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Macrovascular disease: Disease of the large blood vessels, including the coronary arteries, the aorta, and the sizable arteries in the brain and in the limbs. Macrovascular disease is by contrast to microvascular disease.
Macrovascular diabetes complications are diseases and conditions of the large blood vessels caused by diabetes. These complications can occur in blood vessels in any part of the body.Factors that can contribute to macrovascular complications are high blood sugar, insulin resistance, high cholesterol, high blood pressure, smoking, and abnormalities in blood clotting.Doctors do not understand what causes some people to develop diabetes complications while others do not.or example, if you smoke, you are at higher risk for heart and blood vessel disease than someone who does not smoke. Macrovascular diabetes complications include heart disease, stroke, and peripheral arterial disease.