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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
You may need to try several different ways to stop a muscle cramp before you find what works best for you. Here are some things you can try: 1  Stretch and massage the muscle. 2  Take a warm shower or bath to relax the muscle. 3  A heating pad placed on the muscle can also help. 4  Try using an ice or cold pack.