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As a general rule, antibiotics do not cause a decrease of white blood cells (WBCs). WBCs are one of the main ways the body fights infection. Because your son had a recent illness the WBC count most likely increased during that period in order to fight his infection.
Chemotherapy helps fight cancer, but one of the side effects can be infection. Infection occursbecause anticancer drugs can also affect normal cells, including cells that produce WBCs. If neutrophils (WBCs) decrease in your body, you are at an increased risk for developing an infection.