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Hand cramps are a result of hand muscles and nerve condition. A  common cause of cramping is dehydration, heat exhaustion, fatigue,  and injury or trauma of nerves. This is â¦also common in people with  diabetes and to any condition that affects the nerves outside the  brain and spinal cord. David BÃ¤ckman.
The second most common cause is dehydration. Cramps can also be caused by electrolyte and metabolic disorders. Diuretic drugs can commonly cause cramping through dehydration, sodium or potassium depletion. Parathyroid disease causes high or low calcium levels and is associated with cramping, as is thyroid dysfunction. Parathyroid and thyroid diseases are perhaps a more common cause of cramping in the hands and arms compared with other causes of cramping. The evaluation of cramping will commonly involve a drug history and blood studies checking sodium, potassium, magnesium and calcium levels as well as thyroid function tests.