In post-marketing clinical studies, pitavastatin reduced LDL, Total Cholesterol (TC), non-HDL cholesterol and Apolipoprotein B (ApoB) by 26.2-48%, 16.6-37%, 22.5-45%, and 17.4-41%, respectively. Its effects on HDL and triglycerides varied and ranged from -6.9% to 17.8%, and -46% up to an increase of 21%, respectively.
Cats can have their first heat cycle between 4-6 months of age and will go in to heat approximately 3 times a year. Each litter typically has between 4 and 6 kittens. Dogs go into heat at about 4-6 months of age and typically have two heat cycles per year. Each litter has, on average, between 4 and 10 puppies. A dogâs heat cycle lasts a total of 30 days. The vagina will swell during the first 10 days. There will be bloody discharge during the next 10 days.
For the most part, itâs better to wait until a dog is at least two years old before allowing her breed. You want to make sure her body is fully developed and can handle the strain of giving birth to a litter of puppies. Female dogs normally go into heat twice per year, with each cycle lasting approximately 21 days. A mature female dog may go into heat every six months, although itâs common to skip some cycles. The period is characterized by a swollen vulva, a bloody discharge and mood changes. Itâs important to note here that these changes only mark the beginning of a dogâs heat period; they do not mean sheâs ready to mate.