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Signs and symptoms of Leiomyosarcoma. People with early leiomyosarcoma often do not have any symptoms. Most leiomyosarcomas are diagnosed after a person develops symptoms. These may include: 1  a lump or swelling. 2  abdominal discomfort or bloatedness.3  swelling or pain in any area of the body.eiomyosarcoma. A leiomyosarcoma belongs to a group of rare cancers called soft tissue sarcomas. Sarcomas are cancers that develop in the supporting or connective tissues of the body, such as muscle, fat, nerves, blood vessels, bone and cartilage.
Symptoms. The most common signs and symptoms of dermatomyositis include: 1  Skin changes. 2  A violet-colored or dusky red rash develops, most commonly on your face and eyelids and on areas around your nails, knuckles, elbows, knees, chest and back. The rash, which can be patchy with bluish-purple discolorations, is often the first sign of dermatomyositis. 2  Muscle weakness. 3  Progressive muscle weakness involves the muscles closest to the trunk, such as those in your hips, thighs, shoulders, upper arms and neck.