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If you have a spinal or epidural procedure while you use Eliquis, tell your doctor at once if you notice any symptoms of nerve problems (eg, back pain, numbness [especially in the legs and feet], tingling, muscle weakness, paralysis, loss of bowel or bladder control).
Overdose of ELIQUIS increases the risk of bleeding [see Warnings and Precautions (5.2)] . In controlled clinical trials, orally administered apixaban in healthy subjects at doses up to 50 mg. daily for 3 to 7 days (25 mg twice-daily for 7 days or 50 mg once-daily for 3 days) had no. clinically relevant adverse effects.