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The main target organs where parathyroid hormone exerts its effects are the bones and the kidneys. When needed, parathyroid hormone is released by the parathyroid glands into the blood and causes the bones to release calcium and increase levels in the bloodstream.
Like other organs and glands in the body, the parathyroid is vulnerable to disease. 1  One common disease that affects the parathyroid gland is primary hyperparathyroidism, which is characterized by a hyperfunctioning parathyroid gland and an overproduction of the PTH hormone. 2  Rarely, a cancer of the parathyroid gland is the cause.