1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
The Long-Term Effects of Alcohol on the Body. Long-term addiction can take a heavy toll on the entire body. Alcohol can impact the heart and cause cardiomyopathy, arrhythmias (Irregular heart beat), stroke and high blood pressure. The liver takes the brunt with repercussions including fatty liver, alcoholic hepatitis, fibrosis and cirrhosis.