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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
As to how long it takes to feel the effects, A week to a month- up to a full 6-12 weeks. Its important to take another blood test in 3 months! Many factors. Your age, activity levels, weight!, etc. Even a brief brisk walk of 5 minutes daily will get the synthroid working faster, feeling the effects on an increased metabolism in just a week to ten days.