Average roof area of a mid terrace house is 55m 2 so the price of a new terraced roof is about Â£ 4000 this is how I came up with this figure. 1  Normal grade tanalised roofing battens (tiling lath) Â£100. 2  New milled lead valley plus sundries Â£100.
Without enough functional alpha-1 antitrypsin, neutrophil elastase destroys the small air sacs in the lungs (alveoli) and causes lung disease. Excessive damage to the alveoli leads to emphysema, an irreversible lung disease that causes extreme shortness of breath.ore than 120 mutations in the SERPINA1 gene have been identified. Some of these mutations do not affect the production of alpha-1 antitrypsin, while others cause a shortage (deficiency) of the protein.
Porcine pancreatic elastase is composed of a single peptide chain of 240 amino acids, and contains 4 disulfide bridges (Sawyer et al. 1973). It has a high degree of sequence identity with pancreatic elastases from other species, such as rat with whom it shares 86% identity (MacDonald et al. 1982).n adsorption complex between elastase and its substrate is formed, followed by nucleophilic attack (S214) to form an acyl-enzyme intermediate, and release of the first product (the C-terminal end of the substrate).