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MedPage Today Senior Writer. TORONTO, April 20 - A single oral dose of the antiemetic Zofran (ondansetron) can reduce vomiting by more than half and facilitate oral rehydration in children with gastroenteritis, according to pediatric emergency researchers.herefore it may be useful therapy in an emergency department for children with vomiting and mild-to-moderate dehydration as a result of gastroenteritis, they concluded. This study was supported by grants from the National Institutes of Health and GlaxoSmithKline, Zofran's maker.
While most cases of pediatric gastroenteritis are self-limiting, studies from the emergency setting show that a single dose of oral ondansetron can help reduce vomiting, the need for IV fluids, and hospital admission. non-randomized Canadian study suggested that standardized pathways for managing dehydration due to gastroenteritis in the ED might reduce IV use and length of stay with no effect on revisit rates. Adding ondansetron to such standardized gastroenteritis treatment pathways might benefit patients further.