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During the digestive period, intestinal phase signals stimulate the release of bile into the small intestine. Fatty acids in the lumen of the duodenum stimulate endocrine cells to release the hormone cholecystokinin (CCK). CCK stimulates contractions in the smooth muscle of the gallbladder. Views.
The duodenum does not actually produce any digestive enzymes, it produces chemicals that are called buffers. The most important are the Brunner's Glands (duodenal glands) whic â¦ h produce mucus which helps to neutralize the acid in the chyme from the stomach.he gallbladder acts as a storage tank that stores the bile produced by the liver. When food enters the small intestine, the gallbladder secretes bile through the bile ducts into the duodenum---the upper portion of the small intestine. 1 person found this useful.