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All parts are affected in some manner, since it is a disease that affects the brain. It is a disease of nervous system. So it affects the parts wherever nerves are and nerves are about everywhere in body. Huntington's is a neurological disease that affects the brain.
Do you know which parts of your brain control the different functions in your body? This page explains what the different parts of your brain do. Frontal lobe. The frontal lobe governs our personality, character and behaviour. It is where we control our body movement and how we express ourselves. This part of the brain allows us to speak.