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Extramedullary disease (EMD) occurs when myeloma. cells form tumors outside the bone marrow in the soft. tissues or organs of the body. While myeloma resides mainly within the bone. marrow, EMD can be present at the time of initial. diagnosis or at the time of disease relapse following. treatment-induced remission.
In anatomy, the extrapyramidal system is a neural network that is part of the motor system causing involuntary movements.The system is called extrapyramidal to distinguish it from the tracts of the motor cortex that reach their targets by traveling through the  pyramids  of the medulla.ll of these regulatory components can be considered part of the extrapyramidal system, in that they modulate motor activity without directly innervating motor neurons. The extrapyramidal tracts include parts of the following: 1  rubrospinal tract.