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The usual total daily dose is 200 mg to 400 mg in two divided doses. Some patients may require doses up to 800 mg per day which is the maximum dose. It is recommended that therapy be initiated at a low dose, followed by titration to an effective dose.
The mean dose of topiramate was 195 mg/day (range, 100â375 mg/day). All patients lost a substantial amount of weight on topiramate. The average weight loss was 22 lb (10 kg; range, 8â56 lb [4â25 kg]). No patient discontinued topiramate because of side effects.