1 Examples are morphine and heroin. 2  Worldwide, an estimated 69 000 people die from opioid overdose each year.  There are an estimated 15 million people who suffer from opioid dependence (i.e. an addiction to opioids).
Berberine is a natural alkaloid found in a wide variety of traditional herbs including goldenseal, barberry and Oregon grape. Many herbalists credit this unique alkaloid for the benefits of ancient herbal tonics used by native populations throughout the world.
Berberine has also been shown to increase the production of catalase, as several international studies, including two conducted in 2006 and 2010, demonstrate. When taken in supplements, berberine can increase the production of catalase in the bodyâs mitochondria. Catalase is a crucial enzyme and super-antioxidant.Increasing its production has been shown to reduce mitochondrial dysfunction to promote anti-aging.hen taken in supplements, berberine can increase the production of catalase in the bodyâs mitochondria. Catalase is a crucial enzyme and super-antioxidant. Increasing its production has been shown to reduce mitochondrial dysfunction to promote anti-aging.