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Fifth disease is transmitted through respiratory droplets and contact with infected blood products. The incubation period (the time between the initial infection and the onset of symptoms) is usually between 4 and 21 days. People with fifth disease are most contagious before the onset of symptoms.ifth disease is transmitted through respiratory droplets and contact with infected blood products. The incubation period (the time between the initial infection and the onset of symptoms) is usually between 4 and 21 days. People with fifth disease are most contagious before the onset of symptoms.
Fifth disease is a mild illness caused by a virus called human parvovirus B19. The medical name for fifth disease is erythema infectiosum (EI). This infection occurs primarily in school-age children between 5 and 14 years of age during winter and spring.