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Antibiotics for Ear Infections: An Overview Many antibiotics are approved by the Food and Drug Administration (FDA) to fight otitis media (ear infections), although most doctors rely on a few favorites. Most antibiotics for ear infections fall under four families:  penicillins, cephalosporins, sulfonamides, and erythromycins. Amoxicillin is the most common antibiotic used to treat ear infections. When using antibiotics for ear infections, remember to take each dose on schedule.
Use clotrimazole to treat fungal infections in the ear. Clotrimazole 1% solution is the most popular antifungal medicine that doctors prescribe for the treatment of fungal ear infections. It kills both Candida and Aspergillus. This drug works by inhibiting the enzyme used to convert ergosterol.