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The most common Topamax side effects when taken alone by adults with epilepsy are: 1  Tingling of the arms and legs. 2  Weight loss. 3  Sleepiness. A loss of appetite (anorexia) 4  Dizziness. Memory problems.
Not everyone is guaranteed to lose weight on this medication. There is a lot of individual variation such as diet, habits, genetics, other medications, etc. that can have a huge impact on someoneâs weight. That said, it is estimated that weight loss is among the most common side effects of the drug Topamax.