Examples. 1  Contract research businesses such as Covance conduct many clinical trials and focus on improving efficiency at every step of the process. Eli Lilly Signs R&D Pact With Covance.
Excessive running or walking. Over-use of the thigh and hip muscles leading to the muscle weakness and excessive pressure in kneecap leading to the pain in knee. Wearing wrong shoes causes excessive stress on ligament, cartilage and knee cap resulting in early wear and tear.
Wearing heels shifts your weight to the balls of your feet, which puts pressure on your foot. This also creates a balance problem: It forces your knees and hips forward, hurting your back and legs. Wearing these shoes can cause: hyperextension, ankle sprains, midfoot fractures, neuromas (benign nerve tumors), pinched nerves, bunions and hammertoes.