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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
The most common side effects from using Synthroid, especially over the long term, are feelings of anxiety, insomnia and muscle tremors. Patients may also experience heart palpitations. These side effects can occur at any time, as the levels of thyroid hormone in the blood fluctuate.he thyroid gland secretes a hormone that regulates metabolism. Because Synthroid works to replace this hormone, long-term use can lead to some of the characteristics of an overactive metabolism.