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The results of a trial suggest that combining pregabalin (Lyrica), an anti-seizure drug, with duloxetine (Cymbalta), an antidepressant, can safely improve outcomes in fibromyalgia, including not only pain relief, but also physical function and overall quality of life. Until now, these drugs have been proven, individually, to treat fibromyalgia pain.
Unfortunately, a majority of the psychiatric medications are known to cause weight gain and ultimately obesity. And some of these medications are used to treat chronic pain. There is clear evidence that weight gain is associated with mood stabilizers, antipsychotics and antidepressants.The tricyclic drugs, such as Elavil and Flexeril, have for years been used for chronic pain, including the pain of fibromyalgia.This class of drug has been shown to cause weight gain that is directly related to the dosage of the drug and the length of time a patient has been taking that drug.hese drugs include Prozac, which has been shown in clinical studies to be of benefit in fibromyalgia. As to why these drugs cause weight gain, one theory is that these medications may interfere with the part of the brain that regulates energy balance.