There is a lack of studies specifically examining the relationship between change in depression severity over time in individuals with bipolar disorder and change in the nature and magnitude of abnormal neural activity during emotion and cognitive challenge tasks.he attainment of this goal can be facilitated by identifying biomarkers reflecting pathophysiologic processes in bipolar disorder, namely impaired emotion regulation, impaired attention, and distractibility, which persist during depression and remission and are not common to unipolar depression.
The Federalist (later known as The Federalist Papers) is a collection of 85 articles and essays written by Alexander Hamilton, James Madison, and John Jay (under the pseudonym Publius) promoting the ratification of the United States Constitution.
Quick Answer. The Federalist Papers were written in an attempt to get the New York citizens to ratify the United States Constitution in 1787. They were originally published using a pen name, Publius, before being published in 1818 with the author's real names, which were James Madison, John Jay and Alexander Hamilton.