Research has demonstrated that many individuals with Crohnâs ileitis share a genetic mutation that may play a significant role in disease development. A hypersensitive immuno-response to a pathogenic presence, such as bacteria, within the gastrointestinal tract is also suspected of contributing to the disease's onset.
Secondary osteoarthritis occurs less frequently than primary (also known as idiopathic) osteoarthritis. Primary osteoarthritis means that there is no known cause for the joint breakdown.
Although osteoarthritis is especially common in older adults, its pathology of asymmetric joint cartilage loss, subchondral sclerosis (increased bone density), marginal osteophytes and subchondral cysts is the same in younger and older adults.1 Primary osteoarthritis is the most common form and is usually seen in weight-bearing joints that have undergone abnormal stresses (e.g., from obesity or overuse).13 â 16 The precise etiology of osteoarthritis is unknown, but biochemical and ...