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When the body is making and using ketones we say that the body is in a state of ketosis. Ketosis begins after about 48 hours (2 days) or water fast for women, or about 72 hours (3 days) of water fast for men.hen the body is making and using ketones we say that the body is in a state of ketosis. Ketosis begins after about 48 hours (2 days) or water fast for women, or about 72 hours (3 days) of water fast for men.
Most are over by the first week of a ketogenic diet, though some may extend to two weeks. Athletes who closely track their performance may notice more subtle effects up to 6-8 weeks from the start of the diet, and there is some evidence that it may take even longer, up to 12 weeks, for 100% adaptation.