âThatâs something we can test. If it does, caspase-1 inhibitors mightâand I emphasize mightâbecome a component of a curative cocktail.â G. Doitsh et al., âCell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection,â Nature, doi:10.1038/nature12940, 2013.
Decades ago it was believed that a cascade of enzymes controls the activity of HMG-CoA reductase: an HMG-CoA reductase kinase was thought to inactivate the enzyme, and the kinase in turn was held to be activated via phosphorylation by HMG-CoA reductase kinase kinase.
This enzyme is activated by phosphorylation from ATP by glycogen phosphorylase kinase, activated by cAMP-dependent protein kinase or by Ca 2 + via calmodulin, or inhibited by hydrolysis of the phosphate by glycogen phosphorylase phosphatase.glycogen synthase. an enzyme in the glycogenesis process.lycogen. a polysaccharide, the chief carbohydrate storage material in animals. It is formed and stored in the liver and muscles (phosphorylytically cleaved to glucose-1-phosphate). Called also animal starch. glycogen granules. electron-dense accumulation of glycogen molecules.