Dam. a hydraulic-engineering structure that blocks off a river or other watercourse to raise the water level behind itself, to create a head at its location, and to create a reservoir. The significance of dams for water management is diverse.
(verify) Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of irregular heartbeats. This includes ventricular tachycardia (VT), ventricular fibrillation (VF), and wide complex tachycardia, as well as atrial fibrillation and paroxysmal supraventricular tachycardia.
Pathophysiology. Amiodarone causes a wide spectrum of effects on the thyroid. Amiodarone inhibits type 1 5'-deiodinase enzyme activity, thereby decreasing the peripheral conversion of T4 to triiodothyronine (T3) and reducing the clearance of both T4 and reverse T3 (rT3).