Definition of sociopolitical. : of, relating to, or involving a combination of social and political factors.
Beta-1 receptors are found in the heart, and when stimulated will increase herat rate and cardiac contractility. Beta-2 receptors are found on vascular smooth muscle located in the heart and skeletal muscle, and when they are activated, they dilate and decrease SVR.
Adrenergic receptors can be desensitized and downregulated in certain conditions, such as in chronic heart failure (HF).4 Finally, the relative binding affinities of individual inotropes and vasopressors to adrenergic receptors can be altered by hypoxia5 or acidosis,6 which mutes their clinical effect.