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Yes. In relation to Theodore, Franklin Roosevelt was a distant cousin who later become a nephew-in-law, when he married Teddy's niece, Anna Eleanor Roosevelt. Franklin and Theodore Roosevelt were both descendants from Dutch colonists, who settled in the New York area in the mid-17th century. According to any Franklin Roosevelt biography, the two were fifth cousins, having a paternal relative in common (Nicholas Roosevelt, 1658-1742).
The niece of President Theodore Roosevelt (1858-1919), Eleanor was born into a wealthy New York family. She married Franklin Roosevelt, her fifth cousin once removed, in 1905. By the 1920s, Roosevelt, who raised five children, was involved in Democratic Party politics and numerous social reform organizations.