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Canker sores may also occur because of certain conditions and diseases, such as: 1  Celiac disease, a serious intestinal disorder caused by a sensitivity to gluten, a protein found in most grains. 2  Inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis.
1 Canker sores can recur, and can be minor (small), major (larger) or herpetiform (multiple, in groups or clusters).  Canker sores are common and often recur. Although the exact cause is uncertain, some experts believe that immune system problems, bacteria or viruses may be involved.