Mechanism of Action. Levocetirizine, the active enantiomer of cetirizine, is an anti histamine; its principal effects are mediated via selective inhibition of H1 receptors. The antihistaminic activity of levocetirizine has been documented in a variety of animal and human models. In vitro binding studies revealed that levocetirizine has an affinity for the human H1-receptor 2-fold higher than that of cetirizine (Ki = 3 nmol/L vs. 6 nmol/L, respectively).
A glacier calf, or chunk of ice, measuring nearly five square miles broke away from Greenland's Jakobshavn glacier sometime in August, making it the largest piece to ever break away from one of the world's fastest melting glaciers. glacier, calf, iceberg, jakobshavn, greenland.
At 76 km (47 mi) long, it is the longest glacier in the Karakoram and second-longest in the world's non-polar areas. It falls from an altitude of 5,753 m (18,875 ft) above sea level at its head at Indira Col on the China border down to 3,620 m (11,875 ft) at its terminus. Entire Siachen Glacier with all major passes is currently under administration of India since 1984, while Pakistan controls region west of Saltoro Ridge.