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During the digestive period, intestinal phase signals stimulate the release of bile into the small intestine. Fatty acids in the lumen of the duodenum stimulate endocrine cells to release the hormone cholecystokinin (CCK). CCK stimulates contractions in the smooth muscle of the gallbladder. Views.
The amount of bile secreted into the duodenum is controlled by the hormones cholecystokinin, secretin, gastrin, and somatostatin and also by the vagus nerve. About 800 to 1,000 ml of bile (before concentration) are produced daily by the liver.