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The results of a trial suggest that combining pregabalin (Lyrica), an anti-seizure drug, with duloxetine (Cymbalta), an antidepressant, can safely improve outcomes in fibromyalgia, including not only pain relief, but also physical function and overall quality of life. Until now, these drugs have been proven, individually, to treat fibromyalgia pain.
Fibromyalgia: 7 Everyday Tasks Made Easier. Chronic pain is one of the most common reasons why people turn to alternative treatments like herbal and nutritional supplements. And these remedies may help ease fibromyalgia symptoms without uncomfortable drug side effects. Nausea and stomach irritation, for instance, have been associated with use of over-the-counter analgesic medicines, such as ibuprofen.