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Underlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.6  hypothyroidism.nderlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.
Anemia , a lack of red blood cells, can cause fatigue, pale skin and gums, brittle nails, irritability, and more. Acute kidney failure is sudden and can cause swelling, frequent dark urination, fatigue, nausea and more. Anemia, a lack of red blood cells, can cause fatigue, pale skin, weakness, dizziness, headache and more. Anemia of chronic disease (ACD) can cause fatigue, pale skin, weakness, dizziness, headache and more. Labyrinthitis, an infection and swelling in the inner ear, and may cause vertigo or hearing loss.