The drugs they looked at were heroin, cannabis, nicotine, alcohol, methadone, amphetamine and MDMA. As described in Scientific Reports, they found that, at the level of individual use, four substances were classified as high risk: alcohol, nicotine, cocaine and heroin.
Prepping the brisket. Start with a brisket in the 10- to 12-pound range, which is just the right size to fit on the grill. Trim off the excess top fat or âfat cap,â but leave a Â¼-thick layer of fat to keep the meat moist during the long cooking process. Sprinkle on a few tablespoons of rub, spreading it evenly on both sides of the brisket.
1 Barbecue brisket on a grill with charcoal requires you control the temperature with the bottom/side vents on your grill. Open the vent for more oxygen (heat). Adjust the top vent to at least half open, and leave it alone.  Put the smoker box/pouch over the coals.