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Best Answer: Midol usually kicks in within 20-30 minutes, but after the Midol is gone, why don't you just stop purchasing this over-priced medicine and begin to use plain old aspirin (buffered, if you worry about stomach issues) as that is the main ingredient in Midol and Pamprin (either aspirin or active ingredients in Tylenol).
According to experts, it takes 15- 20 min for Ibuprofen to kick in and close to 2 hours to take effect. It also depends on the form of Ibuprofen, like; if you are taking ibuprofen in liquid form it will take lesser time as the body doesnât need to break down the capsule/Tablet.