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Clostridium difficile is a gram-positive, anaerobic, spore-forming bacillus that is responsible for the development of antibiotic-associated diarrhea and colitis. C difficile infection (CDI) commonly manifests as mild to moderate diarrhea, occasionally with abdominal cramping.
Symptoms of mild cases include watery diarrhea, three or more times a day for several days, with abdominal pain or tenderness. Symptoms of more severe C. diff infection include: 1  Watery diarrhea, up to 15 times each day. 2  Severe abdominal pain.3  Loss of appetite.hat is the spleen and what causes an enlarged spleen (splenomegaly)? The spleen sits under your rib cage in the upper left part of your abdomen toward your back. It is an organ that is part of the lymph system and works as a drainage network that defends your body against infection.