Definition. Phenylketonuria (PKU) can be defined as a rare metabolic disorder caused by a deficiency in the production of the hepatic (liver) enzyme phenylalanine hydroxylase (PAH).bbr. PKU A genetic disorder in which the body lacks the enzyme necessary to metabolize phenylalanine to tyrosine. Left untreated, the disorder can cause brain damage and progressive mental retardation as a result of the accumulation of phenylalanine and its breakdown products.
OAHU FUN FACTS. 1) Oahu is 44 miles long, 30 miles wide, 112 miles around and is the third-largest island in the Hawaiian chain of 132 islets, atolls and reefs stretching from kure atoll in the northwest to the big island of Hawaii in the southeast. 2) Honolulu is the largest city in the world.
The Big Island of Hawaii has 4,028 square miles of land mass and itâs growing. The entire state of Hawaii has 6,422 square miles in total. The Big Islandâs 4,028 square miles represents almost 63% of the stateâs total land mass. So the Big Island is bigger than all the other island combined. The Big Island is even bigger than the states of Rhode Island and Delaware combined.