(uncountable). 1  The application of a systematic, disciplined, quantifiable approach to the development, operation, and maintenance of software, and the study of these approaches. 2  That is the application of engineering to software.
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Post-translational modification (PTM) refers to the covalent and generally enzymatic modification of proteins during or after protein biosynthesis. Proteins are synthesized by ribosomes translating mRNA into polypeptide chains, which may then undergo PTM to form the mature protein product.