Examples of APPLICATION. 1  Our loan application has been approved. 2  Anyone interested in running for office must file an application by August 1st. 3  If you'd like to be considered for the job, please send us a letter of application that gives your experience and qualifications.xamples of APPLICATION. 1  Our loan application has been approved. 2  Anyone interested in running for office must file an application by August 1st. 3  If you'd like to be considered for the job, please send us a letter of application that gives your experience and qualifications.
brain reward pathways The most important reward pathway in brain is the mesolimbic dopamine system. This circuit (VTA-NAc) is a key detector of a rewarding stimulus. Under normal conditions, the circuit controls an individual's responses to natural rewards, such as food, sex, and social interactions, and is therefore an important determinant of motivation and incentive drive.
Serotonin (also called 5-HT) is a neurotransmitter that is produced from tryptophan. Although serotonin is only produced by a small number of neurons (1000's), each of those neurons innervates as many as 500,000 other neurons (3, 12).rolonged use of MDMA results in destruction of serotonergic neurons in the brain (4, 5). Because of the similarities between ecstasy 'trips' and LSD 'trips,' it can be concluded that they must activate a similar pathway, i.e. the serotonergic pathway. Several theories of the mechanism of LSD have been postulated.