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If you have a spinal or epidural procedure while you use Eliquis, tell your doctor at once if you notice any symptoms of nerve problems (eg, back pain, numbness [especially in the legs and feet], tingling, muscle weakness, paralysis, loss of bowel or bladder control).
Eliquis Side Effects. Eliquis can cause numerous side effects, some deadly. Like all blood-thinners, Eliquis increases the risk of uncontrollable bleeding. The risk is increased when taken at the same time as popular drugs like Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).