Side Effects. Side effects are rare; still symptoms like ear irritation, acute inflammation of the ear canal and pinna are reported. In some cases the pet might experience lack of appetite, vomiting, diarrhea, or hearing loss during the course of treatment, which might require immediate medical aid.
Furthermore, if the median age of a marathon participant is about 40, then the average maximum heart rate of a U.S. marathoner is about 180. Seventy percent of 180 is 126, while 80 percent is 144. Therefore, the heart rate of a mid-pack runner during a marathon is near the middle of the range -- between 126 and 144, or 135 beats per minute.
Finishing times for marathons (26.2 miles) range from a little over two hours for world-class, elite marathoners to 8+ hours for walkers. In terms of average marathon times, the median marathon finishing time in 2015 for men in U.S. marathons was 4:20:13 (9:55/mile pace), according to Running USA. The median finishing time for women was 4:45:30 (10:53/mile pace). Before running your marathon, it's definitely helpful to have an estimate of your marathon finishing time, so you know how to pace yourself properly.