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Interactions With Medications. Even though vitamin B-12 is safe if you take too much, it can interact negatively with certain medications. Chloramphenicol, a type of antibiotic, affects how your body responds to B-12.Even though you're taking a large dose of B-12, the medication limits the vitamin's function.ost vitamins and minerals can be toxic if you take too much. However, vitamin B-12 is a little different. Your system only absorbs a small amount at a time and gets rid of what it doesn't need, which means it's generally safe, even if you take too much.
Vitamin B6 (pyridoxine) is a water-soluble vitamin. Although it is a commonly held belief that it is impossible to overdose on a water-soluble vitamin, this is simply not true. A vitamin B6 overdose can cause significant side effects. If you happen to overdose on vitamin B6, seek medical attention immediately. The classic symptom of a vitamin B6 overdose is numbness or unusual sensations (such as tingling), often in the hands or feet. This can lead to coordination problems, due to a lack of sensation in the limbs.