Qualitative and quantitative factor deficiencies can affect the function of the coagulation pathways. Factor V and factor II (prothrombin) mutations are examples of qualitative deficiencies and are the most common inherited predisposing factors for blood clots.
Definition. A comma splice is a run on sentence, where two or more independent clauses are 'spliced' or split by a comma. A comma splice is considered a significant English error.
Remember that the comma splice uses a comma to tie a sentence together--without a coordinating conjunction. This type of run-on sentence does the opposite by using the coordinating conjunction but leaving out the comma.