Definition. Phenylketonuria (PKU) can be defined as a rare metabolic disorder caused by a deficiency in the production of the hepatic (liver) enzyme phenylalanine hydroxylase (PAH).bbr. PKU A genetic disorder in which the body lacks the enzyme necessary to metabolize phenylalanine to tyrosine. Left untreated, the disorder can cause brain damage and progressive mental retardation as a result of the accumulation of phenylalanine and its breakdown products.
OAHU FUN FACTS. 1) Oahu is 44 miles long, 30 miles wide, 112 miles around and is the third-largest island in the Hawaiian chain of 132 islets, atolls and reefs stretching from kure atoll in the northwest to the big island of Hawaii in the southeast. 2) Honolulu is the largest city in the world.
Hawaii -- also known as the Big Island -- is not only the largest of the Hawaiian islands, it is also the largest island in the United States. The Big Island is 4,028 square miles and is the third most visited by tourists each year. When visiting the Big Island, you'll want to see the Maunaloa volcanoes, Kau desert, Puna Fern Forest, Hawaii Volcanoes National Park and Kealakekua Bay. Maui is 727 square miles, making it the second largest island.