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Mar 13, '09. The headache comes because Morphine produces vasodilation. This is why we give Morphine for chest pain patients. The vasodilation is great to reduce constriction due to angina, but it causes headaches due to the vasodilation.
Naloxone, buprenorphine and other opioid antagonists prevent the agonists from binding with the body's opioid receptors. Exercise promotes the release of endorphins, which serve as the body's natural pain relievers. Morphine sulfate is a powerful narcotic that mimics the action of endorphins, the body's natural opiates.