The drugs they looked at were heroin, cannabis, nicotine, alcohol, methadone, amphetamine and MDMA. As described in Scientific Reports, they found that, at the level of individual use, four substances were classified as high risk: alcohol, nicotine, cocaine and heroin.
Prepping the brisket. Start with a brisket in the 10- to 12-pound range, which is just the right size to fit on the grill. Trim off the excess top fat or âfat cap,â but leave a Â¼-thick layer of fat to keep the meat moist during the long cooking process. Sprinkle on a few tablespoons of rub, spreading it evenly on both sides of the brisket.
The best temperature for brisket cooked on a grill is around 225Â°F (about 107Â°C) to 250Â°F (about 121Â°C), though cooking on a grill or in a smoker can be done as low as about 210Â°F (about 99Â°C). In an oven, the temperature can be set higher, to around 250Â°F (about 121Â°C) or 300Â°F (about 149Â°C).