Tretinoin was co-developed for its use in acne by James Fulton and Albert Kligman when they were at University of Pennsylvania in the late 1960s. The University of Pennsylvania held the patent for Retin-A, which it licensed to pharmaceutical companies.
/ËÊnËkÉËnstÉËtuËÊÉnlÌ/ /ËÊnËkÉnstÉËtjuËÊÉnlÌ/. adjective. Learner's definition of UNCONSTITUTIONAL. : not allowed by the constitution of a country or government: not constitutional.ËÊnËkÉËnstÉËtuËÊÉnlÌ/ /ËÊnËkÉnstÉËtjuËÊÉnlÌ/. adjective. Learner's definition of UNCONSTITUTIONAL. : not allowed by the constitution of a country or government: not constitutional.
But these appointments must be approved by the Senate. The Congress can pass a law, but the President can veto it. The Supreme Court can rule a law to be unconstitutional, but the Congress, with the States, can amend the Constitution. All of these checks and balances, however, are inefficient. But that's by design rather than by accident.