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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
You may find it helps with the pain of cramps if you: 1  take the recommended dose of paracetamol. 2  try relaxing in a warm bath. 3  do some gentle exercise, such as walking or swimming. 4  curl up on the sofa with a magazine and a hot water bottle. 5  ask someone to give your lower back a gentle rub.