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1 For a medium rare roast: Cook the roast for 20 minutes for every pound. 2  If you were cooking a 5 pound roast, you would cook it for 100 minutes. 3  For a medium roast: Allow 22 minutes of cooking time for every pound.
Plan to cook the roast for 12 to 15 minutes per pound at 350 F, so a 7 pound roast, for example, needs about 1 hour and 20 minutes. Use a meat thermometer to help you determine doneness.