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Mar 13, '09. The headache comes because Morphine produces vasodilation. This is why we give Morphine for chest pain patients. The vasodilation is great to reduce constriction due to angina, but it causes headaches due to the vasodilation.
This makes it 5â10 times more potent than morphine and enhances its distribution into the brain making titration of the effects easier. In addition, due to the keto-group in position 6, hydromorphone is only glucuronidated at position 3, and does not form an active 6-glucuronide metabolite like morphine.