Another SERM, raloxifene (Evista), is designed to mimic the effect of estrogen on the skeletal structure and serum lipids but, unlike tamoxifen, acts as a complete estrogen antagonist in the breast and endometrium.
When a domain is newly registered, the nameservers are changed, or DNS changes are made, you can expect a propagation time up to 24 hours. This is because it takes time for the DNS to take effect across the internet.
Once this initial action potential is initiated, principally at the axon hillock, it propagates down the length of the axon. Under normal conditions, the action potential would attenuate very quickly due to the porous nature of the cell membrane.