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1,4-Dihydropyridine (DHP), an important class of calcium antagonist, inhibits the influx of extracellular Ca+2 through L-type voltage-dependent calcium channels. Three-dimensional (3D) structure of calcium channel as a receptor for 1,4-dihydropyridine is a step in understanding its mode of action. Protein structure prediction and modeling tools are becoming integral parts of the standard toolkit in biological and biomedical research.
The most commonly used structure for calcium specific binding is 1,2-bis(2-aminophenoxy)ethane-N,N,Nâ,Nâ-tetraacetic acid, (BAPTA) (Figure 1). The multiple anionic carboxyl groups bind the divalent calcium ion in a similar fashion as the calcium specific chelator, ethylene glycol bis(Î²-aminoethylether) (EGTA).