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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
I've started keeping my Synthroid next to my bed at night. I take it when I wake up in the middle of the night, which means I have an empty stomach at the time and also don't have to wait for my coffee in the morning.nVermont, Hoping I can help out (if I understand your confusion correctly). If you take at night, you have to allow enough time after eating for the food to be properly digested thru your stomach (which takes approx. 2 hrs). That's why it doesn't work for me; I like to have a little snack not long before bed.