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About mood stabilizers. Mood stabilizers are medications used to regulate fluctuations in mood. They are primarily used to treat bipolar disorder, a psychiatric illness in which a patient experiences extreme swings in mood, ranging from mania to depression.This class of medications consists of lithium and certain anticonvulsant medications.ypes and differences of mood stabilizers. Lithium was the first mood stabilizer approved for the treatment of bipolar disorder and it is often used for mania. According to the National Mental Health Association (NMHA), it is effective in controlling mania in 60 percent of patients with this condition.