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Weight gain and increase in appetite â Sometimes if you are also taking an immunosuppressive, the appetite might be decreased. Your metabolism is how you burn fat. As you age, your metabolism tends to slow down. Prednisone can have a negative effect on metabolism.oss of muscle mass â Exercise is very important for keeping muscle mass. While on prednisone, try to exercise within your own range. Men have a better chance of building up their muscles after the age of 50 than woman do because of testosterone, but exercise can help woman as well.
Doctors and patients have to make an informed decision by considering the disadvantages of prednisone against its advantages. It cannot be ignored that prednisone is a life-saving drug, and it is never prescribed unless the patient absolutely needs it.mproper dosage of prednisone, or wrong way of taking and stopping prednisone, can lead to several side effects. Prednisone Side Effects. Prednisone Withdrawal. While considering benefits and risks of prednisone, one cannot ignore the process of prednisone withdrawal. Prednisone treatment cannot be stopped abruptly.