1 VICODIN, VICODIN ES, and VICODIN HP should not be used if you are allergic to hydrocodone or acetaminophen. 2  Tell your healthcare provider if you are allergic to any other opioid pain medicine before taking this drug, as you may exhibit cross-sensitivity to hydrocodone.
Stiffness is generally worse with repeated use and better with rest. Heberden nodes are small, red nodules that occur at the last joint of the finger. They may deform the joint, creating the knobby knuckles and twisted fingers of severe OA.
In some cases, many knuckles can be affected. Inflammation in the knuckles can also cause knuckle pain and swelling. Medical conditions, such as rheumatoid arthritis, which is a chronic autoimmune disease, and is characterized by joint inflammation, will also cause knuckle pain and swelling.