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Population of Middletown, OH. Last official estimated population of Middletown city (Butler County**, Ohio state) was 48,791 (year 2014)[1]. This was 0.015% of total US population and 0.42% of total Ohio state population. Area of Middletown city is 26.4 miÂ² (=68.4 kmÂ²)[6], in this year population density was 1,846.81 p/miÂ².
People in group quarters in Middletown in 2000: 1  557 people in nursing homes. 2  495 people in mental (psychiatric) hospitals or wards. 3  212 people in training schools for juvenile delinquents.  193 people in other noninstitutional group 1  quarters. 160 people in hospitals or wards for drug/alcohol abuse.