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1 If you are coming off a high dose of Subutex or Suboxone, cold turkey, the acute phase may not creep in until around the week mark. 2  Usually after 12 to 14 days you will see light at the end of the tunnel but some lingering withdrawals will last for up to six weeks, although these are more of a burden than a debility. Both Subutex and Suboxone have a 36 hour mean half-life which means half the drug will be out your system in 36 hours but this does not mean the other half will be gone 36 hours after this.
So after a week of taking the medication, the drug is now approximately considered only 4% effective, which is already recognized as cleared from the system. This rate also indicates how long Suboxone can block opiates in the body.After 74 hours, it is possible that the body will start getting high once again. Suboxone is colored orange andis usually lemone-lime in flavor. One part of this is naloxone for every four parts of buprenorphine.o after a week of taking the medication, the drug is now approximately considered only 4% effective, which is already recognized as cleared from the system. This rate also indicates how long Suboxone can block opiates in the body.