Learn about the three most important lines of latitude on Earth - the equator, Tropic of Cancer, and Tropic of Capricorn. Learn about the three most important lines of latitude on Earth - the equator, Tropic of Cancer, and Tropic of Capricorn.
General Discussion. Hairy cell leukemia (HCL) is a rare type of blood cancer characterized by abnormal changes in white blood cells known as B lymphocytes. The bone marrow creates too many of these defective cells, known as hairy cells because of the thin hair-like projections found on their surface.
Abl kinases are prototypic cytoplasmic tyrosine kinases and are involved in a variety of chromosomal aberrations in different cancers. This causes the. expression of Abl fusion proteins, such as Bcr-Abl, that are constitutively activated and drivers of tumorigenesis.