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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
The endoplasm is the inner core of the cytoplasm and the membranes of the ER are continuous with the outer membrane of the nuclear envelope. Endoplasmic reticulum occurs in most types of eukaryotic cells, including the most primitive Giardia, but is absent from red blood cells and spermatozoa.he endoplasm is the inner core of the cytoplasm and the membranes of the ER are continuous with the outer membrane of the nuclear envelope. Endoplasmic reticulum occurs in most types of eukaryotic cells, including the most primitive Giardia, but is absent from red blood cells and spermatozoa.