manifest. 1  readily perceived by the eye or the understanding; evident; obvious; apparent; plain: a manifest error. 2  Psychoanalysis. of or relating to conscious feelings, ideas, and impulses that contain repressed psychic material: the manifest content of a dream as opposed to the latent content that it conceals.
In medicine, an adverse effect is an undesired harmful effect resulting from a medication or other intervention such as surgery. An adverse effect may be termed a  side effect , when judged to be secondary to a main or therapeutic effect.
Side effects The drug label contains warnings with regard to increased risks of severe immune-mediated inflammation of the lungs, the colon, the liver, the kidneys (with accompanying kidney dysfunction), as well as immune-mediated hypothyroidism and hyperthyroidism.