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If an autoimmune disease destroys the body's platelets, thrombocytopenia can occur. One example of this type of autoimmune disease is immune thrombocytopenia (ITP). ITP is a bleeding disorder in which the blood doesn't clot as it should.
Physiology: Antiplatelet agents and bleeding risk. 1  Plavix, Aspirin poison platelets for full 21 day life. 2  Agents stopped 7 days before surgery allows 33% of platelets to regenerate (50,000) 3  Adequate platelet aggregation returns within 5 days of stopping antiplatelet agents.