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A fever is often the first sign of hand-foot-and-mouth disease, followed by a sore throat and sometimes a poor appetite and malaise. One or two days after the fever begins, painful sores may develop in the mouth or throat.
Children with hand-foot-mouth disease usually start to feel crummy 3 to 7 days after they were exposed. Often, the first thing parents notice is their childrenâs decreased appetite for solids. Children may also have a fever and a sore throat. A day or two later, many children develop sores in the mouth.imilar-sounding âfoot-and-mouth diseaseâ is a disease of cattle and is not related to this condition. Hand-foot-mouth disease is usually caused by a virus called coxsackievirus A16. However, many children with coxsackievirus A16 infections do not have all of the features of hand-foot-mouth disease.