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Nortriptyline is an active metabolite of Amitriptyline. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.ortriptyline is an active metabolite of Amitriptyline. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.
M6G is the most potent morphine metabolite, and its analgesic activity is achieved through direct interaction with opioid receptors. M3G metabolite is characterized by complex pharmacologic activities including partial antagonism of morphine-induced analgesia.