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The classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation.Prototype agonists include muscarine and ACh.he classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation. Prototype agonists include muscarine and ACh.
Page 7.Lipid-soluble Hormones The lipid-soluble hormones are steroids and TH. Receptors are located inside cells, typically inside the nucleus. Each receptor has a site that binds to the hormone and a site that binds to DNA. The DNA site is covered by a chaperone molecule when no hormone is present.