Depot injection. A depot injection is an injection, usually subcutaneous, intradermal, or intramuscular, that deposits a drug in a localized mass, called a depot, from which it is gradually absorbed by surrounding tissue. Such injection allows the active compound to be released in a consistent way over a long period.
The Vanquish TM is a tunable, focused bipolar radiofrequency device which is FDA-approved for deep tissue heating. The deep tissue heating preferentially focuses in on the fat layer, and causes it to shrink by causing most of the fat cells to die off.
It was initially approved by the FDA in 2012 for patients with metastatic HER2-positive breast cancer, and pertuzumab is the first drug approved by the FDA for the neoadjuvant treatment of breast cancer. The FDA also largely based the accelerated approval on data from the NeoSphere study.