This alters the concentration of carbon dioxide in the blood, shifting the above reaction according to Le Chatelier's principle, which in turn alters the pH. The basic reaction governed by this principle is as follows: H2O + CO2 <--> H2CO3 <--> H+ + CO3-.
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Affinity Labeling (Molecular Biology). Affinity labeling is a strategy to modify chemically an amino acid residue within a specific ligand-binding site of an enzyme, either at the active site or at a regulatory, allosteric site.