NSAIDs interact with the endocannabinoid system and its endocannabinoids, as COX2 have been shown to utilize endocannabinoids as substrates, and may have a key role in both the therapeutic and adverse effects of NSAIDs, as well as in NSAIDs-induced placebo responses.
Definition: An independent variable is the variable that is changed or controlled in a scientific experiment. Independent variables are the variables that the experimenter changes to test their dependent variable.
empirical. 1  derived from or guided by experience or experiment. 2  depending upon experience or observation alone, without using scientific method or theory, especially as in medicine. 3  provable or verifiable by experience or experiment.