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1,4-Dihydropyridine (DHP), an important class of calcium antagonist, inhibits the influx of extracellular Ca+2 through L-type voltage-dependent calcium channels. Three-dimensional (3D) structure of calcium channel as a receptor for 1,4-dihydropyridine is a step in understanding its mode of action. Protein structure prediction and modeling tools are becoming integral parts of the standard toolkit in biological and biomedical research.
The use of this toxin as a biochemical probe has elucidated two distinct types of voltage-gated sodium channels present in humans: the tetrodotoxin-sensitive voltage-gated sodium channel (TTX-s Na + channel) and the tetrodotoxin-resistant voltage-gated sodium channel (TTX-r Na + channel).etrodotoxin binds to TTX-s Na + channels with a binding affinity of 5-15 nM, while the TTX-r Na + channels bind TTX with low micromolar affinity.