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What are Mast Cells? Mast cells (MC) are immune system cells that live in the bone marrow and in body tissues, internal and external, such as the gastrointestinal tract, the lining of the airway, and the skin. Everyone has mast cells in their body, and they play many complex and critical roles in keeping us healthy.
Symptoms of Mast Cell Tumors. A mast cell tumor usually shows up as an isolated lump or mass, although they can appear in clusters or in multiple areas of the skin. Most affected dogs show no symptoms of irritation or illness. Owners of dogs with mast cell tumors may notice one or more of the following: 1  Lumps or bumps on or under the skin of the torso (trunk), underbelly (abdominal area) and hind legs, and around the anus and genital area. 2  Lumps or bumps anywhere on or under the skin.