Peripheral artery disease (P.A.D.) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.
Painless swelling may affect both legs and may include the calves or even the thighs. The effect of gravity makes the swelling most noticeable in the lower part of the body. Foot, leg, and ankle swelling is common when the person also: Is overweight.
Sciatica in the Calf Causes. Nerve issues in the calf related to a spinal causation are usually linked to L5 or S1 concerns, although L4 can be implicated in rare instances. Many patients are diagnosed with L5 or S1 nerve compression due to herniated discs or arthritic osteophytes.