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Lithium has been used for over half a century for the treatment of bipolar disorder as the archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in this role. Despite this, the specific mechanisms by which lithium exerts its mood-stabilizing effects are not well understood.
Lithium is used to treat manic episodes in bipolar disorder. Common side effects of Lithium include weakness, nausea, loss of appetite, itching skin, thinning of the hair and tremors. Lithium toxicity increases with increasing serum lithium levels.