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When an enzyme binds its substrate, it forms an enzyme-substrate complex. This complex lowers the activation energy of the reaction and promotes its rapid progression by providing certain ions or chemical groups that actually form covalent bonds with molecules as a necessary step of the reaction process.
Enzyme-substrate Complex. In a chemical reaction, the step wherein a substrate binds to the active site of an enzyme is called an enzyme-substrate complex. The activity of an enzyme is influenced by certain aspects such as temperature, pH, co-factors, activators, and inhibitors.Advertisement.n a chemical reaction, the step wherein a substrate binds to the active site of an enzyme is called an enzyme-substrate complex. The activity of an enzyme is influenced by certain aspects such as temperature, pH, co-factors, activators, and inhibitors. Advertisement.