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The Five Spanish Missions of Old San Antonio A chain of five missions established along the San Antonio River in the 18th century became the largest concentration of Catholic missions in North America.ission San Francisco de la Espada, like its sister missions San Jose, San Juan, and Concepcion, had its beginnings in East Texas. Originally named San Francisco de los Tejas, Espada was renamed and relocated to San Antonio in 1731. It is the southernmost of the chain of missions located on the San Antonio River.
Other sources list a fourth church after 1680, San Lorenzo, on the Texas side, but this appears to have been primarily a settlement of the Spanish refugees and was not a mission for Indians. But historian Robert S. Weddle says San Lorenzo later became a mission in 1726.he missionaries wanted to return to the area, but with the arrival of the La Salle Expedition on the Texas coast in 1685, the Spanish government decided to concentrate its energies on East Texas. East Texas Missions. Efforts were turned to East Texas in 1690.