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Pseudogout is caused by the formation of calcium pyrophosphate crystals in the synovial fluid in the joints. Crystals can also deposit in the cartilage, where they can cause damage.seudogout most often affects the knees, but also affects ankles, wrists, and elbows. General symptoms may include: 1  periodic episodes of joint pain. 2  swelling of the affected joint.
Causes. Pseudogout has been linked to the presence of calcium pyrophosphate dihydrate crystals within the affected joint. These crystals become more numerous as people age, appearing in nearly half the population older than age 85.But most people who have these crystal deposits never develop pseudogout.auses. Pseudogout has been linked to the presence of calcium pyrophosphate dihydrate crystals within the affected joint. These crystals become more numerous as people age, appearing in nearly half the population older than age 85. But most people who have these crystal deposits never develop pseudogout.