1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
Areas of the body affected by alcoholism. Drinking excessive amounts of alcohol can seriously harm your health, damaging the liver, kidneys, heart, brain and central nervous system. We already discussed long-term damage to the brain. Over time, alcohol can inflict serious damage on other body parts as well. Liver: The liver is particularly vulnerable to the effects of alcohol because it is the organ in which alcohol and other toxins are metabolized (broken down into less harmful substances to be removed from the body).