The TARDBP gene provides instructions for making a protein called transactive response DNA binding protein 43 kDa (TDP-43). This protein is found within the cell nucleus in most tissues and is involved in many of the steps of protein production.
(CNN)Sookie St. James, say it isn't so! Superstar comedian Melissa McCarthy says she wasn't asked to return to the Netflix revival of Gilmore Girls, the show on which she played the super-talented chef sidekick to Lauren Graham's character, Lorelai Gilmore. McCarthy may be the best-known graduate of Gilmore Girls, which premiered in 2000 and aired for seven years.
1 Hugh Jackman is now everywhere.  A whole host of actresses turned down the lead role in Pretty Woman (including Molly Ringwald, Meg Ryan, Michelle Pfeiffer, Jennifer Connelly, Karen Allen, and Winona Ryder). Julia Roberts was eventually given the part and it help solidify her growing stardom.