Qualitative and quantitative factor deficiencies can affect the function of the coagulation pathways. Factor V and factor II (prothrombin) mutations are examples of qualitative deficiencies and are the most common inherited predisposing factors for blood clots.
Definition. A comma splice is a run on sentence, where two or more independent clauses are 'spliced' or split by a comma. A comma splice is considered a significant English error.
2. Use a comma after a dependent clause that starts a sentence. Example: When I went running, I saw a duck.. A dependent clause is a grammatical unit that contains both subject and verb but cannot stand on its own, like When I went running .... Commas always follow these clauses at the start of a sentence. If a dependent clause ends the sentence, however, it no longer requires a comma. Only use a comma to separate a dependent clause at the end of a sentence for added emphasis, usually when negation occurs.