Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
The enormous population of 23.5 million (23,500,000) is also due to the fact that Karachi is the main business center of, almost, all the corporations in Pakistan. Having population density of 6,663/km2, it is also a main hub of higher education in Muslim world. See Also; 10 Most Dangerous Cities in The World.
Lahore is ranked as a Gamma+ world city, and is one of Pakistan's wealthiest cities with an estimated total nominal GDP of $58.14 billion. Lahore is the historic cultural centre of the Punjab region, and is the largest Punjabi city in the world. The city has a long history, and was once under the rule of the Hindu Shahis, Ghaznavids, Ghurids, Lodis, Marathas and the Delhi Sultanate.