What is canavan disease? Canavan deteriorates the white matter (myelin) in the brain. White  matter is responsible for forming a protective coating around every  nerve in the brain and spinal cord tâ¦o ensure that nerve impulses  are properly transmitted from one part of the body to another.
Pruning Knock OutÂ® Roses. June 12th, 2013. Prune your rose bush in early spring, never in the fall and never in the winter. Check your rose bush from time to time as spring moves along and when you start to see new shoots growing from the canes on your rose bush, thatâs a good sign that it is time to prune.
Winter rose pruning. For best results, rose pruning should take place in winter when the plant is in its dormant phase. Winter pruning should begin when the autumn leaf fall is complete and before new buds and leaves begin to appear on the rose plant. Immature roses that are not fully established should be pruned with great care and should receive less vigorous cutting-back than when you are pruning a mature plant.