Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
The enormous population of 23.5 million (23,500,000) is also due to the fact that Karachi is the main business center of, almost, all the corporations in Pakistan. Having population density of 6,663/km2, it is also a main hub of higher education in Muslim world. See Also; 10 Most Dangerous Cities in The World.
Islamabad was built during the 1960s to replace Karachi as Pakistan's capital. The city's master-plan divides the city into eight zones, including administrative, diplomatic enclave, residential areas, educational sectors, industrial sectors, commercial areas, and rural and green areas.