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The major difference between prophase I and prophase II is the genetic recombination process that occurs during prophase I, but does not repeat in prophase II. During prophase I, the duplicated... The major difference between prophase I and prophase II is the genetic recombination process that occurs during prophase I, but does not repeat in prophase II.
In prophase of mitosis the sister chromatids prepare to be separated into two daughter cells. Mitosis creates two daughter cells that each contain the same number of chromosomâ¦es as the parent cell. (2n) In prophase I of meiosis, the homologous chromosomes prepare to be separated. Meiosis I produces two daughter cells with 1/2 the number of chromosomes of the parent cell. Prophase II of meiosis is very similar to prophase of mitosis. In prophase II, the sister chromatids prepare to separate.