President Hooverâs inactivity and belief in waiting things out left the United States in economic turmoil and in search of a new more dynamic leader. That leader was Franklin Delano Roosevelt who took over the presidency on January 20, 1933.
The mechanism of diltiazem hepatotoxicity is not known, but most cases are probably due to hypersensitivity. Diltiazem is metabolized by the cytochrome P450 system and is an inhibitor of CYP 3A4 activity, which can lead to serious drug-drug interactions and potentiation of the hepatotoxic effects of other medications.
A: Generalized body aches are not listed as a side effect of diltiazem in the package insert. Muscle cramps, however, are listed as a possible side effect. Derek Dore, PharmD. A: Diltiazem is a calcium channel blocker used to treat high blood pressure and angina. It should be taken with a full glass of water, either with or without food. Some reports indicate that grapefruit or grapefruit juice may interfere with the absorption of diltiazem.