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Risk factors for bladder cancer. A risk factor is something that increases the risk of developing cancer. It could be a behaviour, substance or condition. Most cancers are the result of many risk factors. Smoking is the most important risk factor for bladder cancer. The risk of developing bladder cancer increases with age. It usually occurs in people older than 65 years of age. Bladder cancer is most common in Caucasians, and men develop this disease more often than women.
Smoking and other chemical exposure. More than most cancers, bladder cancer is associated with exposure to cancer-promoting chemicals, or carcinogens. Cigarette smoking is the main cause of bladder cancer, with smokers at twice the risk of developing bladder cancer. People exposed to arylamines -- painters, leatherworkers, machinists, metalworkers, and rubber and textile workers -- are at increased risk for bladder cancer, as are those who have had radiation therapy.