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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
John Cabot (Italian: Giovanni Caboto, Venetian: Zuan Chabotto; c. 1450 â c. 1500) was a Venetian navigator and explorer whose 1497 discovery of the coast of North America under the commission of Henry VII of England was the first European exploration of the mainland of North America since the Norse visits to Vinland in the eleventh century.