If ACTH independent, it is due to the autonomous function of one or both adrenal glands, including adrenal adenomas, adrenocortical carcinomas, and micronodular or macronodular hyperplasia. The clinical manifestations of Cushing's syndrome are protean and reflect the catabolic actions of cortisol on skin, muscle, bone, liver, and fat.
The words effacement, being effaced and effacing are terms that you will hear often as you approach your last trimester. These terms are used to describe the process that the cervix prepares itself for delivery and it is measured by percentage.
Feeling unusually fatigued is an early pregnancy symptom that can occur as soon as one week after you conceive. The excessive tiredness is often related to a high level of progesterone in your system, although other things such as lower levels of blood sugar, lower blood pressure, and increased blood production can all contribute.