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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
Wolf-dog phenotyping is an attempt to identify the morphological traits (the branch of biology studying the form and structure of plants and animals) and the behavioral characteristics of wolves and malamutes, german shepherds, and siberian huskiesâthe three most common dog breeds used to create wolf-dogs.