That's a little more than the typical 125 milligrams found in a cup of coffee. About 13 percent of the men reported leaky bladder, but only 4.5 percent had a problem considered moderate or severe - which is more than a few drops of urine leakage during the course of a month.
Irritability can be the result of a wide variety of other conditions, diseases or disorders that directly or indirectly affect the functioning of the brain and nervous system. These include intellectual decline, hypoxia and chronic pain. For more details about causes, see causes of irritability.
1 Higher doses can cause impairment of memory, judgment and coordination, irritability, paranoia,3 and suicidal thoughts. Some people experience the opposite of the intended effect, such as agitation or aggression.