Photograph by Darlyne A. Murawski, National Geographic. The peanut worm has a proboscis that resembles an elephantâs trunk, as well as a mouth that boasts an impressive array of tentacles. This bottom burrower feeds on organic materials found in mud and sand, and when done feasting it can turn the proboscis inside out to retract it inside its body.
Early clinical development is primarily composed of human proof of principle/pilot clinical studies â to confirm feasibility in human, explore patient populations and performance claims. Concomitantly, subsequent clinical trials are outlined and prepared for.
Staff cost is the biggest driver within the early phase clinical trial category ranging between 40 to 45 percent of the overall cost. The early phase market saw Phase 1 staffing costs rise by 157 percent from 2008 to 2013 as the average number of CRAs assigned to a Phase 1 trial increased.