Peripheral artery disease (P.A.D.) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.
Painless swelling may affect both legs and may include the calves or even the thighs. The effect of gravity makes the swelling most noticeable in the lower part of the body. Foot, leg, and ankle swelling is common when the person also: Is overweight.
Calf pain in the absence of trauma or other symptoms is commonly due to a muscle cramp, also called a âcharley horse.â However, there are more serious conditions that lead to calf pain, such as peripheral artery disease.f you, or someone you are with, are experiencing calf or leg pain after mild exercise or exertion, or if you are experiencing pain, swelling, redness, and warmth in the calf, seek immediate medical care (call 911) . 9 Things to Know About Cortisone Injections. What Your Joint Pain Could Mean.