NOTE: Documentation requirements are complex and may be subject to change at any time. Therefore, all cruise passengers should visit www.travel.state.gov (U.S. Department of State) or other authoritative source for the latest passport and visa requirements as well as any overseas travel advisories.
Ingenol mebutate (ingenol-3-angelate, PEP005, LEO Pharma trade name Picato) is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.dverse effects [edit]. Irritations of the application site are very common. This includes redness, scaling, crusting, pain, pruritus, and sometimes infection. Other side effects include eye irritation such as periorbital edema (3% of patients in studies), headache (2%) and nasopharyngitis (running nose, 2%).
Gelato is similar to ice cream, but it's denser and lower in fat. Just like ice cream is firmly engrained in American culture, gelato is a favorite dessert staple in Italy. It looks a lot like ice cream, sure, but what is it exactly? Ice cream is made with primarily full-fat cream, whereas gelato is usually made with whole milk, so it contains less fat than ice cream. Itâs also churned at a much slower pace than ice cream, resulting in a product thatâs dense, super-creamy, and less fluffy than ice cream because thereâs less air mixed in.