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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
Though the exact details of his life and expeditions are the subject of debate, John Cabot (or Giovanni Caboto, as he was known in Italian) may have developed the idea of sailing westward to reach the riches of Asia while working for a Venetian merchant.