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Addisonâs disease most commonly affects female dogs around four or five years old. This condition is typically caused by injury to the adrenal glandsâ tissue from infection, hemorrhaging, or autoimmune disorders. If your pet is coming off of steroid treatment, the steroid withdrawal may also be causing an imbalance.
Possible Causes of Cushings Disease in Dogs. Spontaneous Cushings disease in dogs can be caused by one of the following: 1  Tumors of Pituitary Gland: This is the most common cause of spontaneous Cushing's disease. 2  Up to around 85% of all cases of spontaneous Cushing's disease in dogs are caused by pituitary gland tumors. The tumor cells cause the pituitary gland to over produce ACTH. 2  This results in the over-production of corticosteroids by the adrenal glands. 3  Tumors of Adrenal Glands: The remaining cases of spontaneous Cushing's disease are caused by a tumor in either one, or in rare cases, both of the adrenal glands.