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Here's how to enlarge your veins and arteries for plasma donation: 1  Heat up your arm. When veins become overheated, they expand, and draw closer to the skin. 2  Hold off on drinking and smoking. Both smoking and drinking alcoholic beverages makes veins and arteries smaller and harder. 3  Hold off on the caffeine.
Quick Answer. Arteries have much thicker walls than other blood vessels in order to withstand the higher blood pressure that propels oxygenated blood away from the heart. Arteries are also supported by thick muscles and elastic fibers, unlike veins and capillaries, which are subjected to a much lower level of blood pressure. Keep Learning.