Double relapsed and/or refractory multiple myeloma (DRMM), MM that is relapsed and/or refractory to bortezomib and lenalidomide , carries a poor prognosis and therapeutic options remain limited. An IMWG retrospective analysis of patients who relapsed following bortezomib and at least one of the IMiDs showed a median overall survival (OS) and progression-free survival (PFS) of 9 months and 5 months respectively .
Slavery was a divisive issue and was one of the primary causes of the American Civil War. The Thirteenth Amendment to the United States Constitution, ratified in 1865, abolished slavery throughout the United States, and the distinction ended.lavery was a divisive issue and was one of the primary causes of the American Civil War. The Thirteenth Amendment to the United States Constitution, ratified in 1865, abolished slavery throughout the United States, and the distinction ended.
Britain abolished slavery throughout the British Empire with the Slavery Abolition Act 1833, the French colonies re-abolished it in 1848 and the U.S. abolished slavery in 1865 with the 13th Amendment to the U.S. Constitution.