Business managers use cost-volume-profit analysis as a way to understand how changes in sales volume, prices and costs will affect profits. Cost refers to fixed and variable costs incurred by the company. Volume refers to the number of products sold. Profit refers to how much money the company makes given the price of the product sold, the volume of products sold and the company's fixed and variable costs.
Glipizide is used to treat type 2 diabetes in people who cannot lower blood sugar sufficiently through lifestyle changes (such as weight loss, diet, and exercise). It works by increasing the production of insulin in the pancreas. It may also help to lower blood sugar by improving insulin resistance.
Sitagliptin is as effective as glipizide at lowering blood sugar levels in patients with type 2 diabetes and chronic kidney disease. Sitagliptin is less likely than glipizide to cause dangerously low blood sugar levels. Patients on sitagliptin tend to lose weight, while those on glipizide gain weight. Some blood-sugar-lowering drugs have caused kidney problems in patients with type 2 diabetes, so physicians are especially cautious when prescribing these agents to diabetics who also have chronic kidney disease (CKD). Previous research indicates that the diabetes drugs sitagliptin and glipizide may not cause considerable kidney damage. New clinical trial results presented during the American Society of Nephrology's Annual Kidney Week compared the two drugs.