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Best Answer: Alcohol or ethanol affects the human nervous system by inhibiting signals between the brain, nerve endings and spinal cord. When people drink, their bloodstream absorbs the alcohol and nervous system functions slow down dramatically--this is the buzz or numbness people commonly feel after drinking.
Brain Chemical Imbalances after Long-Term Alcohol Use. Alcohol has widespread effects on the brain and can affect neurons (nerve cells), brain chemistry, and blood flow within the frontal lobes of the brain. Neurotransmitters (chemical messengers in the brain) are affected by long-term use of alcohol. When a person who is dependent on alcohol stops drinking, chemical responses create an overexcited nervous system and agitation by changing the level of chemicals that inhibit impulsivity or stress and excitation.