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The classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation.Prototype agonists include muscarine and ACh.he classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation. Prototype agonists include muscarine and ACh.
The master circadian pacemaker in mammals is located in the suprachiasmatic nucleus in the rostroventral hypotha-lamus (Figure 2). Lesion studies identified it in 1972, and in vitro and in vivo functional studies, as well as transplant studies, have repeatedly corroborated the finding since then.