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Pronator quadratus is a square shaped muscle on the distal forearm that acts to pronate (turn so the palm faces downwards) the hand. As it is on the anterior side of the arm, it is innervated by a branch of the median nerve, the anterior interosseous nerve (roots C8 and T1 with T1 being primary).
Even though pain caused by the pronator quadratus is felt in the wrist and thumb areas it is important that you treat the muscle itself for pain relief. The Elite-Kold Wrist and Elbow Ice Wrap is a good choice for this pain. I like this wrap because it can be used for the elbow and forearm.