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A cortisol test measures the level of the hormone cortisol in a 24-hour sample of urine. The cortisol level may show problems with the adrenal glands or the pituitary gland. Cortisol is made by the adrenal glands.
Cortisol & Adrenal Function. Cortisol is a life sustaining adrenal hormone essential to the maintenance of homeostasis. Called âthe stress hormone,â cortisol influences, regulates or modulates many of the changes that occur in the body in response to stress including, but not limited to: 1  Blood sugar (glucose) levels.2  Fat, protein and carbohydrate metabolism to maintain blood glucose (gluconeogenesis).3  Immune responses.alled âthe stress hormone,â cortisol influences, regulates or modulates many of the changes that occur in the body in response to stress including, but not limited to: 1  Blood sugar (glucose) levels. 2  Fat, protein and carbohydrate metabolism to maintain blood glucose (gluconeogenesis). 3  Immune responses.