Approximately 30 motor freight companies serve the area. The Virginia Inland Port is located in Front Royal off Interstate 81, just 85 miles north of Waynesboro. The International Port Hampton Roads (185 miles) is the largest natural deep water harbor in the world.
The organic nitrates, including nitroglycerin, isosorbide dinitrate and isosorbide mononitrate, act as prodrugs for nitric oxide (NO) which is a potent vasodilator gas. Nitric oxide activates guanylyl-cyclase in vascular endothelial cells, which increases intracellular cyclic GMP and thereby reduces intracellular calcium concentrates and dephosphorylates myosin light chains causing relaxation of smooth muscle cells.
Eat More Veggies to Boost Your Dietary Nitrates. Nitrate (chemical symbol NO3-) is an inorganic compound composed of nitrogen and oxygen found naturally in soil and water. The nitrate in our diet comes from both food and drinking water, the highest levels of dietary nitrate are found in vegetables. However, the actual amount of nitrate in vegetables can be highly variable depending on growing conditions.