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The classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation.Prototype agonists include muscarine and ACh.he classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation. Prototype agonists include muscarine and ACh.
Upon completion of this section, you will be able to: 1  Describe the key ways that muscarinic receptors differ from nicotinic receptors. 2  Describe where muscarinic receptors are found. 3  Identify the key physiological effects that result from stimulation of muscarinic receptors by excessive amounts of acetylcholine.