However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
Drinking Smoke. Tobacco was introduced to Europe by the Spanish, who had learned to smoke it from Native Americans. Despite some early criticism of drinking smoke, tobacco became popular among the middle classes in England. Much of the tobacco smoked in England was grown in the West Indies.