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1 A biologic is manufactured in a living system such as a microorganism, or plant or animal cells. 2  Most biologics are very large, complex molecules or mixtures of molecules.
Biologics (or biopharmaceuticals) are a class of drugs based on proteins that have a therapeutic effect. These large protein molecules â which are composed of more than 1,300 amino acids and can be as heavy as 150,000 g/mol (or 150 kDa) â are essentially copies or optimized versions of endogenous human proteins.