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Clostridium difficile is a gram-positive, anaerobic, spore-forming bacillus that is responsible for the development of antibiotic-associated diarrhea and colitis. C difficile infection (CDI) commonly manifests as mild to moderate diarrhea, occasionally with abdominal cramping.
http://www.gastro.org/attachments/6401/1_CDiff_Overview_Design.pdf. 1  Clostridium difficile, or C. diff for short, is an infection from a bacterium, or bug, that can grow in your intestines and cause bad GI symptoms.  The main risk of getting C. diff infection is antibiotic use.