Doctors don't know what causes Paget's disease of the breast. The most widely accepted theory is that the disease results from an underlying ductal breast cancer. The cancer cells from the original tumor then travel through milk ducts to the nipple and its surrounding skin.
Glucose in the bloodstream provides the primary fuel for all body tissues. Blood glucose levels are highest during the digestive period after a meal. Your blood sugar is lowest when the stomach and intestines are empty. Under normal circumstances, the body tightly controls the amount of insulin in your blood. An organ called the pancreas, which is tucked behind the stomach releases the hormones insulin and glucagon to regulate blood sugar levels.
Your pancreas produces insulin and glucagon, two hormones that regulate sugar levels in your blood. Insulin and glucagon are secreted from your pancreas directly into your blood. When the concentration of glucose (a sugar) rises in your blood, insulin is released. Insulin lowers blood glucose levels by stimulating cells throughout your body to use and store glucose. Glucagon has the opposite effect of insulin.