1 Preheat the oven to 300 degrees F (150 degrees C).  Warm the au jus sauce in a saucepan over medium heat. Add the roast beef and let it warm up at the same time. While the meat is soaking, place the rolls on a baking sheet with the cut side down. Brush the tops lightly with water and sprinkle with salt and caraway seeds.
PK/PD models. PK/PD modeling (pharmacokinetic/pharmacodynamic modeling) (alternatively abbreviated as PKPD or PK-PD modeling) is a technique that combines the two classical pharmacologic disciplines of pharmacokinetics and pharmacodynamics.
Projections Research, Inc. uses population pharmacokinetic (PK) and pharmacodynamic (PD) models to describe the time course of individual patient exposure and response to a new treatment. PK is the study of how the body processes a drug and PD is the study of how the drug acts on the body. Population PK/PD models are used to determine how patient factors such as demographics, disease status and progression, and co-medications, might affect patient exposure to drug and their subsequent response.