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St. John's Wort (Hypericum perforatum) GENERIC NAME: Hypericum perforatum. BRAND NAME: St. John's Wort. DRUG CLASS AND MECHANISM: St. John's wort is a commonly used over-the-counter (OTC) dietary supplement that is used to treat mild depression, anxiety, and sleep disorders. St. John's wort is a plant that has bright yellow flowers.
Only two of these herbal remedies are supported by sound evidence: Hypericum perforatum (St Johnâs wort) for mild to moderate depression and Piper methysticum (kava) for anxiety. Neither is free of risks. Our knowledge of herbal remedies is incomplete and the subject merits rigorous study.