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During the digestive period, intestinal phase signals stimulate the release of bile into the small intestine. Fatty acids in the lumen of the duodenum stimulate endocrine cells to release the hormone cholecystokinin (CCK). CCK stimulates contractions in the smooth muscle of the gallbladder. Views.
When fat globules arrive in the upper reaches of the small intestine, the duodenum, it triggers a hormone. The hormone tells the gallbladder that bile is needed, so the gallbladder does a muscular contraction and dumps a large quantity of bile into the duodenum to deal with the fat.