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Patients with cardiomyopathy, a stiffening and thickening of the heart muscle that weakens it, may develop an enlarged heart as it labors to pump an adequate supply of blood to the body. Coronary artery disease, in which plaque in the arteries interferes with the flow of blood, can cause the heart to enlarge.
High Blood Pressure. One of the most common reasons of enlarged heart is uncontrolled high blood pressure. High blood pressure makes the heart more stressed causing it to push itself harder to supply the blood to the entire body, which can often lead to the thickening and stiffening of the heart muscles.