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Addiction is defined as a chronic, relapsing brain disease that is characterized by compulsive drug seeking and use, despite harmful consequences. â  It is considered a brain disease because drugs change the brainâthey change its structure and how it works.
1 Brain changes that occur over time with drug use challenge an addicted personâs self-control and interfere with their ability to resist intense urges to take drugs. This is why drug addiction is also a relapsing disease.  Relapse is the return to drug use after an attempt to stop.