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The push-up requires many muscle groups, but the primary muscle groups are the chest muscles, the pectoralis major and minor. These are the two large chest muscles and mainly the pushing muscle group of the upper body. When pushing and lowering the body during a push up, the pectoralis major is doing most of the work.
How Push-Ups Build More Muscle. Logic says the push-up won't build strength unless you're kind of weak to begin with. Its benefits lie elsewhere. If you do push-ups correctly, you develop your scapular muscles and your rotator-cuff muscles to stabilize your shoulders. If you do bench presses instead of push-ups, you don't have to use those muscles as much, says Michael Clark, C.S.C.S., a physical therapist and president of the National Academy of Sports Medicine.