During Larry Nassar's sexual abuse trial and sentencing, victims' harrowing stories have brought to light Ehlers-Danlos Syndrome (EDS), a condition that is common among gymnasts, but poorly understood.
A mechanism by which different forms of mature mRNAs are generated from the same gene. Alternative splicing is a regulatory mechanism by which variations in the incorporation of the exons, or coding regions, into mRNA leads to the production of more than one related protein, or isoform. RNA interference.
Antisense oligonucleotides are designed to do precisely this job. They hybridize to specific mRNAs and inhibit expression of particular proteins. Figure 1 | Mechanism of antisense oligonucleotidesSchematic representation of RNase H-mediated destruction of mRNA in the presence of an antisense oligonucleotide.