1 Joan, Princess of Wales, in the 13th century, the wife and consort of Llywelyn the Great, the Prince of Wales; and the daughter of King John of England. Joan, Princess of Wales, in the 13th century, the wife and consort of Llywelyn the Great, the Prince of Wales; and the daughter of King John of England.
1 More than 90% of COPD deaths occur in low- and middle-income countries. 2  The primary cause of COPD is tobacco smoke (through tobacco use or second-hand smoke).  The disease now affects men and women almost equally, due in part to increased tobacco use among women in high-income countries.
1 Using smokeless tobacco increases the risk for death from heart disease and stroke. 2  1,3. 3  Smokeless tobacco can cause nicotine poisoning in children. 4. 4  Additional research is needed to examine long-term effects of newer smokeless tobacco products, such as dissolvables and U.S. snus.ther Risks. 1  Using smokeless tobacco increases the risk for death from heart disease and stroke. 2  Smokeless tobacco can cause nicotine poisoning in children. 4. 3  Additional research is needed to examine long-term effects of newer smokeless tobacco products, such as dissolvables and U.S. snus.