Sawako Kuronuma (é»æ²¼ ç½å­ Kuronuma Sawako) is the main protagonist of the series Kimi ni Todoke.
When the intensity, duration, and/or frequency of anxiety become distressful and chronic, such that it interferes with a person's functioning, it is often referred to as pathological anxiety.Anxiety disorders represent variant forms of this pathological anxiety.hese three factors-duration, intensity, and frequency-distinguish normal, adaptive anxiety from abnormal, pathological anxiety. As such, abnormal anxiety is different from normal anxiety because it is disproportionate to the situation that elicited the anxious response.
1 Generally, those changes affect sex hormones, such as estrogen and testosterone, indicating that the two hormones may contribute to anxiety. 2  Studies on rates appear to confirm this belief. 3  Thyroid Hormone An overactive thyroid can also cause a significant problem with anxiety, and is very likely to cause panic attacks.ithout hormones, your body may not produce the right amount of neurotransmitters, and anxiety may be the result. That said, some examples of hormones that may contribute to anxiety include: 1  Stress Hormones (Cortisol) Cortisol and anxiety have a cyclical relationship.