Inhibition of Adenylate Cyclase: The muscarinic receptor, through interaction with an inhibitory GTP-binding protein, acts to inhibit adenylyl cyclase. Reduced cAMP production leads to reduced activation of cAMP-dependent protein kinase, reduced heart rate, and contraction strength.
Scleroderma, a rare autoimmune disease characterized by abnormal connective tissue growth, can wreak havoc on everything from the skin and heart to lungs, teeth, speech, and movement. The overproduction of collagen causes the skin and organs to harden, leading them to atrophy and possibly fail.
1 Rumor: Mineral oil prevents the absorption of the collagen in your moisturizer. 2  FALSE The collagen in your moisturizer is too big to penetrate your skin (and thatâs a good thing!). 3  Therefore, mineral oil will have no effect on whether collagen gets absorbed or not.