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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
Almost any dog can breed with almost any other dog. In theory, a Chihuahua male and a Great Dane female could breed. In fact, most dogs can also successfully breed with wolves â¦ and coyotes.Since dogs and wolves are the same species, their genes are usually compatible. The physical differences between breeds have only existed for a millennium or two-a blink of the eye in DNA time.he Alaskan Husky is recently created breed of sled dog that has shown extreme aptitude. Reportedly a cross between SH and greyhounds, these are smaller dogs with greater endurance capability. Many Molosser breeds are capable of drafting, but few are as adept as the aforementioned spitz breeds.