Double relapsed and/or refractory multiple myeloma (DRMM), MM that is relapsed and/or refractory to bortezomib and lenalidomide , carries a poor prognosis and therapeutic options remain limited. An IMWG retrospective analysis of patients who relapsed following bortezomib and at least one of the IMiDs showed a median overall survival (OS) and progression-free survival (PFS) of 9 months and 5 months respectively .
Slavery was a divisive issue and was one of the primary causes of the American Civil War. The Thirteenth Amendment to the United States Constitution, ratified in 1865, abolished slavery throughout the United States, and the distinction ended.lavery was a divisive issue and was one of the primary causes of the American Civil War. The Thirteenth Amendment to the United States Constitution, ratified in 1865, abolished slavery throughout the United States, and the distinction ended.
Slavery ended in the United States 6 months after the civil war with the 13th Amendment. December 6, 1865. In the US, slavery ended in December of 1865 when the 13th Amendment was ratified. The Blacks were officially freed from slavery by the Thirteenth Amendment, passed by the Senate on Apr. 8, 1864, passed by the House on Jan.31,1865 and proclaimed as adopted on Dec. 6,1865.