If ACTH independent, it is due to the autonomous function of one or both adrenal glands, including adrenal adenomas, adrenocortical carcinomas, and micronodular or macronodular hyperplasia. The clinical manifestations of Cushing's syndrome are protean and reflect the catabolic actions of cortisol on skin, muscle, bone, liver, and fat.
Prior to pregnancy and into much of the third trimester your cervix is long and thick. As labor nears it begins to shorten and thin out. This action is referred to as effacement. Effacement is generally measured in percentages by doctors and midwives.
Miscarriage Overview. A miscarriage (also termed spontaneous abortion) is any pregnancy that spontaneously ends before the fetus can survive. Any vaginal bleeding, other than spotting, during early pregnancy is considered a threatened miscarriage. Vaginal bleeding is very common in early pregnancy.About one out of every four pregnant women has some bleeding during the first few months. About half of these women stop bleeding and complete a normal pregnancy. 1  Threatened miscarriage-Vaginal bleeding during early pregnancy.2  The bleeding and pain with threatened miscarriage are usually mild and the cervical os (the mouth of the womb) is closed.iscarriage is caused by the separation of the fetus and placenta from the uterine wall. Although the actual cause of the miscarriage is frequently unclear, the most common reasons include the following: 1  An abnormal fetus causes almost all miscarriages during the first three months of pregnancy (first trimester).