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GABA is made in brain cells from glutamate and works by blocking nerve impulses. Glutamate fires the nerve impulses and GABA does the opposite by telling the nerves not to fire. In the case of GABA deficiency, nerve cells fire too often and too easily.hat is where GABA comes in. Gamma-Amino Butyric acid (GABA) is an amino acid which acts as a neurotransmitter in the central nervous system.
GABA is the primary inhibitory neurotransmitter in the brain and therefore filters out irrelevant messages (static) by terminating signals from the excitatory neurotransmitters: glutamate, and its positive modulators epinephrine, norepinephrine, and PEA.auses of GABA deficiency. GABA receptor function may be reduced because of a genetic polymorphism in the GABA receptor that reduces the efficiency of GABA neurotransmission, the presence of GABA receptor inhibitors, or low serotonin levels. Serotonin is a positive regulator of GABA-GABA receptor interaction.