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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
Usually, it is typical to reduce your Synthroid in order to make room for the Cytomel. Based on my experience, I recommend starting by cutting the 5mcg pill in half with a new, sharp pill cutter. Take one half in the morning with your Synthroid and the other half around 2 in the afternoon.he said to try 1/2 of a 5 mcg tablet of Cytomel on the day I take only 1/2 of the Synthroid which is one day a week now (which she just changed since My TSH was too low).