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An E-box (enhancer box) is a DNA response element found in some eukaryotes that acts as a protein-binding site and has been found to regulate gene expression in neurons, muscles, and other tissues.
VirtualBox is a so-called hosted hypervisor (sometimes referred to as a type 2 hypervisor). Whereas a bare-metal or type 1 hypervisor would run directly on the hardware, VirtualBox requires an existing operating system to be installed. It can thus run alongside existing applications on that host.