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The oversight committees, particularly the HPSCI, became increasingly alarmed over the role US intelligence agencies were playing in the implementation of the administration's Central American policy. The issue of greatest concern was the CIA's support to the Contra rebels in Nicaragua.
Two hallmarks of Salmonella pathogenesis, the host invasion and intracellular proliferation, are directly linked to genes in SPI. SPI-1 contains invasion genes; while SPI-2 is required for intracellular pathogenesis and has a crucial role for systemic S. enterica infections ( Hansen-Wester and Hensel 2001).