Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
The enormous population of 23.5 million (23,500,000) is also due to the fact that Karachi is the main business center of, almost, all the corporations in Pakistan. Having population density of 6,663/km2, it is also a main hub of higher education in Muslim world. See Also; 10 Most Dangerous Cities in The World.
Pakistan is bordered by India on the east, the Arabian Sea on the south, Iran on the southwest, and Afghanistan on the west and north; in the northeast is the disputed territory (with India) of Kashmir, of which the part occupied by Pakistan borders on China. Islamabad is the capital and Karachi is the largest city.