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Extramedullary disease (EMD) occurs when myeloma. cells form tumors outside the bone marrow in the soft. tissues or organs of the body. While myeloma resides mainly within the bone. marrow, EMD can be present at the time of initial. diagnosis or at the time of disease relapse following. treatment-induced remission.
A large study published in the Annals of Oncology in 2009 showed that 85 percent of multiple myeloma patients with extramedullary disease had a tumor in the muscles, tendons, fat, and other soft tissue surrounding the axial skeleton, which includes the skull, rib cage, and vertebral column.he Annals of Oncology study mentioned earlier found that approximately 13 percent of myeloma patients develop extramedullary disease. Specifically, 7 percent of myeloma patients have extramedullary disease at diagnosis, and 6 percent of patients develop the disease during the course of their myeloma.