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Less serious Valtrex side effects may include: nausea, stomach pain; headache, dizziness, tired feeling, depression; joint pain; menstrual pain; mild skin rash; or. stuffy nose, sore throat. This is not a complete list of side effects and others may occur.
1 VALTREX (valacyclovir hydrochloride) may affect other medicines, and other medicines may affect VALTREX (valacyclovir hydrochloride) . 2  It is a good idea to keep a complete list of all the medicines you take.3  Show this list to your healthcare provider and pharmacist any time you get a new medicine. VALTREX (valacyclovir hydrochloride) may affect other medicines, and other medicines may affect VALTREX (valacyclovir hydrochloride) . 2  It is a good idea to keep a complete list of all the medicines you take.