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Causes of Iliotibial Band Syndrome. Causes of Iliotibial Band Syndrome. Iliotibial band syndrome is caused by irritation to the band of fibrous tissue that runs from the hip joint to the shinbone just below the knee joint. Risk factors include extensive running, a bowlegged stance, overpronation and leg length discrepancies.
Other common signs of iliotibial band syndrome: 1  Pain, tenderness, swelling, warmth or redness over the iliotibial band at the outer knee (above the joint) that may travel up or down the thigh or leg. 2  Initially, pain at the beginning of an exercise that lessens once warmed up.