In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
Other complications include the following. 1  Kidney stones (if uric acid crystals collect in your urinary system). 2  Damage to your kidneys (if uric acid crystals collect in them). 3  Cardiovascular disease (such as heart attack and stroke) appears to be associated with gout.