Research in knockout mice has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Although your white blood cells account for only about 1 percent of your blood, their impact is significant. White blood cells, also called leukocytes, are essential for good health and protection against illness and disease. Think of white blood cells as your immunity cells.
WBC Count (or leukocyte count) WBC count is the number of white blood cells in the volume of blood. There are normally between 4Ã109 and 1.1Ã1010 white blood cells in a liter of blood, making up approximately 1% of blood in a healthy adult. This is also called leukocyte count and may be expressed as 4,000 to 11,000 cells per cubic millimeter (cmm).