Side Effects. Side effects are rare; still symptoms like ear irritation, acute inflammation of the ear canal and pinna are reported. In some cases the pet might experience lack of appetite, vomiting, diarrhea, or hearing loss during the course of treatment, which might require immediate medical aid.
Furthermore, if the median age of a marathon participant is about 40, then the average maximum heart rate of a U.S. marathoner is about 180. Seventy percent of 180 is 126, while 80 percent is 144. Therefore, the heart rate of a mid-pack runner during a marathon is near the middle of the range -- between 126 and 144, or 135 beats per minute.
To compete in the London Marathon as a male elite runner you need to be able to run a marathon in under 2 hours 45 minutes (sub 3.15 if you are female). No small feat. But plenty elite runners manage this each year and are in with a shot of claiming victory. The World Marathon Majors compiles the big 5 city marathons (Boston, New York, Chicago, Berlin and our favourite London). In order to qualify you must score in the top 5 in at least 4 of these events. Again, no small feat.