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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
The most common cause of hypothyroidism is Hashimoto's thyroiditis. Thyroiditis is an inflammation of the thyroid gland. Hashimoto's thyroiditis is an autoimmune disorder. With Hashimotoâs, your body produces antibodies that attack and destroy the thyroid gland. Thyroiditis may also be caused by a viral infection. Other causes of hypothyroidism include: Radiation therapy to the neck area. Treating certain cancers, such as lymphoma, requires radiation to the neck. Radiation damages the cells in the thyroid. This makes it more difficult for the gland to produce hormone. Radioactive iodine treatment.