The duration of analgesia is approximately three to six hours when methadone therapy is initiated, and this duration typically extends to eight to 12 hours with repeated dosing. In a study of cancer patients, an average of 2.4 doses per day was required to maintain adequate pain control.he duration of analgesia is approximately three to six hours when methadone therapy is initiated, and this duration typically extends to eight to 12 hours with repeated dosing. In a study of cancer patients, an average of 2.4 doses per day was required to maintain adequate pain control.
Britney Spears loses custody of her children. David Batty and agencies. Friday 4 January 2008 18.52 EST First published on Friday 4 January 2008 18.52 EST. A US judge has awarded sole custody of Britney Spears' two children to ex-husband Kevin Federline and suspended the singer's visitation rights.
Jamie Lynn Spears will appear with her family and costumed 'chocolate' labrador retriever in the Mardi Paws parade on Feb. 22, 2015. In advance of the event, she spoke about her music career, love for her home state of Louisiana, her family, including sister Britney Spears, and a recent incident that made headlines. For country singer Jamie Lynn Spears, there's no other place she'd rather be than home.