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Liposarcoma is a malignant tumor that arises in fat cells in deep soft tissue, such as that inside the thigh or in the retroperitoneum. Liposarcoma is a rare type of cancer that bears a resemblance to fat cells when examined under a microscope. dedifferentiated liposarcoma has a poorly differentiated component, that is not identifiable as a liposarcoma (left edge of image), and a differentiated component with lipoblasts and increased vascularity (right of image).
1 Pleomorphic liposarcoma is the rarest subtype and is a high grade tumor with cells that look very different from normal cells. 2  Dedifferentiated liposarcoma occurs when a low grade tumor changes, and the newer cells in the tumor are high grade.iposarcoma tends to affects adults between the ages of 40 and 60. When it does occur in children, it is usually during the teenage years. There are four types of liposarcoma, each with its own unique characteristics and behaviors.