However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
1600s. ( 1 1607) Jamestown, first permanent English settlement established; Indians attacked, killed 1, wounded 11; John Smith captured by Indians. ( 2 1608) More settlers arrived; John Smith released; fire destroyed all the homes. ( 3 1611) John Rolfe introduces his tobacco seeds. ( 1612) First crop of tobacco exported.