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Clostridium difficile is a gram-positive, anaerobic, spore-forming bacillus that is responsible for the development of antibiotic-associated diarrhea and colitis. C difficile infection (CDI) commonly manifests as mild to moderate diarrhea, occasionally with abdominal cramping.
Symptoms of a more severe C. diff. infection include: 1  Frequent, watery diarrhea (up to 15 times each day) 2  Severe abdominal pain or tenderness. 3  Loss of appetite.  Low-grade fever of up to 101Â°F in children or 100Â°F to 102Â°F in 1  adults. Blood or pus in the stool.