People who take opioids for pain relief for extended periods of time may need higher doses to ease their pain. They may develop tolerance to the drug and experience withdrawal symptoms if the medication is abruptly stopped. They become physically dependent on the drug.
Antibiotics most likely to cause C. diff infections are clindamycin, amoxicillin, ampicillin, and cephalosporins, and to a lesser extent, penicillin, erythromycin, and quinolones.
Risk factors for C. diff. infection include: Antibiotic use, especially a type of antibiotic that is broad-spectrum (is able to treat a wide variety of bacteria) or if you have been taking antibiotics for an extended period of time. Surgery of the gastrointestinal (GI) tract.