Carbapenems can only be given through an intravenous drip, which usually does not cause irritation at the injection site. If you have a severe allergy to penicillin, you generally should not be given a carbapenem. However, many patients with a mild or moderate allergy can tolerate carbapenems.
Alpha-1 adrenergic agonists. Alpha-1 adrenergic agonists stimulate alpha-1 receptors coupled to G proteins and phospholipase C. They can be classified in two groups: those which do not cross the blood-brain barrier and have peripheral effects and those which penetrate into the brain and have mainly central effects. Alpha-1 agonists with peripheral effects.
1 Bind to the same receptors as full and partial agonists but do NOT cause activity at the receptor. 2  Antagonists block agonists and partial agonists from binding, preventing receptor activation altogether.