SKK. Either microwave or bake. Depending on the size of the potato: In microwave prick with fork to allow steam to escape and microwave for 10 - 15 minutes or until the potato feels soft enought to eat. In oven, also prick with fork and back at 350 for 30 40 minutes.1 Person agrees.epending on the size of the potato: In microwave prick with fork to allow steam to escape and microwave for 10 - 15 minutes or until the potato feels soft enought to eat. In oven, also prick with fork and back at 350 for 30 40 minutes. 1 Person agrees.
To the Editor: Somatic mutations in the gene encoding calreticulin (CALR) were recently described in the majority of patients with myeloproliferative neoplasms without mutations in the Janus kinase 2 gene (JAK2).n this patient, the CALR mutation was a deletion (p.L367fs*46), which was detected in two samples obtained before interferon alfa therapy and was reduced in two subsequent samples (Figure 1). Both patients reported moderate fatigue and mood changes, which resolved after discontinuation of interferon alfa.
The gene responsible for HGPS is called LMNA (pronounced âlamin-aâ). One tiny spelling mistake in the DNA sequenceof LMNA is responsible for Progeria. This type of gene change is called apoint mutation. The LMNA gene normally makes a protein called lamin A,which is an important protein for most cells of our bodies. Lamin A is foundin the cell nucleus (the part of each cell that contains the DNA) and helpsmaintain the shape and function of the cell. In Progeria, the LMNA mutation causes the gene to produce an abnormalLamin A protein called progerin. In children with Progeria, many cells in thebody â such as the blood vessels, skin, and bones â make progerin protein.As the children age, progerin builds up in these cells causing progressivedisease.