Side Effects. Side effects are rare; still symptoms like ear irritation, acute inflammation of the ear canal and pinna are reported. In some cases the pet might experience lack of appetite, vomiting, diarrhea, or hearing loss during the course of treatment, which might require immediate medical aid.
Furthermore, if the median age of a marathon participant is about 40, then the average maximum heart rate of a U.S. marathoner is about 180. Seventy percent of 180 is 126, while 80 percent is 144. Therefore, the heart rate of a mid-pack runner during a marathon is near the middle of the range -- between 126 and 144, or 135 beats per minute.
For those with some half marathon experience, breaking 2:00 (9:09 per mile pace) is a common goal, and that time is considered a decent half marathon time among runners. Highly competitive runners aim for other time barriers, like 1:30 (6:51 per mile pace). Or, they try to break a pace barrier, such as sub-7:00 per mile pace (1:31 half marathon time) or sub-8:00 per mile pace (1:45 half marathon time).