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Patients with cardiomyopathy, a stiffening and thickening of the heart muscle that weakens it, may develop an enlarged heart as it labors to pump an adequate supply of blood to the body. Coronary artery disease, in which plaque in the arteries interferes with the flow of blood, can cause the heart to enlarge.
An enlarged heart is medically known as cardiomegaly. Cardiomegaly can be caused by a number of different conditions, including diseases of the heart muscle or heart valves, high blood pressure, arrhythmias, and pulmonary hypertension.t is important to remember that an enlarged heart is not a disease itself but a physical sign that can accompany many diseases and conditions. Not all of the associated conditions listed below, however, will always result in cardiomegaly. Treatment and prognosis are dependent upon the underlying cause.