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An E-box (enhancer box) is a DNA response element found in some eukaryotes that acts as a protein-binding site and has been found to regulate gene expression in neurons, muscles, and other tissues.
Top Definition. hotbox. A hotbox is an air-tight room or vehicle that contains one or more pot-smokers smoking one or more joints. The exhaled smoke and the smoke coming from the joint, unable to escape, circulates and thus is breathed in and is not wasted.op Definition. hotbox. A hotbox is an air-tight room or vehicle that contains one or more pot-smokers smoking one or more joints. The exhaled smoke and the smoke coming from the joint, unable to escape, circulates and thus is breathed in and is not wasted.