If ACTH independent, it is due to the autonomous function of one or both adrenal glands, including adrenal adenomas, adrenocortical carcinomas, and micronodular or macronodular hyperplasia. The clinical manifestations of Cushing's syndrome are protean and reflect the catabolic actions of cortisol on skin, muscle, bone, liver, and fat.
Prior to pregnancy and into much of the third trimester your cervix is long and thick. As labor nears it begins to shorten and thin out. This action is referred to as effacement. Effacement is generally measured in percentages by doctors and midwives.
Bleeding in the first trimester of pregnancy is quite common and may be due to the following: 1  miscarriage (pregnancy loss). 2  ectopic pregnancy (pregnancy in the fallopian tube). 3  gestational trophoblastic disease (a rare condition that may be cancerous in which a grape-like mass of fetal and placental tissues develops).