Pin It. Your thyroid is a small, butterfly-shaped gland located in your neck. This gland is responsible for several essential bodily functions, including regulating metabolism, mood, energy, heart rate, blood pressure, and body temperature. The thyroid regulates all of this by producing thyroid hormones.
Intrinsic factor (IF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach.It is necessary for the absorption of vitamin B12 (cobalamin) later on in the small intestine. In humans, the gastric intrinsic factor protein is encoded by the GIF gene.Haptocorrin (also known as HC, R protein, and transcobalamin I, TCN1), is a glycoprotein secreted by the salivary glands which binds to vitamin B 12.ere in the less acidic environment of the small intestine, pancreatic enzymes digest the glycoprotein carrier and vitaminB 12 can then bind to intrinsic factor. This new complex is then absorbed by the epithelial cells (enterocytes) of the ileum.
Question 1. Intrinsic factor is a protein that is produced by the parietal cells of the stomach. It binds to vitamin B12, thereby allowing absorption of the vitamin by intestinal cells. In pernicious anemia, an autoimmune disorder, autoantibodies are formed against intrinsic factor leading to its deficiency.