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The development of each chain is controlled at a separate genetic locus. Changes in the amino acid sequence of these chains results in abnormal hemoglobins. For example, hemoglobin S is found in sickle-cell disease, a severe type of anemia in which the red cells become sickle-shaped when oxygen is in short supply.
Definition of Cancer, Hodgkin disease (adult). Cancer, Hodgkin disease (adult): A type of lymphoma, a cancer that develops in the lymph system, part of the body's immune system. Because there is lymph tissue in many parts of the body, Hodgkin's disease can start in almost any part of the body. The cancer can spread to almost any organ or tissue in the body, including the liver, bone marrow, and spleen.