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Diagram showing the basic physiologic mechanisms of the kidney. Renal function, in nephrology, is an indication of the state of the kidney and its role in renal physiology. Glomerular filtration rate (GFR) describes the flow rate of filtered fluid through the kidney. Creatinine clearance rate (CCr or CrCl) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR.
Kidneys are the most important organs of the excretory system. The function of the kidney is to clean from the blood substances not needed in the body. The kidney is a complex filter, where active and passive mechanisms are involved as well as several complex control mechanisms.