The steady-state plasma concentration that is reached is 4.0 mg/L, so TC = 4.0 mg/L loading dose = 8 mg/hour Vd = loading dose/TC Vd = 8 mg/hour / 4 mg/L = 2 L What is the volume of distribution? CL = kVd t1/2 = 0.7 / k t1/2 = 0.7 Vd/CL Vd = CL * t1/2 / 0.7 Note that Clearance at a steady state can be calculated by: Dose <steady state> = CL * TC, so
As a regulator of sensory information, the thalamus also controls sleep and awake states of consciousness. Function: The thalamus is involved in several functions of the body including: 1  Motor Control. 2  Receives Auditory, Somatosensory and Visual Sensory Signals. 3  Relays Sensory Signals to the Cerebral Cortex.
The thalamus is involved in several functions of the body including: Motor Control; Receives Auditory, Somatosensory, and Visual Sensory Signals; Relays Sensory Signals to the Cerebral Cortex; Memory Formation and Emotional Expression; Pain Perception; Controls Sleep and Awake States; The thalamus has nerve connections with the cerebral cortex and hippocampus. In addition, connections with the spinal cord allow the thalamus to receive sensory information from the peripheral nervous system and various regions of the body.