Photograph by Darlyne A. Murawski, National Geographic. The peanut worm has a proboscis that resembles an elephantâs trunk, as well as a mouth that boasts an impressive array of tentacles. This bottom burrower feeds on organic materials found in mud and sand, and when done feasting it can turn the proboscis inside out to retract it inside its body.
Early clinical development is primarily composed of human proof of principle/pilot clinical studies â to confirm feasibility in human, explore patient populations and performance claims. Concomitantly, subsequent clinical trials are outlined and prepared for.
Phase I clinical trial. A new research treatment is given to a small number of participants and emphasizes safety. The researchers determine the best way to give the new treatment, find out the drugâs most frequent and serious side effects, and how much of it can be given safely. Phase II clinical trials.