In humans (n = 10) infused with 1.0â1.3 mmol sodium dl-lactate/(kg Â· h), â¼90% of d-lactate was metabolized, and 10% excreted in the urine (12). At higher infusion rates of 3.0â4.6 mmol/(kg Â· h), metabolism decreased to â¼75% of overall clearance (12).
Deaths from alcohol poisoning as a contributing cause peaked for those between ages 35 and 44 (average age at death was 39.9 years). When the age-specific rate was calculated using deaths with any mention of alcohol poisoning, the rate was highest at ages 35 to 44 (1.33 deaths per 100,000 population).
Nationwide, the age-adjusted death rate for unintentional drug poisoning increased from 4.0 deaths in 1999 to 9.7 deaths per 100,000 U.S. population in 2010. Unintentional poisoning deaths in Michigan involving opioids comprise 20% of unintentional poisoning deaths in 2012, compared to 11% in 1999.