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Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.n similar manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over another, and, although most of these agents do act as D 2 agonists, they affect other subtypes as well.
Dopamine Receptors â¢ Five subtypes of dopamine receptor havebeen cloned. The D1 andD5 receptors are closelyrelated, and couple to Gs alpha and stimulateadenylyl cyclase activity. In contrast, the D2, D3 and D4 receptors coupleto Gi alpha and inhibit theformation of cAMP.opamine Receptors â¢ There are five types of dopamine receptors.D1,D2,D3,D4,D5.â¢ We can catogorize dopamine receptors in two two main subtypes: â¢ D1 like receptor family: the Gs protein is involved and adenylyl cyclase would be activated.