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Blackouts can also be caused by a variety of drugs and other substances including: Alcohol intoxication. Medication side effects, such as the side effects of cancer treatments or seizure medications, or agents used for anesthesia. Poisons, such as cleaning chemicals or pesticides.
Blacking Out, Fainting, or Loss of Consciousness. Getting Started. Welcome. The two main reasons for blacking out are insufficient blood flow to the brain and abnormal electrical activity within the brain (a seizure). While both of these sound scary, in reality most episodes of blacking out are not related to life threatening health problems.