Mechanism of Action. Levocetirizine, the active enantiomer of cetirizine, is an anti histamine; its principal effects are mediated via selective inhibition of H1 receptors. The antihistaminic activity of levocetirizine has been documented in a variety of animal and human models. In vitro binding studies revealed that levocetirizine has an affinity for the human H1-receptor 2-fold higher than that of cetirizine (Ki = 3 nmol/L vs. 6 nmol/L, respectively).
Backcountry Splitboarding in Oregon and Beyond! Bend Glacier. The Bend Glacier is the largest of Broken Topâs two named glaciers, and is located on the north/northeast side of the mountain. Itâs meltwater feeds the headwaters of Squaw Creek, which eventually empties into the Deschutes River.
Perisher is Australiaâs largest ski resort with 47 ski lifts and a capacity of over 51,000 skiers lifted per hour. Transfield formed a joint venture with Japanese company Kumagai Gumi in the mid 1980s and led development of several major projects in the New South Wales Snowy Mountains.