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RH isoimmunization, also referred to as erythroblastosis fetalis is an incompatibility between an infantâs blood and the blood type of the mother.
If you are Rh-negative, your red blood cells do not have a marker called Rh factor on them. Rh-positive blood does have this marker. If your blood mixes with Rh-positive blood, your immune system will react to the Rh factor by making antibodies to destroy it. This immune system response is called Rh sensitization.Rh sensitization can occur during pregnancy if you are Rh-negative and pregnant with a developing baby (fetus) who has Rh-positive blood.In most cases, your blood will not mix with your baby's blood until delivery.h sensitization during pregnancy can only happen if a woman has Rh-negative blood and only if her baby has Rh-positive blood. 1  If the mother is Rh-negative and the father is Rh-positive, there is a good chance the baby will have Rh-positive blood. 2  Rh sensitization can occur.