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Haptoglobin, bilirubin, and liver function tests. When red blood cells break down, they release hemoglobin into the bloodstream. The hemoglobin combines with a chemical called haptoglobin. A low level of haptoglobin in the bloodstream is a sign of hemolytic anemia.
1. Many causes: Anemia (low hemoglobin) can be a result of hypothyroidism through multiple mechanisms. Low thyroid causes less production of blood cells resulting in a normochromic anemia. It can also be associated with B12 deficiency and cause a macrocytic anemia. It can also cause less iron absorption and result in a microcytic anemia. If anemia persists after treating low thyroid, look other causes.