Best Answer: 1] wash: a] by hand, with fine washables detergent and cold water or. b] on gentle cycle in machine = cold water only. 2] line dry - esp ALL bras [ lining/padding/cups all made of dif materials, that shrink at dif rates; causing permanent lumps and bumps.
If the level of pain increases after dose stabilization, attempt to identify the source of increased pain before increasing the BUTRANS dose. Because steady-state plasma concentrations are achieved within 72 hours, BUTRANS dosage may be adjusted every 3 days. Dose adjustments may be made in 5 mcg/hour, 7.5 mcg/hour, or 10 mcg/hour increments by using no more than two patches of the 5 mcg/hour, or 7.5 mcg/hour, or 10 mcg/hour system(s).
After about five plasma half lives the steady state is achieved. Drugs having longer half lives take longer time to reach the steady state. Drugs having longer half lives have no immediate effect. For the drugs which need to be monitored, first sample is taken after the steady state has been reached. Lithium for bipolar disorder is an example. Plasma levels are maintained by repeated examinations because the drug can be toxic. Its half life is about 24 hours, so the plasma levels are checked after 5 days.