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Canker sores may also occur because of certain conditions and diseases, such as: 1  Celiac disease, a serious intestinal disorder caused by a sensitivity to gluten, a protein found in most grains. 2  Inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis.
A cold sore often begins as several tiny blisters that eventually form one larger sore. They appear most often on the lips and face. In contrast, canker sores usually travel alone. And unlike a sore caused by the herpes virus, a canker sore is not contagious. A canker sore has a yellow or white-gray center with a well-defined red border.