Qualitative and quantitative factor deficiencies can affect the function of the coagulation pathways. Factor V and factor II (prothrombin) mutations are examples of qualitative deficiencies and are the most common inherited predisposing factors for blood clots.
Definition. A comma splice is a run on sentence, where two or more independent clauses are 'spliced' or split by a comma. A comma splice is considered a significant English error.
Click here to see a 239-word sentence that is a perfectly fine sentence (structurally). When two independent clauses are connected by only a comma, they constitute a run-on sentence that is called a comma-splice. The example just above (about the sunscreen) is a comma-splice.