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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
How long should I wait after taking levothyroxine 25 mg to take milk or take my iron pills? Dr. Michael Kleerekoper Dr. Kleerekoper. Levothyroxine: The easiest way would be to take your levothyroxine at bed-time one hour after your last meal or snack. If not you should take your tablet one hour before breakfast.