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During the digestive period, intestinal phase signals stimulate the release of bile into the small intestine. Fatty acids in the lumen of the duodenum stimulate endocrine cells to release the hormone cholecystokinin (CCK). CCK stimulates contractions in the smooth muscle of the gallbladder. Views.
This bicarbonate neutralizes the acid from the stomach in the chyme and protects the duodenum from the acid. When the chyme enters the duodenum, cells in the duodenum release the hormones intestinal gastrin, secretin, cholecystokinin, and gastric inhibitory peptide. Intestinal gastrin initially stimulates the stomach.