However, some people who have early-onset Alzheimer's don't have mutations in these three genes. That suggests that this early-onset form of Alzheimer's disease is linked to other genetic mutations that haven't been identified yet.
Early history Cigars, cigarettes Cancer by the carton Legal history Surgeon General's warning. (CNN) -- Tobacco was first used by the peoples of the pre-Columbian Americas. Native Americans apparently cultivated the plant and smoked it in pipes for medicinal and ceremonial purposes.
It is not know what company was the first to produce cigarettes with filters, however it is well-known that first filter appeared in Europe. At those times cigarette filters didnât find a lodgement in the tobacco industry, as there were no such equipments able to combine filter with cigarette. Only in 1935 English scientists created such a machine, which made filter production a profitable business.