In October, the sun shines for at least 7 hours per day but brace yourself for rain as there are on average 6 days of rainfall during the month. Around 70mm of rain falls throughout October with temperatures generally settling between 14 Â°C and 26 Â°C.
For example, ATP allosterically inhibits phosphofructokinase, but it activates the functionally opposite enzyme fructose-1,6-bisphosphatase (see slide 7.5.3). Similarly, phosphorylation inhibits glycogen synthase but activates glycogen phosphorylase, which degrades glycogen (slide 8.4.1).llosteric regulation of phosphofructokinase by AMP. To accomplish the stimulation of phosphofructokinase, AMP interacts with the enzyme at an allosteric binding site, that is, a site that is distant and functionally distinct from the active site.
Phosphofructokinase (PFK) is an important enzyme in virtually all living cells. It performs the committed step in the glycolytic pathway, namely, the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. Glycolysis is a pathway that uses glucose to maintain a steady amount of ATP, the major energy carrier in living cells. Phosphofructokinase is a multisubunit protein. In such proteins, the subunits may behave cooperatively; that is, the activity of one subunit influences the activity of all the other subunits. Proteins that exhibit this behavior are known as allosteric proteins.