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Weight gain and increase in appetite â Sometimes if you are also taking an immunosuppressive, the appetite might be decreased. Your metabolism is how you burn fat. As you age, your metabolism tends to slow down. Prednisone can have a negative effect on metabolism.oss of muscle mass â Exercise is very important for keeping muscle mass. While on prednisone, try to exercise within your own range. Men have a better chance of building up their muscles after the age of 50 than woman do because of testosterone, but exercise can help woman as well.
New Reply New Topic Follow. prednisone face swelling. I have been on prednisone for a few months now, the swelling of the face is freaking me out along with the weight gain. what can i do to help the swelling of the face.Loading... Blinkies1241711. Hey I think I might know what the problem is.hat I have found to be helpful is to use combo medications with less side effects so that the Pred can be lowered as much as your body can handle. I was on 40 mg's then 20 and now thank God I am on 10 a day...1/2 in the AM & half in the PM.