1 4/2 and 4/8 are also simple quadruple. 2  Notice that a time signature in simple meter will always have a 2, 3, or 4 for the top number. 3  While beats in simple meter are divided into two notes, beats in compound meter are divided into three. 4  To demonstrate this, we will examine 6/8 time.
The Discovery and Isolation of Caffeine. Caffeine has been used as a medicinal and recreational drug since before recorded history, by consumption of caffeine bearing plants. However, the discovery of the chemical did not occur until a young physician called Friedlieb Ferdinand Runge isolated and purified the white crystalline substance in 1819.
V. cholerae was first isolated as the cause of cholera by Italian anatomist Filippo Pacini in 1854, but his discovery was not widely known until Robert Koch, working independently 30 years later, publicized the knowledge and the means of fighting the disease.