Drugs administered into the proximal rectum are subjected to first-pass metabolism. However, drugs administered from a low rectal site reach the general circulation without first passing through the liver. The unpredictability of this route is largely explained by whether the drug passes through the liver or not.rugs administered into the proximal rectum are subjected to first-pass metabolism. However, drugs administered from a low rectal site reach the general circulation without first passing through the liver. The unpredictability of this route is largely explained by whether the drug passes through the liver or not.
Answered by The Community. Making the world better, one answer at a time. Black history month began as negro history week by Carter G. Woodson. It was the third week in February to coincide with Lincoln's birthday on the 12th as well as Frederick Douglas birthday on the 14th.
Black History Month is an annual celebration of achievements by African Americans and a time for recognizing the central role of blacks in U.S. history. The event grew out of âNegro History Week,â the brainchild of noted historian Carter G. Woodson and other prominent African Americans.