This model is based on the in vitro skin model Skin2 [5] which had been discontinued in October 1996. It was further proposed by industry to apply the model in a tiered strategy to identify those chemicals that are predicted to be likely to be phototoxic in the 3T3-NRU-PT but are negative in vivo [6].
401(k) contribution rules. On a pretax basis, employees can't contribute above certain limits. In 2015, for instance, the limit is $18,000; those 50 and older can make additional catch-up contributions of $6,000.This money is not counted toward income, and all gains are tax-deferred. The limits are the same for Roth 401(k)s, though the contributions do count toward income and all gains are tax-free.But employees can sock away a lot more retirement cash if their company plan offers an after-tax option in a traditional 401(k).he limits are the same for Roth 401(k)s, though the contributions do count toward income and all gains are tax-free. But employees can sock away a lot more retirement cash if their company plan offers an after-tax option in a traditional 401(k).
Matching 401K or 403b contributions made by your employer are NOT counted toward your annual 401k contribution limits (elective deferrals), $17,500 in 2014. Even if you contribute the maximum amount each year, your employerâs matching contributions are in addition to these 401k limits.or those over 50, SIMPLE IRA or SIMPLE 401(k) plans may permit catch-up contributions up to $2,500. This is above the standard $11,500 contribution limit for SIMPLE IRA plans. You can also make catch-up contributions of up to $1,000 to your Traditional or Roth IRA.