A regulatory framework Although common in other process manufacturing industries (e.g., food and chemicals), continuous processing is at a nascent stage in the pharmaceutical industry, where batch manufacturing is the prevailing mode.
When the motor neurons in the brainstem are affected (bulbar ALS), the muscles used in speech and swallowing are impaired. ALS only affects muscles that are moved voluntarily (such as those in the mouth or arm) and does not impact those muscles involved in involuntary movements, such as digestion.
The early onset of ALS is often very subtle-these are the first Symptoms of ALS to watch for: 1  twitching and cramping of the muscles, especially those in the hands and feet. 2  muscle weakness in the arms or legs. 3  loss of motor control in the arms or legs. 4  general weakness and fatigue. 5  tripping and falling. 6  dropping things.