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Although the exact procedure may vary from product to product, the calibration process generally involves using the instrument to test samples of one or more known values called âcalibrators.â The results are used to establish a relationship between the measurement technique used by the instrument and the known values.
A calibration curve is one approach to the problem of instrument calibration; other approaches may mix the standard into the unknown, giving an internal standard.uch a curve is typically used when an instrument uses a sensor whose calibration varies from one sample to another, or changes with time or use; if sensor output is consistent the instrument would be marked directly in terms of the measured unit.