1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
How does alcohol affect the brain and the rest of the body? Alcohol adversely affects the brain, the liver, the kidneys, the heart, the blood vessels, the lining of the stomach, and various hormonal and regulatory systems. Even the word intoxicated indicates alcohol's true nature - a toxic substance.