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Creatinine is a metabolic by-product of muscle metabolism, and normally appears in urine in relatively constant quantities over a 24 hour period with normal liquid intake. Therefore, urine creatinine can be used as an indicator of urine water content or as a marker identifying a specimen as urine. Greater than normal intake of water will increase the urine water content (lowering the creatinine level) consequently diluting the amount of drug in urine. Conversely, a limited intake of water can lead to an abnormally concentrated urine specimen (as occurs with dehydration) resulting in elevated creatinine levels.
Creatinine and creatinine clearance tests measure the level of the waste product creatinine (say kree-AT-uh-neen) in your blood and urine. These tests tell how well your kidneys are working.lood creatinine level. The blood creatinine level shows how well your kidneys are working. A high level may mean your kidneys are not working as they should. The amount of creatinine in the blood depends partly on the amount of muscle tissue you have.