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Medications to treat gout attacks. Nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs include over-the-counter options such as ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve, others), as well as more-powerful prescription NSAIDs such as indomethacin (Indocin) or celecoxib (Celebrex).
The goal is to treat acute attacks, prevent future attacks, and prevent chronic joint and soft tissue damage caused by chronic tophaceous gouty arthropathy. Long-term gout therapy focuses on reducing serum urate levels by using xanthine oxidase inhibitors (ie, allopurinol, febuxostat) or the uricosuric agent probenecid.