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The development of each chain is controlled at a separate genetic locus. Changes in the amino acid sequence of these chains results in abnormal hemoglobins. For example, hemoglobin S is found in sickle-cell disease, a severe type of anemia in which the red cells become sickle-shaped when oxygen is in short supply.
This shape allows normal red blood cells to be very flexible, moving easily through the blood vessels to deliver oxygen to the body. What is Sickle Cell Hemoglobin E Disease (Hemoglobin SE)? Hemoglobin SE disease (Hemoglobin SE) is a type of sickle cell disease.People with Hemoglobin SE disease have red blood cells that contain both hemoglobin S (sickle hemoglobin) and hemoglobin E. These individuals do not have hemoglobin A. People inherit this disease from both parents.his shape allows normal red blood cells to be very flexible, moving easily through the blood vessels to deliver oxygen to the body. What is Sickle Cell Hemoglobin E Disease (Hemoglobin SE)? Hemoglobin SE disease (Hemoglobin SE) is a type of sickle cell disease.