The Board of Regents named Dr. Steve Wrigley the 13th chancellor of the University System of Georgia effective January 1, 2017. He oversees 26 public colleges and universities with a $8.8 billion annual budget, more than 48,000 faculty and staff, and 320,000 students.
Dornase alfa is a biosynthetic form of human DNase I. The enzyme is involved in endonucleolytic cleavage of extracellular DNA to 5Â´-phosphodinucleotide and 5Â´-phosphooligonucleotide end products.It has no effect on intracellular DNA.tudies in rats indicate that, following aerosol administration, the disappearance half-life of dornase alfa from the lungs is 11 hours. In humans, sputum DNase levels declined below half of those detected immediately post-administration within 2 hours but effects on sputum rheology persisted beyond 12 hours.
Dornase alfa (Pulmozyme Â®) is a highly purified solution of recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA. Pulmozyme hydrolyzes the DNA in sputum/mucus of CF patients and reduces viscoelasticity in the lungs, promoting improved clearance of secretions.TABULAR DATA OMITTED]. Efficacy Outcomes/Results. Administration of dornase alfa significantly improved [FEV.sub.1], (Table 2, Fig 1). The mean percent change in [FEV.sub.1] in the dornase alfa group improved by 9.4% (96% CI, 6.81 to 11.96) compared with a 2.1% (CI, 0.07 to 4.18) improvement in the placebo group.