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A fever is often the first sign of hand-foot-and-mouth disease, followed by a sore throat and sometimes a poor appetite and malaise. One or two days after the fever begins, painful sores may develop in the mouth or throat.
Later symptoms of hand, foot and mouth disease. Later symptoms of the condition include (1-8): After the initial day or two of the infection many children develop red spots in the mouth that progress to ulcers. These worsen and are present in the mouth, tongue, tonsils, over gums and insides of the cheeks and throat.