Although aminoglycoside-induced nephrotoxicity is generally reversible following discontinuation of the drug, death from uremia has occurred rarely. Therapy with aminoglycosides should be administered cautiously at reduced dosages in patients with renal impairment, since they may be at increased risk for oto- and nephrotoxicity due to drug accumulation.
â Paul Wesley. Paul Thomas Wesley (Polish: PaweÅ Tomasz Wasilewski, born July 23, 1982) is a Polish-American actor who plays Stefan Salvatore, Tom Avery, Silas and Ambrose on The Vampire Diaries. He appeared on several TV shows such as The Guiding Light, Wolf Lake, Smallville, and Everwood.
1. Background. John Wesley was born in the rectory of Epworth, Lincolnshire to Samuel and Susannah Annesley Wesley on June 17, 1703. Several sources overwhelmingly indicate him as being the 15th child out of the total 19 conceived from this union. (Green; Heitzenrater; Tuttle; Tyerman; Edwards; Cell; Doughty).