Side Effects. Side effects are rare; still symptoms like ear irritation, acute inflammation of the ear canal and pinna are reported. In some cases the pet might experience lack of appetite, vomiting, diarrhea, or hearing loss during the course of treatment, which might require immediate medical aid.
Furthermore, if the median age of a marathon participant is about 40, then the average maximum heart rate of a U.S. marathoner is about 180. Seventy percent of 180 is 126, while 80 percent is 144. Therefore, the heart rate of a mid-pack runner during a marathon is near the middle of the range -- between 126 and 144, or 135 beats per minute.
Peak weeks. Sub-3 runners: four weeks before marathon, average 52 miles. 5+hour marathon finishers, six weeks before, average 20 miles. Distance and frequency. Unsurprisingly, the faster the finisher, the more miles they put in, and the more runs they do. The average time spent running per week was: Sub 3-hour finishers: 5hs and 22mins.