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Distribution of edema: Unilateral. leg edema is generally due to a local cause such as deep vein thrombosis, venous insufficiency, or lymphedema. Bilateral. edema can be due to a local cause or systemic disease, such as heart failure or kidney disease. Generalized. edema is due to systemic disease.
1. edema caused by the accumulation of fluid in the extracellular spaces of a tissue. 2. pulmonary edema in the interstitial tissues; there is dyspnea but no hypoxemia. edema neonatoÂ´rum sclerema neonatorum. nonpitting edema edema in which pressure does not leave a depression in the tissues, such as in cellular edema.itting edema edema in which external pressure leaves a persistent depression in the tissues (see pitting); it occurs because the pressure pushes the excess fluid out of the intercellular spaces in the tissue. See also nonpitting edema.