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A larger peak in activity at around 6 hours is usually associated with a shorter action time, and vice versa. Anyone who does not take their long-acting insulin at about the same time each day can also experience gaps and stacking of insulin with a single injection a day. Smaller doses are also often associated with greater insulin activity at 6 hours with less at 18 hours and beyond.
1 This type of insulin is used with longer-acting insulin. 2  Short-acting: Usually taken about 30 minutes before a meal to cover the blood glucose elevation from eating. 3  This type of insulin is used with longer-acting insulin.4  Intermediate-acting: Covers the blood glucose elevations when rapid-acting insulins stop working. This type of insulin is often combined with rapid-or short-acting insulin and is usually taken twice a day. 2  Long-acting: This type of insulin is often combined, when needed, with rapid-or short-acting insulin. 3  It lowers blood glucose levels when rapid-acting insulins stop working. 4  It is taken once or twice a day.