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Prescription drugs that may cause bullous pemphigoid include penicillin, etanercept (Enbrel), sulfasalazine (Azulfidine) and furosemide (Lasix). Light and radiation. Ultraviolet light therapy to treat certain skin conditions may trigger bullous pemphigoid, as can radiation therapy to treat cancer.
1 Bullous pemphigoid causes less severe blisters that heal faster and are not life-threatening; this condition is seen mostly in elderly people.  Dermatitis herpetiformis causes small, itchy blisters; it is a chronic condition that usually starts in early adulthood. It is associated with gluten sensitivity.