About SLP. Established in 1987, SLP has stood for quality performance enhancements for late-model American Muscle cars from the beginning, and it continues this commitment today.
Mispriming in PBAT libraries causes methylation bias and poor mapping efficiencies. Random priming in PBAT libraries introduces drastic biases in the base composition and methylation levels especially at the 5â² end of all reads. As a result, affected bases should be removed from the libraries before the alignment step.
DNA Methylation Mechanism. In DNA, methylation usually occurs in the CpG islands, a CG rich region, upstream of the promoter region. The letter p here signifies that the C and G are connected by a phosphodiester bond. In humans, DNA methylation is carried out by a group of enzymes called DNA methyltransferases. These enzymes not only determine the DNA methylation patterns during the early development, but are also responsible for copying these patterns to the strands generated from DNA replication.