A high index of suspicion is essential. Given that manifestations of Reye syndrome are not unique to Reye syndrome but also are seen in a growing list of conditions, and given that no test is specific for Reye syndrome, the diagnosis must be one of exclusion. All children with manifestations suggestive of Reye syndrome should be tested for IEM.
A mood swing is an extreme or rapid change in mood. Such mood swings can play a positive part in promoting problem solving and in producing flexible forward planning. However, when mood swings are so strong that they are disruptive, they may be the main part of a bipolar disorder.
The definition of extreme is most remote or far from what is necessary or usual. An example of extreme is a fever of 104. An extreme is defined as something which is the farthest or highest, or things that are very different or far apart from one another. An example of extreme is the top of Mount Everest. An example of extreme is the range of feelings from depressed to very joyful.