NOTE: Documentation requirements are complex and may be subject to change at any time. Therefore, all cruise passengers should visit www.travel.state.gov (U.S. Department of State) or other authoritative source for the latest passport and visa requirements as well as any overseas travel advisories.
Ingenol mebutate (ingenol-3-angelate, PEP005, LEO Pharma trade name Picato) is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.dverse effects [edit]. Irritations of the application site are very common. This includes redness, scaling, crusting, pain, pruritus, and sometimes infection. Other side effects include eye irritation such as periorbital edema (3% of patients in studies), headache (2%) and nasopharyngitis (running nose, 2%).
Follow Following Unfollow Pending Disabled. A Stacy Wiegman, PharmD , Pharmacy, answered. Picato (also called ingenol mebutate) is a prescription gel used to treat actinic keratosis, a precancerous skin condition caused by overexposure to the sun. Actinic keratoses are small, rough spots found most often on the face, ears, arms and backs of hands, but they can also appear on other parts of the body. Picato was approved by the Food and Drug Administration in January 2012.