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The median nerve is one of the main nerves in the hand. It originates as a group of nerve roots in the neck. These roots come together to form a single nerve in the arm. The median nerve goes down the arm and forearm, passes through the carpal tunnel at the wrist, and goes into the hand. The nerve provides feeling in the thumb and index, middle, and ring fingers. The nerve also controls the muscles around the base of the thumb.
The sciatic nerve. The sciatic nerve begins in the lumbar (lower back) region of the spine, specifically at the L4 and L5 levels. The nerve exits the spinal canal through two openings in the sacral (pelvic) spine, extending through the length of the legs. The sciatic nerve is the widest nerve of all the millions in the body, and it is also the longest nerve, which means it innervates more areas than any other nerve. Since the sciatic nerve begins in the lower back, but travels all the way to the toes, sciatic nerve pain can extend to the following areas: