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Normal and diseased prions. Creutzfeldt-Jakob disease and its variants belong to a broad group of human and animal diseases known as transmissible spongiform encephalopathies (TSEs). The name derives from the spongy holes, visible under a microscope, that develop in affected brain tissue.The cause of Creutzfeldt-Jakob disease and other TSEs appears to be abnormal versions of a kind of protein called a prion.ormal and diseased prions. Creutzfeldt-Jakob disease and its variants belong to a broad group of human and animal diseases known as transmissible spongiform encephalopathies (TSEs). The name derives from the spongy holes, visible under a microscope, that develop in affected brain tissue.
Prion immunology and immunotherapy. Prion diseases like variant Creutzfeldt-Jakob disease (vCJD) in humans 1, BSE in cattle and scrapie in sheep are fatal brain diseases caused by an infectious agent, known as a prion.earch. Prion diseases like variant Creutzfeldt-Jakob disease (vCJD) in humans 1, BSE in cattle and scrapie in sheep are fatal brain diseases caused by an infectious agent, known as a prion.