The Livermore Valley rarely experiences severe weather. The greatest annual rainfall during the period between 1931 and 1990 was 1041 mm (41 inches)(NOAA, 1980-1990). During the 5 years between 1986 and 1991, California experienced less than normal precipitation, which is 379 mm (14.9 inches).
Abstract. Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons and control the synthesis, release and uptake of dopamine. These G i/o-coupled inhibitory receptors play a major part in shaping dopamine transmission.2-autoreceptors also regulate dopamine transmission by increasing the activity of DAT (Cass and Gerhardt, 1994, Dickinson et al., 1999, Mayfield and Zahniser, 2001, Schmitz et al., 2002, Wu et al., 2002 and Benoit-Marand et al., 2011).
Neurotransmission can be enhanced acutely by blocking this reuptake with a reuptake inhibitor drug that binds to and blocks the reuptake protein. The ultimate effect of most antidepressants available today is to increase neurotransmitter binding at postsynaptic receptors by increasing levels of available neurotransmitters. Unfortunately, antidepressants also may bind themselves directly to postsynaptic receptors that confer side effects.