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deterioration, degeneration, decadence, decline mean the falling from a higher to a lower level in quality, character, or vitality. deterioration implies generally the impairment of value or usefulness. the deterioration of the house through neglect; degeneration stresses physical, intellectual, or especially moral retrogression.
Neurodegenerative disease is an umbrella term for a range of conditions which primarily affect the neurons in the human brain. Neurons are the building blocks of the nervous system which includes the brain and spinal cord.