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Causes of Pyogenic Granuloma. A pyogenic granuloma often occurs in areas of previous trauma including acne cysts. It is believed that this lesion is formed when capillary blood vessels start growing rapidly in response to trauma to the skin. These growths mostly occur after injuries, but the reason for this isnât known.
Expert: JE Sramek MD replied 7 years ago. The most common cause calcified granulomas of liver, lung, mediastinal lymph nodes and spleen is histoplasmosis. This is a fungus endemic to river valley regions (which is why I asked where you lived) and causes infections which are often mild and pass without evaluation.he presence of granulomas in the spleen is actually helpful because very, very few cancers which can be mistaken for granulomas metastasize to the spleen (Hodgkin's being the most common, and not typically calcified). Go see your grandbabies and worry about this later.