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Extramedullary disease (EMD) occurs when myeloma. cells form tumors outside the bone marrow in the soft. tissues or organs of the body. While myeloma resides mainly within the bone. marrow, EMD can be present at the time of initial. diagnosis or at the time of disease relapse following. treatment-induced remission.
The extrapyramidal system is a neural network in the central nervous system that helps regulate and modulate motion. It is part of the motor system, along with the pyramidal or corticospinal tract.This network arises from regions in the human brain, such as the pons and medulla, and continues to the spinal cord. Intake of substances or medications can affect the extrapyramidal system, leading to disturbances in motion and balance.he extrapyramidal system indirectly controls motion. It is also referred to as the indirect activation pathway of motor functions. Primarily, the extrapyramidal system is involved in maintaining equilibrium, coordination, posture, muscle tone, and reflexes.