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Certain medications may also lead to a low white blood cell count because they can destroy white blood cells or damage the bone marrow. For example, taking antibiotics may sometimes cause an abnormal drop in neutrophils, a condition known as neutropenia.
Autoimmune diseases that attack your white blood cells can also lead to a low WBC count. Several different prescribed drugs, including chemotherapy, are known to decrease WBC production or destroy WBCs. A low WBC count can be serious because it increases your risk of developing a potentially life-threatening infection.