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Answer: Ischemic white matter disease refers to small blood vessels in the brain that are clogging up a bit. This is usually not a serious condition unless the amount of small vessel disease gets to a moderate or severe degree.It is often caused by high blood pressure, diabetes, high cholesterol, or smoking.nswer: Ischemic white matter disease refers to small blood vessels in the brain that are clogging up a bit. This is usually not a serious condition unless the amount of small vessel disease gets to a moderate or severe degree.
Symptoms of White Matter Brain Disease. White matter brain disease results in the degeneration of white matter, which creates a large portion of the brain. The primary form of white matter brain disease is multiple sclerosis, which results in the destruction of the myelin sheath. In multiple sclerosis, there is defective formation or maintenance of the myelin because of dysfunction of the oligodendrocytes, a type of glial cell.