NSAIDs interact with the endocannabinoid system and its endocannabinoids, as COX2 have been shown to utilize endocannabinoids as substrates, and may have a key role in both the therapeutic and adverse effects of NSAIDs, as well as in NSAIDs-induced placebo responses.
Definition: An independent variable is the variable that is changed or controlled in a scientific experiment. Independent variables are the variables that the experimenter changes to test their dependent variable.
A variable in an equation that may have its value freely chosen without considering values of any other variable. For equations such as y = 3x â 2, the independent variable is x. The variable y is not independent since it depends on the number chosen for x. Formally, an independent variable is a variable which can be assigned any permissible value without any restriction imposed by any other variable. See also.