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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Our original intention had been to conduct a study. that induced sleep fragmentation in normal sleepers and then. evaluate changes in daytime function. However, it was unclear. from the literature at the time how much sleep fragmentation was. necessary to cause significant changes in the restorative function. of the sleep. The best available examples of sleep fragmentation. arose from the study of the sleep of patients with OSA. But in. these patients, apneas might cause very transient EEG arousals, longer EEG arousals associated with a change in sleep stage, or. even awakenings 16 seconds to several minutes in duration.