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(For our list of subjects with an imprinting defect, click here.). UBE3A Mutation. Malfunction of the UBE3A gene on the maternal chromosome #15 seems to be the cause of Angelman syndrome. In the case of a UBE3A mutation, there is a mistake in the genetic code of the UBE3A gene.
Prevelance statistics about Angelman syndrome: The following statistics relate to the prevalence of Angelman syndrome: Angelman Syndrome affects all races and sexes equally in the US (Dr Harry Angelman, Angelman Syndrome Foundation) There are 1000 to 5000 cases of Angelman Syndrome in the US and Canada (Dr Harry Angelman, Angelman Syndrome Foundation)