1 VICODIN, VICODIN ES, and VICODIN HP should not be used if you are allergic to hydrocodone or acetaminophen. 2  Tell your healthcare provider if you are allergic to any other opioid pain medicine before taking this drug, as you may exhibit cross-sensitivity to hydrocodone.
Stiffness is generally worse with repeated use and better with rest. Heberden nodes are small, red nodules that occur at the last joint of the finger. They may deform the joint, creating the knobby knuckles and twisted fingers of severe OA.
This could occur as a result of different causes. Pain and swelling in the knuckles can develop due to different conditions, which affect the structures in the knuckles, including nerves, skin, muscles, tendons, joints, bones, blood vessels, ligaments and connective tissue.