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There are more than 400 types of anemia. These types of anemia are divided into three main groups, according to their cause. There is anemia caused by blood loss, by decreased or faulty red blood cell production, and by destruction of red blood cells.
Macrocytic anemia can be broken into two main types: megaloblastic and nonmegaloblastic macrocytic anemias. Megaloblastic macrocytic anemia. Most macrocytic anemias are also megaloblastic. Megaloblastic anemia is a result of errors in your red blood cell DNA production. This causes your body to make red blood cells incorrectly. Possible causes include: vitamin B-12 deficiency; folate deficiency; some medications, such as chemotherapy drugs like hydroxyurea, antiseizure medications, and antiretroviral drugs used for people with HIV; Nonmegaloblastic macrocytic anemia . Nonmegaloblastic forms of macrocytic anemia may be caused by a variety of factors. These can include: chronic alcohol use disorder (alcoholism) liver disease; hypothyroidism