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Mutagenicity is a specific term that refers to a permanent, heritable change in the structure or amount of genetic material of an organism and includes gene mutations as well as structural and numerical alterations in chromosomes (Eastmond et al.
Some mutagens can cause aneuploidy and change the number of chromosomes in the cell. In Ames test, where the varying concentrations of the chemical are used in the test, the dose response curve obtained is nearly always linear, suggesting that there is no threshold for mutagenesis.