WHAT IS SIMULATION? Computer simulation is the discipline of designing a model of an actual or theoretical physical system, executing the model on a digital computer, and analyzing the execution output.
Efficacy is defined as the maximum effect a drug can produce, regardless of the dose. Potency is related to the amount of drug needed to produce a given effect; it is often quantified by the ED50 or EC50, which are respectively the drug dose or concentration that causes 50% of the maximum effect. Affinity is defined as a drug's ability to bind to a receptor.
Potency is determined by both the affinity of the drug for the receptor as well as the number of receptors available for binding. Waldman discusses the relationship between potency and clinical efficacy through evaluation of the in vivo versus in vitro effects of anthistamine agents.