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Appendicitis is swelling of the appendix. Typical symptoms are pain in the abdomen, at the McBurney's point, that gradually worsens over several hours. The most common causes of appendicitis are infection and obstruction,
For chronic adrenal insufficiency, the major contributors are autoimmune adrenalitis (Addison's Disease), tuberculosis, AIDS, and metastatic disease. Minor causes of chronic adrenal insufficiency are systemic amyloidosis, fungal infections, hemochromatosis, and sarcoidosis.