Depolarizationof the axon hillock to threshold results in the generationand propagation of an action potential. The action poten-tial is a transient change in the membrane potential charac-terized by a gradual depolarization to threshold, a rapid ris-ing phase, an overshoot, and a repolarization phase.
Ecology. Staphylococcus aureus is a normal inhabitant of the skin and mucous membranes in the nose of a healthy human, while S. epidermidis inhabits only the skin of healthy humans. S. aureus is infectious to both animals and humans.he Staphylococcus aureus genome, which is the most common species amoung the genome projects, is about 2.8 Mega-base pairs long with approximately 2,600 open reading frames, comprising 84.5% of the genome.
Serotype 5 and 8 capsular polysaccharides predominate among clinical isolates of Staphylococcus aureus. The results of experiments in animal models of infection have revealed that staphylococcal capsules are important in the pathogenesis of S. aureus infections.The capsule enhances staphylococcal virulence by impeding phagocytosis, resulting in bacterial persistence in the bloodstream of infected hosts.psonization of S. aureus is critical for uptake and killing of the bacterium by professional phagocytic cells. Complement and antibody are the principal serum opsonins and have been shown to play an important role in opsonophagocytic killing of the staphylococcus (69, 87, 116, 117).