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Clostridium difficile is a gram-positive, anaerobic, spore-forming bacillus that is responsible for the development of antibiotic-associated diarrhea and colitis. C difficile infection (CDI) commonly manifests as mild to moderate diarrhea, occasionally with abdominal cramping.
Clostridium difficile (â C. difficile â or â C. diff â) is a type of spore-forming bacteria that produces two types of toxins.The main clinical symptoms of C. difficile infection (CDI) are watery diarrhea, fever, nausea, abdominal pain/tenderness, and loss of appetite.More serious conditions can also result such as pseudomembranous colitis (inflammation of the colon), perforations of the colon, and sepsis.he main clinical symptoms of C. difficile infection (CDI) are watery diarrhea, fever, nausea, abdominal pain/tenderness, and loss of appetite.