Grahame Hardie, David Carling and Alastair T.R. Sim. The A MP-activated protein kinase is a component of a protein-kinase cascade that. is activated by lipid metabolites, and which has recently been found to regulate. several key enzymes of lipid metabolism.
That said, the key difference between rheumatoid arthritis and osteoarthritis is the cause behind how the joints are affected. Osteoarthritis is a slow and progressive degenerative joint disease, that is, it will slowly develop over years of wear-and-tear on the joints and cartilage.
Gout vs. Osteoarthritis. Gout results from deposits of needle-like crystals of uric acid in connective tissue, joint spaces, or both. These deposits lead to inflammatory arthritis, causing swelling, redness, heat, pain, and stiffness in the joints. On the other hand, Osteoarthritis (OA) is not an autoimmune disease.