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During the digestive period, intestinal phase signals stimulate the release of bile into the small intestine. Fatty acids in the lumen of the duodenum stimulate endocrine cells to release the hormone cholecystokinin (CCK). CCK stimulates contractions in the smooth muscle of the gallbladder. Views.
The human liver produces approximately 400ml to 800ml of bile each day. Hepatocytes of the liver secrete bile, which is then released into the canaliculi before entering the bile ducts.The bile ducts add to this secretion a liquid rich with bicarbonates. Next, a hormone called cholecystokinin (CCK), causes gall bladder contraction, which discharges bile into the duodenum.he human liver produces approximately 400ml to 800ml of bile each day. Hepatocytes of the liver secrete bile, which is then released into the canaliculi before entering the bile ducts.