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In primary hyperparathyroidism, the elevated levels of PTH cause elevated levels of blood calcium (hypercalcemia). Increased calcium and phosphorus excretion in the urine may cause kidney stones. The most common cause of primary hyperparathyroidism is a benign tumor called an adenoma on one of the parathyroid glands that secretes too much PTH. In other cases, the excess PTH is produced by two or more enlarged parathyroid glands, a condition called hyperplasia.
1 If calcium levels are high and PTH levels are high, then the parathyroid glands are producing inappropriately high amounts of PTH. 2  A health practitioner may order X-rays or other imaging studies to help determine the cause and evaluate the severity of hyperparathyroidism. Hypoparathyroidism is a failure of the parathyroid glands to produce sufficient PTH. 2  It may be due to a variety of conditions and may be persistent, progressive, or transient. 3  Causes include an autoimmune disorder, parathyroid damage or removal during surgery, a genetic condition, or a severe illness.