NSWC Port Hueneme Division is a field activity of Naval Sea Systems Command and provides the United States Navy global fleet with weapon system in-service engineering, logistics, and test and evaluation.
A missense mutation is when the change of a single base pair causes the substitution of a different amino acid in the resulting protein.This amino acid substitution may have no effect, or it may render the protein nonfunctional. single base pair substitution that results in the translation of a different amino acid at that position. Definition from: GeneReviews from the University of Washington and the National Center for Biotechnology Information.
The nonsense mutation converts a codon (a triplet of bases) that encodes an amino acid into a stop codon, one that specifies the termination of translation. There are three nonsense codons (UAG, UAA, and UGA) in mRNA. One of them comes normally at the end of each polypeptide. A nonsense codon is a stop codon which is out of place. Catching such a defective messenger RNA (mRNA) before a truncated and potentially harmful protein is synthesized is the job of what is called the nonsense-mediated mRNA decay (NMD) pathway.