Carbapenems can only be given through an intravenous drip, which usually does not cause irritation at the injection site. If you have a severe allergy to penicillin, you generally should not be given a carbapenem. However, many patients with a mild or moderate allergy can tolerate carbapenems.
Alpha-1 adrenergic agonists. Alpha-1 adrenergic agonists stimulate alpha-1 receptors coupled to G proteins and phospholipase C. They can be classified in two groups: those which do not cross the blood-brain barrier and have peripheral effects and those which penetrate into the brain and have mainly central effects. Alpha-1 agonists with peripheral effects.
Curve A is for a full agonist, with an EC50 of about 3x10 (-8) M (intercept C). Curve B is for a partial agonist acting on the same receptor. Agonist. A drug which binds to a receptor and activates it, producing a pharmacological response (contraction, relaxation, secretion, enzyme activation, etc.).