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Pseudogout is caused by the formation of calcium pyrophosphate crystals in the synovial fluid in the joints. Crystals can also deposit in the cartilage, where they can cause damage.seudogout most often affects the knees, but also affects ankles, wrists, and elbows. General symptoms may include: 1  periodic episodes of joint pain. 2  swelling of the affected joint.
Gout is caused by a build-up of a substance called uric acid in the blood. If you produce too much uric acid or your kidneys don't filter enough out, it can build up and cause tiny sharp crystals to form in and around joints. These crystals can cause the joint to become inflamed (red and swollen) and painful. Things that may increase your chances of getting gout include: