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Short-Term Effects of Heroin. Often injected, the immediate effects of heroin are to modulate pain perception. As a street drug, dosing is impossible to fully control, and the side effects of decreased heart rate and breathing pose immense risk to users.
In addition to negative short-term effects, long-term crack cocaine abuse can have even more pronounced drawbacks that affect users even when they are not getting high. A short list of the most serious effects includes: 1  Severe depression.