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Answers. Best Answer: Alprazolam (xanax) has a half life of 6 - 12 hours so half of the drug will be gone in about 9 hours and then it will be down to a quarter of your dose in 18 hours etc. It should be completely undetectable within 3 - 5 days.
Like most drugs, Xanax has a limited duration once it is ingested. Normally, Xanax stays in a personâs system for approximately 6 hours. Depending on the personâs weight, that period can extend to 10 hours. If the person is morbidly obese or has liver problems Xanax can linger on in their system for about 40 hours.