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Januvia Substitutes. If JanuviaÂ® (sitagliptin) is not working for you, or if it is causing bothersome side effects, you may want to ask your healthcare provider about substituting another medication. Several alternatives to Januvia are available for type 2 diabetes. These include other oral diabetes drugs, such as:
New FDA Warning About Januvia Joint Pain Side Effect. The FDA warns that Januvia and similar diabetes drugs (gliptins) can cause crippling joint pain. âThe U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines sitagliptin, saxagliptin, linagliptin, and alogliptin may cause joint pain that can be severe and disabling.