A sponsor seeking orphan designation for a drug must submit a request for designation to OOPD with the information required in 21 CFR 316.20 and 316.21. Each designation request must stand on its own merit.afety and effectiveness of a drug must be established through adequate and well-controlled studies. The Orphan Drug Act (ODA) provides for granting special status to a drug or biological product (âdrugâ) to treat a rare disease or condition upon request of a sponsor.
Missouri Valley, Harrison County, IA Foreclosures. Search for foreclosed homes for sale in Missouri Valley, Harrison County, Iowa.
Holt County, when first organized, embraced not only the present boundaries, but also Atchison County, that part of Nodaway lying west of the Nodaway River, and extended north ten miles into Iowa, as Missouri then claimed jurisdiction over a strip of country ten miles wide along the southern part of Iowa.