Angelman syndrome (AS) is a rare neuro-genetic disorder that occurs in one in 15,000 live births. Angelman syndrome is often misdiagnosed as cerebral palsy or autism due to lack of awareness. Characteristics of the disorder include developmental delay, lack of speech, seizures, and walking and balance disorders. Individuals with Angelman syndrome will require life-long care.
Description of Estrogen receptor assay. Estrogen receptor assay: A laboratory test that evaluates the benefits of hormone treatment for a patient diagnosed with breast cancer.
Estrogen receptors also occur within the cell nucleus, and both estrogen receptor subtypes have a DNA-binding domain and can function as transcription factors to regulate the production of proteins. The receptor also interacts with activator protein 1 and Sp-1 to promote transcription, via several coactivators such as PELP-1.