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If an autoimmune disease destroys the body's platelets, thrombocytopenia can occur. One example of this type of autoimmune disease is immune thrombocytopenia (ITP). ITP is a bleeding disorder in which the blood doesn't clot as it should.
Drugs like aspirin, clopidogrel, and ticlopidine that prevent thrombosis or stroke by inhibiting platelet function. The effect of these drugs is irreversible for the life of the platelet. The average platelet's lifespan is 7 to 10 days with about 10% of circulating platelets being replaced every 24 hours.