Report Abuse. Yes, it is legally binding, providing that other statutes weren't broken in obtaining the IOU or in the agreement itself. If you threatened someone to get them to sign it, it's not legal. If it's for an illegal enterprise, it is not legal. If you are charging excessive interest, again, not legal.eport Abuse. Yes, it is legally binding, providing that other statutes weren't broken in obtaining the IOU or in the agreement itself. If you threatened someone to get them to sign it, it's not legal. If it's for an illegal enterprise, it is not legal. If you are charging excessive interest, again, not legal.
In the US (~320 million people), this amounts to about 320-500 patients at any one time. Acquired hemophilia can occur in association with other underlying conditions that involve the immune system, like cancer, other autoimmune diseases, pregnancy or even the use of certain medications (shown in pie chart below).
Hemophilia treatment will mainly depend on its severity and for patients with Hemophilia A or B involves clotting factor replacement therapy. There are two approaches: On demand - giving treatment to stop prolonged bleeding when it occurs. This is more common in the management of patients with mild hemophilia. Preventative treatment (prophylaxis) - medication to prevent bleeding episodes, and subsequent complications, such as joint and/or muscle damage. More commonly used for patients with moderate or severe hemophilia. Clotting factor concentrates