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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
The endoplasmic reticulum (ER) is a type of organelle in the cells of eukaryotic organisms that forms an interconnected network of flattened, membrane-enclosed sacs or tube like structures known as cisternae.he endoplasmic reticulum serves many general functions, including the folding of protein molecules in sacs called cisternae and the transport of synthesized proteins in vesicles to the Golgi apparatus.