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Lithium has been used for over half a century for the treatment of bipolar disorder as the archetypal mood stabilizer, and has a wealth of empirical evidence supporting its efficacy in this role. Despite this, the specific mechanisms by which lithium exerts its mood-stabilizing effects are not well understood.
In brief: Lithium. Lithium is a mood stabilizer for bipolar disorder with one of the highest efficacy rates upto 70 & and also decreases incidence of self harm.