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The initial symptoms of liver failure are often ones that can be due to any number or conditions. Because of this, liver failure may be initially difficult to diagnose. Early symptoms include: 1  Nausea. 2  Loss of appetite. 3  Fatigue.he initial symptoms of liver failure are often ones that can be due to any number or conditions. Because of this, liver failure may be initially difficult to diagnose. Early symptoms include: 1  Nausea. 2  Loss of appetite. 3  Fatigue.
Quick Answer. Signs and symptoms of liver disease in both men and women may include swelling in the ankles and legs, abdominal swelling or pain, chronic fatigue and a loss of appetite, states Mayo Clinic. Additional symptoms may include yellowish skin and eyes, itchy skin, nausea or vomiting, and dark urine color.