This alters the concentration of carbon dioxide in the blood, shifting the above reaction according to Le Chatelier's principle, which in turn alters the pH. The basic reaction governed by this principle is as follows: H2O + CO2 <--> H2CO3 <--> H+ + CO3-.
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Lesson Summary. A matched-pairs design is a type of randomized block design that has two treatment conditions and pairs subjects based on common variables. A block design is one in which an experimenter distributes the subjects of a study into smaller subgroups that have common variables.