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In domestic dogs, sexual maturity (puberty) occurs between the ages of 6 to 12 months for both males and females, although this can be delayed until up to two years of age for some large breeds. Pregnancy is possible as soon as the first estrus cycle, but breeding is not recommended prior to the second cycle.
Most female dogs will allow breeding around 10 to 16 days after start of the cycle. You should consider your pet to be in heat for 21 days: 7 days coming into heat, 7 days in heat, 7 days going out.Though conception is most likely during the middle 7 days.ost female dogs will allow breeding around 10 to 16 days after start of the cycle. You should consider your pet to be in heat for 21 days: 7 days coming into heat, 7 days in heat, 7 days going out.