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Canker sores may also occur because of certain conditions and diseases, such as: 1  Celiac disease, a serious intestinal disorder caused by a sensitivity to gluten, a protein found in most grains. 2  Inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis.
Canker sores are typically red sores or bumps that develop into a slightly concave ulcer with a whitish coating, surrounded by a red halo. Most often these are no bigger than a third of an inch in diameter and start turning grayish in color before disappearing.