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Agonist. Definition. noun, plural: agonists. (pharmacology) A molecule that combines with a receptor on a cell to trigger physiological reaction. An example is an acetylcholine being the agonist that combines with the cholinergic receptor. (histology) A muscle that contracts while another muscle relaxes, e.g. when bending the elbow the biceps are the agonist.
Efficacy spectrum of receptor ligands. An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response. Whereas an agonist causes an action, an antagonist blocks the action of the agonist and an inverse agonist causes an action opposite to that of the agonist.ypes of agonists [edit]. Receptors can be activated by either endogenous (such as hormones and neurotransmitters) or exogenous (such as drugs) agonists, resulting in a biological response.