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Haptoglobin, bilirubin, and liver function tests. When red blood cells break down, they release hemoglobin into the bloodstream. The hemoglobin combines with a chemical called haptoglobin. A low level of haptoglobin in the bloodstream is a sign of hemolytic anemia.
Low hemoglobin means that a person's hemoglobin level when measured, is below the lowest limits of normal for their age and sex (see above normal range of values). For example, a 19 year old male would have low hemoglobin if the detected blood value was below 13.6 g/dl. Another term frequently used in place of low hemoglobin is anemia, or the person is described as being anemic. Some of the more common causes of anemia are as follows: 1  Nutritional (iron, folic acid, or vitamin B 12 deficiency [ pernicious anemia ]).