The estates of the realm were the broad social orders of the hierarchically conceived society, recognised in the Middle Ages and Early Modern period in Christian Europe. There was no single system of dividing society into estates, and systems developed over time.The best known system is the French three-estate system that was used until the French Revolution: the clergy (first estate), the nobility (second estate), and commoners (third estate).Some countries considered burghers and rural commoners separate estates, notably Scandinavian nations and Russia.n addition, the First and Second Estates relied on the labour of the Third, which made the latter's unequal status all the more glaring. There were an estimated 27 million people in the Third Estate when the French Revolution started. Men and women shared the hard life of physical labour and food shortages.
Xeroderma pigmentosum: An inherited skin disorder characterized by photosensitivity with severe sunburn in infancy, the development of numerous pigmented spots resembling freckles, larger atrophic lesions associated with telangiectasis, and multiple solar keratoses.eroderma pigmentosum is listed as a  rare disease  by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Xeroderma pigmentosum, or a subtype of Xeroderma pigmentosum, affects less than 200,000 people in the US population.
1. Huntington's disease is an example of a genetic disorder caused by. a. a late-acting lethal dominant allele b. a nonlethal dominant allele. c. a late-acting recessive allele d. homozygous recessive alleles. e. multiple alleles.