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The driving distance between Knoxville, TN and Birmingham, AL is approximately 255 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non- â¦ stop in good driving conditions.
Distance from Knoxville to ... Graph showing distances and directions to other locations. Click arrows to see the route on a map. Learn more about the distance graph. Created with RaphaÃ«l 2.1.0< 3992km >EWNSDhaka 8309 miNuuk 2366 miSt.