a river in E Asia, forming most of the boundary between N Manchuria and the SE Russian Federation, flowing into the Sea of Okhotsk. About 2700 miles (4350 km) long.
High blood pressure is dangerous, partly because there are no symptoms, so organ damage can occur slowly without being recognized. Renal hypertension can cause chronic kidney disease. This is a slow decline in kidney function. Until the condition is well advanced, chronic kidney disease also causes no symptoms. Because there are usually no symptoms, a doctor may suspect renal hypertension when someone has uncontrolled high blood pressure despite multiple medications or has unexplained chronic kidney disease.
The damage to glomerular artery and nephrons due to hypertension is focal, but kidney function decline in the late term is progressive. On one hand, high blood pressure can impair kidneys, and kidney damage aggravates hypertension; they two form a vicious circle, and cause pathological changes in normal small artery and nephrons. On the other hand, hypertension induced nephrons injury can cause compensatory high perfusion and high filtration in remaining normal nephrons.