Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
Pakistan's 2nd most populous city, Lahore, is only about half the size, with just 6.3 million people, but is still the world's 15th most populous city. Pakistan has six additional cities that have passed the one million population mark.
The irrigated portions of the plain are densely populated, being the site of many of Pakistan's principal cities, including Lahore, Faisalabad (formerly Lyallpur), Hyderabad, and Multan. Karachi, the nation's chief port, is located west of the irrigated land at a site accessible to oceangoing vessels.