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Sores in corner of mouth appear again and again when your immune system is not at its optimum. Certain other factors such as constant stress, hormonal changes and poor dental hygiene, digestive disturbances is known to trigger sores in mouth as well as in its corners.
Causes. The precise cause of canker sores remains unclear, though researchers suspect that a combination of factors contributes to outbreaks, even in the same person.Possible triggers for canker sores include: 1  A minor injury to your mouth from dental work, overzealous brushing, sports mishaps or an accidental cheek bite. Inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. 2  Behcet's disease, a rare disorder that causes inflammation throughout the body, including the mouth. 3  A faulty immune system that attacks healthy cells in your mouth instead of pathogens, such as viruses and bacteria.