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In particular, the main drugs that can lead to low potassium levels are: 1  Diuretics or 'Water Pills. ' 2 Laxatives. 3  Any drugs that cause Magnesium Depletion.
How Does It Work? Amiloride is a diuretic, which is commonly referred to as a water pill.. While most diuretics can cause low potassium levels in the blood (hypokalemia), amiloride is a potassium-sparing diuretic, meaning that it can actually increase potassium levels in the blood.