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How long is the drive from Charlotte, NC to Murrells Inlet, SC? The total driving time is 3 hours, 32 minutes.Your trip begins in Charlotte, North Carolina. It ends in Murrells Inlet, South Carolina. If you're planning a road trip, you might be interested in seeing the total driving distance from Charlotte, NC to Murrells Inlet, SC.ou can also calculate the cost to drive from Charlotte, NC to Murrells Inlet, SC based on current local gas prices and an estimate of your car's best gas mileage.
Answer   Depending on the route one takes and how long you drive each day, the answer can vary. As a rough estimate, the trip takes 3 to 5 days.   Be aware that the be â¦ low information does not include stops for fuel, food, rest, etc. Nor does it take into account road or weather conditions.he driving time would be approximately 3 hours if you were to drive non-stop in â¦ good driving conditions. (The driving time does not take into consideration conditions such as weather, road work and rush hour traffic in urban areas.). 11 people found this useful.