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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
Ginger. Ginger is used in the treatment of food poisoning and can also help get rid of cramps and abdominal pain. 1  Grate a small piece of ginger and add one teaspoon of honey. 2  Eat the mixture to promote the release of gastric juices and improve digestion.