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Certain medications may also lead to a low white blood cell count because they can destroy white blood cells or damage the bone marrow. For example, taking antibiotics may sometimes cause an abnormal drop in neutrophils, a condition known as neutropenia.
Infections may cause a temporary decrease in white blood cell count, a condition known as leukopenia. In a severe bacterial infection, white blood cells that normally circulate in the bloodstream migrate to the site of the infection in large numbers, leading to a low white blood cell count in the blood.