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1 A biologic is manufactured in a living system such as a microorganism, or plant or animal cells. 2  Most biologics are very large, complex molecules or mixtures of molecules.
He or she might also decide not to prescribe a biologic if: 1  You have had tuberculosis in the past that has not been treated. 2  You have had other infections that were not treated. 3  You have cancer. 4  You have or had heart failure. 5  You have certain neurologic disorders.