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By Mayo Clinic Staff. Most leg pain results from wear and tear, overuse, or injuries in joints or bones or in muscles, ligaments, tendons or other soft tissues. Some types of leg pain can be traced to problems in your lower spine. Leg pain can also be caused by blood clots, varicose veins or poor circulation. Some common causes of leg pain include: Achilles tendinitis. Achilles tendon rupture. Ankylosing spondylitis. ACL injury (Anterior cruciate ligament injury) Baker's cyst. Bone cancer.
Symptoms & Signs. Pain in the legs can occur as a result of conditions that affect bones, joints, muscles, tendons, ligaments, blood vessels, nerves, or skin. Leg pain can occur in the foot, ankle, knee, behind the knee, thigh, down the back of the leg, or in any part of the leg. It can occur at night, while lying down, or while running or exercising, depending upon the cause. Typically, the leg pain is a result of tissue inflammation that is caused by injury or disease. Either injury or chronic disease can cause inflammation to any of the tissues of the leg and lead to leg pain.