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Causes. In cystic fibrosis, a defect (mutation) in a gene changes a protein that regulates the movement of salt in and out of cells. The result is thick, sticky mucus in the respiratory, digestive and reproductive systems, as well as increased salt in sweat.Many different defects can occur in the gene.n cystic fibrosis, a defect (mutation) in a gene changes a protein that regulates the movement of salt in and out of cells. The result is thick, sticky mucus in the respiratory, digestive and reproductive systems, as well as increased salt in sweat. Many different defects can occur in the gene.
The most common mutation (seen in approx. 70% of cystic fibrosis patients) that causes the disease is known as Delta F508.It affects the functions of a gene found in chromosome 7 called Cystic Fibrosis Transmembrane Regulator (CFTR) by displacing it from its normal location on the chromosome.0% of cystic fibrosis patients) that causes the disease is known as Delta F508. It affects the functions of a gene found in chromosome 7 called Cystic Fibrosis Transmembrane Regulator (CFTR) by displacing it from its normal location on the chromosome.