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MedPage Today Senior Writer. TORONTO, April 20 - A single oral dose of the antiemetic Zofran (ondansetron) can reduce vomiting by more than half and facilitate oral rehydration in children with gastroenteritis, according to pediatric emergency researchers.herefore it may be useful therapy in an emergency department for children with vomiting and mild-to-moderate dehydration as a result of gastroenteritis, they concluded. This study was supported by grants from the National Institutes of Health and GlaxoSmithKline, Zofran's maker.
Though Zofran was originally created in 1984 to treat nausea and vomiting in cancer patients after receiving chemotherapy, the drug is most commonly used today by pregnant women. It metabolizes in the liver and has a shelf-life of five to seven hours. Common side effects of the drug are headaches and sometimes constipation.