Polypharmacy, very common in the elderly, and the possibility of drug-drug interactions must be considered as a cause of agitation. Medications such as benzodiazepines, beta-blockers, selective serotonin reuptake inhibitors (SSRIs), neuroleptics and diphenhydramine can cause problems.
Sun Damage. Overexposure is one of the main factors in scalp wrinkles (and wrinkles elsewhere, too). UV radiation speeds the breakdown of elastin and collagen, two things that keep skin tight and firm. As these degenerate, skin begins to sag and wrinkle.
Sores, blisters, or bumps on the scalp. Painful sores, blisters, or bumps that develop on the scalp may be caused by: Infection of the hair shafts (folliculitis) or the skin (such as impetigo). An allergic skin reaction (contact dermatitis). Viral infections, such as chickenpox and shingles.