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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
The endoplasmic reticulum (ER) is an organelle in eukaryotes that forms an interconnected network of vesicles, tubules, and cisternae within cells.he endoplasmic reticulum (ER) is an organelle in eukaryotes that forms an interconnected network of vesicles, tubules, and cisternae within cells.