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However, too much magnesium from nonfood sources, such as magnesium salts, has been shown to cause mild to severe toxicity. Symptoms can range from diarrhea, nausea and abdominal cramps to difficulty breathing, extremely low blood pressure and irregular heartbeat.
But PPI use can change the way your kidneys remove extra magnesium from your body, causing you to lose too much. Magnesium depletion is more common when you use both a PPI and a diuretic (a medication to remove extra water from your body).