When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
About Hamburger Festival. Legend has it that it was two brothers from Akron, Ohio who created the hamburger back in 1885. On the final day of the New York State Fair in Hamburg, NY, Akron natives Frank and Charles Menches ran out of pork for the sandwiches they were vending from their concession booth.