Sphere of influence. In the field of international relations, a sphere of influence (SOI) is a spatial region or concept division over which a state or organization has a level of cultural, economic, military, or political exclusivity, accommodating to the interests of powers outside the borders of the state that controls it.
Multiple myeloma is named for the clock face appearance of these cancer cells when seen under a microscope. They infiltrate virtually all of a patient's bone marrow. In x-ray images of multiple myeloma, it looks like holes have been punched out of the bone.
Signs and symptoms of multiple myeloma can vary and may include: 1  Bone pain, especially in the spine or chest. 2  Nausea, constipation, loss of appetite, weight loss. 3  Mental fogginess, confusion, fatigue.  Frequent infections and 1  fevers. Weakness or numbness in the legs.  Excessive thirst, frequent urination.