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Answers. Best Answer: Alprazolam (xanax) has a half life of 6 - 12 hours so half of the drug will be gone in about 9 hours and then it will be down to a quarter of your dose in 18 hours etc. It should be completely undetectable within 3 - 5 days.
So it will take days for it to leave your system depending on what dose is administered. However, Xanax is a short acting medication compared to other drugs in its class. It will start working in minutes , peak at about 2 hours, but the effects of the medication will go away in roughly 3-5 hours.