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ESBL stands for Extended-Spectrum beta-Lactamase. Beta lactamases are enzymes that are produced by many types of bacteria (germs) which make them more resistant to antibiotics and can make the infection harder to treat.
Beta-lactamase. 1  Core structure of penicillins (top) and cephalosporins (bottom). 2  Escherichia coli bacteria on the right are sensitive to two beta-lactam antibiotics, and do not grow in the semi-circular regions surrounding the antibiotics.