The Board of Regents named Dr. Steve Wrigley the 13th chancellor of the University System of Georgia effective January 1, 2017. He oversees 26 public colleges and universities with a $8.8 billion annual budget, more than 48,000 faculty and staff, and 320,000 students.
Dornase alfa is a biosynthetic form of human DNase I. The enzyme is involved in endonucleolytic cleavage of extracellular DNA to 5Â´-phosphodinucleotide and 5Â´-phosphooligonucleotide end products.It has no effect on intracellular DNA.tudies in rats indicate that, following aerosol administration, the disappearance half-life of dornase alfa from the lungs is 11 hours. In humans, sputum DNase levels declined below half of those detected immediately post-administration within 2 hours but effects on sputum rheology persisted beyond 12 hours.
Dornase alfa. Dornase alfa (Pulmozyme Â®) is a highly purified solution of recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA. Pulmozyme hydrolyzes the DNA in sputum/mucus of CF patients and reduces viscoelasticity in the lungs, promoting improved clearance of secretions.n this 1-year intervention study evaluating the effect of dornase alfa in children with mild CF lung disease, only the visual mucus plugging CT score at 1 year demonstrated significant differences between groups, with a continued decline in the dornase alfa group compared to an increase in the placebo group.