Note 2: Denaturation can occur when proteins and nucleic acids are subjected to elevated temperature or to extremes of pH, or to nonphysiological concentrations of salt, organic solvents, urea, or other chemical agents. Note 3: An enzyme loses its catalytic activity when it is denaturized.ote 2: Denaturation can occur when proteins and nucleic acids are subjected to elevated temperature or to extremes of pH, or to nonphysiological concentrations of salt, organic solvents, urea, or other chemical agents. Note 3: An enzyme loses its catalytic activity when it is denaturized.
List of Major League Baseball single-game hits leaders. Wilbert Robinson (left) and Rennie Stennett (not pictured) hold the record for most hits in a nine-inning game with seven, while Cal McVey (right) amassed six hits in each of two consecutive games.
This being said, to amass more than 4,000 hits is one of Major League Baseballâs rarest accomplishments. In 1921, Ty Cobb set the mark with 4,191 hits, a record that stood for more than five decades. On this day, September 11th, in 1985, Pete Rose broke Ty Cobbs all-time hits record with his 4,192nd hit. The record came against San Diego Padres pitcher Eric Show. It was a single to left-center field.