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Normal and diseased prions. Creutzfeldt-Jakob disease and its variants belong to a broad group of human and animal diseases known as transmissible spongiform encephalopathies (TSEs). The name derives from the spongy holes, visible under a microscope, that develop in affected brain tissue.The cause of Creutzfeldt-Jakob disease and other TSEs appears to be abnormal versions of a kind of protein called a prion.ormal and diseased prions. Creutzfeldt-Jakob disease and its variants belong to a broad group of human and animal diseases known as transmissible spongiform encephalopathies (TSEs). The name derives from the spongy holes, visible under a microscope, that develop in affected brain tissue.
Primary Cause of Prion diseases. The primary cause of Prion diseases is the result: 1  of transmission from another person under rare circumstances, such as immunocompromised people or during surgery with contaminated surgical tools, or according to rare circumstances as noted from reputable sources.o research the causes of Prion diseases, consider researching the causes of these these diseases that may be similar, or associated with Prion diseases: 1  Spongioform encephalopathies. 2  Creutzfeldt Jakob disease. 3  Variant Creutzfeldt-Jakob disease. 4  Gerstmann Straussler Scheinker syndrome. 5  Fatal familial insomnia. 6  Kuru.