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2. in oncology, the change that a normal cell undergoes as it becomes malignant. bacterial transformation the exchange of genetic material between strains of bacteria by the transfer of a fragment of naked DNA from a donor cell to a recipient cell, followed by recombination in the recipient chromosome. (trÄnsâ²fÉr-mÄâ²shÉn).
Link to a discussion of cloning genes by transforming E. coli with recombinant DNA molecules. The first demonstration of bacterial transformation was done with Streptococcus pneumoniae and led to the discovery that DNA is the substance of the genes.ransformation. Many bacteria can acquire new genes by taking up DNA molecules (e.g., a plasmid) from their surroundings [ View ]. The ability to deliberately transform the bacterium E. coli has made possible the cloning of many genes â including human genes â and the development of the biotechnology industry.