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Potential side effects of common diabetes drugs*. 1  Sulfonylureas: low blood sugar, upset stomach, skin rash or itching, weight gain. 2  Biguanides/Metformin: sickness with alcohol, kidney complications, upset stomach, tiredness or dizziness, metal taste. 3  Alpha-glucosidase inhibitors: gas, bloating and diarrhoea.
If you have diabetes, cortisone injections can raise your blood sugar. If you have an infection, these shots can make it harder to recover. You may not be able to get this treatment if you have problems with blood clotting. Long-term side effects depend on the dose and how often you get this treatment. With higher doses and frequent shots, potential side effects include: 1  Thinning of the skin. 2  Easy bruising. 3  Weight gain. 4  Puffiness of the face. 5  Higher blood pressure.