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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
Dogs and wolves are actually the same species. Their physical appearance is similar but their instincts, disposition and temperament are widely different. The gray wolf, or simply the wolf is the largest wild member of the Canidae family. The dog is the domesticated form of the gray wolf. Genetic drift studies and DNA sequencing confirm that domestic dog shares a common ancestry with the gray wolf. Eurasia and North America used to hold most of the worldâs wolf population but the numbers have begun to dwindle due to human encroachment.