There are many causes of nystagmus. Nystagmus may be present at birth. It may be a result of the lack of development of normal binocular fixation early on in life. This can occur if there is a cataract at birth or a problem is some other part of the visual system.
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In 1477, he was possibly in Iceland. In the autumn of 1477, Columbus sailed on a Portuguese ship from Galway to Lisbon, where he found his brother Bartolomeo, and they continued trading for the Centurione family. Columbus based himself in Lisbon from 1477 to 1485.