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Quick Answer. Hiccups resulting from surgery may be caused by a reaction to anesthesia or happen as a result of abdominal surgery or medical procedures such as a tracheotomy, states Healthline. Using a catheter to access the heart, bronchoscopy or using a stent in the esophagus can also result in long-term hiccups.
Problems with the liver, including swelling, infection, or masses can cause irritation of the diaphragm, which can cause hiccups. Some medications that can cause acid reflux may also have hiccups as a side effect. Most benzodiazepines, including diazepam , alprazolam and lorazepam can cause hiccups. In addition, medications such levodopa , nicotine, and ondansetron can cause hiccups.