a brand of plastic blocks that can be locked together, used as a childrenâs building toy. one of these blocks, usually as part of a set.
What is the heart problem that can develop while prescribed Methadone? Asked 30 Jan 2011 by ElizaJane23 Active 20 Aug 2012 Topics heart failure, heart attack, heart disease, opiate withdrawal, pain, methadone, side effect, chronic Details: I've been on Methadone 90 mg for 3-4 months now for chronic pain, and I've heard that a particular interval can be lengthened? in the heart due to this medication.
On the one hand, methadone is an opiate itself, binding to and activating mu-opioid receptors in the brain. It's this action which makes methadone a an opiate substitute that reduces cravings for harder opiates with more abuse potential, like heroin, morphine or fentanyl. Methadone does block the euphoric or mood-elevating effects of harder opiates. In other words, methadone activates mu-opioid receptors (just like morphine or heroin), but in a manner that doesn't elicit euphoria.