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Fifth disease is transmitted through respiratory droplets and contact with infected blood products. The incubation period (the time between the initial infection and the onset of symptoms) is usually between 4 and 21 days. People with fifth disease are most contagious before the onset of symptoms.ifth disease is transmitted through respiratory droplets and contact with infected blood products. The incubation period (the time between the initial infection and the onset of symptoms) is usually between 4 and 21 days. People with fifth disease are most contagious before the onset of symptoms.
Overview. Fifth disease is a mild rash illness caused by parvovirus B19. This disease is also called erythema infectiosum. It is more common in children than adults. A person usually gets sick within 4 to 14 days (sometimes up to 20 days) after getting infected with parvovirus B19.ransmission. People with fifth disease are most contagious before they get rash or joint pain and swelling. Parvovirus B19 spreads through respiratory secretions (such as saliva, sputum, or nasal mucus) when an infected person coughs or sneezes.