Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
Pakistan's 2nd most populous city, Lahore, is only about half the size, with just 6.3 million people, but is still the world's 15th most populous city. Pakistan has six additional cities that have passed the one million population mark.
The climate of Karachi (Pakistan) Karachi is located in the southern part of Pakistan on the Arabian Sea in the province of Sindh of which it also is the capital. With a population of 20 million in the city itself and a population of 25 million in the urban areas Karachi is the largest city in Pakistan.