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Mar 13, '09. The headache comes because Morphine produces vasodilation. This is why we give Morphine for chest pain patients. The vasodilation is great to reduce constriction due to angina, but it causes headaches due to the vasodilation.
Other common salt forms are morphine hydrochloride, morphine tartrate, and morphine citrate. In the body, the morphine is the active drug that binds to opiate receptors to reduce the perception of pain. From a chemistry perspective, morphine is an acidic drug.