In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
Gout Signs & Symptoms. Gout attacks usually strike suddenly, at night, and without any warning. During the attack, the affected joint becomes hot, red, swollen, and extremely tender. The feeling has been described as having a fiery volcano in your toe. Gout may be best known for causing severe pain in the big toe.