In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
And as the stereotype suggests, a person with gout usually has other heart attack risk factors. Gout is a kind of arthritis. It's caused by uric acid in the blood which deposit as crystals in the joints and set off the body's inflammatory immune response. Inflammation is part of a process that results in blood clots that can cause heart attack and stroke.