Qualitative and quantitative factor deficiencies can affect the function of the coagulation pathways. Factor V and factor II (prothrombin) mutations are examples of qualitative deficiencies and are the most common inherited predisposing factors for blood clots.
Definition. A comma splice is a run on sentence, where two or more independent clauses are 'spliced' or split by a comma. A comma splice is considered a significant English error.
See Commas with Compound Sentences for information about when that comma can be omitted.) What causes a comma splice is not the comma between the two clauses, but rather the absence of the coordinator in the attempt to join the clauses.