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Causes. Nodules can be caused by a simple overgrowth of normal thyroid tissue, fluid-filled cysts, inflammation (thyroiditis), or a tumor (either benign or cancerous). Most nodules were surgically removed until the 1980s.
Most commonly, these cancerous nodules will be a specific type of thyroid cancer derived from the thyroid gland itself; hence they are referred to as primary thyroid tumors. Less frequently, a nodule may represent spread of cancer from elsewhere in the body (metastatic or secondary cancer).