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If an autoimmune disease destroys the body's platelets, thrombocytopenia can occur. One example of this type of autoimmune disease is immune thrombocytopenia (ITP). ITP is a bleeding disorder in which the blood doesn't clot as it should.
The plug is prevented from spreading away from the site of injury by the production of prostacyclin I 2 (PGI 2), which is a potent inhibitor of platelet aggregation and release, in the normal endothelium in adjacent areas.ormation of platelets involves âpinching offâ bits of cytoplasm from the megakaryocyte, with each megakaryocyte giving rise to about 1000 platelets. The normal platelet count in blood is about 300 Ã 10 9 /litre. The structure of platelets is complex.