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Updated October 22, 2016. The CRP (C-Reactive Protein) test is a blood test that measures the concentration of a special type of protein produced in the liver. The protein is present during episodes of acute inflammation or infection. In the body, CRP interacts with the complement system, an immunologic defense mechanism.
C-reactive protein is a substance that the body makes, and circulates in the blood in response to inflammation and infection. Itâs synthesized in the liver in response to factors released by fat cells. It serves as a good marker or indicator of heart disease risk. The test for high-sensitivity C-reactive protein is called hs-CRP test. A simple blood test can be done at the same time as a cholesterol screening.