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Pituitary dependent hypercortisolism, more commonly known as Cushing's disease, is caused by a pituitary tumor (non-cancerous) that triggers excessive levels of the stress hormone cortisol.
Cushing's disease is a rare condition caused by an overproduction of the adrenal hormone cortisol. The most common form of Cushing's disease is due to an excess secretion of the pituitary hormone, ACTH (adrenocorticotropic hormone), which circulates in the blood and stimulates the adrenal gland.ituitary disorders. The pituitary is a small gland (about the size of a kidney bean) located at the base of the brain, just beneath the optic (eye) nerve in a bony area called the sella turcica.