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Eisenmenger syndrome, a type of congenital heart disease, causes pulmonary hypertension. It's most commonly caused by a large hole in your heart between the two lower heart chambers (ventricles), called a ventricular septal defect. This hole in your heart causes blood to circulate abnormally in your heart.
Development of COPD with Pulmonary Hypertension. Pulmonary hypertension is often a result of COPD and is associated with increased risks of exacerbation and decreased survival, according to the study, â Pulmonary hypertension in COPD, â published in 2008.