Side Effects. Side effects are rare; still symptoms like ear irritation, acute inflammation of the ear canal and pinna are reported. In some cases the pet might experience lack of appetite, vomiting, diarrhea, or hearing loss during the course of treatment, which might require immediate medical aid.
Furthermore, if the median age of a marathon participant is about 40, then the average maximum heart rate of a U.S. marathoner is about 180. Seventy percent of 180 is 126, while 80 percent is 144. Therefore, the heart rate of a mid-pack runner during a marathon is near the middle of the range -- between 126 and 144, or 135 beats per minute.
The Fuzzy Math Problem. Most runners plan for a faster marathon by reverse engineering their desired race day performance into a long run training pace. Someone looking to go from a 3:45 to a 3:30 marathon will do the math to figure that they need to run about an 8 min/mile pace on race day.