Mechanism of Action. Levocetirizine, the active enantiomer of cetirizine, is an anti histamine; its principal effects are mediated via selective inhibition of H1 receptors. The antihistaminic activity of levocetirizine has been documented in a variety of animal and human models. In vitro binding studies revealed that levocetirizine has an affinity for the human H1-receptor 2-fold higher than that of cetirizine (Ki = 3 nmol/L vs. 6 nmol/L, respectively).
Glacier Calf That Broke Off Greenland's Jakobshavn Could Be Largest Ever. The Jakobshavn glacier-Greenland's fastest-moving glacier located near Ilulissat-is seen in a NASA image taken by the Operational Land Imager (OLI) on the Landsat 8 satellite August 16, 2015.
Hardest Female First Ascent Ever for 15-Year Old Laura Rogora? Laura Rogora, age 15, has made the first ascent of La Gasparata, 8c+/9a (5.14c/d) at Collepardo, near Rome, after spending only four days on the route. This is one of only a couple of climbs in the running to be the hardest first ascent ever made by a female athlete, and certainly fits Rogora into an extremely elite group of young climbers.