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Medications that can cause night sweats. Night sweats are a common side effect of many medications, such as: 1  Depression medications (antidepressants). 2  Drugs used to regulate your hormones (hormone therapy). 3  Drugs that lower the level of sugar in your blood (hypoglycemic agents).
1 Taking certain medications can lead to night sweats. 2  Antidepressant medications are a common type of drug that can lead to night sweats. 3  From 8% to 22% of people taking antidepressant drugs have night sweats. 4  Other psychiatric drugs have also been associated with night sweats. Many other drugs can cause night sweats or flushing. 2  Hypoglycemia. 3  Low blood sugar can cause sweating. 4  People who are taking insulin or oral diabetes medications may have hypoglycemia at night that is accompanied by sweating.