Introduction. Indoleamine 2,3-dioxygenase (IDO-1) is a heme containing enzyme responsible for the initial step in the major pathway of l-tryptophan catabolism, the kynurenine (Kyn) pathway.ased on IDO-1 inhibitors such as PI, 1,4-naphthoquinone, 3-amino-2-naphthoic acid, benzothiazolethione and phenylmethanthiol, we first narrowed the list down to molecules containing potential heme ligators through the use of SMARTS-like strings in the MOE interface.
The most common symptoms of deviated septum include; 1  Difficulty breathing through one or both nostrils. 2  recurrent or chronic sinus infections. 3  Nasal drainage or post nasal dripping.  Noisy 1  breathing. crusting.  nasal bleeding.
A. A deviated septum is a condition in which the nasal septum -- the bone and cartilage that divide the nasal cavity of the nose in half -- is significantly off center, or crooked, making breathing difficult.