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The pericardium (from the Greek ÏÎµÏÎ¯, around and ÎºÎ¬ÏÎ´Î¹Î¿Î½, heart) is a double-walled sac containing the heart and the roots of the great vessels. The pericardial sac has two layers, a serous layer and a fibrous layer. It encloses the pericardial cavity which contains pericardial fluid. The pericardium fixes the heart to the mediastinum, gives protection against infection, and provides the lubrication for the heart.
The pericardium is a mesothelium tissue of the thoracic cavity which surrounds the heart. The outer layer, the fibrous pericardium, is comprised of dense connective tissue that protects the heart, anchors it to the surrounding walls, and prevents it from overfilling.