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Watson and Crick describe structure of DNA1953. Photo: Model of DNA molecule. In the late nineteenth century, a German biochemist found the nucleic acids, long-chain polymers of nucleotides, were made up of sugar, phosphoric acid, and several nitrogen-containing bases.Later it was found that the sugar in nucleic acid can be ribose or deoxyribose, giving two forms: RNA and DNA.atson and Crick describe structure of DNA1953. Photo: Model of DNA molecule. In the late nineteenth century, a German biochemist found the nucleic acids, long-chain polymers of nucleotides, were made up of sugar, phosphoric acid, and several nitrogen-containing bases.
DNA and RNA are composed of nucleotides that are linked to one another in a chain by chemical bonds, called ester bonds, between the sugar base of one nucleotide and the phosphate group of the adjacent nucleotide.The sugar is the 3' end, and the phosphate is the 5' end of each nucleiotide.he sugar-phosphate backbone forms the structural framework of nucleic acids, including DNA and RNA. This backbone is composed of alternating sugar and phosphate groups, and defines directionality of the molecule.