Acute interstitial nephritis is an important cause of acute renal failure resulting from immune-mediated tubulointerstitial injury, initiated by medications, infection, and other causes. Acute interstitial nephritis may be implicated in up to 15 percent of patients hospitalized for acute renal failure.
The first player places one of their dominoes (right-side up) on the table. The second player tries to put a domino on the table that matches one side of what's already there. If a player cannot go, the player picks a domino from the pile and skips that turn. The chain of the played dominoes develops randomly, and can look a lot like a snake.
Step 6: Draw if you can't play. When players do not have a domino that matches one of the open dominos on the board, they draw from the pile of extra dominos until they draw a playable piece. If there are no dominos left, players lose their turn. Tip: The pile of leftover dominos is also known as the boneyard.