At a high level, the certification is split into seven different domains: 1  Monitoring and Metrics (15 percent) 2  High Availability (15 percent) 3  Analysis (15 percent) 4  Deployment and Provisioning (15 percent) 5  Data Management (12 percent) 6  Security (15 percent) 7  Networking (13 percent)
Mitochondrial diseases result from failures of the mitochondria, specialized compartments present in every cell of the body except red blood cells. Mitochondria are responsible for creating more than 90% of the energy needed by the body to sustain life and support growth.When they fail, less and less energy is generated within the cell. Cell injury and even cell death follow.henocopies of Mitochondrial Disease. The converse is also true: different mutations in mtDNA and nDNA can lead to the same diseases. In genetics, these are known as phenocopies. A good example is Leigh syndrome, which can be caused by about a dozen different gene defects.
Also, most mitochondrial diseases caused by nDNA mutations (including Leigh syndrome, MNGIE and even MDS) are autosomal recessive, meaning that it takes mutations in both copies of a gene to cause disease. Unlike nDNA, mtDNA passes only from mother to child. Thatâs because during conception, when the sperm fuses with the egg, the spermâs mitochondria â and its mtDNA â are destroyed. Thus, mitochondrial diseases caused by mtDNA mutations are unique because theyâre inherited in a maternal pattern (see illustration below).