Lyme disease is transmitted to humans by the bite of infected ticks of the Ixodes genus. Usually, the tick must be attached for 36 to 48 hours before the bacteria can spread. In North America, Borrelia burgdorferi sensu stricto and Borrelia mayonii are the cause.
A genetic predisposition (sometimes also called genetic susceptibility) is an increased likelihood of developing a particular disease based on a personâs genetic makeup. A genetic predisposition results from specific genetic variations that are often inherited from a parent.he World Health Organization offers information about genetic predisposition to several common diseases, including cancer, diabetes, cardiovascular disease, and asthma. Genetic Alliance UK offers a fact sheet on genetic predisposition to common genetic diseases.
Autoimmune Markers/Autoantibodies. Autoimmune diseases are accompanied by autoantibodies, which sometimes are only seen in this special disease-thus these autoantibodies can serve as a marker for the disease.If an antibody is a disease marker it is not absolutely necessary also a pathogenic antibody. marker with high sensitivity is detectable in all or most patients with a special disease. Again tissue transglutaminase antibodies is a good example for a marker with high sensitivity: about 96% of patients with celiac disease have a detectable titer of anti-tTG.