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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
1 Other causes include inflammation and cancers. There is a wide variety of infections from a strep throat or ear infection, to mononucleosis or HIV infection, which can cause swelling of lymph nodes.  Lymphoma and leukemia cause swelling of lymph nodes, and many cancers spread to lymph nodes.