If you are very worried about it, go with the max of 72 hours between your last dose of methadone and first dose of sub, and try to have a plan in place to deal with some discomfort for those 2 days without either med...at the very least clear your schedule and be prepared to take it easy.
Twin Lakes is a census-designated place located in Lake County, Colorado, United States near the base of Mount Elbert. The population as of the 2010 Census was 171. Twin Lakes has the ZIP Code 81251. Lake County, one of the original 17 counties created by the Colorado legislature in 1861, was named for Twin Lakes.
The lake is located along the Apache Trail and about 16 miles east of Tortilla Flat, in Maricopa County, Arizona. It is about 65 miles (104 km) northeast of Phoenix. Apache Lake is formed by Horse Mesa Dam impounded the Salt River, which was completed in 1927. The second largest of the four Salt River Project reservoirs, Apache Lake is located about 5 miles (8 km) downstream from Theodore Roosevelt Lake (the largest), and upstream from Canyon Lake and Saguaro Lake.