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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
Giovanni Caboto (known in English as John Cabot; c. 1450 - c. 1499) was an Italian navigator and explorer whose 1497 discovery of North A â¦ merica is commonly held to be the first European voyage to the continent since Norse exploration of the Americas in the early eleventh century.