NSAIDs interact with the endocannabinoid system and its endocannabinoids, as COX2 have been shown to utilize endocannabinoids as substrates, and may have a key role in both the therapeutic and adverse effects of NSAIDs, as well as in NSAIDs-induced placebo responses.
Definition: An independent variable is the variable that is changed or controlled in a scientific experiment. Independent variables are the variables that the experimenter changes to test their dependent variable.
<a href=https://explorable.com/definition-of-science>Definition of Science</a>. The definition of science is the observation, identification, description, experimental investigation, and theoretical explanation of phenomena. It is in particular used in activities applied to an object of inquiry or study. [Ref]