In these bearings, the roller is a cylinder, so the contact between the inner and outer race is not a point but a line. This spreads the load out over a larger area, allowing the bearing to handle much greater loads than a ball bearing. However, this type of bearing is not designed to handle much thrust loading.
The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated.This can either involve the replication of DNA in living organisms such as prokaryotes and eukaryotes, or that of DNA or RNA in viruses, such as double-stranded RNA viruses.n other eukaryotes, including humans, the DNA sequences at the replication origins vary. Despite this sequence variation, all the origins form a base for assembly of a group of proteins known collectively as the pre-replication complex (pre-RC):
Consideration of the influence of chromosome structure on DNA replication in bacteria and eukaryotes must also take into account the dif-ferent organization of DNA in the cell. The bacterial chromosome is as-sociated with the cell membrane but otherwise is exposed to the entire in-tracellular environment.In contrast, eukaryotic DNA replication occurs in a distinct compartment in the cell, affording the separation of proteins that may influence the initiation of DNA replication.ukaryotes have devised a DNA polymerase switching mechanism that involves the pol-a:primase complex in priming DNA replication at the origin of DNA replication and for every Okazaki fragment, and then a second DNA polymerase that is not associated with the primase (pol-6 or E) completing the synthesis (Figs.