Combined factor V and factor VIII deficiency is an inherited bleeding disorder that is caused by low levels of factors V and VIII. Because the amount of these factors in the body is lower than normal, the clotting reaction is blocked prematurely and the blood clot does not form.The combined deficiency is completely separate from factor V deficiency and factor VIII deficiency (hemophilia A).ymptoms. The combination of factor V and factor VIII deficiency does not seem to cause more bleeding than if only one or the other of the factors were affected. The symptoms of combined factor V and factor VIII deficiency are generally mild. See Bleeding Symptoms of Rare Clotting Factor Deficiencies.
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