Side Effects. Side effects are rare; still symptoms like ear irritation, acute inflammation of the ear canal and pinna are reported. In some cases the pet might experience lack of appetite, vomiting, diarrhea, or hearing loss during the course of treatment, which might require immediate medical aid.
Furthermore, if the median age of a marathon participant is about 40, then the average maximum heart rate of a U.S. marathoner is about 180. Seventy percent of 180 is 126, while 80 percent is 144. Therefore, the heart rate of a mid-pack runner during a marathon is near the middle of the range -- between 126 and 144, or 135 beats per minute.
the long run is the cornerstone of marathon training in marathon training it has been found that 3 runs of 18 22 miles over the 8 weeks prior to the marathon are an important predictor of completing the marathont is possible to include some pick ups within your long run if you have run a few marathons already hal higdon suggests not running your long run at your marathon pace however for most long runs he and many others recommend 45 seconds to 90 seconds per mile slower than marathon pace