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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
John Cabot is one of the greatest Italian explorers. His 1497 North American discovery was the first since the explorations of the Northern Vikings of the 11th century. Cabotâs biological name and birthplace has been the subject of debates throughout history.