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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
It is also used for pituitary TSH suppression. Common side effects of Synthroid include fever, hot flashes, sensitivity to heat, sweating, headache, nervousness, irritability, nausea, sleep problems (insomnia), changes in appetite or changes in weight, and transient hair loss.Some women experience menstrual changes.all your doctor at once if you have a serious side effect such as: 1  headache; 2  sleep problems (insomnia); 3  feeling nervous or irritable; 4  fever, hot flashes, sweating; 5  pounding heartbeats or fluttering in your chest; 6  changes in your menstrual periods; or. 7  appetite changes, weight changes.