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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
Although wolves are often mixed with spitz types such as Siberian Huskies, Alaskan Malamutes, and German Shepherds, hybrids between wolves to non-Spitz type dogs such as Poodles, Pitbulls, and Great Pyrenees also exist, the latter hybrids often having less lupine features.ntra-hybridization between dogs and other subspecies of gray wolves are the most common wolfdogs since dogs and gray wolves are considered the same species hence are genetically very close and have shared vast portions of their ranges for millennia.