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The key difference between experimental and observational study is that an experimental study is a study where the researcher has control over most of the variables. On the other hand, an observation study is a study where the researcher merely observes the subject without controlling any variables.
Answer Wiki. There are no independent variables in observational studies. In an observational study, the researcher compares subjects against a control group and comes to a conclusion. Hypothetical example: if we have a research study comparing the risk of developing liver cancer between (1) people who drink some alcohol daily, and (2) teetotalers.