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Anaphylactic reactions are excluded by the presence of red plasma or urine, discordant pretransfusion and posttransfusion ABO blood types, or a positive direct antiglobulin (Coombs) test result. Demonstration of anti-IgA in a pretransfusion sample of the recipient's serum or plasma establishes the diagnosis.
For example, if a unit of blood type A (which contains A antigens) is transfused into someone with type B (they have anti-type A antibodies in their blood), a transfusion reaction will occur. When a transfusion reaction does occur, an antibody attaches to antigens on several red blood cells.hen someone has type A blood (with type A antigens), their plasma has type B antibodies and vice versa. Therefore, a reaction occurs when the antigens on the red blood cells of the donor blood react with the antibodies in the recipient's plasma.