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Cetirizine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Cetirizine is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose. Cetirizine is also used to treat itching and swelling caused by chronic urticaria (hives). Cetirizine may also be used for purposes not listed in this medication guide.
Overview of Cetirizine (ZyrtecÂ®) for Dogs and Cats. 1  Cetirizine, commonly known by the brand name ZyrtecÂ®, is a type of anti-histamine commonly recommended for dogs with itching. It can also be used in cats.  Histamine is a chemical that is released in the body in response to inflammation or allergy.