Another related concept is that neoadjuvant therapy acts on micrometastatic disease. The downstaging is then a surrogate marker of efficacy on undetected dissemination, resulting in improved longtime survival compared to the surgery-alone strategy.
Mexican-American Cesar Chavez (1927-1993) was a prominent union leader and labor organizer. Hardened by his early experience as a migrant worker, Chavez founded the National Farm Workers Association in 1962. His union joined with the Agricultural Workers Organizing Committee in its first strike against grape growers in California, and the two organizations later merged to become the United Farm Workers.
In 1948, Chavez married another farm worker and began a family. By the end of the 1950s, Chavez and his wife had eight children. He continued as a farm worker, but decided to try to organize the workers into a union to get better conditions and wages. Neither California nor federal labor laws protected farm workers.