Approximately 30 motor freight companies serve the area. The Virginia Inland Port is located in Front Royal off Interstate 81, just 85 miles north of Waynesboro. The International Port Hampton Roads (185 miles) is the largest natural deep water harbor in the world.
The organic nitrates, including nitroglycerin, isosorbide dinitrate and isosorbide mononitrate, act as prodrugs for nitric oxide (NO) which is a potent vasodilator gas. Nitric oxide activates guanylyl-cyclase in vascular endothelial cells, which increases intracellular cyclic GMP and thereby reduces intracellular calcium concentrates and dephosphorylates myosin light chains causing relaxation of smooth muscle cells.
When we eat nitrates, they are converted into nitrites in our digestive system, which are then converted to ammonia and disposed of by the body. Nitrites are also inorganic compounds made up of nitrogen and oxygen, but instead of three oxygen molecules they have two, NO2. Nitrates are not generally harmful unless they are consumed in massive quantities. Nitrites, on their own and in moderation, are also generally not harmful.