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Insulin and glucagon are hormones that work to regulate the level of sugar (glucose) in the body to keep it within a healthy range. Unlike the acinar cells, the islets of Langerhans do not have ducts and secrete insulin and glucagon directly into the bloodstream. Depending on what youâve eaten, how much exercise your muscles are doing, and how active your body cells are, the amount of glucose in your bloodstream and cells varies.
Primary hormones secreted by the pancreas include: 1  Gastrin: This hormone aids digestion by stimulating certain cells in the stomach to produce acid. 2  Glucagon: Glucagon helps insulin maintain normal blood glucose by working in the opposite way of insulin. It stimulates your cells to release glucose, and this raises your blood glucose levels. Insulin: This hormone regulates blood glucose by allowing many of your bodyâs cells to absorb and use glucose.