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A peptic ulcer is a sore on the lining of your stomach or the first part of your small intestine (duodenum). If the ulcer is in your stomach, it is called a gastric ulcer. If the ulcer is in your duodenum, it is called a duodenal ulcer. Ulcers are fairly common.
Peptic Ulcer Disease - Topic Overview. A peptic ulcer is a sore in the inner lining of the stomach or upper small intestine . Ulcers form when the intestine or stomach's protective layer is broken down. When this happens, digestive juices-which contain hydrochloric acid and an enzyme called pepsin-can damage the intestine or stomach tissue.