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The dosage range for cephalexin (KeflexÂ®) is most often 22 to 33 mg/kg. Great Danes are big dogs as you know (weight range can be 110 to 160 pounds). Let's say your dog weighs a modest 110 pounds. They would be roughly 55 kg. 55 kg x 22 mg/kg = 1210 mg or if they used the 33 mg/kg = 1815 mg.
Cefazolin should not be given to pets that are currently being treated with other antibiotics unless prescribed by a vet. Dogs or cats that are sensitive to penicillin or other cephalosporin type antibiotics should not be given cefazolin, as they are likely sensitive to this drug as well.