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Less serious Valtrex side effects may include: nausea, stomach pain; headache, dizziness, tired feeling, depression; joint pain; menstrual pain; mild skin rash; or. stuffy nose, sore throat. This is not a complete list of side effects and others may occur.
Many people who take Valtrex notice some relief from symptoms within 2 or 3 days, with healing of the blisters after about a week. Again, the sooner during an outbreak a person starts taking Valtrex, the shorter and less severe the outbreak generally is.