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Uday Devgan, M.D. T opical steroid use can have certain unwanted side effects. The main risks are a rise in intraocular pressure (IOP), posterior subcapsular cataracts, and increased infection.Increased pressure is a serious problem, as it could inadvertently give patients glaucoma.day Devgan, M.D. T opical steroid use can have certain unwanted side effects. The main risks are a rise in intraocular pressure (IOP), posterior subcapsular cataracts, and increased infection.
Being a corticosteroid, prednisone may cause serious side effects if given for longer periods of time: 1  Secondary infections, which the dog is more susceptible to due to the suppressed immune system. 2  Increased thirst and appetite. 3  Fluid retention.  Hormonal irregularities, leading to acne, oily skin or dry, flaky 1  skin. Liver damage.  Kidney damage.