How to Respond to an Epidemic. Imagine an epidemic so virulent that it is the leading cause of death for children, teens, young adults. It takes 125,000 lives in America alone every year, not to mention causing nearly $80 billion in medical costs.
The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated. This can either involve the replication of DNA in living organisms such as prokaryotes and eukaryotes, or that of DNA or RNA in viruses, such as double-stranded RNA viruses.
In theory, this abundance of potential replication origins in each replication unit or replicon might favor the activation of at least one origin per replicon (Karschau et al. 2012). This low usage of replication origins results from a flexible choice of replication origins in each cell . Thus, within a given cell population, each cell has the potential to activate a large number of origins (100,000 in mouse fibroblasts) and might use a different cohort of origins in an apparent stochastic manner.