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MedPage Today Senior Writer. TORONTO, April 20 - A single oral dose of the antiemetic Zofran (ondansetron) can reduce vomiting by more than half and facilitate oral rehydration in children with gastroenteritis, according to pediatric emergency researchers.herefore it may be useful therapy in an emergency department for children with vomiting and mild-to-moderate dehydration as a result of gastroenteritis, they concluded. This study was supported by grants from the National Institutes of Health and GlaxoSmithKline, Zofran's maker.
Zofran has proven to be an effective medication to treat nausea and vomiting, but the medication never gained federal approval for use in pregnant women. Despite the lack of approval, women battling morning sickness took Zofran, Zuplenz (similar drug) or ondansetron (generic version) which some families claim led to birth defects. Zofran is approved to prevent nausea and vomiting caused by chemotherapy, radiation and surgery.