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The dosage range for cephalexin (KeflexÂ®) is most often 22 to 33 mg/kg. Great Danes are big dogs as you know (weight range can be 110 to 160 pounds). Let's say your dog weighs a modest 110 pounds. They would be roughly 55 kg. 55 kg x 22 mg/kg = 1210 mg or if they used the 33 mg/kg = 1815 mg.
As with all prescribed medicines, cephalexin should only be given to the dog/cat for which it was prescribed. It should be given only for the condition for which it was prescribed. Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.