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Causes. Nodules can be caused by a simple overgrowth of normal thyroid tissue, fluid-filled cysts, inflammation (thyroiditis), or a tumor (either benign or cancerous). Most nodules were surgically removed until the 1980s.
1. When the thyroid nodule is cancerous. Obviously if the nodule is malignant, then this would be a good reason to have it removed. Fortunately, most thyroid nodules are benign and cause no problems. In fact, only about 5% to 10% of nodules are malignant.