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The initial symptoms of liver failure are often ones that can be due to any number or conditions. Because of this, liver failure may be initially difficult to diagnose. Early symptoms include: 1  Nausea. 2  Loss of appetite. 3  Fatigue.he initial symptoms of liver failure are often ones that can be due to any number or conditions. Because of this, liver failure may be initially difficult to diagnose. Early symptoms include: 1  Nausea. 2  Loss of appetite. 3  Fatigue.
353,820 Helpful Votes. 388 Followers. A. In most cases, a slightly enlarged liver causes no symptoms. However, if your liver becomes severely enlarged, you may have: 1  A feeling of fullness. 2  Abdominal discomfort. 3  With liver disease, you may have other symptoms, such as jaundice, fatigue, weakness, nausea, and weight loss.