Research in knockout mice has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Although your white blood cells account for only about 1 percent of your blood, their impact is significant. White blood cells, also called leukocytes, are essential for good health and protection against illness and disease. Think of white blood cells as your immunity cells.
The percentage of whole blood volume that is made up of red blood cells is called the hematocrit and is a common measure of red blood cell levels. back to top White Blood Cells (also called leukocytes) White blood cells protect the body from infection. They are much fewer in number than red blood cells, accounting for about 1 percent of your blood. The most common type of white blood cell is the neutrophil, which is the immediate response cell and accounts for 55 to 70 percent of the total white blood cell count. Each neutrophil lives less than a day, so your bone marrow must constantly make new neutrophils to maintain protection against infection.