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Population of Middletown, OH. Last official estimated population of Middletown city (Butler County**, Ohio state) was 48,791 (year 2014)[1]. This was 0.015% of total US population and 0.42% of total Ohio state population. Area of Middletown city is 26.4 miÂ² (=68.4 kmÂ²)[6], in this year population density was 1,846.81 p/miÂ².
From Ohio History Central. Somerset, which was once known as Middletown, was formerly the county seat of Perry County, Ohio. In 1807, John Finck erected the first log cabin in what would become Somerset. Several years later, Jacob Miller arrived, becoming the second settler in this community.