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Underlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.6  hypothyroidism.nderlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.
Examples of conditions that can cause loss of appetite and nausea include: 1  grief. 2  anxiety. 3  stress. stomach acid reflux.  food 1  poisoning. morning sickness.  motion sickness or 1  seasickness. food allergies or intolerances.  migraine 1  headaches. pain from a chronic or acute condition.