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It is named after John Langdon Down, the British doctor who fully described the syndrome in 1866. Some aspects of the condition were described earlier by Jean-Ãtienne Dominique Esquirol in 1838 and Ãdouard SÃ©guin in 1844. In 1957, the genetic cause of Down syndrome, an extra copy of chromosome 21, was discovered.
John Paul Jones continued his patrol of the New England coast until July of 1777 when he took charge of the newly-built Ranger. Named in honor of American riflemen, the Ranger was a specially constructed warship and not a converted merchant vessel. On November 1, 1777, the Ranger set sail for France.