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The classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation.Prototype agonists include muscarine and ACh.he classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation. Prototype agonists include muscarine and ACh.
Muscarinic receptor activation of postsynaptic cells can be either excitatory or inhibitory and is always slow in onset and long in duration (Table I). Figure 11.16 and Figure 11.17 illustrate an excitatory and an inhibitory postsynaptic potential in the sympathetic ganglion.