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Chronic pancreatitis is progressive inflammatory process in the pancreas that causes fibrosis (scarring of tissue), calcifications or stones, and dilated pancreatic duct. Adapted from Gorelick F, Pandol, SJ, Topazian M. Pancreatic physiology, pathophysiology, acute and chronic pancreatitis.
Acute pancreatitis is usually caused by a gallstone getting stuck in the bile duct on its way from the gallbladder into the small intestine. Since the bile duct shares the same opening with the pancreatic duct, a sudden obstruction of the pancreatic opening will cause pancreatic juices to back up into the pancreas. This leads to the pancreatic duct system becoming swollen and inflamed, potentially causing pancreatic damage.