What is canavan disease? Canavan deteriorates the white matter (myelin) in the brain. White  matter is responsible for forming a protective coating around every  nerve in the brain and spinal cord tâ¦o ensure that nerve impulses  are properly transmitted from one part of the body to another.
Pruning Knock OutÂ® Roses. June 12th, 2013. Prune your rose bush in early spring, never in the fall and never in the winter. Check your rose bush from time to time as spring moves along and when you start to see new shoots growing from the canes on your rose bush, thatâs a good sign that it is time to prune.
Single and double Knock Outs are hardy in U.S. Department of Agriculture plant hardiness zones 4 through 10 or zones 5 through 11, depending on the source. Pruning both kinds of Knock Out roses on a regular basis helps keep them healthy and shaped. Spring and Fall Pruning Single and double Knock Out roses benefit from an annual late-winter or early-spring pruning, whether they grow in cool or warm climates. Wait until the shrubs have had at least their second year of growth to prune them, however; they are mature then.