Speciï¬cally, the sva package contains functions. for the identifying and building surrogate variables for. high-dimensional data sets. Surrogate variables are covariates. constructed directly from high-dimensional data (like gene. expression/RNA sequencing/methylation/brain imaging data) that. can be used in subsequent analyses to adjust for unknown, unmodeled, or latent sources of noise. The sva package can be.
Princess of Wales Diana Biography. Lady Diana Frances Spencer married Prince Charles (1948â) in 1981 and became Princess of Wales. Retaining her title and her popularity after the royal couple divorced in 1996, Diana continued her charitable work. She died in a tragic car accident in 1997.
BBC footage from the wedding of Prince Charles and Lady Diana. In less than a year the couple produced their first child, William, on 21 June 1982. A second son, Prince Harry, was born on 15 September 1984. By that time Prince Charles' long-running relationship with Camilla Parker-Bowles was putting strain on his marriage. Princess Diana's relationship with the rest of the Royal Family deteriorated and she developed bulimia. The couple separated in 1993.