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Equally important and coupled with DNA methylation is DNA demethylation, the removal of a methyl group. The demethylation process is necessary for epigenetic reprogramming of genes and is also directly involved in many important disease mechanisms such as tumor progression.
DNA ligase is an enzyme which seals gaps in the sugar-phosphate backbone of DNA molecules. This is necessary in the replication of DNA as the lagging strand is synthesised i â¦ n short fragments by DNA polymerase. The gaps between the fragments are then sealed by DNA ligase.