Tweet. : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease.weet. : a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease.
Not only trade but also the production of goods increased as a result of new ways of organizing production. Merchants, entrepreneurs, and bankers accumulated and manipulated capital in unprecedented volume. Most historians locate in the 16th century the beginning, or at least the maturing, of Western capitalism.
Widespread credit, business corporations, investments and large-scale stock markets all become common. Britain led the way in this transformation. By the 1780s, the British Industrial Revolution, which had been developing for several decades, began to further accelerate. Manufacturing, business, and the number of wage laborers skyrocketed, starting a trend that would continue into the first half of the 19th century.