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What are Mast Cells? Mast cells (MC) are immune system cells that live in the bone marrow and in body tissues, internal and external, such as the gastrointestinal tract, the lining of the airway, and the skin. Everyone has mast cells in their body, and they play many complex and critical roles in keeping us healthy.
Systemic mastocytosis (mas-to-sy-TOE-sis) is a rare disorder caused by a mutation that results in an excessive number of mast cells in your body. Mast cells normally help protect you from disease and aid in wound healing. But if you have systemic mastocytosis, excess mast cells can build up in various parts of your body. When triggered, these mast cells release substances that can overwhelm your body. You might experience symptoms such as facial flushing, itching, a rapid heartbeat, abdominal cramps, lightheadedness or even loss of consciousness. Common triggers include alcohol, temperature changes, spicy foods and certain medications.