Examples of APPLICATION. 1  Our loan application has been approved. 2  Anyone interested in running for office must file an application by August 1st. 3  If you'd like to be considered for the job, please send us a letter of application that gives your experience and qualifications.xamples of APPLICATION. 1  Our loan application has been approved. 2  Anyone interested in running for office must file an application by August 1st. 3  If you'd like to be considered for the job, please send us a letter of application that gives your experience and qualifications.
brain reward pathways The most important reward pathway in brain is the mesolimbic dopamine system. This circuit (VTA-NAc) is a key detector of a rewarding stimulus. Under normal conditions, the circuit controls an individual's responses to natural rewards, such as food, sex, and social interactions, and is therefore an important determinant of motivation and incentive drive.
The Biochemistry of Addiction. Dopamine plays an important role in the reward system. Dopamine is a natural chemical in the brain that sends signals to the limbic system. When introduced into the limbic system, drugs either mimic dopamine or cause an overproduction of it in the brain. The reason normal actions that activate the brain reward system (food, drinking, sex, music, etc.) donât reprogram the brain for addiction is because they produce normal levels of dopamine.