Akt Signaling. Akt (v-Akt Murine Thymoma Viral Oncogene)/ PKB (Protein Kinase-B) is a Serine/threonine Kinase that is involved in mediating various biological responses, such as inhibition of Apoptosis and stimulation of cell proliferation. Three mammalian isoforms are currently known: Akt1/PKB- Alpha, Akt2/PKB-Beta and Akt3/PKB-Gamma.
Vascular: Relating to blood vessels. For example, the vascular system in the body includes all of the veins and arteries. And, a vascular surgeon is an expert at evaluating and treating problems of the veins and arteries.
Medical Definition of CIRCULATION. : the movement of blood through the vessels of the body that is induced by the pumping action of the heart and serves to distribute nutrients and oxygen to and remove waste products from all parts of the bodyâsee pulmonary circulation, systemic circulation. the movement of blood through the vessels of the body that is induced by the pumping action of the heart and serves to distribute nutrients and oxygen to and remove waste products from all parts of the bodyâsee pulmonary circulation, systemic circulation.