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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
2.ITAI-ITAI DISEASE. The strange disease that appeared in the downstream basin of the Jinzu River around 1912 was called by locals itai-itai byo (itai being what Japanese people say when infilicate with pain and byo literally meaning disease).