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Causes of Iliotibial Band Syndrome. Causes of Iliotibial Band Syndrome. Iliotibial band syndrome is caused by irritation to the band of fibrous tissue that runs from the hip joint to the shinbone just below the knee joint. Risk factors include extensive running, a bowlegged stance, overpronation and leg length discrepancies.
1 The iliotibial band is a piece of tough tissue that runs from your hip down to the outer part of your knee. 2  If it's irritated by overuse or other problems, it can become inflamed and cause pain on the outer side of the knee.