Nicotinic receptor activation causes the opening of the channel formed by the receptor. This increases the Na+ movement into the target cell, leading to depolarization and generation of the action potential. This rapidly developing change, termed a fast EPSP, is illustrated in Figures 4.3, and 6.2.
And, anecdotally at least, they act as an overall stimulant, producing a titillating, awakening effect and increasing the acuity of the senses. Peppers, especially the hot capsicum (chili) peppers, produce a burning sensation on the skin and mucous membranes, including the inside of the mouth. For the uninitiated, a relatively mild hot pepper can seem intolerably strong and truly hot peppers may even cause blistering of the lips and palate.
The short-term effects of marijuana include problems with memory and learning, distorted perception (sights, sounds, time, touch), trouble with thinking and problem solving, â¦ loss of motor coordination, increased heart rate, and anxiety.or the sake of argument let's take one example of the effects of cocaine on a casual user who takes cocaine a few times a month. Let's also assume that this user takes only enough of the drug to produce a short term high. The immediate affect of snorting coke is an increase of energy and focus.