In October, the sun shines for at least 7 hours per day but brace yourself for rain as there are on average 6 days of rainfall during the month. Around 70mm of rain falls throughout October with temperatures generally settling between 14 Â°C and 26 Â°C.
For example, ATP allosterically inhibits phosphofructokinase, but it activates the functionally opposite enzyme fructose-1,6-bisphosphatase (see slide 7.5.3). Similarly, phosphorylation inhibits glycogen synthase but activates glycogen phosphorylase, which degrades glycogen (slide 8.4.1).llosteric regulation of phosphofructokinase by AMP. To accomplish the stimulation of phosphofructokinase, AMP interacts with the enzyme at an allosteric binding site, that is, a site that is distant and functionally distinct from the active site.
This step is a direct nucleophilic attack of the hydroxyl group on the terminal phosphoryl group of the ATP molecule (Aleshin, 99). This produces glucose-6-phosphate and ADP. Hexokinase is the enzyme that catalyzes this phosphoryl-group-transfer.exokinase undergoes and induced-fit conformational change when it binds to glucose, which ultimately prevents the hydrolysis of ATP. It is also allosterically inhibited by physiological concentrations of its immediate product, glucose-6-phosphate.