1 To establish the maximum tolerable dose of betahistine dihydrochloride (betahistine) within the range of 50 mg to 300 mg/day that appears to be effective for atypical depression. Are at significant risk of suicide as indicated by a score of 3 or greater on item number 11 on the HAM-D 28. 2  Have received any investigational product within 28 days of Screening. 3  Have used any antidepressant within 7 days of Screening (14 days for MAOIs; 21 days for fluoxetine).
Boulder Creek, California. Boulder Creek is a census-designated place (CDP) in Santa Cruz County, California, with a population of 4,923 as of the 2010 census.
The origins of the South, Middle and North Forks of Willow Creek are derived from springs and seasonal runoff from Bangtail Ridge, and these three merge to form Willow Creek, which runs through the ranch.