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How soon before sexual intercourse should I take Viagra? A good rule of thumb is to take Viagra 45 minutes or an hour before you expect to have sex. After a few hours, its effects lessen considerably, so timing is of a concern. Unfortunately, there's no one-size-fits-all answer to this question.
1 Sildenafil (Viagra). This medication is most effective when taken on an empty stomach one hour before sex. It's effective for up to six hours.  Vardenafil (Levitra, Staxyn). This medication also is most effective when taken one hour before sex and can be taken with or without food.