1 Place a fat-trimmed 3- to 3-1/2-pound fresh beef brisket in a 13x9x2-inch baking pan. 2  Pour the cooking liquid over the meat. 3  Cover the pan with foil. 4  Bake in a 325 degrees F oven about 3 hours or until tender, turning once halfway through cooking time. Season the brisket with ground black pepper. 2  Pour the sauce over the brisket. 3  Cover the slow cooker and cook on the low-heat setting for 12 to 14 hours. 4  Or cook on the high-heat setting for 6 to 7 hours.
The juxtaglomerular apparatus can be found within the kidneys. The juxtaglomerular apparatus helps to balance blood pressure. Glomeruli inside the kidney filter blood as part of the process of making urine.d. As blood volume rises, the juxtaglomerular apparatus reduces renin production. This keeps the blood pressure in balance. If there are errors with this system, blood pressure can get too high, or drop too low, depending on the nature of the problem.
Juxtaglomeruar Apparatus (JGA) consists of: 1) Juxtaglomerular cells (modified smooth muscle cells) of afferent arteriole including renin containing (synthesizes and stores renin) and sympathetically innervated granulated cells which function as mechanoreceptors to sense blood pressure.he macula densa senses the load and causes constriction of nearby afferent arteriole, increasing the resistance. This will return osmolality and filtrate flow rate to normal. Decreased renal arterial pressure leads to a decreased delivery of fluid (decreased osmolality or decreased flow rate) to the macula densa.