Ono Pharmaceuticals, Opdivo âs originator, has negotiated a price of Â¥150,200 ($1,459) per 20mg vial of Opvido, and Â¥729,849 for 100mg.pplying a similar mark-up to Opdivo, as well as accounting for the higher average body weight of 75kg in the US, gives a price for Opdivo of $118,000 per patient per year, if the same assumption is made about time on therapy.
*Philosophes did not support democracy. -George III of England (r. 1760-1820) and Louis XV of France (r. 1715-1774) had no interest in enlightened monarchy. -Catherine the Great of Russia, Frederick the Great of Prussia, and Joseph II of Austria were Europe's best-known enlightened despots.
What sorts of reforms did the enlightened despots make? 1) Frederick II- supported the philosopher's ideas but didn't want to give up any power. He granted religious freedom, reduced censorship, and improved education but did nothing to end serfdom because he wanted the support of the Nobles. 2) Joseph II- introduced legal reforms and freedom of press, abolished serfdom. 3) Catherine the Great- tried to give religious tolerance/abolish torture but it wasn't approved. Brought back serfdom.