About SLP. Established in 1987, SLP has stood for quality performance enhancements for late-model American Muscle cars from the beginning, and it continues this commitment today.
Mispriming in PBAT libraries causes methylation bias and poor mapping efficiencies. Random priming in PBAT libraries introduces drastic biases in the base composition and methylation levels especially at the 5â² end of all reads. As a result, affected bases should be removed from the libraries before the alignment step.
DNA methylation occurs where a methyl group is covalently bonded to a cytosine that is immediately followed by a guanine (CpG). The functional result of DNA methylation depends on the location of the methylated CpGs. In many cases it is associated with gene silencing when the CpGs are in the promoter regions. However, methylation can occur within a gene and the observed effect is an increase in transcriptional activity.