When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirmation of the affected tissue (brain biopsy).
There is no disputing it. The oldest hamburger restaurant chain in the United States is White Castle. The first White Castle restaurant opened in Wichita, Kansas, in 1921. The first McDonald's didn't open until 1948, by comparison.
According to the 10-K Annual Report (Filed: Feb 28, 2013), Wendyâs is the worldâs third largest quick-service restaurant company in the hamburger sandwich segment with 4,759 franchised, and 1,427 company-owned U.S. locations as of Dec 30, 2012. Number of U.S. stores open as of Dec 30, 2012: 6,186.