Larry Kehres is just barely the answer to this question and now has a .925 winning percentage (before 2010 season). If he were to lose two games in 2010, he would slip back behind the coach who held the record for half a century, Milburn Catfish Smith, who had a .924 winning percentage.
Platelets are small blood cells that help stop bleeding after injury to a blood vessel by forming a clot, or plug, in the vessel. Some medications impair platelet function, leading to increased bruising and bleeding. SSRIs decrease an important platelet component called serotonin, which may cause bleeding in some patients. SSRIs include fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), fluvoxamine (Luvox) and citalopram (Celexa).
Sertraline is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Sertraline affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms.ess serious side effects may include: 1  drowsiness, dizziness, tired feeling; 2  mild nausea, stomach pain, upset stomach, constipation; 3  dry mouth; 4  changes in appetite or weight; 5  sleep problems (insomnia); or.