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The results of a trial suggest that combining pregabalin (Lyrica), an anti-seizure drug, with duloxetine (Cymbalta), an antidepressant, can safely improve outcomes in fibromyalgia, including not only pain relief, but also physical function and overall quality of life. Until now, these drugs have been proven, individually, to treat fibromyalgia pain.
Aspirin, butalbital, and caffeine, are used together in an oral preparation to treat pain, specifically headaches. Aspirin is a non-narcotic analgesic for pain and headache relief. Butalbital is a barbiturate used for its sedative effects. Caffeine is found in many analgesic formulations and may be beneficial in Migraine and vascular headaches. Fiorinal is also available with codeine.