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Gout occurs when urate crystals accumulate in your joint, causing the inflammation and intense pain of a gout attack. Urate crystals can form when you have high levels of uric acid in your blood. Your body produces uric acid when it breaks down purines â substances that are found naturally in your body, as well as in certain foods, such as steak, organ meats and seafood.
Drug treatment is recommended on a long-term basis for: 1  frequent attacks of gout and signs of tophi under the skin (tophi are small white lumps that can form under the skin). 2  evidence of joint damage â either in terms of associated symptoms or damage detected by X-ray. 3  a history of kidney stones.