Acetanilide: Acetanilide,, synthetic organic compound introduced in therapy in 1886 as a fever-reducing drug. Its effectiveness in relieving pain was discovered soon thereafter, and it
MidÂ·west. A region of the north-central United States around the Great Lakes and the upper Mississippi Valley. It is generally considered to include Ohio, Indiana, Illinois, Michigan, Wisconsin, Minnesota, Iowa, Missouri, Kansas, and Nebraska. The area is known for its rich farmlands and highly industrialized centers.
Paul, Greater St. Louis, Greater Cleveland, Greater Cincinnati (without the Kentuky portion), Kansas City metro area, and the Columbus metro area. The term Midwestern has been in use since the 1880s to refer to portions of the central United States.