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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
Endoplasmic Reticulum. Endoplasmic reticulum is a continuous membrane, which is present in both plant cells, animal cells and absent in prokaryotic cells. It is the membrane of network tubules and flattened sacs, which serves a variety of functions within the cell.ndoplasmic Reticulum. Endoplasmic reticulum is a continuous membrane, which is present in both plant cells, animal cells and absent in prokaryotic cells. It is the membrane of network tubules and flattened sacs, which serves a variety of functions within the cell.