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How long does a BOTOXÂ® injection last? You can expect the effect of your BOTOXÂ® treatment to last anywhere from four to six months. As acetylcholine production returns to normal, your muscles will once again begin to contract and the wrinkles will reappear. That's the bad news. The good news is that your wrinkles may be less prominent after BOTOXÂ® treatment because your muscles may be somewhat trained to be in the more relaxed state. As the wrinkles reappear, you will have to have repeat BOTOXÂ® treatments to get them to disappear again.
Part 2 of 6: How much Botox costs and how long the results last |. Botox is one of the most popular facial treatments for anti-aging and wrinkles, but it can be a little overwhelming if you don't know anything about it.art 2 of this section on Botox discusses how much Botox costs and how long Botox results last. Keep reading to find out if Botox will be worth your money! 1  Part 1: What Can Botox Do for You. 2  Part 2: How Much Botox Costs and How Long Results Last.