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Those of us who are deficient and start on a vitamin D supplement usually take five to six weeks to reach the recommended level of vitamin D. If you're in doubt, it's always best to have a chat with your GP who might arrange a blood test. The B vitamins and vitamin C are all water soluble.
In studying the effect of vitamin C supplements on reducing DNA damage in blood cells, Danish researchers gave relatively low doses (500 mg/day) of vitamin C as plain-release or slow-release tablets combined with vitamin E (182 mg/day), or placebo, for four weeks to a group of male smokers.