Onii can end with 3 different Japanese honourifics, -San, -Chan, or -Sama. -San is the basic ending for the basic big bro. -Sama is a bit of a formal ending for big brother, nothing too special. I really love my Onii-Chan!
Almost 300 million people suffer from acute malaria each year. 40 % of the worldâs population live in areas with malaria risk. Malaria, seen as a consequence of poverty, is also a major cause of poverty and its prevention is an important part of poverty alleviation.
1 Most cases of malaria and most of the deaths caused by malaria occur in Africa.  Although most cases of malaria are caused by Plasmodium falciparum or P. vivax, P. falciparum accounts for almost all of the deaths caused by malaria.