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Fibrous Pericardium. Continuous with the central tendon of the diaphragm, the fibrous pericardium is made of tough connective tissue and is relatively non-distensible. This rigidity prevents rapid overfilling of the heart, but can have several serious clinical consequences (see cardiac tamponade).
The myocardium is the heartâs thick middle layer. It is made almost entirely of cardiac muscle tissue and blood vessels, and the inside of it is covered with the endocardium. This thick heart layer makes up the majority of the wall of the heart.