Causes of sickle cell anaemia. Sickle cell anaemia is caused by a genetic mutation that affects the normal development of haemoglobin. A genetic mutation is a permanent change in the normal pattern of genetic information inside all living cells. This results in one or more of the body's processes not working properly.
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âState offices will be closed for the following holidays during 2016 1  : New Year's Day-Friday, January 1. 2  Martin Luther King, Jr.'s Birthday-Monday, January 18. 3  State Holiday-April 26 (To be observed on Monday, April 25). 4  Memorial Day-Monday, May 30. 5  Independence Day-Monday, July 4.