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During the digestive period, intestinal phase signals stimulate the release of bile into the small intestine. Fatty acids in the lumen of the duodenum stimulate endocrine cells to release the hormone cholecystokinin (CCK). CCK stimulates contractions in the smooth muscle of the gallbladder. Views.
Hormones can play a role in the release of digestive secretions. For example, secretin is a hormone produced in the walls of the small intestine that stimulates the liver to produce bile and the pancreas to release bicarbonate, which neutralizes the acidity of the chyme.Cholecystokinin is a hormone produced in the duodenum that stimulates the gallbladder to release bile.ile is produced by the liver and stored in the gallbladder. In this lesson, you will learn about bile and its role in the breakdown of dietary fats. You will also learn how the hormones secretin and cholecystokinin help regulate these organs.