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Lithium has been used for over half a century for the treatment of bipolar disorder as the archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in this role. Despite this, the specific mechanisms by which lithium exerts its mood-stabilizing effects are not well understood.
Lithium compounds, also known as lithium salts, are primarily used as a psychiatric medication. This includes in the treatment of major depressive disorder that does not improve following the use of other antidepressants and bipolar disorder. In these disorders, it reduces the risk of suicide.