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Spleen Pain. The spleen plays a highly important role in the human body, especially when it comes to protecting the immune system. When injured, it causes sharp pain, tingling sensation and a dull feeling at the lower, upper, left and right parts of the abdomen.
Enlarged Spleen Symptoms. Symptoms you may experience with an enlarged spleen include: 1  pressure or pain in the left upper part of your abdomen (near the stomach), 2  feeling full without eating a large meal,  or pain your left shoulder blade or shoulder area when taking a deep breath.