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Numerous experimental observations suggest that local factors play a major role in the pathophysiology of restenosis. Angioplasty is invariably associated with arterial injury that provides a potent stimulus for both platelet adhesion and platelet aggregation.umerous experimental observations suggest that local factors play a major role in the pathophysiology of restenosis. Angioplasty is invariably associated with arterial injury that provides a potent stimulus for both platelet adhesion and platelet aggregation.
Restenosis involves a series of events that result in significant renarrowing of the lumen of the treated vessel. After PCI, the body attempts to repair the damage caused by the procedure-related mechanical injury.