Hyperthyroidism and Thyrotoxicosis Clinical Presentation - Physical Examination. 1  The thyroid is located in the lower anterior neck. 2  Common signs of thyrotoxicosis include the following... 3  Thyrotoxicosis from Graves disease is associated with a diffusely enlarged and slightly firm thyroid gland. Sometimes, a thyroid bruit can be heard by using the bell of the stethoscope. Toxic multinodular goiters generally occur when the thyroid gland is enlarged to at least 2 to 3 times the normal size.
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