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Pituitary dependent hypercortisolism, more commonly known as Cushing's disease, is caused by a pituitary tumor (non-cancerous) that triggers excessive levels of the stress hormone cortisol.
It is caused by overproduction of the hormone cortisol. There are a variety of causes of this disorderâa tumor in the adrenal gland or pituitary gland could be to blame. To learn more, read our article about Cushing's syndrome. Congenital adrenal hyperplasia: This genetic disorder is characterized by low levels of cortisol.