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Doctors don't know exactly what causes eczema. The most common type of eczema -- atopic dermatitis -- resembles an allergy. But the skin irritation, which is more often seen in children rather than adults, is not an allergic reaction. The current thinking is that eczema is caused by a combination of factors that include: Genetics.
1 Burns, if severe enough, can produce blistering. 2  This includes burns from heat, chemicals, and sunburns. 3  Allergic eczema is a skin condition that is caused or worsened by allergens and can produce blisters. 4  Another type of eczema, dyshidrotic eczema, also causes blistering, but its cause is unknown.