Qualitative and quantitative factor deficiencies can affect the function of the coagulation pathways. Factor V and factor II (prothrombin) mutations are examples of qualitative deficiencies and are the most common inherited predisposing factors for blood clots.
Definition. A comma splice is a run on sentence, where two or more independent clauses are 'spliced' or split by a comma. A comma splice is considered a significant English error.
A run-on is a sentence in which two or more independent clauses (i.e., complete sentences) are joined without an appropriate punctuation or conjunction. For example: It is nearly half past five we cannot reach town before dark.