manifest. 1  readily perceived by the eye or the understanding; evident; obvious; apparent; plain: a manifest error. 2  Psychoanalysis. of or relating to conscious feelings, ideas, and impulses that contain repressed psychic material: the manifest content of a dream as opposed to the latent content that it conceals.
In medicine, an adverse effect is an undesired harmful effect resulting from a medication or other intervention such as surgery. An adverse effect may be termed a  side effect , when judged to be secondary to a main or therapeutic effect.
Drug induced Lupus Drug induced lupus (DIL) is a side effect of long term use of certain medications. These drugs cause an autoimmune response (the body attacks its own cells) producing symptoms similar to those of SLE, but it is not generally as severe as SLE.