Sphere of influence. In the field of international relations, a sphere of influence (SOI) is a spatial region or concept division over which a state or organization has a level of cultural, economic, military, or political exclusivity, accommodating to the interests of powers outside the borders of the state that controls it.
Multiple myeloma is named for the clock face appearance of these cancer cells when seen under a microscope. They infiltrate virtually all of a patient's bone marrow. In x-ray images of multiple myeloma, it looks like holes have been punched out of the bone.
Signs and symptoms of multiple myeloma can vary and, early in the disease, there may be none. When signs and symptoms do occur, they can include: 1  Bone pain, especially in your spine or chest. 2  Nausea. 3  Constipation. 4  Loss of appetite. 5  Mental fogginess or confusion. 6  Fatigue. 7  Frequent infections.