Leroy Satchel Paige was the longtime Negro League star who eventually received his due in the majors. He reportedly got his nickname working as a baggage porter in Mobile, Ala., where he became a satchel tree by carrying several bags at once. Satchel, the man, was literally ageless.
The diagnosis of AML requires the identification of 20% or more leukemic blasts in the bone marrow. Further analysis then must separate AML from acute lymphoblastic leukemia by showing evidence for commitment to the myeloid lineage.
AML results from the clonal expansion of myeloid blasts in the peripheral blood, bone marrow or other tissue. It is caused when either the myeloid stem cells produce abnormal myeloblasts which do not become healthy white blood cells or too many myeloid stem cells become abnormal red blood cells or platelets.