When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
McDonald's , with almost 16,000 outlets, is the largest fast-food hamburger chain in the United States. Many of the states where McDonald's iconic Golden Arches dominate the landscape are also, coincidentally, states with the highest rates of obesity and deaths due to heart disease.