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The most common Topamax side effects when taken alone by adults with epilepsy are: 1  Tingling of the arms and legs. 2  Weight loss. 3  Sleepiness. A loss of appetite (anorexia) 4  Dizziness. Memory problems.
Topamax Can Cause Worse Side Effects Than Older Anti-Seizure Drugs. From the WebMD Archives. May 16, 2003 -- Memory and other cognitive problems are more common among epilepsy patients taking the popular anti-seizure drug Topamax than in those taking an older mediation, new research suggests.