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Underlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.6  hypothyroidism.nderlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.
Constant mild nausea can stem from physical trauma such as brain injury or concussion or from meningitis, an infection in the lining of the brain. Nausea also can be a side effect of medications. Cancer treatments such as chemotherapy may cause constant mild nausea and a frequent urge to vomit. This term is misleading, though, since nausea can strike at any time throughout the day and may or may not be accompanied by vomiting.