The resulting mRNA is a single-stranded copy of the gene, which next must be translated into a protein molecule. During translation, which is the second major step in gene expression, the mRNA is read according to the genetic code, which relates the DNA sequence to the amino acid sequence in proteins (Figure 2).
This group of drugs followed and largely superseded another group of medications with similar effects, but a different mode of action, called H2-receptor antagonists. PPIs are among the most widely sold drugs in the world, and the first one, omeprazole, is on the WHO Model List of Essential Medicines.
Proton pump inhibitors (PPIs) are usually taken one time a day. They are sometimes taken two times a day if a stronger dose is needed. Proton pump inhibitors (PPIs) greatly reduce the amount of acid produced by the stomach, which in turn reduces irritation of the stomach lining and allows an ulcer to heal. When used with antibiotics, PPIs also help treat Helicobacter pylori (H. pylori) infection. Proton pump inhibitors are used to treat ulcers.