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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
John Cabot (Giovanni Caboto) was born in Genoa, Italy, in 1450. New World Discoverer John Cabot was born in Genoa, Italy, in 1450. We believe that he was born in this very house that is now falsely called the birthplace of Columbus. Genoa, Italy, was the birthplace of Cabot. John Cabot was born in Genoa, Italy, in 1450.