However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
In tobacco, though, Virginia finally stuck the jackpot. Within a few years of Rolfeâs first crop, shareholders in the Virginia Company were exchanging shares of stock for 100-acre land-grants to get in on the tobacco rush, according to Nancy Egloff, a historian with the Jamestown-Yorktown Foundation. Immigration to the colony surged.