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The classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation.Prototype agonists include muscarine and ACh.he classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation. Prototype agonists include muscarine and ACh.
A muscarinic receptor agonist is an agent that activates the activity of the muscarinic acetylcholine receptor.The muscarinic receptor has different subtypes, labelled M1-M5, allowing for further differentiation. Cevimeline (AF102B) (Evoxac) is a muscarinic agonist that is an Food and Drug Administration (FDA)- approved drug and used for the management of dry mouth in Sjoegren'sjÃ¶gren s.  syndrome