Though CD4 and CD8 are capable of binding to MHC molecules in the absence of the T cell receptor (TCR), increasing evidence suggests that they may primarily function by complexing with the TCR to form a 'co-receptor' for recognition of antigen-bound MHC.D4 and CD8 T cell surface molecules play a role in T cell recognition and activation by binding to their respective class II and class I major histocompatibility complex (MHC) ligands on an antigen presenting cell (APC).
Chicken Boil Basics. Large chicken legs should be boiled for 35 to 40 minutes before checking if they're cooked through. Chicken legs vary in size greatly and you should always base chicken's doneness on checking either the internal temperature of a leg using a kitchen thermometer or ensuring that its juices run clear. Chicken will register at 165 degrees Fahrenheit at the thickest point when cooked.
Fire up your smoker 30 minutes prior to cooking. This will allow it to come up to a temperature of 220 degrees. Mix all dry rub seasoning ingredients together in a mixing bowl and rub olive oil all over the chicken legs to fully coat the drumsticks. Rub the seasoning mix to fully coat the outside of the legs.