Definition and Etiology. Ascites is defined as the accumulation of fluid in the peritoneal cavity. It is a common clinical finding, with various extraperitoneal and peritoneal causes (Box 1), but it most often results from liver cirrhosis.
Tests for the detection of Bence-Jones Protein. Bradshaw Test. The urine specimen is treated with 1 or 2 drops of 33 per cent acetic acid to bring the pH down to 4.8 to 5.0, centrifuged clear, and diluted 1:1 with water. The diluted urine is layered carefully over concentrated HCl in a test tube.
Bence-Jones proteins are the light chain part of these monoclonal antibodies. They show up in the urine in many of cases of multiple myeloma. Myeloma cells also produce chemical signals that tell osteoclasts, or cells that break down bone, to work overtime.