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1 doctor weighed in: How long does it take for ibuprophen to kick in? 1 doctor weighed in Want a second opinion? Most drugs taken orally will require digestion and absorption into the bloodstream. For ibuprofen, since it's not a particularly strong medication, it may take as long as 45 min to feel an effect. In brief: About 30-45 min.  Most drugs taken orally will require digestion and absorption into the bloodstream.
Depending on what painkiller, and why. If it's another NSAID, you should wait around 4 to 6 hours unless the dose of ibuprofen was low e.g. 200 mg. As for ibuprofen, if the pain didn't lessen after taking a dose of ibuprofen, if no stomach ache I would prefer one taking more ibuprofen up to maximum of 800 mg in total.