RAS/MAPK signaling helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (migration), and the self-destruction of cells (apoptosis). The RAF1 gene belongs to a class of genes known as oncogenes.
Raigad Fort has a historical significance in India and Maharashtra. Also known as capital of Swarajya(Freedom), this fort was the capital of Chhatrapati Shivaji Maharaj, one of the great heros of India. Shivaji Maharaj,Founder and King of the Maratha Empire, fought against various rulers to defend freedom in the 17th Century. He chose rairi fort as his capital and renamed it to Raigad.
Sindhu (Hindi: à¤¸à¤¿à¤¨à¥à¤§à¥, Urdu: Ø³ÙØ¯Ú¾Ù) was a kingdom of India mentioned in the epic Mahabharata and in the Harivamsa Purana. It stretched along the banks of river Sindhu (Indus) in the ancient era in modern Pakistan. It is believed that Sindhu kingdom was founded by Vrsadarbh, one of sons of Sivi.he river Sindhu (Indus) too is flowing with a current of fresh blood.. (3:223) The seven large rivers including the Sindhu (Indus) though flowing eastwards then flowed in opposite directions. The very directions seemed to be reversed and nothing could be distinguished.