Research in knockout mice has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Although your white blood cells account for only about 1 percent of your blood, their impact is significant. White blood cells, also called leukocytes, are essential for good health and protection against illness and disease. Think of white blood cells as your immunity cells.
White blood cells, also called the leukocytes, help fight off infections in your body. Normally you will have between 3,500 and 5,000 white blood cells per microliter of blood. Less than this is considered low. A low white blood cell count means your body's ability to fight off infections is compromised. Types White blood cells come in five types: basophils, eosinophils, lymphocytes, monocytes and neutrophils.