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During the digestive period, intestinal phase signals stimulate the release of bile into the small intestine. Fatty acids in the lumen of the duodenum stimulate endocrine cells to release the hormone cholecystokinin (CCK). CCK stimulates contractions in the smooth muscle of the gallbladder. Views.
Stretching of the duodenum accentuates vagal reflexes that stimulate the stomach, and peptides and amino acids in the chyme stimulate G cells of the duodenum to secrete more gastrin, which further stimulates the stomach. Soon, however, the acid and semi-digested fats in the duodenum trigger the enterogastric reflex.