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Appendicitis is swelling of the appendix. Typical symptoms are pain in the abdomen, at the McBurney's point, that gradually worsens over several hours. The most common causes of appendicitis are infection and obstruction,
Less common causes of primary adrenal insufficiency are chronic infections, mainly fungal infections; cancer cells spreading from other parts of the body to the adrenal glands; amyloidosis; and surgical removal of the adrenal glands. Each of these causes is discussed in more detail below. Secondary Adrenal Insufficiency. This form of Addisons disease can be traced to a lack of ACTH, which causes a drop in the adrenal glands production of cortisol but not aldosterone.