/day, 10 mg/day, 15 mg/day and 20 mg/day, the efficacy of Trintellix for the acute treatment of MDD was demonstrated in at least one of the clinical studies as measured by improvement in the primary efficacy endpoint.
Hydrogen bonding is important in many chemical processes. Hydrogen bonding is responsible for water's unique solvent capabilities. Hydrogen bonds hold complementary strands of DNA together, and they are responsible for determining the three-dimensional structure of folded proteins including enzymes and antibodies. simple way to explain hydrogen bonds is with water. The water molecule consists of two hydrogens covalently bound to an oxygen. Since oxygen is more electronegative than hydrogen, oxygen pulls the shared electrons more closely to itself.
See Fig. 1. The nucleotides within each strand are held together by the phosphodiester bonds between the 5' carbon of one nucleotide and the 3 ' carbon of the adjacent nucleotdie. These strong covalent bonds form the the glue that holds the sugar/phosphate backbone together and thus act to keep each strand together.The two strands of DNA are held together by weak hydrogen bonds (remember, something must hold them together!) between the nitrogenous bases.The interesting (and very important) aspect of the Watson-Crick model is that these hydrogen bonds are base specific.he two strands of DNA are held together by weak hydrogen bonds (remember, something must hold them together!) between the nitrogenous bases. The interesting (and very important) aspect of the Watson-Crick model is that these hydrogen bonds are base specific.