-methyl transferase. Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines.
British Burn Washington, D.C. In 1814, as part of the War of 1812, the British planned to attack the U.S. city of Baltimore, an important city on the Chesapeake Bay. Near Baltimore was Washington, D.C., the nationâs capital since 1800.
Redirected from The Capitol Building. 18,749 pages on this wiki. Before the Great War, the United States Capitol building housed the legislative branch of the government of the United States. It is located in Washington, D.C. , on top of Capitol Hill at the east end of the the Mall.The other side of the Capitol opens onto Seward Square.he Capitol Building entrance from the west, in The Mall, exits into the Capitol Building west entrance area. The Seward Square entrance from the east is one of two doors into the Capitol Building west entrance.