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MedPage Today Senior Writer. TORONTO, April 20 - A single oral dose of the antiemetic Zofran (ondansetron) can reduce vomiting by more than half and facilitate oral rehydration in children with gastroenteritis, according to pediatric emergency researchers.herefore it may be useful therapy in an emergency department for children with vomiting and mild-to-moderate dehydration as a result of gastroenteritis, they concluded. This study was supported by grants from the National Institutes of Health and GlaxoSmithKline, Zofran's maker.
Zofran works by blocking chemicals in the body responsible for nausea and vomiting. It can be taken orally, via a rapidly disintegrating tablet (ODT), or through injections. Pregnant women experiencing nausea and/or vomiting, however, are usually given the oral tablet, which typically starts around 8 mg per tablet, taken once or twice per day.