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A: If your room temperature goes above about 80 degrees Fahrenheit, you would be safer to keep your insulin in the refrigerator. Q: I use an insulin pen. I have heard I should keep my pen at room temperature for only two weeks. But insulin in vials can be kept at room temperature up to 28 days.
After all, the only difference between opened insulin and unopened insulin is that little cap over the stopper. Yes the stopper is more porous but if the bottle is sitting in the fridge unused I suspect it has quite a long shelf-life in the refrigerator. We used to keep backup bottles for months at a time. But every time you draw from it, you not only inject air and potentially contaminants into the bottle but may slightly change the mix of ultralente and semilente insulin. So the more it's used, to me, the more likely you need to shortcut the life of the bottle.