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Melanosis coli is a condition usually associated with chronic laxative use in which dark pigment is deposited in the lamina propria (one of the lining layers) of the large intestine (colon). The pigment deposition results in a characteristic dark brown to black discoloration of the lining of the large intestine.
Microscopic colitis, which includes collagenous colitis and lymphocytic colitis, is characterized by chronic diarrhea caused by inflammation in the colon.It is not related to ulcerative colitis or to Crohn's disease, which are more severe forms of inflammatory bowel disease.There is also no evidence to suggest that microscopic colitis carries the same increased risk for colon cancer as ulcerative colitis.t is not related to ulcerative colitis or to Crohn's disease, which are more severe forms of inflammatory bowel disease. There is also no evidence to suggest that microscopic colitis carries the same increased risk for colon cancer as ulcerative colitis.