Causes of Granuloma. A granuloma is most often caused by inflammation of a small area of tissue from injury or infection. List of causes of Granuloma. Following is a list of causes or underlying conditions (see also Misdiagnosis of underlying causes of Granuloma) that could possibly cause Granuloma includes: Granuloma annulare - a skin condition.
Bisphosphonates and cancer. Bisphosphonates are drugs that slow down or prevent bone damage. They also lower calcium levels. How cancer can affect the bones. Some cancers can cause bone pain and weakness. These are most often cancers that have started in another part of the body and have spread to the bone (secondary bone cancer).
Its most commonly reported side-effect is a 10% incidence of upper GI symptoms including heartburn or gastroesophageal reflux. The dosing schedule and potential side-effect limit the use of this drug in some patients. One way to potentially achieve the benefits of a bisphosphonate without the GI side-effects or dosing issues is to use an intravenous bisphosphonate. Pamidronate, another bisphosphonate commonly used in the treatment of elevated calcium levels associated with cancer, can be used for the treatment of osteoporosis. It is often given intravenously at three month intervals and has been shown in several small studies to reduce the rates of bone loss.