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Frothy sputum is usually a symptom of some form of respiratory distress. Frothing occurs when phlegm or mucus in the lungs combines with fluid and air, and is then coughed up by a person. This is a symptom of several serious conditions, including pulmonary edema, pneumonia, tuberculosis, and even plague.
A less common cause of pink frothy sputum is plague, a severe infection caused by Yersinia pestis bacteria. It spreads via the bites of infected fleas found on rodents. Most people get the bubonic form of plague, which settles in the lymph nodes, and causes swellings called buboes.