Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
In someone suffering with scleroderma, collagen (a protein manufactured by the connective tissues of the body) is produced in excess. This over-production of collagen can be likened to the process of scarring, which is the way the body heals a wound. For persons with scleroderma, the scarring gets out of hand.
1 Rheumatoid arthritis (RA). 2  Research on the effects of collagen type II in people with RA shows conflicting results. 3  Some research shows that taking collagen type II by mouth for 3 months reduces joint pain, swelling, and time to walk 15 meters in people with RA.hese side effects include nausea, heartburn, diarrhea and constipation, drowsiness, skin reactions, and headache. Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking collagen type II if you are pregnant or breast-feeding. Stay on the safe side and avoid use.