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Certain medications may also lead to a low white blood cell count because they can destroy white blood cells or damage the bone marrow. For example, taking antibiotics may sometimes cause an abnormal drop in neutrophils, a condition known as neutropenia.
1 Leukopenia-a decrease in the total number of white blood cells (WBC), which may lead to low white blood cell count. 2  Neutropenia-a decrease in the number of neutrophils, one type of white blood cell, which may lead to low white blood cell count.ow Blood Counts. Includes: Low red blood cell count, Low white blood cell count, Low platelet count, Infection-prevention guidelines for immunosuppressed patients. Other words you may hear: 1  Myelosuppression-a decrease in the production of blood cells, which may lead to low blood count.