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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
More on this story. 1  DNA confirms ancient Asian origin for American dogs. 2  Dog evolved 'on the waste dump'. 3  Science explains the wrinkly dog. 4  Domestic dog origins challenged. 5  Dog gene 'may aid wolf survival'.