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Distribution of edema: Unilateral. leg edema is generally due to a local cause such as deep vein thrombosis, venous insufficiency, or lymphedema. Bilateral. edema can be due to a local cause or systemic disease, such as heart failure or kidney disease. Generalized. edema is due to systemic disease.
Edema is swelling of soft tissues due to increased interstitial fluid. The fluid is predominantly water, but protein and cell-rich fluid can accumulate if there is infection or lymphatic obstruction. Edema may be generalized or local (eg, limited to a single extremity or part of an extremity). It sometimes appears abruptly; patients complain that an extremity suddenly swells.