Furthermore, the protestant John Knox and Mary of Guise's half-brother James Stuart were stirring Scotland up against the Church of Rome, a situation which the King of France could not allow to continue. Thus Henry I gave his consent and the public marriage document was signed on 19th April 1558.
Critical Limb Ischemia (CLI) Critical Limb Ischemia (CLI) is a severe obstruction of the arteries which markedly reduces blood flow to the extremities (hands, feet and legs) and has progressed to the point of severe pain and even skin ulcers or sores. The pain caused by CLI can wake up an individual at night.
Ischemia is the medical term for what happens when your heart muscle doesn't get enough oxygen. Ischemia usually happens because of a shortage of blood and oxygen to the heart muscle. It is usually caused by a narrowing or blockage of one or more of the coronary arteries (which supply blood to the heart muscle). In many cases ischemia is a temporary problem.