Qualitative and quantitative factor deficiencies can affect the function of the coagulation pathways. Factor V and factor II (prothrombin) mutations are examples of qualitative deficiencies and are the most common inherited predisposing factors for blood clots.
Definition. A comma splice is a run on sentence, where two or more independent clauses are 'spliced' or split by a comma. A comma splice is considered a significant English error.
In terms of grammar and composition, the sentence above is a comma splice because it has been incorrectly joined by a comma. As you can see, the first sentence, the students completed their classwork, is an independent clause. Similarly, the second sentence is an independent clause.