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Patients with cardiomyopathy, a stiffening and thickening of the heart muscle that weakens it, may develop an enlarged heart as it labors to pump an adequate supply of blood to the body. Coronary artery disease, in which plaque in the arteries interferes with the flow of blood, can cause the heart to enlarge.
Genetic disorders that cause fat, protein, or other substances to build up; Abnormal growths may cause an enlarged liver. These may be due to: Cysts; Tumors that start in or spread to the liver; A problem with blood flow. This may be due to a variety of conditions such as: Congestive heart failure, a condition where the heart doesn't pump blood well