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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
endoplasmic reticulum. a system of folded membranes, channels, and flattened sacs in the cytoplasm of eukaryotic cells, involved in the synthesis, storage, and transport of various substances necessary to cell function: as the point of attachment for ribosomes, it is especially associated with protein synthesis.INK / CITE ADD TO WORD LIST. noun. The endoplasmic reticulum is defined as a series of folded membranes in the cells which are associated with protein synthesis, storage and the movement of cellular materials.