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Low platelet count is also a side effect of disease-modifying drugs, including methotrexate and biologics. Aspirin or other NSAIDs can affect blood clotting, and corticosteroid use causes the capillaries to become fragile and more likely to break and cause a bruise if you bump into something.
Why It Is Used. Methotrexate reduces inflammation caused by rheumatoid arthritis. It is the most common DMARD used to treat rheumatoid arthritis. Methotrexate may be used: 1  In the early stages of rheumatoid arthritis to prevent disease progression. 2  In combination with other medicines such as other DMARDs.all your doctor if you have: 1  Hives. 2  Signs of an infection, such as a sore throat, fever, sneezing, or coughing. 3  Bloody vomit. 4  Signs of unusual bleeding or bruising, such as black and tarry stools or blood in the urine. 5  Diarrhea. 6  Stomach pain.