At usual clinical doses and dosing schedules of metformin, steady state plasma concentrations of metformin are reached within 24 to 48 hours and are generally <1 Âµg/mL. During controlled clinical trials of metformin, maximum metformin plasma levels did not exceed 5 Âµg/mL, even at maximum doses.
FBI Director Christopher Wray offered a spirited defense of his agency before Congress on Thursday, four days after President Donald Trump said its reputation was in tatters. Wray, who was appointed by Trump to succeed James Comey, appeared before the House Judiciary Committee and was clearly prepared for questions about the tweet. Asked about it, he spoke for two minutes without notes.
Sutter Health hires Wright for CTO post. Wes Wright, senior VP and CIO at Seattle Children's Hospital, has been named chief technology officer at Sutter Health, Sacramento, Calif.