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The most common Topamax side effects when taken with other medicines by children with epilepsy are: 1  Fatigue. 2  Sleepiness. 3  Lack of appetite (anorexia) 4  Nervousness. Problems concentrating or paying attention.  Memory 1  problems. Aggressiveness.  Weight loss.
Numbness and tingling. This is known as paresthesia and is the most common side effect of TOPAMAX. People have described this as numbness or pins and needles, most often in the arms or legs. More people had paresthesia during the early stage of treatment; however, it didn't stop most people from taking TOPAMAX.ther common TOPAMAX side effects are loss of appetite, nausea, and diarrhea. Your healthcare professional is the best person to talk with about your side effects and can adjust your dose of TOPAMAX if necessary.