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Anaphylactic reactions are excluded by the presence of red plasma or urine, discordant pretransfusion and posttransfusion ABO blood types, or a positive direct antiglobulin (Coombs) test result. Demonstration of anti-IgA in a pretransfusion sample of the recipient's serum or plasma establishes the diagnosis.
Having an allergic reaction to the donated blood is a rare complication of a blood transfusion. In 2013, there were 320 reported cases of allergic reactions after a blood transfusion in the UK. An allergic reaction is caused by the bodyâs immune system reacting to proteins or other substances in the donated blood.