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However, long-term fatigue and other CFS symptoms can be signs of more serious medical or psychological problems. It is important to rule out other conditions that can cause these symptoms by performing a careful evaluation and laboratory tests. Infectious Mononucleosis and Epstein-Barr Virus. Infectious mononucleosis causes fatigue and swollen glands. It primarily affects adolescents and young adults. Research finds that fatigue may last for a year or more in a small percentage of adolescents who have had mononucleosis. Females and people with more severe fatigue are more likely to develop chronic fatigue syndrome after mononucleosis. Blood tests can detect the Epstein-Barr virus (EBV), which causes mononucleosis. Autoimmune Diseases. Some diseases, including systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis are caused by autoimmunity, a condition in which the person's immune system attacks the body's own tissues.
Mono affects about 45 out of 100,000 people, mostly teens and young adults. It usually isn't a serious disease. But it can cause fatigue and weakness that interfere with daily life.