Cervical spine fractures can occur secondary to exaggerated flexion or extension, or because of direct trauma or axial loading. Pathology. The cervical spine is susceptible to injury because it is highly mobile with relatively small vertebral bodies and supports the head which is both heavy and acts as a lever.
The inactive molecule pepsinogen is cleaved in a strongly acidic environment to give off the active enzyme, pepsin. Pepsinogen is produced in the stomach by chief cells.
Activation of pepsinogen in the stomach. The peptidase in the stomach is pepsin. Pepsin works optimally in the acidic environment of the stomach, being active at pH 2-3, but becoming inactivated when the pH is above 5. The chief cells at the base of the gastric glands secrete the zymogen, which is called pepsinogen.Activation of pepsinogen starts when hydrocholoric acid (HCl) , which is secreted by the parietal cells partially activates pepsinogen (pepsinogen* in figure).This partially active enzyme then cleaves the peptide from other pepsinogen molecules to form active pepsin.he chief cells at the base of the gastric glands secrete the zymogen, which is called pepsinogen. Activation of pepsinogen starts when hydrocholoric acid (HCl) , which is secreted by the parietal cells partially activates pepsinogen (pepsinogen* in figure).