When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
In the â90s, Karcherâs partnership, CKE Restaurants, set its sights on another hamburger chain. Wilbur Hardee had opened his first restaurant in North Carolina in 1961; soon Hardeeâs became a familiar fast food sight in the Midwest and South.