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From Wikipedia, the free encyclopedia. The urea cycle (also known as the ornithine cycle) is a cycle of biochemical reactions occurring in many animals that produces urea ((NH2)2CO) from ammonia (NH3). This cycle was the first metabolic cycle discovered (Hans Krebs and Kurt Henseleit, 1932), five years before the discovery of the TCA cycle. In mammals, the urea cycle takes place primarily in the liver, and to a lesser extent in the kidney.
The urea cycle is the part of the process in the body where food turns to energy and waste is eliminated. When you eat foods with protein in them â such as meat, fish, eggs, dairy products, nuts, beans, or soy â your body breaks the protein down.ne of the waste products of protein metabolism is ammonia. Too much ammonia can be toxic and harmful to the body. Enzymes in the urea cycle convert this toxic ammonia into a nontoxic substance called urea, which can be eliminated from the body. 1, 2.