Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
In someone suffering with scleroderma, collagen (a protein manufactured by the connective tissues of the body) is produced in excess. This over-production of collagen can be likened to the process of scarring, which is the way the body heals a wound. For persons with scleroderma, the scarring gets out of hand.
what the science says about the safety and side effects of colloidal silver colloidal silver can cause serious side effects the most common is argyria a bluish gray discoloration of the skin which is usually permanent colloidal silver can also cause poor absorption of some drugs such as certain antibiotics and thyroxine used to treat thyroid deficiency