(kÄn'sÉr) 1  A disease characterized by any of various malignant neoplasms composed of abnormal cells that tend to proliferate rapidly and invade surrounding tissue. Without treatment such as chemotherapy or radiation, cancer cells can metastasize to other body sites and cause organ failure and death. 2  A malignant tumor.
Dosage and Administration (2.6, 2.7) 8/2016. Warnings and Precautions (5.10) 8/2016. INDICATIONS AND USAGE Gleevec is a kinase inhibitor indicated for the treatment of: Newly diagnosed adult and pediatric patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase (1.1)
The BCR-ABL tyrosine kinase inhibitor (TKI) GleevecÂ® is FDA approved for adults with Ph positive CML in blast crisis phase, accelerated phase, or in chronic phase after failure of interferon alpha therapy. Other drug choices include Sprycel, Tasigna, Bosulif and Synribo. A clinical trial is another treatment choice.