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In particular, the main drugs that can lead to low potassium levels are: 1  Diuretics or 'Water Pills. ' 2 Laxatives. 3  Any drugs that cause Magnesium Depletion.
People who are most likely to have low potassium levels include: Those who take diuretics in order to treat high blood pressure or heart disease. Anyone who frequently takes laxatives. Anyone who has recently had an illness that caused vomiting and diarrhea.