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The driving distance between Knoxville, TN and Birmingham, AL is approximately 255 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non- â¦ stop in good driving conditions.
Distance: 268.07 mi (431.42 km) The shortest distance (air line) between Chattanooga and Memphis is 268.07 mi (431.42 km). Driving route: -- (- ) The shortest route between Chattanooga and Memphis is according to the route planner. The driving time is approx. . Half of the trip is reached in . Flight route: 270.07 mi (434.63 km) (1h 0min) The flight distance between the nearest airports Chattanooga and Memphis is 270.07 mi (434.63 km).