Chronic active hepatitis is a long-term on-going inflammation of the liver, i.e. when the condition has lasted for more than six weeks. This is what canine hepatitis really means, a chronic liver inflammation. Many diseases can result in chronic active hepatitis in dogs. The cause can also be virus or a toxin causing liver damage. Some dog breeds also seem more susceptible to get chronic inflammatory hepatic disease.
Acid hydrolysis of esters is reversible: Alkaline hydrolysis of esters is irreversible, since it gives an alcohol and a salt of the acid: This process is used extensively in industry to make alcohols and acidsâfor example, in the saponification of fats to make glycerol and salts of higher acyclic acids (soaps).lkaline hydrolysis of esters is irreversible, since it gives an alcohol and a salt of the acid: This process is used extensively in industry to make alcohols and acidsâfor example, in the saponification of fats to make glycerol and salts of higher acyclic acids (soaps).
In other words the reaction can be reversible. The enzyme can continue locking with a substrate and continue it's catalysts activity. If the pH is too high or too low it can change the shape of the enzyme. The ionic bonds that hold the shape of the enzyme are broken changing the 3D shape of the enzyme.