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Globular proteins are folded such that their tertiary structure consists of the polar, or hydrophilic, amino acids arranged on the outside and the nonpolar, or hydrophobic, amino acids on the inside of the three-dimensional shape. This arrangement is responsible for the solubility of globular proteins in water.
Difference in structure. A Globular protein is spherical in shape and has the property of forming colloids with water. It gets dissolved in water. Globular proteins are also called as spheroproteins owing to their shape. Fibrous proteins are also called as scleroproteins.roteins are the chemical nutrients that are required for building various tissues of the body as well as needed for repair of worn out cells. Proteins are classified into 3 main groups, namely globular proteins, fibrous proteins and membrane proteins.