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There are two main strategies for the induction of transcription: a strong promoter is negatively controlled by a repressor protein and induction of transcription is effected by an inducer (a ligand that inactivates the repressor).
When transcription is arrested by the presence of a lesion in the transcribed strand of a gene, DNA repair proteins are recruited to the stalled RNA polymerase to initiate a process called transcription-coupled repair.Central to this process is the general transcription factor TFIIH that has ATPase activity.hen transcription is arrested by the presence of a lesion in the transcribed strand of a gene, DNA repair proteins are recruited to the stalled RNA polymerase to initiate a process called transcription-coupled repair.