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Causes. Nodules can be caused by a simple overgrowth of normal thyroid tissue, fluid-filled cysts, inflammation (thyroiditis), or a tumor (either benign or cancerous). Most nodules were surgically removed until the 1980s.
Graves' disease. This is an auto-immune condition and is the commonest cause of an overactive thyroid gland. Toxic adenomas. Nodules develop in the thyroid gland and begin to secrete thyroid hormones, upsetting the body's chemical balance. Some goitres may contain several of these nodules. Subacute thyroiditis. This is where inflammation of the thyroid causes the gland to âleakâ excess hormones, resulting in temporary hyperthyroidism.