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Anaphylactic reactions are excluded by the presence of red plasma or urine, discordant pretransfusion and posttransfusion ABO blood types, or a positive direct antiglobulin (Coombs) test result. Demonstration of anti-IgA in a pretransfusion sample of the recipient's serum or plasma establishes the diagnosis.
Transfusion reaction accompanies or follows intravenous administration of blood components. Its severity varies from mild (fever and chills) to severe (acute kidney failure or complete vascular collapse and death), depending on the amount of blood transfused, the type of reaction, and the person's general health.