1 Joan, Princess of Wales, in the 13th century, the wife and consort of Llywelyn the Great, the Prince of Wales; and the daughter of King John of England. Joan, Princess of Wales, in the 13th century, the wife and consort of Llywelyn the Great, the Prince of Wales; and the daughter of King John of England.
1 More than 90% of COPD deaths occur in low- and middle-income countries. 2  The primary cause of COPD is tobacco smoke (through tobacco use or second-hand smoke).  The disease now affects men and women almost equally, due in part to increased tobacco use among women in high-income countries.
Nicotine itself is not especially harmful, apart from being an addictive drug. However, the chemicals associated with nicotine intake, whether smoking or smokeless, cause a variety of diseases including lung cancer, mouth cancer, heart disease, emphysema and chronic obstructive pulmonary disease (COPD). 9 people found this useful.