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A biopsy is the only way to diagnose non-Hodgkin lymphoma. There are several types of biopsies. Doctors choose which one to use based on each personâs situation. Excisional or incisional biopsy: This is the most common type of biopsy if lymphoma is suspected.any symptoms of non-Hodgkin lymphoma are not specific enough to say for certain if they are being caused by cancer. Most of them can also be caused by non-cancerous problems, like infections, or by other kinds of cancers.
Once non-Hodgkin lymphoma is diagnosed, tests are done to determine the stage (extent of spread) of the disease. The treatment and prognosis (outlook) for a patient with non-Hodgkin lymphoma depend in part on the stage of the lymphoma. Tests used to gather information for staging include:1  Physical exam. 2  Biopsies of enlarged lymph nodes or other abnormal areas. 3  Blood tests. 4  Imaging tests, such as CT scans. staging system is a way for members of a cancer care team to summarize the extent of a cancerâs spread. The Ann Arbor staging system is most often used to describe the extent of non-Hodgkin lymphoma in adults. The stages are described by Roman numerals I through IV (1-4).