When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
Wendyâs was founded in 1969 and is today the third largest hamburger fast food restaurant in the world, following McDonaldâs and Burger King. It has over 6,600 locations. Because they compete with those two restaurants, Wendyâs prices match those restaurants as well.