When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
By DOUGLAS MARTIN. Dave Thomas, an orphan who went to work in restaurants at 12 and by dint of hard work, quality control and shrewd marketing made Wendy's the third-largest hamburger chain in the world, died yesterday.