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A lupus flare up is a temporary worsening of the symptoms that are related to the disease. When a SLE flare is imminent, there may be certain ways to tell. Patients with lupus may notice changes in their body before the flare actually occurs. They may notice subtle changes in their symptoms, or new symptoms could occur.
1 Occasionally, discoid lupus occurs with systemic lupus.  Drug-induced lupus, which accounts for about 10% of all lupus cases, occurs as a reaction to specific kinds of medications. In kids, anti-seizure medications, thyroid medications, and acne medications can cause lupus.