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The vertebral and basilar arteries supply blood to several structures in the brain including: the occipital cortex, the brainstem consisting of the midbrain, pons and medulla, the cerebellum and the thalamus. Atherosclerosis or hardening of the arteries is the primary cause of vertebrobasilar disease. The narrowing of the vertebral or basilar arteries caused by atherosclerosis creates vertebrobasilar insufficiency (VBI), or an insufficient delivery of blood flow to the posterior structures of the brain.
The aorta is the root systemic artery. It receives blood directly from the left ventricle of the heart via the aortic valve. As the aorta branches, and these arteries branch in turn, they become successively smaller in diameter, down to the arterioles. The arterioles supply capillaries, which in turn empty into venules. The very first branches off of the aorta are the coronary arteries, which supply blood to the heart muscle itself.