Acetanilide: Acetanilide,, synthetic organic compound introduced in therapy in 1886 as a fever-reducing drug. Its effectiveness in relieving pain was discovered soon thereafter, and it
MidÂ·west. A region of the north-central United States around the Great Lakes and the upper Mississippi Valley. It is generally considered to include Ohio, Indiana, Illinois, Michigan, Wisconsin, Minnesota, Iowa, Missouri, Kansas, and Nebraska. The area is known for its rich farmlands and highly industrialized centers.
However, as david argues, the midwest region globally includes many areas outside of what we traditionally refer to as the midwest, USA. It seems to me that the term midwest arose domestically (likely before 1884), not as a global indicator. Read this from North Dakota State University: http://www.ext.nodak ...