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Freebase(0.00 / 0 votes)Rate this definition: Diltiazem. Diltiazem is a nondihydropyridine member of the class of drugs known as calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. It is also an effective preventive medication for migraine. It is a class 3 antianginal drug, and a class IV antiarrhythmic.
Diltiazem is a prescription medication used for controlling high blood pressure and treating certain types of chest pain. The medication is a type of calcium channel blocker that helps to relax the blood vessels to improve blood flow.