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Distribution of edema: Unilateral. leg edema is generally due to a local cause such as deep vein thrombosis, venous insufficiency, or lymphedema. Bilateral. edema can be due to a local cause or systemic disease, such as heart failure or kidney disease. Generalized. edema is due to systemic disease.
Edema is swelling caused by fluid retention-excess fluid is trapped in the body's tissues. In the UK/Ireland/Australasia and some other countries, the word is spelled oedema. Swelling caused by edema commonly occurs in the hands, arms, ankles, legs and feet.It is usually linked to the venous or lymphatic systems. Edema is normally caused by a more significant underlying disease or condition. 2  A number of medications appear to cause pedal edema (foot edema). 3  Lucentis (ranibizumab injection) is an FDA-approved treatment for diabetic macular edema.