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Januvia Substitutes. If JanuviaÂ® (sitagliptin) is not working for you, or if it is causing bothersome side effects, you may want to ask your healthcare provider about substituting another medication. Several alternatives to Januvia are available for type 2 diabetes. These include other oral diabetes drugs, such as:
Through consuming licorice, grapefruit, ginger, or hot peppers, you can increase the ability of this medication to decrease blood sugar levels in the body. Sitagliptin, which is also known as Januvia gets processed in the liver with the CYP2C8 and CYP3A4 enzymes. Avoid eating too much fruit and drinking fruit juices as these will interfere with the enzymes and they will increase the possibility of acquiring the side effects caused by the medication. When using Sitagliptin, you should avoid the consumption of mangoes, oranges, dragon fruits, rambutans, passion fruits, pawpaws, wild grapes, pomegrenates, wild mullberies, and kiwis. Pioglitazone, which is also known as Actos, is processed with the CYP2C8 enzyme.