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What to do about a droopy brow or eyelid. The effect of the Botox will last about three to four months. That is a long time to go around looking droopy on one side, but there are some options available to improve the situation.
 T.M. A: Botox weakens the muscles that cause wrinkles in the skin that overlies those muscles. Dermal fillers are injected directly into the wrinkle to plump up the skin and smooth the surface. Botox can last up to three months and fillers can last up to a year.T.M. A: Botox weakens the muscles that cause wrinkles in the skin that overlies those muscles. Dermal fillers are injected directly into the wrinkle to plump up the skin and smooth the surface. Botox can last up to three months and fillers can last up to a year.