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The main target organs where parathyroid hormone exerts its effects are the bones and the kidneys. When needed, parathyroid hormone is released by the parathyroid glands into the blood and causes the bones to release calcium and increase levels in the bloodstream.
How parathyroid hormone works. Like in the thyroid, the parathyroids have receptors (in this case calcium receptors) that detect the level of calcium in the body. Parathyroid hormone (PTH) is released when these calcium receptors (CaR) on the surface of the parathyroid glands detect low blood calcium levels.ow parathyroid hormone works. Like in the thyroid, the parathyroids have receptors (in this case calcium receptors) that detect the level of calcium in the body. Parathyroid hormone (PTH) is released when these calcium receptors (CaR) on the surface of the parathyroid glands detect low blood calcium levels.