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General Pharmacology. Beta-adrenoceptor agonists (Î²-agonists) bind to Î²-receptors on cardiac and smooth muscle tissues. They also have important actions in other tissues, especially bronchial smooth muscle (relaxation), the liver (stimulate glycogenolysis) and kidneys (stimulate renin release). Beta-adrenoceptors normally bind to norepinephrine released by sympathetic adrenergic nerves, and to circulating epinephrine.
Norepinephrine is also made in the adrenal medulla where it synthesized from dopamine and is released into the blood as a hormone. Epinephrine is made from norepinephrine inside the adrenal medulla (the inner part of the adrenal gland, a small gland associated with the kidneys). Our adrenal medulla helps us to cope with physical and emotional stress. The synthesis of epinephrine increases during times of stress.