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Causes. Nodules can be caused by a simple overgrowth of normal thyroid tissue, fluid-filled cysts, inflammation (thyroiditis), or a tumor (either benign or cancerous). Most nodules were surgically removed until the 1980s.
The most common type of hypothyroidism is that caused by primary thyroid gland failure. Basic causes of primary hypothyroidism are autoimmune, silent, postablative, goitrous, athyreotic and nonautoimmune (e.g., Riedel's), and subacute thyroiditis. Chronic autoimmune lymphocytic thyroiditis (Hashimoto's disease) is the most common cause of thyroid gland dysfunction. Replacement of lacking thyroid hormones reduces high blood pressure (BP) and total cardiovascular risk. Similar effects have also been described in subclinical hypothyroidism.