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Caffeine withdrawal symptoms typically appear 12 to 24 hours after abstaining from coffee, and peak within 24 to 48 hours. They include: headache; lethargy and drowsiness; depressed mood; anxiety; nausea; vomiting; muscle pain and stiffness; and inability to concentrate.
Potential Side Effects of Coffee Enemas. Coffee enemas, however beneficial as they may be, also have side effects. Adverse reactions may include intestinal cramping, loss of appetite, fever, electrolyte imbalance, and diarrhea. These consequences can further lead to dehydration, constipation, and infection.