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The major difference between prophase I and prophase II is the genetic recombination process that occurs during prophase I, but does not repeat in prophase II. During prophase I, the duplicated... The major difference between prophase I and prophase II is the genetic recombination process that occurs during prophase I, but does not repeat in prophase II.
Meiosis I consists of four phases: prophase I, metaphase I, anaphase I, and telophase I. Figure 1: Recombination is the exchange of genetic material between homologous chromosomes. During prophase I, the chromosomes condense and become visible inside the nucleus. Because each chromosome was duplicated during the S phase that occurred just before prophase I, each now consists of two sister chromatids joined at the centromere.