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A locus is the specific physical location of a gene or other DNA sequence on a chromosome, like a genetic street address. The plural of locus is loci. locus is the specific physical location of a gene or other DNA sequence on a chromosome, like a genetic street address. The plural of locus is loci.
Full Definition of LOCUS. 1. 2. : the set of all points whose location is determined by stated conditions. 3. : the position in a chromosome of a particular gene or allele. See locus defined for English-language learners.See locus defined for kids.ull Definition of LOCUS. 1. 2. : the set of all points whose location is determined by stated conditions. 3. : the position in a chromosome of a particular gene or allele. See locus defined for English-language learners. See locus defined for kids.