In females (who have two X chromosomes), a mutation would have to occur in both copies of the gene to cause the disorder. Because it is unlikely that females will have two altered copies of this gene, it is very rare for females to have hemophilia.
There is currently no way to compensate for the absence of liver function in the long term, although liver dialysis techniques can be used in the short term. Artificial livers are yet to be developed to promote long term replacement in the absence of the liver.
See also: Liver Function Tests written for patients. Most tests measure hepatocellular damage rather than function, so they are rather misnamed. True liver function tests (LFTs) are those that measure synthesis of proteins made by the liver (albumin, clotting factors) or the liver's capacity to metabolise drugs. LFTs are not specific to specific systems or disease processes, yet abnormalities may indicate significant or serious disease.