As outlined in Chapter 4, you begin the proposal development process. with an understanding of the need or problem as the basis for conceptual-. izing your proposed program or intervention. Likewise, when you begin. writing the proposal, the needs/problem statement is typically the first. section completed.
An example of this is Down syndrome. Down syndrome is a disease in which the chromosomes failed to separate properly during meiosis leading to three chromosomes of type 21 instead of two. A person with the condition therefore has a total of 47 chromosomes instead of 46. The non-disjunction can take place either in the formation of the egg or the sperm.
Typically, a baby has 46 chromosomes. Babies with Down syndrome have an extra copy of one of these chromosomes, chromosome 21. This extra copy changes the bodyâs and brainâs development and can cause mental and physical problems for the baby.ome examples of physical problems associated with Down syndrome include a birth defect of the heart or problems with the stomach, hearing, skeleton, intestines, thyroid, or eyes. People with Down syndrome usually have an IQ in the mild-to-moderate range of intellectual disabilities.