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When Milan was the capital of the west, it surpassed Rome in importance because the imperial court was there. Christianity was made the state religion of the empire with the Edict of Milan. Two fathers of the Catholic church worked in Milan.
This city was the capital of the Eastern Roman Empire, a center of trade, and eventually renamed Constantinople. This city, founded by the Roman Emperor Constantine in 330 AD, is located between the Mediterranean and Black seas. Constantine transferred the center of the imperial government there, from Rome.