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Sensitive areas of tight muscle fibers can form in your muscles after injuries or overuse. These sensitive areas are called trigger points. A trigger point in a muscle can cause strain and pain throughout the muscle. When this pain persists and worsens, doctors call it myofascial pain syndrome. 1  Symptoms.
Myofascial pain syndrome facts. 1  Muscle pain, tenderness, and spasm are characteristics of myofascial pain syndrome. 2  Myofascial pain syndrome typically affects muscle in asymmetric areas of the body. 3  The precise cause of myofascial pain syndrome is not known. Myofascial pain syndrome leads to localized pain in the muscle tissue. 2  Poor sleep, fatigue, and stiffness are common in myofascial pain syndrome. 3  Myofascial pain syndrome is simply diagnosed based on the areas of complaints of muscle pain and associated tenderness upon examination.