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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
Endoplasmic Reticulum. The endoplasmic reticulum is a multifold membranous structure within eukaryotic cells which plays a major role in the synthesis of the complex molecules required by the cell and the organism as a whole.xamples of protein synthesis by the rough endoplasmic reticulum are the proteins produced in secretory cells. These include the digestive enzymes produced in the stomach and the protein hormones like insulin produced in the pancreas.