Monistat Cream. Monistat cream is an over-the-counter vaginal yeast infection remedy that comes in several different strengths. Over-the-counter feminine hygiene products like Monistat can be a great option for busy women who doesn't have time to go to the gynecologist for basic feminine needs.onistat 1 is the strongest formulation of Monistat cream and can allow for overnight yeast infection treatment in ideal situations. Monistat 3 is the midrange Monistat cream and is made to run on a three day treatment schedule, but runs a lower risk of skin irritation.
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