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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
Tweet. Share this. What causes lymphoma is not well known. DNA mutations may be what causes lymphoma to develop but what triggers these mutations is largely unknown. Family history does not provide much of a clue; except in the case of some rare forms, lymphoma does not appear to be linked to genetic inheritance. However, as lymphoma incidence rises and research accelerates, several risk factors for lymphoma have been established. We outline some of them below.