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As a general rule, antibiotics do not cause a decrease of white blood cells (WBCs). WBCs are one of the main ways the body fights infection. Because your son had a recent illness the WBC count most likely increased during that period in order to fight his infection.
Antibiotics that are resistant to the B- Lactamase enzyme, and thus can kill bacteria that the other penams cannot, include oxicillin, flucloxicillin, and methicillin; however, only two years after methicillin hit the market, strains of Staphylococcus aureus began exhibiting signs of resistance to it.