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RH isoimmunization, also referred to as erythroblastosis fetalis is an incompatibility between an infantâs blood and the blood type of the mother.
The major antigens of the Rh system are encoded by RHD and RHCE genes on chromosome 1. Answering your questions. It is always important to know the genetic make-up of Rh system in a given geographical location. It is very important to avoid Rh immunization due to blood transfusion because of strong antigenicity of Rh system.