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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
Synthroid works best if you take it on an empty stomach, one-half to one hour before breakfast. Levothyroxine absorption is increased on an empty stomach. Follow your doctor's dosing instructions and try to take the medicine at the same time each day.