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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
1 Some studies suggest getting enough vitamins and minerals â including vitamin B, D, E, magnesium, and zinc â may help ward off the attack of a muscle cramp (or at least help ease the pain) . 2  Jump around. 3  When small nerves in our muscles get fatigued, cramping can occur.