When DNA replication starts, one primer is needed at the start of the leading strand. The lagging strand will need new primers regularly, and they mark the start of the stretches known as Okazaki fragments.
The recommended dose of Alimta is 500 mg/m2 administered as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle. The recommended dose of cisplatin is 75 mg/m2 infused over 2 hours beginning approximately 30 minutes after the end of Alimta administration. See cisplatin package insert for more information.
âInstruct patients to initiate folic acid 400 mcg to 1000 mcg orally once daily beginning 7 days before the first dose of Alimta. Continue folic acid during the full course of therapy and for 21 days after the last dose of Alimta [see Warnings and Precautions (5.1)]. âAdminister vitamin B12 1 mg intramuscularly 1 week prior to the first dose of Alimta and every 3 cycles thereafter. Subsequent vitamin B12 injections may be given the same day as treatment with Alimta [see Warnings and Precautions (5.1)].