Open the combination lock using the old combination. Remove the u-bar from the lock body so it's in the Unlock position. Use a screwdriver to open the anti-dust cover on the back of the combination lock. Align the old combination numbers to the guide points.
A base pair (bp) is a unit consisting of two nucleobases bound to each other by hydrogen bonds. They form the building blocks of the DNA double helix, and contribute to the folded structure of both DNA and RNA.
Base substitution. Base substitutions are the simplest type of gene-level mutation, and they involve the swapping of one nucleotide for another during DNA replication. For example, during replication, a thymine nucleotide might be inserted in place of a guanine nucleotide.