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An afferent pupillary defect is an eye condition where one eye is less sensitive to light, and will not contract as sharply in response to light as the unaffected eye.This can be a sign of optic nerve damage, tumor, glaucoma, and a number of other eye issues.n afferent pupillary defect may be a sign of damage to the optic nerve. An afferent pupillary defect may be a sign of glaucoma or other eye conditions.
This is known as 'constriction for accommodation to near vision'. If the pupils are unequal in size with uniform illumination, or if their reaction to light is unequal, the physician will attempt to explore the cause for this. The variety of reasons for such occurrences are beyond the scope of a Quora answer. Both pupils fully dilated and non reactive to light indicates death.