When DNA replication starts, one primer is needed at the start of the leading strand. The lagging strand will need new primers regularly, and they mark the start of the stretches known as Okazaki fragments.
The recommended dose of Alimta is 500 mg/m2 administered as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle. The recommended dose of cisplatin is 75 mg/m2 infused over 2 hours beginning approximately 30 minutes after the end of Alimta administration. See cisplatin package insert for more information.
1 Intravenous immunoglobulin (IVIg), usually given at a dosage of 400 mg/kg/day for 5 days or in higher doses for 3 days. 2  The procedure may need to be repeated every 4 weeks for several cycles.3  It is very expensive. 4  The use of IVIg for the treatment of skin diseases has recently been reviewed. Pulse therapy with mega doses of intravenous methylprednisolone, given at a dosage of 1 g/day for 5 days. ( 2 The TNF-a inhibitors such especially Rituximab are currently being investigated for efficacy in the treatment of Pemphigus Vulgaris).