In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
The signs and symptoms of gout almost always occur suddenly â often at night â and without warning. They include: 1  Intense joint pain. 2  Gout usually affects the large joint of your big toe, but it can occur in your feet, ankles, knees, hands and wrists.3  The pain is likely to be most severe within the first four to 12 hours after it begins.4  Lingering discomfort. Intense joint pain. 2  Gout usually affects the large joint of your big toe, but it can occur in your feet, ankles, knees, hands and wrists.