When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
Wendy's: Former KFC franchise owner Dave Thomas opened the first Wendy's location on Nov. 15, 1969, in Columbus, Ohio. The following year, Thomas opened a second location, this time adding a drive-through pickup window.hite Castle: The first White Castle location opened in 1921 in Wichita, making it the original American fast-food burger chain. Founder Bill Ingram used $700 to open the starting location and started serving the chain's signature sliders.