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The result: On the days the patients took caffeine, their blood-sugar levels were 8% higher. And after every meal -- including dinner -- their blood sugar spiked higher than it did on the day they had no caffeine. These are clinically significant blood-sugar elevations due to caffeine, Lane tells WebMD. Caffeine increases blood glucose by as much as oral diabetes medications decrease it. ... It seems the detrimental effects of caffeine are as bad as the beneficial effects of oral diabetes drugs are good..
Caffeine stimulates the central nervous system by binding in areas that are reserved for substances that inhibit neuronal firing. This results in a decrease in reaction time and perception of fatigue, and an increase in alertness. Caffeine blocks an enzyme that breaks down cyclic adenosine monophosphate (C-AMP). High levels of C-AMP increase lipolysis, which results in the release of free fatty acids into the blood stream. Muscle cells then absorb the free fatty acids and use them for energy production.