M1, M3 and M5 receptors cause the activation of phospholipase C, generating two secondary messengers (IP3 and DAG) eventually leading to an intracellular increase of calcium, while M2 and M4 inhibit adenylate cyclase, thereby decreasing the production of the second messenger cAMP.
Keep your dog healthy and parvo-free with these 8 tips: Make sure your dog is properly vaccinated. Puppies should receive their first vaccines at 6-8 weeks of age; boosters should be administered at three-week intervals until the puppy is 16 weeks of age, and then again at one year of age. Previously vaccinated adult dogs need boosters every year.
Expert: Tammy F. replied 9 years ago. If your dogs received three rounds of vaccines as puppies (around 8 weeks, 11 weeks and 16 weeks of age), they are somewhat protected until one year of age. At that time, they need boosters. Parvo is usually a juvenile disease, affecting the young and unvaccinated.