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Patients with cardiomyopathy, a stiffening and thickening of the heart muscle that weakens it, may develop an enlarged heart as it labors to pump an adequate supply of blood to the body. Coronary artery disease, in which plaque in the arteries interferes with the flow of blood, can cause the heart to enlarge.
The risk of complications from an enlarged heart depends on the part of the heart that is enlarged and the cause. Complications of an enlarged heart can include: Heart failure. One of the most serious types of enlarged heart, an enlarged left ventricle increases the risk of heart failure.