In the hepatic 17-ketosteroid pathway of testosterone metabolism, testosterone is converted in the liver by 5Î±-reductase and 5Î²-reductase into 5Î±-DHT and the inactive 5Î²-DHT, respectively. Then, 5Î±-DHT and 5Î²-DHT are converted by 3Î±-HSD into 3Î±,5Î±-androstanediol and 3Î±,5Î²-androstanediol, respectively.
Gardasil is approved for males ages 9 through 26 and Gardasil 9 is approved for use in males ages 9 through 15. The HPV vaccine does not treat or cure an HPV infection in women or men who are already infected by one of these HPV types.PV infection usually causes no symptoms, but can cause genital warts and anal cancer in both women and men. HPV can also cause throat cancer. In women, HPV infection can cause cells in the cervix to grow abnormally. In a small fraction of women, these HPV-induced changes will develop into cervical cancer.
ACOG (2016) states that major society guidelines currently recommend HPV testing for cervical cancer screening only for women 30 years of age and older, but indicated that use of the cobas HPV test may be considered in women age 25 years and older: In women 25 years and older, the FDA-approved primary HPV screening test can be considered as an alternative to current cytology-based cervical cancer screening methods.