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A locus is the specific physical location of a gene or other DNA sequence on a chromosome, like a genetic street address. The plural of locus is loci. locus is the specific physical location of a gene or other DNA sequence on a chromosome, like a genetic street address. The plural of locus is loci.
A quantitative trait locus is a section of DNA which correlates with variation in a phenotype. Usually the QTL is linked to, or contains, the genes which control that phenotype. QTLs are mapped by identifying which molecular markers correlate with an observed trait. This is often an early step in identifying and sequencing the actual genes that cause the trait variation.