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Pituitary dependent hypercortisolism, more commonly known as Cushing's disease, is caused by a pituitary tumor (non-cancerous) that triggers excessive levels of the stress hormone cortisol.
Cushing's syndrome facts*. *Cushing's syndrome facts by John P. Cunha, DO, FACOE. 1  Cushing's syndrome, or hypercortisolism, is a relatively rare hormonal disorder caused by prolonged exposure of the body's tissues to high levels of the hormone cortisol. It may also develop because of overproduction of cortisol by the body, or adrenal tumors. 2  Cushing's syndrome is diagnosed with tests such as the 24-hour urinary free cortisol level test, the dexamethasone suppression test, the CRH stimulation test, CT scan or MRI, and the dexamethasone-CRH test.