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Addisonâs disease most commonly affects female dogs around four or five years old. This condition is typically caused by injury to the adrenal glandsâ tissue from infection, hemorrhaging, or autoimmune disorders. If your pet is coming off of steroid treatment, the steroid withdrawal may also be causing an imbalance.
Addison's disease should also be distinguished from secondary and tertiary adrenal insufficiency, which are caused by deficiency of ACTH (produced by the pituitary gland) and CRH (produced by the hypothalamus), respectively.Despite this distinction, Addisonian crises can happen in all forms of adrenal insufficiency.ddison's disease is associated with the development of other autoimmune diseases, such as type I diabetes, thyroid disease (Hashimoto's thyroiditis), and vitiligo. The presence of Addison's in addition to one of these is called called autoimmune polyendocrine syndrome.