When DNA replication starts, one primer is needed at the start of the leading strand. The lagging strand will need new primers regularly, and they mark the start of the stretches known as Okazaki fragments.
The recommended dose of Alimta is 500 mg/m2 administered as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle. The recommended dose of cisplatin is 75 mg/m2 infused over 2 hours beginning approximately 30 minutes after the end of Alimta administration. See cisplatin package insert for more information.
You may need additional doses up to three times a day during treatment or for a few days after treatment of cancer. 1  For chemotherapy, a typical adult dose of Zofran can range from 16 to 24 mg daily.  For radiation therapy, a typical adult dose of Zofran is 24 mg daily.