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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
Common Side Effects of Synthroid. Instances of Synthroid side effects are not particularly common, typically occurring in less than 1 percent of users. The most common of these include change in appetite, diarrhea, headache, leg cramps, and shortness of breath, vomiting or weight loss.ynthroid Side Effects. Synthroid is a synthetic hormone that is used to treat hypothyroidism by replacing the hormones that are not being produced due to a malfunctioning thyroid gland.