When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
The two burger chains started out as totally separate entities, one in the West and one in the East. Carlâs Jr. is the elder statesman of the two, founded as a Los Angeles hot dog stand in 1941 by Carl Karcher. Business thrived, and five years later there were five full-sized Carlâs Drive-In Barbecue restaurants, which by then had begun serving hamburgers.