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Muscles need probably 48 hours of rest but soreness can last a little longer, especially if your new to working out. After workout and even days after make sure to stretch, yoga is great for healing your sore muscles as well as making these muscles more flexible! Go easy if you are new, First Day At The Gym Workout.
DOMS will kick in 24 to 48 hours after your squats workout or other significant exertion of your muscles. Your quadriceps will need up to 72 hours after that workout to repair the tissue strain caused by weight training. Some treatments, supplements or nutrients may help alleviate some of the discomfort from DOMS, but your muscles will need that two-to three-day timeline to fully recover from a significant workout.