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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Metformin Side Effects. In Summary. Commonly reported side effects of metformin include: lactic acidosis, diarrhea, nausea, vomiting, nausea and vomiting, and flatulence. Other side effects include: diarrhea, nausea, vomiting, decreased vitamin b12 serum concentrate, and weakness. See below for a comprehensive list of adverse effects.