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Anaphylactic reactions are excluded by the presence of red plasma or urine, discordant pretransfusion and posttransfusion ABO blood types, or a positive direct antiglobulin (Coombs) test result. Demonstration of anti-IgA in a pretransfusion sample of the recipient's serum or plasma establishes the diagnosis.
On detecting any signs or symptoms of reaction: 1  Stop the transfusion immediately, and notify the physician. 2  Disconnect the transfusion set-but keep the IV line open with 0.9% saline to provide access for possible IV drug infusion. 3  Send the blood bag and tubing to the blood bank for repeat typing and culture.