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Crohn's disease is caused by a combination of environmental, immune and bacterial factors in genetically susceptible individuals. It results in a chronic inflammatory disorder, in which the body's immune system attacks the gastrointestinal tract possibly directed at microbial antigens.
Definition. Crohn's disease is characterized by recurring episodes of inflammation of any part of the gastrointestinal tract, from the mouth to the anus. This inflammation is transmural and can result in strictures, microperforations, and fistulae.efinition. Crohn's disease is characterized by recurring episodes of inflammation of any part of the gastrointestinal tract, from the mouth to the anus. This inflammation is transmural and can result in strictures, microperforations, and fistulae.