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Common signs and symptoms of post-acute withdrawal can include:4. 1  Anxiety. 2  Depression. 3  Changes in mood.  Low 1  energy. Insomnia.  Poor 1  concentration. Low libido.  Unexplainable physical pain.
Such signs and symptoms are generally the opposite. of the intoxication effects of the particular substance. For example, pupils constrict during opioid. intoxication and dilate during acute withdrawal. These signs and symptoms begin within hours or days. after last use of the substance and gradually resolve. The length of time symptoms last depends on the. particular substance used. Exhibit 1 lists approximate. timeframes for acute withdrawal from several. substances.