Though CD4 and CD8 are capable of binding to MHC molecules in the absence of the T cell receptor (TCR), increasing evidence suggests that they may primarily function by complexing with the TCR to form a 'co-receptor' for recognition of antigen-bound MHC.D4 and CD8 T cell surface molecules play a role in T cell recognition and activation by binding to their respective class II and class I major histocompatibility complex (MHC) ligands on an antigen presenting cell (APC).
Chicken Boil Basics. Large chicken legs should be boiled for 35 to 40 minutes before checking if they're cooked through. Chicken legs vary in size greatly and you should always base chicken's doneness on checking either the internal temperature of a leg using a kitchen thermometer or ensuring that its juices run clear. Chicken will register at 165 degrees Fahrenheit at the thickest point when cooked.
The secret of a great chicken leg (drumstick) was in the temperature as usual. Since then I have done mainly oven drummies. I kind of did this post before in my Chicken for a Hundred post. I was cooking for a party and roasted 150 chicken legs and breast in a similar manner. then seasoned my 6 chicken legs with Natures Seasoning and salt, placed them on the bed of potatoes and onion, covered it, put it in a 450 degree oven for 20 mins. then UN-covered it and baked for an additional 45 mins (I have a very small oven (on a houseboat) so it takes a bit longer to bake/cook in it).