1 Spread of the cancer to other parts of the body: Pain caused by cancer itself is more common in people who have metastatic (or advanced) disease, in which the breast cancer spreads to other parts of the body.
Toxicological Effects: 1  Acute toxicity: Atrazine is slightly to moderately toxic to humans and other animals. 2  Chronic toxicity: Some 40% of rats receiving oral doses of 20 mg/kg/day for 6 months died with signs of respiratory distress and paralysis of the limbs.
Nearly all Arimidex side effects are resultant of its effect on the body in reduction of total circulating Estrogen levels as a result of the inhibition of the aromatase enzyme. The following are all of the major potential Arimidex side effects associated with Estrogen reduction.