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Anatomy and Physiology. Internal derangement of the knee is a mechanical disorder of the knee which interferes with normal joint motion and/or mobility. A fragment of soft tissue or bone that suddenly becomes interposed between the articular surfaces is the classic cause of internal derangement.natomy and Physiology. Internal derangement of the knee is a mechanical disorder of the knee which interferes with normal joint motion and/or mobility. A fragment of soft tissue or bone that suddenly becomes interposed between the articular surfaces is the classic cause of internal derangement.
knee-pain. 1  Nerve impingement at L5-S1 can cause pain in the knees, although a clinical exam is needed to make an accurate diagnosis. Other causes of referred knee pain are injury to the hip joint and damage to the ligaments and meniscus at the knee joint. Joint fusion may alleviate your symptoms.