âThatâs something we can test. If it does, caspase-1 inhibitors mightâand I emphasize mightâbecome a component of a curative cocktail.â G. Doitsh et al., âCell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection,â Nature, doi:10.1038/nature12940, 2013.
Decades ago it was believed that a cascade of enzymes controls the activity of HMG-CoA reductase: an HMG-CoA reductase kinase was thought to inactivate the enzyme, and the kinase in turn was held to be activated via phosphorylation by HMG-CoA reductase kinase kinase.
Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate. This protein is involved in step 3 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.TP-binding, Magnesium, Metal-binding, Nucleotide-binding. Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. 1  HAMAP-Rule:MF_03184.