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During the digestive period, intestinal phase signals stimulate the release of bile into the small intestine. Fatty acids in the lumen of the duodenum stimulate endocrine cells to release the hormone cholecystokinin (CCK). CCK stimulates contractions in the smooth muscle of the gallbladder. Views.
Released by: Small intestine (due to presence of acidic chyme-acid in duodenum) 1. Target: Pancreas Action: cause pancreas to release buffers into the small intestine to stabilize pH. 2. Target: Liver cells (hepatocytes) Action: Cause liver to begin making bile.