In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
Gout occurs in your joints. You have tremendous pain that leads to swelling and inflammation in the affected area. Gout is believed to be a side effect of high blood sugar, a factor in metabolic syndrome. Itâs also associated with high cholesterol and obesity. Eating a healthy diet and getting proper exercise helps you avoid gout.