The drugs they looked at were heroin, cannabis, nicotine, alcohol, methadone, amphetamine and MDMA. As described in Scientific Reports, they found that, at the level of individual use, four substances were classified as high risk: alcohol, nicotine, cocaine and heroin.
Prepping the brisket. Start with a brisket in the 10- to 12-pound range, which is just the right size to fit on the grill. Trim off the excess top fat or âfat cap,â but leave a Â¼-thick layer of fat to keep the meat moist during the long cooking process. Sprinkle on a few tablespoons of rub, spreading it evenly on both sides of the brisket.
Cover the grill. 5. Smoke cook the brisket until tender enough to shred with your fingers; 6 hours will likely do it, but it may take as long as 8 (the cooking time will depend on the size of the brisket and heat of the grill). Baste the brisket from time to time with the fat and juices that accumulate in the pan.