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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
Wolf hybrids are a cross between a Wolf and a domestic dog. However, in 1992, scientists reclassified dogs and Wolves as the same species making the term hybrid obsolete.olf content, the number of generations removed from a pure Wolf and the type of dog used in each cross must be considered when defining a Wolfdog. Because of random genetics inherited from both the dog and the Wolf, the looks and/or behavior can vary. Contact the dog breeders below for your next family friend.