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RH isoimmunization, also referred to as erythroblastosis fetalis is an incompatibility between an infantâs blood and the blood type of the mother.
1 Rh sensitization is when a mother makes antibodies against her unborn fetusâ blood type, and causes destruction of that babyâs red blood cells.  The invention of Rhogam is one of the most important advances in modern obstetrics and has saved thousands of lives.