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The development of each chain is controlled at a separate genetic locus. Changes in the amino acid sequence of these chains results in abnormal hemoglobins. For example, hemoglobin S is found in sickle-cell disease, a severe type of anemia in which the red cells become sickle-shaped when oxygen is in short supply.
The definition of hemoglobin is the red iron pigment that makes red blood cells red. An example of hemoglobin is what brings oxygen from the lungs to the body's tissue. 1  YourDictionary definition and usage example. 2  The protein in the red blood cells of vertebrates that carries oxygen from the lungs to tissues and that consists of four polypeptide subunits, each of which is bound to an iron-containing heme molecule.