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A lupus flare up is a temporary worsening of the symptoms that are related to the disease. When a SLE flare is imminent, there may be certain ways to tell. Patients with lupus may notice changes in their body before the flare actually occurs. They may notice subtle changes in their symptoms, or new symptoms could occur.
The cause for lupus in most cases, however, is unknown. Some potential triggers include: 1  Sunlight. 2  Exposure to the sun may bring on lupus skin lesions or trigger an internal response in susceptible people. 3  Infections. 4  Having an infection can initiate lupus or cause a relapse in some people. 5  Medications.