Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
Pakistan's 2nd most populous city, Lahore, is only about half the size, with just 6.3 million people, but is still the world's 15th most populous city. Pakistan has six additional cities that have passed the one million population mark.
Lahore is ranked as a Gamma+ world city, and is one of Pakistan's wealthiest cities with an estimated total nominal GDP of $58.14 billion. Lahore is the historic cultural centre of the Punjab region, and is the largest Punjabi city in the world. The city has a long history, and was once under the rule of the Hindu Shahis, Ghaznavids, Ghurids, Lodis, Marathas and the Delhi Sultanate.