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The channel has a large diameter of 0.8x1.1nm, and is non-selective for small ions. However, it has an upper exclusion size limit corresponding to molecular weights of about 600 Dalton of permeants. Because most metabolites have molecular weights lower than 600 Da and have been shown to pass through porin channels, porins are called general diffusion pores.
Voltage-gated Na + channels are made up of two subunits: an Î±-subunit that is the pore domain of the channel through which Na + flows, and a Î²-subunit that has a number of functions, including regulating channel expression and interacting with the extracellular matrix and the cytoskeleton.