NSAIDs interact with the endocannabinoid system and its endocannabinoids, as COX2 have been shown to utilize endocannabinoids as substrates, and may have a key role in both the therapeutic and adverse effects of NSAIDs, as well as in NSAIDs-induced placebo responses.
Definition: An independent variable is the variable that is changed or controlled in a scientific experiment. Independent variables are the variables that the experimenter changes to test their dependent variable.
Scientific observation, is to see the action of a thing, and to see  the effect of that action. Without action, you can not see. Without  difference, you can not distinguishâ¦. Without experimentation, you  can not physically divide.