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Nortriptyline is an active metabolite of Amitriptyline. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.ortriptyline is an active metabolite of Amitriptyline. Therapeutic drug levels are monitored to assist the physician assessing therapeutic response and to avoid toxicity.
PROMETHEUS Â® Thiopurine Metabolites testing assists physicians in optimizing ongoing dosing of thiopurine. immunosuppressant therapy to reach and maintain therapeutic goal. Thiopurine metabolite testing also helps to. identify drug metabolite levels that may lead to toxicity and some of the reasons for treatment failure. â¢ A quantitative evaluation of 6-TGN (thioguanine nucleotide) and 6-MMPN (methyl mercaptopurine. nucleotide)