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Cadmium is a naturally occurring toxic heavy metal with common exposure in industrial workplaces, plant soils, and from smoking. Due to its low permissible exposure to humans, overexposure may occur even in situations where trace quantities of cadmium are found. Cadmium is used extensively in electroplating, although the nature of the operation does not generally lead to overexposure. Cadmium is also found in some industrial paints and may represent a hazard when sprayed. Operations involving re
One of the most extreme forms of disease related to cadmium exposure by the oral route is itai-itai disease, described in Japan in the 1960s. Itai-itai disease is characterized by osteomalacia, osteoporosis, renal tubular dysfunction, malabsorption, and anemia. The bone effects are prominent features in humans suffering from itai-itai disease.