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As a general rule, antibiotics do not cause a decrease of white blood cells (WBCs). WBCs are one of the main ways the body fights infection. Because your son had a recent illness the WBC count most likely increased during that period in order to fight his infection.
White blood cells increase with inflammation -- a normal and helpful immune function that helps healing. However, chronic or long-term inflammation can promote the development diseases such as diabetes, cancer and heart disease. Unhealthy lifestyle behaviors are known to increase inflammation -- and white cell counts.