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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
Tertiary stage syphilis can see damage to the brain, heart, eyes, liver, bones, and joints. This damage may be serious enough to cause death. Other symptoms of the tertiary stage include difficulty with muscle movement, numbness, paralysis, progressive blindness, and dementia.