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Causes of Pyogenic Granuloma. A pyogenic granuloma often occurs in areas of previous trauma including acne cysts. It is believed that this lesion is formed when capillary blood vessels start growing rapidly in response to trauma to the skin. These growths mostly occur after injuries, but the reason for this isnât known.
Although granulomas due to histoplasmosis are noncancerous (benign), they may resemble cancer on an X-ray, especially if they haven't calcified. Granulomas eventually become calcified and have the same density as bone, making them more clearly visible on an X-ray.ranulomas are often found incidentally on a chest X-ray done for some other reason. The most common cause of lung granulomas in the United States is past histoplasmosis, a fungal infection that primarily affects the lungs.