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It is safe to take penicillin while pregnant. Penicillin falls in the pregnancy category B. The medicine has been around for a long time and shows no adverse effect on pregnant women. Doctors usually prescribe penicillin to treat strep throat or a UTI.
Acute cystitis and pyelonephritis should be aggressively treated during pregnancy. Oral nitrofurantoin and cephalexin are good antibiotic choices for treatment in pregnant women with asymptomatic bacteriuria and acute cystitis, but parenteral antibiotic therapy may be required in women with pyelonephritis.