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Haptoglobin, bilirubin, and liver function tests. When red blood cells break down, they release hemoglobin into the bloodstream. The hemoglobin combines with a chemical called haptoglobin. A low level of haptoglobin in the bloodstream is a sign of hemolytic anemia.
Anemia is defined as a hemoglobin level of less than 120 g/L in non-pregnant females and less than 130 g/L in males. Anemia is related to symptoms such as fatigue and lowered exercise tolerability. If your hemoglobin level is below 110 g/L, you should see your physician for further testing. If anemia is present, you should not return to donate until the cause of the low hemoglobin has been identified and corrected.