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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Metal fume fever, also known as brass founders' ague, brass shakes, zinc shakes, galvie flu, metal dust fever, Welding Shivers, or Monday morning fever, is an illness primarily caused by exposure to chemicals such as zinc oxide, aluminum oxide, or magnesium oxide which are produced as byproducts in the fumes that result when certain metals are heated. Other common sources are fuming silver, gold, platinum, chromium, nickel, arsenic, manganese, beryllium, cadmium, cobalt, lead, selenium, and zinc