Abby Jackson Â· Business Insider 01 Sep 2017. South Africa just saw its credit rating downgraded after two of the three major ratings agencies issued depressing assessments of the state of the countryâs economy.
Mastocytosis (say âmas-toe-sigh-toe-sisâ) is a rare disease of the skin (the most common form), or of other parts of the body (very rare), like the stomach, the intestines and the bone marrow.It's caused by having too many mast cells. Mast cells are a kind of blood cell.Mastocytosis can occur at any age.astocytosis (say âmas-toe-sigh-toe-sisâ) is a rare disease of the skin (the most common form), or of other parts of the body (very rare), like the stomach, the intestines and the bone marrow.
Systemic mastocytosis, often termed systemic mast cell disease (SMCD), is a myeloproliferative neoplasm characterized by infiltration of clonally derived mast cells in different tissues, including bone marrow (see the image below), skin, the gastrointestinal tract, the liver, and the spleen.athophysiology. Systemic mastocytosis (systemic mast cell disease) is characterized by mast cell infiltration of extracutaneous organs. Mast cells typically infiltrate the bone marrow and consequently affect the peripheral blood and coagulation system.