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Updated October 22, 2016. The CRP (C-Reactive Protein) test is a blood test that measures the concentration of a special type of protein produced in the liver. The protein is present during episodes of acute inflammation or infection. In the body, CRP interacts with the complement system, an immunologic defense mechanism.
C-reactive protein (CRP) is an annular (ring-shaped), pentameric protein found in blood plasma, whose levels rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells.RP is synthesized by the liver in response to factors released by macrophages and fat cells (adipocytes). It is a member of the pentraxin family of proteins. It is not related to C-peptide (insulin) or protein C (blood coagulation). C-reactive protein was the first pattern recognition receptor (PRR) to be identified.