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During the digestive period, intestinal phase signals stimulate the release of bile into the small intestine. Fatty acids in the lumen of the duodenum stimulate endocrine cells to release the hormone cholecystokinin (CCK). CCK stimulates contractions in the smooth muscle of the gallbladder. Views.
The bile then goes into the gallbladder where it is stored and concentrated for later use. When you eat a fatty meal, a hormone called cholecystokinin (CCK) is secreted. It causes the gallbladder to contract and also causes relaxation of a small valve (the sphincter of Oddi) at the end of the common bile duct. This allows bile to flow into the duodenum and mix with food for digestion. After the CCK effect wears off, the valve closes, the gallbladder relaxes, and the cycle is repeated.