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But different painkillers work better for different types of pain. For pain associated with inflammation, such as back pain or headaches, paracetamol and anti-inflammatory painkillers work best.If the pain is caused by sensitive or damaged nerves, as is the case with shingles or sciatica, it is usually treated with tablets that are also used for epilepsy and depression.ach of these tablets can also be used to treat pain caused by nerve sensitivity or nerve damage, such as shingles, diabetes nerve pain and sciatica. You donât have to have depression or epilepsy for these tablets to help your nerve pain. Amitriptyline and gabapentin both have to be prescribed by a GP.
Pain caused by nerve tissue damage often occurs as a burning, tingling, or stabbing sensation. Researchers say antidepressants have been used for neuropathic pain for many years, and this review of research shows that it is still probably the best approach to take. Antidepressants are thought to ease pain caused by nerve damage by dampening pain signals sent to the brain.