Calculate Your Hourly Equivalents. Instructions: Enter your annual salary, the number of hours you work per day, and the number of days you work per week, then click the Calculate Hourly Pay button. Mouse over the blue question marks for a further explanation of each entry field.alculate Your Hourly Equivalents. Instructions: Enter your annual salary, the number of hours you work per day, and the number of days you work per week, then click the Calculate Hourly Pay button. Mouse over the blue question marks for a further explanation of each entry field.
prions are infectious by. their effect on normal versions of protein. Sterilizing prions therefore involves the denaturation of the protein to a state where the molecule is no longer able to induce the abnormal folding of normal proteins.rion propagation/reproduction. by transmitting a mis-folded protein state; as with viruses the protein itself does not self-replicate, rather it induces existing polypeptides in the host organism to take on the rogue form.
Prion aggregates are extremely stable and accumulate in infected tissue, causing tissue damage and cell death. This structural stability means that prions are resistant to denaturation by chemical and physical agents, making disposal and containment of these particles difficult.hese refolded prions can then go on to convert more proteins themselves, leading to a chain reaction resulting in large amounts of the prion form. All known prions induce the formation of an amyloid fold, in which the protein polymerises into an aggregate consisting of tightly packed beta sheets.