In these bearings, the roller is a cylinder, so the contact between the inner and outer race is not a point but a line. This spreads the load out over a larger area, allowing the bearing to handle much greater loads than a ball bearing. However, this type of bearing is not designed to handle much thrust loading.
The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated.This can either involve the replication of DNA in living organisms such as prokaryotes and eukaryotes, or that of DNA or RNA in viruses, such as double-stranded RNA viruses.n other eukaryotes, including humans, the DNA sequences at the replication origins vary. Despite this sequence variation, all the origins form a base for assembly of a group of proteins known collectively as the pre-replication complex (pre-RC):
In theory, this abundance of potential replication origins in each replication unit or replicon might favor the activation of at least one origin per replicon (Karschau et al. 2012). This low usage of replication origins results from a flexible choice of replication origins in each cell . Thus, within a given cell population, each cell has the potential to activate a large number of origins (100,000 in mouse fibroblasts) and might use a different cohort of origins in an apparent stochastic manner.