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The main target organs where parathyroid hormone exerts its effects are the bones and the kidneys. When needed, parathyroid hormone is released by the parathyroid glands into the blood and causes the bones to release calcium and increase levels in the bloodstream.
Parathyroid hormone influences the levels of both calcium and phosphorus in the body. A portion of PTH is split into 3 fragments in the parathyroid gland before systemic release.The 3 fragments are an amino or N-terminal fragment, a midregion fragment, and a carboxy or C-terminal fragment.The active intact PTH and the amino terminal fragment are physiologically active in the body. portion of PTH is split into 3 fragments in the parathyroid gland before systemic release. The 3 fragments are an amino or N-terminal fragment, a midregion fragment, and a carboxy or C-terminal fragment. The active intact PTH and the amino terminal fragment are physiologically active in the body.