Broccoli and cauliflower are good sources of choline, a B vitamin known for its role in brain development. Choline intake during pregnancy super-charged the brain activity of animals in utero, indicating that it may boost cognitive function, improve learning and memory,
Methotrexate is a prescription medication used to treat certain types of cancers. It is also used to treat psoriasis, polyarticular juvenile idiopathic arthritis (PJIA), and rheumatoid arthritis (RA).Methotrexate belongs to a group of drugs called antimetabolites.ral/Injectable: Methotrexate is a prescription medication used to treat the following conditions: 1  severe psoriasis. 2  rheumatoid arthritis. 3  polyarticular juvenile idiopathic arthritis (PJIA). 4  breast cancer. 5  certain types of head and neck cancer. 6  lung cancer. 7  advanced non-Hodgkin lymphoma (NHL).
Drug: F8IL10 in combination with methotrexate. Weekly administration of F8IL10 (from 6 to 600 Î¼g/kg) + MTX (10-15 mg, fixed dose) on Day 1 and Folic acid (5 mg, fixed dose) on Day 2. Patients will receive 4 cycles of 1 week treatment unless there is an unacceptable toxicity or withdrawal of the informed consent. F8IL10 will be administered intravenously. MTX can be administered orally, subcutaneously or intramuscularly. Folic acid will be administered orally.