Research has demonstrated that many individuals with Crohnâs ileitis share a genetic mutation that may play a significant role in disease development. A hypersensitive immuno-response to a pathogenic presence, such as bacteria, within the gastrointestinal tract is also suspected of contributing to the disease's onset.
Secondary osteoarthritis occurs less frequently than primary (also known as idiopathic) osteoarthritis. Primary osteoarthritis means that there is no known cause for the joint breakdown.
Primary generalized osteoarthritis affects women more than men, often occurring shortly after menopause. Most people with primary osteoarthritis have other family members who are affected by the same problem, and usually have swelling and or pain of the finger joints, base of the thumbs, and knees or hips.rimary generalized osteoarthritis affects women more than men, often occurring shortly after menopause. Most people with primary osteoarthritis have other family members who are affected by the same problem, and usually have swelling and or pain of the finger joints, base of the thumbs, and knees or hips.