Nicotinic receptor activation causes the opening of the channel formed by the receptor. This increases the Na+ movement into the target cell, leading to depolarization and generation of the action potential. This rapidly developing change, termed a fast EPSP, is illustrated in Figures 4.3, and 6.2.
Just like red pepper, black pepper has a thermogenic effect when ingested. The spice stimulates your metabolism and thus temporarily increases body heat. A higher basal metabolic rate means higher energy expenditure or more calories burned.
Addiction is One of the Effects of Spice. Despite the fact that a person may see that he is suffering adverse effects from using this drug, he may go back for more, time after time. That is the compulsive, addictive behavior that can result from the use of Spice.arents hope to never see the effects of drug abuse in their children, but the effects of Spice could be particularly terrifying. Spice, or K2, is one of the new synthetics that are popular in many parts of the US.