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1 For a medium rare roast: Cook the roast for 20 minutes for every pound. 2  If you were cooking a 5 pound roast, you would cook it for 100 minutes. 3  For a medium roast: Allow 22 minutes of cooking time for every pound.
When smoking roast beef, the thickness of your roast will determine how long it needs to cook. In general, cook on high for no more than 20 minutes per pound, but youâll probably want to turn the temperature gauge to 2/3 along the way. Check it after a couple of hours regardless, because it might get done faster.