVd t1/2 = 0.7 / k t1/2 = 0.7 Vd/CL Vd = CL * t1/2 / 0.7 Note that Clearance at a steady state can be calculated by: Dose <steady state> = CL * TC, so
As a regulator of sensory information, the thalamus also controls sleep and awake states of consciousness. Function: The thalamus is involved in several functions of the body including: 1  Motor Control. 2  Receives Auditory, Somatosensory and Visual Sensory Signals. 3  Relays Sensory Signals to the Cerebral Cortex.
The thalamus is typically (depending on the animal) ventral and medial in relation to the cortex, and anterior to the midbrain. It lies just ventral from the third ventricle. Its function is to relay information from the sensory organs (except the olfactory system), the hindbrain, midbrain, and the spinal cord to the cortex, hippocampus and basal ganglia. For example, the lateral geniculate nucleus recieves innervation from the retina and relays it to the visual cortex.