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1 Abdominal pain is caused by inflammation, distention of an organ, or by loss of the blood supply to an organ. Abdominal pain in irritable bowel syndrome (IBS) may be caused by contraction of the intestinal muscles or hyper-sensitivity to normal intestinal activities.  Symptoms associated with abdominal pain may include:
Mid-abdominal pain has many causes. Mid-abdominal pain may arise for a variety of reasons. Many organs and bodily systems are contained within or near the abdomen, so pinpointing the exact cause of pain can be challenging. The American Academy of Family Physicians outlines causes of mid-abdominal pain that include dysfunction within the heart, gallbladder, pancreas, stomach, blood vessels, colon, reproductive organs or kidneys. Some abdominal pain-causing conditions may resolve on their own.