1 itchiness (pruritus). 2  Pruritus is the primary symptom of cholestasis and is thought to be due to interactions of serum bile acids with opioidergic nerves. 3  In fact, the opioid antagonist naltrexone is used to treat pruritus due to cholestasis.ile is secreted by the liver to aid in the digestion of fats. Bile formation begins in bile canaliculi that form between two adjacent surfaces of liver cells (hepatocytes) similar to the terminal branches of a tree.
FICO (NYSE: FICO) is a software company based in San Jose, California and founded by Bill Fair and Earl Isaac in 1956.Its FICO score, a measure of consumer credit risk, has become a fixture of consumer lending in the United States.he company debuted its first general-purpose FICO score in 1989. Scores are based on credit reports and range from 300 to 850. Lenders use the scores to gauge a potential borrower's creditworthiness.
Industry-specific FICO Â® Scores are versions of FICO Â® Scores that are optimized for a certain type of credit product, such as auto loans or credit cards. The foundation of these versions is the same as the base FICO Â® Score versions, but they are fine-tuned based on industry-specific risk behavior.ne reason why there are multiple FICO Â® Score versions is that the FICO Â® Score model is updated periodically, resulting in a new FICO Â® Score version released to market every several years. The most recent FICO Â® Score version that is widely used by lenders is FICO Â® Score 8.