1 VICODIN, VICODIN ES, and VICODIN HP should not be used if you are allergic to hydrocodone or acetaminophen. 2  Tell your healthcare provider if you are allergic to any other opioid pain medicine before taking this drug, as you may exhibit cross-sensitivity to hydrocodone.
Stiffness is generally worse with repeated use and better with rest. Heberden nodes are small, red nodules that occur at the last joint of the finger. They may deform the joint, creating the knobby knuckles and twisted fingers of severe OA.
When you âcrackâ your knuckles, or any other joint, it expands the space between your bones, creating negative pressure that draws synovial fluid into the new gap. This influx of synovial fluid is what causes the popping sound and feeling when you crack a knuckle. If you continually crack your knuckles, the synovial membrane and the surrounding ligaments will loosen, making it easier and easier for your joints to crack.