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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
The earliest bronze objects had tin or arsenic content of less than 2% and are therefore believed to be the result of unintentional alloying due to trace metal content in copper ores such as tennantite, which contains arsenic (Penhallurick 1986, p. 4).