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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
To help you cope with your signs and symptoms until the diarrhea goes away, try to: 1  Drink plenty of clear liquids, including water, broths and juices. Avoid caffeine and alcohol. 2  Add semisolid and low-fiber foods gradually as your bowel movements return to normal. Try soda crackers, toast, eggs, rice or chicken.