In April 1912, Rotary chartered the Winnipeg club marking the first establishment of an American-style service club outside the United States. To reflect the addition of a club outside of the United States, the name was changed to the International Association of Rotary Clubs in 1912.
Subcutaneous tissue is the deepest layer of the skin. It's mostly made up of fat, connective tissue and larger blood vessels and nerves. The thickness of this layer varies throughout the body and form person to person. Subcutaneous tissue is a vital component of body temperature regulation.
The skin (integument) and its derivatives (adnexa) comprise the largest organ in the body. Skin is composed of two layers: (1) the ectodermally derived surface layer called the epidermis and (2) the underlying mesodermally derived connective tissue layer which is called the dermis. The epidermis is a stratified squamous epithelium with a different number of cell layers in different areas of skin.