NOTE: Documentation requirements are complex and may be subject to change at any time. Therefore, all cruise passengers should visit www.travel.state.gov (U.S. Department of State) or other authoritative source for the latest passport and visa requirements as well as any overseas travel advisories.
Ingenol mebutate (ingenol-3-angelate, PEP005, LEO Pharma trade name Picato) is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.dverse effects [edit]. Irritations of the application site are very common. This includes redness, scaling, crusting, pain, pruritus, and sometimes infection. Other side effects include eye irritation such as periorbital edema (3% of patients in studies), headache (2%) and nasopharyngitis (running nose, 2%).
How should I use Picato gel? Use Picato gel exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Use only enough of this medicine to cover the affected areas. Using too much of this medicine, or using it for too long can increase your risk of severe skin reactions. Do not take by mouth. Picato gel is for use only on the skin. Do not apply this medicine near your lips, mouth, or vagina. Do not apply Picato gel less than 2 hours before bedtime. Do not apply the medicine right after taking a shower. Do not use on sunburned skin, or on areas of skin that are still healing after surgery or treatment with other medications.