Always check your withholding with this tool if there are personal or financial changes in your life that might change your tax liability, for example new employment or a promotion changing income amount, or new family members altering the number of dependents you claim.
believe the answer you're looking for has to do with the pressure-altitude-voltage derating related to corona discharge, which increases (gets worse) with higher altitude and peaks at around 80-100,000' Typically this is considered to occur at votlages above 300 V peak, but be sure you are accounting for all transients and internal voltages.
Long-term exposure to polluted air can have permanent health effects such as: Accelerated aging of the lungs. Loss of lung capacity and decreased lung function. Development of diseases such as asthma, bronchitis, emphysema, and possibly cancer.