The steady-state plasma concentration that is reached is 4.0 mg/L, so TC = 4.0 mg/L loading dose = 8 mg/hour Vd = loading dose/TC Vd = 8 mg/hour / 4 mg/L = 2 L What is the volume of distribution? CL = kVd t1/2 = 0.7 / k t1/2 = 0.7 Vd/CL Vd = CL * t1/2 / 0.7 Note that Clearance at a steady state can be calculated by: Dose <steady state> = CL * TC, so
As a regulator of sensory information, the thalamus also controls sleep and awake states of consciousness. Function: The thalamus is involved in several functions of the body including: 1  Motor Control. 2  Receives Auditory, Somatosensory and Visual Sensory Signals. 3  Relays Sensory Signals to the Cerebral Cortex.
The thalamus receives input from the retina which is relayed to the brain via the optic nerve. Signals are sent to the lateral geniculate nucleus of the thalamus which then forwards them onto the primary visual cortex (area V1) in the occipital lobe.leep and wakefulness. The thalamic nuclei are strongly and reciprocally linked with the cerebral cortex. This forms the thalamo-cortico-thalamic circuits which are thought to regulate consciousness and the thalamus plays a significant role in arousal, wakefulness and alertness.