Side Effects. Side effects are rare; still symptoms like ear irritation, acute inflammation of the ear canal and pinna are reported. In some cases the pet might experience lack of appetite, vomiting, diarrhea, or hearing loss during the course of treatment, which might require immediate medical aid.
Furthermore, if the median age of a marathon participant is about 40, then the average maximum heart rate of a U.S. marathoner is about 180. Seventy percent of 180 is 126, while 80 percent is 144. Therefore, the heart rate of a mid-pack runner during a marathon is near the middle of the range -- between 126 and 144, or 135 beats per minute.
The primary elements of marathon training are: 1  Base mileage. Build your weekly mileage over time, running three-to-five times per week. 2  The long run. Do a long run every 7â10 days so your body can adjust gradually to long distances. 3  Speed work. Practice intervals and tempo runs to increase your cardio capacity.  Rest and recovery.