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Definition. Protein characteristic of the postsynaptic membrane. In a chemical synapse, the postsynaptic membrane is the membrane that receives a signal (binds neurotransmitter) from the presynaptic cell and responds via depolarisation or hyperpolarisation. The postsynaptic membrane is separated from the presynaptic membrane by the synaptic cleft.
1 The membrane consists of a double-layer (a phospholipid bilayer) of amphipathic lipids. The hydrophobic ends face each other on the inside, and the hydrophilic ends are on the outsides of the membrane. 2  Other molecules are also found in the membrane. For example, other lipids, such as cholesterol, may be present.