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Interactions With Medications. Even though vitamin B-12 is safe if you take too much, it can interact negatively with certain medications. Chloramphenicol, a type of antibiotic, affects how your body responds to B-12.Even though you're taking a large dose of B-12, the medication limits the vitamin's function.ost vitamins and minerals can be toxic if you take too much. However, vitamin B-12 is a little different. Your system only absorbs a small amount at a time and gets rid of what it doesn't need, which means it's generally safe, even if you take too much.
It's difficult to overdose on vitamin B, since B vitamins are water soluble and therefore, excess B is excreted through your urine. That said, you can still take too much and suffer symptoms of overdose.f you are taking a B supplement or are concerned that you getting too much, then you should know all there is to know about this important vitamin and how it interacts with your body. There are so many B vitamins that it can be confusing to keep track of them; there are over 20 when all is said and done.