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Definition. Protein characteristic of the postsynaptic membrane. In a chemical synapse, the postsynaptic membrane is the membrane that receives a signal (binds neurotransmitter) from the presynaptic cell and responds via depolarisation or hyperpolarisation. The postsynaptic membrane is separated from the presynaptic membrane by the synaptic cleft.
This single EPSP does not sufficiently depolarize the membrane to generate an action potential. The summation of these three EPSPs generates an action potential. In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the neuron more likely to fire an action potential.