The steady-state plasma concentration that is reached is 4.0 mg/L, so TC = 4.0 mg/L loading dose = 8 mg/hour Vd = loading dose/TC Vd = 8 mg/hour / 4 mg/L = 2 L What is the volume of distribution? CL = kVd t1/2 = 0.7 / k t1/2 = 0.7 Vd/CL Vd = CL * t1/2 / 0.7 Note that Clearance at a steady state can be calculated by: Dose <steady state> = CL * TC, so
As a regulator of sensory information, the thalamus also controls sleep and awake states of consciousness. Function: The thalamus is involved in several functions of the body including: 1  Motor Control. 2  Receives Auditory, Somatosensory and Visual Sensory Signals. 3  Relays Sensory Signals to the Cerebral Cortex.
The thalamus (of which there is one on each side) is a large and important mass of nerve cells or neurons. All sensory pathways (from eyes, ears, skin, etc.), except some of those concerned with the sense of smell, pass through the thalamus on their way to the cerebral cortex.n turn, the fibres of the cells in each thalamic nucleus run up to a particular area (or areas) of the cerebral cortex. Important pathways concerned with the control of movement, from the cerebellum and from motor nuclei called the basal ganglia, also pass through the thalamus.