Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
In someone suffering with scleroderma, collagen (a protein manufactured by the connective tissues of the body) is produced in excess. This over-production of collagen can be likened to the process of scarring, which is the way the body heals a wound. For persons with scleroderma, the scarring gets out of hand.
Collagen composes up to 80 percent of the skin. Its role is to maintain the skin's integrity, but collagen breaks down with advancing age. The breakdown of collagen during the aging process can lead to wrinkles, lines and folds. Collagen injections replenish the skin's natural collagen.Several types of Collagen fillers are on the market. For example, collagen fillers containing human collagen include CosmoDerm and Cosmoplast.he breakdown of collagen during the aging process can lead to wrinkles, lines and folds. Collagen injections replenish the skin's natural collagen. Several types of Collagen fillers are on the market. For example, collagen fillers containing human collagen include CosmoDerm and Cosmoplast.