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Midol is a combination, over-the-counter (OTC) drug used to relieve menstrual symptoms, including cramps and bloating.Combination OTC drugs for menstrual symptoms generally include both a pain reliever and a diuretic -- a medication that relieves bloating by causing your body to release excess fluids.Midol contains acetaminophen as a pain reliever and caffeine as a diuretic.Midol is a brand name medication, though generic equivalents are available as well.ombination OTC drugs for menstrual symptoms generally include both a pain reliever and a diuretic -- a medication that relieves bloating by causing your body to release excess fluids.
Midol is primarily Ibuprofen (Advil). Depending upon the formula, because Midol has several, it may also contain a very mild diuretic to help with the bloating some women get â¦ every month.Some also contain caffeine, which has a mild affect on pain, and the PM version also has some diphenhydramine (benadryl) for sleep.idol is a medicine that is available to buy over-the-counter for  the treatment of menstrual cramps. Midol has caffeine in it and  some forms also have acetaminophen, ibupr â¦ ofen or naproxen sodium in  them. Mr. Andy.