Qualitative and quantitative factor deficiencies can affect the function of the coagulation pathways. Factor V and factor II (prothrombin) mutations are examples of qualitative deficiencies and are the most common inherited predisposing factors for blood clots.
Definition. A comma splice is a run on sentence, where two or more independent clauses are 'spliced' or split by a comma. A comma splice is considered a significant English error.
1 The distinction between an impermissible comma splice and a legitimate juncture involving a comma is far less precise, for example, than that between a complete sentence and a fragment 2  .. (Anne Klinck, Coming to Terms: Unravelling the Comma Splice.. 3  The English Journal, March 1998).