Mutations in the ABCA12 gene cause harlequin ichthyosis. The ABCA12 gene provides instructions for making a protein that is essential for the normal development of skin cells. This protein plays a major role in the transport of fats (lipids) in the outermost layer of skin (the epidermis).
Uses of Boron. 1  Much boron is made into sodium tetraborate which is used to insulate fiberglass. 2  It is also used in many cleaning products-detergents and bleaches. 3  Most boron is used to produce glass and ceramics. It is also used in many cleaning products-detergents and bleaches. 2  Most boron is used to produce glass and ceramics. 3  Borosilicate glass has a fantastic resistance to thermal shock (sudden changes in temperature which causes glass to break).
Boron is a naturally occurring element. In the environment, boron is combined with oxygen and other elements in compounds called borates. Borates are widely found in nature, and are present in oceans, sedimentary rocks, coal, shale and some soils.