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Search form. Causes. The cause or causes of lymphoma are largely a mystery. There may be some genetic predisposition, or it may be caused by an environmental trigger such as pollution. There is not, however, sufficient evidence to provide a definitive answer.
Cancer. 1  Lymphoma is cancer of the lymph node and there are two forms of lymphomas â Hodgkinâs disease and non-Hodgkinâs disease. 2  Leukemia is cancer of the blood forming tissues, including bone marrow and lymphatic system and may cause lymph node enlargement. 3  Melanoma â a type of skin cancer.