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But different painkillers work better for different types of pain. For pain associated with inflammation, such as back pain or headaches, paracetamol and anti-inflammatory painkillers work best.If the pain is caused by sensitive or damaged nerves, as is the case with shingles or sciatica, it is usually treated with tablets that are also used for epilepsy and depression.ach of these tablets can also be used to treat pain caused by nerve sensitivity or nerve damage, such as shingles, diabetes nerve pain and sciatica. You donât have to have depression or epilepsy for these tablets to help your nerve pain. Amitriptyline and gabapentin both have to be prescribed by a GP.
There are several types of medication that help with nerve pain. However, not all of the ones listed here will necessarily work for your specific type of pain. The best choice for you depends on the cause of your pain, the severity, the potential side effects, and other factors.1  Anticonvulsants.2  The name might sound alarming, but some of these drugs can help people with nerve pain. 3  In fact, they're often considered a first choice.owever, not all of the ones listed here will necessarily work for your specific type of pain. The best choice for you depends on the cause of your pain, the severity, the potential side effects, and other factors. 1  Anticonvulsants. 2  The name might sound alarming, but some of these drugs can help people with nerve pain.