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Crohn's disease is caused by a combination of environmental, immune and bacterial factors in genetically susceptible individuals. It results in a chronic inflammatory disorder, in which the body's immune system attacks the gastrointestinal tract possibly directed at microbial antigens.
Crohn's (or Crohn) disease is a disease that usually affects the small intestine and less commonly the colon, but it is capable of involving the remainder of the gastrointestinal tract-the mouth, esophagus, and stomach.he chronic inflammation that is the basis of Crohn's disease causes ulceration, swelling, and scarring of the parts of the intestine that it involves. Other names for Crohn's disease include granulomatous enteritis, regional enteritis, ileitis, and granulomatous colitis when it involves the colon.