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The Man from U.N.C.L.E. filming took place in WB's Leavesden Studios outside of London, England, with location filming also in Italy, in Rome and Naples. Production began in early September and wrapped in early December 2013.
It was shot and released in the same year. Uncle Buck began filming, was released in theaters, and was released on home video all within 1989. It was changed to the Chicago area because unusually warm weather in Missouri that year forced the production to move to a more wintry climate.