An opportunistic infection is an infection that occurs more frequently or is more severe in people with weakened immune systemsâsuch as those infected with HIVâthan in people with healthy immune systems. Acyclovir can also be used âoff-labelâ to prevent and treat other opportunistic infections of HIV infection. âOff-labelâ use refers to use of an FDA-approved medicine in a manner different from that described on the medicine label.
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