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Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates. Importantly, S. aureus is generally coagulase-positive, meaning that coagulase negativity usually excludes S. aureus. However it is now known that not all S. aureus are coagulase-positive.
coÂ·agÂ·uÂ·laÂ·tion. 1. Clotting; the process of changing from a liquid to a solid, said especially of blood (that is, blood coagulation). In vertebrates, blood coagulation is a result of cascade regulation from fibrin. 2.A clot or coagulum.oÂ·agÂ·uÂ·laÂ·tion. 1. Clotting; the process of changing from a liquid to a solid, said especially of blood (that is, blood coagulation). In vertebrates, blood coagulation is a result of cascade regulation from fibrin. 2.