Double relapsed and/or refractory multiple myeloma (DRMM), MM that is relapsed and/or refractory to bortezomib and lenalidomide , carries a poor prognosis and therapeutic options remain limited. An IMWG retrospective analysis of patients who relapsed following bortezomib and at least one of the IMiDs showed a median overall survival (OS) and progression-free survival (PFS) of 9 months and 5 months respectively .
Slavery was a divisive issue and was one of the primary causes of the American Civil War. The Thirteenth Amendment to the United States Constitution, ratified in 1865, abolished slavery throughout the United States, and the distinction ended.lavery was a divisive issue and was one of the primary causes of the American Civil War. The Thirteenth Amendment to the United States Constitution, ratified in 1865, abolished slavery throughout the United States, and the distinction ended.
Slavery in the United States was the legal institution of human chattel slavery that existed in the United States of America in the 18th and 19th centuries after it gained independence and before the end of the American Civil War.mplemented in colonial Louisiana in 1724, Louis XIV of France 's Code Noir regulated the slave trade and the institution of slavery in the French colonies. It gave Louisiana a very different pattern of slavery compared to the rest of the United States.