Normal extinction of species that occurs as a result of changes in local environmental conditions.
Verapamil Uses: An Overview. 1  High blood pressure (hypertension). 2  Chest pain (angina), including: 3  Vasospastic angina (Prinzmetal's angina or variant angina). 4  Unstable angina. 5  Chronic stable angina (exertional angina). 6  Certain irregular heart rhythms (arrhythmias), including: 7  Chronic atrial flutter.
Colchicine is a substrate for both CYP3 A and the efflux transporter, P-gp. Verapamil is known to inhibit CYP3A and P-gp. When verapamil and colchicine are administered together, the potential inhibition of P-gp and/or CYP3A by verapamil may lead to increased exposure to colchicine (see PRECAUTIONS-DRUG INTERACTIONS).