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Lithium has been used for over half a century for the treatment of bipolar disorder as the archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in this role. Despite this, the specific mechanisms by which lithium exerts its mood-stabilizing effects are not well understood.
Lithium is used as an integral component in the management of acute mania and unipolar and bipolar depressive disorder. It is also used as long-term prophylaxis of bipolar disorders. Thyroid abnormalities associated with lithium treatment have been widely reported in the medical literature over the last 5 decades. These include hypothyroidism, hyperthyroidism, unmasking or induction of autoimmune thyroiditis and goiter.