Next was founded in 1985 by Apple Computer co-Â­founder Steve Jobs, after he was forced out of Apple, along with a few of his co-Â­workÂ­erÂ­s. Next inÂ­troÂ­duced the first Next Computer in 1988, and the smaller NextstaÂ­tion in 1990. Apple purÂ­chased Next on December 20, 1996. As part of the agreeÂ­menÂ­t, Steve Jobs, Chairman and CEO of Next SoftÂ­ware, returned to Apple, the company he co-Â­foundÂ­ed in 1976. Companies quiz Which company built Burj Khalifa in Dubai?
Aldosterone causes vasoconstriction in coronary arterioles of rats via angiotensin II type-1 receptor: influence of hypertension. Kushibiki M, Yamada M, Oikawa K, Tomita H, Osanai T, Okumura K.[PubMed-indexed for MEDLINE].ldosterone causes vasoconstriction in coronary arterioles of rats via angiotensin II type-1 receptor: influence of hypertension. Kushibiki M, Yamada M, Oikawa K, Tomita H, Osanai T, Okumura K. [PubMed-indexed for MEDLINE].
Aldosterone is a steroid secreted by the cortex of the adrenal gland. It is. the most potent hormone regulating the body's electrolyte balance. Aldosterone acts directly on the kidney to decrease the rate of sodium-ion excretion (with accompanying retention of water), and to increase the rate of potassium-ion excretion. The secretion of aldosterone appears to be regulated by two mechanisms. First, the concentration of sodium ions may be a factor since increased rates of aldosterone secretion are found when dietary sodium is severely limited. Second, reduced blood flow to the kidney stimulates certain kidney cells to secrete the proteolytic enzyme renin, which converts the inactive angiotensinogen globulin in the blood into angiotensin I. Another enzyme then converts angiotensin I into angiotensin II, its active form. This peptide, in turn, stimulates the secretion of ...