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At onset of muscle contraction, myoglobin (Mb) immediately releases its bound O 2 to the mitochondria. Accordingly, intracellular O 2 tension (P mb O 2) markedly declines in order to increase muscle O 2 uptake (m O 2).t onset of muscle contraction, myoglobin (Mb) immediately releases its bound O 2 to the mitochondria. Accordingly, intracellular O 2 tension (P mb O 2) markedly declines in order to increase muscle O 2 uptake (m O 2).
BSI Activity Page 4. During contraction, myosin heads in the thick filaments (which stick out towards the thin. filaments) bind actin in the thin filaments and pull the thin filaments in towards the center. There. are many sites at which myosin binds actin, running the entire length of the thin filament/thick.