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Insulin Storage and Syringe Safety. Although manufacturers recommend storing your insulin in the refrigerator, injecting cold insulin can sometimes make the injection more painful. To avoid this, many providers suggest storing the bottle of insulin you are using at room temperature. Insulin kept at room temperature will last approximately 1 month.
The package insert that comes with your insulin specifies how long it remains good once it is opened, or you can ask your local pharmacist. If the insulin is unopened, it must be kept refrigerated and is good until the expiration date on the vial or pen. The problem with using opened insulin beyond the guidelines listed on the package is that the insulin can lose its potency and not work as well to lower blood glucose levels.