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Low platelet count is also a side effect of disease-modifying drugs, including methotrexate and biologics. Aspirin or other NSAIDs can affect blood clotting, and corticosteroid use causes the capillaries to become fragile and more likely to break and cause a bruise if you bump into something.
Methotrexate | Side Effects. Methotrexate is a very commonly used medication to treat rheumatic diseases such as rheumatoid arthritis. It is generally a very safe medication that is tolerated by most patients who take it.ne of the very rare but serious side effects of methotrexate is an unusual lung reaction. In some people, methotrexate can cause âinflammationâ in the lung tissue. The patient usually develops a dry cough (in the absence of a cold) or unexplained shortness of breath.