When DNA replication starts, one primer is needed at the start of the leading strand. The lagging strand will need new primers regularly, and they mark the start of the stretches known as Okazaki fragments.
The recommended dose of Alimta is 500 mg/m2 administered as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle. The recommended dose of cisplatin is 75 mg/m2 infused over 2 hours beginning approximately 30 minutes after the end of Alimta administration. See cisplatin package insert for more information.
1 Antiemetic: This drug may be administered prophylactically 1â3 hr prior to chemotherapy and repeated every 2â4 hr after chemotherapy up to 4â6 doses daily. 2  Most patients respond to 5 mg three or four times daily. 3  Appetite Stimulant: Give 2. 5 mg twice daily before lunch and supper initially.