M1, M3 and M5 receptors cause the activation of phospholipase C, generating two secondary messengers (IP3 and DAG) eventually leading to an intracellular increase of calcium, while M2 and M4 inhibit adenylate cyclase, thereby decreasing the production of the second messenger cAMP.
Keep your dog healthy and parvo-free with these 8 tips: Make sure your dog is properly vaccinated. Puppies should receive their first vaccines at 6-8 weeks of age; boosters should be administered at three-week intervals until the puppy is 16 weeks of age, and then again at one year of age. Previously vaccinated adult dogs need boosters every year.
Vaccination is the best defense against parvovirus. Your vet will recommend a course of vaccinations suitable for your dog. In puppies the first vaccine is typically given at about 6-8 weeks of age, and repeated every 4 weeks until 16-20 weeks of age, with yearly vaccines thereafter.isk Factors. Dogs of any age can get parvo, depending on their vaccination history, but some dogs are more susceptible than others: 1  Puppies 6-20 weeks old are most susceptible (it takes some time for the vaccination series to become fully protective).