Depot injection. A depot injection is an injection, usually subcutaneous, intradermal, or intramuscular, that deposits a drug in a localized mass, called a depot, from which it is gradually absorbed by surrounding tissue. Such injection allows the active compound to be released in a consistent way over a long period.
The Vanquish TM is a tunable, focused bipolar radiofrequency device which is FDA-approved for deep tissue heating. The deep tissue heating preferentially focuses in on the fat layer, and causes it to shrink by causing most of the fat cells to die off.
Basaglar was not approved as a biosimilar because there are no insulin glargines currently licensed under the PHSA. Lantus, its reference product, was approved under a different law, the Federal Food, Drug, and Cosmetic Act, an FDA spokesperson told Medscape Medical News. Instead, the FDA calls Basaglar an example of a follow-on product. More information on the FDA's decision is available on the agency's website.