Stickler syndrome or hereditary progressive arthro-ophthalmopathy[1] (ORPHA828) is a connective tissue disorder affecting about 1/7,500 to 1/9,000 newborns[2]. It is characterized by ocular, skeletal, orofacial, and auditory abnormalities.
Mayflower Park â Downtown Seattle Hotel. Mayflower Park â downtown Seattle Hotel â Welcome to the historic Mayflower Park Hotel. Ideally located in thriving downtown Seattle, the Mayflower Park is in the heart of the city. Built in 1927, the classic Mayflower Park Hotel has been lovingly restored with crystal chandeliers, gleaming brass and period antiques that offer an inviting European elegance to this historic Seattle hotel.
The Mayflower was hired in London, and sailed from London to Southampton in July 1620 to begin loading food and supplies for the voyage--much of which was purchased at Southampton. The Pilgrims were mostly still living in the city of Leiden, in the Netherlands.