what causes liver and spleen swelling 1 One of the most likely causes of an enlarged spleen is an infection, since swelling in the spleen signifies an increase in white blood cells that are trying to attack something threatening. 2  Leishmaniasis, a type of parasitic disease found in parts of the tropics, subtropics and southern Europe, can lead to an enlarged spleen. more information...
Yes, you can use acetaminophen and ibuprofen together. That combination of drugs controls very high fever in children. You need to know that they are not the similar drugs. Ibuprofen is one of the nonsteroidal anti-inflammatory drugs.
In this instance, it's okay to give acetaminophen a try now. In fact, because you can't give her ibuprofen again for six to eight hours after the first dose, it may be helpful to try a new tack. If the acetaminophen does the trick, your child won't need any medication at all for another six to eight hours. It's not a good idea, though, to get in the habit of giving your child alternating doses of ibuprofen and acetaminophen, because ongoing alternating doses can be hard on the kidneys.