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When an enzyme binds its substrate, it forms an enzyme-substrate complex. This complex lowers the activation energy of the reaction and promotes its rapid progression by providing certain ions or chemical groups that actually form covalent bonds with molecules as a necessary step of the reaction process.
For an enzyme to work it must bind to a specific substrate molecule, using a part of the enzyme molecule called the active site. To do this, the enzyme's active site and the s â¦ ubstrate must have matching (complementary) shapes.The shape of an enzyme molecule depends on the exact way in which the molecule folds up.When enzymes are heated the weak bonds which hold the molecules in their precise shape are broken, and the enzyme molecule unwinds into a random shape. It can no longer bind with its substrate so it no longer has any activity.This unwinding of a protein molecule is called denaturation.hen enzymes are heated the weak bonds which hold the molecules in their precise shape are broken, and the enzyme molecule unwinds into a random shape. It can no longer bind with its substrate so it no longer has any activity. This unwinding of a protein molecule is called denaturation.