Introduction. Indoleamine 2,3-dioxygenase (IDO-1) is a heme containing enzyme responsible for the initial step in the major pathway of l-tryptophan catabolism, the kynurenine (Kyn) pathway.ased on IDO-1 inhibitors such as PI, 1,4-naphthoquinone, 3-amino-2-naphthoic acid, benzothiazolethione and phenylmethanthiol, we first narrowed the list down to molecules containing potential heme ligators through the use of SMARTS-like strings in the MOE interface.
The most common symptoms of deviated septum include; 1  Difficulty breathing through one or both nostrils. 2  recurrent or chronic sinus infections. 3  Nasal drainage or post nasal dripping.  Noisy 1  breathing. crusting.  nasal bleeding.
It also helps to keep the inside of the nose moist. When the septum is deviated, one or both sides of the nose can become blocked. In these instances, surgery can help correct the deviation and improve airflow. The CT scan and picture of the nose shown below demonstrate show examples of a deviated nasal septum.