This alters the concentration of carbon dioxide in the blood, shifting the above reaction according to Le Chatelier's principle, which in turn alters the pH. The basic reaction governed by this principle is as follows: H2O + CO2 <--> H2CO3 <--> H+ + CO3-.
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As Warren mentioned, in-house designer typically refers to graphic designers hired by businesses to design specifically for their business alone. For example, Whole Foods has their own in-house art director named Kelly Stevens who is involved w...