As outlined in Chapter 4, you begin the proposal development process. with an understanding of the need or problem as the basis for conceptual-. izing your proposed program or intervention. Likewise, when you begin. writing the proposal, the needs/problem statement is typically the first. section completed.
An example of this is Down syndrome. Down syndrome is a disease in which the chromosomes failed to separate properly during meiosis leading to three chromosomes of type 21 instead of two. A person with the condition therefore has a total of 47 chromosomes instead of 46. The non-disjunction can take place either in the formation of the egg or the sperm.
1 Trisomy 21 â More than 90% of Down syndrome cases are caused by trisomy 21. 2  An extra chromosome (chromosome 21) originates in the development of either the sperm or the egg. 3  When the egg and the sperm unite to form the fertilized egg, three (rather than two) chromosomes 21 are present.