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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Other heavy metals such as mercury, aluminium and lead are toxic metals. They are neurotoxins (kill brain cells) and carcnogenic (cause cancer) and have no beneficial effect and their accumulation over time contributes to serious illness and heavy metal poisoning.