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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
A female pure wolf breeds with a pure male dog--the pups will all have the wolf mtDNA of the mother. There will be a half-and-half mixing of dog and wolf nuclear DNA. The male pups will have a pure dog Y chromosome and a pure wolf X chromosome, with all genes of the latter being expressed.