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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
There are many ways to lessen the pain: 1  wear comfortable clothes. 2  stay in a familiar and relaxing place. 3  apply a heating pad or hot water bottle to your lower stomach. 4  use pain medicine like ibuprofen, or codeine.