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Uday Devgan, M.D. T opical steroid use can have certain unwanted side effects. The main risks are a rise in intraocular pressure (IOP), posterior subcapsular cataracts, and increased infection.Increased pressure is a serious problem, as it could inadvertently give patients glaucoma.day Devgan, M.D. T opical steroid use can have certain unwanted side effects. The main risks are a rise in intraocular pressure (IOP), posterior subcapsular cataracts, and increased infection.
However, the high dose of prednisone can cause side effects such as enlarged pot belly appearance to the abdomen, and panting. Prednisone doses are usually decreased gradually over time to the least effective dose (lowest dose in which a benefit is still seen).