The outer circle of stars shall be so arranged that one star shall appear directly in the middle at the top of the circle, and the word Indiana shall be placed in a half circle over and above the star representing Indiana and midway between it and the star in the center above it.
Mutations in either nuclear DNA (nDNA) or mitochondrial DNA (mtDNA) can cause mitochondrial disease. Nuclear DNA is packaged into structures called chromosomesâ22 pairs of non-sex related chromosomes (called autosomes) and a single pair of sex chromosomes (XX in females and XY in males).
1 Mitochondrial dysfunction has been definitively linked to virtually all killer diseases of aging, from Alzheimerâs disease and type 2 diabetes to heart failure.  Researchers have recorded evidence of greater mitochondrial damage in the brain cells of humans over 70 compared to those in their early 40s.