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In domestic dogs, sexual maturity (puberty) occurs between the ages of 6 to 12 months for both males and females, although this can be delayed until up to two years of age for some large breeds. Pregnancy is possible as soon as the first estrus cycle, but breeding is not recommended prior to the second cycle.
She will come into heat anywhere from 6-9 months usually and sometime they will skip their first heat. A ***** can have her first season anytime from 6 months to 2 years, it varies widely between dogs and there's no set rule for certain breeds! From 6 months of age, same as any breed. Larger dogs go into heat a little later than smaller dogs, but it could easily be before 7 months of age. This is why you need to spay before months of age. Don't breed - the fact that you asked this questions demonstrates you shouldn't be. Spay before the first heat to protect your dog from mammary cancer.