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Globular proteins are folded such that their tertiary structure consists of the polar, or hydrophilic, amino acids arranged on the outside and the nonpolar, or hydrophobic, amino acids on the inside of the three-dimensional shape. This arrangement is responsible for the solubility of globular proteins in water.
Not to be confused with globin or globular protein. The globulins are a family of globular proteins that have higher molecular weights than albumins and are insoluble in pure water but soluble in dilute salt solutions. Some globulins are produced in the liver, while others are made by the immune system.Globulins, albumin, and fibrinogen are the major blood proteins. The normal concentration of globulins in human blood is about 2.6-4.6 g/dL. The term globulin is sometimes used synonymously with globular protein.However, albumins are also globular proteins, but are not globulins. All other serum globular proteins are globulins.he normal concentration of globulins in human blood is about 2.6-4.6 g/dL. The term globulin is sometimes used synonymously with globular protein. However, albumins are also globular proteins, but are not globulins.