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Here's how to enlarge your veins and arteries for plasma donation: 1  Heat up your arm. When veins become overheated, they expand, and draw closer to the skin. 2  Hold off on drinking and smoking. Both smoking and drinking alcoholic beverages makes veins and arteries smaller and harder. 3  Hold off on the caffeine.
Layers of Blood Vessel Walls. Like a busy highway, your blood vessels have to be well-constructed to withstand all the pressure that comes with circulating your blood every minute of every day. To help stand up to the high demand, the walls of the blood vessels are constructed of three layers known as tunics. Tunica Intima The tunica intima is the innermost layer of the arteries and veins.