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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
Italian sailor and explorer John Cabot was born Giovanni Caboto around 1450. In 1497, Cabot traveled by sea to Canada, where he made a claim to land for England, mistaking the North American land for Asia. Cabot was the son of a spice merchant, Giulio Caboto, in Genoa. At age 11, his family moved to Venice, where he learned sailing and navigation from Italian seamen and merchants.