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MedPage Today Senior Writer. TORONTO, April 20 - A single oral dose of the antiemetic Zofran (ondansetron) can reduce vomiting by more than half and facilitate oral rehydration in children with gastroenteritis, according to pediatric emergency researchers.herefore it may be useful therapy in an emergency department for children with vomiting and mild-to-moderate dehydration as a result of gastroenteritis, they concluded. This study was supported by grants from the National Institutes of Health and GlaxoSmithKline, Zofran's maker.
Zofran is a brand name for the drug ondansetron, prescribed to treat or prevent nausea and vomiting. Doctors sometimes prescribe Zofran to treat nausea and vomiting caused by cancer treatments such as chemotherapy and radiation therapy.Zofran also can treat nausea and vomiting after surgery. For radiation therapy, a typical adult dose of Zofran is 24 mg daily. 2  For prevention of nausea and vomiting after surgery, a typical adult dose of Zofran is 16 mg before surgery.