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Underlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.6  hypothyroidism.nderlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.
The most common causes of nausea are intense pain â usually from an injury or illness â and the first trimester of pregnancy. There are also a number of other relatively common causes, including: 1  motion sickness.  emotional stress.