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All blood donations are processed and available for use usually within 24 hours. Whole blood is processed into components (red blood cells, platelets, plasma). After processing, the red blood cells can be stored for 42 days.
1 Whole blood donation takes approximately 45 to 60 minutes. 2  Donating plasma or platelets (called apheresis or automated donation) takes about 1 1/2 to two hours. 3  The Mayo Clinic Blood Donor Center in Rochester provides televisions, video on demand and wireless Internet access for donors to use during donations. You can donate whole blood as often as every 84 days at the Mayo Clinic Blood Donor Center in Rochester. 2  Plasma donors may donate as often as every 28 days. 3  Platelets donors may donate as frequently as every eight days, and up to 24 times in a 12-month period.