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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
Intra-hybridization between dogs and other subspecies of gray wolves are the most common wolfdogs since dogs and gray wolves are considered the same species hence are genetically very close and have shared vast portions of their ranges for millennia.ne of the issues that many researchers and wolfdog communities are faced with is identifying wolfdogs from pure dogs and any of the wolf species mixed into the hybrid. The most common method used by various wolfdog communities is phenotyping, a method that involves observing the animal's physical features.