The cause of irritable bowel syndrome is unknown. Antibiotic-associated colitis usually occurs in people receiving antibiotics. Inflammatory bowel diseases is a common cause of bowel inflammation and low back pain. There are two major forms: Crohns disease and ulcerative colitis. The causes are unknown. â¢Genetic: There is a high similarity of symptoms among identical twins, particularly with Crohn disease.
An effective dose (ED) in pharmacology is the dose or amount of drug that produces a therapeutic response or desired effect in some fraction of the subjects taking it.D50 [edit]. The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). It is also sometimes abbreviated as the ED50, meaning effective dose, for 50% of people receiving the drug.
By Clifford A. Hudis, MD. ABSTRACT: The use of dose-dense therapy is one approach to overcoming the âresistanceâ of malignant cells to adjuvant therapy caused by inadequate drug exposure.In this approach, active drugs are delivered sequentially at their âidealâ dose level separated by short intertreatment intervals.his approach is termed dose-dense therapy because dose intensification is achieved not necessarily or solely through the use of dramatic dose escalation, but rather by means of rapidly recycled treatments.[10]. Clinical Trials.