When DNA replication starts, one primer is needed at the start of the leading strand. The lagging strand will need new primers regularly, and they mark the start of the stretches known as Okazaki fragments.
The recommended dose of Alimta is 500 mg/m2 administered as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle. The recommended dose of cisplatin is 75 mg/m2 infused over 2 hours beginning approximately 30 minutes after the end of Alimta administration. See cisplatin package insert for more information.
Medications administered more frequently than daily but not more frequently than every 4 hours (e.g., BID, TID, q4h, q6h) Administer these medications plus or minus 1 hour from the scheduled time. Medications administered more frequently than every 4 hours (e.g., q1h, q2h, q3h) Administer these medications within 25% of the dosing interval (e.g., plus or minus 15 minutes for hourly doses, plus or minus 30 minutes for every 2 hours dosing, plus or minus 45 minutes for every 3 hours dosing).