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Caffeine withdrawal symptoms typically appear 12 to 24 hours after abstaining from coffee, and peak within 24 to 48 hours. They include: headache; lethargy and drowsiness; depressed mood; anxiety; nausea; vomiting; muscle pain and stiffness; and inability to concentrate.
Regular ingestion of the drug alters your brain's chemical makeup, leading to fatigue, headaches and nausea if you try to quit. Regular caffeine use alters your brainâs chemical makeup, leading to fatigue, headaches and nausea if you try to quit. Within 24 hours of quitting the drug, your withdrawal symptoms begin. Initially, theyâre subtle: The first thing you notice is that you feel mentally foggy, and lack alertness.