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An E-box (enhancer box) is a DNA response element found in some eukaryotes that acts as a protein-binding site and has been found to regulate gene expression in neurons, muscles, and other tissues.
A sandbox is a copy of their production enviroment of Salesforce which can be used to develop in, or it could be used just to train users so that users know that whatever they do they can't effect the live data in the production org.