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The largest metropolitan areas remain 1) New York, 2) Los Angeles, 3) Chicago, 4) Washington D.C., and 5) Boston.
Detroit, Cleveland, Toledo lead U.S. in population loss; San Jose now among 10 cities above 1 million. 10 largest U.S. cities. New York, Los Angeles and Chicago still lead the list of the 10 largest cities in the United States, according to new estimates for 2014 from the Census Bureau.