Peripheral artery disease (P.A.D.) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.
Painless swelling may affect both legs and may include the calves or even the thighs. The effect of gravity makes the swelling most noticeable in the lower part of the body. Foot, leg, and ankle swelling is common when the person also: Is overweight.
Pain and tightness in the calf muscles may be caused by muscle fatigue, dehydration, heat or muscle cramps commonly known as a charley horse, according to WebMD. A person may also experience pain in the calf muscles when muscles and connective tissues along the shin bone are inflamed.