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It uses a synthetic version of the hormone progesterone to achieve these results. Unlike the Pill, your physician will give you a shot, usually in the arm or buttocks. If Depo-Provera shots are received on a recommended basis, pregnancy is highly unlikely.
1 This bone loss is reversible if Depo-Provera is stopped. 2  With Depo-Provera, it is not possible to stop the side effects until the shot wears off, which may take 12 to 14 weeks. 3  If pregnancy is desired, it takes 12 to 18 weeks to get pregnant after the last shot is taken (sometimes longer). This bone loss is reversible if Depo-Provera is stopped. 2  With Depo-Provera, it is not possible to stop the side effects until the shot wears off, which may take 12 to 14 weeks. 3  If pregnancy is desired, it takes 12 to 18 weeks to get pregnant after the last shot is taken (sometimes longer).