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The dosage range for cephalexin (KeflexÂ®) is most often 22 to 33 mg/kg. Great Danes are big dogs as you know (weight range can be 110 to 160 pounds). Let's say your dog weighs a modest 110 pounds. They would be roughly 55 kg. 55 kg x 22 mg/kg = 1210 mg or if they used the 33 mg/kg = 1815 mg.
1 Cephalexin, also known by the brand names KeflexÂ® and RilexineÂ®, is an antibiotic used for dogs and cats. 2  Cephalexin belongs to the cephalosporin class of drugs and iis related to the penicillin drugs in how it kills bacteria. cephalosporins have a much broader range of activity against bacteria than penicillins. The usual dose of cephalexin for dogs and cats is 10 to 15 mg per pound (22 to 30 mg/kg) every 8 to 12 hours orally. 2  Reduced dosages are recommended for pets with kidney failure. 3  Should be administered with food if cephalexin causes nausea or vomiting in your pet.