Definition. Phenylketonuria (PKU) can be defined as a rare metabolic disorder caused by a deficiency in the production of the hepatic (liver) enzyme phenylalanine hydroxylase (PAH).bbr. PKU A genetic disorder in which the body lacks the enzyme necessary to metabolize phenylalanine to tyrosine. Left untreated, the disorder can cause brain damage and progressive mental retardation as a result of the accumulation of phenylalanine and its breakdown products.
OAHU FUN FACTS. 1) Oahu is 44 miles long, 30 miles wide, 112 miles around and is the third-largest island in the Hawaiian chain of 132 islets, atolls and reefs stretching from kure atoll in the northwest to the big island of Hawaii in the southeast. 2) Honolulu is the largest city in the world.
Hawaii is the 43rd largest of the 50 states in the USA ahead of Rhode Island, Delaware, Connecticut, New Jersey, New Hampshire, Vermont and Massachusetts. Hawaii's total land area is 6,422.63 square miles (16,634.53 kmÂ²). Hawaii's total coastline is 750 miles (1,207 km).id you know that Hawaii is the most remote island chain in the world? In fact, the Hawaiian archipelago is located in the Central Pacific Ocean, 2,390 miles (3,850 km) from California and 3,850 miles (6,195 km) from Japan.