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Cyanosis is a physical sign causing bluish discoloration of the skin and mucous membranes. Cyanosis is caused by a lack of oxygen in the blood. Cyanosis is associated with cold temperatures, heart failure, lung diseases, and smothering.yanosis. [sÄ«â²ÉnÅâ²sis]. Etymology: Gk, kyanos, blue, osis, condition. bluish discoloration of the skin and mucous membranes caused by an excess of deoxygenated hemoglobin in the blood or a structural defect in the hemoglobin molecule, such as in methemoglobin.
What Are the Common Underlying Causes of Cyanosis? Cyanosis can develop quickly or it can develop over time as a result of a chronic (long-term) health problem. Many of the health conditions that cause cyanosis are the result of abnormalities in the blood, lungs, or heart. Blood abnormalities may make it difficult for the blood to absorb oxygen. Lung abnormalities may be related to the following conditions: a blood clot in the vessels of the lung (pulmonary embolism)