If ACTH independent, it is due to the autonomous function of one or both adrenal glands, including adrenal adenomas, adrenocortical carcinomas, and micronodular or macronodular hyperplasia. The clinical manifestations of Cushing's syndrome are protean and reflect the catabolic actions of cortisol on skin, muscle, bone, liver, and fat.
Prior to pregnancy and into much of the third trimester your cervix is long and thick. As labor nears it begins to shorten and thin out. This action is referred to as effacement. Effacement is generally measured in percentages by doctors and midwives.
Feeling unusually fatigued is an early pregnancy symptom that can occur as soon as one week after you conceive. The excessive tiredness is often related to a high level of progesterone in your system, although other things such as lower levels of blood sugar, lower blood pressure, and increased blood production can all contribute.