Do not take more than three doses (36 mg) of tizanidine in a 24-hour period. Too much of this medication can damage your liver. Cold or allergy medicine, narcotic pain medicine, sleeping pills, other muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tizanidine.Tell your doctor if you need to use any of these other medicines together with tizanidine.Avoid drinking alcohol.old or allergy medicine, narcotic pain medicine, sleeping pills, other muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tizanidine. Tell your doctor if you need to use any of these other medicines together with tizanidine. Avoid drinking alcohol.
If there are many more acidic residues than basic ones, the protein will have an overall negative charge. ....it is the phosphate groups that contain a negatively charged oxygen atom that make the DNA n RNA molecules negatively charged......
DNA has a double-helix structure, with sugar and phosphate on the outside of the helix, forming the sugar-phosphate backbone of the DNA. The nitrogenous bases are stacked in the interior in pairs, like the steps of a staircase; the pairs are bound to each other by hydrogen bonds. The two strands of the helix run in opposite directions. This antiparallel orientation is important to DNA replication and in many nucleic acid interactions. DNA is a Double Helix: Native DNA is an antiparallel double helix. The phosphate backbone (indicated by the curvy lines) is on the outside, and the bases are on the inside. Each base from one strand interacts via hydrogen bonding with a base from the opposing strand.