Report Abuse. Yes, it is legally binding, providing that other statutes weren't broken in obtaining the IOU or in the agreement itself. If you threatened someone to get them to sign it, it's not legal. If it's for an illegal enterprise, it is not legal. If you are charging excessive interest, again, not legal.eport Abuse. Yes, it is legally binding, providing that other statutes weren't broken in obtaining the IOU or in the agreement itself. If you threatened someone to get them to sign it, it's not legal. If it's for an illegal enterprise, it is not legal. If you are charging excessive interest, again, not legal.
In the US (~320 million people), this amounts to about 320-500 patients at any one time. Acquired hemophilia can occur in association with other underlying conditions that involve the immune system, like cancer, other autoimmune diseases, pregnancy or even the use of certain medications (shown in pie chart below).
A defect in one of the genes that determines how the body makes blood clotting factor VIII or IX causes hemophilia. These genes are located on the X chromosomes (KRO-muh-somz). Chromosomes come in pairs. Females have two X chromosomes, while males have one X and one Y chromosome. Only the X chromosome carries the genes related to clotting factors. A male who has a hemophilia gene on his X chromosome will have hemophilia. When a female has a hemophilia gene on only one of her X chromosomes, she is a hemophilia carrierâ and can pass the gene to her children.