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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
Acquired lymphocytopenia. Acquired lymphocytopenia can occur with a number of other disorders (see Table: Causes of Lymphocytopenia). The most common causes include. Protein-energy undernutrition. AIDS and certain other viral infections. Protein-energy undernutrition is the most common cause worldwide. AIDS is the most common infectious disease causing lymphocytopenia, which arises from destruction of CD4+ T cells infected with HIV. Lymphocytopenia may also reflect impaired lymphocyte production arising from destruction of thymic or lymphoid architecture.