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Doxycycline is the drug of choice for Rocky Mountain spotted fever (RMSF). It inhibits protein synthesis and, consequently, bacterial growth by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria.
Rocky Mountain Spotted Fever. Rocky Mountain spotted fever is considered the most severe tick-borne disease in the US, with a high mortality rate among untreated cases. RMSF has a disease presence in Florida, with the number of cases increasing in the summer months.The American dog tick is the main transmitter in Florida.he Centers for Disease Control and Prevention (CDC) has recently identified the brown dog tick as a vector for Rocky Mountain spotted fever (RMSF) in the southwestern United States and along the Mexican border.