1 Apply this paste on your face and neck to eliminate dark spots. 2  Saffron & Honey; A paste of saffron and honey also works wonders on brown spots. 3  Apply the paste and then wash off. 4  Rind of a watermelon: Take the rind of a watermelon and rub on your age spots with it and then wash away with cold water.
LLE redirects here. For other uses, see LLE (disambiguation). The Laboratory for Laser Energetics (LLE) is a scientific research facility which is part of the University of Rochester's south campus, located in Brighton, New York.
Lipophilic efficiency (LiPE), sometimes referred to as ligand-lipophilicity efficiency (LLE) is a parameter used in drug design and drug discovery to evaluate the quality of research compounds, linking potency and lipophilicity in an attempt to estimate druglikeness.igh potency (high value of pIC 50) is a desirable attribute in drug candidates, as it reduces the risk of non-specific, off-target pharmacology at a given concentration. When associated with low clearance, high potency also allows for low total dose, which lowers the risk of idiosyncratic drug reaction.