However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
Slaves in Florida Spanish residents in St. Augustine, the first permanent settlement in. Florida, import African slaves. 1612. The first commercial tobacco crop is raised in Jamestown, Virginia. 1619. Twenty slaves in Virginia Africans brought to Jamestown are the first slaves imported.