manifest. 1  readily perceived by the eye or the understanding; evident; obvious; apparent; plain: a manifest error. 2  Psychoanalysis. of or relating to conscious feelings, ideas, and impulses that contain repressed psychic material: the manifest content of a dream as opposed to the latent content that it conceals.
In medicine, an adverse effect is an undesired harmful effect resulting from a medication or other intervention such as surgery. An adverse effect may be termed a  side effect , when judged to be secondary to a main or therapeutic effect.
Common Side Effects. Side effects are often experienced by patients taking ADHD medications. Adverse reactions occur for a number of reasons and vary according to the type of medication prescribed, the patientâs unique genetic makeup, as well as interactions with other medications that the patient is taking.