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Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.n similar manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over another, and, although most of these agents do act as D 2 agonists, they affect other subtypes as well.
So how does dopamine act on the indirect pathway? Dopamine is secreted by the substantia nigra and binds to D2 receptors (these are different than the D1 receptors of the direct pathway) in the striatum.This causes striatal neurons to decrease their inhibitory message to the external segment of the globus pallidus.his is different from the direct pathway where the striatum sends a signal to the internal segment of the globus pallidus. The external segment of the globus pallidus normally indirectly (more on this in the next few paragraphs) inhibits its internal counterpart.