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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
You should also be aware that some people sell 'wolfdogs' that have no wolf content-some husky/malamute crosses look very wolf-ish, for example. There isn't a genetic test available [except in some specialist labs] because wolves and dogs share so much dna.o I was searching craigslist for huskies-as I do almost everyday-and I came across an ad for high content wolf-husky hybrids. Saw the picture.