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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
In iodine-sufficient regions, the most common cause of hypothyroidism is Hashimoto's thyroiditis âalso an autoimmune disease. In addition, the thyroid gland may also develop several types of nodules and cancer.he thyroid may be affected by some frequent thyroid diseases. Hyperthyroidism occurs when the gland produces excessive amounts of thyroid hormones, the most common cause being Graves' disease âan autoimmune disorder.