However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
Acceptance of tobacco use was less than unanimous. In 1628, Shah Sefi punished two merchants for selling tobacco by pouring hot lead down their throats. In 1634 Czar Alexis of Russia created new penalties for smoking. For the first offense, the punishment was whipping, a slit nose, and transportation to Siberia.