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The Biochemical Reactions. 1  DNA replication begins with the unzipping of the parent molecule as the hydrogen bonds between the base pairs are broken. 2  Once exposed, the sequence of bases on each of the separated strands serves as a template to guide the insertion of a complementary set of bases on the strand being synthesized.
As we go through this, remember, all that is happening is the DNA is being unzipped and each side of the zipper is being copied. The first step in DNA replication is to separate or unzip the two strands of the double helix. The enzyme in charge of this is called a helicase (because it unwinds the helix). The point where the double helix is opened up and the DNA is copied is called a replication fork.