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The nucleus works with the endoplasmic reticulum because the  nucleus controls all the organelles and functions of the cell. This  means the nucleus controls what the er doe â¦ s. Answered. In Cell Biology (cytology).
Endoplasmic reticulum is a system of tubules. If there are ribosomes on the tubules, it is termed rough endoplasmic reticulum. Ribosomes produce proteins. When the ribosomes are attached to endoplasmic reticulum, the proteins produced by the ribosomes are exported.