Amikacin was patented in 1971 and came into commercial use in 1976. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is 13.80 to 130.50 USD for a month.
âOlfactory ciliaâ is a fancy way of saying ânose hairs,â but is important to distinguish between the macroscopic nose hairs near the opening of the nostrils, and the microscopic hairs in the olfactory epithelium, the part of the nose which traps smells and communicates them to the brain.d. The olfactory cilia inside the nose line the mucus membranes of the nose, and unlike most other cilia in the body, they are non-motile, remaining stationary in the nose rather than wiggling around in the mucus like the cilia which line the trachea and intestines do.
The olfactory bulb is a neural structure of the vertebrate forebrain involved in olfaction, the sense of smell. It sends olfactory information to be further processed in the amygdala, the orbitofrontal cortex and the hippocampus where it plays a role in emotion, memory and learning. The bulb is divided into two distinct structures: the main olfactory bulb and the accessory olfactory bulb. The main olfactory bulb connects to the amygdala via the piriform cortex of the primary olfactory cortex and directly projects from the main olfactory bulb to specific amygdala areas. The accessory olfactory bulb resides on the dorsal-posterior region of the main olfactory bulb and forms a parallel pathway.