Iatrogenic Cushing Syndrome. Author: Ha Cam Thuy Nguyen, MD; Chief Editor: Romesh Khardori, MD, PhD, FACP more... Background. Cushing syndrome, first described by Harvey in 1912, refers to signs and symptoms caused by excess free plasma glucocorticoids. Excess glucocorticoids can be from increased endogenous production or prolonged exposure to exogenous use of glucocorticoid products.
As is apparent from the above discussion, a drug target is a key molecule involved in a particular metabolic or signal transduction pathway that is specific to a disease condition or a specific disease. However, the term âdrug targetâ itself has several limitations and is debated within the pharmaceutical industry.n this respect, several points should be kept in mind. First, a drug target is a relative concept. For starters, a drug target is, just like other biomolecules, also a biomolecule involved in a transduction pathway. The difference between the two is only in their location and role in the transduction pathway.
Certain natural substances in the body, such as neurotransmitters and hormones, target specific receptors on the surface of cells. When these substances bind with the receptor on a cell, they stimulate that receptor to perform its function, which is to produce or to inhibit a specific action in the cell.Drugs can also target and bind with these receptors.he drugs then interact with cells or tissues where they produce their intended effects (target sites). This interaction is called selectivity. Selectivity is the degree to which a drug acts on a given site relative to other sites. Some drugs are relatively nonselective.