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Underlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.6  hypothyroidism.nderlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.
1 Other causes of headache and nausea can include elevated blood pressure, cancer, head injury, Crohn's disease, drug or medication interactions and side effects, pregnancy, infections, cardiac problems, depression and diabetes.