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CISSUS QUADRANGULARIS Side Effects & Safety. Some specific commercial products containing Cissus quadrangularis are POSSIBLY SAFE when taken by mouth appropriately short-term (for up to 6-8 weeks). These products can cause side effects such as headache, intestinal gas, dry mouth, diarrhea, and insomnia.ISSUS QUADRANGULARIS Side Effects & Safety. Some specific commercial products containing Cissus quadrangularis are POSSIBLY SAFE when taken by mouth appropriately short-term (for up to 6-8 weeks). These products can cause side effects such as headache, intestinal gas, dry mouth, diarrhea, and insomnia.
Cissus quadrangularis. Cissus quadrangularis is a traditional medicine for joint and bone health (as well as various feminine disorders and menopause), and shows promise in promoting bone growth rates. It is popular as a joint aid for athletes, with preliminary evidence supporting this property of cissus.