Research in knockout mice has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Although your white blood cells account for only about 1 percent of your blood, their impact is significant. White blood cells, also called leukocytes, are essential for good health and protection against illness and disease. Think of white blood cells as your immunity cells.
However, too much of white blood cells doesn't always mean a good thing. A high white blood cell count(also called leukocytosis) isn't a specific disease but could indicate an underlying problem. This is why high white blood cell count always requires further medical evaluation. A normal white blood cell count is between 4,500 and 10,000 cells per microliter. In the absence of any disease, they form just about 1% by volume of the total blood in the body.