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The dosage range for cephalexin (KeflexÂ®) is most often 22 to 33 mg/kg. Great Danes are big dogs as you know (weight range can be 110 to 160 pounds). Let's say your dog weighs a modest 110 pounds. They would be roughly 55 kg. 55 kg x 22 mg/kg = 1210 mg or if they used the 33 mg/kg = 1815 mg.
First, you would have to give your dog the vaccines for parvo and distemper. Once that is done, wait several weeks and then give them the vaccination for leptospirosis. Make sure this is not being given to a dog while there are other vaccinations being administered as well.