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Causes of Pyogenic Granuloma. A pyogenic granuloma often occurs in areas of previous trauma including acne cysts. It is believed that this lesion is formed when capillary blood vessels start growing rapidly in response to trauma to the skin. These growths mostly occur after injuries, but the reason for this isnât known.
Multi-system sarcoidosis is not caused by any element, but granulomatous disease of the lung and skin may be caused by beryllium. The disease is called berylliosis. Zirconium (used in deodorants) can cause granulomas in the skin, but it does not cause not systemic sarcoidosis. 35.