Known modulators of PKA activity include factors that either activate or inhibit AC (Adenylate Cyclase), resulting in an increase or decrease in cAMP (Cyclic Adenosine 3',5'-monophosphate) levels. The enzyme occurs naturally as a four-membered structure with two regulatory (R) and two catalytic (C) subunits.KA, once activated can phosphorylate several other substrates. The ADR-Alpha/Beta stimulation of cAMP-PKA phosphorylates several proteins related to excitation-contraction coupling like activation of RyR (Ryanodine Receptor), Pln (Phospholamban), CRP (C-Reactive Protein) but inhibits TnnI (Troponin-I).
If you feel like you canât get out of bed, donât. Serious fatigue, along with chills and body aches, are signs that you have the flu. So you need plenty of rest. Acetaminophen, naproxen, or ibuprofen can help with body aches.
How long is a person with the flu contagious? You can pass the flu to others from 1 day before you have symptoms up to 5-7 days after you get sick. Some people might be able to infect others even longer. Is there treatment? The flu can be treated with antiviral drugs if started soon after you get sick. They will help reduce how sick you get and how long you are ill. Over the counter drugs like acetaminophen or ibuprofen may be taken to increase comfort. People with the flu need rest and fluids.