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Low platelet count is also a side effect of disease-modifying drugs, including methotrexate and biologics. Aspirin or other NSAIDs can affect blood clotting, and corticosteroid use causes the capillaries to become fragile and more likely to break and cause a bruise if you bump into something.
processing.... CME Information. June 10, 2008 â Patients with rheumatoid arthritis (RA) treated with methotrexate are at an increased risk for melanoma, non-Hodgkin's lymphoma, and lung cancer, according to the results of a study reported in the June 15 issue of Arthritis Care & Research.he goal of this study was to determine cancer risk in all patients with RA who started taking methotrexate before June 1986 and who were attending 1 of 6 rheumatology practices (n = 459).