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Cowden syndrome is a disorder characterized by multiple noncancerous, tumor-like growths called hamartomas and an increased risk of developing certain cancers. Almost everyone with Cowden syndrome develops hamartomas.
Waardenburg Syndrome. Waardenburg syndrome (WS) is an autosomal dominant disease affecting 1:42,000 births and is characterized by depigmented patches of the skin and hair (partial albinism), blue eyes or heterochromia irides, sensorineural hearing loss, and in some cases spina bifida [135].