Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
Pakistan's 2nd most populous city, Lahore, is only about half the size, with just 6.3 million people, but is still the world's 15th most populous city. Pakistan has six additional cities that have passed the one million population mark.
In 2014, Karachi has an estimated population of more than 23.7 million, which makes it the third-largest city in the world by population within the city limits, the 7th largest urban agglomeration and the largest city in the Muslim world.