The fourth great shinobi war was Started in: 1  In anime, Naruto shippuden episode 261. 2  In manga, it was chapter 516.
Neural sensitization is the process by which the response of a neuron to a given stimulus is increased. This increase lasts a long time-weeks or months at least.
What happens after Naive B cells become Sensitized B cells and T helper cells have arrived. Activated T helper cells stimulate Sensitized B cells to proliferate into Plasma cells (and some Memory B cells) (B cell doesn't really know what to do until helper T cell comes along)