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Re: vitamin b12 deficiency how long will it take to get better. I just posted some new results. My b12 was 311. Doc said it was normal (in the normal range) and in six months of taking sublingual tabs two times a day (1000) it went up to 914.e: vitamin b12 deficiency how long will it take to get better. Steph--Your B-12 is where it should be. I run between 800 without supplements and 900 with. I have read twice lately where people have said that their doc wants them to be over 800 not 200 that we all have heard so many times.
Three out of 10 people who take metformin long-term develop a deficiency of vitamin B12. It can take 10 or 15 years to develop symptoms of B12 deficiency since the liver stores B12 - and it can take that long to deplete those stores.B12 deficiency causes damage to nerves that may be irreversible.urrent guidelines indicate that metformin is a cornerstone in the treatment of type 2 diabetes, but make no recommendations on the detection and prevention of vitamin B-12 deficiency during treatment. Our data provide a strong case for routine assessment of vitamin B-12 levels during long term treatment with metformin.