Signs and symptoms. 1  Cognitive effects: headache, agitation, hypomania, mental confusion, hallucinations, coma. 2  Autonomic effects: shivering, sweating, hyperthermia, vasoconstriction, tachycardia, nausea, diarrhea. 3  Somatic effects: myoclonus (muscle twitching), hyperreflexia (manifested by clonus), tremor.
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