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Creatinine is a metabolic by-product of muscle metabolism, and normally appears in urine in relatively constant quantities over a 24 hour period with normal liquid intake. Therefore, urine creatinine can be used as an indicator of urine water content or as a marker identifying a specimen as urine. Greater than normal intake of water will increase the urine water content (lowering the creatinine level) consequently diluting the amount of drug in urine. Conversely, a limited intake of water can lead to an abnormally concentrated urine specimen (as occurs with dehydration) resulting in elevated creatinine levels.
Creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR).Many peopleâs creatinine are relatively low, this phenomenon is abnormal. There are many causes that can cause this problem, such as anemia and leukemia, etc. Once the patients appear this symptom, must pay attention. Many people know less about the cause of low serum creatinine. Lower creatinine illustrates that there is problem appearing in kidney. During renal function test, it is meaningless clinically, when the urea nitrogen and creatinine are lower than normal level. Many causes can lead to low creatinine, including general anemia, myodystrophy, amyotrophy, leukemia, diabetes insipidus and other diseases.