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Melanosis coli is a condition usually associated with chronic laxative use in which dark pigment is deposited in the lamina propria (one of the lining layers) of the large intestine (colon). The pigment deposition results in a characteristic dark brown to black discoloration of the lining of the large intestine.
Collagenous colitis is a type of inflammatory bowel disease of the colon. On sigmoidoscopy or colonoscopy the bowel lining appears to be normal but microscopic examination of biopsies shows inflammation.The cause is unclear. The primary symptom of collagenous colitis is a non-bloody, watery diarrhea, but there also may be abdominal pain.The usual tests for diagnosing the cause of diarrhea are normal, and the diagnosis is made with the microscopic exam of colonic biopsies.he primary symptom of collagenous colitis is a non-bloody, watery diarrhea, but there also may be abdominal pain. The usual tests for diagnosing the cause of diarrhea are normal, and the diagnosis is made with the microscopic exam of colonic biopsies.