Research has demonstrated that many individuals with Crohnâs ileitis share a genetic mutation that may play a significant role in disease development. A hypersensitive immuno-response to a pathogenic presence, such as bacteria, within the gastrointestinal tract is also suspected of contributing to the disease's onset.
Secondary osteoarthritis occurs less frequently than primary (also known as idiopathic) osteoarthritis. Primary osteoarthritis means that there is no known cause for the joint breakdown.
Abstract. Osteoarthritis (OA) is a common joint disease with complex etiology, including biomechanical, biochemical, and genetic components. The genetics of primary idiopathic OA is likely complex as multiple susceptibility loci have been identified from genome-wide scans.bstract. Osteoarthritis (OA) is a common joint disease with complex etiology, including biomechanical, biochemical, and genetic components. The genetics of primary idiopathic OA is likely complex as multiple susceptibility loci have been identified from genome-wide scans.