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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
A wolfdog (also called a wolfâdog hybrid or wolf hybrid) is a canid hybrid resulting from the hybridization of a domestic dog (Canis lupus familiaris) to one of four other Canis sub-species, the gray (Canis lupus), eastern timber (Canis lycaon), red (Canis rufus), and Ethiopian wolves (Canis simensis). 1 Description.