Carbapenems can only be given through an intravenous drip, which usually does not cause irritation at the injection site. If you have a severe allergy to penicillin, you generally should not be given a carbapenem. However, many patients with a mild or moderate allergy can tolerate carbapenems.
Alpha-1 adrenergic agonists. Alpha-1 adrenergic agonists stimulate alpha-1 receptors coupled to G proteins and phospholipase C. They can be classified in two groups: those which do not cross the blood-brain barrier and have peripheral effects and those which penetrate into the brain and have mainly central effects. Alpha-1 agonists with peripheral effects.
Agonists. Agonists bind to and activate receptors in a dose-dependent manner until all opioid receptors are occupied. At this point, the response plateau is reached, and increased doses of agonist have no effect. However, continued use beyond this plateau may lead to respiratory depression and overdose.