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The usual total daily dose is 200 mg to 400 mg in two divided doses. Some patients may require doses up to 800 mg per day which is the maximum dose. It is recommended that therapy be initiated at a low dose, followed by titration to an effective dose.
TOPAMAXÂ® is indicated for: Migraine. Adults and adolescents 12 years of age and older for the prophylaxis of migraine headache. The usefulness of TOPAMAXÂ® in the acute treatment of migraine headache has not been studied. Monotherapy Epilepsy. Initial monotherapy in patients 2 years of age and older with partial onset or primary generalized tonic-clonic seizures.