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The most common Topamax side effects when taken alone by adults with epilepsy are: 1  Tingling of the arms and legs. 2  Weight loss. 3  Sleepiness. A loss of appetite (anorexia) 4  Dizziness. Memory problems.
Users of Topamax have reported feelings of tiredness and fatigue while taking the medication. Another common side effect of Topamax is experiencing changes in the way foods and drinks taste. Topamax users have reported this side effect while drinking carbonated beverages.