WHAT IS SIMULATION? Computer simulation is the discipline of designing a model of an actual or theoretical physical system, executing the model on a digital computer, and analyzing the execution output.
Efficacy is defined as the maximum effect a drug can produce, regardless of the dose. Potency is related to the amount of drug needed to produce a given effect; it is often quantified by the ED50 or EC50, which are respectively the drug dose or concentration that causes 50% of the maximum effect. Affinity is defined as a drug's ability to bind to a receptor.
-reflects affinity of enzyme for substrate. -small km = tight binding and high affinity. -large km = weak binding and poor affinity. -Km varies for different enzymes (nM to mM) and is often well matched with cellular role -e.g. if substrate concentration is high then Km is high, or if substrate is toxic then Km is low.