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The push-up requires many muscle groups, but the primary muscle groups are the chest muscles, the pectoralis major and minor. These are the two large chest muscles and mainly the pushing muscle group of the upper body. When pushing and lowering the body during a push up, the pectoralis major is doing most of the work.
Performing push-ups works a variety of muscles in your upper body, including specific muscles within your abdomen, chest, shoulders and upper arms. You can vary your technique by placing your hands at different widths to emphasize one area over another.