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A larger peak in activity at around 6 hours is usually associated with a shorter action time, and vice versa. Anyone who does not take their long-acting insulin at about the same time each day can also experience gaps and stacking of insulin with a single injection a day. Smaller doses are also often associated with greater insulin activity at 6 hours with less at 18 hours and beyond.
I've been taking two diffeent types of insulin (fast acting and a 24 hr. type that levels me out for a 24 hour period) for at least 8-10 years. I recently found that not only had I gained weight but my insulin use increased substantially (daily fast acting up to 70 units; evening insulin up at 62 units).