Mechanism of Action. Levocetirizine, the active enantiomer of cetirizine, is an anti histamine; its principal effects are mediated via selective inhibition of H1 receptors. The antihistaminic activity of levocetirizine has been documented in a variety of animal and human models. In vitro binding studies revealed that levocetirizine has an affinity for the human H1-receptor 2-fold higher than that of cetirizine (Ki = 3 nmol/L vs. 6 nmol/L, respectively).
A glacier calf, or chunk of ice, measuring nearly five square miles broke away from Greenland's Jakobshavn glacier sometime in August, making it the largest piece to ever break away from one of the world's fastest melting glaciers. glacier, calf, iceberg, jakobshavn, greenland.
Brokeback Mountain was the big winner today as Golden Globe nominations were announced. With seven nods, it led all films, which is an important Oscar indicator. More... Mountain Breaks the Bank. December 13th, 2005. Brokeback Mountain had the best per theatre average of the year, and the best for a Live Action film of all time.