NSAIDs interact with the endocannabinoid system and its endocannabinoids, as COX2 have been shown to utilize endocannabinoids as substrates, and may have a key role in both the therapeutic and adverse effects of NSAIDs, as well as in NSAIDs-induced placebo responses.
Definition: An independent variable is the variable that is changed or controlled in a scientific experiment. Independent variables are the variables that the experimenter changes to test their dependent variable.
2. Free from the influence, guidance, or control of another or others; self-reliant: an independent mind. 3. Not determined or influenced by someone or something else; not contingent: a decision independent of the outcome of the study.