Examples. 1  Contract research businesses such as Covance conduct many clinical trials and focus on improving efficiency at every step of the process. Eli Lilly Signs R&D Pact With Covance.
Excessive running or walking. Over-use of the thigh and hip muscles leading to the muscle weakness and excessive pressure in kneecap leading to the pain in knee. Wearing wrong shoes causes excessive stress on ligament, cartilage and knee cap resulting in early wear and tear.
Shoes that don't fit properly may be what causes leg cramps for some adults and children. In fact, when it comes to what causes leg cramps in women, high heel shoes are something to consider. Kidney dialysis can be a cause of leg cramps at night. Medications, including diuretics for high blood pressure, oral contraceptives, and statins.