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Thrombophilia (sometimes hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels).
All of these make your blood hypercoagulable, meaning it makes it thick and slow moving, which increases your risk of having a blood clot or stroke. Hypercoagulable blood contributes to inflammation, because when your blood does not flow well, oxygen can't get to your tissues.