Nicotinic receptor activation causes the opening of the channel formed by the receptor. This increases the Na+ movement into the target cell, leading to depolarization and generation of the action potential. This rapidly developing change, termed a fast EPSP, is illustrated in Figures 4.3, and 6.2.
And, anecdotally at least, they act as an overall stimulant, producing a titillating, awakening effect and increasing the acuity of the senses. Peppers, especially the hot capsicum (chili) peppers, produce a burning sensation on the skin and mucous membranes, including the inside of the mouth. For the uninitiated, a relatively mild hot pepper can seem intolerably strong and truly hot peppers may even cause blistering of the lips and palate.
Turmeric Side Effects on Skin and Body. The health benefits of turmeric are plentiful. The yellow spice can soothe your digestive system, it is an effective antiseptics and anti-bacterial agent, it detoxifies the body, it alleviates arthritic pain and breathing problems, and it can prevent heart disease, cancer and Alzheimerâs disease.