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Answer: Ischemic white matter disease refers to small blood vessels in the brain that are clogging up a bit. This is usually not a serious condition unless the amount of small vessel disease gets to a moderate or severe degree.It is often caused by high blood pressure, diabetes, high cholesterol, or smoking.nswer: Ischemic white matter disease refers to small blood vessels in the brain that are clogging up a bit. This is usually not a serious condition unless the amount of small vessel disease gets to a moderate or severe degree.
Microscopically, the damaged white matter shows axonal swellings. These can occur anywhere but are particularly common in the parasagittal parts of the brain, the corpus callosum, fornix, internal capsule, and the brain stem. Axonal swellings can be detected with H&E and silver stains 15 hours after the injury.