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Possible causes of bladder outlet obstruction might include: 1  Enlarged prostate, also known as benign prostatic hyperplasia (BPH) â this is the most common cause of bladder outlet obstruction in men. 2  Scarring of the urinary channel (urethra) or bladder neck, as a result of injury or surgery.
Over time, interstitial cystitis can cause physical damage to the bladder wall. Scarring and stiffening of the bladder wall may occur as a result of the chronic inflammation, leading to a decrease in bladder capacity. Glomerulations (areas of pinpoint bleeding) and petechial hemorrhage may be seen on the bladder wall.