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The driving distance between Knoxville, TN and Birmingham, AL is approximately 255 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non- â¦ stop in good driving conditions.
Distance from Memphis, TN to Birmingham, AL. There are miles from Memphis to Birmingham and miles by car. Memphis and Birmingham are far apart (by car). This is the best Memphis, TN-Birmingham, AL route.