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There are four key causes of low creatinine: low muscle mass; liver problems; diet; pregnancy or illness; Low muscle mass. Levels of creatinine are often linked with muscle mass or the amount of muscle in the body, which can decrease with age or illness.
What are the Causes of Low Creatinine Level What are the Causes of Low Creatinine Level? Creatinine is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass).In chemical terms, creatinine is a spontaneously formed cyclic derivative of creatine.