1 To establish the maximum tolerable dose of betahistine dihydrochloride (betahistine) within the range of 50 mg to 300 mg/day that appears to be effective for atypical depression. Are at significant risk of suicide as indicated by a score of 3 or greater on item number 11 on the HAM-D 28. 2  Have received any investigational product within 28 days of Screening. 3  Have used any antidepressant within 7 days of Screening (14 days for MAOIs; 21 days for fluoxetine).
Boulder Creek, California. Boulder Creek is a census-designated place (CDP) in Santa Cruz County, California, with a population of 4,923 as of the 2010 census.
However, the area that the river drains in Orange County downstream of Santiago Creek is extremely narrow, because of the diversion of its former Orange County drainage area to the Talbert and Huntington Beach flood control channels, which empty into the Pacific very near the mouth of the Santa Ana.ne of its largest tributaries, the San Jacinto River, rarely reaches the Santa Ana except in extremely wet years. The relative lack of vegetation also makes the river prone to flash flooding. Even so, a wide variety of animal and plant life has always been dependent on the river.