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At onset of muscle contraction, myoglobin (Mb) immediately releases its bound O 2 to the mitochondria. Accordingly, intracellular O 2 tension (P mb O 2) markedly declines in order to increase muscle O 2 uptake (m O 2).t onset of muscle contraction, myoglobin (Mb) immediately releases its bound O 2 to the mitochondria. Accordingly, intracellular O 2 tension (P mb O 2) markedly declines in order to increase muscle O 2 uptake (m O 2).
Myoglobin is the primary oxygen-carrying pigment of muscle tissue. It is high when muscle tissue is damaged but it lacks specificity. It has the advantage of responding very rapidly, rising and falling earlier than CK-MB or troponin. It also has been used in assessing reperfusion after thrombolysis.