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Extramedullary disease (EMD) occurs when myeloma. cells form tumors outside the bone marrow in the soft. tissues or organs of the body. While myeloma resides mainly within the bone. marrow, EMD can be present at the time of initial. diagnosis or at the time of disease relapse following. treatment-induced remission.
It occurs in severe or chronic anemias and other diseases that affect blood cell formation. Synonym: myeloid metaplasia. See also: hematopoiesis. extramedullary. situated or occurring outside any of the medullas including the medulla oblongata and the medullary cavities of the bones. extramedullary hematopoiesis. see extramedullary hematopoiesis. the formation of and development of blood cells outside the bone marrow, as in the spleen, liver and lymph nodes. fetal hematopoiesis. in embryogenesis migration of stem cells from the yolk sac blood islands sets up hematopoiesis in thymus, lymph nodes, liver and spleen.