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If an autoimmune disease destroys the body's platelets, thrombocytopenia can occur. One example of this type of autoimmune disease is immune thrombocytopenia (ITP). ITP is a bleeding disorder in which the blood doesn't clot as it should.
Many medications can cause low platelet count by causing immunologic reaction against platelets, called drug-induced thrombocytopenia. Some examples may include: 1  sulfonamide antibiotics, 2  carbamazepine [(Tegretol, Tegretol XR, Equetro, Carbatrol) anti-seizure drug], 3  digoxin (Lanoxin),