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Addisonâs disease most commonly affects female dogs around four or five years old. This condition is typically caused by injury to the adrenal glandsâ tissue from infection, hemorrhaging, or autoimmune disorders. If your pet is coming off of steroid treatment, the steroid withdrawal may also be causing an imbalance.
1 Addison's disease, also called adrenal insufficiency, or hypocortisolism, occurs when the adrenal glands do not produce enough of the hormone cortisol and, in some cases, the hormone aldosterone. Addison's disease is an endocrine or hormonal disorder characterized by weight loss, muscle weakness, fatigue, low blood pressure, and sometimes darkening of the skin. 2  Most cases of Addison's disease are caused by autoimmune disorders.