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Certain medications may also lead to a low white blood cell count because they can destroy white blood cells or damage the bone marrow. For example, taking antibiotics may sometimes cause an abnormal drop in neutrophils, a condition known as neutropenia.
1 Leukopenia-a decrease in the total number of white blood cells (WBC), which may lead to low white blood cell count. 2  Neutropenia-a decrease in the number of neutrophils, one type of white blood cell, which may lead to low white blood cell count.lood cells; red blood cells, white blood cells and platelets are made by the bone marrow. These blood cells divide quickly. Chemotherapy may lead to low blood counts, causing the possibility of a variety of symptoms. The symptoms depend on the type of low blood cell count.