Peripheral artery disease (P.A.D.) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.
Painless swelling may affect both legs and may include the calves or even the thighs. The effect of gravity makes the swelling most noticeable in the lower part of the body. Foot, leg, and ankle swelling is common when the person also: Is overweight.
A calf strain can be caused by: 1  Stretching the calf muscles beyond the amount of tension that they can withstand. 2  Suddenly putting stress on the calf muscles when they are not ready for the stress. 3  Using the calf muscles too much on a certain day.  A direct blow to the calf muscles.