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If you have a spinal or epidural procedure while you use Eliquis, tell your doctor at once if you notice any symptoms of nerve problems (eg, back pain, numbness [especially in the legs and feet], tingling, muscle weakness, paralysis, loss of bowel or bladder control).
ELIQUIS (APIXABAN) SIDE EFFECTS & INTERACTIONS: 1  The most serious complication is bleeding. Patients can bruise or bleed more easily when on this drug. 2  Let your doctor know if your gums bleed after brushing or flossing your teeth or if you experience nosebleeds or pink, red or brown urine.