Known modulators of PKA activity include factors that either activate or inhibit AC (Adenylate Cyclase), resulting in an increase or decrease in cAMP (Cyclic Adenosine 3',5'-monophosphate) levels. The enzyme occurs naturally as a four-membered structure with two regulatory (R) and two catalytic (C) subunits.KA, once activated can phosphorylate several other substrates. The ADR-Alpha/Beta stimulation of cAMP-PKA phosphorylates several proteins related to excitation-contraction coupling like activation of RyR (Ryanodine Receptor), Pln (Phospholamban), CRP (C-Reactive Protein) but inhibits TnnI (Troponin-I).
If you feel like you canât get out of bed, donât. Serious fatigue, along with chills and body aches, are signs that you have the flu. So you need plenty of rest. Acetaminophen, naproxen, or ibuprofen can help with body aches.
If you're very sick or you have other medical conditions, you might need treatment with prescription medications called antiviral drugs. These medicines -- oseltamivir (Tamiflu), peramivir (Rapivab), or zanamivir (Relenza) -- work best when you take them within 48 hours after your symptoms start. They can shorten the length of your illness by a day if you take them within this early window. They might help even after 2 days, if you have a bad case. Your doctor may want you to take antiviral drugs if you have a high risk of complications from the flu.