Extinction _____. only happens above the species level cannot happen to more than one species at a time has happened to over 99% of species that ever lived on earth happens when a species or population dies out.
Medical use. Nivolumab is used as a first line treatment for inoperable or metastatic melanoma in combination with ipilimumab if the cancer does not have a mutation in BRAF, and as a second-line treatment for inoperable or metastatic melanoma following treatment of ipilimumab and, if the cancer has a BRAF mutation, a BRAF inhibitor.
Earlier this year, the FDA approved the Bristol-Myers Squibb drug Opdivo (nivolumab) -- which also targets the PD-1/PD-L1 pathway -- to treat squamous non-small cell lung cancer.