There is a lack of studies specifically examining the relationship between change in depression severity over time in individuals with bipolar disorder and change in the nature and magnitude of abnormal neural activity during emotion and cognitive challenge tasks.he attainment of this goal can be facilitated by identifying biomarkers reflecting pathophysiologic processes in bipolar disorder, namely impaired emotion regulation, impaired attention, and distractibility, which persist during depression and remission and are not common to unipolar depression.
The Federalist (later known as The Federalist Papers) is a collection of 85 articles and essays written by Alexander Hamilton, James Madison, and John Jay (under the pseudonym Publius) promoting the ratification of the United States Constitution.
Beginning on October 27, 1787 the Federalist Papers were first published in the New York press under the signature of Publius. These papers are generally considered to be one of the most important contributions to political thought made in America. The essays appeared in bookform in 1788, with an introduction by Hamilton.