Cell Wall & Gram classification â¢ Most bacteria fall into one of two groups: Gram-positive or Gram-negative â¢ Based on results of a differential staining test (the Gramâs stain) â¢ Primary basis for this distinction is differences in their cell walls Cell Wall: structure & composition Peptidoglycan (murein) â¢ Most importantcomponent
Chlorhexidine is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. The physiologic effect of chlorhexidine is by means of Decreased Cell Wall Integrity. Chlorhexidine is a biguanide compound used as an antiseptic agent with topical antibacterial activity.
Chlorhexidine is a broad-spectrum biocide effective against Gram-positive bacteria, Gram-negative bacteria and fungi. Chlorhexidine inactivates microorganisms with a broader spectrum than other antimicrobials (e.g. antibiotics) and has a quicker kill rate than other antimicrobials (e.g. povidone-iodine).acteria. Chlorhexidine is a positively-charged molecule that binds to the negatively-charged sites on the cell wall; it destabilizes the cell wall and interferes with osmosis. 5 The bacterial uptake of the chlorhexidine is very rapid, typically working within 20 seconds.