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exotoxin exÂ·oÂ·toxÂ·in (Äk'sÅ-tÅk'sÄ­n) n. A toxin secreted by a microorganism and released into the environment in which it grows. Also called extracellular toxin.
A-B Toxins. Most exotoxins are A-B or type III toxins. A-B toxins consist of two polypeptides. The A polypeptide is the enzyme and the B polypeptide is a binding component. B binds to the cell, the complete toxin is taken into the cell, the two subunits separate, and the A subunit enzymatically kills the cell. Membrane Disrupting Toxins. Type II toxins, disrupt host cell plasma membranes.