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Pituitary dependent hypercortisolism, more commonly known as Cushing's disease, is caused by a pituitary tumor (non-cancerous) that triggers excessive levels of the stress hormone cortisol.
The most common cause of Cushings syndrome is a pituitary tumor (Cushings disease). Other causes of Cushings syndrome include adrenal tumors or cancers and tumors in other parts of the body, such as the lung, thymus or pancreas making the hormone ACTH (ectopic ACTH syndrome). It is important to determine that the patient has Cushings syndrome before the type of Cushings syndrome is investigated.