When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
From Wikipedia, the free encyclopedia. The oldest operating McDonald's restaurant is a drive-up hamburger stand at 10207 Lakewood Boulevard at Florence Avenue in Downey, California. It was the third McDonald's restaurant, and opened on August 18, 1953.t was the second restaurant franchised by Richard and Maurice McDonald, prior to the involvement of Ray Kroc in the company, and it still has the two original 30-foot (9.1 m)  Golden Arches  and a 60-foot (18 m) animated neon  Speedee  sign that was added in 1959.