Although it was already well known for the quality of its Nebbiolo grapes, the widely accepted birthdate of Barbaresco is 1894, when Cantina Sociale di Barbaresco was founded, as before that date Nebbiolo grapes from the Barbaresco area were mostly sold to Barolo producers.
Nephron, functional unit of the kidney, the structure that actually produces urine in the process of removing waste and excess substances from the blood. There are about 1,000,000 nephrons in each human kidney. The most primitive nephrons are found in the kidneys (pronephros) of primitive fish, amphibian larvae, and embryos of more advanced vertebrates.
In this way, your kidneys regulate the body's level of these substances. The right balance is necessary for life, but excess levels can be harmful. In the nephron (left), tiny blood vessels intertwine with urine-collecting tubes. Each kidney contains about 1 million nephrons. In addition to removing wastes, your kidneys release three important hormones: 1  Erythropoietin (eh-RITH-ro-POYeh-tin), or EPO, which stimulates the bones to make red blood cells. 2  Renin (REE-nin), which regulates blood pressure.