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Severe depression. Severe depression causes symptoms of low mood, tiredness, loss of interest, despair and hopelessness that interfere with a person's life. People with severe depression are much more likely to attempt suicide than the general population.
Biological depression is thought to be triggered by changes in the body with no contribution from external events. Periods of stress or trauma â a result of events such as losing a job or a loved one â are the most commonly cited triggers for the onset of depression in individuals.