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Severe depression. Severe depression causes symptoms of low mood, tiredness, loss of interest, despair and hopelessness that interfere with a person's life. People with severe depression are much more likely to attempt suicide than the general population.
Subscribe to our Managing Depression e-newsletter to stay up to date on depression topics. It's not known exactly what causes depression. As with many mental disorders, a variety of factors may be involved, such as: 1  Biological differences.2  People with depression appear to have physical changes in their brains. 3  The significance of these changes is still uncertain, but may eventually help pinpoint causes.4  Brain chemistry.ubscribe to our Managing Depression e-newsletter to stay up to date on depression topics. It's not known exactly what causes depression. As with many mental disorders, a variety of factors may be involved, such as: 1  Biological differences.