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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
A number of factors raise the risk of developing thyroid nodules. The most common ones include: 1  Mineral deficiencies. 2  Deficiencies of iodine and selenium are extremely common. 3  In fact it is rare to find an individual not deficient in these minerals.