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There are four key causes of low creatinine: low muscle mass; liver problems; diet; pregnancy or illness; Low muscle mass. Levels of creatinine are often linked with muscle mass or the amount of muscle in the body, which can decrease with age or illness.
Low Creatinine Level. Low levels of creatinine fall under .8 mg/dL. Low creatinine levels in the blood can indicate a possible muscular disease, such as muscular dystrophy. Low levels can also show the effects of aging or that something needs evaluation in a person's diet.