When DNA replication starts, one primer is needed at the start of the leading strand. The lagging strand will need new primers regularly, and they mark the start of the stretches known as Okazaki fragments.
The recommended dose of Alimta is 500 mg/m2 administered as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle. The recommended dose of cisplatin is 75 mg/m2 infused over 2 hours beginning approximately 30 minutes after the end of Alimta administration. See cisplatin package insert for more information.
1 Nonsquamous non-small cell lung cancer. 2  This cancer is a disease in which malignant (cancer) cells form in the tissues of the lung. 3  If you are having initial treatment for your lung cancer, ALIMTA may be given alone or in combination with another chemotherapy drug. If this is the first time you have been treated for your lung cancer, ALIMTA may be given with another anti-cancer drug called cisplatin. 2  If you have completed initial treatment for your lung cancer, ALIMTA may be given alone immediately following your initial treatment.