Peripheral artery disease (P.A.D.) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.
Painless swelling may affect both legs and may include the calves or even the thighs. The effect of gravity makes the swelling most noticeable in the lower part of the body. Foot, leg, and ankle swelling is common when the person also: Is overweight.
Bacterial skin infection known as cellulitis can cause calf swelling. Other symptoms include pain, warmth to the touch and redness. The leg is commonly affected. Any break in the skin can lead to infection, including minor scratches, bites, cuts or skin damage. Cellulitis can also occur with no apparent reason.