Larry Kehres is just barely the answer to this question and now has a .925 winning percentage (before 2010 season). If he were to lose two games in 2010, he would slip back behind the coach who held the record for half a century, Milburn Catfish Smith, who had a .924 winning percentage.
Platelets are small blood cells that help stop bleeding after injury to a blood vessel by forming a clot, or plug, in the vessel. Some medications impair platelet function, leading to increased bruising and bleeding. SSRIs decrease an important platelet component called serotonin, which may cause bleeding in some patients. SSRIs include fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), fluvoxamine (Luvox) and citalopram (Celexa).
These changes in skin quality along with exposure to the sun can cause small blood vessels in the skin to break and bleed into the skin. Additionally, bumping or pulling on the skin can cause bruising and unexpected bleeding. If you take aspirin, it increases the likelihood of subcutaneous or under-the-skin bleeding.