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Distribution of edema: Unilateral. leg edema is generally due to a local cause such as deep vein thrombosis, venous insufficiency, or lymphedema. Bilateral. edema can be due to a local cause or systemic disease, such as heart failure or kidney disease. Generalized. edema is due to systemic disease.
generalized edema edema that is caused by poor venous return; it is not localized by the effects of gravity, in contrast to dependent edema. interstitial edema 1. edema caused by the accumulation of fluid in the extracellular spaces of a tissue.