Johann Sebastian Bach born, 21 March, at Eisenach. Youngest child of Johann Ambrosius Bach, town and court musician, and his wife Maria Elisabetha, nÃ©e LÃ¤mmerhirt. Baptised, 23 March.
â¢Parkinson disease 11 (PARK11): Type 11 Parkinson disease is linked to a genetic mutation on chromosome 2q21.2. Parkinson's disease is a chronic, progressive, degenerative brain disorder characterized by tremors, muscle rigidity and slowed movements.
378 2.4 The Synuclein family in Parkinson disease The SNCA gene is located on chromosome 4q21-22 and is associated with susceptibility to PD and DLB. Alpha-synclein has two paralogous genes, beta- (SNCB; MIM#602569) and gamma-synuclein (SNCG; MIM#602998) with which it shares a highly conserved N-terminal domain.fter the detection of SNCA locus triplication, SNCA duplications were also reported in two families from France and Italy (Chartier-Harlin et al., 2004, Ibanez et al., 2004). Chartier-Harlin et al detected one duplication family among nine ADPD.