Furthermore, the protestant John Knox and Mary of Guise's half-brother James Stuart were stirring Scotland up against the Church of Rome, a situation which the King of France could not allow to continue. Thus Henry I gave his consent and the public marriage document was signed on 19th April 1558.
Critical Limb Ischemia (CLI) Critical Limb Ischemia (CLI) is a severe obstruction of the arteries which markedly reduces blood flow to the extremities (hands, feet and legs) and has progressed to the point of severe pain and even skin ulcers or sores. The pain caused by CLI can wake up an individual at night.
Focal ischemia or cerebral infarction is the condition or state in which a specific area of brain tissue undergoes injury as a consequence of a temporary or permanent obstruction of local blood supply. Focal ischemia results in death of both neurons and nonneuronal cells in contiguous areas of brain, usually representing a single vascular territory.