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Underlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.6  hypothyroidism.nderlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.
Medications That Cause Tiredness. Fatigue can be a side effect of some prescription medications. Find out which medications are most likely to cause tiredness and what can you do to diminish this problem. Many illnesses and chronic conditions require taking prescription medications. These can have a variety of side effects, including fatigue.