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Causes. Nodules can be caused by a simple overgrowth of normal thyroid tissue, fluid-filled cysts, inflammation (thyroiditis), or a tumor (either benign or cancerous). Most nodules were surgically removed until the 1980s.
Causes of Solitary Pulmonary Nodules. Solitary pulmonary nodules may have the following causes: Neoplastic (an abnormal growth that can be benign or malignant): Lung cancer; Metastasis (spread of cancer from other parts of the body to the lung) Lymphoma (a tumor made up of lymphoid tissue) Carcinoid (a small, slow-growing tumor that can spread)