Definition. Phenylketonuria (PKU) can be defined as a rare metabolic disorder caused by a deficiency in the production of the hepatic (liver) enzyme phenylalanine hydroxylase (PAH).bbr. PKU A genetic disorder in which the body lacks the enzyme necessary to metabolize phenylalanine to tyrosine. Left untreated, the disorder can cause brain damage and progressive mental retardation as a result of the accumulation of phenylalanine and its breakdown products.
OAHU FUN FACTS. 1) Oahu is 44 miles long, 30 miles wide, 112 miles around and is the third-largest island in the Hawaiian chain of 132 islets, atolls and reefs stretching from kure atoll in the northwest to the big island of Hawaii in the southeast. 2) Honolulu is the largest city in the world.
NiÊ»ihau or Niihau (/ËniËhaÊ/ ; Hawaiian : [ËniÊiËhau]) is the westernmost and seventh largest of the inhabited Hawaiian Islands in the U.S. state of HawaiÊ»i, lying 17.5 miles (15.2 nmi; 28.2 km) southwest of KauaÊ»i across the Kaulakahi Channel and having an area of 69.5 square miles (180 km 2).i Ê» ihau is located about 18 miles (29 km) west of KauaÊ»i, and the tiny, uninhabited island of Lehua lies 0.7 miles (0.61 nmi; 1.1 km) north of Ni Ê» ihau. Ni Ê» ihau's dimensions are 6.2 miles by 18.6 miles (10 km x 30 km).