Best Answer: Chordata refers to the presence of a nerve chord running from the head to the back, which may or may not be accompanied by vertebrae. All animals with backbones are members of the chordate phylum, but not all chordates have bones (lancelets and tunicates are chordates lacking real bones).
Angelman syndrome (AS) is a genetic disorder that causes developmental delay, intellectual disability, speech problems, seizures (epilepsy), and problems with movement and balance (ataxia).ngelman syndrome (AS) is a severe neurodevelopmental disorder caused by maternal deficiency of the imprinted gene UBE3A. Individuals with AS suffer from intellectual disability, speech impairment, and motor dysfunction. Currently there is no cure for the disease.
Angelman syndrome is caused by the loss of the normal maternal contribution to a region of chromosome 15, most commonly by deletion of a segment of that chromosome. Other causes include uniparental disomy, translocation, or single gene mutation in that region.owever, in the region of the chromosome that is critical for Angelman syndrome, the maternal and paternal contribution express certain genes very differently. This is due to sex-related epigenetic imprinting; the biochemical mechanism is DNA methylation.