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Doxycycline is the drug of choice for Rocky Mountain spotted fever (RMSF). It inhibits protein synthesis and, consequently, bacterial growth by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria.
Rocky Mountain spotted fever (RMSF) is the most serious tick-borne disease in the United States and is caused by Rickettsia rickettsii, a type of bacteria known as rickettsia. These bacteria are transmitted to humans by the bite of certain hard ticks.