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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
Quinine is the only substance that will get rid of my leg cramps. Iâm talking excruciating pain from the groin down to the feet that can last for hours. If I start to get a cramp, sometimes all it takes are some extra minerals, sometimes a homeopathic, sometimes a glass of tonic water.