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Certain drugs could be the leading cause of memory loss. 1. Anti-depressants: According to Harvard Health Publications, some anti-depressants, as well as tranquilizers can cause memory loss. Paxil is one to avoid.
The following drugs may cause sedation, motor impairment or confusion: 1  Benzodiazepines, tranquilizers like diazepam and lorazepam. 2  Anticholinergics (antispasmodics), such as oxybutynin and glycopyrrolate. 3  Some surgical anesthetics.  Older 1  antidepressants. Certain over-the-counter medications, including diphenhydramine and dimenhydrinate.