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St. John's Wort (Hypericum perforatum) GENERIC NAME: Hypericum perforatum. BRAND NAME: St. John's Wort. DRUG CLASS AND MECHANISM: St. John's wort is a commonly used over-the-counter (OTC) dietary supplement that is used to treat mild depression, anxiety, and sleep disorders. St. John's wort is a plant that has bright yellow flowers.
Common St. John's-wort (H. perforatum) has long been used in herbalism. It was known to have medical properties in Classical Antiquity and was a standard component of theriacs, from the Mithridate of Aulus Cornelius Celsus ' De Medicina (ca. 30 CE) to the Venice treacle of d'Amsterdammer Apotheek in 1686.ypericum extract, by inducing both the CYP3A4 and the P-glycoprotein (P-gp), can reduce the plasma concentrations of different antineoplastic agents such as imatinib, irinotecan and docetaxel, thus reducing the clinical efficacy of these drugs.