1 For example, the disorder sickle cell anaemia is caused by a mutation in the gene that instructs the building of a protein called haemoglobin. 2  This causes the red blood cells to become an abnormal, rigid, sickle shape. 3  However, in African populations, having this mutation also protects against malaria.
Optimistic time - generally the shortest time in which the activity can be completed. It is common practice to specify optimistic times to be three standard deviations from the mean so that there is approximately a 1% chance that the activity will be completed within the optimistic time.
The answer often is due to a phenomena known as Merge Bias, or Nodal Bias, and is a feature that has no equivalent in Cost Risk analysis. It is unique to schedules due to the logical relationships between activities.xample. Consider the following example of a single activity driving a completion milestone, the activity (and whole project) most likely duration is 100days, there is minimum duration of 80days, and a maximum of 120 days.