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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
A Stacy Wiegman, PharmD, Pharmacy, answered. Synthroid should never be used to help you lose weight. Normal doses of Synthroid, which will keep your levothyroxine levels in your body within the normal range, will not cause you to lose any weight.