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Doxycycline is the drug of choice for Rocky Mountain spotted fever (RMSF). It inhibits protein synthesis and, consequently, bacterial growth by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria.
Rocky Mountain spotted fever (RMFS) is not contagious from person to person. The disease requires, in most instances, transfer of bacteria from the tick bite to the individual. Infrequently, some people can become infected with the bacteria if they contact tick droppings or crushed dead ticks.