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Porcine circovirus (PCV) is a single-stranded DNA virus (class II), that is nonenveloped with an unsegmented circular genome.The viral capsid is icosahedral and approximately 17 nm in diameter. PCV is a member of the virus family Circoviridae. PCVs are the smallest viruses replicating autonomously in eukaryotic cells.or example, concurrent infection with porcine parvovirus or PRRS virus, or immunostimulation lead to increased replication of PCV-2 and more severe disease in PCV-2-infected pigs.