That's a little more than the typical 125 milligrams found in a cup of coffee. About 13 percent of the men reported leaky bladder, but only 4.5 percent had a problem considered moderate or severe - which is more than a few drops of urine leakage during the course of a month.
Irritability can be the result of a wide variety of other conditions, diseases or disorders that directly or indirectly affect the functioning of the brain and nervous system. These include intellectual decline, hypoxia and chronic pain. For more details about causes, see causes of irritability.
The exact cause of irritable bowel syndrome is unknown. It is called a syndrome because it causes a wide range of symptoms that range from gas, bloating, and pain to constipation and diarrhea. Excessive stress, (either emotional or physical) can trigger flare-ups as can the wrong foods, hormonal variations, and even changes in activity patterns.