A regulatory framework Although common in other process manufacturing industries (e.g., food and chemicals), continuous processing is at a nascent stage in the pharmaceutical industry, where batch manufacturing is the prevailing mode.
When the motor neurons in the brainstem are affected (bulbar ALS), the muscles used in speech and swallowing are impaired. ALS only affects muscles that are moved voluntarily (such as those in the mouth or arm) and does not impact those muscles involved in involuntary movements, such as digestion.
In the early stages, the symptoms of ALS -- also called Lou Gehrig's disease -- include: 1  Increasing weakness in one limb, especially in a hand. 2  Difficulty walking. 3  Clumsiness of the hands. 4  Fasciculations, which are subtle, light twitches under the skin.  Impaired speech.