uk â /ËhaÉªÉrÉËki/ us â plural hierarchies. âº a system in which the people within a company or organization are organized into levels according to the authority they have: Every organization has a hierarchy, and trying to understand that, and the systems and processes of the organization, is important. corporate/management/organizational/political, etc. hierachy Many kinds of work are more easily and cheaply managed in corporate hierarchies than by individuals doing deals in the market.
The most common cause of acute histamine toxicity is the result of inadequate refrigeration or spoiled fish. This causes an overgrowth of bacteria which converts histidine to high levels of histamine. Individuals who have unusually low levels of the enzyme diamine oxidase may be more susceptible to histamine toxicity.
When the histamine arrives at the site of irritation, it causes several important effects. One is the dilating, or widening, of small blood vessels in that area. This is known as an inflammatory response, or swelling. Swelling increases the flow of blood to the area.