Approximately 30 motor freight companies serve the area. The Virginia Inland Port is located in Front Royal off Interstate 81, just 85 miles north of Waynesboro. The International Port Hampton Roads (185 miles) is the largest natural deep water harbor in the world.
The organic nitrates, including nitroglycerin, isosorbide dinitrate and isosorbide mononitrate, act as prodrugs for nitric oxide (NO) which is a potent vasodilator gas. Nitric oxide activates guanylyl-cyclase in vascular endothelial cells, which increases intracellular cyclic GMP and thereby reduces intracellular calcium concentrates and dephosphorylates myosin light chains causing relaxation of smooth muscle cells.
Although nitrates are not directly lethal in the way ammonia or nitrites are, over time high levels of nitrate have a negative effect on fish, plants and the aquarium in general. Although nitrates are not directly lethal in the way ammonia or nitrites are, over time high levels of nitrate have a negative effect on fish, plants and the aquarium in general.