1 Spread of the cancer to other parts of the body: Pain caused by cancer itself is more common in people who have metastatic (or advanced) disease, in which the breast cancer spreads to other parts of the body.
Toxicological Effects: 1  Acute toxicity: Atrazine is slightly to moderately toxic to humans and other animals. 2  Chronic toxicity: Some 40% of rats receiving oral doses of 20 mg/kg/day for 6 months died with signs of respiratory distress and paralysis of the limbs.
Common adverse effects associated with the use of codeine include drowsiness and constipation. Less common are itching, nausea, vomiting, dry mouth, miosis, orthostatic hypotension, urinary retention, euphoria, dysphoria, and coughing.odeine is the second-most predominant alkaloid in opium, at up to three percent. Although codeine can be extracted from natural sources, a semi-synthetic process is the primary source of codeine for pharmaceutical use.