Peripheral artery disease (P.A.D.) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.
Painless swelling may affect both legs and may include the calves or even the thighs. The effect of gravity makes the swelling most noticeable in the lower part of the body. Foot, leg, and ankle swelling is common when the person also: Is overweight.
Leg swelling can occur in any part of the legs, including the feet, ankles, calves and thighs. Leg swelling can result either from fluid buildup (fluid retention) or from inflammation in injured or diseased tissues or joints. Many of the causes of leg swelling, such as an injury or prolonged standing or sitting, are easily identified.