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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
It takes 6 weeks to have its full effect. You're doctor should have instructed you to come back for blood work at 6 weeks, then your dose can be adjusted if need be. Be patient, adjusting thyroid meds is a delicate process-and it can take 6 months to a year to get it right.I started on Armour about year ago-I felt better after a couple months-but it did nothing for my weight. 09-22-2013, 01:28 PM #3.hyroid meds take around 6 weeks to reach full affect. That does not mean you will see an improvement in metabolism or weight in that time. It can take a some time and meds may need to be adjusted before things improve.