Known modulators of PKA activity include factors that either activate or inhibit AC (Adenylate Cyclase), resulting in an increase or decrease in cAMP (Cyclic Adenosine 3',5'-monophosphate) levels. The enzyme occurs naturally as a four-membered structure with two regulatory (R) and two catalytic (C) subunits.KA, once activated can phosphorylate several other substrates. The ADR-Alpha/Beta stimulation of cAMP-PKA phosphorylates several proteins related to excitation-contraction coupling like activation of RyR (Ryanodine Receptor), Pln (Phospholamban), CRP (C-Reactive Protein) but inhibits TnnI (Troponin-I).
If you feel like you canât get out of bed, donât. Serious fatigue, along with chills and body aches, are signs that you have the flu. So you need plenty of rest. Acetaminophen, naproxen, or ibuprofen can help with body aches.
It's a good idea to call your doctor at the first signs of flu -- widespread body aches and a fever over 102 degrees F. Drugs called antivrals that you get from your doctor may shorten your illness, but you have to take them within 48 hours after symptoms start. Natural Cold & Flu Remedies.