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Dependency, or addiction, is the most common of long-term heroin effects. Heroin is often considered the most addictive of all legal and illegal substances that are commonly abused for their mind-altering effects.
Long-term health effects. 1  If a person survives the toxic effects of paraquat poisoning, long-term lung damage (scarring) is highly likely. Other long-term effects may also occur, including kidney failure, heart failure, and esophageal strictures (scarring of the swallowing tube that makes it hard for a person to swallow).