Onset of anisocoria: Old patient photographs often help to date anisocoria that is unaccompanied by other symptoms. Physical. Key aspects of the physical examination (eg, pupil size in light, pupil size in the dark, pupil reactivity to light and dark) help to localize the problem. Additional historical features such as pain, diplopia, ptosis, numbness, ataxia, dysarthria, or weakness help generate a differential diagnosis.
Mount Agung last erupted in 1963 (see information box in this article). This was one of the largest 20th century eruptions anywhere in the world. Historical eruptions of the volcano are poorly recorded, but there was certainly one in the 1820s.
More than 36,000 people were killed by the 1883 eruption of Krakatau, making it one of the deadliest volcanic disasters in historic time. Krakatau volcano lies in the Sunda strait between the islands of Java and Sumatra. In about 416 A.D., caldera collapse destroyed the volcano and formed a 4-mile (7-km) wide caldera. The islands of Krakatau, Verlaten, and Lang are remnants of this volcano. The eruption and collapse of the caldera in 1883 produced one of the largest explosions on Earth in recorded time (VEI=6) and destroyed much of Krakatau island, leaving only a remnant.