Dimetapp Paediatric Elixir is contra-indicated in patients sensitive to any of the ingredients and in infants or neonates. It should not be given to patients whose sensitivity to small doses of sympathomimetic substances is manifested by sleeplessness, dizziness, light headaches, weakness, tremulousness or cardiac arrhythmia.
In fact, worrying (or anxiety) can stimulate the release of epinephrine into your system, whereby it will bind with your beta-adrenergic receptors in your liver, causing your blood vessels to constrict and your blood pressure to rise, along with your heart rate (pulse).
Just as in the muscarinic receptor, and most other G protein-coupled receptors that bind biogenic amines, the adrenergic receptors possess an aspartate residue in the third transmembrane domain. The aspartate residue appears to interact with the amine residue of norepinephrine and other adrenergic ligands.pinephrine. Epinephrine is a potent stimulator of both a and b-adrenergic receptors, and its effects on target organs are thus complex. Most of the effects which occur after injection are listed in the table on a and b-receptors shown above.