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Enteroendocrine cells of the intestine are the most numerous endocrine cells of the body. They constitute an enteric endocrine system as a subset of the endocrine system just as the enteric nervous system is a subset of the nervous system.
Describe the cell types located in the crypts of Lieberkhan. These intestinal glands are lined by goblet cells and intestinal absorptive cells. Enteroendocrine cells are found along their lateral borders. At the bottom of the gland are Paneth cells (zymogenic cells). The paneth cells contain large granules in their apical cytoplasm which contain zinc and lysozyme.