1 The most common causes of pleural effusion are congestive heart failure, pneumonia, malignancies and pulmonary embolism. 2  Signs and symptoms of pleural effusion include: 3  Shortness of breath. 4  Chest pain. 5  Associate symptoms of pleural effusion due to an underlying disease include: 6  Night sweats. 7  Coughing up blood. 8  Fever.
Leg Pain. Varicose vein disease is a common and often underappreciated cause of leg pain. Varicose veins may be overlooked as a cause of leg pain because not all varicose veins bulge on the surface; some are invisible and located deeper in the leg. Leaking varicose veins cause blood to pool and waste products to accumulate in the leg.
Chronic venous insufficiency (CVI) results when the veins in the legs no longer pump blood back to the heart effectively. Normally, when the leg muscles contract, they squeeze the deep veins of the legs, aiding in circulation. Veins contain one-way valves that keep the blood from flowing in the opposite direction, toward the foot. These valves can wear out over time, leading to blood leaking backward and pooling in the veins of the leg.