Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
Scleroderma, a rare autoimmune disease characterized by abnormal connective tissue growth, can wreak havoc on everything from the skin and heart to lungs, teeth, speech, and movement. The overproduction of collagen causes the skin and organs to harden, leading them to atrophy and possibly fail.
Answer Wiki. One of the possible effects of creatine supplementation is the overdependence on external sources of creatine. When your body detects large amounts of creatine in your system, it might signal your organs to slow or stop production because your body is tricked into thinking it is overproducing creatine. Once you stop creatine supplementation, your body might not be able to begin synthesizing creatine immediately.