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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
Our circadian rhythm (or âbody clockâ) is influenced by melatonin, as it acts as a âtime cueâ, anticipating sleep. It is also an important physiological regulator of the sleep-wake cycle. Melatonin is not a sedative, but a sign of darkness or night-time, and is a cue for innate night-time behaviour.In the morning when plasma levels of melatonin decrease, sleep ends and wakefulness begins.elatonin â A signal of darkness and marker for circadian rhythms. Melatonin is a naturally occurring hormone that is key to sleep and the sleep-wake cycle in humans and animals.