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Patients with cardiomyopathy, a stiffening and thickening of the heart muscle that weakens it, may develop an enlarged heart as it labors to pump an adequate supply of blood to the body. Coronary artery disease, in which plaque in the arteries interferes with the flow of blood, can cause the heart to enlarge.
Main Content: Enlarged heart (LVH) and high blood pressure. If you have high blood pressure, this means that your heart has to work harder to push blood round your body. To cope with this extra effort, your heart muscles become thicker and stiffer, which can make the heart become enlarged.