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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
The people who suffer from nocturia which is also classed as excessive urination at night time have to wake up to urinate at night. Always waking up through the night causes many of these people to have a disturbed sleep pattern. Some of the causes for this disruptive condition are: Constant infections of the urinary tract.