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There are four key causes of low creatinine: low muscle mass; liver problems; diet; pregnancy or illness; Low muscle mass. Levels of creatinine are often linked with muscle mass or the amount of muscle in the body, which can decrease with age or illness.
There are many reasons why creatinine levels may be low, some as relatively harmless as a low-protein diet and others as serious as advanced liver disease. Low creatinine alone does not generally indicate a serious medical condition and can be caused by multiple factors.