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Low platelet count is also a side effect of disease-modifying drugs, including methotrexate and biologics. Aspirin or other NSAIDs can affect blood clotting, and corticosteroid use causes the capillaries to become fragile and more likely to break and cause a bruise if you bump into something.
This should go away with time. Another possible side effect is nausea and vomiting. Your doctor should be informed if any of the side effects are bothersome. Methotrexate can cause mild liver irritation. Please tell you doctor if you have a history of any alcohol abuse, hepatitis, yellow jaundice, or liver disease.While on methotrexate you must limit yourself to 2 alcoholic beverages per week.ethotrexate is taken ONCE A WEEK. The pills are 2.5mg. each and the usual dose is 3 to 10 pills. The pills are taken together as a single dose on the same day each week (for example-every Friday). Follow your doctorâs directions. Do not take more or less medicine than ordered.