Peripheral artery disease (P.A.D.) is a disease in which plaque builds up in the arteries that carry blood to your head, organs, and limbs. Plaque is made up of fat, cholesterol, calcium, fibrous tissue, and other substances in the blood.
Painless swelling may affect both legs and may include the calves or even the thighs. The effect of gravity makes the swelling most noticeable in the lower part of the body. Foot, leg, and ankle swelling is common when the person also: Is overweight.
Tight calf muscles may be caused by a compartment syndrome. This is where the muscle becomes too big for the sheath surrounding the muscle causing pressure, sometimes pain and restricted movement. Biomechanical problems of the foot or from running style can increase the strain on the calf muscles.