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The thymus is an organ composed of two lobes and is located directly in front of the heart and behind the sternum. It is a critical part of the immune system because it trains and modifies T cells that are used by the body to fight foreign materials that can cause sickness.
Defining the role of the human thymus in reconstituting the peripheral T cell pool is important in the setting of bone marrow transplantation, cancer chemotherapy, and AIDS (1). T cell reconstitution by the thymus has the advantage of regenerating complete T cell repertoires capable of responding to new Ag challenges.