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How long do the effects last? In mild cases, diarrhea may last up to 14 days after you stop taking the antibiotic. If you have a more severe case, the symptoms may not go away until several weeks after you begin treatment. Sometimes the symptoms return in spite of treatment.
Antibiotics can sometimes cause diarrhea that is not due to C. difficile infection. The reason for the diarrhea is not clear. The practical implication is that not all diarrhea associated with antibiotics should be considered to be due to C. difficile and treated as such.