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Alprazolam (Xanax) is a drug that relieves anxiety within about half an hour of oral intake. Most people who use Xanax say that a single dose kicks in 15- 30 minutes and its anti-anxiety effects last for a few hours.Taking it with food does not seem to affect its effects.Generally, a 0.25 mg dose is enough, but some variations among individuals may occur.ost people who use Xanax say that a single dose kicks in 15- 30 minutes and its anti-anxiety effects last for a few hours. Taking it with food does not seem to affect its effects. Generally, a 0.25 mg dose is enough, but some variations among individuals may occur.
However, Xanax remains in the bloodstream long after its anti-anxiety effects have worn off. Xanaxâs average half-life is 11 hours. This means that it takes an average of 11 hours for the body to eliminate half the Xanax dose. In older or obese people, or those with liver disease, Xanaxâs half-life is longer, as long as 40 hours.