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In particular, the main drugs that can lead to low potassium levels are: 1  Diuretics or 'Water Pills. ' 2 Laxatives. 3  Any drugs that cause Magnesium Depletion.
However, some diuretics can also cause you to eliminate more potassium in your urine. This can lead to low potassium levels in your blood (hypokalemia). Not all diuretics cause this problem. The potassium-sparing diuretics don't lower potassium levels.