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Pituitary dependent hypercortisolism, more commonly known as Cushing's disease, is caused by a pituitary tumor (non-cancerous) that triggers excessive levels of the stress hormone cortisol.
How long do dogs live with Cushing's Disease? Cushingâs disease is caused by an overproduction of cortisol by the adrenal glands. It develops because of the presence of a tumor in one of the adrenal glands or in the pituitary gland in the brain. Early signs of Cushingâs disease include excessive thirst, urination and appetite.