Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
The enormous population of 23.5 million (23,500,000) is also due to the fact that Karachi is the main business center of, almost, all the corporations in Pakistan. Having population density of 6,663/km2, it is also a main hub of higher education in Muslim world. See Also; 10 Most Dangerous Cities in The World.
This means Karachi is by far more dense than any other megacity with an urban population of more than 10 million except Dhaka, Bangladesh and Mumbai. This makes Karachi the third largest city in the world and the largest in Pakistan. Karachi was previously the capital of Pakistan until Islamabad was constructed.