When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
White Castle also used the first ever industrial strength spatula, manufactured the first mass-produced paper hat, and was the first to sell frozen fast food. White Castle has been extremely popular as a hamburger chain for as long as eating hamburgers was trendy.hite Castle was the first fast food hamburger company to ever sell not only a million burgers, but also to sell a billion burgers as well. The first White Castle was opened in 1921 with only $700 worth of borrowed money.