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Thrombophilia (sometimes hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels).
Hypercoagulation. Hypercoagulation or a hypercoagulable state results in a tendency to form thrombus. Blood flow problems and changes in blood vessel walls can cause platelets to gather or aggregate and adhere to vessel walls, initiating a pathophysiological clotting process.