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TRH stimulation test. Prior to the availability of sensitive TSH assays, thyrotropin releasing hormone (TRH) stimulation tests were relied upon for confirming and assessing the degree of suppression in suspected hyperthyroidism. Typically, this stimulation test involves determining basal TSH levels and levels 15 to 30 minutes after an intravenous bolus of TRH.
Thyroid Hormone Receptors. Thyroid hormones act by binding to cytosolic receptors of the steroid-thyroid hormone receptor superfamily (nuclear receptors) identified as thyroid hormone receptors (TR). There are two TR receptors designated TRÎ± and TRÎ² encoded by the THRA and THRB genes, respectively.ecause of its relatively lower potency, testosterone is sometimes considered to be a prohormone. Synthesis of the male sex hormones in Leydig cells of the testis. P450SSC, 3Î²-DH, and P450c17 are the same enzymes as those needed for adrenal steroid hormone synthesis.