Chardonnay is an important component of many sparkling wines around the world, including Champagne. A peak in popularity in the late 1980s gave way to a backlash among those wine connoisseur who saw the grape as a leading negative component of the globalization of wine.oday, the Chardonnay made in the Chablis region is one of the purest expression of the varietal character of the grape due to the simplistic style of winemaking favored in this region. Chablis winemakers want to emphasise the terroir of the calcareous soil and cooler climate that help maintain high acidity.
Vanishing White Matter Disease. Vanishing white matter (VWM) disease is an inherited condition caused by a faulty gene. Children with VWM disease have a defective protein that prevents the body from making enough myelin, a white, fatty substance that insulates nerve fibers, protecting them from damage. Nerve fibers covered by myelin are known as âwhite matter.â Without myelin, nerves throughout the body deteriorate and disappear. Symptoms, such as muscle stiffness and poor bodily coordination, often begin to appear between ages 2 and 6.
There are two things that made the Dobe vWD appear to be inherited in a fashion like the human disease. (1) The Dobe mutation is what geneticists refer to as leaky.. That is, the mutant gene makes a small amount of normal vWF protein. The amount made by each mutant gene is about 5% of the total normal amount.here are two things that made the Dobe vWD appear to be inherited in a fashion like the human disease. (1) The Dobe mutation is what geneticists refer to as leaky.. That is, the mutant gene makes a small amount of normal vWF protein. The amount made by each mutant gene is about 5% of the total normal amount.