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Bilirubin (formerly referred to as haematoidin) is the yellow breakdown product of normal heme catabolism, caused by the body's clearance of aged red blood cells which contain hemoglobin.Bilirubin is excreted in bile and urine, and elevated levels may indicate certain diseases.ilirubin consists of an open chain of four pyrrole-like rings (tetrapyrrole). In heme, these four rings are connected into a larger ring, called a porphyrin ring. Bilirubin can be conjugated with a molecule of glucuronic acid which makes it soluble in water (see below).
conjugated bilirubin, direct bilirubin bilirubin that has been taken up by the liver cells and conjugated to form the water-soluble bilirubin diglucuronide. indirect bilirubin, unconjugated bilirubin the lipid-soluble form of bilirubin that circulates in loose association with the plasma proteins.ilirubin. A pigment produced by the liver that is excreted in bile which causes a yellow discoloration of the skin and eyes when it accumulates in those organs. Bilirubin levels can be measured by blood tests, and are most often elevated in patients with liver disease or a blockage to bile flow.