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Crohn's disease is caused by a combination of environmental, immune and bacterial factors in genetically susceptible individuals. It results in a chronic inflammatory disorder, in which the body's immune system attacks the gastrointestinal tract possibly directed at microbial antigens.
Crohn's disease is an inflammatory bowel disease in which inflammation injures the intestines. It is a long-term (chronic) condition. Crohn's disease typically begins between ages 15 and 40. No one knows for sure what triggers the initial intestinal inflammation at the start of Crohn's disease.