Neither of these things are guaranteed to happen if you get the flu vaccine when you are sick, but they are possibilities. If you have just a mild illness, there is no reason to wait to get vaccinated.
Early in the day, let roast stand at room temperature at least 1 hour before cooking. Preheat oven to 375 degrees. Rub meat ... the outside and rare in the middle. Meat will be very brown ... stand at room temperature for at least one hour.
1 Place the roast in the preheated oven. 2  Cook for 15 to 20 minutes (depends on size of roast) at 450 degrees F. 3  Then, without opening the oven door, turn the heat down to 325 degrees F. 4  Cook until meat thermometer inserted reaches about 140 degrees. Use a rack inside your baking pan, most come with one. 2  Place the roast in the preheated oven. 3  Cook for 15 to 20 minutes (depends on size of roast) at 450 degrees F. 4  Then, without opening the oven door, turn the heat down to 325 degrees F.