The leading modifiable risk factors worldwide are: 1  tobacco smoking, which is strongly associated with lung cancer, mouth, and throat cancer; 2  drinking alcohol, which is associated with a small increase in oral, esophageal, breast, liver and other cancers; 3  a diet low in fruit and vegetables,
Trier Tourism: Best of Trier. Trier, Germany. Trier, which lies in the Moselle wine region along the banks of the Moselle River, is the oldest city in Germany. The city is home to the University of Trier.
For over 1,000 years the city's skyline has been dominated by one building, Mainz Cathedral. Towering majestically in its central location, the cathedral is one of the most important churches in Germany. Its foundation stone was laid in 975 AD under the aegis of Bishop Willigis.