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The thymus is an organ composed of two lobes and is located directly in front of the heart and behind the sternum. It is a critical part of the immune system because it trains and modifies T cells that are used by the body to fight foreign materials that can cause sickness.
Once formed in the thymus, mature T cells migrate to peripheral lymphoid organs to initiate the cell-mediated immune response. Importantly, hormones can control thymus physiology, including T-cell development, and the thymus itself can also affect endocrine axes.