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The major difference between prophase I and prophase II is the genetic recombination process that occurs during prophase I, but does not repeat in prophase II. During prophase I, the duplicated... The major difference between prophase I and prophase II is the genetic recombination process that occurs during prophase I, but does not repeat in prophase II.
In prophase II of meiosis, the following events occur: 1  The nuclear membrane and nuclei break up while the spindle network appears.â. 2  Chromosomes do not replicate any further in this phase of meiosis.â. 3  The chromosomes begin migrating to the metaphase II plate (at the cell's equator).