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Hypochondriac comes ultimately from the Greek word hypokhondria, which literally means âunder the cartilage (of the breastbone).â In the late 16th century, when hypochondriac first entered the English language, it referred to the upper abdomen. The upper abdomen, it turns out, was thought to be the seat of melancholy at a time when the now-outdated medical theory of the four humors (blood, phlegm, yellow bile [choler], and black bile [melancholy]) was accepted as a basis for legitimate health practice.
the region of the body pertaining to the neck; also called the neck region. hypochondriac region. part of the abdominal region specific to the area just below the cartilage of the ribs, which includes a right and left hypochondriac region on either side of the epigastric region, also called the infrachondral region. Cranial.