constituting or forming a large number; numerous: many people. noting each one of a large number (usually followed by a or an): For many a day it rained. a large or considerable number of persons or things: A good many of the beggars were blind. the many, the greater part of humankind. many persons or things: Many of the beggars were blind.
Hives and angioedema can be caused by: 1  Foods. Many foods can trigger reactions in people with sensitivities. 2  Medications. Almost any medication may cause hives or angioedema. 3  Common allergens. Other substances that can cause hives and angioedema include pollen, animal dander, latex and insect stings.  Environmental factors.
Drugs that can cause hives and angioedema include aspirin and other NSAIDs (such as ibuprofen), high blood pressure medications (such as ACE inhibitors), and painkillers such as codeine. Chronic urticaria and/or angioedema are hives or swelling that lasts more than 6 weeks. The cause is usually harder to find than in acute cases. The causes can be similar to those of acute urticaria but can also include your immune system, chronic infections, hormonal disorders, and tumors. Physical urticaria are hives caused by direct physical stimulation of the skin -- for example, cold, heat, sunlight, vibration, pressure, sweating, and exercise.