-methyl transferase. Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines.
British Burn Washington, D.C. In 1814, as part of the War of 1812, the British planned to attack the U.S. city of Baltimore, an important city on the Chesapeake Bay. Near Baltimore was Washington, D.C., the nationâs capital since 1800.
Illustration of the Burning of Washington, DC, in 1814 during the War of 1812. Only thirteen years after the Presidents' House was completed, disaster struck. The War of 1812 brought invading British armies who set the house afire.The White House, along with the Capitol, was destroyed by 1814.