Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
In someone suffering with scleroderma, collagen (a protein manufactured by the connective tissues of the body) is produced in excess. This over-production of collagen can be likened to the process of scarring, which is the way the body heals a wound. For persons with scleroderma, the scarring gets out of hand.
Answer Wiki. One of the possible effects of creatine supplementation is the overdependence on external sources of creatine. When your body detects large amounts of creatine in your system, it might signal your organs to slow or stop production because your body is tricked into thinking it is overproducing creatine. Once you stop creatine supplementation, your body might not be able to begin synthesizing creatine immediately.