Leroy Satchel Paige was the longtime Negro League star who eventually received his due in the majors. He reportedly got his nickname working as a baggage porter in Mobile, Ala., where he became a satchel tree by carrying several bags at once. Satchel, the man, was literally ageless.
The diagnosis of AML requires the identification of 20% or more leukemic blasts in the bone marrow. Further analysis then must separate AML from acute lymphoblastic leukemia by showing evidence for commitment to the myeloid lineage.
Approximately 40â45% of patients with de novo AML have normal cytogenetics. Progress in the molecular characterization of AML has largely focused on this group of patients, and the findings show that the majority of CN-AML patients now have a detectable recurrent genetic mutation (Table 1).