At usual clinical doses and dosing schedules of metformin, steady state plasma concentrations of metformin are reached within 24 to 48 hours and are generally <1 Âµg/mL. During controlled clinical trials of metformin, maximum metformin plasma levels did not exceed 5 Âµg/mL, even at maximum doses.
FBI Director Christopher Wray offered a spirited defense of his agency before Congress on Thursday, four days after President Donald Trump said its reputation was in tatters. Wray, who was appointed by Trump to succeed James Comey, appeared before the House Judiciary Committee and was clearly prepared for questions about the tweet. Asked about it, he spoke for two minutes without notes.
James Brien Jim Comey, Jr. (born December 14, 1960) is an American lawyer and the current Director of the Federal Bureau of Investigation (FBI). Comey was the United States Deputy Attorney General from December 2003 to August 2005, serving in President George W. Bush's administration. As Deputy Attorney General, Comey was the second-highest-ranking official in the United States Department of Justice (DOJ), and ran the day-to-day operations of the Department.