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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Several mechanisms are utilized to remove the mercury. In order for these detoxification mechanisms to work properly, numerous essential minerals are utilized. Iodine, Zinc, Sulfur, Selenium, and Silica stimulate the excretion of heavy metals including mercury. Iodine is at the top of the list when it comes to mercury removal. Unfortunately, the average persons daily intake of Iodine is not high enough to keep them mercury free even when not exposed to excessive levels.