When DNA replication starts, one primer is needed at the start of the leading strand. The lagging strand will need new primers regularly, and they mark the start of the stretches known as Okazaki fragments.
The recommended dose of Alimta is 500 mg/m2 administered as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle. The recommended dose of cisplatin is 75 mg/m2 infused over 2 hours beginning approximately 30 minutes after the end of Alimta administration. See cisplatin package insert for more information.
The daily dose may be administered once a day (or in equallydivided doses every 12 hours). The usual duration of therapy is 7 to 14days. Adults: The usual adult daily dose is 1 to 2 grams given once a day (or in equallydivided doses twice a day) depending on the type and severity of infec-tion.