In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
Gout pain strikes hard, fast, and at any time, especially at night. 1  Gout attacks peak within 12 hours and can last over a week (3-14 days) 2  The risk of gout attacks at night (midnightâ. 3  Half of all gout patients have 3 or more flares per year.