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L-TRYPTOPHAN Overview Information. L-tryptophan is an amino acid, a protein building block that can be found in many plant and animal proteins. L-tryptophan is called an âessentialâ amino acid because the body canât make it. It must be acquired from food.
The conversion of niacin to tryptophan requires a coenzyme of vitamin B-6 called PLP, which is responsible for helping the enzyme kyneureninase to transport kyneurin into the niacin pathway. Without vitamin B-6, this PLP pathway can get diverted into another amino acid pathway, preventing the formation of niacin. Vitamin B-6 also works with iron and riboflavin during this conversion process. For your body to generate 1 milligram of niacin, you must consume 60 milligrams of tryptophan.