1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
Memory Loss From Long Term Brain Damage. Long-term brain damage from alcohol use is, surprisingly, often a side effect of liver damage from alcohol use. The liver is supposed to clear alcohol from the system and safely dispose of it through urination. However, when overused, the liver ceases to function as efficiently.