Raynaud's is a fairly rare disorder of the blood vessels supplying the skin. During a Raynaud's attack, the blood vessels narrow, limiting blood circulation to affected areas. It makes parts of your body (usually fingers, toes, nose and ears) feel numb and cool in cold temperatures or under stress.
PPROM is associated with 30-40% of preterm deliveries and is the leading identifiable cause of preterm delivery. PPROM complicates 3% of all pregnancies and occurs in approximately 150,000 pregnancies yearly in the United States.
In humans, it refers to the abnormal separation after 20 weeks of gestation and prior to birth. It occurs on average in 0.5%, or 1 in 200, deliveries. Placental abruption is a significant contributor to maternal mortality worldwide.