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Secondary syphilis symptoms may include: 1  Skin rash, usually on the palms of the hands and soles of the feet. 2  Sores called mucous patches in or around the mouth, vagina, or penis.  Moist, warty patches (called condylomata lata) in the genitals or skin folds.
The symptoms of secondary syphilis develop two to eight weeks after a person first becomes infected with primary syphilis. The secondary stage is usually marked by a nonitchy rash. The rash might be confined to one part of your body, or it could spread over several parts. The appearance of the rash varies.