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A: Prednisone is a corticosteroid medication which is used to treat various inflammatory conditions including temporary use for relief of allergic reactions. Side effects associated with short term use of prednisone include insomnia, stomach upset, mood changes, increased appetite, and weight gain.: I have prednisone induced diabetes. A: Some of the side effects of prednisone may include: headache, mood changes, thin skin, acne, diabetes, loss of bone mass, glaucoma, and fluid retention. Prednisone may alter glucose regulation which can lead to high blood sugar.