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A full set of sister chromatids is created during the S subphase of interphase, when all the DNA in a cell is replicated. Identical chromosome pairs are separated into two different cells during mitosis, or cellular division.
In general, sister chromatids are either of the two chromatids of the same chromosome joined together by a common centromere. Once sister chromatids have separated (during the anaphase of mitosis or the anaphase II of meiosis during sexual reproduction), the strands are called daughter chromosomes. non-sister chromatid, on the other hand, refers to either of the two chromatids of paired homologous chromosomes, that is, the pairing of a paternal chromosome and a maternal chromosome. Non-sister (homologous) chromatids form chiasmata to exchange genetic material during the prophase I of meiosis.