The fourth great shinobi war was Started in: 1  In anime, Naruto shippuden episode 261. 2  In manga, it was chapter 516.
Neural sensitization is the process by which the response of a neuron to a given stimulus is increased. This increase lasts a long time-weeks or months at least.
1 In central sensitization, nociceptive neurons in the dorsal horns of the spinal cord become sensitized by peripheral tissue damage or inflammation. 2  This type of sensitization has been suggested as a possible causal mechanism for chronic pain conditions.