That's a little more than the typical 125 milligrams found in a cup of coffee. About 13 percent of the men reported leaky bladder, but only 4.5 percent had a problem considered moderate or severe - which is more than a few drops of urine leakage during the course of a month.
Irritability can be the result of a wide variety of other conditions, diseases or disorders that directly or indirectly affect the functioning of the brain and nervous system. These include intellectual decline, hypoxia and chronic pain. For more details about causes, see causes of irritability.
And also antidepressants can be major acid reflux contributors. for instance, I had never, ever been diagnosed with acid reflex until I started antidepressants. Now, here's the trip, while Valium sure can cause acid reflux, in my case, anxiety was producing way more acid than the anti-anxiety meds.