In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
Signs and symptoms of gout include: 1  Hyperuricemia (high level of uric acid in the blood). 2  Uric acid crystals in joint fluid. 3  More than one attack of acute arthritis. 4  Arthritis that develops in 1 day, producing a swollen, red, and warm joint. 5  Attack of arthritis in only one joint, usually the toe, ankle, or knee.