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Insulin and glucagon are hormones that work to regulate the level of sugar (glucose) in the body to keep it within a healthy range. Unlike the acinar cells, the islets of Langerhans do not have ducts and secrete insulin and glucagon directly into the bloodstream. Depending on what youâve eaten, how much exercise your muscles are doing, and how active your body cells are, the amount of glucose in your bloodstream and cells varies.
Like insulin, glucagon is a protein hormone produced in the pancreas. It is a counterbalance to insulin. Approximately four to six hours after you eat, the glucose levels in your blood become reduced. This triggers the production of glucagon in the pancreas. When the pancreas secretes glucagon, it suppresses insulin. Glucagon signals the liver and muscles to break down glycogen into glucose and release glucose back into your bloodstream. This keeps your blood sugar levels from dipping too low.