NSAIDs interact with the endocannabinoid system and its endocannabinoids, as COX2 have been shown to utilize endocannabinoids as substrates, and may have a key role in both the therapeutic and adverse effects of NSAIDs, as well as in NSAIDs-induced placebo responses.
Definition: An independent variable is the variable that is changed or controlled in a scientific experiment. Independent variables are the variables that the experimenter changes to test their dependent variable.
The independent variable is the one that is changed by the scientist. In an experiment there is only one independent. variable. As the scientist changes the independent variable, he or she observes what happens. The dependent variable changes in response to the change the scientist makes to the independent variable. The new value of. the dependent variable is caused by and depends on the value of the independent variable.