1 Cover tightly. 2  Preheat oven to 425 degrees F for 15 minutes. 3  Place the roast in the oven and immediately reduce the temperature down to 200 degrees F. 4  Roast for about 4 hours or until the meat is falling-apart tender (cooking time will vary depending on the size of the roast). Place the roast in a greased casserole dish with a lid. 2  Sprinkle the roast on all sides with Worcestershire sauce. 3  Let sit at room temperature for 1-1/2 hours. 4  After 1-1/2 hours spoon any Worcestershire sauce (if any) back on the roast that has accumulated on the bottom of the casserole.
Neonatal sepsis. Neonatal sepsis is a blood infection that occurs in an infant younger than 90 days old. Early-onset sepsis is seen in the first week of life occurs after 1 week and before 3 months of age. Neonatal sepsis can be caused by bacteria such as Escherichia coli (E.coli), Listeria, and some strains of streptococcus. Group B streptococcus (GBS) has been a major cause of neonatal sepsis. However, this problem has become less common because women are screened during pregnancy.
Neonatal sepsis may be categorized as early-onset or late-onset. Of newborns with early-onset sepsis, 85% present within 24 hours, 5% present at 24-48 hours, and a smaller percentage present within 48-72 hours. Onset is most rapid in premature neonates.