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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
Research has shown that certain vitamin and nutritional supplements can help lessen menstrual cramps when taken daily. The mechanisms for this are not well understood, but the many dietary supplements have been shown to reduce cramping.