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When to Discard. Discard your ground beef if it's been out at room temperature for more than two hours, or after one hour on hot days. Other indicators that ground beef has gone bad include a gray or brown color throughout -- not just inside, which is normal -- and/or a sour smell.
Once it's been thawed out 3 days is the absolute limit it's safe to eat. After that feed it to the dog, or throw it out. I never use ground beef after the sell by date. Actually, I'm cautious about using it the date OF the sell by date.