NSAIDs interact with the endocannabinoid system and its endocannabinoids, as COX2 have been shown to utilize endocannabinoids as substrates, and may have a key role in both the therapeutic and adverse effects of NSAIDs, as well as in NSAIDs-induced placebo responses.
Definition: An independent variable is the variable that is changed or controlled in a scientific experiment. Independent variables are the variables that the experimenter changes to test their dependent variable.
Definition of empirical. 1  1 : originating in or based on observation or experience empirical data. 2  2 : relying on experience or observation alone often without due regard for system and theory an empirical basis for the theory. 3  3 : capable of being verified or disproved by observation or experiment empirical laws.  4 : of or relating to empiricism.