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The largest metropolitan areas remain 1) New York, 2) Los Angeles, 3) Chicago, 4) Washington D.C., and 5) Boston.
Almost all of manhattan is a downtown. Midtown is the largest CBD in the US. Downtown Manhattn is the third largest due to the loss of the WTC but it will regain 2nd after we finish rebuilding. So add that with midtown thats one big downtown. Not to mention all the neighborhoods in between midtown and downtown manhattan.