Nicotinic receptor activation causes the opening of the channel formed by the receptor. This increases the Na+ movement into the target cell, leading to depolarization and generation of the action potential. This rapidly developing change, termed a fast EPSP, is illustrated in Figures 4.3, and 6.2.
And, anecdotally at least, they act as an overall stimulant, producing a titillating, awakening effect and increasing the acuity of the senses. Peppers, especially the hot capsicum (chili) peppers, produce a burning sensation on the skin and mucous membranes, including the inside of the mouth. For the uninitiated, a relatively mild hot pepper can seem intolerably strong and truly hot peppers may even cause blistering of the lips and palate.
Addiction is One of the Effects of Spice. Despite the fact that a person may see that he is suffering adverse effects from using this drug, he may go back for more, time after time. That is the compulsive, addictive behavior that can result from the use of Spice.arents hope to never see the effects of drug abuse in their children, but the effects of Spice could be particularly terrifying. Spice, or K2, is one of the new synthetics that are popular in many parts of the US.