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Prevalance of Scleroderma: Estimates for the number of people in the United States with systemic sclerosis range from 40,000 to 165,000. By contrast, a survey that included all scleroderma-related disorders, including Raynaud's phenomenon, suggested a number between 250,000 and 992,500.bout prevalence and incidence statistics: The term 'prevalence' of Scleroderma usually refers to the estimated population of people who are managing Scleroderma at any given time.
Scleroderma is classified as localized or widespread (systemic sclerosis with a tendency to affect internal organs). Systemic sclerosis is further divided into limited and diffuse based upon the extent of skin involvement. Scleroderma is a disease of the connective tissue featuring skin thickening that can involve scarring, blood vessel problems, varying degrees of inflammation, and is associated with an overactive immune system. 2  CREST syndrome is a limited form of systemic sclerosis.