-methyl transferase. Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines.
British Burn Washington, D.C. In 1814, as part of the War of 1812, the British planned to attack the U.S. city of Baltimore, an important city on the Chesapeake Bay. Near Baltimore was Washington, D.C., the nationâs capital since 1800.
Click here.) District of Columbia (Washington, D.C.) is the capital city of the USA. The White House, the Capitol, the Supreme Court, and many other government buildings are located in Washington, D.C. President George Washington chose the site as the future capital of the USA in 1791 (the French architect Pierre Charles L'Enfant designed the city).