1 Examples are morphine and heroin. 2  Worldwide, an estimated 69 000 people die from opioid overdose each year.  There are an estimated 15 million people who suffer from opioid dependence (i.e. an addiction to opioids).
Berberine is a natural alkaloid found in a wide variety of traditional herbs including goldenseal, barberry and Oregon grape. Many herbalists credit this unique alkaloid for the benefits of ancient herbal tonics used by native populations throughout the world.
âHow to use Berberine with other Supplements to boost weight loss + results. 1  Alpha lipoic acid: ALA is a powerful anti inflammatory agent that boosts mitochondrial function, reduces insulin resistance and is incredibly powerful if used in sustained release form with doses as high as 1,800-2,400mg per day.