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Antibiotics for Ear Infections: An Overview Many antibiotics are approved by the Food and Drug Administration (FDA) to fight otitis media (ear infections), although most doctors rely on a few favorites. Most antibiotics for ear infections fall under four families:  penicillins, cephalosporins, sulfonamides, and erythromycins. Amoxicillin is the most common antibiotic used to treat ear infections. When using antibiotics for ear infections, remember to take each dose on schedule.
Very effective for middle ear infection (otitis media). Augmentin is among the preferred beta-lactam antibiotics for the treatment of acute otitis media2. Animal and human bites. Because of its anaerobic coverage, Co-amoxiclav is an excellent drug for treating infections caused by human and animal bites.