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Haptoglobin, bilirubin, and liver function tests. When red blood cells break down, they release hemoglobin into the bloodstream. The hemoglobin combines with a chemical called haptoglobin. A low level of haptoglobin in the bloodstream is a sign of hemolytic anemia.
1 High levels of bilirubin can cause jaundice (yellowing of the skin and eyes, darker urine, and lighter-colored bowel movements). 2  Elevated bilirubin levels can be caused by reasons other than liver disease.3  Total bilirubin is made up of 2 components: direct bilirubin and indirect bilirubin. When bilirubin levels remain high for prolonged periods, it usually means there is severe liver disease and possibly cirrhosis. 2  High levels of bilirubin can cause jaundice (yellowing of the skin and eyes, darker urine, and lighter-colored bowel movements).