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Do not take more than eight Midol PMS capsules in a 24 hour period. Each Midol PMS tablet contains 500 milligrams (mg) of acetaminophen. The recommended daily adult dose for acetaminophen is four grams (4000 mg), or 1000 mg in a single dose.
Best Answer: Midol usually kicks in within 20-30 minutes, but after the Midol is gone, why don't you just stop purchasing this over-priced medicine and begin to use plain old aspirin (buffered, if you worry about stomach issues) as that is the main ingredient in Midol and Pamprin (either aspirin or active ingredients in Tylenol).