In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
The Typical Gout Attack - Sudden Symptoms. 1  The onset of a gout attack is usually quick. Often gout symptoms (warmth, swelling, redness, and pain) begin during the night. 2  Over an 8 to 12 hour period the pain level worsens, going from mere twinges to intense pain. 3  The big toe is affected in 90 percent of people with gout.