This model is based on the in vitro skin model Skin2 [5] which had been discontinued in October 1996. It was further proposed by industry to apply the model in a tiered strategy to identify those chemicals that are predicted to be likely to be phototoxic in the 3T3-NRU-PT but are negative in vivo [6].
401(k) contribution rules. On a pretax basis, employees can't contribute above certain limits. In 2015, for instance, the limit is $18,000; those 50 and older can make additional catch-up contributions of $6,000.This money is not counted toward income, and all gains are tax-deferred. The limits are the same for Roth 401(k)s, though the contributions do count toward income and all gains are tax-free.But employees can sock away a lot more retirement cash if their company plan offers an after-tax option in a traditional 401(k).he limits are the same for Roth 401(k)s, though the contributions do count toward income and all gains are tax-free. But employees can sock away a lot more retirement cash if their company plan offers an after-tax option in a traditional 401(k).
Much like the Roth IRA, the Roth 401(k) is funded upfront with after-tax dollars. Once you hit age 59.5 you are able to start withdrawing from the account tax-free. The edge the Roth 401(k) has over its IRA cousin is that the 401(k) contribution limits still apply to the 401(k) version.Meaning that you can contribute a full $17,000 per year to the Roth 401(k) while you are limited to just $5000 in the Roth IRA.So the Roth 401(k) is great just like the Roth IRA except that weâre able to contribute A LOT more money to it each year.f you decide to contribute to a Roth instead of a your Traditional 401(k) you can expect your tax bill to go up in April because youâll be contributing after tax dollars instead of pre-tax as you had been. If you have a Roth 401(k) available to you definitely take the time to consider your options.