When DNA replication starts, one primer is needed at the start of the leading strand. The lagging strand will need new primers regularly, and they mark the start of the stretches known as Okazaki fragments.
The recommended dose of Alimta is 500 mg/m2 administered as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle. The recommended dose of cisplatin is 75 mg/m2 infused over 2 hours beginning approximately 30 minutes after the end of Alimta administration. See cisplatin package insert for more information.
Usual Adult Dose for Helicobacter pylori Infection. Dual therapy: 40 mg orally once a day, taken concomitantly with clarithromycin. -Duration of therapy: 14 days. Triple therapy: 20 mg orally 2 times a day, taken concomitantly with amoxicillin and clarithromycin. -Duration of therapy: 10 days. Comments: -Patients presenting with an ulcer at the time of treatment should continue treatment with a 20 mg dose orally once a day for 14 days (dual therapy) or 18 days (triple therapy).