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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Thyroid Disease. If your thyroid glands are producing more hormones it can lead to itchy skin, and a condition known as hyperthyroidism. The condition is the result of Gravesâ disease in which a patients experiences thickening of the skin. The area will change to a red color and it will be itchy and hard.