When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
Who owned Judy's Hamburger chain? Though many tout Wendy's Dave Thomas as the founder of the idea - history argues from a different view point. According to local lore while Dave Thomas was managing/ owning 3 â¦(or 4) places to eat that were failing; he turned them into KFC's. While there, during the age of McDonald's & Burger war's - a guy working with him came up with a plan to market hamburger's - without having to freeze the meat.