Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
The enormous population of 23.5 million (23,500,000) is also due to the fact that Karachi is the main business center of, almost, all the corporations in Pakistan. Having population density of 6,663/km2, it is also a main hub of higher education in Muslim world. See Also; 10 Most Dangerous Cities in The World.
Hyderabad, twice the capital of Sindh and now the sixth largest city of Pakistan, is one of the oldest cities of the South Asia. Hyderabad is a communication centre, connected by rail with Peshawar and Karachi. The second largest city of the province of Sindh, it has over 6 million people dwelling in it.