Inflammatory bowel disease (IBD) involves inflammation of the intestines and is a chronic (long-lasting) illness. The two major types of IBD are ulcerative colitis and Crohn's disease. Ulcerative colitis affects the lining of the large intestine (colon) and/or the rectum.
Definition of comb binding. : mechanical binding (as of pamphlets) in which split rings of plastic or metal are passed through slots at the gutter margin.
Wire-O and Spiral Binding. Both of these mechanical bindings hold far fewer pages than comb binding. Wire-O is a series of parallel wire loops attached along a wire, while spiral binding is a metal or plastic continuous loop passing through the punched holes in a spiral from the top to the bottom of the book.