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The Five Spanish Missions of Old San Antonio A chain of five missions established along the San Antonio River in the 18th century became the largest concentration of Catholic missions in North America.ission San Francisco de la Espada, like its sister missions San Jose, San Juan, and Concepcion, had its beginnings in East Texas. Originally named San Francisco de los Tejas, Espada was renamed and relocated to San Antonio in 1731. It is the southernmost of the chain of missions located on the San Antonio River.
The first mission in Texas was established in 1632 near present-day San Angelo. It was a follow-up effort to an initial 1629 missionary trip to the area at the request of the Jumano Indians, which was the first journey into Texas specifically for Christian evangelization.