Adrenal insufficiency - Causes. 1  Causes of acute adrenal insufficiency are mainly sudden withdrawal of long-term corticosteroid therapy, Waterhouse-Friderichsen syndrome, and stress in people with underlying chronic adrenal insufficiency.
Lipoatrophy is a common complication of protease inhibitor administration in HIV patients. These are antiretroviral medications that may lead to central fat accumulation and fat tissue loss in other parts of the body. Lipoatrophy caused by HIV medications are usually generalized or total.
HMG-CoA reductase, a rate-controlling enzyme of cholesterol synthesis. Activity of the enzyme may be as much as 60 times higher than normal in patients with low-density lipoprotein receptor disorder.