As outlined in Chapter 4, you begin the proposal development process. with an understanding of the need or problem as the basis for conceptual-. izing your proposed program or intervention. Likewise, when you begin. writing the proposal, the needs/problem statement is typically the first. section completed.
An example of this is Down syndrome. Down syndrome is a disease in which the chromosomes failed to separate properly during meiosis leading to three chromosomes of type 21 instead of two. A person with the condition therefore has a total of 47 chromosomes instead of 46. The non-disjunction can take place either in the formation of the egg or the sperm.
Who Discovered Down Syndrome. Down syndrome is a chromosomal disorder that produces a set of mental and physical symptoms. It is caused by an extra copy of chromosome 21. In a person with Down syndrome there are three copies of the chromosome 21, one from the father, one from the mother and a third copy.The extra copy of this chromosome changes the development of the brain and body.Down syndrome affects about 1 in every 800 babies.r Down could not identify what caused the condition and it was not until 1959 that a Professor named Jerome JÃ©rome lejeune discovered That down syndrome was caused by a chromosomal. Irregularity he found that in people With down syndrome an extra chromosome was. present