Side Effects. Side effects are rare; still symptoms like ear irritation, acute inflammation of the ear canal and pinna are reported. In some cases the pet might experience lack of appetite, vomiting, diarrhea, or hearing loss during the course of treatment, which might require immediate medical aid.
Furthermore, if the median age of a marathon participant is about 40, then the average maximum heart rate of a U.S. marathoner is about 180. Seventy percent of 180 is 126, while 80 percent is 144. Therefore, the heart rate of a mid-pack runner during a marathon is near the middle of the range -- between 126 and 144, or 135 beats per minute.
1 Tempos should be run at a slightly faster pace than your marathon time goal. 2  For example, if your marathon time goal is 8:30 minutes per mile (finishing the marathon at 3:42:52 - check out our pace chart.) you should be running your tempos at about 8:00 - 8:15 minutes per mile.