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Functions of membrane proteins can also include cellâcell contact, surface recognition, cytoskeleton contact, signaling, enzymatic activity, or transporting substances across the membrane.
These proteins, called peripheral membrane proteins, are only associated with one side of the membrane or the other-never both. Only the transmembrane proteins can operate on both sides of the membrane at once, and they often serve to signal events taking place outside the cell, to vital functions inside the cell. They also serve as exits and entrances, transporting vital materials from one side of the membrane to the other.