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Mutations are physical changes in genes and chromosomes. They may be confined to a single cell or may be transmitted from one cell to another within a multicellular organism (somatic cell mutation), or may be transmitted from one generation to another through mutation in the gametes (germ-line mutation).
There are many kinds of mutations. A point mutation is a mutation in which one letter of the genetic code is changed to another. Lengths of DNA can also be deleted or inserted in a gene; these are also mutations. Finally, genes or parts of genes can become inverted or duplicated.