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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Cerium is the most abundant of the lanthanides. It is more abundant than tin or lead and almost as abundant as zinc. It is found in a various minerals, the most common being bastnaesite and monazite. Cerium oxide is produced by heating bastnaesite ore, and treating with hydrochloric acid. Metallic cerium can be obtained by heating cerium(III) fluoride with calcium, or by the electrolysis of molten cerium oxide.