Research in knockout mice has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus. This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Although your white blood cells account for only about 1 percent of your blood, their impact is significant. White blood cells, also called leukocytes, are essential for good health and protection against illness and disease. Think of white blood cells as your immunity cells.
Low Red Cell Count (Anemia). The bone marrow normally produces mature red blood cells and the hemoglobin in these cells carry oxygen to the tissues in your body. The percentage of red blood cells in the total blood volume is called the hematocrit.In healthy women the hematocrit is 36% to 46% while in healthy men the hematocrit is 40% to 52%.he bone marrow normally produces mature red blood cells and the hemoglobin in these cells carry oxygen to the tissues in your body. The percentage of red blood cells in the total blood volume is called the hematocrit. In healthy women the hematocrit is 36% to 46% while in healthy men the hematocrit is 40% to 52%.