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RH isoimmunization, also referred to as erythroblastosis fetalis is an incompatibility between an infantâs blood and the blood type of the mother.
If an Rh-negative pregnant woman is carrying an Rh-positive fetus, the fetus may be at risk of hemolytic disease of the newborn, in which antibodies made by the mother against the Rh antigen may cross the placenta and destroy the fetus's red blood cells. RhoGAM administered to pregnant Rh- women may prevent this disease.