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All parts are affected in some manner, since it is a disease that affects the brain. It is a disease of nervous system. So it affects the parts wherever nerves are and nerves are about everywhere in body. Huntington's is a neurological disease that affects the brain.
The symptoms of Huntington's Disease usually appear between 30 and 50 years of age. But there are exceptions to this. About a quarter of the people affected by HD develop physical symptoms after they turn 50. This is much later than the usual age of onset for HD.