In bacteria, transcription begins with the binding of RNA polymerase to the promoter in DNA. RNA polymerase is a core enzyme consisting of five subunits: 2 Î± subunits, 1 Î² subunit, 1 Î²' subunit, and 1 Ï subunit.
Untreated gout can cause a risk for diabetes and heart disease. Chronic gout can also cause kidney stones. Gout is caused by a buildup of uric acid in the blood. It cristalizes in the joints, with the big toe being the location in half of the cases. This is called podagra.
Salicylate, which is a main ingredient of aspirin and other analgesics, can also trigger an attack of gout. Even though these medications are often used in the treatment of gout pain, they can sometimes interfere with the kidney's ability to eliminate uric acid and thus may trigger more gout attacks.