Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
In someone suffering with scleroderma, collagen (a protein manufactured by the connective tissues of the body) is produced in excess. This over-production of collagen can be likened to the process of scarring, which is the way the body heals a wound. For persons with scleroderma, the scarring gets out of hand.
Side Effects of Collagen. Most common side effect of collagen: Lingering taste in the mouth. A small percentage of users report that they get a slight lingering taste in their mouth. It usually subsides within 30-60 minutes. Side Effect 2: Possible allergic reaction for individuals allergic to collagen sources (bovine, porcine, fish, shellfish, chicken). Side Effect 3: Decreased appetite. Depending on your particular situation, this could be a side effect or a benefit. How common are the side effects of collagen supplements? These side effects are reported by approximately .1% of collagen supplement users. Other than in the case of allergies, the drawbacks, or side effects, of eating collagen appear to be negligible. Collagen Benefits. While the side effects are limited, the benefits of collagen supplements are vast, since collagen is a key component in the structure of the entire body. A list of common health and beauty benefits of collagen supplements are listed here: Primary Benefits