Research in knockout mice has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Although your white blood cells account for only about 1 percent of your blood, their impact is significant. White blood cells, also called leukocytes, are essential for good health and protection against illness and disease. Think of white blood cells as your immunity cells.
White blood cells, or leukocytes, are a part of the immune system. They help our bodies fight infection. White blood cells circulate in the blood so they can be transported to an area that has developed an infection. In normal adult bodies there are 4,000 to 10,000 (average 7,000) white blood cells per microliter of blood. If the number of white blood cells in your blood increases, it is a sign of an infection somewhere in the body. There are six main types of white blood cells: Neutrophils, which make up 58 percent of the blood.