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From Wikipedia, the free encyclopedia. The urea cycle (also known as the ornithine cycle) is a cycle of biochemical reactions occurring in many animals that produces urea ((NH2)2CO) from ammonia (NH3). This cycle was the first metabolic cycle discovered (Hans Krebs and Kurt Henseleit, 1932), five years before the discovery of the TCA cycle. In mammals, the urea cycle takes place primarily in the liver, and to a lesser extent in the kidney.
Urea. A by-product of protein metabolism that is formed in the liver. Because urea contains ammonia, which is toxic to the body, it must be quickly filtered from the blood by the kidneys and excreted in the urine.Mentioned in: Blood Urea Nitrogen Test, Escherichia Coli, Kidney Function Tests.. the chief nitrogenous endproduct of protein metabolism, formed in the liver from amino acids and from ammonia compounds; found in urine, blood, and lymph. 2. a pharmaceutical preparation of urea used to lower intracranial or intraocular pressure, to induce abortion, and as a topical skin moisturizer.ureÂ´al.