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ESBL stands for Extended-Spectrum beta-Lactamase. Beta lactamases are enzymes that are produced by many types of bacteria (germs) which make them more resistant to antibiotics and can make the infection harder to treat.
References: Bartlett JG, Auwaerter PG, Pham PA (2010): The Johns Hopkins ABX Guide. Diagnosis and Treatment of Infectious Diseases. 2010 2nd Edition. Jones & Bartlett Publishers, Sudbury MA. (ISBN: 978-0-7637-8108-8) Deck DH, Winston LG (2012): Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics (Chapter 43).