Confidence votes 11. According to Wikipedia, the width of the Atlantic Ocean at its narrowest point is 2,848 kilometers (1,770 mi) between Brazil and Sierra Leone.
What causes PNH? It is not fully understood why people develop PNH. Inside the bone marrow, blood cells are made by stem cells (the seed cells of the marrow). PNH occurs due to a change (or mutation) in a gene in one of the stem cells in the bone marrow. This mutation happens in a gene called PIG-A and the cells made by this stem cell lack certain proteins on their surface making them âweakerâ than normal blood cells.
1 Signs and symptoms include stomach pain, difficulty swallowing, anemia, shortness of breath, and fatigue. 2  Life-threatening complications from PNH include blood clots, kidney failure, and damage to organs. , 3  hemolysis is always happening 2,3.t can also lead to signs and symptoms like 2,4 1  : FatigueTiredness, trouble concentrating, dizziness, and weakness to the point where even normal, everyday activities become a struggle. 2  In PNH, fatigue is often out of proportion to the amount of anemia, as measured by hemoglobin, because it is affected by hemolysis.