The TARDBP gene provides instructions for making a protein called transactive response DNA binding protein 43 kDa (TDP-43). This protein is found within the cell nucleus in most tissues and is involved in many of the steps of protein production.
Jess Mariano is a recurring character on CW drama Gilmore Girls. He is portrayed by Milo Ventimiglia. Jess is the troubled love-interest of Rory Gilmore, son of Liz Danes and Jimmy Mariano, and nephew of Luke Danes. Jess is incredibly smart, quick-witted, and interested in the arts, but not academically motivated.
In 2000, McCarthy landed her breakthrough role on the popular WB show Gilmore Girls, providing a nuanced, fun and captivating portrayal of the character Sookie St. James, a chef who's the best friend of Lorelai Gilmore (Lauren Graham).