In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
Gout may be caused by some medical drugs, such as: 1  Diuretics (water tablets). 2  Some drugs such as ACE inhibitors or beta blockers used to treat hypertension also increase risk of gout. 3  Niacin which is used to lower cholesterol level. 4  Aspirin which is used to treat abnormal blood clots. 5  Some cancer medicines.