Tretinoin was co-developed for its use in acne by James Fulton and Albert Kligman when they were at University of Pennsylvania in the late 1960s. The University of Pennsylvania held the patent for Retin-A, which it licensed to pharmaceutical companies.
/ËÊnËkÉËnstÉËtuËÊÉnlÌ/ /ËÊnËkÉnstÉËtjuËÊÉnlÌ/. adjective. Learner's definition of UNCONSTITUTIONAL. : not allowed by the constitution of a country or government: not constitutional.ËÊnËkÉËnstÉËtuËÊÉnlÌ/ /ËÊnËkÉnstÉËtjuËÊÉnlÌ/. adjective. Learner's definition of UNCONSTITUTIONAL. : not allowed by the constitution of a country or government: not constitutional.
Lesson Summary: The issue of whether or not acts of government are considered unconstitutional is up to the Supreme Court, established by the U.S. Constitution and the federal court system, created by the Judiciary Act of 1789.ome Examples of Unconstitutionality. The Court has often ruled that acts of government are violations of the Constitution. One of the most infamous was the 1819 case McCulloch v. Maryland, in which the Court ruled that a state had no right to tax a federal institution (in that case, a bank).