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Certain medications may also lead to a low white blood cell count because they can destroy white blood cells or damage the bone marrow. For example, taking antibiotics may sometimes cause an abnormal drop in neutrophils, a condition known as neutropenia.
The anti-epileptic drugs phenytoin and phenobarbitone can lower the white cell count as can phenothiazines and penicillin. Deficiency of Vitamin B12 and folate deficiency can also reduce the number of white cells but such deficiency is usually accompanied by other signs in the blood. A low white cell count can also be a feature of autoimmune disease.