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Distribution of edema: Unilateral. leg edema is generally due to a local cause such as deep vein thrombosis, venous insufficiency, or lymphedema. Bilateral. edema can be due to a local cause or systemic disease, such as heart failure or kidney disease. Generalized. edema is due to systemic disease.
In these diseases, edema occurs primarily because of the body's retention of too much salt (sodium chloride). The excess salt causes the body to retain water, which then leaks into the interstitial tissue spaces, where it appears as edema. Medications also can cause pitting edema. The most common local conditions that cause edema are varicose veins and thrombophlebitis (inflammation of the veins) of the deep veins of the legs.