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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
FYI â Hashimotoâs is the most common cause of hypothyroidism in the U.S. The 2011 study found that 25% of chronic idiopathic urticaria patients had positive antibodies for Hashimotoâs â 25%! That is significant.