Cristiano Ronaldo is highest-paid player, Lionel Messi second - Forbes. Real Madrid remain the most valuable football team in the world for a fourth consecutive year, according to Forbes. Cristiano Ronaldo was the world's highest-paid footballer -- and highest-paid team athlete -- last year, according to US business magazine Forbes. Real Madrid star Ronaldo was said to have earned a total of $82 million (Â£56.7m), with an annual salary of $53m (Â£36.7m) and $29m (Â£20m) in endorsements.
A chromosome deletion is also possible, where an entire section of a chromosome is deleted. Diseases that can be caused by deletion mutation can include 22q11.2 deletion syndrome, cystic fibrosis, Turner syndrome, and Williams syndrome.
The earlier in the sequence the deletion or insertion occurs, the more altered the protein. A frameshift mutation is not the same as a single-nucleotide polymorphism in which a nucleotide is replaced, rather than inserted or deleted. A frameshift mutation will in general cause the reading of the codons after the mutation to code for different amino acids. The frameshift mutation will also alter the first stop codon (UAA, UGA or UAG) encountered in the sequence.