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The classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation.Prototype agonists include muscarine and ACh.he classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation. Prototype agonists include muscarine and ACh.
Initially, on the basis of pharmacological selective affinity to the muscarinic agonist pirenzepine, two subtypes of muscarinic receptors, M 1 R and M 2 R, were described (61). In 1987, using molecular cloning techniques, Bonner et al. (14) described five muscarinic receptor subtypes (M 1 RâM 5 R).nitially, on the basis of pharmacological selective affinity to the muscarinic agonist pirenzepine, two subtypes of muscarinic receptors, M 1 R and M 2 R, were described (61). In 1987, using molecular cloning techniques, Bonner et al. (14) described five muscarinic receptor subtypes (M 1 RâM 5 R).