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RH isoimmunization, also referred to as erythroblastosis fetalis is an incompatibility between an infantâs blood and the blood type of the mother.
1 A fetus with severe Rh disease who survives the pregnancy may need a blood exchange. This procedure replaces most of the infant's blood with donor blood (usually type O, Rh-negative).  A history of pregnancy with Rh disease is a sign that you will need special treatment when you are pregnant with an Rh-positive fetus.