1920 - Ashland Start. The Boston Marathon began in Ashland, Massachusetts from 1897 through 1923 then moved to Hopkinton for the 1924 race. The course was lengthened to 26 miles, 385 yards to conform to the Olympic standard, and the starting line was moved west from Ashland to Hopkinton.Since then, the race has started in Hopkinton every year.he course was lengthened to 26 miles, 385 yards to conform to the Olympic standard, and the starting line was moved west from Ashland to Hopkinton. Since then, the race has started in Hopkinton every year.
substrate-the substance that is acted upon by an enzyme or ferment. substance-the real physical matter of which a person or thing consists; DNA is the substance of our genes.
In biochemistry, the substrate is a molecule upon which an enzyme acts. Enzymes catalyze chemical reactions involving the substrate(s). In the case of a single substrate, the substrate bonds with the enzyme active site, and an enzyme-substrate complex is formed.The substrate is transformed into one or more products, which are then released from the active site. The active site is then free to accept another substrate molecule.nother example is the chemical decomposition of hydrogen peroxide carried out by the enzyme catalase. As enzymes are catalysts, they are not changed by the reactions they carry out. The substrate(s), however, is/are converted to product(s).