In females (who have two X chromosomes), a mutation would have to occur in both copies of the gene to cause the disorder. Because it is unlikely that females will have two altered copies of this gene, it is very rare for females to have hemophilia.
There is currently no way to compensate for the absence of liver function in the long term, although liver dialysis techniques can be used in the short term. Artificial livers are yet to be developed to promote long term replacement in the absence of the liver.
Tests included in the CMP for liver dysfunction include: 1  Bilirubin: tests liver function and checks for signs of liver disease.  Liver Enzymes: Alanine aminotransferase (ALT), alkaline phosphatase (ALP) and aspartate aminotransferase (AST) are liver enzymes.