When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
There are currently three major claims staked on the confusing and contradictory map of American hamburger history. Each has its adherents and detractors. Louis' Lunch: This New Haven, Connecticut, burger joint claims to have invented our favorite lunchtime (and dinnertime) meal in 1900.