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Less serious Valtrex side effects may include: nausea, stomach pain; headache, dizziness, tired feeling, depression; joint pain; menstrual pain; mild skin rash; or. stuffy nose, sore throat. This is not a complete list of side effects and others may occur.
The most common side effects (15 - 30% of patients) are gastrointestinal: anorexia, nausea, and vomiting are usually transient. CNS side effects include sedation, ataxia, and tremor. Valproic acid increases the plasma concentration of phenobarbital and primidone, and has a variable effect on phenytoin levels.