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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
The endoplasmic reticulum plays an important role in the biosynthesis, processing, and transport of â¦EncyclopÃ¦dia Britannica, Inc. Rough ER is named for its rough appearance, which is due to the ribosomes attached to its outer (cytoplasmic) surface.