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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
The nucleus communicates to the cell cytoplasm through the nuclear pores present in the nuclear membrane. The nuclear membrane is continuous with the endoplasmic reticulum. The DNA is responsible for cell division, growth and protein synthesis.