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Short-acting insulin covers your insulin needs during meals. It is taken about 30 minutes to an hour before a meal to help control blood sugar levels. This type of insulin takes effect in about 30 minutes to one hour, and peaks after two to four hours. Its effects tend to last about five to eight hours.
The most common first step in the initiation of insulin therapy is to use a single daily injection of a long-acting insulin analog such as glargine or detemir insulin. These modified insulins are absorbed slowly and result in nearly constant basal plasma concentrations, which in most patients last for 24 h or longer.