Although it was already well known for the quality of its Nebbiolo grapes, the widely accepted birthdate of Barbaresco is 1894, when Cantina Sociale di Barbaresco was founded, as before that date Nebbiolo grapes from the Barbaresco area were mostly sold to Barolo producers.
Nephron, functional unit of the kidney, the structure that actually produces urine in the process of removing waste and excess substances from the blood. There are about 1,000,000 nephrons in each human kidney. The most primitive nephrons are found in the kidneys (pronephros) of primitive fish, amphibian larvae, and embryos of more advanced vertebrates.
Each kidney contains about 1 million tiny filtering units, called nephrons. Any disease that injures or scars the nephrons can cause kidney disease. Diabetes and high blood pressure can both damage your nephrons. High blood pressure can also damage the blood vessels of your kidneys, heart, and brain. The kidneys are highly vascularized, meaning they contain lots of blood vessels.