2. R EGIONAL S ETTING The Mumbai Metropolitan Region extends over an area of 4355 sq. km and comprises Municipal Corporations of Greater Mumbai, Thane, Kalyan, Navi Mumbai and Ulhasnagar; 15 municipal towns; 7 non-municipal urban centers; and 995 villages.. R EGIONAL S ETTING The Mumbai Metropolitan Region extends over an area of 4355 sq. km and comprises Municipal Corporations of Greater Mumbai, Thane, Kalyan, Navi Mumbai and Ulhasnagar; 15 municipal towns; 7 non-municipal urban centers; and 995 villages.
PROPHASE: During the prophase the nucleoli in the nucleus disappear. The chromatin fibers become tightly ccoiled and condense into chromosomes. Chromosomes line up in pairs and are joined at the centromere. In the cytoplasm, the spindle fibers begin to form and are made of microtubules. The centrosomes move away from each other, propelled by the lengthening microtubules, or spindle fibers, between them.
Many other investigators, using a variety of experimental methods, have provided evidence to support the idea of a chromatin condensation cycle [3], [4] and [5]. It is possible to view the interphase chromatin in âas-near-to-chromosomeâ clarity by the induction of âpremature chromosome condensationâ (PCC) [6]. By the phenomenon known as âprophasingâ [7], it is possible to induce interphase DNA condensation and compaction in any nucleated cell by a variety of means.