Approximately 30 motor freight companies serve the area. The Virginia Inland Port is located in Front Royal off Interstate 81, just 85 miles north of Waynesboro. The International Port Hampton Roads (185 miles) is the largest natural deep water harbor in the world.
The organic nitrates, including nitroglycerin, isosorbide dinitrate and isosorbide mononitrate, act as prodrugs for nitric oxide (NO) which is a potent vasodilator gas. Nitric oxide activates guanylyl-cyclase in vascular endothelial cells, which increases intracellular cyclic GMP and thereby reduces intracellular calcium concentrates and dephosphorylates myosin light chains causing relaxation of smooth muscle cells.
â¢ Nitrates occur naturally in the soil. â¢ Nitrates are used to preserve cured meats. â¢ Nitrates convert to nitrites in the body. High levels of nitrates have been linked with increased risks of Alzheimer's, diabetes, and Parkinson's, along with gastric, esophageal, and colon cancers. To unlock this lesson you must be a Study.com Member.