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Lithium has been used for over half a century for the treatment of bipolar disorder as the archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in this role. Despite this, the specific mechanisms by which lithium exerts its mood-stabilizing effects are not well understood.
Although these uses are not included in product labeling, lithium is used in certain patients with the following medical conditions: 1  Cluster headaches. 2  Mental depression. 3  Neutropenia (a blood condition where there is a decreased number of a certain type of white blood cells).