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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
1 No, missing one dose will not have much of an effect. 2  I have no thyroid at all and I can skip a dose and have no effect. 3  My dose is 200 mcg. 4  Synthroid has a 1/2 life in your body of about 7 days.5  Meaning it take 7 days for your body to use half the medication. My dose is 200 mcg. 2  Synthroid has a 1/2 life in your body of about 7 days. 3  Meaning it take 7 days for your body to use half the medication. 4  Normally if you forget a dose you should take it asap the same day, but never take a double dose.