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From Wikipedia, the free encyclopedia. The urea cycle (also known as the ornithine cycle) is a cycle of biochemical reactions occurring in many animals that produces urea ((NH2)2CO) from ammonia (NH3). This cycle was the first metabolic cycle discovered (Hans Krebs and Kurt Henseleit, 1932), five years before the discovery of the TCA cycle. In mammals, the urea cycle takes place primarily in the liver, and to a lesser extent in the kidney.
Best Answer: ...the ammonia deposited in the mitochondria of hepatocytes (liver cells) is converted to urea in the urea cycle.. The urea cycle begins inside liver mitochondria.... - Lehninger: Principles of Biochemistry- 5th edition, 2008, p. 682. In mammals, a COMPLETE urea cycle functions only in liver, the major site of urea synthesis. - Biochemical, Physiologicalo, Molecular Aspects of Human Nutrition - 2nd edition, by Martha Stipanuk, 2006, p. 412. So, the answer is the liver because that is the ONLY organ in which the COMPLETE cycle occurs.