In the hepatic 17-ketosteroid pathway of testosterone metabolism, testosterone is converted in the liver by 5Î±-reductase and 5Î²-reductase into 5Î±-DHT and the inactive 5Î²-DHT, respectively. Then, 5Î±-DHT and 5Î²-DHT are converted by 3Î±-HSD into 3Î±,5Î±-androstanediol and 3Î±,5Î²-androstanediol, respectively.
Gardasil is approved for males ages 9 through 26 and Gardasil 9 is approved for use in males ages 9 through 15. The HPV vaccine does not treat or cure an HPV infection in women or men who are already infected by one of these HPV types.PV infection usually causes no symptoms, but can cause genital warts and anal cancer in both women and men. HPV can also cause throat cancer. In women, HPV infection can cause cells in the cervix to grow abnormally. In a small fraction of women, these HPV-induced changes will develop into cervical cancer.
However, high-risk types of HPV also have been linked to less-common cancers of the vulva (3,490 women), vagina (2,140 women), anus (2,750 women and 1,900 men) and penis (1,280 men). Some research also has suggested a link between high-risk types of HPV and other cancers, such as oral (mouth and throat) cancer.