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Uday Devgan, M.D. T opical steroid use can have certain unwanted side effects. The main risks are a rise in intraocular pressure (IOP), posterior subcapsular cataracts, and increased infection.Increased pressure is a serious problem, as it could inadvertently give patients glaucoma.day Devgan, M.D. T opical steroid use can have certain unwanted side effects. The main risks are a rise in intraocular pressure (IOP), posterior subcapsular cataracts, and increased infection.
Prednisone/Prednisolone may result in these side effects: 1  Increased drinking and urination. 2  Altered behavior. 3  Inhibited growth in young pets.  Diabetes after prolonged 1  use. Cushingâs disease after prolonged 2  use. Panting. 3  Vomiting. Diarrhea.  Ulceration of the 1  digestive tract. 2  Lethargy. Aggression.  Delayed healing.