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Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates. Importantly, S. aureus is generally coagulase-positive, meaning that coagulase negativity usually excludes S. aureus. However it is now known that not all S. aureus are coagulase-positive.
Noun. 1. coagulation-the process of forming semisolid lumps in a liquid. clotting, curdling. blood clotting, blood coagulation-a process in which liquid blood is changed into a semisolid mass (a blood clot).oun. 1. coagulation-the process of forming semisolid lumps in a liquid. clotting, curdling. blood clotting, blood coagulation-a process in which liquid blood is changed into a semisolid mass (a blood clot).