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Best Answer: Midol usually kicks in within 20-30 minutes, but after the Midol is gone, why don't you just stop purchasing this over-priced medicine and begin to use plain old aspirin (buffered, if you worry about stomach issues) as that is the main ingredient in Midol and Pamprin (either aspirin or active ingredients in Tylenol).
As a guide the drops take between 15-30 minutes to kick in and the effects of which will last between 3-8 hours. The exact time will depend on the strength of drop used and the colour of your eyes. Darker coloured eyes take tend to recover faster. I hope that helps.