-methyl transferase. Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines.
British Burn Washington, D.C. In 1814, as part of the War of 1812, the British planned to attack the U.S. city of Baltimore, an important city on the Chesapeake Bay. Near Baltimore was Washington, D.C., the nationâs capital since 1800.
Washington DC is the capital city of the United States of America (USA). D.C. stands for the District of Columbia which is the federal district containing the city of Washington. The city is named for George Washington, military leader of the American Revolution and the first President of the United States.he District of Columbia and the city of Washington are coextensive and are governed by a single municipal government, so for most practical purposes they are considered to be the same entity. It is known locally as the District or simply D.C. Historically, it was called the Federal City.