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1,4-Dihydropyridine (DHP), an important class of calcium antagonist, inhibits the influx of extracellular Ca+2 through L-type voltage-dependent calcium channels. Three-dimensional (3D) structure of calcium channel as a receptor for 1,4-dihydropyridine is a step in understanding its mode of action. Protein structure prediction and modeling tools are becoming integral parts of the standard toolkit in biological and biomedical research.
The following recommendations are provided for clinicians considering the use of a formulary long-acting dihydropyridine (LA DHP) calcium channel blocker (CCB) (e.g., amlodipine, felodipine, long-acting nifedipine) for the treatment of hypertension (HTN) and/or. angina.