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Anaphylactic reactions are excluded by the presence of red plasma or urine, discordant pretransfusion and posttransfusion ABO blood types, or a positive direct antiglobulin (Coombs) test result. Demonstration of anti-IgA in a pretransfusion sample of the recipient's serum or plasma establishes the diagnosis.
The first blood transfusion in recorded history took place in 1665. Before the discovery of blood typing, doctors did not perform any screening tests before a transfusion. Some early blood transfusion devices were nothing more than a tube system to transport blood from the donor directly into the veins of the recipient.