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Anaphylactic reactions are excluded by the presence of red plasma or urine, discordant pretransfusion and posttransfusion ABO blood types, or a positive direct antiglobulin (Coombs) test result. Demonstration of anti-IgA in a pretransfusion sample of the recipient's serum or plasma establishes the diagnosis.
According to the Mayo Clinic, blood transfusions can cause a number of health complications, including allergic reactions, fevers, lung injury, spread of bloodborne infections and acute immune hemolytic reaction - a rare transfusion reaction in which a person's body attacks the new blood because it's not the proper type.