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believe the answer you're looking for has to do with the pressure-altitude-voltage derating related to corona discharge, which increases (gets worse) with higher altitude and peaks at around 80-100,000' Typically this is considered to occur at votlages above 300 V peak, but be sure you are accounting for all transients and internal voltages.
Chronic Effects on Humans: The substance is toxic to lungs, the nervous system. Other Toxic Effects on Humans: Very hazardous in case of inhalation. Hazardous in case of skin contact (irritant), of ingestion. Special Remarks on Toxicity to Animals: Not available. Special Remarks on Chronic Effects on Humans: Not available.