Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
In someone suffering with scleroderma, collagen (a protein manufactured by the connective tissues of the body) is produced in excess. This over-production of collagen can be likened to the process of scarring, which is the way the body heals a wound. For persons with scleroderma, the scarring gets out of hand.
Collagen Helps Heal Your Gut. It turns out that patients with inflammatory bowel disease have lowered serum levels of collagen in their bodies . Considering that collagen helps repair the tissues along the digestive tract, it makes sense that low collagen levels would cause irritation of a weak, collagen-deficient gut lining. Collagen Eases Joint Pain. When weâre young, a healthy amount of collagen sits between our joints, providing lubrication for easy movement.