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Functions of membrane proteins can also include cellâcell contact, surface recognition, cytoskeleton contact, signaling, enzymatic activity, or transporting substances across the membrane.
On the cytoplasmic side of the membrane, some membrane proteins connect to the cytoskeleton. On the exterior side of the membrane, some membrane proteins attach to the fibers of the extracellular matrix. The proteins of the plasma membrane have six major functions: 1. Transport of specific solutes into or out of cells.