The leading modifiable risk factors worldwide are: 1  tobacco smoking, which is strongly associated with lung cancer, mouth, and throat cancer; 2  drinking alcohol, which is associated with a small increase in oral, esophageal, breast, liver and other cancers; 3  a diet low in fruit and vegetables,
Trier Tourism: Best of Trier. Trier, Germany. Trier, which lies in the Moselle wine region along the banks of the Moselle River, is the oldest city in Germany. The city is home to the University of Trier.
The nearest major cities are Darmstadt (some 22 km (14 mi) to the north), Heidelberg (some 35 km (22 mi) to the south), Worms (some 18 km (11 mi) to the west) and Mannheim (some 32 km (20 mi) to the southwest). The district seat of Heppenheim lies roughly 5 km (3 mi) to the south.