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Cetirizine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Cetirizine is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose. Cetirizine is also used to treat itching and swelling caused by chronic urticaria (hives). Cetirizine may also be used for purposes not listed in this medication guide.
Zyrtec Use in Dogs. March 21, 2010. Zyrtec, also known by its generic name cetirizine, is an over-the-counter antihistamine used to treat symptoms of allergy and inflammation. Although it's a human medication, vets routinely prescribe it for animals in what's called off-label use. Zyrtec is is usually given once a day.