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Mutagenicity is a specific term that refers to a permanent, heritable change in the structure or amount of genetic material of an organism and includes gene mutations as well as structural and numerical alterations in chromosomes (Eastmond et al.
A Mutation occurs when a DNA gene is damaged or changed in such a way as to alter the genetic message carried by that gene. A Mutagen is an agent of substance that can bring about a permanent alteration to the physical composition of a DNA gene such that the genetic message is changed. Once the gene has been damaged or changed the mRNA transcribed from that gene will now carry an altered message. The polypeptide made by translating the altered mRNA will now contain a different sequence of amino acids.