Hydrophobic (can't permeate the membrane) substances diffuse throughout the membranes with the assistance of transport protein, either channel protein or carrier protein. Protein with channel opening out -> enter ion -> channel closes-> (if) electrical change outside cell-> protein change shape -> ion exits into cell.
There are 408 calories in 1 cup of Lasagna with Meat. Calorie breakdown: 33% fat, 42% carbs, 24% protein.
If you're looking for a low-calorie meal, you probably want to avoid lasagna. Most versions are loaded with meat and cheese, causing them to be high in both fat and calories. Restaurant versions tend to be among the worst offenders, but some homemade versions can be just as bad.