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Pituitary dependent hypercortisolism, more commonly known as Cushing's disease, is caused by a pituitary tumor (non-cancerous) that triggers excessive levels of the stress hormone cortisol.
A benign pituitary tumor secretes ACTH. This tumor, called a pituitary adenoma, is by far the most common tumor linked to Cushingâs syndrome. As a result, the condition it causes has been given its own name, Cushingâs disease. Pituitary adenomas account for 70% (in adults) to more than 90% (in children) of endogenous (non-medicine-related) Cushingâs syndrome cases.