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DEFICIENCY SYMPTOMS: Symptoms and signs of lysine deficiency include: anemia, apathy, bloodshot eyes, depression, edema, fatigue, fever blisters, hair loss, inability to concentrate, infertility, irritability, lethargy, liver damage, loss of energy, muscle loss, retarded growth, stomach ulcers, and weakness.
Safety Issues. Although lysine is an essential part of the diet, the safety of concentrated lysine supplements has not been well studied. In animal studies, high dosages have caused gallstones and elevated cholesterol levels, 15,16 so you may want to use caution when using lysine if you have either of these problems.