Papule: Papule is a solid, elevated lesion with no visible fluid which may be up to Â½. cm. in diameter. The elevation may be accounted for by metabolic deposits, infiltrates, or hyperplasia of cellular elements, etc. A papulosquamous lesion is a papule with desquamation (scaling).
What is the 'Pre-Market'. The pre-market is the period of trading activity that occurs before the regular market session. The pre-market trading session typically occurs between 8-9:30 a.m. EST each trading day.
Trading hours on the principal American stock markets, the New York Stock Exchange -- now called NYSE Euronext -- and the Nasdaq electronic system, are Monday through Friday from 9 a.m. until 4 p.m. Eastern time. Both markets also have premarket operations and extended hours until 8 p.m.