1 itchiness (pruritus). 2  Pruritus is the primary symptom of cholestasis and is thought to be due to interactions of serum bile acids with opioidergic nerves. 3  In fact, the opioid antagonist naltrexone is used to treat pruritus due to cholestasis.4  jaundice. Pruritus is the primary symptom of cholestasis and is thought to be due to interactions of serum bile acids with opioidergic nerves. 2  In fact, the opioid antagonist naltrexone is used to treat pruritus due to cholestasis. 3  jaundice.
For adults, the normal dose of oral doxycycline is 200 mg on the first day of treatment. Usually you take that as two 100-mg doses, 12 hours apart. After this initial dose, people usually take a maintenance dose of 100 mg daily for seven to 10 days.
Doxycycline is a tetracycline antibiotic. It fights bacteria in the body. Doxycycline is used to treat many different bacterial infections, such as acne, urinary tract infections, intestinal infections, eye infections, gonorrhea, chlamydia, periodontitis (gum disease), and others.