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Patients with cardiomyopathy, a stiffening and thickening of the heart muscle that weakens it, may develop an enlarged heart as it labors to pump an adequate supply of blood to the body. Coronary artery disease, in which plaque in the arteries interferes with the flow of blood, can cause the heart to enlarge.
Abnormal growths may cause an enlarged liver. This may result from: An enlarged liver may occur as a result of one or more of these causes. Inflammation or fatty liver may cause an enlarged liver and may result from: 1  An infection such as a from a virus or abscess. 2  Certain medications. 3  Toxins. 4  Certain types of hepatitis, including alcoholic hepatitis.