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Answers. Best Answer: Alprazolam (xanax) has a half life of 6 - 12 hours so half of the drug will be gone in about 9 hours and then it will be down to a quarter of your dose in 18 hours etc. It should be completely undetectable within 3 - 5 days.
The mean plasma elimination half-life of Xanax is reported to be 11.2 hours. The full range is from 6.3 to 26.9 hours in healthy adults. For a drug to be totally eliminated from your system it takes 5.5 times the half life. If we take the maximum time of 26.9 hours times 5.5, it will be in your system for approximately 148 hours i.e. 6 days, after your final dose. https://www.drugs.com/pro/xanax.html.