A regulatory framework Although common in other process manufacturing industries (e.g., food and chemicals), continuous processing is at a nascent stage in the pharmaceutical industry, where batch manufacturing is the prevailing mode.
When the motor neurons in the brainstem are affected (bulbar ALS), the muscles used in speech and swallowing are impaired. ALS only affects muscles that are moved voluntarily (such as those in the mouth or arm) and does not impact those muscles involved in involuntary movements, such as digestion.
Symptoms. Early signs and symptoms of ALS include: 1  Difficulty walking, tripping or difficulty doing your normal daily activities. 2  Weakness in your leg, feet or ankles. 3  Hand weakness or clumsiness. 4  Slurring of speech or trouble swallowing. 5  Muscle cramps and twitching in your arms, shoulders and tongue.arly signs and symptoms of ALS include: 1  Difficulty walking, tripping or difficulty doing your normal daily activities. 2  Weakness in your leg, feet or ankles. 3  Hand weakness or clumsiness.