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Symptoms of Local anaesthetic allergy. Click to Check. Skin rash - localized or widespread. Sun-sensitive skin - occurs within a week or two of taking the medicine. Aching joints - occurs within a week or two of taking the medicine. Aching muscles - occurs within a week or two of taking the medicine.
Regional Anesthesia. The potential side effects of regional anesthesia (such as an epidural or spinal block, in which an anesthetic is injected in the lower back), include: 1  Headache â This can occur a few days after the procedure if some of the spinal fluid leaks out.erious but rare complications include: 1  Pneumothorax â When anesthesia is injected near the lungs, the needle may accidentally enter the lung. 2  This could cause the lung to collapse and require a chest tube to be inserted. 3  Nerve damage â Although very rare, nerve damage can occur, causing temporary or permanent pain.