/day, 10 mg/day, 15 mg/day and 20 mg/day, the efficacy of Trintellix for the acute treatment of MDD was demonstrated in at least one of the clinical studies as measured by improvement in the primary efficacy endpoint.
Hydrogen bonding is important in many chemical processes. Hydrogen bonding is responsible for water's unique solvent capabilities. Hydrogen bonds hold complementary strands of DNA together, and they are responsible for determining the three-dimensional structure of folded proteins including enzymes and antibodies. simple way to explain hydrogen bonds is with water. The water molecule consists of two hydrogens covalently bound to an oxygen. Since oxygen is more electronegative than hydrogen, oxygen pulls the shared electrons more closely to itself.
These combinations (A/T) and (G/C) are called base pairs. The two DNA strands are held together by interchain hydrogen bonds. H-bonds pair the bases in one chain to the complementary bases in the other chain. (A/T and G/C). slide 2 of 4. Hydrogen Bonds in DNA A number factors are responsible for the stability of the DNA double helix structure, among them hydrogen bonds. Internal and external hydrogen bonds stabilize the DNA molecule. The two strands of DNA stay together by H bonds that occur between complementary nucleotide base pairs. Two hydrogen bonds occur between the adenosine and the thymine base pairs, and between the cytosine and the guanine there are three. While each hydrogen bond is extremely weak (compared to a covalent bond for example), the millions of H-bonds together represent an extremely strong force that keeps the two DNA strands together. In addition, other groups of the base rings (polar groups) can form external hydrogen bonds with surrounding water that give the molecule extra stability.