When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
Best Answer: The answer is really quite simple: because Hamburg, Germany made the first hamburgers. However, the history of the hamburger is actually more complicated. Who actually invented the first hamburger remains a mystery. Some say it was a group of nomadic people called the Tartars who tenderized their beef by placing it under a horse's saddle--flattening it into a patty.