Several reports demonstrate unexplained consequences of mutations on the expression of the different dystrophin isoforms and their balance. The most prominent example is found in some cases of X-linked dilated cardiomyopathy (XLDC).
In particular, calcitonin has the ability to decrease blood calcium levels at least in part by effects on two well-studied target organs: 1  Bone: Calcitonin suppresses resorption of bone by inhibiting the activity of osteoclasts, a cell type that digests bone matrix, releasing calcium and phosphorus into blood.
Calcitonin. Calcitonin, produced by cells in the thyroid gland, acts directly on osteoclasts (via receptors on the cell surface for calcitonin). The osteoclasts shrink and stop bone resorption. Bone biopsies from patients treated with the drug show no effects on mineralization.It has a short half-life.alcitonin. Calcitonin, produced by cells in the thyroid gland, acts directly on osteoclasts (via receptors on the cell surface for calcitonin). The osteoclasts shrink and stop bone resorption. Bone biopsies from patients treated with the drug show no effects on mineralization. It has a short half-life.