Research in knockout mice has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Although your white blood cells account for only about 1 percent of your blood, their impact is significant. White blood cells, also called leukocytes, are essential for good health and protection against illness and disease. Think of white blood cells as your immunity cells.
Neutrophils. According to the 'Oxford Handbook of Clinical Medicine, neutrophils are the most abundant white blood cells, ranging between 2,000 and 7,500 per cubic mm of blood. About 55 to 75 percent of the total WBC count in the blood is made up of neutrophils. They play a crucial role in fighting infection.onocytes. Monocytes are the biggest in size among the five types of white blood cells. Their numbers in blood fall between 200 and 800 per cubic mm of blood, accounting for about 5 to 8 percent of the total WBC count.