Borderline personality disorder (BPD) is a serious mental illness that can be challenging for everyone involved, including the individuals with the illness, as well their friends and family members.
Acute CCK2 receptor blockade inhibits gastrin-evoked but not histamine-induced acid secretion. Studies both in vivo/in situ and in vitro have suggested that while acetylcholine seems capable of activating parietal cells, it does not affect histamine secretion from ECL cells.astric acid secretion is under nervous and hormonal control. Gastrin, the major circulating stimulus of acid secretion, probably does not stimulate the parietal cells directly but acts to mobilize histamine from the ECL cells in the oxyntic mucosa. Histamine stimulates the parietal cells to secrete HCl.
Histamine affects several receptors found in different tissues. Sometimes blocking the receptor and sometimes adding to it. Smooth muscle around bronchi in the lungs and within the intestinal tract respond to histamine stimulation by contraction, although the magnitude of response varies considerably among species. These effects also depend on which receptor is being bound by histamine; for example, the H2 receptor mediates bronchodilation.