Terms. 1  mesencephalon A part of the brain located rostral to the pons and caudal to the thalamus and the basal ganglia, composed of the tectum (dorsal portion) and the tegmentum (ventral portion). 2  substantia nigra Brain structure located in the midbrain that plays an important role in reward and movement.
De novo review refers to the appellate court's authority to review the trial court's conclusions on questions of the application, interpretation, and construction of law. Generally, the proper standard of review for employee benefit decisions, such as the denial of benefit claims, is de novo.
De novo mutation, an alteration in a gene that is present for the first time in one family member as a result of a mutation in a germ cell (egg or sperm) of one of the parents or in the fertilized egg itself. De novo transcriptome assembly, the method of creating a transcriptome without a reference genome.