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Talk to your doctor about this. The same thing happened to me and my doctor increased my zoloft till I was at a dosage that was right for me. It takes about 3 weeks for zoloft to take its full effect. I am now on 150mg and I feel alot better. It is also pretty important to take it at the same time every day. Hope this helps.
Question: I have been taking 50 mg of Zoloft for 2 years for what my doctor termed as situational depression as a result of a death in my immediate family, the ending a 16 year marriage, and my hysterectomy.All of this happened in about a 12 week time period. was taking 10 mg per day Prozac, then a three day rest before starting 25 mg per day Zoloft for one week, then increased to 50 mg per day. My current symptoms are extreme tiredness as I can barely stay awake.