The duration of analgesia is approximately three to six hours when methadone therapy is initiated, and this duration typically extends to eight to 12 hours with repeated dosing. In a study of cancer patients, an average of 2.4 doses per day was required to maintain adequate pain control.he duration of analgesia is approximately three to six hours when methadone therapy is initiated, and this duration typically extends to eight to 12 hours with repeated dosing. In a study of cancer patients, an average of 2.4 doses per day was required to maintain adequate pain control.
Britney Spears loses custody of her children. David Batty and agencies. Friday 4 January 2008 18.52 EST First published on Friday 4 January 2008 18.52 EST. A US judge has awarded sole custody of Britney Spears' two children to ex-husband Kevin Federline and suspended the singer's visitation rights.
Jamie Lynn Spears. This is the latest accepted revision, reviewed on 12 April 2017. Jamie Lynn Spears (born April 4, 1991) is an American actress, singer and songwriter. The younger sister of recording artist Britney Spears, she is known for her role as Zoey Brooks on the Nickelodeon teen sitcom Zoey 101, on which she starred from 2005 to 2008.