Introduction. Indoleamine 2,3-dioxygenase (IDO-1) is a heme containing enzyme responsible for the initial step in the major pathway of l-tryptophan catabolism, the kynurenine (Kyn) pathway.ased on IDO-1 inhibitors such as PI, 1,4-naphthoquinone, 3-amino-2-naphthoic acid, benzothiazolethione and phenylmethanthiol, we first narrowed the list down to molecules containing potential heme ligators through the use of SMARTS-like strings in the MOE interface.
The most common symptoms of deviated septum include; 1  Difficulty breathing through one or both nostrils. 2  recurrent or chronic sinus infections. 3  Nasal drainage or post nasal dripping.  Noisy 1  breathing. crusting.  nasal bleeding.
The only reasons to fix your deviated septum would be 1) you are finding it difficult to breathe through your nose 2) you have sleep apnea and fixing your septum may help with CPAP compliance 3) you are having severe, difficult to treat nosebleeds 4) you are looking for cosmetic rhinoplasty (of which a septoplasty may be a part).