When DNA replication starts, one primer is needed at the start of the leading strand. The lagging strand will need new primers regularly, and they mark the start of the stretches known as Okazaki fragments.
The recommended dose of Alimta is 500 mg/m2 administered as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle. The recommended dose of cisplatin is 75 mg/m2 infused over 2 hours beginning approximately 30 minutes after the end of Alimta administration. See cisplatin package insert for more information.
Nomethylphenidate ER (ConcertaÂ®)â¡ADHD 13 to 17 years old Patients naive to methylphenidate: Initial dose: 18 mg once a day; Maximum dose: 72 mg once a day Patients taking methylphenidate: dosing is based on current dosage and clinical judgmentMay increase daily dose by 18 mg at weekly intervals.