When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
White Castle is an American regional hamburger restaurant chain in the Midwestern and Mid-Atlantic United States, generally credited as the first fast-food chain in the United States. It is known for its small, square hamburgers.