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Causes. Nodules can be caused by a simple overgrowth of normal thyroid tissue, fluid-filled cysts, inflammation (thyroiditis), or a tumor (either benign or cancerous). Most nodules were surgically removed until the 1980s.
1 Due to thyroid cancer. 2  Causing symptoms such as swallowing or breathing problems. 3  If the fine needle biopsy is inconclusive, and your provider can't tell whether the nodule is a cancer.  Making too much thyroid hormone.