Project Narrative. 2 to 3 sentences maximum. For NIH and other PHS agencies applications, this attachment will reflect the second component of the Project Summary: Relevance. Using no more than two or three sentences, describe the relevance of this research to public health. In this section, be succinct and use plain language that can be understood by a general, lay audience. A separate Research Plan component is required for NIH and other PHS agencies applications.
Methadone is a powerful narcotic. It can cause some people to feel drowsy, dizzy, or light-headed. People taking methadone should not drive a car or operate machinery. Intentional or accidental overdose of methadone can lead to unconsciousness, coma, or death.
Methadone is made by chemical synthesis and acts on opioid receptors. Methadone was developed in Germany around 1937 to 1939 by Gustav Ehrhart and Max BockmÃ¼hl. It was approved for use in the United States in 1947. Methadone is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. Globally in 2013, about 41,400 kilograms were manufactured. It is regulated similarly to other narcotic drugs.