1 Cover tightly. 2  Preheat oven to 425 degrees F for 15 minutes. 3  Place the roast in the oven and immediately reduce the temperature down to 200 degrees F. 4  Roast for about 4 hours or until the meat is falling-apart tender (cooking time will vary depending on the size of the roast).
intrinsic. adj. 1. of or relating to the essential nature of a thing; inherent. 2. (Anatomy) anatomy situated within or peculiar to a part: intrinsic muscles. [C15: from Late Latin intrinsecus from Latin, inwardly, from intrÄ within + secus alongside; related to sequÄ« to follow].
Glossary. Intrinsic factor is a glycoprotein secreted by parietal (humans) or chief (rodents) cells of the gastric mucosa. In humans, it has an important role in the absorption of vitamin B12 (cobalamin) in the intestine, and failure to produce or utilize intrinsic factor results in the condition pernicious anemia.Dietary vitamin B 12 is released from ingested proteins in the stomach through the action of pepsin and acid.n humans, it has an important role in the absorption of vitamin B12 (cobalamin) in the intestine, and failure to produce or utilize intrinsic factor results in the condition pernicious anemia. Dietary vitamin B 12 is released from ingested proteins in the stomach through the action of pepsin and acid.