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Clostridium difficile is a gram-positive, anaerobic, spore-forming bacillus that is responsible for the development of antibiotic-associated diarrhea and colitis. C difficile infection (CDI) commonly manifests as mild to moderate diarrhea, occasionally with abdominal cramping.
Severe C. diff disease is another matter. It starts with profuse watery diarrhea and abdominal pain. Patients often have fever, nausea, and dehydration. There may be a little blood in the stool, but very bloody stool is rare. These symptoms usually signal colitis, a serious bowel infection.