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Researchers have determined that Werner Syndrome is caused by abnormal changes (mutations) of a gene (known as the WRN gene) located on the short arm of chromosome 8 (8p12-11.2).* More than 80 different mutations of the WRN gene have been identified in individuals with the disorder.ymptoms of the following disorders can be similar to those of Werner Syndrome. Comparisons may be useful for a differential diagnosis: Hutchinson-Gilford Progeria Syndrome is a very rare disorder of childhood characterized by premature aging, short stature, and characteristic facial features.
Knowledge center. Wernicke-Korsakoff syndrome is directly caused by a thiamin deficiency and is linked to long-term (chronic) alcohol consumption-however, some patients who do not abuse alcohol may also develop this syndrome.ernickes encephalopathy-this is a type of brain damage in which the initial symptoms appear. The individual has abnormal gait and eye movements. Korsakoff syndrome-if Wernickes encephalopathy is left untreated the patient will start developing this psychiatric disorder, which includes dementia and psychosis.