When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
Dave Thomas opened his first Wendy's Old Fashioned Hamburgers in downtown Columbus in November, 1969. Before launching Wendy's, 35-year old Dave spent his career studying the fast food chain business from the inside out.