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Lithium has been used for over half a century for the treatment of bipolar disorder as the archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in this role. Despite this, the specific mechanisms by which lithium exerts its mood-stabilizing effects are not well understood.
Lithium and other mood stabilizers, certain antipsychotic drugs that treat bipolar depression, and sometimes antidepressants are used to treat bipolar depression. For mania, depression, or maintenance, these drugs might be used alone or in combinations.