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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Welders are commonly exposed to the substances that cause metal fume fever from the base metal, plating, or filler. Brazing and soldering (a type of metal work in which only the filler is melted) can also cause metal poisoning from lead, zinc, copper, or cadmium in the filler metal.