The recommended dosing with donepezil starts at 5 mg once a day but may be increased after several weeks -- this gradual change decreases the risk of side effects. Donepezil comes in the form of oral tablets and orally disintegrating tablets. Your dosage should be taken every day at bedtime, with or without food.
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Melatonin supplements are a relatively safe substance when used in the short term: over a period of days or weeks. Furthermore, melatonin has been shown to be safe at relatively high doses and in various formulations.However, the safety of melatonin when used over months and years, remains unclear.hanks for your question. In its natural form, melatonin is produced by the brainâs pineal gland to regulate the sleep cycle. When the body is working best, the level melatonin in the bloodstream rises sharply, reducing alertness and inviting sleep, and in the morning it falls back, encouraging waking.