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Pituitary dependent hypercortisolism, more commonly known as Cushing's disease, is caused by a pituitary tumor (non-cancerous) that triggers excessive levels of the stress hormone cortisol.
Causes of Cushingâs Disease. Cushingâs disease is caused by an excess of freely circulating corticosteroid hormones, which are produced by the adrenal glands.The adrenal glands are tiny, paired structures located in the abdomen above each kidney.auses of Cushingâs Disease. Cushingâs disease is caused by an excess of freely circulating corticosteroid hormones, which are produced by the adrenal glands.