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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
The endoplasmic reticulum is composed of sac-like structures called cisternae that are folded and bound together by a cytoskeleton. There are two types of endoplasmic reticulum: smooth endoplasmic reticulum and rough endoplasmic reticulum.Smooth endoplasmic reticulum gets its name from its smooth folded surface.efinition of Endoplasmic Reticulum. Cells have many organelles that work together to help them complete their life functions. One of those organelles is the endoplasmic reticulum, which is an interconnected network of membrane vesicles, or small containers used by cells to transport or hold materials.