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In particular, the main drugs that can lead to low potassium levels are: 1  Diuretics or 'Water Pills. ' 2 Laxatives. 3  Any drugs that cause Magnesium Depletion.
1 Low potassium in the body is called hypokalemia. 2  Symptoms include muscle cramps, weakness and irregular heartbeat, according to the University of Maryland Medical Center. 3  High potassium, called hyperkalemia, causes similar symptoms. 4  Your potassium levels may be off without these extreme symptoms, however.