Peripheral artery disease (P.A.D.) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.
Painless swelling may affect both legs and may include the calves or even the thighs. The effect of gravity makes the swelling most noticeable in the lower part of the body. Foot, leg, and ankle swelling is common when the person also: Is overweight.
Causes of Calf Swelling. A swollen calf may arise as a sign of inflammation following injury to one or more structures of the leg. Inflammation is a protective mechanism in the body to limit the damage to an area. It is also accompanied by pain with warmth and redness of the skin if it is superficial.