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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
The Endoplasmic Reticulum. The endoplasmic reticulum (ER) is a network of membrane-enclosed tubules and sacs (cisternae) that extends from the nuclear membrane throughout the cytoplasm (Figure 9.1).The entire endoplasmic reticulum is enclosed by a continuous membrane and is the largest organelle of most eukaryotic cells.Its membrane may account for about half of all cell membranes, and the space enclosed by the ER (the lumen, or cisternal space) may represent about 10% of the total cell volume.he entire endoplasmic reticulum is enclosed by a continuous membrane and is the largest organelle of most eukaryotic cells. Its membrane may account for about half of all cell membranes, and the space enclosed by the ER (the lumen, or cisternal space) may represent about 10% of the total cell volume.