Van Pelt in Jumanji: The Animated Series. Van Pelt returns as a recurring villain in the animated series based on the movie. He is revealed to be a part of the game, and when he actually dies in an episode, Peter starts to become him little by little, but is saved by Alan and Judy.
http://www.chacha.com/question/which-episode-of-grey's-anatomy-does-izzy-get-diagnosed-with-cancer. Izzie discovers she has metastatic melanoma (Stage IV) in season 5 episode 17 I Will Follow You Into the Dark of Grey's Anatomy.
Laurie was diagnosed with the Epstein-Barr Virus. Before too long, she was exhausted constantly, no matter when she went to bed, she could not physically get herself out of bed. One day she finally went to the emergency room and found out she had a large tumor in her chest.