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In domestic dogs, sexual maturity (puberty) occurs between the ages of 6 to 12 months for both males and females, although this can be delayed until up to two years of age for some large breeds. Pregnancy is possible as soon as the first estrus cycle, but breeding is not recommended prior to the second cycle.
In general, dogs neutered before they go into puberty grow a bit bigger than those neutered after puberty because testosterone is involved in bone growth; sometimes that growth is preferable and sometimes itâs not. Most dogs are sexually mature by the age of five or six months (the blink of an eye).If your dogâs testicles donât descend, you still need to have him neutered. These dogs tend to have more testicular tumors than normal dogs.ost dogs are sexually mature by the age of five or six months (the blink of an eye). If your dogâs testicles donât descend, you still need to have him neutered. These dogs tend to have more testicular tumors than normal dogs.