Drugs administered into the proximal rectum are subjected to first-pass metabolism. However, drugs administered from a low rectal site reach the general circulation without first passing through the liver. The unpredictability of this route is largely explained by whether the drug passes through the liver or not.rugs administered into the proximal rectum are subjected to first-pass metabolism. However, drugs administered from a low rectal site reach the general circulation without first passing through the liver. The unpredictability of this route is largely explained by whether the drug passes through the liver or not.
Answered by The Community. Making the world better, one answer at a time. Black history month began as negro history week by Carter G. Woodson. It was the third week in February to coincide with Lincoln's birthday on the 12th as well as Frederick Douglas birthday on the 14th.
Since its inception in 1926, Negro History Week and Black History Month have been given annual themes. The first annual theme was simply, The Negro in History, but since then the themes have grown more specific. Here is a list of the most current and future themes for Black History Month.