-methyl transferase. Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines.
British Burn Washington, D.C. In 1814, as part of the War of 1812, the British planned to attack the U.S. city of Baltimore, an important city on the Chesapeake Bay. Near Baltimore was Washington, D.C., the nationâs capital since 1800.
Immediately after the fire, Congress met for one session in Blodget's Hotel, which was at Seventh and E Streets, N.W. From 1815 to 1819, Congress occupied a building erected for it on First Street, N.E., on part of the site now occupied by the Supreme Court Building. This building later came to be known as the Old Brick Capitol. Latrobe returned to Washington in 1815, when he was rehired to restore the U.S. Capitol Building.