âThatâs something we can test. If it does, caspase-1 inhibitors mightâand I emphasize mightâbecome a component of a curative cocktail.â G. Doitsh et al., âCell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection,â Nature, doi:10.1038/nature12940, 2013.
Decades ago it was believed that a cascade of enzymes controls the activity of HMG-CoA reductase: an HMG-CoA reductase kinase was thought to inactivate the enzyme, and the kinase in turn was held to be activated via phosphorylation by HMG-CoA reductase kinase kinase.
The increased glucose does all of the following EXDCEPT. 1  Binds to phosphorylase a at an allosteric site and changes its conformation. 2  Inhibits both glycogen phosphorylase and glycogen synthase. 3  Causes a change in conformation of phosphorylase a that is a better substrate for protein phosphatase.