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Canker sores may also occur because of certain conditions and diseases, such as: 1  Celiac disease, a serious intestinal disorder caused by a sensitivity to gluten, a protein found in most grains. 2  Inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis.
Canker sores don't involve the herpes virus and aren't contagious. No one knows what causes them. Cold sores generally herald their arrival with a warning period of red, irritated skin. Blisters form, rupture, and then crust over before healing.