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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
If you are thinking that wolf hybrids are crosses between wolves and dogs, then you certainly are on the right track. However, wolf hybrid is in actuality an antiquated term for as of 1993, dogs (Canis lupus familiaris) have been reclassified as a subspecies under wolves (Canis lupus).This is probably a good time to remind you what a hybrid is. A hybrid is the progeny of two different species (i.e. carabao and cattle).owever, wolf hybrid is in actuality an antiquated term for as of 1993, dogs (Canis lupus familiaris) have been reclassified as a subspecies under wolves (Canis lupus). This is probably a good time to remind you what a hybrid is. A hybrid is the progeny of two different species (i.e. carabao and cattle).