Aripiprazole is effective for the treatment of acute manic episodes of bipolar disorder in adults, children, and adolescents. Used as maintenance therapy, it is useful for the prevention of manic episodes, but is not useful for bipolar depression.
Pakistan's 2nd most populous city, Lahore, is only about half the size, with just 6.3 million people, but is still the world's 15th most populous city. Pakistan has six additional cities that have passed the one million population mark.
This means Karachi is by far more dense than any other megacity with an urban population of more than 10 million except Dhaka, Bangladesh and Mumbai. This makes Karachi the third largest city in the world and the largest in Pakistan. Karachi was previously the capital of Pakistan until Islamabad was constructed.