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Anaphylactic reactions are excluded by the presence of red plasma or urine, discordant pretransfusion and posttransfusion ABO blood types, or a positive direct antiglobulin (Coombs) test result. Demonstration of anti-IgA in a pretransfusion sample of the recipient's serum or plasma establishes the diagnosis.
How is a blood transfusion reaction diagnosed? 1  Blood tests: Your blood is tested for signs of destroyed red blood cells. 2  Urine tests: Your urine is tested for blood and for signs of kidney failure.  ECG test: Sticky pads are placed on your skin to record your heart's electrical activity if you have chest pain.