Severe defects of the pyruvate dehydrogenase (PDH) complex and the benign chemical anomaly called pentosuria have been reported in very few (2-6) patients. Patients with inherited disorders of carbohydrate metabolism tend to be seen at tertiary centers, where specialist teams are available.
The phrase âletâs play it by earâ is used when someone wants to basically say âletâs not make any concrete plans â instead, letâs just see how things turn out and then we will decide what to do.â The phrase is used when talking about future plans, so itâs always referencing the future.
At that time, play it by ear meant to sing or play an instrument without printed music. By the 19th century, the same phrase came to mean to proceed one step at a time, trusting intuition and a subtle sense of timing, rather than a prearranged plan, to determine the proper course of action.