(IS, 4S)-4-(3, 4-dichlorophenyl)-l, .2, 3, 4- tetrahydro-N-metihyl-1-naphthalenamine, commonly known as Sertraline, is marketed in the form of its hydrochloride salt. Sertraline is used in the treatment of depression, obsessive-compulsive disorder and panic disorder.UMMARY OF THE INVENTION. The present invention discloses a novel method for the preparation of racemic sertraline starting from the known tetralone and cis(+) sertraline hydrochloride form II from cis(+) sertraline mandelate.
The mitral valve (also known as the bicuspid valve or left atrioventricular valve) is a dual-flap (bi-from the Latin, meaning double, and mitral-from the Latin, meaning shaped like a mitre) valve in the heart that lies between the left atrium (LA) and the left ventricle (LV).
In mitral valve disease, the mitral valve, which is located between your left heart chambers (left atrium and left ventricle), doesn't work properly. Types of mitral valve disease include:Mitral valve regurgitation. In this condition, the flaps (leaflets) of the mitral valve don't close tightly, causing blood to leak backward into the left atrium of your heart. If not treated, it can result in heart muscle damage.The most common cause of blood leakage is mitral valve prolapse, in which the leaflets bulge back into the left atrium as your heart contracts. 1  Mitral valve stenosis. 2  In this condition, the flaps of the mitral valve become thick or stiff, and they may fuse together.f not treated, it can result in heart muscle damage. The most common cause of blood leakage is mitral valve prolapse, in which the leaflets bulge back into the left atrium as your heart contracts. 1  Mitral valve stenosis. 2  In this condition, the flaps of the mitral valve become thick or stiff, and they may fuse together.