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Chronic pancreatitis is progressive inflammatory process in the pancreas that causes fibrosis (scarring of tissue), calcifications or stones, and dilated pancreatic duct. Adapted from Gorelick F, Pandol, SJ, Topazian M. Pancreatic physiology, pathophysiology, acute and chronic pancreatitis.
1 Chronic pancreatitis is inflammation that gets worse over time and leads to permanent damage in the pancreas. 2  Heavy alcohol use is the most common cause. 3  Other causes include heredity, cystic fibrosis, high levels of calcium or fats in the blood, certain medications, and some autoimmune conditions. Pancreatitis occurs when digestive enzymes become active inside the pancreas, attacking and damaging its tissues. 2  This can cause an enlarged pancreas. 3  Acute pancreatitis is inflammation that occurs suddenly in the pancreas. 4  It can be very serious, even life-threatening.