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Here is my reply to Terra20: 1. Sodium Hydroxymethylglycinate is a naturally derived preservative that is effective in both hydrophobic and hydrophilic solutions to prevent the growth of bacteria and microbes.2. It is an inert salt that has one of the lowest reaction rates of any preservative used in cosmetics.lso, I was asked what my opinion is regarding this ingredient. Here is my reply to Terra20: 1. Sodium Hydroxymethylglycinate is a naturally derived preservative that is effective in both hydrophobic and hydrophilic solutions to prevent the growth of bacteria and microbes. 2.