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Creatinine is a metabolic by-product of muscle metabolism, and normally appears in urine in relatively constant quantities over a 24 hour period with normal liquid intake. Therefore, urine creatinine can be used as an indicator of urine water content or as a marker identifying a specimen as urine. Greater than normal intake of water will increase the urine water content (lowering the creatinine level) consequently diluting the amount of drug in urine. Conversely, a limited intake of water can lead to an abnormally concentrated urine specimen (as occurs with dehydration) resulting in elevated creatinine levels.
Creatine and Creatinine. Both are found naturally in our body. Itâs the creatinine youâll be interested in if you want to pass a drug test. The level of creatinine in your urine is an indicator of how well your kidneys are functioning. When you drink copious amounts of water in an attempt to flush controlled substances from your system, the sample will have reduced amounts of creatinine.