Sphere of influence. In the field of international relations, a sphere of influence (SOI) is a spatial region or concept division over which a state or organization has a level of cultural, economic, military, or political exclusivity, accommodating to the interests of powers outside the borders of the state that controls it.
Multiple myeloma is named for the clock face appearance of these cancer cells when seen under a microscope. They infiltrate virtually all of a patient's bone marrow. In x-ray images of multiple myeloma, it looks like holes have been punched out of the bone.
Or, these symptoms may be caused by a medical condition that is not cancer. Anemia is a low level of red blood cells, which happens when myeloma plasma cells suppress or crowd out healthy red blood cells. Fatigue is usually caused by anemia and occurs in most people with myeloma. Bone pain is a common symptom. Myeloma cells grow in the bone marrow, the spongy tissue inside of the bone, and cause local bone damage or generalized thinning of the bone, called osteoporosis. This makes the bone more likely to break. The back or ribs are the most common sites of bone pain, but any bone can be affected.