The so-called classic catabolic hormones known since the early 20th century are cortisol, glucagon, and adrenaline (and other catecholamines). In recent decades, many more hormones with at least some catabolic effects have been discovered, including cytokines, orexin (also known as hypocretin), and melatonin.
The Medici family, also known as the House of Medici, first attained wealth and political power in Florence in the 13th century through its success in commerce and banking.
Another branch of the family, descended from Silvestroâs distant cousin Giovanni di Bicci deâ Medici, would begin the great Medici dynasty. Giovanniâs elder son, Cosimo (1389-1464), rose to political power in 1434 and ruled Florence as an uncrowned monarch for the rest of his life.