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believe the answer you're looking for has to do with the pressure-altitude-voltage derating related to corona discharge, which increases (gets worse) with higher altitude and peaks at around 80-100,000' Typically this is considered to occur at votlages above 300 V peak, but be sure you are accounting for all transients and internal voltages.
Assorted References. 1  discharge (in river: Worldâs largest rivers) 2  effects of proposed dam project (in lake (physical feature): Basins formed by wind action, animal activity, and meteorites) 3  freezing and flooding (in North America: Rivers) 4  Native American prehistory migration routes (in Native American: Prehistory)