1 Examples are morphine and heroin. 2  Worldwide, an estimated 69 000 people die from opioid overdose each year.  There are an estimated 15 million people who suffer from opioid dependence (i.e. an addiction to opioids).
Berberine is a natural alkaloid found in a wide variety of traditional herbs including goldenseal, barberry and Oregon grape. Many herbalists credit this unique alkaloid for the benefits of ancient herbal tonics used by native populations throughout the world.
Berberine dosing could be from 500 mg -2,000 mg a day, in divided doses. Smaller, divided doses are best to avoid stomach upset, cramping, and diarrhea. Berberine should be taken with a meal to be absorbed most effectively (due to the glucose and lipid release during eating).