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Biochemistry of Dog Coat Color. The color of a dogâs coat is determined by relative levels of two pigments: eumelanin, which can be either brown or black, and pheomelanin, which is yellow to orange or red. Both pigments are generated by metabolism of tyrosine. A schematic diagram of the pathway is below. Schematic of the melanin synthesis pathways.
The following three results are possible: 1  Clear - the dog has two normal PFK genes and does not carry the mutation. 2  Carrier - The dog is heterozygous and has one normal and one mutant gene (allele). 3  Affected - the dog has two copies of the mutant gene (allele).