Peripheral artery disease (P.A.D.) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.
Painless swelling may affect both legs and may include the calves or even the thighs. The effect of gravity makes the swelling most noticeable in the lower part of the body. Foot, leg, and ankle swelling is common when the person also: Is overweight.
Calf and hamstring pain can be caused by sciatica, a condition in which your sciatic nerve is irritated. A pulled hamstring muscle near your knee joint or a pulled calf muscle near the knee induces pain. The bursas lubricating and cushioning your knee joint and the pelvic attachment of your hamstring muscle can become irritated and swollen, causing pain.