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When Milan was the capital of the west, it surpassed Rome in importance because the imperial court was there. Christianity was made the state religion of the empire with the Edict of Milan. Two fathers of the Catholic church worked in Milan.
As a result, Italy sat at the crossroads of the Western and Eastern trade routes. The city of Rome, now one tenth its size in the Pax Romana was headquarters of the Roman Catholic Church following the Babylonian Captivity. The church was the single unifying entity throughout the continent.