Mechanism of Action. Levocetirizine, the active enantiomer of cetirizine, is an anti histamine; its principal effects are mediated via selective inhibition of H1 receptors. The antihistaminic activity of levocetirizine has been documented in a variety of animal and human models. In vitro binding studies revealed that levocetirizine has an affinity for the human H1-receptor 2-fold higher than that of cetirizine (Ki = 3 nmol/L vs. 6 nmol/L, respectively).
Glacier Calf That Broke Off Greenland's Jakobshavn Could Be Largest Ever. The Jakobshavn glacier-Greenland's fastest-moving glacier located near Ilulissat-is seen in a NASA image taken by the Operational Land Imager (OLI) on the Landsat 8 satellite August 16, 2015.
At 76 km (47 mi) long, it is the longest glacier in the Karakoram and second-longest in the world's non-polar areas. It falls from an altitude of 5,753 m (18,875 ft) above sea level at its head at Indira Col on the China border down to 3,620 m (11,875 ft) at its terminus. Entire Siachen Glacier with all major passes is currently under administration of India since 1984, while Pakistan controls region west of Saltoro Ridge.