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The dosage range for cephalexin (KeflexÂ®) is most often 22 to 33 mg/kg. Great Danes are big dogs as you know (weight range can be 110 to 160 pounds). Let's say your dog weighs a modest 110 pounds. They would be roughly 55 kg. 55 kg x 22 mg/kg = 1210 mg or if they used the 33 mg/kg = 1815 mg.
There are no known major side effects for melatonin when given to dogs. Even where melatonin has been given to dogs over an extended period there have not been many reports of adverse reactions. So to all intents and purposes melatonin is quite safe for dogs. That said, itâs not advisable to give melatonin to very young dogs. Nor should it be given to pregnant dogs.