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Adrenergic Drugs Centrally acting alpha 2 agonist Clonidine, guanacine, methldopa Work by stimulating the alpha 2 receptors in the brain. These receptors actually reduce sympathetic outflow Secondly they affect the kidneys reducing the activity of renin. Decrease HR Alpha 2 agonists Side effects Peipheral edema,sedation,depression, Headache, dry mouth, decreased libido. Watch-out: Hepatotoxicity, Hemolytic anemia, granulocytopenia. Peripheral Acting Adrenergic drugs Alpha 1 blockers Doxazosin, prazosin, terazosin Dilate arteries and veins=low BP Also increase urinary flow rates and decrease outflow obstruction by preventing smooth muscle contraction in the bladder neck and urethra : BPH. Dosage must be increased gradually Q2wks Alpha 1 adrenergic antagonists Side Effects Orthostatic hypotension, dizziness, heachache, fatigue First-dose phenomenon, tachycardia,dyspnea Beta Blockers Beta cardioselective V.S. non-cardioselective? Beta blockers ending with âolol metoprolol, atenolol, propranolol, nadolol Watch-out for hypotension, CHF, bronchospasms, and impotence.