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After observing the response to initial therapy with Voltaren (diclofenac sodium) , the dose and frequency should be adjusted to suit an individual patient's needs. For the relief of osteoarthritis, the recommended dosage is 100-150 mg/day in divided doses (50 mg b.i.d. or t.i.d., or 75 mg b.i.d.).
Diclofenac 150 mg/day was the most effective nonsteroidal anti-inflammatory drug (NSAID) for improving both pain and function in knee or hip osteoarthritis (OA), and acetaminophen (paracetamol) was least effective and should not be used in this setting, according to a new network meta-analysis published online March 17 in The Lancet.