Introduction. Indoleamine 2,3-dioxygenase (IDO-1) is a heme containing enzyme responsible for the initial step in the major pathway of l-tryptophan catabolism, the kynurenine (Kyn) pathway.ased on IDO-1 inhibitors such as PI, 1,4-naphthoquinone, 3-amino-2-naphthoic acid, benzothiazolethione and phenylmethanthiol, we first narrowed the list down to molecules containing potential heme ligators through the use of SMARTS-like strings in the MOE interface.
The most common symptoms of deviated septum include; 1  Difficulty breathing through one or both nostrils. 2  recurrent or chronic sinus infections. 3  Nasal drainage or post nasal dripping.  Noisy 1  breathing. crusting.  nasal bleeding.
Deviated septum and sinus infections. A deviated septum will not usually cause problems with pain or vision; however a sinus infection can. The symptoms of a sinus infection are facial or sinus pain, headache, nasal drip, post nasal drip, stuffiness, and fever. It can also cause infections of the orbital or eye socket and the ears.