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The classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation.Prototype agonists include muscarine and ACh.he classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation. Prototype agonists include muscarine and ACh.
Nicotinic receptors are all excitatory, but muscarinic receptors can be both excitatory and inhibitory depending on the subtype. They also differ on where they are found in the body (i.e. sympathetic vs parasympathetic nervous system). [1] Acetylcholine receptors: muscarinic and nicotinic. [2] Page on ebi.ac.uk.