Dimetapp Paediatric Elixir is contra-indicated in patients sensitive to any of the ingredients and in infants or neonates. It should not be given to patients whose sensitivity to small doses of sympathomimetic substances is manifested by sleeplessness, dizziness, light headaches, weakness, tremulousness or cardiac arrhythmia.
In fact, worrying (or anxiety) can stimulate the release of epinephrine into your system, whereby it will bind with your beta-adrenergic receptors in your liver, causing your blood vessels to constrict and your blood pressure to rise, along with your heart rate (pulse).
Epinephrine and the skin. The effect of epinephrine on the skin is mainly caused by it binding to alpha-adrenergic receptors, the alpha-2-adrenergic receptor in particular. Restriction of the arteries is caused by the binding of epinephrine to these alpha-adrenergic receptors. This cuts off blood supply to the skin.