In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
1 Kidney problems: Uric acid is normally eliminated by the kidneys. 2  Kidney disease can cause uric acid build-up and gout. 3  But excess uric acid can also damage kidneys. 4  Kidney problems associated with chronic gout -- and signs that chronic gout is getting worse -- include gouty kidney, kidney stones, and kidney failure. Kidney problems associated with chronic gout -- and signs that chronic gout is getting worse -- include gouty kidney, kidney stones, and kidney failure.