Qualitative and quantitative factor deficiencies can affect the function of the coagulation pathways. Factor V and factor II (prothrombin) mutations are examples of qualitative deficiencies and are the most common inherited predisposing factors for blood clots.
Definition. A comma splice is a run on sentence, where two or more independent clauses are 'spliced' or split by a comma. A comma splice is considered a significant English error.
In order to better understand run-on sentences and comma splices, it is important to review the basics of writing a grammatically correct simple sentence: A sentence can be complete and correct with one basic independent clause made up of one subject plus its corresponding predicate.