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The cause of itai-itai disease was determined to be cadmium poisoning in the drinking water from the Jinzugawa River basin. The source of cadmium was discovered to be from Mitsui Mining and Smelting Company. Mitsui Mining began to discharge cadmium into the Jinzugawa River in 1910.
Several conditions can cause nodules to develop in your thyroid gland: 1  Iodine deficiency. 2  Lack of iodine in your diet can sometimes cause your thyroid gland to develop thyroid nodules. 3  But iodine deficiency is uncommon in the United States, where iodine is routinely added to table salt and other foods. Goiter is a term used to describe any enlargement of the thyroid gland, which can be caused by iodine deficiency or a thyroid disorder. 2  A multinodular goiter contains multiple distinct nodules within the goiter, but its cause is less clear. 3  Thyroid cancer.