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Classifying lymphoma of the skin can be confusing (even for many doctors) because there are many types and they are not very common. The main system used to classify skin lymphoma is from the World Health Organization (WHO) and the European Organization for Research and Treatment of Cancer (EORTC) and is called the WHO-EORTC classification. It is based on: How the lymphoma looks under the microscope.
Types of Cutaneous B-Cell Lymphoma. Primary Cutaneous Follicle Center Lymphoma is the most common type of CBCL. These skin lymphomas develop slowly over months or years. They usually appear on the head, neck, or torso of the body as a red-brown pimply rash or nodules. Primary Cutaneous Marginal Zone B-cell Lymphoma is the second most common form of CBCL. This slow-growing lymphoma appears as pink or red lesions, nodules, and/or tumors, most commonly found on the torso or arms. Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg-type is less common than other CBCLs, but is usually more aggressive (fast-growing), developing over weeks or months.