Kuali Financial System. Become a KFS User. Make sure you have an Acceptable Use Agreement on file. If you have not completed one before, you can do so at: http://protect.iu.edu/agreement. Your department must submit a KFS System User Role document, located in the Chart of Accounts module of KFS.
A change in. the content of the genetic messageâthe base sequence of. one or more genesâis referred to as a mutation. Some mu-. tations alter the identity of a particular nucleotide, while. others remove or add nucleotides to a gene.
However, these mistakes are rare, and the cell has repair mechanisms that can repair some damage. - Sometimes a permanent change occurs in a cell's DNA and this is called a mutation. - Because a mutation in a gene causes a change in the protein that is made, the enzyme is nonfunctional. Types of mutations - Mutations can range from changes in a single base pair in the coding sequence of DNA to the deletions of large pieces of chromosomes. - Point mutations involve a chemical change in just one base pair and can be enough to cause a genetic disorder. - A point mutation in which one base is exchanged for another is called a substitution. - Most substitutions are missense mutations, where the DNA code is altered so that it codes for the wrong amino acid. - Other substitutions, called nonsense mutations, change the codon for an amino acid to a stop codon. Nonsense mutations cause translation to terminate early. Nearly all nonsense mutations lead to proteins that cannot function normally. - Another type of mutation that can occur involves the gain or loss of a nucleotide in the DNA sequence.