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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
The endoplasmic reticulum (ER) is an organelle that has essential roles in multiple cellular processes that are required for cell survival and normal cellular functions. These processes include intracellular calcium homeostasis, protein secretion and lipid biosynthesis.everal of the proposed regulators of basal concentrations of calcium in the endoplasmic reticulum, [Ca 2+ ] er, are depicted. Inositol triphosphate receptors (IP 3 Rs) represent the most likely ER calcium channel of relevance (1).