However, if a contractor submits a qualifying proposal before 50 percent of the not-to-exceed price has been obligated by the Government, then the limitation on obligations before definitization may be increased to no more than 75 percent (see 232.102-70 for coverage on provisional delivery payments).
Cartilage is an important structural component of the body. It is a firm tissue but is softer and much more flexible than bone. Cartilage is a connective tissue found in many areas of the body including: 1  Joints between bones e.g. the elbows, knees and ankles.2  Ends of the ribs.3  Between the vertebrae in the spine. 4  Ears and nose.artilage is a connective tissue found in many areas of the body including: 1  Joints between bones e.g. the elbows, knees and ankles. 2  Ends of the ribs. 3  Between the vertebrae in the spine. 4  Ears and nose.
Type II collagen. Type II collagen is the basis for articular cartilage and hyaline cartilage. It makes up 50% of all protein in cartilage and 85-90% of collagen of articular cartilage. Type II collagen does form fibrils. This fibrillar network of collagen allows cartilage to entrap the proteoglycan aggregate as well as provide tensile strength to the tissue. Oral administration of native collagen type II induces oral tolerance to pathological immune responses and may be useful in arthritis.