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The most common Topamax side effects when taken alone by adults with epilepsy are: 1  Tingling of the arms and legs. 2  Weight loss. 3  Sleepiness. A loss of appetite (anorexia) 4  Dizziness. Memory problems.
1 Topamax can cause kidney stones. 2  This risk is increased for people taking carbonic anhydrase inhibitors (see Topamax Drug Interactions) or people following a ketogenic diet. 3  It is important to drink plenty of fluids to help prevent kidney stones. It is important to drink plenty of fluids to help prevent kidney stones. 2  One of the most common Topamax side effects is paresthesia (unusual sensations, such as burning, tingling, or pricking).