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From Wikipedia, the free encyclopedia. Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.
Secretion of HCl during the gastric phase is also regulated by a negative feedback mechanism. As the pH of gastric juice drops, so does the secretion of gastrinâat a pH of 2.5, gastrin secretion is reduced, and at a pH of 1.0 gastrin secretion ceases. The secretion of HCl thus declines accordingly.