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Medications that can cause night sweats. Night sweats are a common side effect of many medications, such as: 1  Depression medications (antidepressants). 2  Drugs used to regulate your hormones (hormone therapy). 3  Drugs that lower the level of sugar in your blood (hypoglycemic agents).
If cancer is causing your night sweats, you must get treatment for cancer to treat the night sweats that it causes. Cancer treatments vary by cancer type and stage. Common treatments include surgery, chemotherapy, and radiation. Some cancer treatment drugs may cause night sweats. This includes tamoxifen, opioids, and steroids. As your body adjusts to the treatment, the night sweats may subside. The off-label use of these drugs may relieve night sweats: the blood pressure medication clonidine; the epilepsy drug gabapentin; the acid-reducing drug cimetidine