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Creatinine is a metabolic by-product of muscle metabolism, and normally appears in urine in relatively constant quantities over a 24 hour period with normal liquid intake. Therefore, urine creatinine can be used as an indicator of urine water content or as a marker identifying a specimen as urine. Greater than normal intake of water will increase the urine water content (lowering the creatinine level) consequently diluting the amount of drug in urine. Conversely, a limited intake of water can lead to an abnormally concentrated urine specimen (as occurs with dehydration) resulting in elevated creatinine levels.
The normal level of creatinine is usually 60 to 110 micromoles per litre, but the exact figures can vary from lab to lab. Having a low level of blood creatinine indicates nothing more than an efficient and effective pair of kidneys. A further test of kidney function is to collect all the urine passed over a period of twenty-four hours and then to compare the amount of creatinine in the blood to the level in the blood stream (creatinine clearance test). MOST POPULAR.