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Definition of gastrointestinal tract. medical. : the part of the digestive system that consists of the stomach and intestines.
Your gastrointestinal (GI) tract deals with the dirty work of your body: digesting food for nutrients and sending out the trash. This noisy, smelly, squishy system includes the esophagus, a 10 inch-long tube; the stomach, a fist-size bag of muscle; 20 feet of small intestine; and 6 feet of large intestine (aka the colon).