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Diagram showing the basic physiologic mechanisms of the kidney. Renal function, in nephrology, is an indication of the state of the kidney and its role in renal physiology. Glomerular filtration rate (GFR) describes the flow rate of filtered fluid through the kidney. Creatinine clearance rate (CCr or CrCl) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR.
As a person's kidney function declines due to damage or disease, the filtration rate decreases and waste products begin to accumulate in the blood. Chronic kidney disease (CKD) is associated with a decrease in kidney function that is often progressive.s a person's kidney function declines due to damage or disease, the filtration rate decreases and waste products begin to accumulate in the blood. Chronic kidney disease (CKD) is associated with a decrease in kidney function that is often progressive.