Qualitative and quantitative factor deficiencies can affect the function of the coagulation pathways. Factor V and factor II (prothrombin) mutations are examples of qualitative deficiencies and are the most common inherited predisposing factors for blood clots.
Definition. A comma splice is a run on sentence, where two or more independent clauses are 'spliced' or split by a comma. A comma splice is considered a significant English error.
The Comma Splice. A comma splice, also called a run-on, occurs when a writer has connected two main clauses with a comma alone. A main clause makes a complete thought, so you should not find a wimpy comma struggling to join two such powerful clauses. Main Clause + , + Main Clause.