Communication of information between neurons is accomplished by movement of chemicals across a small gap called the synapse. Chemicals, called neurotransmitters, are released from one neuron at the presynaptic nerve terminal.
Follow Trail 12 until it runs back into trail 1 and familiar sights and then you are only about 200 yards from the great Cumberland Falls. To the best of my guessing ability I would say this loop was about 8.5 miles long which took us about 3 hours and 45 minutes.
At 1.4 miles the trail passes Midnight Hole, a deep, picturesque pool below a 6' falls. At 2.1 miles a short side trail on the left leads to a bench where hikers can rest and view Mouse Creek Falls which is on the far side of Big Creek. The falls are 45â in height. Trailhead: Exit I-40 at Waterville Road (#451).