Penalty for Non-Qualified Distributions. Distributions not used for qualified medical expenses are includable in gross income and, for applicants under age 65, subject to an additional 10% tax.
Binding of Epinephrine to Adrenergic Receptors Induces Tissue-Specific Responses. Epinephrine and norepinephrine were originally recognized as products of the medulla, or core, of the adrenal gland and are also known as adrenaline and noradrenaline.
Examples are the class of nuclear receptors located in the cell nucleus and cytoplasm and the IP3 receptor located on the endoplasmic reticulum. The ligands that bind to them are usually intracellular second messengers like inositol trisphosphate (IP3) and extracellular lipophilic hormones like steroid hormones. Some intracrine peptide hormones also have intracellular receptors.