1 Spread of the cancer to other parts of the body: Pain caused by cancer itself is more common in people who have metastatic (or advanced) disease, in which the breast cancer spreads to other parts of the body.
Toxicological Effects: 1  Acute toxicity: Atrazine is slightly to moderately toxic to humans and other animals. 2  Chronic toxicity: Some 40% of rats receiving oral doses of 20 mg/kg/day for 6 months died with signs of respiratory distress and paralysis of the limbs.
Other drugs related to hydroxyzine are cyclizine, buclizine, and meclizine, and they share all or most of the benefits, indications, contraindications, cautions, and side effects of hydroxyzine. The second-generation antihistamine cetirizine is in fact one of the metabolites of hydroxyzine produced in the human body. Unlike hydroxyzine, cetirizine is not reported to appreciably cross the blood-brain barrier, but it has been reported to be associated with dystonic reactions as well as sedation.