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Certain medications may also lead to a low white blood cell count because they can destroy white blood cells or damage the bone marrow. For example, taking antibiotics may sometimes cause an abnormal drop in neutrophils, a condition known as neutropenia.
Things you can do to reduce your risk of infection when you have low white blood count: 1  Frequent hand washing of both you and those coming in contact with you. 2  Avoid contact with anyone who is sick. 3  Do not have dental work done while your white blood cell count is low.OW WHITE BLOOD CELL COUNT (low WBC). Leukopenia-A decrease in the total number of white blood cells, which may lead to low white blood cell count. Neutropenia-A decrease in the number of neutrophils, which may lead to low white blood count.