Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
The enormous population of 23.5 million (23,500,000) is also due to the fact that Karachi is the main business center of, almost, all the corporations in Pakistan. Having population density of 6,663/km2, it is also a main hub of higher education in Muslim world. See Also; 10 Most Dangerous Cities in The World.
As one of the most populous countries in the world, Pakistan is also home to some of the world's megacities. Its most populous city, Karachi, is not only the largest in Pakistan but is also the 7th most populous city in the world, boasting a population that exceeds 11 millon people.