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Causes of Pyogenic Granuloma. A pyogenic granuloma often occurs in areas of previous trauma including acne cysts. It is believed that this lesion is formed when capillary blood vessels start growing rapidly in response to trauma to the skin. These growths mostly occur after injuries, but the reason for this isnât known.
Granulomas can also be caused by other infections, including coccidiomycosis and cryptococcosis. Pulmonary nodules can be caused by noninfectious conditions such as Wegener's granulomatosis, rheumatoid arthritis and sarcoidosis. Neoplasms can lead to pulmonary nodules, notes Cleveland Clinic. Neoplasms can be benign or malignant. Benign neoplasms may be hamartomas, neurofibromas, blastomas or fibromas. Malignant neoplasms may be caused by lung cancer, or these neoplasms may be sarcomas, carcinoids, lymphomas or metastatic tumors.