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Loop of Henle -- This segment of the nephron plays a major role in the countercurrent exchange/multiplier system of water conservation. It has the ability to concentrate solutes, increase osmotic pressure, and conserve or excrete water.It also serves as a sight of Na, K, and Cl conservation.oop of Henle -- This segment of the nephron plays a major role in the countercurrent exchange/multiplier system of water conservation. It has the ability to concentrate solutes, increase osmotic pressure, and conserve or excrete water. It also serves as a sight of Na, K, and Cl conservation.
Regulation of Na + Reabsorption. The principal regulator of Na + reabsorption is the steroid hormone aldosterone, which is produced in the zona glomerulosa of the adrenal cortex. Aldosterone, like all steroid hormones, works as a transcription factor to alter gene expression in cells.he figure provides an overview of Na + reabsorption along the nephron. In different segments of the renal tubule, there are different proteins (co-transporters, counter-transporters, or channels) on the apical surface of tubule cells that mediate Na + reabsorption.