The duration of analgesia is approximately three to six hours when methadone therapy is initiated, and this duration typically extends to eight to 12 hours with repeated dosing. In a study of cancer patients, an average of 2.4 doses per day was required to maintain adequate pain control.he duration of analgesia is approximately three to six hours when methadone therapy is initiated, and this duration typically extends to eight to 12 hours with repeated dosing. In a study of cancer patients, an average of 2.4 doses per day was required to maintain adequate pain control.
Britney Spears loses custody of her children. David Batty and agencies. Friday 4 January 2008 18.52 EST First published on Friday 4 January 2008 18.52 EST. A US judge has awarded sole custody of Britney Spears' two children to ex-husband Kevin Federline and suspended the singer's visitation rights.
Jaycee Dugard canât sue government for allegedly failing to prevent kidnapping. Jaycee Dugard (r.), who was abducted as a child and held for 18 years, and her mother, Terry Probyn, appear with their Hope Award at the National Center for Missing and Exploited Children annual Hope Awards in Washington. (Cliff Owen/AP)