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Pituitary dependent hypercortisolism, more commonly known as Cushing's disease, is caused by a pituitary tumor (non-cancerous) that triggers excessive levels of the stress hormone cortisol.
Cushing's syndrome is the result of the excessive production of corticosteroids by the adrenal glands. An overproduction of corticotropin â the hormone that controls the adrenal gland â by the pituitary gland, which stimulates the adrenal glands to produce corticosteroids, may be one cause of Cushing's disease.reatment for Cushing's syndrome depends on its cause. Surgery may be needed to remove the tumor or the pituitary or adrenal glands. Other treatment may include radiation, chemotherapy, and use of certain hormone-inhibiting drugs.