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Causes. Nodules can be caused by a simple overgrowth of normal thyroid tissue, fluid-filled cysts, inflammation (thyroiditis), or a tumor (either benign or cancerous). Most nodules were surgically removed until the 1980s.
Thyroid nodules are growths of cells in the thyroid gland. These growths can be: 1  Not cancer (benign) or thyroid cancer (malignant) 2  Fluid-filled (cysts) 3  One nodule or a group of small nodules.  Producing thyroid hormones (hot nodule) or not making thyroid hormones (cold nodule)