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Causes of Pyogenic Granuloma. A pyogenic granuloma often occurs in areas of previous trauma including acne cysts. It is believed that this lesion is formed when capillary blood vessels start growing rapidly in response to trauma to the skin. These growths mostly occur after injuries, but the reason for this isnât known.
Benign Causes. One cause of a pedunculated lesion is what is called a pyogenic granuloma. With these, a small wound on the hand can be come irritated, causing the immune system to be activated. The resulting swelling and influx of immune cells will fill the area.