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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
Early Life. John Cabot was most likely born in Italy, some time around the year 1450. In Italy, he is referred to as Giovanni Caboto. Not much is known about his early life except for the fact that he became a Venetian citizen (resident of Venice) in 1476. In the 1480s, he married a woman named Mattea and had three sons.