People who take opioids for pain relief for extended periods of time may need higher doses to ease their pain. They may develop tolerance to the drug and experience withdrawal symptoms if the medication is abruptly stopped. They become physically dependent on the drug.
Antibiotics most likely to cause C. diff infections are clindamycin, amoxicillin, ampicillin, and cephalosporins, and to a lesser extent, penicillin, erythromycin, and quinolones.
The antibiotics most likely to cause diarrhea. Nearly all antibiotics can cause antibiotic-associated diarrhea, colitis or pseudomembranous colitis. The antibiotics most commonly linked to antibiotic-associated diarrhea include: 1  Cephalosporins, such as cefixime (Suprax) and cefpodoxime. 2  Clindamycin (Cleocin).