Research in knockout mice has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Although your white blood cells account for only about 1 percent of your blood, their impact is significant. White blood cells, also called leukocytes, are essential for good health and protection against illness and disease. Think of white blood cells as your immunity cells.
The lymphocytes form about 15 percent to 40 percent of the total number of white blood cells present in the body. A decrease or increase in the normal levels of lymphocytes is considered as abnormal and usually an indication of the presence of some infections or health conditions. When the percentage of lymphocytes that form the total number of white blood cells in the human body is lower than fifteen percent, then it signifies low levels of lymphocytes in the body.