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A circumstance is the condition in which something happens. Say you were at a business luncheon and you were accidentally fed psychedelic mushrooms in your ravioli, your boss might excuse the weird things you said, given the circumstance. Circumstance comes from the Latin meaning the conditions around something. If you are born in a war zone, you're born into a difficult circumstance. If you're making decisions about awarding a scholarship to the most needy person, you'll need information about each candidate's circumstances.
Negligence can be a tricky area of law to define. It describes a situation when someone accidently does something wrong, which causes someone else to get hurt. A person can be held liable for any damages they cause through their careless (or negligent) behavior.