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From Wikipedia, the free encyclopedia. Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.
When gastrin binds to its receptor, the parietal cell's permeability to calcium ions (Ca++) is altered so that the ions move into the cell. The intracellular increase in Ca++ activates the intracellular protein phosphokinases.