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Caffeine withdrawal symptoms typically appear 12 to 24 hours after abstaining from coffee, and peak within 24 to 48 hours. They include: headache; lethargy and drowsiness; depressed mood; anxiety; nausea; vomiting; muscle pain and stiffness; and inability to concentrate.
Caffeine is considered to be the most commonly used psychoactive drug in the world. Coffee, soda, and tea are the most common sources of caffeine in the American diet. Discontinuation of regular caffeine use may produce withdrawal symptoms. The effects of caffeine persist for about three hours or less. Caffeine is found in some combination medications and weight control products.