According to Mayo Clinic, Down syndrome causes a distinct facial appearance, intellectual disability, developmental delays, and may be associated with thyroid or heart disease in a person. So calling people with this syndrome 'Mongoloid' is extremely vulgar and disrespectful to ethnic Mongolians. Likewise, how will the population react if Down Syndrome was associated with 'European' looks? If you use this term, you are automatically a xenophobic, in my opinion.
If any difference is noteworthy, it would probably be that an age is usually between two times, e.g. 1290-1450AD, whereas an era is less set - but that isn't a rule, its just a matter of usage. Synonyms would be epoch, or eon. Source(s):
Indeed, both eldest and oldest refer to the greatest in age. The crucial difference, however, lies in the fact that eldest can only be used for related persons, while oldest can be used for any person, place or thing in a group of related or unrelated elements. Examples: