Research in knockout mice has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Although your white blood cells account for only about 1 percent of your blood, their impact is significant. White blood cells, also called leukocytes, are essential for good health and protection against illness and disease. Think of white blood cells as your immunity cells.
White blood cell. White blood cells (also called leukocytes or immune cells) are cells which form a component of the blood. They help to defend the body against infectious disease and foreign materials as part of the immune system. There are normally between 4x109 and 11x109 white blood cells in a litre of healthy adult blood - about 7,000 to 25,000 white blood cells per drop.