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Distribution of edema: Unilateral. leg edema is generally due to a local cause such as deep vein thrombosis, venous insufficiency, or lymphedema. Bilateral. edema can be due to a local cause or systemic disease, such as heart failure or kidney disease. Generalized. edema is due to systemic disease.
Edema may be caused by: 1  Increased capillary hydrostatic pressure (as occurs when venous pressures become elevated by gravitational forces, volume expanded states, in heart failure or with venous obstruction)  Decreased plasma oncotic pressure (as occurs with hypoproteinemia)