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The development of each chain is controlled at a separate genetic locus. Changes in the amino acid sequence of these chains results in abnormal hemoglobins. For example, hemoglobin S is found in sickle-cell disease, a severe type of anemia in which the red cells become sickle-shaped when oxygen is in short supply.
HGB test or Hemoglobin test is a test to determine the levels of hemoglobin circulating in the blood.Hemoglobin is contained in the red blood cells and is important in the transport of oxygen from the lungs to the various tissues of the body.It also helps in maintaining the proper structure and shape of red blood cells. If hemoglobin levels are not normal, it may indicate certain illnesses.Usually hemoglobin tests are part of CBC or complete blood count. This is a generic blood test known to many and this involves measurement of certain blood components like, red blood cells, white blood cells, platelets, hematocrit, and hemoglobin.emoglobin tests are done to know if a person has anemia or polycythemia. These conditions involve abnormal measurements of hemoglobin in the blood. When a person has anemia, the function of the red blood cells will be hampered leading to various complications.