Examples. 1  Contract research businesses such as Covance conduct many clinical trials and focus on improving efficiency at every step of the process. Eli Lilly Signs R&D Pact With Covance.
Excessive running or walking. Over-use of the thigh and hip muscles leading to the muscle weakness and excessive pressure in kneecap leading to the pain in knee. Wearing wrong shoes causes excessive stress on ligament, cartilage and knee cap resulting in early wear and tear.
High heels do cause a lot of pain in feet and also come under the major factors causing knee pain. An additional amount of strain is put on the shin muscles when you put on high heels shoes. This causes the pain in knee and leg. Apart from this, the extra height of heels can cause shortening of calf muscles.