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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
Organelles are specialized membrane-enclosed structures in the cytoplasm of eukaryotic cells. The nucleus, which contains DNA in the form of chromosomes, is the most characteristic eukaryotic organelle. The nuclear envelope is connected to a system of membranes in the; cytoplasm called the endoplasmic reticulum (ER).