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In primary hyperparathyroidism, the elevated levels of PTH cause elevated levels of blood calcium (hypercalcemia). Increased calcium and phosphorus excretion in the urine may cause kidney stones. The most common cause of primary hyperparathyroidism is a benign tumor called an adenoma on one of the parathyroid glands that secretes too much PTH. In other cases, the excess PTH is produced by two or more enlarged parathyroid glands, a condition called hyperplasia.
This increase in parathyroid hormone causes more calcium to be taken from the bone and more calcium to be reabsorbed by the intestines and kidney. Medical conditions that cause low blood calcium levels or interfere with the body's ability to break down and remove phosphate can lead to secondary hyperparathyroidism. Too much phosphate causes changes in calcium levels. Kidney failure is a common cause of secondary hyperparathyroidism. Kidney failure can interfere with the body's ability to remove phosphate. Other causes of secondary hyperparathyroidism may include: Calcium deficiency.