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The results of a trial suggest that combining pregabalin (Lyrica), an anti-seizure drug, with duloxetine (Cymbalta), an antidepressant, can safely improve outcomes in fibromyalgia, including not only pain relief, but also physical function and overall quality of life. Until now, these drugs have been proven, individually, to treat fibromyalgia pain.
Flexeril is one of the first medications that I was prescribed for my Fibro back in 1995 when I got diagnosed. It was thought to help me sleep deeper (get to stage 4 sleep) as well as reduce muscle spasms. Over the years I have rotated with other muscle relaxers (Robaxin and Skelaxin), and they have all helped greatly.