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Liposarcoma is a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the thigh or in the retroperitoneum. Liposarcoma is a rare type of cancer that bears a resemblance to fat cells when examined under a microscope. dedifferentiated liposarcoma has a poorly differentiated component, that is not identifiable as a liposarcoma (left edge of image), and a differentiated component with lipoblasts and increased vascularity (right of image).
Lipoma vs Atypical Lipomatous Tumor (Well Differentiated Liposarcoma) 1  Diagnosis and behavior depends to a great extent on location. 2  Dermis and subcutis of posterior neck, shoulders and upper back. 3  Virtually all are lipomas.  Most are ordinary lipomas or spindle cell lipomas.