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Antibiotics for Ear Infections: An Overview Many antibiotics are approved by the Food and Drug Administration (FDA) to fight otitis media (ear infections), although most doctors rely on a few favorites. Most antibiotics for ear infections fall under four families:  penicillins, cephalosporins, sulfonamides, and erythromycins. Amoxicillin is the most common antibiotic used to treat ear infections. When using antibiotics for ear infections, remember to take each dose on schedule.
Antipyrine is a pain reliever. Benzocaine is a local anesthetic (numbing medicine). Antipyrine and benzocaine otic (for use in the ears) is a combination medicine used to treat pain and swelling caused by ear infections. This medicine does not contain an antibiotic and will not treat an ear infection.