This alters the concentration of carbon dioxide in the blood, shifting the above reaction according to Le Chatelier's principle, which in turn alters the pH. The basic reaction governed by this principle is as follows: H2O + CO2 <--> H2CO3 <--> H+ + CO3-.
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Despite the design rules and guidelines, the designer still has to make an attractive design, and perhaps using some of these methods. Design by experimentation: experimenting with different shapes, materials, sizes of shapes to optimize functionality and aesthetics of design.