manifest. 1  readily perceived by the eye or the understanding; evident; obvious; apparent; plain: a manifest error. 2  Psychoanalysis. of or relating to conscious feelings, ideas, and impulses that contain repressed psychic material: the manifest content of a dream as opposed to the latent content that it conceals.
In medicine, an adverse effect is an undesired harmful effect resulting from a medication or other intervention such as surgery. An adverse effect may be termed a  side effect , when judged to be secondary to a main or therapeutic effect.
Medicines That May Cause Swelling. Swelling can be a sign that you are having an allergic reaction to a medicine. This can happen with almost any medicine. Many prescription and nonprescription medicines also may cause swelling as a side effect. A few examples are: 1  Corticosteroids. 2  Hormones, such as birth control pills and hormone therapy used to treat menopause symptoms. 3  Some blood pressure medicines.