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Lithium has been used for over half a century for the treatment of bipolar disorder as the archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in this role. Despite this, the specific mechanisms by which lithium exerts its mood-stabilizing effects are not well understood.
Lithium. The medication used most often to treat bipolar disorder is lithium. Lithium evens out mood swings in both directions â from mania to depression, and depression to mania â so it is used not just for manic attacks or flare-ups of the illness but also as an ongoing maintenance treatment for bipolar disorder.ithium evens out mood swings in both directions â from mania to depression, and depression to mania â so it is used not just for manic attacks or flare-ups of the illness but also as an ongoing maintenance treatment for bipolar disorder.