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Anaphylactic reactions are excluded by the presence of red plasma or urine, discordant pretransfusion and posttransfusion ABO blood types, or a positive direct antiglobulin (Coombs) test result. Demonstration of anti-IgA in a pretransfusion sample of the recipient's serum or plasma establishes the diagnosis.
of urine. A freshly voided urine specimen will provide a more accurate test result. If a bacteriologic culture is necessary, the specimen will be collected by catheterization. Because the physical and chemical constituents of normal urine are constant, urinalysis is a valuable diagnostic tool.