M1, M3 and M5 receptors cause the activation of phospholipase C, generating two secondary messengers (IP3 and DAG) eventually leading to an intracellular increase of calcium, while M2 and M4 inhibit adenylate cyclase, thereby decreasing the production of the second messenger cAMP.
Keep your dog healthy and parvo-free with these 8 tips: Make sure your dog is properly vaccinated. Puppies should receive their first vaccines at 6-8 weeks of age; boosters should be administered at three-week intervals until the puppy is 16 weeks of age, and then again at one year of age. Previously vaccinated adult dogs need boosters every year.
At 12 and 15 weeks, a combination vaccine is given. After these puppy parvovirus vaccinations, the dog will receive a booster shot every year as an adult â or every 3 years depending on your vetâs vaccination preferences.he Lyme disease vaccination is usually only give to dogs in areas where Lyme disease is a concern. It is given at 12 and 15 weeks and again at 12 months. Booster shots can be given annually if recommended by your vet.