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The driving distance between Knoxville, TN and Birmingham, AL is approximately 255 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non- â¦ stop in good driving conditions.
Knoxville is located at 40Â°54â²27â³N 90Â°16â²58â³Wï»¿ / ï»¿40.90750Â°N 90.28278Â°Wï»¿ / 40.90750; -90.28278 (40.907526, -90.282691). According to the 2010 census, the city has a total area of 2.32 square miles (6.0 km 2), all land.