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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
The endoplasmic reticulum is a membrane system of folded sacs and interconnected channels that serves as a site for protein and lipid synthesis. The various folds of the endoplasmic reticulum provide a large surface where cellular functions can take place. There are two types of endoplasmic reticulum: smooth and rough. Rough endoplasmic reticulum is a form of endoplasmic reticulum that is studded with ribosomes. Since it has ribosomes stuck all over it, it has a bumpy appearance and is therefore called rough endoplasmic reticulum.