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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
Perhaps the biggest difference between a wolf and a dog, and also the thing that causes the most problems when owning a wolf is their mental state. Dogs only develop to the mental stage of a 10 to 30 day old wolf puppy.