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Low platelet count is also a side effect of disease-modifying drugs, including methotrexate and biologics. Aspirin or other NSAIDs can affect blood clotting, and corticosteroid use causes the capillaries to become fragile and more likely to break and cause a bruise if you bump into something.
ps-chest pain is ALWAYS a worry on methotrexate and you MUST report this at your monitoring session, just in case it is your lungs. I get arthritic type pain in my ribs, but mtx can damage the lungs, and sometimes it can do this quickly-please make sure you tell your doc.ain started at about 2am and has progressively gotten worse. The pain is in all of the usual areas (Hips, Shoulder) but also there is new pain in Lower Legs, Lower Back, Left side Chest and upper back.