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The usual total daily dose is 200 mg to 400 mg in two divided doses. Some patients may require doses up to 800 mg per day which is the maximum dose. It is recommended that therapy be initiated at a low dose, followed by titration to an effective dose.
In my practice, some patients prefer TMP-SMX DS thrice weekly to decrease the daily pill burden, whereas others prefer the routine of daily dosing. In HIV-infected children, the TMP-SMX chemoprophylaxis dose is 150/750 mg/m2 per day (approximately 5/25 mg/kg per day), up to a maximum dose of 320/1600 mg per day.