Periodontal Ehlers-Danlos syndrome Periodontal EDS (pEDS) causes dental problems, particularly inflamed or absent gums and poor tooth development, on top of typical features of cEDS. It is rare but can be inherited from one parent only, as only one faulty gene is needed to develop the condition.
Ribs 1, 2, 11 and 12 can be describes as âatypicalâ â they have features that are not common to all the ribs. Rib 1 is shorter and wider than the other ribs. It only has one facet on its head for articulation with its corresponding vertebrae (there isnât a thoracic vertebrae above it).
Specifically, CD patients who carry NOD2 mutations are more likely to require small bowel surgery, and there is evidence of a gene-dose effect: NOD2 homozygotes, on average, require surgery sooner than do heterozygotes, who, in turn, require surgery earlier than do wild-type homozygotes.OD2 mutations are associated with small bowel CD and, in some studies, with stricturing disease. This anatomical association negates the use of NOD2 in distinguishing CD from ulcerative colitis, as further diagnostic tests are not needed to distinguish small bowel from colonic inflammation.