Template:Aquatic layer topics. An abyssal plain is an underwater plain on the deep ocean floor, usually found at depths between 3000 and 6000 m. Lying generally between the foot of a continental rise and a mid-ocean ridge, abyssal plains cover more than 50% of the Earth âs surface.
Murad discovered in 1977 that nitroglycerin and related artery-widening compounds act by releasing nitric oxide. Furchgott later concluded that cells in the inner lining of blood vessels secrete some unknown substance that makes vessels dilate.
A scheme of the shear stress-induced EDRF-NO mechanism. Nitric oxide (NO) is of critical importance as a mediator of vasodilation in blood vessels. It is induced by several factors, and once synthesized by eNOS it results in phosphorylation of several proteins that cause smooth muscle relaxation.