Contiguous simply means touching or sharing a border, according to Merriam-Webster. When it comes to the United States, contiguous refers to all of the states that touch one another, without another country or a body of water coming between them. These are sometimes also referred to as the lower 48 states.
.apk extension stands for android package file. It is a file format used to distribute and install applications.It includes the programm codes ,assets ,resourses ,certificates and manifest file. .Dex extensions stands for Dalvix Executable files.
The endoplasmic reticulum (ER) resident PKR-like kinase (PERK) is necessary for Akt activation in response to ER stress. We demonstrate that PERK harbors intrinsic lipid kinase, favoring diacylglycerol (DAG) as a substrate and generating phosphatidic acid (PA). This activity of PERK correlates with activation of mTOR and phosphorylation of Akt on Ser473. PERK lipid kinase activity is regulated in a phosphatidylinositol 3-kinase (PI3K) p85Î±-dependent manner. Moreover, PERK activity is essential during adipocyte differentiation.