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Haptoglobin, bilirubin, and liver function tests. When red blood cells break down, they release hemoglobin into the bloodstream. The hemoglobin combines with a chemical called haptoglobin. A low level of haptoglobin in the bloodstream is a sign of hemolytic anemia.
Common causes of higher indirect bilirubin include: Hemolytic anemia. This means your body is getting rid of too many red blood cells. Bleeding into the skin caused by injury. Bleeding in the lung caused by a blood clot. A gene problem that causes slightly higher indirect bilirubin levels without other signs or symptoms of disease