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Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates.oagulase is tightly bound to the surface of the bacterium S. aureus and can coat its surface with fibrin upon contact with blood. The fibrin clot may protect the bacterium from phagocytosis and isolate it from other defenses of the host.
Blood coagulation is a process that converts specific circulating elements of the blood system into a gel with insoluble characteristics; preventing loss of blood from injured blood vessels, tissues or organs. The process is made up of two systems. The first system is around a course that involves the formation of thrombus, a blood clot, through a complicated sequence involving a cellular system made up of platelets. The platelets normally circulate in the blood for they are mainly involved in the formation of plug over damaged blood vessels.