NOTE: Documentation requirements are complex and may be subject to change at any time. Therefore, all cruise passengers should visit www.travel.state.gov (U.S. Department of State) or other authoritative source for the latest passport and visa requirements as well as any overseas travel advisories.
Ingenol mebutate (ingenol-3-angelate, PEP005, LEO Pharma trade name Picato) is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.dverse effects [edit]. Irritations of the application site are very common. This includes redness, scaling, crusting, pain, pruritus, and sometimes infection. Other side effects include eye irritation such as periorbital edema (3% of patients in studies), headache (2%) and nasopharyngitis (running nose, 2%).
View. comments. A new treatment for skin damage that can lead to cancer has been created from the sap of a common garden weed. Picato gel is a fast-acting treatment for actinic keratosis (AK), which appears as red, rough patches of skin often on the face, balding scalp, backs of hands and trunk of the body.iew. comments. A new treatment for skin damage that can lead to cancer has been created from the sap of a common garden weed. Picato gel is a fast-acting treatment for actinic keratosis (AK), which appears as red, rough patches of skin often on the face, balding scalp, backs of hands and trunk of the body.