Titin is a giant protein responsible for muscle elasticity and provides a scaffold for several sarcomeric proteins, including the novel titin-binding protein MURF-1, which binds near the titin M-line region.
ORIF Surgery for Proximal Humerus Fracture. This surgical procedure repairs a break in the proximal end of the humerus. ORIF stands for Open Reduction Internal Fixation. During this procedure, an incision will be made and a metal plate will be attached to the humerus to hold the bone in place while it heals. Preparation.
Currently, a greater tuberosity that is displaced 5 mm or more is commonly considered a fragment that should be reduced. Contraindications for repair of proximal humerus fractures include inability to tolerate the procedure medically and lack of clearance for surgery through the primary care physician or specialty consultants (ie, cardiologist, vascular specialist).