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Answers. Best Answer: Alprazolam (xanax) has a half life of 6 - 12 hours so half of the drug will be gone in about 9 hours and then it will be down to a quarter of your dose in 18 hours etc. It should be completely undetectable within 3 - 5 days.
For the drug to be completely eliminated from your system, it should take around 5.5 times the half-life of the drug. The half-life of Xanax is about 11.2 hours, so it will be completely eliminated from the body about six days after the last dose. Only 1% of the drug leaves your system during urination. Even though Xanax dissipates from the system relatively quickly, the symptoms of withdrawal following Xanax abuse can last for months.