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The Biochemical Reactions. 1  DNA replication begins with the unzipping of the parent molecule as the hydrogen bonds between the base pairs are broken. 2  Once exposed, the sequence of bases on each of the separated strands serves as a template to guide the insertion of a complementary set of bases on the strand being synthesized.
helicase-the enzyme-unzips the two strands of a dna molecule at the hydrogen bonds between the paired nitrogen bases what is the first step of dna replication and what enzyme is involved in this step dna polymerase