Visceral pain is often described as generalized aching or squeezing. It is caused by compression in and around the organs, or by stretching of the abdominal cavity. Sometimes visceral pain may radiate to other areas in the body, making it even harder to pinpoint its exact location.
Data from the largest analysis to date of amyloid plaques showed they can appear 20 or 30 years before dementia symptoms.
Both types of amyloidosis contain amyloid P component, a non-fibrillary glycoprotein found in the circulation; scintigraphy after injection of 123I-labelled serum amyloid P component can locate tissue deposition of amyloidosis and, if the deposition is active, cytotoxic therapy may be instituted; focal amyloidosis commonly occurs in those organs most susceptible to ageing (e.g., the heart and brain), and is only symptomatic if the amyloid deposition is significant.