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Clostridium difficile is a gram-positive, anaerobic, spore-forming bacillus that is responsible for the development of antibiotic-associated diarrhea and colitis. C difficile infection (CDI) commonly manifests as mild to moderate diarrhea, occasionally with abdominal cramping.
1 C. difficile causes colitis by producing toxins that damage the lining of the colon. 2  The symptoms of C. difficile colitis are fever, diarrhea, and abdominal pain.  Serious complications of C. difficile colitis include dehydration, rupture of the colon, and spread of infection to the abdominal cavity or body.