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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
There is point-two-percent difference between the DNA of a domestic dog, and the DNA of a grey wolf. The difference between a coyote and domestic dog is higher, at four per cent. Domestic dogs are said to originate from wolf cubs that were used as guards by humans over 40,000 years ago in southeast Asia.Since that time wolves have been domesticated and used have been used by humans for hunting and herding.There are around 400 modern breeds of domesticated dogs.ogs are seen as loving creatures, whereas their wolf cousins are considered wild and ferocious. A study from Massachusetts has discovered this may be due to their early stages of development. Evolutionary biologist Dr Kathryn Lord studied how seven wolf pups and 43 dogs reacted to smells, sounds and visual stimuli.