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Hand cramps are a result of hand muscles and nerve condition. A  common cause of cramping is dehydration, heat exhaustion, fatigue,  and injury or trauma of nerves. This is â¦also common in people with  diabetes and to any condition that affects the nerves outside the  brain and spinal cord. David BÃ¤ckman.
Cramps or spasms in the muscles often have no clear cause. Possible causes of hand or foot spasms include: 1  Brain disorders, such as parkinson's disease, multiple sclerosis, dystonia, and Huntington's disease.2  Chronic kidney disease and dialysis.3  Damage to a single nerve or nerve group (mononeuropathy) or multiple nerves (polyneuropathy) that are connected to muscles.ossible causes of hand or foot spasms include: 1  Brain disorders, such as parkinson's disease, multiple sclerosis, dystonia, and Huntington's disease.