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The driving distance between Knoxville, TN and Birmingham, AL is approximately 255 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non- â¦ stop in good driving conditions.
Nestled in southern Auglaize County, New Knoxville is located at the intersection of State Routes 29 & 219, and is just minutes from Interstate 75. These highways allow one to travel to/from Chicago, Illinois; Frankfort, Kentucky; Charleston, West Virginia; or Erie, Pennsylvania in less than 5 hours.