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The usual total daily dose is 200 mg to 400 mg in two divided doses. Some patients may require doses up to 800 mg per day which is the maximum dose. It is recommended that therapy be initiated at a low dose, followed by titration to an effective dose.
In the 2005 TNT study, 10,001 people with stable heart disease received either maximum-dose 80-mg LipitorÂ® or a standard dose of 10-mg LipitorÂ® daily. 1 Maximum-dose LipitorÂ® reduced levels of harmful low density lipoprotein (LDL) to an average of 77 mg/dL. This represented a substantial reduction in LDL.