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Although many medications are used in Advanced life support, the only medication with proven efficacy in pediatric resuscitation is epinephrine. Despite numerous investigations, the optimal dose remains controversial.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric patients less than 6 years of age. Concomitant administration of promethazine products with other respiratory depressants has an association with respiratory depression, and sometimes death, in pediatric patients.