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Underlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.6  hypothyroidism.nderlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.
Medicines can cause nausea as a side-effect: 1  Some medicines, when taken in normal doses, may cause nausea - for example: 2  Strong painkillers such as codeine and morphine. 3  Antibiotics. Some antidepressants.  Medicines used to treat cancer (chemotherapy).