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Gout occurs when urate crystals accumulate in your joint, causing the inflammation and intense pain of a gout attack. Urate crystals can form when you have high levels of uric acid in your blood. Your body produces uric acid when it breaks down purines â substances that are found naturally in your body, as well as in certain foods, such as steak, organ meats and seafood.
Treatment of asymptomatic hyperuricemia is not necessary. If diuretic-induced gout occurs, it is usually treated with a urate-lowering drug such as allopurinol. The pathogenesis, epidemiology, and an overview of treatment of diuretic-induced hyperuricemia and gout are presented in this topic. The pathophysiology, clinical manifestations, diagnosis, and treatment of acute gouty arthritis as well as the prevention of recurrent gout are discussed separately.