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Skin, mouth, genital symptoms â One characteristic feature of acute HIV infection is open sores or ulcers. These sores or ulcers can develop in the mouth, the esophagus (the tube that extends from the mouth to the stomach), the anus, or the penis. The ulcers are usually painful.
Ulcers that do not heal. A broken area of skin (ulcer) that will not heal can be a symptom of mouth cancer. About 80 out of 100 people (80%) with mouth cancer have this symptom. Pain in your mouth. Pain or discomfort in your mouth that doesn't go away is the other most common symptom of mouth cancer.