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Classifying lymphoma of the skin can be confusing (even for many doctors) because there are many types and they are not very common. The main system used to classify skin lymphoma is from the World Health Organization (WHO) and the European Organization for Research and Treatment of Cancer (EORTC) and is called the WHO-EORTC classification. It is based on: How the lymphoma looks under the microscope.
The B-cell lymphomas are types of lymphoma affecting B cells. Lymphomas are blood cancers in the lymph nodes. They develop more frequently in older adults and in immunocompromised individuals. B-cell lymphomas include both Hodgkin's lymphomas and most non-Hodgkin lymphomas. They are typically divided into low and high grade, typically corresponding to indolent (slow-growing) lymphomas and aggressive lymphomas, respectively.