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Anaphylactic reactions are excluded by the presence of red plasma or urine, discordant pretransfusion and posttransfusion ABO blood types, or a positive direct antiglobulin (Coombs) test result. Demonstration of anti-IgA in a pretransfusion sample of the recipient's serum or plasma establishes the diagnosis.
If you have many blood transfusions, you are more likely to have problems from immune system reactions. A reaction causes your body to form antibodies that attack the new blood cells. But tests can help avoid this. Before you get a blood transfusion, your blood is tested to find out your blood type.