Changes in biodiversity at a particular location affect the ability of the ecosystem to supply services and to recover from disturbances. More... 2.5 When humans modify an ecosystem to gain something, it often has negative effects on other components of ecosystems, leading to trade-offs.
The recommended starting dosage of both metformin and metformin ER for people taking insulin is 500 mg once daily. The maximum total daily dose for people taking insulin is 2500 mg for metformin and 2000 mg for metformin ER. Usually, when adding metformin to insulin, you should continue with your normal insulin dose.
For regular (not long-acting) metformin, the dosing varies with age, as follows: 1  Age 10 to 16 -- The recommended starting dose is metformin 500 mg twice daily. The maximum dosing for people in this age group is metformin 2000 mg total per day, divided into two or three doses.