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believe the answer you're looking for has to do with the pressure-altitude-voltage derating related to corona discharge, which increases (gets worse) with higher altitude and peaks at around 80-100,000' Typically this is considered to occur at votlages above 300 V peak, but be sure you are accounting for all transients and internal voltages.
The answer in the Q&A column on Tuesday about the effects of barometric pressure on humans misidentified the part of the ear where the expansion or contraction of air as altitude changes can cause popping and pain.It is the middle ear, not the inner ear.. Differences in air pressure because of the weather or changes in altitude can have noticeable effects on the human body, though some people are more sensitive than others.