Story at-a-glance 1  +. Canine leptospirosis, or âlepto,â is an infection caused by at least four species (serovars) of Leptospira bacteria. 2  However, there are over 20 different serovars that are potentially infectious to dogs.3  Leptospirosis isnât a new disease â in fact, itâs ancient.tory at-a-glance 1  +. Canine leptospirosis, or âlepto,â is an infection caused by at least four species (serovars) of Leptospira bacteria. 2  However, there are over 20 different serovars that are potentially infectious to dogs.
Philip Morris, a London-based cigarette manufacturer, created a New York subsidiary in 1902 to sell several of its cigarette brands, including Marlboro. By 1924 they were advertising Marlboro as a woman's cigarette based on the slogan Mild As May.
It mechanically formed, pasted, closed, and cut cigarettes with a rotary blade. Six years later this machine was refined by William O'Brien and James B. Duke, and it produced 4,000,000 cigarettes per day and reduced costs by 50 cents per every 1,000 made.