A weighted rein refers to a rein that is heavier on one or both ends. Naturally weighted reins are cut from hides that are specifically chosen for their weights and thicknesses. No extra leather or additional materials are added to the them. Notice in the picture the difference in the thicknesses of the tail, center and bit ends of this pair of reins.
Mitomycin C is a potent DNA crosslinker. A single crosslink per genome has shown to be effective in killing bacteria. This is accomplished by reductive activation of mitomycin to form a mitosene, which reacts successively via N-alkylation of two DNA bases.
Daptomycin is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms. It is a naturally occurring compound found in the soil saprotroph Streptomyces roseosporus. Its distinct mechanism of action makes it useful in treating infections caused by multiple drug-resistant bacteria. It is marketed in the United States under the trade name Cubicin by Cubist Pharmaceuticals.