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Best Answer: There is only a .2% change in the DNA of all breeds and that change is all in appearance... Anyway, the three breeds that are the closest to a wolf have to be a German Shepherd, Husky, and an Alaskan Malamute... Source(s): Capt. Jack Sparrow Â· 6 years ago.
Technically, Cindy is correct. All dog breeds are still placed in the same species Canis lupus familiaris, which means they are a subspecies of wolf. That's right, wolves and dogs are the same species. There are currently 36 species of wild dog. Then there is the domestic dog with dozens of breeds. However, the terminology may be outdated and incorrect. This paper says that dogs, genetically, are now 4 clades.