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Best Answer: Midol usually kicks in within 20-30 minutes, but after the Midol is gone, why don't you just stop purchasing this over-priced medicine and begin to use plain old aspirin (buffered, if you worry about stomach issues) as that is the main ingredient in Midol and Pamprin (either aspirin or active ingredients in Tylenol).
Midol is a combination, over-the-counter (OTC) drug used to relieve menstrual symptoms, including cramps and bloating.Combination OTC drugs for menstrual symptoms generally include both a pain reliever and a diuretic -- a medication that relieves bloating by causing your body to release excess fluids.Midol contains acetaminophen as a pain reliever and caffeine as a diuretic.Midol is a brand name medication, though generic equivalents are available as well.ombination OTC drugs for menstrual symptoms generally include both a pain reliever and a diuretic -- a medication that relieves bloating by causing your body to release excess fluids.