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In the present study, we sought to determine how the heart rate of D. magna was. affected by two previously untested compounds: curcumin and diphenhydramine (DPHM). DPHM produces a number of cardiotoxic side effects in vertebrates, particularly sinus. tachycardia. Curcumin acts as a monoamine oxidase inhibitor (MAOI) and was expected to. increase the heart rate of D. magna. DPHM was found unexpectedly to lower the heart rate of D. magna with time. Curcumin increased heart rate when administered in higher concentrations.