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(For our list of subjects with an imprinting defect, click here.). UBE3A Mutation. Malfunction of the UBE3A gene on the maternal chromosome #15 seems to be the cause of Angelman syndrome. In the case of a UBE3A mutation, there is a mistake in the genetic code of the UBE3A gene.
The idea that the recessive embryonic lethal alleles are leaky dpp ni~ mutations is consistent with ob-servations of interactions with mutations elsewhere in dpp. trans combinations of recessive embryonic lethal or haplo-lethal dpp n~ alleles with either dpp ~sk or dpp shy lesions elicit a variety of phenotypes.