When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
Synopsis. After complaining that he couldn't find a good hamburger in Columbus, Ohio, Dave Thomas opened his own restaurant on November 15, 1969: Wendy's, named after Thomas's 8-year-old daughter. Wendy's quickly caught on, and within less than a decade, had grown into a 1,000-store franchise.