Mechanism of Action. Levocetirizine, the active enantiomer of cetirizine, is an anti histamine; its principal effects are mediated via selective inhibition of H1 receptors. The antihistaminic activity of levocetirizine has been documented in a variety of animal and human models. In vitro binding studies revealed that levocetirizine has an affinity for the human H1-receptor 2-fold higher than that of cetirizine (Ki = 3 nmol/L vs. 6 nmol/L, respectively).
Backcountry Splitboarding in Oregon and Beyond! Bend Glacier. The Bend Glacier is the largest of Broken Topâs two named glaciers, and is located on the north/northeast side of the mountain. Itâs meltwater feeds the headwaters of Squaw Creek, which eventually empties into the Deschutes River.
At 76 km (47 mi) long, it is the longest glacier in the Karakoram and second-longest in the world's non-polar areas. It falls from an altitude of 5,753 m (18,875 ft) above sea level at its head at Indira Col on the China border down to 3,620 m (11,875 ft) at its terminus. Entire Siachen Glacier with all major passes is currently under administration of India since 1984, while Pakistan controls region west of Saltoro Ridge.