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Common signs and symptoms of post-acute withdrawal can include:4. 1  Anxiety. 2  Depression. 3  Changes in mood.  Low 1  energy. Insomnia.  Poor 1  concentration. Low libido.  Unexplainable physical pain.
Heroin also produces profound degrees of tolerance and physical dependence. Tolerance occurs when more and more of the drug is required to achieve the same effects. With physical dependence, the body adapts to the presence of the drug and withdrawal symptoms occur if use is reduced abruptly. Withdrawal may occur within a few hours after the last time the drug is taken. Symptoms of withdrawal include restlessness, muscle and bone pain, insomnia, diarrhea, vomiting, cold flashes with goose bumps (âcold turkeyâ), and leg movements.