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Antibiotics for Ear Infections: An Overview Many antibiotics are approved by the Food and Drug Administration (FDA) to fight otitis media (ear infections), although most doctors rely on a few favorites. Most antibiotics for ear infections fall under four families:  penicillins, cephalosporins, sulfonamides, and erythromycins. Amoxicillin is the most common antibiotic used to treat ear infections. When using antibiotics for ear infections, remember to take each dose on schedule.
Most mild ear infections clear up without intervention. Some of the following methods are effective in relieving the symptoms of a mild ear infection: applying a warm cloth to the affected ear; taking over-the-counter pain medication such as ibuprofen or acetaminophen; using over-the-counter or prescription ear drops to relieve pain