A: The function of the cartilaginous rings of the trachea is to stabilize the trachea and keep it rigid while allowing the trachea to expand and lengthen when the person breathes. If the trachea was not supported in this way, it would simply collapse because of the pressure of the chest.
HCM remains the most common cardiovascular genetic disorder, occurring in at least 1 in 500 people in the general population. 7 HCM is a primary inherited disorder of the myocardium characterized by hypertrophy, usually of the left ventricle, in the absence of other loading conditions such as hypertension.
The most common mutation in the lamin A/C is the homozygous Arg527His (arginine replaced by histidine at position 527) substitution in exon 9 of the LMNA gene Other know mutations are Ala529Val and Arg527His/Val440Met.atients with classical laminopathy have mutations in the gene coding for lamin A/C (LMNA gene). More recently, mutations in lamin B (LMNB2 gene) or genetic defects leading to changes in lamin B abundance were identified as cause for laminopathies.