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The damage to the femoral nerve can be caused by compression, trauma, and disease such as diabetes. Patients suffering from femoral neuropathy complain of pain that radiates into the front of the thigh and the mid-calf and is associated with weakness of the quadriceps muscle causing the knee to buckle.he damage to the femoral nerve can be caused by compression, trauma, and disease such as diabetes. Patients suffering from femoral neuropathy complain of pain that radiates into the front of the thigh and the mid-calf and is associated with weakness of the quadriceps muscle causing the knee to buckle.
The femoral nerve is a nerve in the thigh that supplies skin on the upper thigh and inner leg, and the muscles that extend the knee.1  1 Structure. Anterior cutaneous branches: The anterior cutaneous branches comprise the following nerves: intermediate femoral cutaneous nerve and medial femoral cutaneous nerve (Note the lateral femoral cutaneous nerve is a branch from the lumbar plexus.).