Cushing's syndrome, or hypercortisolism, is a relatively rare hormonal disorder caused by prolonged exposure of the body's tissues to high levels of the hormone cortisol. Symptoms include: upper body obesity, rounded face, increased fat around the neck, thinning arms and legs, fatigue, weakness, high blood pressure, and. mood disorders.
In brief: Uniform standered. Pt is prothrombin time, inr is international normalized ratio, both measure cloting tendency in disease and in health. In pt each time you need contol which varies place to place and some what unpredictble. So inr solves the problem by uniform standred all over the world.
International normalized ratio (INR): 0.8-1.1 The warfarin (Coumadin) dose is changed so that the prothrombin time is longer than normal (by about 1.5 to 2.5 times the normal value or INR values 2 to 3). Prothrombin times are also kept at longer times for people with artificial heart valves, because these valves have a high chance of causing clots to form.