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Low platelet count is also a side effect of disease-modifying drugs, including methotrexate and biologics. Aspirin or other NSAIDs can affect blood clotting, and corticosteroid use causes the capillaries to become fragile and more likely to break and cause a bruise if you bump into something.
26 Jan 2013. Nabumetone is an NSAID and they slow clotting time, so there is a danger of bleeding. Methotrexate can decrease your ability to fight infection. Long term it can effect your liver, and this in turn could make you bleed more, but that's not an immediate effect. Votes: +0.