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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Whether it's once a night or over and over, popping awake to use the bathroom disrupts your sleep cycle and cuts into your restful REM sleep. The best solution for this problem, officially called nocturia, is prevention. If you don't wake up in the first place, you won't lose those precious zzz's.