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But different painkillers work better for different types of pain. For pain associated with inflammation, such as back pain or headaches, paracetamol and anti-inflammatory painkillers work best.If the pain is caused by sensitive or damaged nerves, as is the case with shingles or sciatica, it is usually treated with tablets that are also used for epilepsy and depression.ach of these tablets can also be used to treat pain caused by nerve sensitivity or nerve damage, such as shingles, diabetes nerve pain and sciatica. You donât have to have depression or epilepsy for these tablets to help your nerve pain. Amitriptyline and gabapentin both have to be prescribed by a GP.
Prescription painkillers are powerful drugs that interfere with the nervous systemâs transmission of the nerve signals we perceive as pain. Most painkillers also stimulate portions of the brain associated with pleasure. The most powerful prescription painkillers are called opioids, which are opium-like compounds. They are manufactured to react on the nervous system in the same way as drugs derived from the opium poppy, like heroin.