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Overview. Posttransplant lymphoproliferative disease (PTLD) is an unusual entity that has many features of an immune system malignancy. It is characterized by uncontrolled proliferation of lymphoid lineage cells (typically B cells, rarely non-B lineage) in a context of posttransplant immunosuppression.
Posttransplant lymphoproliferative disorder (PTLD) is a group of lymphatic and plasmacytic proliferations arising in the setting of immunosuppression after transplantation. Histologically, their spectrum ranges from polyclonal early lesions to monomorphic lymphoma.