1 The most common causes of pleural effusion are congestive heart failure, pneumonia, malignancies and pulmonary embolism. 2  Signs and symptoms of pleural effusion include: 3  Shortness of breath. 4  Chest pain. 5  Associate symptoms of pleural effusion due to an underlying disease include: 6  Night sweats. 7  Coughing up blood. 8  Fever.
Leg Pain. Varicose vein disease is a common and often underappreciated cause of leg pain. Varicose veins may be overlooked as a cause of leg pain because not all varicose veins bulge on the surface; some are invisible and located deeper in the leg. Leaking varicose veins cause blood to pool and waste products to accumulate in the leg.
The legs have a network of veins. These veins have hundreds of one way valves that help the return of blood back to the heart. Venous reflux disease develops when one or more of these valves fail, causing blood to pool in the legs. The veins dilate causing varicose veins and spider veins to develop. Achy, tired, heavy, painful, and fatigued legs can develop as a result of venous reflux. Leg swelling can occur. Skin itching and burning can occur.