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When Milan was the capital of the west, it surpassed Rome in importance because the imperial court was there. Christianity was made the state religion of the empire with the Edict of Milan. Two fathers of the Catholic church worked in Milan.
Though Rome and Constantinople were the centers of the so-called 'Orthodox Christianity', many Christian groups particularly in Mesopotamia opposed their policies and doctrines. In 410, a meeting of Christians was held at the Persian capital under the presidency of Mar Isaac, the bishop of Ctesiphon.