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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
Inflammatory and immunologic causes of swollen lymph nodes include diseases such as rheumatoid arthritis and lupus, as well as sensitivity to some medications. Many cancers can also cause swelling of lymph nodes. These may be cancers that originate from the lymph nodes or blood cells, such as lymphomas and leukemias.