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Medications to treat gout attacks. Nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs include over-the-counter options such as ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve, others), as well as more-powerful prescription NSAIDs such as indomethacin (Indocin) or celecoxib (Celebrex).
10-Point Plan: Easing an Acute Gout Attack. A gout attack can be extremely painful. The affected joint becomes swollen, warm to the touch, and very red. Even slight pressure on the joint can be very painful.