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Underlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.6  hypothyroidism.nderlying medical conditions that can lead to nausea and fatigue include: 1  acute liver failure. 2  cancer. 3  chronic kidney disease. 4  food allergies. 5  hyperthyroidism.
Loss of appetite can accompany fatigue if you feel nauseated. Certain medications can have this effect. Fatigue and loss of appetite can be the result of medical treatments, especially cancer treatments. Medications that can cause fatigue and loss of appetite include: 1  sleeping pills.  antibiotics.