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Interactions With Medications. Even though vitamin B-12 is safe if you take too much, it can interact negatively with certain medications. Chloramphenicol, a type of antibiotic, affects how your body responds to B-12.Even though you're taking a large dose of B-12, the medication limits the vitamin's function.ost vitamins and minerals can be toxic if you take too much. However, vitamin B-12 is a little different. Your system only absorbs a small amount at a time and gets rid of what it doesn't need, which means it's generally safe, even if you take too much.
Side Effects of Vitamin B Complex. Side effects of taking a B vitamin complex are not common, especially if the patient takes the medication as prescribed amount. Taking excessive amounts of a vitamin B complex can cause side effects.An overdose is signaled by: dizziness, frequent urination, change in the color of the urine, black stools, constipation, diarrhea, abdominal pain, nausea, vomiting, redness of the skin and itching.ide effects of taking a B vitamin complex are not common, especially if the patient takes the medication as prescribed amount.