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Von Willebrand disease, type 2B: Introduction. Von Willebrand disease, type 2B: A rare inherited blood coagulation disorder characterized by a defect in plasma protein called the von Willebrand factor which leads to bleeding problems. Type 2 vWD is further subdivided into 4 subtypes, each with a different underlying genetic defect.
Von Willebrand's Disease (vWD). Von Willebrand's disease has been identified in a wide range of canine breeds, and is the most common of the inherited bleeding disorders.As with humans, there are three classifications of this disease, Types I, II, and III.ype III vWD is found in animals that have essentially no plasma vWF. The disease has been reported in many breeds of dog, and is generally diagnosed by an ELISA test for plasma vWF following a bleeding event. Five mutations have been identified that cause vWD in canines.