NSAIDs interact with the endocannabinoid system and its endocannabinoids, as COX2 have been shown to utilize endocannabinoids as substrates, and may have a key role in both the therapeutic and adverse effects of NSAIDs, as well as in NSAIDs-induced placebo responses.
Definition: An independent variable is the variable that is changed or controlled in a scientific experiment. Independent variables are the variables that the experimenter changes to test their dependent variable.
A scientific hypothesis is an inferred explanation of an observation or research finding; while more exploratory in nature than a theory, it is based on existing scientific knowledge. A scientific law is an expression of a mathematical or descriptive relationship observed in nature.