1 To establish the maximum tolerable dose of betahistine dihydrochloride (betahistine) within the range of 50 mg to 300 mg/day that appears to be effective for atypical depression. Are at significant risk of suicide as indicated by a score of 3 or greater on item number 11 on the HAM-D 28. 2  Have received any investigational product within 28 days of Screening. 3  Have used any antidepressant within 7 days of Screening (14 days for MAOIs; 21 days for fluoxetine).
Boulder Creek, California. Boulder Creek is a census-designated place (CDP) in Santa Cruz County, California, with a population of 4,923 as of the 2010 census.
Rock Creek is a free-flowing tributary of the Potomac River, which empties into the Atlantic Ocean via the Chesapeake Bay. The creek is 32.6 miles (52.5 km) long, with a drainage area of about 76.5 square miles (198 km2). The last quarter-mile (400 m) of the creek is affected by tides. 1 Geography.