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pepsinogen. a zymogen secreted by the chief cells of the gastric glands and converted into pepsin in the presence of gastric acid or of pepsin itself.plasma pepsinogen. high levels are indicative of extensive mucosal damage in the abomasum, as in ostertagiasis in ruminants. proenzyme formed and secreted by the chief cells of the gastric mucosa; the acidity of the gastric juice and pepsin itself remove 42 amino acid residues from pepsinogen to form active pepsin. Synonym(s): propepsin. [ pepsin + G. -gen, producing].
1 There, in the acid environment of the stomach, pepsinogen is converted into pepsin. 2  Trypsin is a protease secreted into the small intestine by the pancreas. 3  As pepsin, trypsin digests proteins into peptides and amino acids and is made and secreted in an inactive form, trypsinogen.