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Best Answer: Midol usually kicks in within 20-30 minutes, but after the Midol is gone, why don't you just stop purchasing this over-priced medicine and begin to use plain old aspirin (buffered, if you worry about stomach issues) as that is the main ingredient in Midol and Pamprin (either aspirin or active ingredients in Tylenol).
A. Midol is a brand name owned by Bayer. Bayer manufactuers several different over-the-counter pain relief products under the Midol name. Some Midol products contain ibuprofen, and you definitely should not take additional ibuprofen with those Midol products. You also should not take ibuprofen with any Midol product that contains naproxyn sodium or aspirin. However, you CAN take ibuprofen with Midol products that contain only acetaminophen and/or pamabrom. You should read the label of your Midol product very carefully to determine what's in it. Please consult a pharmacist for assistance.