A cardinal feature of sarcoidosis is the presence of CD4+ T cells that interact with antigen-presenting cells to initiate the formation and maintenance of granulomas (Figure 2 Figure 2 Hypothesized Immunopathogenesis of Sarcoidosis.
Offset may refer to: 1  Offset (film), a 2006 film featuring RÄzvan Vasilescu and Alexandra Maria Lara. 2  Offset (law), a reduction in the amount to be paid by a losing party on the basis of debt owed by the prevailing party. 3  Offset agreement, a trade practice in the aerospace and defense industry.
Positive offset means that the mounting plate is in the outside half of the wheel, toward the wheel face. Most OEM wheels, and most wheels in general, will have a positive offset. Negative offset means the mounting plate is on the other side of the wheelâs centerline, farther toward the suspension. Negative offset is generally seen in very deep-dish or deep convex aftermarket wheels.