Corticosteroids are also used supportively to prevent nausea, often in combination with 5-HT3 antagonists (e.g. ondansetron). Typical undesired effects of glucocorticoids present quite uniformly as drug-induced Cushing's syndrome.
Common causes. A gas explosion occurs when the gas/air mixture reaches a critical value, then any spark, flame or heat source can ignite the mixture. The explosion is caused when the rapidly expanding, burning gas is confined and builds up pressure. As the pressure builds, something has to give, and in a home gas explosion it is usually the windows.
Shortly after, a second more powerful one occurred, causing most of the damage and injuries with shock-waves felt many kilometres away. The second explosion generated seismic shock-waves with energy equivalent to 21 tonnes of TNT. The resulting fireballs reached hundreds of meters high. Around 11:40 (03:40 UTC) on 15 August, a series of eight explosions occurred in the port as fire from the original blasts continued to spread.