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Causes of Pyogenic Granuloma. A pyogenic granuloma often occurs in areas of previous trauma including acne cysts. It is believed that this lesion is formed when capillary blood vessels start growing rapidly in response to trauma to the skin. These growths mostly occur after injuries, but the reason for this isnât known.
For autoimmune causes of granulomas there are multiple immune medications that must be used. A licensed doctor can differentiate between the different types and treatment. For a granuloma caused by a filler, massage works best initially. Steroid injection can then sometimes dissolve it.