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Interactions With Medications. Even though vitamin B-12 is safe if you take too much, it can interact negatively with certain medications. Chloramphenicol, a type of antibiotic, affects how your body responds to B-12.Even though you're taking a large dose of B-12, the medication limits the vitamin's function.ost vitamins and minerals can be toxic if you take too much. However, vitamin B-12 is a little different. Your system only absorbs a small amount at a time and gets rid of what it doesn't need, which means it's generally safe, even if you take too much.
If you get a good multivitamin, it should have enough of the most active form of vitamin B12 (methylcobalamin). If it doesnât, or if you get deficient in B12 or any of the B complex of vitamins, you should take an extra supplement.Click for a more detailed look at studies of B12 in plant foods by Jack Norris.). I certainly spent a lot of time wondering how much Vitamin B12 should I take before I became a holistic nutritionist.