Qualitative and quantitative factor deficiencies can affect the function of the coagulation pathways. Factor V and factor II (prothrombin) mutations are examples of qualitative deficiencies and are the most common inherited predisposing factors for blood clots.
Definition. A comma splice is a run on sentence, where two or more independent clauses are 'spliced' or split by a comma. A comma splice is considered a significant English error.
Both parts of the sentence are independent clauses, and commas should not be used to connect independent clauses if there is no coordinating conjunction. This mistake is known as a comma splice. Incorrect: I like cows, however, I hate the way they smell. Correct: I like cows; however, I hate the way they smell.