Larry Kehres is just barely the answer to this question and now has a .925 winning percentage (before 2010 season). If he were to lose two games in 2010, he would slip back behind the coach who held the record for half a century, Milburn Catfish Smith, who had a .924 winning percentage.
Platelets are small blood cells that help stop bleeding after injury to a blood vessel by forming a clot, or plug, in the vessel. Some medications impair platelet function, leading to increased bruising and bleeding. SSRIs decrease an important platelet component called serotonin, which may cause bleeding in some patients. SSRIs include fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), fluvoxamine (Luvox) and citalopram (Celexa).
I took sertraline from 2011 for GAD, Panic Disorder, Social Anxiety, and depression caused by anxiety, and eventually weaned off in August of 2015. These past 4 months have been miserable, so I just started back up on it 2 days ago. The first time I was on it, it worked great, it just took some time to get used to.