12/30/2016. Where We Are. The Savannah River Site (SRS), a 310 square mile (198,046 acres) Department of Energy site, is located in the sand-hills region of South Carolina. It encompasses parts of Aiken, Barnwell and Allendale counties and is bordered on the west by the Savannah River and Georgia.
The NOD2 gene provides instructions for making a protein that plays an important role in immune system function. The NOD2 protein is active in some types of immune system cells (including monocytes, macrophages, and dendritic cells), which help protect the body against foreign invaders such as viruses and bacteria.rohn disease-increased risk from variations of the NOD2 gene. Approximately 40 variations in the NOD2 gene have been associated with an increased risk of Crohn disease, a complex disorder of the digestive system.
Specifically, CD patients who carry NOD2 mutations are more likely to require small bowel surgery, and there is evidence of a gene-dose effect: NOD2 homozygotes, on average, require surgery sooner than do heterozygotes, who, in turn, require surgery earlier than do wild-type homozygotes.OD2 mutations are associated with small bowel CD and, in some studies, with stricturing disease. This anatomical association negates the use of NOD2 in distinguishing CD from ulcerative colitis, as further diagnostic tests are not needed to distinguish small bowel from colonic inflammation.