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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
Because swelling is sometimes a sign of cancer, it is also important to see your doctor to be sure the cancer has not come back. Causes of lymphedema. Lymphedema is usually a predictable long-term side effect of some cancer treatments. The most common causes of lymphedema in cancer survivors include: Surgery in which lymph nodes were removed. For example, surgery for breast cancer often involves removing 1 or more lymph nodes under the arm to check for cancer. This can cause lymphedema in the arm. Radiation therapy or other causes of inflammation or scarring in the lymph nodes and lymph vessels. Blockage of the lymph nodes and/or lymph vessels by the cancer. The risk of lymphedema increases with the number of lymph nodes and lymph vessels removed or damaged during cancer treatment or biopsies.