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Doxycycline is the drug of choice for Rocky Mountain spotted fever (RMSF). It inhibits protein synthesis and, consequently, bacterial growth by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria.
Rash caused by Rocky Mountain spotted fever. Although many people become ill within the first week after infection, signs and symptoms may not appear for up to 14 days. Initial signs and symptoms of Rocky Mountain spotted fever often are nonspecific and can mimic those of other illnesses: 1  High fever. 2  Chills. 3  Severe headache. 4  Muscle aches. 5  Nausea and vomiting.