In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
When too much uric acid builds up around a joint, uric crystal forms, causing a painful gout flare. All sorts of things -- from certain foods and drinks to stress and medicines -- can cause your uric acid levels to go up. Knowing what can trigger the uric acid to build up in your body may help you avoid future gout attacks. Common Gout Triggers