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The most common side effects of niacin are: stomach upset, flushing, headache, reduced blood pressure upon standing (orthostatic hypotension), vomiting, diarrhea, itching and ; tingling sensations of the extremities. Flushing may be reduced by taking 325 mg of aspirin 30 minutes before the niacin and by increasing the dose of niacin slowly.
Common side effects of niacin include nausea, fatigue, pruritus and flushing; flushing being a major dose-limiting side effect. Hepatotoxicity Niacin in doses above 500 mg daily causes transient, asymptomatic elevations in serum aminotransferase levels in up to 20% of people.