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1,4-Dihydropyridine (DHP), an important class of calcium antagonist, inhibits the influx of extracellular Ca+2 through L-type voltage-dependent calcium channels. Three-dimensional (3D) structure of calcium channel as a receptor for 1,4-dihydropyridine is a step in understanding its mode of action. Protein structure prediction and modeling tools are becoming integral parts of the standard toolkit in biological and biomedical research.
Calcium channel blockers: Calcium channel blockers prevent calcium from penetrating muscle tissue in the heart and blood vessels. Since muscles need calcium to contract, calcium channel blockers cause blood vessels to relax and dilate, thereby lowering blood pressure. ARBs: These drugs prevent angiotensin from entering cells of the heart and blood vessels, dilating blood vessels and reducing the pressure the heart must work against. Direct-acting vasodilators: Unlike ACE inhibitors and ARBs, vasodilators directly relax the muscles in the walls of blood vessels.