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1,4-Dihydropyridine (DHP), an important class of calcium antagonist, inhibits the influx of extracellular Ca+2 through L-type voltage-dependent calcium channels. Three-dimensional (3D) structure of calcium channel as a receptor for 1,4-dihydropyridine is a step in understanding its mode of action. Protein structure prediction and modeling tools are becoming integral parts of the standard toolkit in biological and biomedical research.
Calcium-channel blockers prevent or slow the flow of calcium into the heart. Drugs in this category include: diltiazem (Dilt, Cardizem, Tilazem, Cartia XT) and verapamil (Calan, Isoptin). Cardiac glycosides slow down and control the heart rate by blocking the electrical conduction between the atria and ventricles.