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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Itai-itai disease literally translates to âouch-ouchâ disease, named for the painful screams of its victims. Cadmium Poisoning Cadmium poisoning is a serious example of the toxicity of some metals in the body. In the body cadmium has no constructive function, meaning it serves no biological function except as a toxin. Cadmium is highly toxic even at low doses.