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Doxycycline is the drug of choice for Rocky Mountain spotted fever (RMSF). It inhibits protein synthesis and, consequently, bacterial growth by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria.
Rocky Mountain Spotted Fever Affects. The bacteria that cause RMSF are found in tick saliva. For a tick to infect pets with Rickettsia rickettsii, it typically must be attached to the dog for four to six hours. Once the bacteria enter the pet's body, they spread to the walls of the blood vessels and multiply.