Ono Pharmaceuticals, Opdivo âs originator, has negotiated a price of Â¥150,200 ($1,459) per 20mg vial of Opvido, and Â¥729,849 for 100mg.pplying a similar mark-up to Opdivo, as well as accounting for the higher average body weight of 75kg in the US, gives a price for Opdivo of $118,000 per patient per year, if the same assumption is made about time on therapy.
*Philosophes did not support democracy. -George III of England (r. 1760-1820) and Louis XV of France (r. 1715-1774) had no interest in enlightened monarchy. -Catherine the Great of Russia, Frederick the Great of Prussia, and Joseph II of Austria were Europe's best-known enlightened despots.
A ruler who governs with an iron fist, caring little for the welfare of the people, can be called despotic. Dictators and tyrants are often described as despotic. Despotic is the adjective form of the noun despot, which means tyrannical ruler.. If you live under despotic rule, you probably have few rights and may fear your government. Use despotic to describe rulers that rely on brute force (or the threat of it) rather than the rule of law to keep order.