Other causes of chronic ankle pain include: 1  An injury to the nerves that pass through the ankle. 2  A torn or inflamed tendon. 3  Arthritis of the ankle joint.  A fracture in one of the bones that make up the ankle 1  joint. An inflammation of the joint lining (synovium)  The development of scar tissue in the ankle after a sprain.
Down syndrome can affect the nervous system of the body by causing the nerves to slow down or misfire at different times; it can also cause seizures to occur. While it can be detrimental on the nervous system, it is often more detrimental to the developmental systems of the body and the other systems which work to make the body function properly.
In most cases, Down syndrome occurs when there is an extra copy of chromosome 21. This form of Down syndrome is called Trisomy 21. The extra chromosome causes problems with the way the body and brain develop.