A cardinal feature of sarcoidosis is the presence of CD4+ T cells that interact with antigen-presenting cells to initiate the formation and maintenance of granulomas (Figure 2 Figure 2 Hypothesized Immunopathogenesis of Sarcoidosis.
Offset may refer to: 1  Offset (film), a 2006 film featuring RÄzvan Vasilescu and Alexandra Maria Lara. 2  Offset (law), a reduction in the amount to be paid by a losing party on the basis of debt owed by the prevailing party. 3  Offset agreement, a trade practice in the aerospace and defense industry.
Negative offset is the when the mounting surface is closer to the center of the car compared to the wheel centerline. Positive offset is the opposite, and refers to when the mounting surface of the wheel is farther away from the car than the wheel's centerline. Zero offset refers to a wheel that is neither positive or negative offset. The mounting surface is centered in the wheel.