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Causes. Nodules can be caused by a simple overgrowth of normal thyroid tissue, fluid-filled cysts, inflammation (thyroiditis), or a tumor (either benign or cancerous). Most nodules were surgically removed until the 1980s.
Other causes of hyperthyroidism include the following: 1  Thyroid nodules. 2  Taking too much thyroid hormone medication to treat other conditions. 3  Subacute thyroiditis. 4  This painful inflammation of the thyroid is usually caused by a virus.