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Answer: Ischemic white matter disease refers to small blood vessels in the brain that are clogging up a bit. This is usually not a serious condition unless the amount of small vessel disease gets to a moderate or severe degree.It is often caused by high blood pressure, diabetes, high cholesterol, or smoking.nswer: Ischemic white matter disease refers to small blood vessels in the brain that are clogging up a bit. This is usually not a serious condition unless the amount of small vessel disease gets to a moderate or severe degree.
On a CT of the brain, this would often be called age appropriate white matter changes or chronic small vessel ischemia. This is a result of cholesterol, hypertension, high blood sugar, and other factors that take their toll on the blood vessels of the body over time.