Chardonnay is an important component of many sparkling wines around the world, including Champagne. A peak in popularity in the late 1980s gave way to a backlash among those wine connoisseur who saw the grape as a leading negative component of the globalization of wine.oday, the Chardonnay made in the Chablis region is one of the purest expression of the varietal character of the grape due to the simplistic style of winemaking favored in this region. Chablis winemakers want to emphasise the terroir of the calcareous soil and cooler climate that help maintain high acidity.
Vanishing White Matter Disease. Vanishing white matter (VWM) disease is an inherited condition caused by a faulty gene. Children with VWM disease have a defective protein that prevents the body from making enough myelin, a white, fatty substance that insulates nerve fibers, protecting them from damage. Nerve fibers covered by myelin are known as âwhite matter.â Without myelin, nerves throughout the body deteriorate and disappear. Symptoms, such as muscle stiffness and poor bodily coordination, often begin to appear between ages 2 and 6.
Krabbe disease is a rare, inherited degenerative disorder of the central and peripheral nervous systems. It is characterized by the presence of globoid cells (cells that have more than one nucleus), the breakdown of the nerveâs protective myelin coating, and destruction of brain cells.Krabbe disease is one of a group of genetic disorders called the leukodystrophies.These disorders impair the growth or development of the myelin sheath, the fatty covering that acts as an insulator around nerve fibers, and cause severe deterioration of mental and motor skills.t is characterized by the presence of globoid cells (cells that have more than one nucleus), the breakdown of the nerveâs protective myelin coating, and destruction of brain cells. Krabbe disease is one of a group of genetic disorders called the leukodystrophies.