What is canavan disease? Canavan deteriorates the white matter (myelin) in the brain. White  matter is responsible for forming a protective coating around every  nerve in the brain and spinal cord tâ¦o ensure that nerve impulses  are properly transmitted from one part of the body to another.
Pruning Knock OutÂ® Roses. June 12th, 2013. Prune your rose bush in early spring, never in the fall and never in the winter. Check your rose bush from time to time as spring moves along and when you start to see new shoots growing from the canes on your rose bush, thatâs a good sign that it is time to prune.
Then there is pruning tree roses as well as pruning knockout rose bushes. The signs for pruning rose bushes in the spring are the swelling of the rose buds. So therefore the best time to prune your roses is in early spring when those buds just begin to swell. Keep in mind that a rose is basically just a flowering shrub, and also that it's very hard to do any real harm to the rose bush if you do not prune like a pro the first time.