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Low platelet count is also a side effect of disease-modifying drugs, including methotrexate and biologics. Aspirin or other NSAIDs can affect blood clotting, and corticosteroid use causes the capillaries to become fragile and more likely to break and cause a bruise if you bump into something.
Guide for Adult Patients Self Administering Methotrexate by. Injection at Home. This is a step-by-step guide to giving once weekly Methotrexate by. subcutaneous (under the skin) injection. Methotrexate belongs to a group of drugs known as cytotoxics (drugs that are used to. treat patients who have cancer). In rheumatology the drug is used in much smaller. doses to produce an anti- inflammatory effect. The process of teaching you how to give the injection will be a sequence of events.