Several reports demonstrate unexplained consequences of mutations on the expression of the different dystrophin isoforms and their balance. The most prominent example is found in some cases of X-linked dilated cardiomyopathy (XLDC).
In particular, calcitonin has the ability to decrease blood calcium levels at least in part by effects on two well-studied target organs: 1  Bone: Calcitonin suppresses resorption of bone by inhibiting the activity of osteoclasts, a cell type that digests bone matrix, releasing calcium and phosphorus into blood.
Troponin is released into the bloodstream 2 to 6 hours after heart cell damage, and blood levels peak in 12 to 26 hours. Elevated levels of troponin are regarded as a more reliable indicator of heart muscle damage than elevated creatine kinase levels.