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Causes of Pyogenic Granuloma. A pyogenic granuloma often occurs in areas of previous trauma including acne cysts. It is believed that this lesion is formed when capillary blood vessels start growing rapidly in response to trauma to the skin. These growths mostly occur after injuries, but the reason for this isnât known.
A granuloma is a small area of inflammation in tissue. Granulomas are most often the result of an infection and most frequently occur in the lungs, but can occur in other parts of the body as well. Granulomas are often found incidentally on a chest X-ray done for some other reason. The most common cause of lung granulomas in the United States is past histoplasmosis, a fungal infection that primarily affects the lungs. People who acquire pulmonary histoplasmosis that results in a lung granuloma have almost always spent some time in the Ohio River Valley or the upper Midwest.