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Doxycycline is the drug of choice for Rocky Mountain spotted fever (RMSF). It inhibits protein synthesis and, consequently, bacterial growth by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria.
What Is the Cause of Rocky Mountain Spotted Fever? RMSF is caused by R. rickettsii, which are bacteria that are Gram stain negative, aerobic coccobacilli (round and rod shaped) that must live within eukaryotic cells (cells, such as human cells, that have a nucleus bound by a membrane).