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A gene mutation is a permanent alteration in the DNA sequence that makes up a gene, such that the sequence differs from what is found in most people.Mutations range in size; they can affect anywhere from a single DNA building block (base pair) to a large segment of a chromosome that includes multiple genes.n some cases, the mutation occurs in a personâs egg or sperm cell but is not present in any of the personâs other cells. In other cases, the mutation occurs in the fertilized egg shortly after the egg and sperm cells unite.
Genes are segments of DNA located on chromosomes. A gene mutation is defined as an alteration in the sequence of nucleotides in DNA. This change can affect a single nucleotide pair or larger gene segments of a chromosome. DNA consists of a polymer of nucleotides joined together.During protein synthesis, DNA is transcribed into RNA and then translated to produce proteins. Altering nucleotide sequences most often results in nonfunctioning proteins. Silent Mutation: Although a change in the DNA sequence occurs, this type of mutation does not change the protein that is to be produced. 2  This is because multiple genetic codons can encode for the same amino acid. 3  Amino acids are coded for by three nucleotide sets called codons.