When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
This change in location and ten-year hiatus surrendered the title of America's oldest continuously operating pizzeria to Papa's Tomato Pies in Trenton, New Jersey, which opened in 1912 and has sold pies without interruption since. The relocated, reopened Lombardi's uses a coal oven to bake its pies the way the original did.