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The development of each chain is controlled at a separate genetic locus. Changes in the amino acid sequence of these chains results in abnormal hemoglobins. For example, hemoglobin S is found in sickle-cell disease, a severe type of anemia in which the red cells become sickle-shaped when oxygen is in short supply.
By Mayo Clinic Staff. A high hemoglobin count indicates an above-normal level of hemoglobin in your blood. Hemoglobin (often abbreviated as Hb or Hgb) is the oxygen-carrying component of red blood cells. A high hemoglobin count is somewhat different from a high red blood cell count, because each cell may not have the same amount of hemoglobin proteins. Therefore, you could have a high hemoglobin count even if your red blood cell count falls within the normal range.