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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
1 Cadmium-is similar to mercury in toxicity. 2  Tissue levels of cadmium are often elevated in smokers. 3  Sources include cigarettes, art supplies and air pollution. 4  Aluminum-linked with Alzheimerâs disease, but very likely the real culprit is mercury that prevents the body from filtering aluminum.