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Macrophages are important cells of the immune system that are formed in response to an infection or accumulating damaged or dead cells. Macrophages are large, specialized cells that recognize, engulf and destroy target cells. The term macrophage is formed by the combination of the Greek terms makro meaning big and phagein meaning eat.
Macrophages also stimulate Lymphocytes and other immune cells that react to pathogens as what is called an antigen-presenting cell, also known as a histiocyte. Macrophages are located throughout the bloodstream, and may be fixed or they can be freely motile and capable of amoeboid-like movement. Definition of Macrophage and Its Role in the Body The best definition of macrophage is a white blood cell operating within the body tissues. 2  In humans, macrophages measure approximately 21 micrometers in diameter.