An IRB/IEC should have: 1  At least five members. 2  Members with varying backgrounds. 3  At least one member must represent a non-scientific area (a lay member) 4  At least one member must not be affiliated with the institution or the trial site (an independent member)
Vesicles and Vacuoles Vesicles and vacuoles are membrane-bound sacs that function in storage and transport. Vacuoles are somewhat larger than vesicles, and the membrane of a vacuole does not fuse with the membranes of other cellular components. Vesicles can fuse with other membranes within the cell system (Figure 1).
In general, the term vesicle refers to a small sac or cyst that contains fluid or gas. In cell biology, vesicle refers to the bubble-like membranous structure that stores and transports cellular products, and digests metabolic wastes within the cell. The cell forms vesicles during exocytosis, endocytosis, and intracellular transport. Vesicles may be produced artificially and are referred to as lyposomes. Some of their functions are associated with metabolism, transport, storage of food and enzymes, and buoyancy. There are different forms of vesicles: vacuoles, lysosomes, transport vesicles, secretory vesicles (e.g. synaptic vesicles), extracellular vesicles (e.g. exosomes, microvesicle, etc.), and gas vesicles. Word origin: Latin vÄsÄ«cula, diminutive of vÄsÄ«ca, bladder, blister See also: organelle; Related term(s): Neurotransmitter vesicle; Biliary vesicle