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Yes. In relation to Theodore, Franklin Roosevelt was a distant cousin who later become a nephew-in-law, when he married Teddy's niece, Anna Eleanor Roosevelt. Franklin and Theodore Roosevelt were both descendants from Dutch colonists, who settled in the New York area in the mid-17th century. According to any Franklin Roosevelt biography, the two were fifth cousins, having a paternal relative in common (Nicholas Roosevelt, 1658-1742).
The most important woman was Sara Delano. (The other two were Lucy Mercer and Missy Lehand.) Franklin's mother Sara was both the great constant in his life and the most important influencein forming his character. Eleanor Roosevelt was one of the most remarkable women of the 20th century. She played an important role in President Roosevelt's political career.