Photograph by Darlyne A. Murawski, National Geographic. The peanut worm has a proboscis that resembles an elephantâs trunk, as well as a mouth that boasts an impressive array of tentacles. This bottom burrower feeds on organic materials found in mud and sand, and when done feasting it can turn the proboscis inside out to retract it inside its body.
Early clinical development is primarily composed of human proof of principle/pilot clinical studies â to confirm feasibility in human, explore patient populations and performance claims. Concomitantly, subsequent clinical trials are outlined and prepared for.
PHASES OF CLINICAL TRIALS. Four phases of clinical trials and medicine development exist and are defined below. Each of these definitions is a functional one and the terms are not defined on a strict. chronological basis. An investigational medicine is often evaluated in tow or more. phases simultaneously in different clinical trials.