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Anatomy and Physiology. Internal derangement of the knee is a mechanical disorder of the knee which interferes with normal joint motion and/or mobility. A fragment of soft tissue or bone that suddenly becomes interposed between the articular surfaces is the classic cause of internal derangement.natomy and Physiology. Internal derangement of the knee is a mechanical disorder of the knee which interferes with normal joint motion and/or mobility. A fragment of soft tissue or bone that suddenly becomes interposed between the articular surfaces is the classic cause of internal derangement.
Dislocated kneecap: The kneecap slides out of position, causing knee pain and swelling. IT (iliotibial) band syndrome: The iliotibial (IT) band is a piece of tough tissue that runs from your hip down to the outer part of your knee. When you overdo activity, it can become inflamed over time. That causes pain on the outer side of the knee and is common in runners when going downhill. Loose cartilage: Sometimes, a knee injury can break loose cartilage. These pieces can get stuck in the joint, which causes pain and swelling.