Richard Gere and Julia Roberts had obvious chemistry upon their first meeting. However, Richard was not planning on taking the role. He was on the phone ready to turn down the part when Julia slid him a post-it note with the words please say yes written on it.
Without life-sustaining dialysis or a kidney transplant, once a person with kidney disease reaches Stage 5 (end stage renal disease (ESRD)), toxins build up in the body and death usually comes within a few weeks. The decision to stop treatment should be an informed and voluntary choice.
In general, the more ill a patient is during the onset of renal failure, the worse the outcome. Severe cases of acute renal failure can result in death. On long-term follow-up (1 to 10 years), approximately 12.5% of survivors of acute renal failure require dialysis and 19% to 31% of them have chronic kidney disease. The in-hospital mortality (death) rate for acute kidney failure is 40% to 50%.