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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
While red causes the most problems, most other colors of standard tattoo ink are also derived from heavy metals (including lead, antimony, beryllium, chromium, cobalt nickel and arsenic) and can cause skin reactions in some people.