A sponsor seeking orphan designation for a drug must submit a request for designation to OOPD with the information required in 21 CFR 316.20 and 316.21. Each designation request must stand on its own merit.afety and effectiveness of a drug must be established through adequate and well-controlled studies. The Orphan Drug Act (ODA) provides for granting special status to a drug or biological product (âdrugâ) to treat a rare disease or condition upon request of a sponsor.
Missouri Valley, Harrison County, IA Foreclosures. Search for foreclosed homes for sale in Missouri Valley, Harrison County, Iowa.
Community Census Data. Ozark is part of the Springfield Metro Area located in Greene and Christian Counties, Missouri. The Springfield Metro Area is comprised of Greene, Christian, Webster, Polk, and Dallas counties and has a population of over 430,000 people. Since 1990 the metro area's average growth rate has been 2.3%. Christian County is one of the fastest growing counties in the state, which can be seen in this graphic from the Columbia Missourian newspaper. The data, originally from the U.S. Census Bureau, shows national and local growth in America.