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All parts are affected in some manner, since it is a disease that affects the brain. It is a disease of nervous system. So it affects the parts wherever nerves are and nerves are about everywhere in body. Huntington's is a neurological disease that affects the brain.
Huntington's disease (HD) is a hereditary and progressive brain disorder. You can't catch it from another person. Although symptoms may first show up in midlife, Huntington's can strike anyone from childhood to advanced age. Over 10 to 25 years, the disease gradually kills nerve cells in the brain.