Furthermore, the protestant John Knox and Mary of Guise's half-brother James Stuart were stirring Scotland up against the Church of Rome, a situation which the King of France could not allow to continue. Thus Henry I gave his consent and the public marriage document was signed on 19th April 1558.
Critical Limb Ischemia (CLI) Critical Limb Ischemia (CLI) is a severe obstruction of the arteries which markedly reduces blood flow to the extremities (hands, feet and legs) and has progressed to the point of severe pain and even skin ulcers or sores. The pain caused by CLI can wake up an individual at night.
Ischemia is the condition or state in which a tissue such as brain is subjected to hypoxia or low oxygen because of an obstruction of the arterial blood supply or inadequate blood flow. Brain ischemia can be broadly divided into two main classifications, global ischemia and focal ischemia. Global ischemia is the condition or state in which blood flow to the entire brain is transiently blocked, which results in delayed, selective neuronal death.