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Hypersecretion of growth hormone causes gigantism in children and acromegaly in adults. Evaluation of growth hormone hypersecretion cannot be excluded with a single normal GH level due to diurnal variation.However, a random blood sample showing markedly elevated GH is adequate for diagnosis of GH hypersecretion.n humans, this condition is caused by over-production of growth hormone in childhood resulting in persons between 2.13 m (7 feet or 84 inches) and 2.74 m (9 feet or 108 inches) in height.
Acromegaly occurs in about 6 of every 100,000 adults. It is caused by abnormal production of growth hormone after the skeleton and other organs finish growing. Excessive production of growth hormone in children causes gigantism rather than acromegaly. The cause of the increased growth hormone release is usually a noncancerous (benign) tumor of the pituitary gland.