Rheumatoid arthritis is a serious autoimmune disease that attacks the joints and other body parts. But RA can be tough to diagnose. Symptoms can mimic other illnesses, or they may flare, then fade, only to flare again somewhere else. Lab tests arenât perfectyou can test negative for RA factors and still have it.heumatoid arthritis is a serious autoimmune disease that attacks the joints and other body parts. But RA can be tough to diagnose. Symptoms can mimic other illnesses, or they may flare, then fade, only to flare again somewhere else. Lab tests arenât perfectyou can test negative for RA factors and still have it.
People with pyruvate dehydrogenase deficiency usually have neurological problems as well. Most have delayed development of mental abilities and motor skills such as sitting and walking. Other neurological problems can include intellectual disability, seizures, weak muscle tone (hypotonia), poor coordination, and difficulty walking.
A deficiency of lipoic acid, the E2 enzyme cofactor, has been described. A deficiency of the E2 enzyme has been described. The gene for the X protein of the pyruvate dehydrogenase complex is located at 11p13 and has an autosomal recessive inheritance.Eleven cases of pyruvate dehydrogenase complex X protein deficiency have been documented. The E3 enzyme is mapped to 7q31-32 and has an autosomal recessive inheritance. deficiency of lipoic acid, the E2 enzyme cofactor, has been described. A deficiency of the E2 enzyme has been described. The gene for the X protein of the pyruvate dehydrogenase complex is located at 11p13 and has an autosomal recessive inheritance.