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Patients with cardiomyopathy, a stiffening and thickening of the heart muscle that weakens it, may develop an enlarged heart as it labors to pump an adequate supply of blood to the body. Coronary artery disease, in which plaque in the arteries interferes with the flow of blood, can cause the heart to enlarge.
Causes of Heart block. Heart block is caused by certain medications, surgery and primary disease (an infection). A child can also be born with heart block (congenital heart block). Following is a list of causes or underlying conditions (see also Misdiagnosis of underlying causes of Heart block) that could possibly cause Heart block includes: 1  Heart attack. 2  Coronary artery disease. 3  Sinus node disease.  Congenital heart defect.