Fentanyl is in a class of drugs called opioid analgesics, which work by binding to nervous system proteins called opioid receptors, thereby blocking the transmission of pain signals to the brain.Duragesic is a transdermal (through-the-skin) patch.entanyl skin patches are only used to treat people who are tolerant (used to the effects of the medication) to narcotic pain medications. Fentanyl is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.
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