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Clostridium difficile is a gram-positive, anaerobic, spore-forming bacillus that is responsible for the development of antibiotic-associated diarrhea and colitis. C difficile infection (CDI) commonly manifests as mild to moderate diarrhea, occasionally with abdominal cramping.
Patients with severe C. difficile colitis may have: 1  a high fever of 102 F to 104 F (39 C to 40 C), 2  severe diarrhea (more than 10 watery stools a day) with blood, and. 3  severe abdominal pain and tenderness.