How to Respond to an Epidemic. Imagine an epidemic so virulent that it is the leading cause of death for children, teens, young adults. It takes 125,000 lives in America alone every year, not to mention causing nearly $80 billion in medical costs.
The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated. This can either involve the replication of DNA in living organisms such as prokaryotes and eukaryotes, or that of DNA or RNA in viruses, such as double-stranded RNA viruses.
Consideration of the influence of chromosome structure on DNA replication in bacteria and eukaryotes must also take into account the dif-ferent organization of DNA in the cell. The bacterial chromosome is as-sociated with the cell membrane but otherwise is exposed to the entire in-tracellular environment.In contrast, eukaryotic DNA replication occurs in a distinct compartment in the cell, affording the separation of proteins that may influence the initiation of DNA replication.ukaryotes have devised a DNA polymerase switching mechanism that involves the pol-a:primase complex in priming DNA replication at the origin of DNA replication and for every Okazaki fragment, and then a second DNA polymerase that is not associated with the primase (pol-6 or E) completing the synthesis (Figs.