Research in knockout mice has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Although your white blood cells account for only about 1 percent of your blood, their impact is significant. White blood cells, also called leukocytes, are essential for good health and protection against illness and disease. Think of white blood cells as your immunity cells.
Red blood cells (also called erythrocytes) make up about 40% of the blood's volume. Red blood cells contain hemoglobin, a protein that gives blood its red color and enables it to carry oxygen from the lungs and deliver it to all body tissues.hite blood cells (also called leukocytes) are fewer in number than red blood cells, with a ratio of about 1 white blood cell to every 600 to 700 red blood cells. White blood cells are responsible primarily for defending the body against infection. There are five main types of white blood cells.