(IS, 4S)-4-(3, 4-dichlorophenyl)-l, .2, 3, 4- tetrahydro-N-metihyl-1-naphthalenamine, commonly known as Sertraline, is marketed in the form of its hydrochloride salt. Sertraline is used in the treatment of depression, obsessive-compulsive disorder and panic disorder.UMMARY OF THE INVENTION. The present invention discloses a novel method for the preparation of racemic sertraline starting from the known tetralone and cis(+) sertraline hydrochloride form II from cis(+) sertraline mandelate.
The mitral valve (also known as the bicuspid valve or left atrioventricular valve) is a dual-flap (bi-from the Latin, meaning double, and mitral-from the Latin, meaning shaped like a mitre) valve in the heart that lies between the left atrium (LA) and the left ventricle (LV).
Mitral valve regurgitation means that one of the valves in your heart-the mitral valve-is letting blood leak backward into the heart.Heart valves work like one-way gates, helping blood flow in one direction between heart chambers or in and out of the heart. The mitral valve is on the left side of your heart.It lets blood flow from the upper to the lower heart chamber. See a picture of mitral valve regurgitation.When the mitral valve is damaged-for example, by an infection-it may no longer close tightly.This lets blood leak backward, or regurgitate, into the upper chamber.t lets blood flow from the upper to the lower heart chamber. See a picture of mitral valve regurgitation. When the mitral valve is damaged-for example, by an infection-it may no longer close tightly. This lets blood leak backward, or regurgitate, into the upper chamber.