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No, not necessarily, but it can cause a minor issue. iPhones use a Lithium-Ion battery for its power, using while it's charging won't necessarily ruin the battery, but if you're using the phone while the battery is in the charging process, it can cause the phone to think it has more power than it actually has.
If you have a charger that can charge the battery out of the phone, you can overcharge the battery, Chargers like that are designed for specific batteries, and you should only use them with the battery they're designed for, even if a different battery fits. Thanked by: mattatwar1. mattatwar1.