The modern history of toothpaste began in 1892. That was the year Dr. Washington Sheffield of the USA invented the collapsible tube for storing toothpaste. Four years later in 1896, Colgate began making its own brand. The Early Toothpastes.
Prolog is relatively easy to deploy, and the cost for a small company to implement the system would be in the range of $10,000 for three concurrent licenses and another $10,000-15,000 for implementation and basic configuration.
This Probuphine price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies. The cost for Probuphine subcutaneous implant 74.2 mg is around $5,265 for a supply of 4 implant, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans. Probuphine is available as a brand name drug only, a generic version is not yet available.