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A high white blood cell count may be caused by a wide range of conditions, which include normal physiological responses to stress, allergic reactions, infection and serious conditions such as cancer. Treatment usually depends on the cause or disease.
If your white blood cell count is higher than normal, you may have an infection or inflammation. Or, it could indicate that you have an immune system disorder or a bone marrow disease.A high white blood cell count can also be a reaction to medication.1  Platelet count.ed blood cell count, hemoglobin and hematocrit. The results of your red blood cell count, hemoglobin and hematocrit are related because they each measure aspects of your red blood cells. If the measures in these three areas are lower than normal, you have anemia. Anemia causes fatigue and weakness.