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Lithium has been used for over half a century for the treatment of bipolar disorder as the archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in this role. Despite this, the specific mechanisms by which lithium exerts its mood-stabilizing effects are not well understood.
The exact way in which the drug works to treat bipolar disorder is not known. Lithium may affect various chemicals in the brain called neurotransmitters, which could explain its effectiveness in treating bipolar disorder. Lithium is not a cure for the condition, however -- it only helps to control symptoms. (Click Lithium for more information on how lithium works, to find out what side effects may occur during treatment, and for suggestions on when and how to take this medication.) Advertisement. 5 Ways to Improve Your Mood.