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Low platelet count is also a side effect of disease-modifying drugs, including methotrexate and biologics. Aspirin or other NSAIDs can affect blood clotting, and corticosteroid use causes the capillaries to become fragile and more likely to break and cause a bruise if you bump into something.
Stop using methotrexate and call your doctor at once if you have: 1  dry cough, shortness of breath; 2  diarrhea, vomiting, white patches or sores inside your mouth or on your lips; 3  blood in your urine or stools; 4  swelling, rapid weight gain, little or no urinating; 5  seizure (convulsions); 6  fever, chills, body aches, flu symptoms;