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Answer: Ischemic white matter disease refers to small blood vessels in the brain that are clogging up a bit. This is usually not a serious condition unless the amount of small vessel disease gets to a moderate or severe degree.It is often caused by high blood pressure, diabetes, high cholesterol, or smoking.nswer: Ischemic white matter disease refers to small blood vessels in the brain that are clogging up a bit. This is usually not a serious condition unless the amount of small vessel disease gets to a moderate or severe degree.
MainPlaceHolder. White matter in the brain is made of axons, which are like wires that carry messages between neurons and supporting cells. White matter sits underneath the brainâs cortex, or grey matter. In general, white matter damage (WMD) is caused by a lack of oxygen to that part of the brain. Periventricular leucomalacia (PVL) is a condition in which decreased blood flow to brain tissue causes it to soften up and eventually die.