Tweet. : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease.weet. : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease.
Not only trade but also the production of goods increased as a result of new ways of organizing production. Merchants, entrepreneurs, and bankers accumulated and manipulated capital in unprecedented volume. Most historians locate in the 16th century the beginning, or at least the maturing, of Western capitalism.
England was not the most powerful European nation in the 16th century. Spain was most influential. Along with Portugal, Spain dominated New World exploration in the decades that followed Columbus.France, the Netherlands, and Sweden all showed greater interest in the Western Hemisphere than England did.ngland was not the most powerful European nation in the 16th century. Spain was most influential. Along with Portugal, Spain dominated New World exploration in the decades that followed Columbus.