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Runners are sized according to standard lengths. Runners for kitchen cabinet drawers are typically sized in whole numbers running from 18 to 22 inches. The thing to remember is that a smaller drawer will accommodate a longer runner.
Drawers wider than 18 need two knobs/pulls, whereas drawer narrower need only one. If a drawer is wide enough to need two knobs, they should be set about 1/6th of the drawer length from each end (roughly). Single pulls or knobs on drawers should be laterally centered and slightly higher than vertical center.