M1, M3 and M5 receptors cause the activation of phospholipase C, generating two secondary messengers (IP3 and DAG) eventually leading to an intracellular increase of calcium, while M2 and M4 inhibit adenylate cyclase, thereby decreasing the production of the second messenger cAMP.
Keep your dog healthy and parvo-free with these 8 tips: Make sure your dog is properly vaccinated. Puppies should receive their first vaccines at 6-8 weeks of age; boosters should be administered at three-week intervals until the puppy is 16 weeks of age, and then again at one year of age. Previously vaccinated adult dogs need boosters every year.
But with puppies, getting their rounds of vaccines is crucial. For instance, if a puppy catches Parvo, he has less than a 20% chance of recovery. So, put your pup's vaccine dates on your schedule and send yourself reminders. This tip has a list of necessary vaccines for the first round and further tips will cover the next two rounds. Vets and local laws differ a bit about exactly what to give when so use these tips as guidelines and follow your vet's advice. The vaccines to give at this age are 1. Distemper 2.