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A lupus flare up is a temporary worsening of the symptoms that are related to the disease. When a SLE flare is imminent, there may be certain ways to tell. Patients with lupus may notice changes in their body before the flare actually occurs. They may notice subtle changes in their symptoms, or new symptoms could occur.
Lupus symptoms depend on what body organs are affected and how seriously they are affected. Common symptoms. Many people have these symptoms: Fatigue: Lupus causes mild to extreme fatigue. Even mild cases of lupus make it hard to do daily activities and exercise. Increased fatigue is a classic sign that a symptom flare is about to occur.