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Underlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.6  hypothyroidism.nderlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.
Another common cause of nausea is motion sickness. Lying down when the nausea begins often helps people who have motion sickness. If you're motion sick, try to breathe fresh air (i.e., via an opened window), and avoid reading or any activity that forces you to focus on something closely while in motion.