Cushing's syndrome is the result of the excessive production of corticosteroids by the adrenal glands. An overproduction of corticotropin (ACTH) - the hormone that controls the adrenal gland - by the pituitary gland, which stimulates the adrenal glands to produce corticosteroids, may be one cause. It is called Cushing's disease and the result of ACTH-secreting pituitary adenoma. Alt.
deficiency. a lack or shortage; a condition characterized by the presence of less than the normal or necessary supply or competence. color vision deficiency see color vision deficiency.
Princeton's WordNet(5.00 / 1 vote)Rate this definition: 1  hopeless(adj) without hope because there seems to be no possibility of comfort or success. 2  hopeless(adj) of a person unable to do something skillfully. 3  hopeless(adj) certain to fail.  hopeless(adj) (informal to emphasize how bad it is) beyond hope of management or reform.