In October, the sun shines for at least 7 hours per day but brace yourself for rain as there are on average 6 days of rainfall during the month. Around 70mm of rain falls throughout October with temperatures generally settling between 14 Â°C and 26 Â°C.
For example, ATP allosterically inhibits phosphofructokinase, but it activates the functionally opposite enzyme fructose-1,6-bisphosphatase (see slide 7.5.3). Similarly, phosphorylation inhibits glycogen synthase but activates glycogen phosphorylase, which degrades glycogen (slide 8.4.1).llosteric regulation of phosphofructokinase by AMP. To accomplish the stimulation of phosphofructokinase, AMP interacts with the enzyme at an allosteric binding site, that is, a site that is distant and functionally distinct from the active site.
The concentration of Fructose-2,6-bisphosphate is lowered so glycolysis is inhibited. When PFK-2/F-2,6-bisphosphatase is phosphorylated (P*) by Protein kinase A in muscle, PFK-2 is activated and F-2,6-bisphosphatase is inhibited. The concentration of Fructose-2,6-bisphosphate is raised so glycolysis is activated.P and P* are two different sites on the PFK-2/F-2,6-bisphosphatase enzyme complex. The addition of P inhibits PFK-2 in liver but the addition of P* activates PFK-2 in muscle.I cannot explain the mechanism of activation of PFK-2 and glycolysis by insulin in muscle but it is the major control point. and P* are two different sites on the PFK-2/F-2,6-bisphosphatase enzyme complex. The addition of P inhibits PFK-2 in liver but the addition of P* activates PFK-2 in muscle.