When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
Company Overview. The Wendy's Company is the 3rd largest company for quick service hamburger in the world. The story of Wendy's Company began in 1969 when Dave Thomas opened the first of Wendy's restaurant in Columbus, Ohio. This saw a new dawn in the food industry with Wendy's developing a method of preparing fresh hamburgers on order instead of relying on the old frozen beef and mass production of food used by other restaurants.