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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
The nucleus is surrounded by a pair of membranes called the nuclear envelope, which can be continuous in places with the membranes of the endoplasmic reticulum. The membranes of the nuclear envelope have interconnected pores that allow the exchange of substances with the cell's cytoplasm.