Tretinoin was co-developed for its use in acne by James Fulton and Albert Kligman when they were at University of Pennsylvania in the late 1960s. The University of Pennsylvania held the patent for Retin-A, which it licensed to pharmaceutical companies.
/ËÊnËkÉËnstÉËtuËÊÉnlÌ/ /ËÊnËkÉnstÉËtjuËÊÉnlÌ/. adjective. Learner's definition of UNCONSTITUTIONAL. : not allowed by the constitution of a country or government: not constitutional.ËÊnËkÉËnstÉËtuËÊÉnlÌ/ /ËÊnËkÉnstÉËtjuËÊÉnlÌ/. adjective. Learner's definition of UNCONSTITUTIONAL. : not allowed by the constitution of a country or government: not constitutional.
Under the overbreadth doctrine, a statute that affects First Amendment rights is unconstitutional if it prohibits more protected speech or activity than is necessary to achieve a compelling government interest.