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prostate specific antigen, PSA (noun). a protein manufactured exclusively by the prostate gland; PSA is produced for the ejaculate where it liquifies the semen and allows sperm cells to swim freely; elevated levels of PSA in blood serum are associated with benign prostatic hyperplasia and prostate cancer.see more on Definitions.net Â». protein manufactured exclusively by the prostate gland; PSA is produced for the ejaculate where it liquifies the semen and allows sperm cells to swim freely; elevated levels of PSA in blood serum are associated with benign prostatic hyperplasia and prostate cancer. see more on Definitions.net Â».
A prostate-specific antigen (PSA) test measures the amount of prostate-specific antigen in the blood. PSA is released into a man's blood by his prostate gland. Healthy men have low amounts of PSA in the blood.The amount of PSA in the blood normally increases as a man's prostate enlarges with age. When combined with a digital rectal exam, the prostate-specific antigen (PSA) test may increase the chance of finding prostate cancer. 2  To learn more, see the topic Digital Rectal Examination (DRE) . 3  A PSA level within the normal ranges does not mean that prostate cancer is not present.