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Patients with cardiomyopathy, a stiffening and thickening of the heart muscle that weakens it, may develop an enlarged heart as it labors to pump an adequate supply of blood to the body. Coronary artery disease, in which plaque in the arteries interferes with the flow of blood, can cause the heart to enlarge.
Quick Answer. An enlarged heart is dangerous because it can be indicative of congenital heart problems, arrhythmia, high blood pressure and diseases of the heart valve, according to Mayo Clinic. Kidney disease and HIV infections can also cause an enlarged heart, according to WebMD. Continue Reading.