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Anatomy and Physiology. Internal derangement of the knee is a mechanical disorder of the knee which interferes with normal joint motion and/or mobility. A fragment of soft tissue or bone that suddenly becomes interposed between the articular surfaces is the classic cause of internal derangement.natomy and Physiology. Internal derangement of the knee is a mechanical disorder of the knee which interferes with normal joint motion and/or mobility. A fragment of soft tissue or bone that suddenly becomes interposed between the articular surfaces is the classic cause of internal derangement.
1 If the area isnât numbed properly the injection can be painful. 2  Doctors typically only allow three injections a year since long term and repeated use can cause bone loss, weakening of tendons, and cartilage loss in the knee joint.3  Infections are also possible since the needle is injected into the joint.ortisone knee injections are very effective at temporarily relieving swelling and inflammation. The Downside To Cortisone Injections: 1  Cortisone injections for knee pain will be ineffective if there is no swelling or inflammation in the knee. 2  If the area isnât numbed properly the injection can be painful.