The autonomic nervous system is the part of the nervous system that controls muscles of internal organs (such as the heart, blood vessels, lungs, stomach, and intestines) and glands (such as salivary glands and sweat glands).
Naltrexone is also used to reduce cravings for alcohol. Scientists are unsure how it works in relation to alcohol but it has been shown to reduce desire and cravings by blocking the same receptors that create feelings of pleasure when opioids are taken.
Since (+)-naloxone and (+)-naltrexone lack affinity for opioid receptors, they do not block the effects of opioid analgesic drugs, and so can be used to counteract the TLR4-mediated side effects of opioid agonists without affecting analgesia, though (+)-naloxone does reduce the reinforcing effects of opioid drugs.owever (+)-naloxone was also found to reduce the effects of stimulant drugs, suggesting additional actions beyond TLR4 antagonism (possibly as a sigma receptor antagonist), that might potentially result in unwanted side effects or drug interactions.