Primary cold agglutinin disease is usually associated with monoclonal cold-reacting autoantibodies. Primary cold agglutinin disease is chronic and occurs after the fifth decade of life, with a peak incidence in the seventh and eighth decades. (See Epidemiology.) Secondary cold agglutinin disease may be associated with either monoclonal or polyclonal cold-reacting autoantibodies.
Microsoft was founded by Paul Allen and Bill Gates on April 4, 1975, to develop and sell BASIC interpreters for Altair 8800. It rose to dominate the personal computer operating system market with MS-DOS in the mid-1980s, followed by Microsoft Windows.
Childhood friends, Paul Allen and Bill Gates are the co-founders of Microsoft. The pair were total computer geeks in an age when any access to computers was hard to come by. Allen and Gates skipped classes to live and breathe in their school's computer room.