Though CD4 and CD8 are capable of binding to MHC molecules in the absence of the T cell receptor (TCR), increasing evidence suggests that they may primarily function by complexing with the TCR to form a 'co-receptor' for recognition of antigen-bound MHC.D4 and CD8 T cell surface molecules play a role in T cell recognition and activation by binding to their respective class II and class I major histocompatibility complex (MHC) ligands on an antigen presenting cell (APC).
Chicken Boil Basics. Large chicken legs should be boiled for 35 to 40 minutes before checking if they're cooked through. Chicken legs vary in size greatly and you should always base chicken's doneness on checking either the internal temperature of a leg using a kitchen thermometer or ensuring that its juices run clear. Chicken will register at 165 degrees Fahrenheit at the thickest point when cooked.
Preheat a gas or charcoal grill to 400 degrees F. If you are using a charcoal grill without a temperature gauge, this will take about 20 minutes. Brush the grates of the grill lightly with vegetable oil to prevent sticking.he Best Way to Cook Drumsticks on the Grill. Brush chicken drumsticks with barbecue sauce before grilling them for extra flavor. Photo Credit amenic181/iStock/Getty Images. Chicken drumsticks are flavorful, fairly fatty cuts that stand up well to grilling, and remain moist when cooked over high heat.