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He called for the north to secede from the Union to sever the ties with the slaveholding south. William Lloyd Garrison lived long enough to see the Union come apart under the weight of slavery. He survived to see Abraham Lincoln issue the Emancipation Proclamation during the Civil War.
For the entire generation of people that grew up in the years that led to the Civil War, William Lloyd Garrison was the voice of Abolitionism. Originally a supporter of colonization, Garrison changed his position and became the leader of the emerging anti-slavery movement.