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Low platelet count is also a side effect of disease-modifying drugs, including methotrexate and biologics. Aspirin or other NSAIDs can affect blood clotting, and corticosteroid use causes the capillaries to become fragile and more likely to break and cause a bruise if you bump into something.
Side effects do occur in some people taking methotrexate. At the low weekly doses used to treat rheumatoid arthritis, however, serious side effects are rare. The most common side effects include upset stomach, nausea, vomiting, loss of appetite, diarrhea, or mouth sores. If these develop, you should contact your doctor immediately.