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African trypanosomiasis or sleeping sickness is a parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei. There are two types that infect humans, Trypanosoma brucei gambiense (T.b.g) and Trypanosoma brucei rhodesiense (T.b.r.). T.b.g causes over 98% of reported cases. Both are usually transmitted by the bite of an infected tsetse fly and are most common in rural areas.
Sleeping sickness is most commonly spread through the bite of an infected tsetse fly. Even in areas where the disease occurs, only a small percentage of flies are generally infected. Tsetse flies are the size of a honey bee and are grey-brown. They usually bite during the daytime and their bites are usually quite painful. A human becomes infected with Trypanosoma brucei parasites when an infected tsetse fly feeds on his or her blood. The parasites that cause sleeping sickness, especially T. b. rhodesiense, can also infect cattle and wild animals. In rare cases, sleeping sickness can also be spread: