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1 A biologic is manufactured in a living system such as a microorganism, or plant or animal cells. 2  Most biologics are very large, complex molecules or mixtures of molecules.
Virtually all drugs carry possible side effects. Biologics for the treatment of RA are no different. As seen above, biologics work in a number of different ways to reduce inflammation. They all interfere with some aspect of immune system function, though.For this reason, people taking a biologic drug may be at greater risk for certain infections.hese modern âbiologicsâ have greatly improved the effectiveness of treatment for many RA patients. Unlike older disease-modifying anti-rheumatic drugs (DMARDs), biologic DMARDs are made using biotechnology. They are genetically engineered to behave like natural immune system proteins.