manifest. 1  readily perceived by the eye or the understanding; evident; obvious; apparent; plain: a manifest error. 2  Psychoanalysis. of or relating to conscious feelings, ideas, and impulses that contain repressed psychic material: the manifest content of a dream as opposed to the latent content that it conceals.
In medicine, an adverse effect is an undesired harmful effect resulting from a medication or other intervention such as surgery. An adverse effect may be termed a  side effect , when judged to be secondary to a main or therapeutic effect.
Adverse Drug Reactions. The World Health Organization defines an adverse drug reaction (ADR) as any noxious, unintentional, and undesired effect of a drug, which occurs at doses used in humans for prophylaxis, diagnosis, or therapy. Numerous organizations have their own definition.Any drug may cause an adverse drug reaction.Undoubtedly, all drugs produce an ADR in someone who has used them. Three to five percent (3-5%) of hospital admissions are caused by ADRs. The incidence of serious and fatal adverse reactions in hospital patients has been reported between 0.32% and 6.7%.he World Health Organization defines an adverse drug reaction (ADR) as any noxious, unintentional, and undesired effect of a drug, which occurs at doses used in humans for prophylaxis, diagnosis, or therapy. Numerous organizations have their own definition.