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Acetyl coenzyme A or acetyl-CoA is an important molecule in metabolism, used in many biochemical reactions.Its main function is to convey the carbon atoms within the acetyl group to the citric acid cycle (Krebs cycle) to be oxidized for energy production.he oxidative conversion of pyruvate into acetyl-CoA is referred to as the pyruvate dehydrogenase reaction. It is catalyzed by the pyruvate dehydrogenase complex. Other conversions between pyruvate and acetyl-CoA are possible.
AMP-Activated Kinase catalyzes phosphorylation of Acetyl-CoA Carboxylase causing inhibition of the ATP-utilizing production of malonyl-CoA. Fatty acid synthesis is diminished by lack of the substrate malonyl-CoA.egulation of Acetyl-CoA Carboxylase by local metabolites: 1  Palmitoyl-CoA, the product of Fatty Acid Synthase, promotes the inactive conformation of Acetyl-CoA Carboxylase (diagram above), diminishing production of malonyl-CoA, the precursor of fatty acid synthesis. 2  This is an example of feedback inhibition.