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Causes. Nodules can be caused by a simple overgrowth of normal thyroid tissue, fluid-filled cysts, inflammation (thyroiditis), or a tumor (either benign or cancerous). Most nodules were surgically removed until the 1980s.
A thyroid nodule is simply a lump or mass in the thyroid gland. Thyroid nodules are relatively common; 6% of adult women and 2% of adult men in the U.S. have a thyroid nodule that can be felt on examination. Goiter can be the result of thyroid tumors, which are usually benign, but sometimes malignant. 2  Most thyroid tumors present as discrete nodules, but there are several kinds of thyroid cancer that can cause generalized swelling of the gland.