(IS, 4S)-4-(3, 4-dichlorophenyl)-l, .2, 3, 4- tetrahydro-N-metihyl-1-naphthalenamine, commonly known as Sertraline, is marketed in the form of its hydrochloride salt. Sertraline is used in the treatment of depression, obsessive-compulsive disorder and panic disorder.UMMARY OF THE INVENTION. The present invention discloses a novel method for the preparation of racemic sertraline starting from the known tetralone and cis(+) sertraline hydrochloride form II from cis(+) sertraline mandelate.
The mitral valve (also known as the bicuspid valve or left atrioventricular valve) is a dual-flap (bi-from the Latin, meaning double, and mitral-from the Latin, meaning shaped like a mitre) valve in the heart that lies between the left atrium (LA) and the left ventricle (LV).
The mitral valve regulates the flow of oxygen rich blood from the lungs to pass from the left atrium to the left ventricle.There are two main diseases or malfunctions of heart valves: regurgitation (valve does not close tightly) and stenosis (valve does not open fully).itral Valve Regurgitation, Stenosis, and Prolapse. The mitral valve is referred to as atrioventricular valves because it is located between the left atria and the left ventricle.