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Uday Devgan, M.D. T opical steroid use can have certain unwanted side effects. The main risks are a rise in intraocular pressure (IOP), posterior subcapsular cataracts, and increased infection.Increased pressure is a serious problem, as it could inadvertently give patients glaucoma.day Devgan, M.D. T opical steroid use can have certain unwanted side effects. The main risks are a rise in intraocular pressure (IOP), posterior subcapsular cataracts, and increased infection.
taking prednisone over long periods of time can cause a different set of side effects these long term side effects can include weight gain see prednisone and weight gain bulging eyes fluid retention osteoporosis acne loss of muscle stretch marks especially on the abdomen or stomach