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The dosage range for cephalexin (KeflexÂ®) is most often 22 to 33 mg/kg. Great Danes are big dogs as you know (weight range can be 110 to 160 pounds). Let's say your dog weighs a modest 110 pounds. They would be roughly 55 kg. 55 kg x 22 mg/kg = 1210 mg or if they used the 33 mg/kg = 1815 mg.
In some cases, many veterinarians may not prescribe cephalexin for a dog that has a urinary tract infection. Individuals could use the cephalexin for the infection with the 259 milligram dose. In most cases a urinary tract infection will go away in about 2 to 3 days after starting an antibiotic.