Early cases of BXO can appear similar to those of candidal balanitis or to those of one of the various penile dermatoses, such as vitiligo, scleroderma, or erythroplasia of Queyrat. Although physical findings can suggest BXO, cutaneous biopsy and histology are needed to make a definitive diagnosis (Figure 4).
The Apennines form the backbone of the country running down the full length of the Italian peninsula from the Cadibona Pass to the tip of Calabria, continuing onto the island of Sicily. The range is about 2,000 kilometres long.
Reaching a height of 3,404 metres (11,168 ft) altitude at the peak of Aneto, the range separates the Iberian Peninsula from the rest of continental Europe, and extends for about 491 km (305 mi) from the Bay of Biscay to the Mediterranean Sea (Cap de Creus).