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Population of Middletown, OH. Last official estimated population of Middletown city (Butler County**, Ohio state) was 48,791 (year 2014)[1]. This was 0.015% of total US population and 0.42% of total Ohio state population. Area of Middletown city is 26.4 miÂ² (=68.4 kmÂ²)[6], in this year population density was 1,846.81 p/miÂ².
Middletown, Ohio is conveniently situated between the Cincinnati and Dayton metro areas, in Northeast Butler County, and hosts some the most exciting annual events in Southwest Ohio. Learn more about staying and playing in Middletown, OH: Arts & Theatre.