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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
I was wondering how long it takes before the thyroid medicine starts working. I was diagnosed with Hashi's last week (TSH 65 - under 3 normal, FT4 and T3 under 1, Antibody 600 - normal under 40), and started taking 125 mcg of Synthroid Monday. I know 4 days is probably too early to start working, but I swear I feel worse. I can't sleep much, even though I'm extremely tired.