Dangers and Long-Term Effects of Cocaine Abuse. Risk of overdose, damage to the nose and nasal passages, what are the long term effects of use? Cocaine addicts can develop a chronic runny nose and find that their ability to smell is impaired, and their ability to taste also decreased.
Delayed cerebral ischaemia. Delayed cerebral ischaemia, or vasospasm, is another serious and common complication of a subarachnoid haemorrhage. This is when the supply of blood to the brain becomes dangerously low, disrupting the normal functions of the brain and causing brain damage. It's most common a few days after the first haemorrhage.
The vasoconstrictor polypeptide hormone, angiotensin II, which is released by the action of the enzyme renin. Its precursor, angiotensin I, is inactive until acted on by the angiotensin-converting enzyme, mainly in the lungs. Angiotensin II has a powerful effect on raising the blood pressure. It binds to angiotensin receptors and constricts the circular smooth muscle of blood vessel walls.