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A peptic ulcer is a sore on the lining of your stomach or the first part of your small intestine (duodenum). If the ulcer is in your stomach, it is called a gastric ulcer. If the ulcer is in your duodenum, it is called a duodenal ulcer. Ulcers are fairly common.
Overview of Peptic Ulcer Disease Peptic ulcer disease (PUD) is a chronic (long lasting) condition that affects the gastrointestinal (GI) tract or digestive system. PUD causes ulcers (sores or lesions) in the lining (mucosa) of the stomach or first part of the small intestine (duodenum).