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How long does a BOTOXÂ® injection last? You can expect the effect of your BOTOXÂ® treatment to last anywhere from four to six months. As acetylcholine production returns to normal, your muscles will once again begin to contract and the wrinkles will reappear. That's the bad news. The good news is that your wrinkles may be less prominent after BOTOXÂ® treatment because your muscles may be somewhat trained to be in the more relaxed state. As the wrinkles reappear, you will have to have repeat BOTOXÂ® treatments to get them to disappear again.
The more regular you get your Botox injections, the longer you can enjoy the results and the longer the intervals are in between appointments. If you do this on a regular basis for 2 to 3 years, you will start having long-term results and less frequent injections.ou have to wait for about 3 days before you can actually see any difference. And it takes another 10 to 14 days before you can fully enjoy the results of Botox.