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Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates. Importantly, S. aureus is generally coagulase-positive, meaning that coagulase negativity usually excludes S. aureus. However it is now known that not all S. aureus are coagulase-positive.
1 coagulase test. 2  Coagulase-negative. 3  Coagulase-Negative Staphylococcal. 4  Coagulase-Negative Staphylococci. 5  Coagulase-Negative Staphylococci Bacteraemia. 6  coagulase-negative Staphylococcus species. 7  coagulase-positive staphylococcus. 8  coagulase-positive staphylococcus. 9  coagulase-positive staphylococcus.oagulase test. enzymatic conversion of fibrinogen in rabbit plasma to fibrin is used as a means of identifying pathogenic species of staphylococci. The test may be carried out rapidly on a slide or in several hours or overnight in a tube.