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Enteroendocrine cells of the intestine are the most numerous endocrine cells of the body. They constitute an enteric endocrine system as a subset of the endocrine system just as the enteric nervous system is a subset of the nervous system.
There are many cell clusters in the pancreas referred to as islets of Langerhans that are responsible for the endocrine function of the organ. The islets are composed of groups or chains of endocrine cells, woven together to form a dense network. There are four types of cells in these islets, including: