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Interactions With Medications. Even though vitamin B-12 is safe if you take too much, it can interact negatively with certain medications. Chloramphenicol, a type of antibiotic, affects how your body responds to B-12.Even though you're taking a large dose of B-12, the medication limits the vitamin's function.ost vitamins and minerals can be toxic if you take too much. However, vitamin B-12 is a little different. Your system only absorbs a small amount at a time and gets rid of what it doesn't need, which means it's generally safe, even if you take too much.
Certain groups, such as older adults and pregnant women, need larger amounts of some types of vitamin B. Certain conditions, such as Crohnâs disease, Celiac disease, HIV, and misuse of alcohol can result in poor absorption of vitamin B. Symptoms of a deficiency depend on what type of vitamin B you lack. They can range from fatigue and confusion to anemia or a compromised immune system. Skin rashes also can occur.