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Diagram showing the basic physiologic mechanisms of the kidney. Renal function, in nephrology, is an indication of the state of the kidney and its role in renal physiology. Glomerular filtration rate (GFR) describes the flow rate of filtered fluid through the kidney. Creatinine clearance rate (CCr or CrCl) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR.
Chronic kidney disease (CKD) comes in stages and knowing your stage is important for deciding treatment. CKD has five stages, ranging from nearly normal kidney function (stage 1) to kidney failure (stage 5), which requires dialysis or kidney transplant. Understanding your stage can help you learn how to take control and slow the progression of kidney disease. The stages of renal disease are not based on symptoms alone. Instead, they reflect how effectively the kidneys eliminate waste from the blood by using an equation that estimates kidney function, known as glomerular filtration rate (GFR).