A debt-to-GDP ratio of 60% is quite often noted as a prudential limit for developed countries. This suggests that crossing this limit will threaten fiscal sustainability. For developing and emerging economies, 40% is the suggested debt-to-GDP ratio that should not be breached on a long-term basis.
1 Telomerase is found in high levels in germline cells (egg and sperm) and stem cells. 2  In these cells telomere length is maintained after DNA replication and the cells do not show signs of ageing. 3  Telomerase is also found in high levels in cancer cells.
The presence of telomerase in various human cancers and its absence in many normal cells mean the enzyme might serve as a good target for anticancer drugs. Agents able to hobble telomerase might kill tumor cells (by allowing telomeres to shrink and disappear) without disrupting the functioning of many normal cells.