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Hi team, I have had terrible heart palpitations since starting mirtazapine, mainly towards the end of the day and when I am in bed. It's so frightening I don't know what to do, it's like my heart stops and makes me take a massive breath. I have recently increased to 30mg any ideas.i team, I have had terrible heart palpitations since starting mirtazapine, mainly towards the end of the day and when I am in bed. It's so frightening I don't know what to do, it's like my heart stops and makes me take a massive breath. I have recently increased to 30mg any ideas.
Mirtazapine is an antidepressant medication that works in the brain. It is approved for the treatment of major depressive disorder (MDD). Symptoms of depression include: 1  Depressed mood-feeling sad, empty, or tearful.2  Feeling worthless, guilty, hopeless, and helpless. 3  Loss of interest or pleasure in your usual activities.irtazapine is usually taken 1 time per day at bedtime with or without food. Typically patients begin at a low dose of medicine and the dose is increased slowly over several weeks. The dose usually ranges from 15 mg to 45 mg. Only your healthcare provider can determine the correct dose for you.