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Fifth disease is transmitted through respiratory droplets and contact with infected blood products. The incubation period (the time between the initial infection and the onset of symptoms) is usually between 4 and 21 days. People with fifth disease are most contagious before the onset of symptoms.ifth disease is transmitted through respiratory droplets and contact with infected blood products. The incubation period (the time between the initial infection and the onset of symptoms) is usually between 4 and 21 days. People with fifth disease are most contagious before the onset of symptoms.
In brief: Until after the rash. Fifth disease, caused by parvovirus b19, is contagious from before symptoms begin, until the rash appears. When the rash appears, the patient is getting well, and only a little contagious (unknown exactly how contagious). Kids are allowed to return to school a couple of days after the rash appears.