Definition. Phenylketonuria (PKU) can be defined as a rare metabolic disorder caused by a deficiency in the production of the hepatic (liver) enzyme phenylalanine hydroxylase (PAH).bbr. PKU A genetic disorder in which the body lacks the enzyme necessary to metabolize phenylalanine to tyrosine. Left untreated, the disorder can cause brain damage and progressive mental retardation as a result of the accumulation of phenylalanine and its breakdown products.
OAHU FUN FACTS. 1) Oahu is 44 miles long, 30 miles wide, 112 miles around and is the third-largest island in the Hawaiian chain of 132 islets, atolls and reefs stretching from kure atoll in the northwest to the big island of Hawaii in the southeast. 2) Honolulu is the largest city in the world.
Along with the rest of the Hawaiian Islands, Oahu is one of the largest and northernmost islands of Polynesia. In the greatest dimension, this volcanic island is 44 miles (71 km) long and 30 miles (48 km) across. The length of the shoreline is 227 miles (365 km). The island is the result of two separate shield volcanoes: WaiÊ»anae and KoÊ»olau, with a broad valley or saddle (the central OÊ»ahu Plain) between them. The highest point is KaÊ»ala in the WaiÊ»anae Range, rising to 4,003 feet (1,220 m) above sea level.