The acute form of hepatitis, generally caused by viral infection, is characterized by constitutional symptoms that are typically self-limiting. Chronic hepatitis presents similarly, but can manifest signs and symptoms specific to liver dysfunction with long-standing inflammation and damage to the organ.
1 Hydromorphone is a minor metabolite of morphine and may be excreted in urine at concentrations up to 2.5% of the morphine concentration. 2  Consequently, the detection of minor amounts of hydromorphone in urine containing high concentrations of codeine should not be interpreted as evidence of hydromorphone use.
Pharmacokinetics And Metabolism. The analgesic activity of DILAUDID (hydromorphone hydrochloride) is due to the parent drug, hydromorphone. Hydromorphone is rapidly absorbed from the gastrointestinal tract after oral administration and undergoes extensive first-pass metabolism.