Gravette, Arkansas. Gravette is a city in Benton County, Arkansas, United States. The population was 2,325 at the 2010 census. It is part of the FayettevilleâSpringdaleâRogers, AR-MO Metropolitan Statistical Area.
congenital nephrotic syndrome. At least 170 mutations in the NPHS2 gene have been found to cause congenital nephrotic syndrome. This condition is a kidney disorder that begins in infancy and typically leads to irreversible kidney failure (end-stage renal disease) by early childhood.
Nephrotic syndrome is a nonspecific kidney disorder characterized by three signs of disease: large proteinuria, hypoalbuminemia and edema. Essentially, loss of protein through the kidneys (proteinuria) leads to low protein levels in the blood (hypoalbuminemia), which causes water to be drawn into soft tissues (edema).