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The results of a trial suggest that combining pregabalin (Lyrica), an anti-seizure drug, with duloxetine (Cymbalta), an antidepressant, can safely improve outcomes in fibromyalgia, including not only pain relief, but also physical function and overall quality of life. Until now, these drugs have been proven, individually, to treat fibromyalgia pain.
Naltrexone therapy for fibromyalgia involves using a consistent low dose of the drug to treat symptoms. Larger doses are given to people to help them manage opioid addiction. But low doses help people manage chronic pain. And doctors are testing the use of low dose naltrexone (LDN) as a treatment for fibromyalgia.