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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
Wolves and dogs belong to the same genus (Canis), although they are different species (Canis lupus for the wolf and Canis domesticus for the dog). DNA evidence has shown that domestic dogs trace their ancestry to wolves, although some breeds are many more generations removed than others.