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Runners are sized according to standard lengths. Runners for kitchen cabinet drawers are typically sized in whole numbers running from 18 to 22 inches. The thing to remember is that a smaller drawer will accommodate a longer runner.
Drawer slides come in standard lengths, and the typical base cabinet slide (21 or 22 depending on the manufacturer) will work for the same size drawer whether it is installed inset or overlay. The width (side to side) of the drawer box does not change if the drawers are installed inset.