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During the digestive period, intestinal phase signals stimulate the release of bile into the small intestine. Fatty acids in the lumen of the duodenum stimulate endocrine cells to release the hormone cholecystokinin (CCK). CCK stimulates contractions in the smooth muscle of the gallbladder. Views.
Cholecystokinin (CCK) is the major hormone responsible for gallbladder contraction and pancreatic enzyme secretion.CCK, like other gastrointestinal hormones, is produced in discrete endocrine cells that line the mucosa of the small intestine [ 1 ].holecystokinin (CCK) is the major hormone responsible for gallbladder contraction and pancreatic enzyme secretion.