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Uday Devgan, M.D. T opical steroid use can have certain unwanted side effects. The main risks are a rise in intraocular pressure (IOP), posterior subcapsular cataracts, and increased infection.Increased pressure is a serious problem, as it could inadvertently give patients glaucoma.day Devgan, M.D. T opical steroid use can have certain unwanted side effects. The main risks are a rise in intraocular pressure (IOP), posterior subcapsular cataracts, and increased infection.
Other common prednisone side effects may include: 1  sleep problems (insomnia), mood changes; 2  increased appetite, gradual weight gain; 3  acne, increased sweating, dry skin, thinning skin, bruising or discoloration;  slow wound 1  healing; headache, dizziness, spinning sensation;  nausea, stomach pain, bloating; or.