However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
TOBACCO TIMELINE. 1  Prehistory: In 2010, tobacco was found that dates to the Pleistocene Era 2.5 million years ago. 2  Paleontologists from the Meyer-Honninger Paleontology Museum discovered the small block of fossilised tobacco in the Maranon river basin in northeastern Peru.