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Normal and diseased prions. Creutzfeldt-Jakob disease and its variants belong to a broad group of human and animal diseases known as transmissible spongiform encephalopathies (TSEs). The name derives from the spongy holes, visible under a microscope, that develop in affected brain tissue.The cause of Creutzfeldt-Jakob disease and other TSEs appears to be abnormal versions of a kind of protein called a prion.ormal and diseased prions. Creutzfeldt-Jakob disease and its variants belong to a broad group of human and animal diseases known as transmissible spongiform encephalopathies (TSEs). The name derives from the spongy holes, visible under a microscope, that develop in affected brain tissue.
Report Abuse. A prion is now understood to be a 'rogue protein'. It is a protein that changes the conformation (or spatial structure) of other proteins when it comes into contact with them. The changes they induce can cause disease. Prions are believed to cause such diseases as 'Mad Cow' 'Kuru' and other diseases.Cannibalism once caused transmission of the proteins, and the disease is apparently transmissable from bovine to man through meat, particularly if nerve tissue is involved in the food processing. I hope this helps.he changes they induce can cause disease. Prions are believed to cause such diseases as 'Mad Cow' 'Kuru' and other diseases. Cannibalism once caused transmission of the proteins, and the disease is apparently transmissable from bovine to man through meat, particularly if nerve tissue is involved in the food processing.