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Insulin and glucagon are hormones that work to regulate the level of sugar (glucose) in the body to keep it within a healthy range. Unlike the acinar cells, the islets of Langerhans do not have ducts and secrete insulin and glucagon directly into the bloodstream. Depending on what youâve eaten, how much exercise your muscles are doing, and how active your body cells are, the amount of glucose in your bloodstream and cells varies.
There are four types of cells in these islets, including: 1  Î± alpha cell that secrete glucagon. 2  Î² beta cells that secrete insulin. 3  Î´ delta cells that secrete somatostatin. 4  Î³ gamma cells that secrete pancreatic polypeptide.