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While the supplement may help you add calorie-burning muscle, some women may notice the number on the scale go up after taking creatine. That's because creatine supplementation causes your muscles to retain water, which may add extra weight.
The Iranian researchers concluded that since myostatin levels were lower in the subjects taking creatine, one way that creatine may work to increase muscle size and strength is by reducing myostatin levels, which reduces the limitation that this protein places on muscle growth.