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Short-acting insulin covers your insulin needs during meals. It is taken about 30 minutes to an hour before a meal to help control blood sugar levels. This type of insulin takes effect in about 30 minutes to one hour, and peaks after two to four hours. Its effects tend to last about five to eight hours.
Twice-daily administration of NPH insulin and regular insulin usually works adequately while endogenous insulin is still being produced. Two thirds of the total daily insulin dose may be given 20 to 30 minutes before breakfast, and one third of the dose may be given 20 to 30 minutes before the evening meal.As an estimate, NPH insulin and regular insulin can be given in a 2:1 ratio for the breakfast dose and a 1:1 ratio for the evening-meal dose.he time it takes to absorb one half of an injected dose of insulin may vary by 25 to 50 percent among individual patients. 5 For example, NPH insulin may have a duration of activity of 18 hours in one patient but an effective activity of only 9 or 10 hours in another patient.