1 In January of 1857 the first performances of The Frozen Deep are given. Dickens plays the role of Richard Wardour. This play gives Dickens the idea for A Tale of Two Cities.  In August of 1857 Dickens meets Ellen Ternan, an actress hired to act in benefit performances of The Frozen Deep.
If you overload your liver (drink too much at one time), the excess alcohol will end up circulating in your bloodstream affecting your brain, heart and other tissues resulting in you becoming increasingly intoxicated.
Binge Drinking May Quickly Lead to Liver Damage. UCSF Study in Mice Finds Fatty Liver, Inflammation, Enzyme Changes within Seven Weeks. Alcohol consumed during just seven weeks of intermittent binge drinking harms the liver in ways that more moderate daily drinking does not, according to researchers at UC San Francisco. The scientists discovered that just 21 binge drinking sessions in mice were enough to cause symptoms of early-stage liver disease.