1 To establish the maximum tolerable dose of betahistine dihydrochloride (betahistine) within the range of 50 mg to 300 mg/day that appears to be effective for atypical depression. Are at significant risk of suicide as indicated by a score of 3 or greater on item number 11 on the HAM-D 28. 2  Have received any investigational product within 28 days of Screening. 3  Have used any antidepressant within 7 days of Screening (14 days for MAOIs; 21 days for fluoxetine).
Boulder Creek, California. Boulder Creek is a census-designated place (CDP) in Santa Cruz County, California, with a population of 4,923 as of the 2010 census.
Cave Creek is a town in the Sonoran Desert. According to the United States Census Bureau, the town has a total area of 28.2 square miles (73 km 2), all land. It is adjacent to the town of Carefree, and shares local landmark Black Mountain with Carefree. There are two notable streams known as Cave Creek in Arizona. One flows through the Town of Cave Creek and into Phoenix. This may be the origin of the Town's name. The other Cave Creek (Cave Creek Canyon) is in the Chiricahua Mountains, 200 miles to the southeast.