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pepsinogen. a zymogen secreted by the chief cells of the gastric glands and converted into pepsin in the presence of gastric acid or of pepsin itself.plasma pepsinogen. high levels are indicative of extensive mucosal damage in the abomasum, as in ostertagiasis in ruminants. proenzyme formed and secreted by the chief cells of the gastric mucosa; the acidity of the gastric juice and pepsin itself remove 42 amino acid residues from pepsinogen to form active pepsin. Synonym(s): propepsin. [ pepsin + G. -gen, producing].
Activation of pepsinogen in the stomach. The peptidase in the stomach is pepsin. Pepsin works optimally in the acidic environment of the stomach, being active at pH 2-3, but becoming inactivated when the pH is above 5. The chief cells at the base of the gastric glands secrete the zymogen, which is called pepsinogen.Activation of pepsinogen starts when hydrocholoric acid (HCl) , which is secreted by the parietal cells partially activates pepsinogen (pepsinogen* in figure).This partially active enzyme then cleaves the peptide from other pepsinogen molecules to form active pepsin.he chief cells at the base of the gastric glands secrete the zymogen, which is called pepsinogen. Activation of pepsinogen starts when hydrocholoric acid (HCl) , which is secreted by the parietal cells partially activates pepsinogen (pepsinogen* in figure).