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Anticoagulants are a type of anti-clotting medicine used to prevent harmful blood clots in the body. Blood clots can cause serious conditions like deep vein thrombosis (a blood clot in the veins of the legs), pulmonary embolism (a blood clot in the lungs), or a stroke (a blood clot in a blood vessel in the brain).
Mechanism of action of novel oral anticoagulants. Unlike traditional anticoagulant agents, the VKAs and heparins, novel OACs have been designed to inhibit specific single targets in the coagulation cascade (Figure 1) [9]. Rivaroxaban and apixaban directly inhibit Factor Xa, whereas dabigatran targets thrombin (Factor IIa).