Mechanism of action. Aminoglycosides like neomycin irreversibly bind to specific 30S-subunit proteins and 16S rRNA. Specifically neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit.This region interacts with the wobble base in the anticodon of tRNA.pecifically neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA.
Inflammation of the surface of the eye (conjunctivitis) and inflammation of the eyelids (blepharitis) are common causes of swollen eyes. Other common causes include crying, lack of sleep, or excessive rubbing of the eyes. Wearing contact lenses can also result in eye swelling. Depending on the cause, swelling may occur in one or both eyes, and it may be accompanied by redness, pain, itching, excessive tear production, or other types of discharge from the affected eyes.
These fluids become trapped in surrounding tissues, causing edema. Puffy, swollen eyelids and dark circles under the eyes can occur when you have an eye infection such as pink eye. These swollen eyes are caused by inflammation associated with the eye infection, which directly affects the neighboring eyelids. Also, dry eyes can cause general puffiness and swelling.