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O. volvulus is transmitted by sandflies, and their role in the transmission of onchocerciasis was discovered by the Scottish parasitologist Breadablane Blacklock in Sierra Leone in the mid-1920s (19). There are accounts of the history of onchocerciasis by Grove (105) and Muller (192).
The term inborn error of metabolism was coined by a British physician, Archibald Garrod (1857â1936), in the early 20th century (1908).He is known for work that prefigured the one gene-one enzyme hypothesis, based on his studies on the nature and inheritance of alkaptonuria.n a study in British Columbia, the overall incidence of the inborn errors of metabolism were estimated to be 40 per 100,000 live births or 1 in 1,400 births, overall representing more than approximately 15% of single gene disorders in the population.