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Prevalance of Scleroderma: Estimates for the number of people in the United States with systemic sclerosis range from 40,000 to 165,000. By contrast, a survey that included all scleroderma-related disorders, including Raynaud's phenomenon, suggested a number between 250,000 and 992,500.bout prevalence and incidence statistics: The term 'prevalence' of Scleroderma usually refers to the estimated population of people who are managing Scleroderma at any given time.
1 Anti-centromere antibodies usually occur with a less severe form of the disease. 2  Higher-than-normal levels of autoantibodies to fibrillin 1, a protein found in muscle and other connective tissues, is more common in patients with both systemic and localized scleroderma.