Acute interstitial nephritis is an important cause of acute renal failure resulting from immune-mediated tubulointerstitial injury, initiated by medications, infection, and other causes. Acute interstitial nephritis may be implicated in up to 15 percent of patients hospitalized for acute renal failure.
The first player places one of their dominoes (right-side up) on the table. The second player tries to put a domino on the table that matches one side of what's already there. If a player cannot go, the player picks a domino from the pile and skips that turn. The chain of the played dominoes develops randomly, and can look a lot like a snake.
This domino may normally be played either. 1  on the player's own train, or. 2  on another player's train, if that train is marked with a penny, to show that its owner was unable to play on it at their last move, or.  on an extra train, known as the Mexican Train or Caboose, which is always open to all players.