Peripheral artery disease (P.A.D.) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.
Painless swelling may affect both legs and may include the calves or even the thighs. The effect of gravity makes the swelling most noticeable in the lower part of the body. Foot, leg, and ankle swelling is common when the person also: Is overweight.
Deep venous thrombosis is a clot within the deep veins of the leg. The blood clot causes pain and swelling of the calf. This is a concerning condition, because if the clot breaks loose, it can travel to the lung and become lodged there, blocking blood flow into the lung.