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Anaphylactic reactions are excluded by the presence of red plasma or urine, discordant pretransfusion and posttransfusion ABO blood types, or a positive direct antiglobulin (Coombs) test result. Demonstration of anti-IgA in a pretransfusion sample of the recipient's serum or plasma establishes the diagnosis.
The Division of Transfusion Medicine is responsible for the collection and testing of blood to be given to patients at Mayo Clinic (traditional blood banking). The division is also responsible for collecting and processing hematopoietic stem cells for blood and bone marrow transplantation as well as the testing necessary for organ transplantation. Transfusion Medicine also performs therapeutic apheresis procedures to treat patients with neurologic, kidney and blood diseases.