The cause of irritable bowel syndrome is unknown. Antibiotic-associated colitis usually occurs in people receiving antibiotics. Inflammatory bowel diseases is a common cause of bowel inflammation and low back pain. There are two major forms: Crohns disease and ulcerative colitis. The causes are unknown. â¢Genetic: There is a high similarity of symptoms among identical twins, particularly with Crohn disease.
An effective dose (ED) in pharmacology is the dose or amount of drug that produces a therapeutic response or desired effect in some fraction of the subjects taking it.D50 [edit]. The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). It is also sometimes abbreviated as the ED50, meaning effective dose, for 50% of people receiving the drug.
The dose-response curve for lacosamide is linear and proportional for oral doses of up to 800 mg and intravenous doses of up to 300 mg. Lacosamide has low potential for drug-drug interactions, and no pharmacokinetic interactions have been found to occur with other (AEDs) that act on sodium channels.ittle of the drug is lost via the first pass effect, and thus has an oral bioavailability of nearly 100%. 40% of the compound remains unchanged from its original structure, while the rest of the elimination product consists of metabolites of lacosamide.