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Seroquel Dosage for Bipolar Disorder. The dose of Seroquel for bipolar disorder varies, depending on the particular type of bipolar disorder. The recommended starting dose of Seroquel for bipolar depression (in adults only) is Seroquel 50 mg, taken once daily at bedtime.Your healthcare provider will generally increase your dose quickly within a few days, up to Seroquel 300 mg, taken once daily at bedtime.For bipolar mania in adults, the recommended starting dose of Seroquel is 50 mg, taken twice a day.In general, your healthcare provider will increase your dose quickly within a few days, if needed, up to Seroquel 400 mg twice daily.our healthcare provider will generally increase your dose quickly within a few days, up to Seroquel 300 mg, taken once daily at bedtime. For bipolar mania in adults, the recommended starting dose of Seroquel is 50 mg, taken twice a day.
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