Introduction. Indoleamine 2,3-dioxygenase (IDO-1) is a heme containing enzyme responsible for the initial step in the major pathway of l-tryptophan catabolism, the kynurenine (Kyn) pathway.ased on IDO-1 inhibitors such as PI, 1,4-naphthoquinone, 3-amino-2-naphthoic acid, benzothiazolethione and phenylmethanthiol, we first narrowed the list down to molecules containing potential heme ligators through the use of SMARTS-like strings in the MOE interface.
Signs and symptoms. Only more severe cases of a deviated septum will cause symptoms of difficulty breathing and require treatment. Symptoms of a deviated septum include infections of the sinus and sleep apnea, snoring, repetitive sneezing, facial pain, nosebleeds, difficulty with breathing and mild to severe loss of the ability to smell. The nasal septum is the bone and cartilage in the nose that separates the nasal cavity into the two nostrils.
Repair of a Deviated Septum (Septoplasty) - Surgery Overview. The nasal septum is the wall between the nostrils that separates the two nasal passages. It supports the nose and directs airflow. The septum is made of thin bone in the back and cartilage in the front. A deviated septum occurs when the cartilage or bone is not straight. A crooked septum can make breathing difficult. The condition also can lead to snoring and sleep apnea.