-methyl transferase. Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines.
British Burn Washington, D.C. In 1814, as part of the War of 1812, the British planned to attack the U.S. city of Baltimore, an important city on the Chesapeake Bay. Near Baltimore was Washington, D.C., the nationâs capital since 1800.
On the other hand, Washington DC, also referred to as Washington District, is the capital of the US. The Residence Act, signed on the 16th of July in 1790, approved the creation of a district that was to be the capital. It was located along the River Potomac on the East Coast of the country.