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Causes of Menorrhagia. There are many possible causes of heavy menstrual bleeding. They include: 1  Hormonal imbalance, particularly in estrogen and progesterone; this is most common in adolescents who recently began their periods and women who are getting close to menopause.
Menstrual Disorders, Fibroids & Polyps. Causes of Heavy Periods / Menstrual Flow. Menstrual flow is the result of the complex interplay of many factors that arise from the central nervous system, the pituitary gland, the ovary, the uterine muscle, and its lining. Regulation of menstrual flow is also dependent on a normally functioning clotting system.