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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
6. The toxic forms concept. A confusing fact is that nutrient minerals such as chromium, manganese, iron, copper, potassium and even calcium and others can be in a form that is highly toxic to the body. In other words, nutrient minerals can be in a form that makes them like toxic metals for the body.. The toxic forms concept. A confusing fact is that nutrient minerals such as chromium, manganese, iron, copper, potassium and even calcium and others can be in a form that is highly toxic to the body. In other words, nutrient minerals can be in a form that makes them like toxic metals for the body.