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believe the answer you're looking for has to do with the pressure-altitude-voltage derating related to corona discharge, which increases (gets worse) with higher altitude and peaks at around 80-100,000' Typically this is considered to occur at votlages above 300 V peak, but be sure you are accounting for all transients and internal voltages.
Clinical effects of nerve agents depend on the route and amount of exposure. The effect of inhalational exposure to nerve agent vapor in turn depends on the vapor concentration and the time of exposure. Exposure to low concentrations of nerve agent vapor produces immediate ocular symptoms, rhinorrhea, and in some patients, dyspnea. These ocular effects are secondary to the localized absorption of GB vapor across the outermost layers of the eye, causing lacrimal gland stimulation (tearing), pupillary sphincter contraction (miosis), and ciliary body spasm (ocular pain).