As outlined in Chapter 4, you begin the proposal development process. with an understanding of the need or problem as the basis for conceptual-. izing your proposed program or intervention. Likewise, when you begin. writing the proposal, the needs/problem statement is typically the first. section completed.
An example of this is Down syndrome. Down syndrome is a disease in which the chromosomes failed to separate properly during meiosis leading to three chromosomes of type 21 instead of two. A person with the condition therefore has a total of 47 chromosomes instead of 46. The non-disjunction can take place either in the formation of the egg or the sperm.
Down Syndrome is correlated with age of mother but can also be the result of nondisjunction of the father's chromosome 21. Karyotype of a boy with Down Syndrome: B. Patau syndrome (trisomy 13): serious eye, brain, circulatory defects as well as cleft palate. 1:5000 live births. Children rarely live more than a few months.