1 VICODIN, VICODIN ES, and VICODIN HP should not be used if you are allergic to hydrocodone or acetaminophen. 2  Tell your healthcare provider if you are allergic to any other opioid pain medicine before taking this drug, as you may exhibit cross-sensitivity to hydrocodone.
Stiffness is generally worse with repeated use and better with rest. Heberden nodes are small, red nodules that occur at the last joint of the finger. They may deform the joint, creating the knobby knuckles and twisted fingers of severe OA.
Numerous medical conditions might cause knuckle swelling, including arthritis, gout, heart or kidney disease and infection. Blunt force trauma, of any kind, to the hand may also produce pain and swelling. Fluid retention caused by various medications may appear as joint or knuckle swelling, and individuals having an adverse reaction to antibiotics may also develop aching joints or swollen knuckles.