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1 Cystic fibrosis primarily affects the lungs and digestive system. 2  It leads to the production of mucus that is much thicker and more sticky than usual. 3  Cystic fibrosis is a hereditary condition, caused by a defective gene. 4  The cystic fibrosis gene must be present in both parents for a child to have the condition.
A defect in the CFTR gene causes cystic fibrosis (CF). This gene makes a protein that controls the movement of salt and water in and out of your body's cells.In people who have CF, the gene makes a protein that doesn't work well. This causes thick, sticky mucus and very salty sweat. defect in the CFTR gene causes cystic fibrosis (CF). This gene makes a protein that controls the movement of salt and water in and out of your body's cells.