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Causes of Pyogenic Granuloma. A pyogenic granuloma often occurs in areas of previous trauma including acne cysts. It is believed that this lesion is formed when capillary blood vessels start growing rapidly in response to trauma to the skin. These growths mostly occur after injuries, but the reason for this isnât known.
Diagnosis. If the diagnosis of pyogenic granuloma is possible, the doctor probably will need to do a skin biopsy. This is a procedure which involves: 1  Numbing the skin by injectable anesthetic. 2  Sampling of a small piece of skin by the use of a razor blade which is flexible, a scalpel or a tiny punch biopsy instrument.