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Answer: Ischemic white matter disease refers to small blood vessels in the brain that are clogging up a bit. This is usually not a serious condition unless the amount of small vessel disease gets to a moderate or severe degree.It is often caused by high blood pressure, diabetes, high cholesterol, or smoking.nswer: Ischemic white matter disease refers to small blood vessels in the brain that are clogging up a bit. This is usually not a serious condition unless the amount of small vessel disease gets to a moderate or severe degree.
See below: It means you may have tiny lesions in white matter where nerve fibers extend away from nerve cells. The increased signals may indicate areas of injury due to ischemia (lack of oxygen) or other causes. They are too small and few in number to be significant.