For phenomenology, the central feature of experience is a structure called intentionality, which correlates all things experienced with the mode of experience to which the experience is referenced. 2001, Lois Bloom, Erin Tinker, Ellin Kofsky Scholnick, The Intentionality Model and Language Acquisition, page 10,
PAM(Protospacer adjacent motif) sequence in a CRISPR is a 2-6 base pair DNA sequence immediately following the DNA sequence targeted by the Cas9 nuclease in the CRISPR bacterial adaptive immune system. PAM is a component of the invading virus or plasmid, but is not a component of the bacterial CRISPR locus. Cas9 will not successfully bind to or cleave the target DNA sequence if it is not followed by the PAM sequence.
CRISPR is a molecular tool that edits the genomes of cells and organisms. The technology uses the DNA-cutting enzyme Cas9, with the help of a guide RNA sequence, to find and modify genetic targets. Previously, researchers used a Cas9 endonuclease, an enzyme that cuts through both strands of DNA.