You can use census records and voter lists to see where families with the Hoppringle surname lived over the years. While the questions in census records vary from place to place, and year to year, you can generally find information like name of household members, ages, birthplaces, residences, occupations, etc. Find out where people with the family name Hoppringle lived before coming to the United States. Using Ancestry, you can search through passenger arrival records, naturalization records, border crossings, emigration records, passport applications, and even convict transportation records.
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Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53) , is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). protein called Mdm2 (also called HDM2 in humans), binds to p53, preventing its action and transports it from the nucleus to the cytosol. Also Mdm2 acts as ubiquitin ligase and covalently attaches ubiquitin to p53 and thus marks p53 for degradation by the proteasome. However, ubiquitylation of p53 is reversible.