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During the digestive period, intestinal phase signals stimulate the release of bile into the small intestine. Fatty acids in the lumen of the duodenum stimulate endocrine cells to release the hormone cholecystokinin (CCK). CCK stimulates contractions in the smooth muscle of the gallbladder. Views.
A HORMONE released into the blood from the lining of the duodenum when fat and acid are present. It causes the gallbladder to contract and the sphincter of Oddi to relax, so sending bile into the duodenum to emulsify the fat, and stimulates the pancreas to secrete fat- and protein-splitting enzymes. The hormone also inhibits the motility of the stomach and the secretion of gastric acid.