How many words does a novel have to have to be published? How long should your novel be to be published? There is no simple answer to the question. Most adult novels are at least 60,000 words. The average adult fiction novel runs from 75,000 to 100,000 words.
Hello Lisagarmaise, Serotonin is to blame! Excessive release of 5HT(serotonin) from intestinal mucosa cells can cause diarrhea and nausea. Metformin stimulates these intestinal cells to produce increased levels of 5HT, as soon as 10-15 minutes after taking metformin. The good news is that most symptoms dissapear after taking metformin for 2-3 weeks.
Symptoms of lactic acidosis include weakness, sleepiness, slow heart beat, feeling cold, muscle pain, shortness of breath, loss of consciousness, etc. Although metformin does not directly cause kidney damage, the patients who have kidney damage and or kidney disease should not use the medicine. Another significant complication of metformin is Acute Kidney Failure. Gastrointestinal problems such as, significant diarrhea or vomiting commonly occur in people who are taking metformin therapy when there is underlying chronic kidney disease. It can lead to severe dehydration and acute renal failure.