Template:Aquatic layer topics. An abyssal plain is an underwater plain on the deep ocean floor, usually found at depths between 3000 and 6000 m. Lying generally between the foot of a continental rise and a mid-ocean ridge, abyssal plains cover more than 50% of the Earth âs surface.
Murad discovered in 1977 that nitroglycerin and related artery-widening compounds act by releasing nitric oxide. Furchgott later concluded that cells in the inner lining of blood vessels secrete some unknown substance that makes vessels dilate.
Nitric oxide pathway in pulmonary hypertension. Nitric oxide is a potent vasodilator (relaxes the blood vessels, opening them and making it easier for blood to flow through). Pulmonary hypertension patients have a decreased production of nitric oxide in their bodies. There are two classes of medications that target this pathway. Phosphodiesterase type 5 is a molecule in the body that interrupts the production of nitric oxide.