Approximately 30 motor freight companies serve the area. The Virginia Inland Port is located in Front Royal off Interstate 81, just 85 miles north of Waynesboro. The International Port Hampton Roads (185 miles) is the largest natural deep water harbor in the world.
The organic nitrates, including nitroglycerin, isosorbide dinitrate and isosorbide mononitrate, act as prodrugs for nitric oxide (NO) which is a potent vasodilator gas. Nitric oxide activates guanylyl-cyclase in vascular endothelial cells, which increases intracellular cyclic GMP and thereby reduces intracellular calcium concentrates and dephosphorylates myosin light chains causing relaxation of smooth muscle cells.
Break it Down: Ammonia, Nitrites, and Nitrates. Ammonia, nitrites and nitrates are all byproducts of organic waste breaking down in an aquarium, and all are toxic at some level to your fish and plant life. A significant amount of fish and plant waste can accumulate in any aquarium, (as well as uneaten food, algae, and bacteria).