If ACTH independent, it is due to the autonomous function of one or both adrenal glands, including adrenal adenomas, adrenocortical carcinomas, and micronodular or macronodular hyperplasia. The clinical manifestations of Cushing's syndrome are protean and reflect the catabolic actions of cortisol on skin, muscle, bone, liver, and fat.
The words effacement, being effaced and effacing are terms that you will hear often as you approach your last trimester. These terms are used to describe the process that the cervix prepares itself for delivery and it is measured by percentage.
Puffy ankles are common during pregnancy and though it causes discomfort to you it is a sign that your pregnancy is going just the way it should be. Almost 3 in every 4 pregnant women experience edema, and it starts somewhere around weeks 22 and 27 of pregnancy.