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Sam is angry and blames Alexis for her brother's death. Before he dies, Danny tells Sam how glad he is that their parents chose her.. Sam has a DNA test done and it reveals that Danny was not her biological brother. She and Jason find records indicating that Sam was born to a 16 year old Alexis on May 11th, 1980.
Background. Sam was born to John and Mary Winchester on May 2, 1983. On November 2 in the same year, shortly after the baby Sam was put to bed for the night, Azazel came into his bedroom and fed the infant Sam his demon blood to make Sam one of Azazel's special children.