Another related concept is that neoadjuvant therapy acts on micrometastatic disease. The downstaging is then a surrogate marker of efficacy on undetected dissemination, resulting in improved longtime survival compared to the surgery-alone strategy.
Mexican-American Cesar Chavez (1927-1993) was a prominent union leader and labor organizer. Hardened by his early experience as a migrant worker, Chavez founded the National Farm Workers Association in 1962. His union joined with the Agricultural Workers Organizing Committee in its first strike against grape growers in California, and the two organizations later merged to become the United Farm Workers.
And yet, Chavez maintained a stance of nonviolence throughout the 1960s, even going on hunger strikes in hopes of quelling the violence â at least until 1970, when he made this statement that suggested a more nuanced take: