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A person should try clozapine for at least four to six weeks. Some symptoms, such as hallucinations, anxiety, paranoia, and bizarre behavior, should improve within that time; other symptoms may take longer. Additional improvements may be noticed over six to twelve months.here have been no confirmed cases of TD directly caused by clozapine alone, but patients should be regularly monitored for the development of TD. While agranulocytosis usually occurs most commonly within the first 4â6 months of treatment, you are at risk of this rare adverse effect for as long as you take clozapine.
Clozapine is usually used only in patients that have not responded to other anti-psychotic treatments due to its danger of causing agranulocytosis as well as the costs of having to have blood tests continually during treatment. It is, however, one of the most effective anti-psychotic treatment choices.hen carbamazepine is concurrently used with clozapine, it has been shown to decrease plasma levels of clozapine significantly thereby decreasing the beneficial effects of clozapine. Patients should be monitored for âdecreased therapeutic effects of clozapine if carbamazepineâ is started or increased.