1 VICODIN, VICODIN ES, and VICODIN HP should not be used if you are allergic to hydrocodone or acetaminophen. 2  Tell your healthcare provider if you are allergic to any other opioid pain medicine before taking this drug, as you may exhibit cross-sensitivity to hydrocodone.
Stiffness is generally worse with repeated use and better with rest. Heberden nodes are small, red nodules that occur at the last joint of the finger. They may deform the joint, creating the knobby knuckles and twisted fingers of severe OA.
Reactive arthritis, a form of arthritis that often occurs after an infection of the genital, gastrointestinal system or urinary system, can cause a rash or hard nodules to develop on the palms of the hands or on the soles of the feet. Reactive arthritis also can affect the ankle, the heel and the toes, causing pain and swelling.