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Penile Discharge Fact Sheet Save this for later. Table of Contents. Penile discharge is the abnormal loss of fluid that is not urine or semen from the urethra at the tip of the penis. It is commonly the sign of a sexually transmitted disease (STD), and requires prompt and accurate diagnosis and treatment.
If untreated, it can lead to penile ischemia and subsequent erectile dysfunction. 1  Peyronie's disease. 2  A benign (noncancerous) condition of the penis that tends to affect middle-aged men. It is characterized by the formation of plaques in the tunica albuginea of the penis and may cause erectile dysfunction.