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Enteroendocrine cells of the intestine are the most numerous endocrine cells of the body. They constitute an enteric endocrine system as a subset of the endocrine system just as the enteric nervous system is a subset of the nervous system.
1 Hormones produced in the islets of Langerhans are secreted directly into the blood flow by at least five different types of cells.  The hormones produced in the islets of Langerhans area of the pancreas are insulin, glucagon, and somatostatin.