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Hypersecretion of growth hormone causes gigantism in children and acromegaly in adults. Evaluation of growth hormone hypersecretion cannot be excluded with a single normal GH level due to diurnal variation.However, a random blood sample showing markedly elevated GH is adequate for diagnosis of GH hypersecretion.n humans, this condition is caused by over-production of growth hormone in childhood resulting in persons between 2.13 m (7 feet or 84 inches) and 2.74 m (9 feet or 108 inches) in height.
Insulin-like Growth Factor-1 (IGF-1) - IGF-1 levels rise whenever GH levels rise; however, IGF-1 (made mostly in the liver) is released more evenly than GH, and IGF-1 levels remain higher longer. When both of these levels are elevated together, they can also cause many of the signs and symptoms of acromegaly.Somatostatin-One of the main effects of somatostatin is its ability to control the amount of GH in the body. Researchers have taken advantage of this knowledge in developing treatments for acromegaly.hen both of these levels are elevated together, they can also cause many of the signs and symptoms of acromegaly. Somatostatin-One of the main effects of somatostatin is its ability to control the amount of GH in the body. Researchers have taken advantage of this knowledge in developing treatments for acromegaly.