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Caffeine withdrawal symptoms typically appear 12 to 24 hours after abstaining from coffee, and peak within 24 to 48 hours. They include: headache; lethargy and drowsiness; depressed mood; anxiety; nausea; vomiting; muscle pain and stiffness; and inability to concentrate.
Later opiate withdrawal symptoms include: 1  Abdominal cramps. 2  Diarrhea. 3  Loss of appetite or a desire to eat but an inability to keep food down.  Dilated 1  pupils. Goose bumps, fever or cold sweats. 2  Nausea. Vomiting.  Increased 1  irritability. Continued insomnia.