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Liposarcoma is a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the thigh or in the retroperitoneum. Liposarcoma is a rare type of cancer that bears a resemblance to fat cells when examined under a microscope. dedifferentiated liposarcoma has a poorly differentiated component, that is not identifiable as a liposarcoma (left edge of image), and a differentiated component with lipoblasts and increased vascularity (right of image).
1 Well-differentiated liposarcoma is the most common subtype and usually starts as a low grade tumor. Low grade tumor cells look much like normal fat cells under the microscope and tend to grow and change slowly.  Myxoid liposarcoma is an intermediate to high grade tumor.