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A pinched sciatic nerve â or the nerve that originates in the lower part of your spine and runs the length of your leg â is the condition that arises when pressure is applied to this nerve. The sciatic nerve is the longest and thickest nerve in your body, so sciatic symptoms can be severe and debilitating.
Pinched median nerve. A pinched nerve occurs when too much pressure is applied to a nerve by surrounding tissues, such as bones, cartilage, muscles or tendons. This pressure disrupts the nerve's function, causing pain, tingling, numbness or weakness.