The TARDBP gene provides instructions for making a protein called transactive response DNA binding protein 43 kDa (TDP-43). This protein is found within the cell nucleus in most tissues and is involved in many of the steps of protein production.
Jess Mariano is a recurring character on CW drama Gilmore Girls. He is portrayed by Milo Ventimiglia. Jess is the troubled love-interest of Rory Gilmore, son of Liz Danes and Jimmy Mariano, and nephew of Luke Danes. Jess is incredibly smart, quick-witted, and interested in the arts, but not academically motivated.
1 Hugh Jackman is now everywhere.  A whole host of actresses turned down the lead role in Pretty Woman (including Molly Ringwald, Meg Ryan, Michelle Pfeiffer, Jennifer Connelly, Karen Allen, and Winona Ryder). Julia Roberts was eventually given the part and it help solidify her growing stardom.