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Estrogen is a necessary hormone in a woman's body, but having symptoms of high estrogen can be uncomfortable - and possibly dangerous. Many women in premenopause (usually beginning around 35 years old) experience the symptoms of excess estrogen: 1. Bloating, weight gain.
Side Effects. Women rarely have severe side effects from taking estrogens to replace estrogen. The prolonged use of estrogens has been reported to increase the risk of endometrial cancer (cancer of the lining of the uterus) in women after menopause. This risk seems to increase as the dose and the length of use increase.