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If you eat a diet of rich, fatty foods, they may pass through your system more rapidly and give you diarrhea. 1  Artificial Sweeteners Artificial sweeteners and sugar alcohols, particularly mannitol and sorbitol, can cause diarrhea in some people. Mannitol and sorbitol linger in the stomach, Schiller says, which can result in bloating and diarrhea.
Medicines That Can Cause Diarrhea. Many prescription and nonprescription medicines can cause diarrhea. A few examples are: Antibiotics. Antidepressants. Antacids. Proton pump inhibitors, such as omeprazole and lansoprazole . Medicines used to treat cancer (chemotherapy). Many antibiotics cause diarrhea. Usually the diarrhea is mild and will clear up without treatment. A more serious type of diarrhea caused by the bacteria Clostridium difficile may occur while taking the antibiotic or shortly after finishing the antibiotic. Diarrhea may be a sign of serious reaction to a medicine, such as a toxic reaction.