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You can run your package using DTEXEC, and change your connection by passing in a /CONNECTION parameter. Probably save it as a batch so next time you don't need to type the whole thing and just change the datasource as required. You can use the SSIS XML package configuration file. Here is a walk through.
For example, if you set a connection string that includes Database= AdventureWorks, and then reset the connection string to Data Source=myserver;Integrated Security=true, the Database property is no longer set to AdventureWorks. The connection string is parsed immediately after being set.