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1,4-Dihydropyridine (DHP), an important class of calcium antagonist, inhibits the influx of extracellular Ca+2 through L-type voltage-dependent calcium channels. Three-dimensional (3D) structure of calcium channel as a receptor for 1,4-dihydropyridine is a step in understanding its mode of action. Protein structure prediction and modeling tools are becoming integral parts of the standard toolkit in biological and biomedical research.
Voltage-gated sodium channels (Na v) are key components for nerve excitability. They initiate and propagate the action potential in excitable cells, throughout the central and peripheral nervous system, thus enabling a variety of physiological functions to be achieved.odium channels, other than epithelial Na + channels (ENaC) or sodium leak channels (NALCN), belong to the superfamily of voltage-gated ion channels, which all share the property of carrying ions between cellular compartments in response to membrane voltage stimulation (Stock et al., 2013).