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The results of a trial suggest that combining pregabalin (Lyrica), an anti-seizure drug, with duloxetine (Cymbalta), an antidepressant, can safely improve outcomes in fibromyalgia, including not only pain relief, but also physical function and overall quality of life. Until now, these drugs have been proven, individually, to treat fibromyalgia pain.
Cyclobenzaprine may be helpful for sleep and pain control in fibromyalgia. The usual starting dose is 5-10 mg taken at bedtime. The dose may be increased to 20-30 mg, taken either at night or in divided doses during the day. Compared with amitriptyline, cyclobenzaprine is associated with better patient acceptance due to fewer side effects and more rapid onset of relief.