NOTE: Documentation requirements are complex and may be subject to change at any time. Therefore, all cruise passengers should visit www.travel.state.gov (U.S. Department of State) or other authoritative source for the latest passport and visa requirements as well as any overseas travel advisories.
Ingenol mebutate (ingenol-3-angelate, PEP005, LEO Pharma trade name Picato) is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.dverse effects [edit]. Irritations of the application site are very common. This includes redness, scaling, crusting, pain, pruritus, and sometimes infection. Other side effects include eye irritation such as periorbital edema (3% of patients in studies), headache (2%) and nasopharyngitis (running nose, 2%).
Picato is derived from a common plant known a Milkweed and is now used to treat actinic keratosis (sunspots) and precancerous lesions all over the world. Important Facts on Picato (Ingenol Mebutate). 1  Picato gel is the first topical therapy to effectively treat actinic keratosis (AKs) in just two or three days.