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How long does a BOTOXÂ® injection last? You can expect the effect of your BOTOXÂ® treatment to last anywhere from four to six months. As acetylcholine production returns to normal, your muscles will once again begin to contract and the wrinkles will reappear. That's the bad news. The good news is that your wrinkles may be less prominent after BOTOXÂ® treatment because your muscles may be somewhat trained to be in the more relaxed state. As the wrinkles reappear, you will have to have repeat BOTOXÂ® treatments to get them to disappear again.
July 23, 2015 at 1:12 am #65738. I received my first round of Botox injections in mid-May. I am due for my next round next month. They have really helped me a lot but it feels like they are wearing off because I am starting to have more migraines and a return of the neck pain again. How far before your next round of Botox can you feel the Botox wearing off? Is it normal for it to wear off in about 2 months?