Drugs administered into the proximal rectum are subjected to first-pass metabolism. However, drugs administered from a low rectal site reach the general circulation without first passing through the liver. The unpredictability of this route is largely explained by whether the drug passes through the liver or not.rugs administered into the proximal rectum are subjected to first-pass metabolism. However, drugs administered from a low rectal site reach the general circulation without first passing through the liver. The unpredictability of this route is largely explained by whether the drug passes through the liver or not.
Answered by The Community. Making the world better, one answer at a time. Black history month began as negro history week by Carter G. Woodson. It was the third week in February to coincide with Lincoln's birthday on the 12th as well as Frederick Douglas birthday on the 14th.
Since 1976, every U.S. president has officially designated the month of February as Black History Month. Other countries around the world, including Canada and the United Kingdom, also devote a month to celebrating black history. 1  Play video The Civil War and Its Legacy. 2  Play video Sound Smart: The Black Panthers. 3  Play video David Gilmore.