When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
Chances are pretty good that you've visited (or at least heard of!) Five Guys, the burger restaurant that's taking over America. But how much do you really know about the chain? Five Guys Burgers & Fries began back in 1986 as a family affair: husband-and-wife team Jerry and Janie Murrell in Arlington, Virginia.