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The average age of American women having their first child reached a record high of 26 years old in 2013, according to the Centers for Disease Control and Prevention's National Vital Statistics Report.
Thus, a woman's fertility begins to decline significantly after the age of 35. Spontaneous and successful pregnancies after the age of 40 become less common, and after the age of 45 are rare (but not zero!). The woman seeking natural conception at this age will find that the facts are fairly discouraging. While 80% of women between 40 and 45 can potentially conceive with different methods, this percentage falls off dramatically after the age of 45. The average woman notices that by this time her cycle is already less regular.