Give 1mg of Benadryl per pound such that if your dog weighs 30 pounds, you should give it 30 mg of Benadryl. Talk your veterinarian - while antihistamines are generally safe, there are the potential for side effects particularly if your dog has chronic organ failure (renal failure, liver failure, congestive heart failure, etc.).
1 Encephalitis is inflammation of the brain.  Meningitis is inflammation of the membranes (called meninges) that surround the brain and spinal cord.
Acute disseminated encephalomyelitis, or acute demyelinating encephalomyelitis, is a rare autoimmune disease marked by a sudden, widespread attack of inflammation in the brain and spinal cord. As well as causing the brain and spinal cord to become inflamed, ADEM also attacks the nerves of the central nervous system and damages their myelin insulation, which, as a result, destroys the white matter. It is often triggered after the patient has received a viral infection or, perhaps exceedingly rare