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Doctors believe that the hypothalamus is the key to hot flashes. The hypothalamus is the section of the brain that regulates body temperature. The natural drop in estrogen that happens as a woman ages can often cause the hypothalamus to malfunction.
Due to estrogen levels decreasing, hormonal and biochemical imbalances occur, according to the 34 Menopause Symptoms website. The falling estrogen levels are thought to be the cause of both hot and cold flashes. The hypothalamus, the area of the brain responsible for body temperature regulation, becomes overactive. This causes the hypothalamus to release chemicals that cause blood vessels in the skin to expand in order for heat to be emitted.