Adrenal insufficiency - Causes. 1  Causes of acute adrenal insufficiency are mainly sudden withdrawal of long-term corticosteroid therapy, Waterhouse-Friderichsen syndrome, and stress in people with underlying chronic adrenal insufficiency.
Lipoatrophy is a common complication of protease inhibitor administration in HIV patients. These are antiretroviral medications that may lead to central fat accumulation and fat tissue loss in other parts of the body. Lipoatrophy caused by HIV medications are usually generalized or total.
The metabolic effects usually associated with the lipodystrophy syndrome include: 1  Fat redistribution, including lipohypertrophy (central) and lipoatrophy (predominantly face and lower limbs). 2  Insulin resistance (hyperglycaemia). 3  Dyslipidaemia (raised total cholesterol and triglycerides, lowered high-density lipoprotein (HDL) cholesterol).