Acetylcholine is released from a presynaptic neuron into the synaptic cleft. Once in the synaptic gap, acetylcholine can: - Bind to presynaptic receptors: presynaptic activation or inhibition leads to automodulation of the presynaptic cholinergic neuron.
When welts are a sign of a medical problem, they are usually accompanied by other symptoms which provide clues to the problem. Physical trauma such as a blow can cause a welt, and welts can also be caused by allergic reactions, infections, injections, insect bites, and skin reactions, in very sensitive people. For example, in people with dermographism, even a gentle touch to the skin can cause a welt to emerge.
Hives are raised, often itchy, red bumps (welts) on the surface of the skin. They are usually an allergic reaction to food or medicine. They can also appear without cause. When you have an allergic reaction to a substance, your body releases histamine and other chemicals into the blood. This causes itching, swelling, and other symptoms. Hives are a common reaction. Persons with other allergies, such as hay fever, often get hives. When swelling or welts occur around the face, especially the lips and eyes, it is called angioedema.