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Although many medications are used in Advanced life support, the only medication with proven efficacy in pediatric resuscitation is epinephrine. Despite numerous investigations, the optimal dose remains controversial.
1 Closed Epiphyses: Somatropin should not be used for growth promotion in pediatric patients with closed epiphyses. 2  Hypersensitivity: Humatrope is contraindicated in patients with a known sensitivity to somatropin or the supplied diluent.3  Localized reactions are the most common hypersensitivity reactions. Prader-Willi Syndrome in Children: Somatropin should not be used in pediatric patients with Prader-Willi syndrome who are severely obese, have a history of upper airway obstruction or sleep apnea, or have severe respiratory impairment. 2  There have been reports of sudden death when somatropin was used in such patients.