If ACTH independent, it is due to the autonomous function of one or both adrenal glands, including adrenal adenomas, adrenocortical carcinomas, and micronodular or macronodular hyperplasia. The clinical manifestations of Cushing's syndrome are protean and reflect the catabolic actions of cortisol on skin, muscle, bone, liver, and fat.
Prior to pregnancy and into much of the third trimester your cervix is long and thick. As labor nears it begins to shorten and thin out. This action is referred to as effacement. Effacement is generally measured in percentages by doctors and midwives.
Acne is common during pregnancy. In fact, more than one out of every two pregnant women can expect to develop acne. In some cases, the acne may be severe. The primary cause of acne when you're pregnant is the increased hormone levels in the first trimester. The higher level increases the skin's production of natural oils. It's hard to predict who will develop pregnancy acne.