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C57BL/6, often referred to as C57 black 6, C57 or black 6 (standard abbreviation: B6), is a common inbred strain of laboratory mouse. It is the most widely used genetic background for genetically modified mice for use as models of human disease.They are the most widely used and best-selling mouse strain, due to the availability of congenic strains, easy breeding, and robustness.57BL/6 mice have a dark brown, nearly black coat. They are more sensitive to noise and odours and are more likely to bite than the more docile laboratory strains such as BALB/c. They are good breeders.