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Some common side effects of Depo Provera (medroxyprogesterone) are changes in menstrual periods, weight gain, weakness, tiredness, nervousness, irritability, depression, difficulty falling asleep or staying asleep, hot flashes, breast pain, swelling, or tenderness, leg cramps and back or joint pain.
The absence of periods is not harmful, and periods usually return to normal after Depo-Provera is stopped. If unusually heavy or continuous bleeding occurs, you should see your doctor. Other possible side effects include weight gain, headaches, nervousness, abdominal discomfort, dizziness and weakness or fatigue.o. Depo-Provera only works for about 3 months. The shot must be repeated every 3 months to prevent pregnancy. After a woman stops using Depo-Provera, her normal ovarian function returns after a short time. However, it takes an average of 9 to 10 months to get pregnant after getting the last shot.