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Causes of Pyogenic Granuloma. A pyogenic granuloma often occurs in areas of previous trauma including acne cysts. It is believed that this lesion is formed when capillary blood vessels start growing rapidly in response to trauma to the skin. These growths mostly occur after injuries, but the reason for this isnât known.
Granulomas can occur after injections. However, just because you have a lump it does not mean it is a granuloma. Lumps after injections can be caused by localized palpable product, hematomas, swelling and granulomas. The first three occur early since they are due to the product or the procedure.