When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
The âburgerâ is an American short, a nickname, for the âhamburgerâ. Our hamburger started off as Hamburg steak in the late 19thC, courtesy of German immigrants bringing and incorporating their dietary preference from the city of Hamburg, where pounded beef had become a popular entree.