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A full set of sister chromatids is created during the S subphase of interphase, when all the DNA in a cell is replicated. Identical chromosome pairs are separated into two different cells during mitosis, or cellular division.
During meiosis, the process for gamete formation, homologous chromosomes replicate forming sister chromatids. 1  Sister chromatids pair up forming what is called a tetrad. While in close proximity, homologous chromosomes sometimes exchange sections of DNA. 2  At the end of meiosis, four daughter cells are produced.