Report Abuse. Yes, it is legally binding, providing that other statutes weren't broken in obtaining the IOU or in the agreement itself. If you threatened someone to get them to sign it, it's not legal. If it's for an illegal enterprise, it is not legal. If you are charging excessive interest, again, not legal.eport Abuse. Yes, it is legally binding, providing that other statutes weren't broken in obtaining the IOU or in the agreement itself. If you threatened someone to get them to sign it, it's not legal. If it's for an illegal enterprise, it is not legal. If you are charging excessive interest, again, not legal.
In the US (~320 million people), this amounts to about 320-500 patients at any one time. Acquired hemophilia can occur in association with other underlying conditions that involve the immune system, like cancer, other autoimmune diseases, pregnancy or even the use of certain medications (shown in pie chart below).
Patients with Hemophilia B have a defect in their Factor IX gene, such as deletions of variable length or point mutations. Patients with mild hemophilia maintain low levels of the clotting factor (5%-40% of the normal level in blood).To treat patents with mild hemophilia, gene therapy. Currently, patients with severe hemophilia can be administered recombinant, or artificial, clotting factor at defined intervals as a preventative measure.atients with Hemophilia B have a defect in their Factor IX gene, such as deletions of variable length or point mutations. Patients with mild hemophilia maintain low levels of the clotting factor (5%-40% of the normal level in blood). To treat patents with mild hemophilia, gene therapy.