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Freebase(0.00 / 0 votes)Rate this definition: Diltiazem. Diltiazem is a nondihydropyridine member of the class of drugs known as calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. It is also an effective preventive medication for migraine. It is a class 3 antianginal drug, and a class IV antiarrhythmic.
A: Generalized body aches are not listed as a side effect of diltiazem in the package insert. Muscle cramps, however, are listed as a possible side effect. Derek Dore, PharmD. A: Diltiazem is a calcium channel blocker used to treat high blood pressure and angina. It should be taken with a full glass of water, either with or without food. Some reports indicate that grapefruit or grapefruit juice may interfere with the absorption of diltiazem.