1 The results of prophylactic measures for femoral head AVN have considerable variation, but certain generalizations can safely be stated. 2  Namely, the clinical results of core decompression alone deteriorate with more advanced lesions.
1 Melasma is very common skin ailment. It can occur to anyone, but young women with brownish tone are more likely to contract with it.  The condition is often linked with female hormonal changes. Change in level of estrogen and progesterone may cause melasma.
The finding that both germline and somatic BRCA1 mutations are accompanied by loss of heterozygosity, suggests that loss of this tumor suppressor gene is a critical event in the development of these cancers.