RAS/MAPK signaling helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (migration), and the self-destruction of cells (apoptosis). The RAF1 gene belongs to a class of genes known as oncogenes.
Raigad Fort has a historical significance in India and Maharashtra. Also known as capital of Swarajya(Freedom), this fort was the capital of Chhatrapati Shivaji Maharaj, one of the great heros of India. Shivaji Maharaj,Founder and King of the Maratha Empire, fought against various rulers to defend freedom in the 17th Century. He chose rairi fort as his capital and renamed it to Raigad.
Qutb-ud-din Aibak, a former slave of Muhammad Ghori, was the first sultan of Delhi and his dynasty conquered large areas of northern India. Afterwards the Khilji dynasty was also able to conquer most of central India, but both failed to unite the Indian subcontinent.ltutmish's rule lasted till 1236. Following his death, the Delhi Sultanate saw a succession of weak rulers, disputing Muslim nobility, assassinations, and short-lived tenures. Power shifted from Rukn ud din Firuz to Razia Sultana and others, until Ghiyas ud din Balban came to power and ruled from 1266 to 1287.