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Vesicoureteral reflux (VUR) is characterized by the retrograde flow of urine from the bladder to the kidneys. VUR may be associated with urinary tract infection (UTI), hydronephrosis, and abnormal kidney development (renal dysplasia).
Urine flows from each kidney through tubes called ureters and into the bladder. When the bladder is full, it squeezes and sends the urine out through the urethra. No urine should flow back into the ureter when the bladder is squeezing. Each ureter has a one-way valve where it enters the bladder that prevents urine from flowing back up the ureter. But in some people, urine flows back up to the kidney. This is called vesicoureteral reflux. Over time, the kidneys may be damaged or scarred by this reflux. This is called reflux nephropathy. Reflux can occur in people whose ureters do not attach properly to the bladder or whose valves do not work well.