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Anticoagulants are a type of anti-clotting medicine used to prevent harmful blood clots in the body. Blood clots can cause serious conditions like deep vein thrombosis (a blood clot in the veins of the legs), pulmonary embolism (a blood clot in the lungs), or a stroke (a blood clot in a blood vessel in the brain).
Nonsteroidal anti-inflammatory drugs, antibiotics and, in particular, rifampin are common precipitant drugs prescribed in primary care practice. Drugs with a narrow therapeutic range or low therapeutic index are more likely to be the objects for serious drug interactions. Object drugs in common use include warfarin, fluoroquinolones, antiepileptic drugs, oral contraceptives, cisapride and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.