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Posts. 148. elguapo, It comes with that warning because diphenhydramine, the active ingredient in Unisom, can make urination more difficult. A guy with an enlarged prostate is already going to have difficulty urinating and diphenhydramine would just add to the problem.
A lot happens in your body while you sleep. When you get your ZZZs, you cycle between REM and non-REM sleep. REM stands for rapid eye movement. During REM sleep, your eyes move quickly in different directions. That doesn't happen during non-REM sleep.