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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Thatâs because zinc interferes with copper absorption, leading to copper deficiency, anemia, changes in red and white blood cells and lowered immunity (IOM 2001). In clinical studies, high zinc intake has been associated with a significant increase in hospitalization for genitourinary causes (ODS 2013b).