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1 If the blood clot is large enough, it can block blood from exiting the right side of the heart, thus preventing blood from entering the lungs.  No blood enters the left side of the heart to pump blood throughout the rest of the body. This can result in shock (circulatory collapse) and sudden death.
In most cases, pulmonary embolism is caused by a blood clot in the leg that breaks loose and travels to the lungs. A blood clot in a vein close to the skin is not likely to cause problems. But having blood clots in deep veins (deep vein thrombosis) can lead to pulmonary embolism.f a large blood clot blocks the artery in the lung, blood flow may be completely stopped, causing sudden death. A smaller clot reduces the blood flow and may cause damage to lung tissue. But if the clot dissolves on its own, it may not cause any major problems. Symptoms of pulmonary embolism usually begin suddenly.