From Wikipedia: Tetralogy of Fallot (TOF) is a congenital heart defect which is classically understood to involve four anatomical abnormalities (although only three of them are always present). It is the most common cyanotic heart defect, representing 55-70%, and the most common cause of blue baby syndrome..
Variola (the virus that causes smallpox) is a member of the orthopoxvirus genus, which also includes viruses that cause cowpox, monkeypox, orf, and molluscum contagiosum. Poxviruses are the largest animal viruses, visible with a light microscope.They are larger than some bacteria and contain double-stranded DNA. Poxviruses are the only viruses that do not need a cell's nucleus to replicate inside the cell. The variola virus is the only known cause of smallpox.The disease affects only humans.oxviruses are the only viruses that do not need a cell's nucleus to replicate inside the cell. The variola virus is the only known cause of smallpox. The disease affects only humans.
Variola virus, the causative agent of smallpox, encodes approximately 200 proteins. Over 80 of these proteins are located in the terminal regions of the genome, where proteins associated with host immune evasion are encoded.he second variola protein is the variola virus high-affinity secreted chemokine-binding protein type II (CKBP-II, CBP-II, vCCI), which binds CC-chemokine receptors.