Hereditary neuropathies are diseases of the peripheral nerves that are genetically passed from parent to child. The most common of these is Charcot-Marie-Tooth disease type 1. It is characterized by weakness in the legs and, to a lesser degree, the arms -- symptoms that usually appear between mid-childhood and age 30.
1 Chlorine ions are colored yellow in the VRML model. 2  Sodium (Na +) and potassium (K +) are positive ions. 3  They are found on both sides of the membrane. 4  Na + ions are in greater concentration outside the neuron whereas K + ions are more concentrated inside the neuron. 5  Na + ions are colored pink in the VRML model.
Typical values of membrane potential are in the range +40 mV to â70 mV. Many ions have a concentration gradient across the membrane, including potassium (K +), which is at a high concentration inside and a low concentration outside the membrane.Sodium (Na +) and chloride (Cl â) ions are at high concentrations in the extracellular region, and low concentrations in the intracellular regions.n the simplest case, illustrated here, if the membrane is selectively permeable to potassium, these positively charged ions can diffuse down the concentration gradient to the outside of the cell, leaving behind uncompensated negative charges. This separation of charges is what causes the membrane potential.