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Low platelet count is also a side effect of disease-modifying drugs, including methotrexate and biologics. Aspirin or other NSAIDs can affect blood clotting, and corticosteroid use causes the capillaries to become fragile and more likely to break and cause a bruise if you bump into something.
I just started taking methotrexate one week ago today and noticed my feet and ankles swelled unlike before. I am taking methotrexate for RA, having just recently been diagnosed. I was wondering too, how long before noticing any good changes in my condition, and if the swelling ankles was just a common side effect.