Hyperphosphatemia, that is, an abnormally high serum phosphate level, can result from increased phosphate (PO4) intake, decreased phosphate excretion, or a disorder that shifts intracellular phosphate to extracellular space. (See Pathophysiology, Etiology, Clinical Presentation, and Workup.)
Location is a major part of geography, which is a subject that looks at the physical features of the Earth and its atmosphere. Even when we consider elements of human geography, we think about those things with reference to location.
The difference between a sea and a lake largely comes down to permanence. A sea is a more permanent feature, while a lake is relatively temporary. This time frame is relative, and should be examined on a scale of millions of years. On a geological scale that includes and measures other massive, slow events such as ice ages and plate shifts, a lake is a temporary feature.