Drugs administered into the proximal rectum are subjected to first-pass metabolism. However, drugs administered from a low rectal site reach the general circulation without first passing through the liver. The unpredictability of this route is largely explained by whether the drug passes through the liver or not.rugs administered into the proximal rectum are subjected to first-pass metabolism. However, drugs administered from a low rectal site reach the general circulation without first passing through the liver. The unpredictability of this route is largely explained by whether the drug passes through the liver or not.
Answered by The Community. Making the world better, one answer at a time. Black history month began as negro history week by Carter G. Woodson. It was the third week in February to coincide with Lincoln's birthday on the 12th as well as Frederick Douglas birthday on the 14th.
- Dr. Carter G. Woodson (1875-1950) on founding Negro History Week, 1926. Dr. Carter G. Woodson, considered to be a pioneer in the study of African American history, is given much of the credit for Black History Month. The son of former slaves, Woodson spent his childhood working in coalmines and quarries. He received his education during the four-month term that was customary for black schools at the time.