What is it: A Process Control Plan (PCP) is a summary of defect prevention and reactive detection techniques. The overall intent of the PCP is to control the product characteristics and the associated process variables to ensure capability (around the identified target or nominal) and stability of the product over time.
Various compounds can reduce the activity of enzymes. They may act in a variety of different ways, and indeed may be reversible or irreversible inhibitors of the enzyme. An irreversible inhibitor causes covalent modification of the enzyme, so that its activity is permanently reduced.
The inhibitor chemicallyresembles a (one of the) substrate(s) and binds in the active site in the same way as thesubstrate(s) binds. The inhibitor, however, has a functional group, ususally a leaving group,that is replaced by a nucleophile in the enzyme active site.herefore thistype of inhibition is called suicide inhibition or affinity labeling and the inhibitor is called a suicide inhibitor. This reaction with the suicide inhibitor removes active enzyme from the system; this removal is measured as inhibition.