There was a significant delay in time to clinical worsening in the bosentan-treated group (hazard ratio 0.227, P = .0114) as shown in the Figure, a finding largely driven by a reduction in progression of symptomatic PAH in the bosentan-treated group (1%) vs the placebo group (10%).
Trading, on the other hand, involves the more frequent buying and selling of stock, commodities, currency pairs or other instruments, with the goal of generating returns that outperform buy-and-hold investing. While investors may be content with a 10 to 15% annual return, traders might seek a 10% return each month.
Trade or Business. A trade or business is generally an activity carried on for a livelihood or in good faith to make a profit. The facts and circumstances of each case determine whether or not an activity is a trade or business. The regularity of activities and transactions and the production of income are important elements. You do not need to actually make a profit to be in a trade or business as long as you have a profit motive. You do need, however, to make ongoing efforts to further the interests of your business.