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The suspension dosage formulation contains 20 mg phenylalanine per teaspoon. The average wholesale price (AWP) of a single 600 mg linezolid tablet is $56.31. Based on this pricing, a typical 10 day oral treatment regimen would cost over $1,000. The oral suspension price is $281.56 for 150 ml.
Linezolid may cause reversible optic neuropathy and irreversible peripheral neuropathy after months of treatment. Three cases of linezolid-induced optic and peripheral neuropathy are described, and previously reported cases of linezolid-induced optic neuropathy are reviewed. The mechanism of neural toxicity may be impairment of mitochondrial protein synthesis.