When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
Shawâs is one of the oldest continuously operated supermarkets in the United States withNew England roots that were firmly planted in 1860, when George C. Shaw opened his first store in Portland, Maine.