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Underlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.6  hypothyroidism.nderlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.
1. This type of anemia can be a cause of nausea and fatigue. Achrestic anemia is very similar to pernicious anemia that is caused by the deficiency in vitamin B12. This lowers the ability of your body to produce enough red blood cells. This lowers the amount of oxygen that circulates in your body.ancer and Chemotherapy. Nausea and fatigue can be caused by cancer. You can experience these two symptoms before, after, and during the chemotherapy sessions. When you have cancer, you already have bad cells taking over your body and these destroy your healthy cells.