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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
What Causes Non-Hodgkin Lymphoma? Researchers have found that non-Hodgkin lymphoma (NHL) is linked with a number of risk factors, but the cause of most lymphomas ais not known. This is complicated by the fact that lymphomas are actually a diverse group of cancers. Still, scientists have made a lot of progress in understanding how certain changes in DNA can cause normal lymphocytes to become lymphoma cells.