Side Effects. Side effects are rare; still symptoms like ear irritation, acute inflammation of the ear canal and pinna are reported. In some cases the pet might experience lack of appetite, vomiting, diarrhea, or hearing loss during the course of treatment, which might require immediate medical aid.
Furthermore, if the median age of a marathon participant is about 40, then the average maximum heart rate of a U.S. marathoner is about 180. Seventy percent of 180 is 126, while 80 percent is 144. Therefore, the heart rate of a mid-pack runner during a marathon is near the middle of the range -- between 126 and 144, or 135 beats per minute.
Steve Edwards, a member of the 100 Marathon Club, set the world record for running 500 marathons in the fastest average finish time of 3 hours 15 minutes, at the same time becoming the first man to run 500 marathons with an official time below 3 hours 30 minutes, on 11 November 2012 at Milton Keynes, England.