There eventually is enlargement of the lymph nodes, liver, and spleen. Common to all leukemias are the tendency to bleed and the resultant anemia and increased susceptibility to infection. The diagnosis of leukemia requires confirmation of leukemic cells in the bone marrow by bone marrow biopsy and aspiration.
River Phoenix's autopsy showed deadly levels of cocaine and morphine (heroin shows up as morphine, as it's metabolized by the body), Valium, marijuana and ephedrine. Ephedrine is the main ingredient found in crystal meth. Official cause of death was Acute multiple drug ingestion. River Phoenix was just 23 years old.
River Phoenix was born River Jude Bottom in Madras, Oregon. His mother, Arlyn (Dunetz), a Bronx-born secretary, and his father, John Bottom, a carpenter, met in California in 1968. They worked as itinerant fruit pickers, and later joined the Children of God religious group (John was originally Catholic, while Arlyn was born Jewish).