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exotoxin exÂ·oÂ·toxÂ·in (Äk'sÅ-tÅk'sÄ­n) n. A toxin secreted by a microorganism and released into the environment in which it grows. Also called extracellular toxin.
Endotoxin vs Exotoxin. 1  Endotoxins are lipopolysaccharides, while exotoxins are soluble proteins produced by pathogenic bacteria. 2  Both gram negative and gram positive bacteria produce exotoxins while endotoxins are produced by gram negative bacteria.  Endotoxins cannot act as enzymes, but exotoxins can act as enzymes.