Back to TopCauses. Injury or surgery involving the leg, ankle, or foot can cause swelling. Swelling may also occur after pelvic surgery, especially for cancer. Long airplane flights or car rides, as well as standing for long periods of time, often lead to some swelling in the feet and ankles.
Medical Definition of Serotonin. Serotonin: A neurotransmitter that is involved in the transmission of nerve impulses. Serotonin can trigger the release of substances in the blood vessels of the brain that in turn cause the pain of migraine. Serotonin is also key to mood regulation; pain perception; gastrointestinal function, including perception of hunger and satiety; and other physical functions.
Serotonin syndrome is an increasingly common adverse drug reaction, which can be life-threatening. Despite the common use of medications with direct or indirect serotonergic effects, many physicians are not aware of the presentation and management of serotonin excess.