Double relapsed and/or refractory multiple myeloma (DRMM), MM that is relapsed and/or refractory to bortezomib and lenalidomide , carries a poor prognosis and therapeutic options remain limited. An IMWG retrospective analysis of patients who relapsed following bortezomib and at least one of the IMiDs showed a median overall survival (OS) and progression-free survival (PFS) of 9 months and 5 months respectively .
Slavery was a divisive issue and was one of the primary causes of the American Civil War. The Thirteenth Amendment to the United States Constitution, ratified in 1865, abolished slavery throughout the United States, and the distinction ended.lavery was a divisive issue and was one of the primary causes of the American Civil War. The Thirteenth Amendment to the United States Constitution, ratified in 1865, abolished slavery throughout the United States, and the distinction ended.
The 13th Amendment. In 1865, the 13th Amendment outlawing slavery was added to the U.S. Constitution. Interesting Facts about Slavery in the United States. The international slave trade was outlawed by Britain in 1807 and the United States in 1808. However, slavery was still legal and slaves were smuggled into the country up until the end of the Civil War.