Taxonomic Notes: While subspecies taxonomy of Elephas maximus has varied among authors, the most recent treatment (Shoshani and Eisenberg 1982) recognizes three subspecies: E. m. indicus on the Asian mainland, E. m. maximus on Sri Lanka, and E. m. sumatranus on the Indonesian island of Sumatra.
How Does It Work? Avapro is part of a class of drugs called angiotensin II receptor blockers. As the name implies, the drug blocks angiotensin II receptors. This decreases the effectiveness of a chemical known as angiotensin II, which normally causes blood vessels to narrow (constrict).
Irbesartan, in a study at a dose of up to 4.5 mg/kg/day, once daily, did not appear to lower. blood pressure effectively in pediatric patients ages 6 to 16 years. AVAPRO has not been studied in pediatric patients less than 6 years old.