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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
Endoplasmic Reticulum Structure. Endoplasmic reticulum is an extensive membrane network of cisternae (sac-like structures), which are held together by the cytoskeleton. The phospholipid membrane encloses a space, the lumen from the cytosol, which is continuous with the perinuclear space.