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1 Artificial Sweeteners Artificial sweeteners and sugar alcohols, particularly mannitol and sorbitol, can cause diarrhea in some people. 2  Mannitol and sorbitol linger in the stomach, Schiller says, which can result in bloating and diarrhea.
Medicines That Can Cause Diarrhea. Many prescription and nonprescription medicines can cause diarrhea. A few examples are: Antibiotics. Antidepressants. Antacids. Proton pump inhibitors, such as omeprazole and lansoprazole . Medicines used to treat cancer (chemotherapy). Many antibiotics cause diarrhea. Usually the diarrhea is mild and will clear up without treatment. A more serious type of diarrhea caused by the bacteria Clostridium difficile may occur while taking the antibiotic or shortly after finishing the antibiotic. Diarrhea may be a sign of serious reaction to a medicine, such as a toxic reaction.