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In medicine, an indication is a valid reason to use a certain test, medication, procedure, or surgery.[1] The opposite of an indication is a contraindication,[2] a reason to withhold a certain medical treatment because it could harm a patient.
Difference in Definitions: The sign is what a physician or doctors see whereas symptom is what a patient experience and may not be verified. Difference in Indications: A sign of a disease is a definite indicator of that disease but symptoms could be one of the major characteristic of a disease. Subjective or Objective: