Nicotinic receptor activation causes the opening of the channel formed by the receptor. This increases the Na+ movement into the target cell, leading to depolarization and generation of the action potential. This rapidly developing change, termed a fast EPSP, is illustrated in Figures 4.3, and 6.2.
And, anecdotally at least, they act as an overall stimulant, producing a titillating, awakening effect and increasing the acuity of the senses. Peppers, especially the hot capsicum (chili) peppers, produce a burning sensation on the skin and mucous membranes, including the inside of the mouth. For the uninitiated, a relatively mild hot pepper can seem intolerably strong and truly hot peppers may even cause blistering of the lips and palate.
Specific short-term effects of LSD, psilocybin, peyote, DMT, and ayahuasca include: LSD. 1  Increased blood pressure, heart rate, and body temperature.2  Dizziness and sleeplessness. 3  Loss of appetite, dry mouth,and sweating.pecific short-term effects of LSD, psilocybin, peyote, DMT, and ayahuasca include: LSD. 1  Increased blood pressure, heart rate, and body temperature.