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The dosage range for cephalexin (KeflexÂ®) is most often 22 to 33 mg/kg. Great Danes are big dogs as you know (weight range can be 110 to 160 pounds). Let's say your dog weighs a modest 110 pounds. They would be roughly 55 kg. 55 kg x 22 mg/kg = 1210 mg or if they used the 33 mg/kg = 1815 mg.
Dosage. A veterinarian will usually prescribe 10mg of cephalexin for each lb. of your dog's weight, with the dosage administered twice a day. Never give your dog more than one dose at a time or overdose may occur. Signs of overdose include pale gums, muscle spasms and weakness.