anything done or to be done; anything requiring action or effort; business; concern: an affair of great importance. 2. affairs, matters of commercial or public interest or concern; the transactions of public or private business or finance:
Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis, whereas lactic acidosis is characterized by persistently increased blood lactate levels (usually >5 mmol/L) in association with metabolic acidosis.
In this study, a 10% decrease in lactate levels during the 6-h study period was related to an 11% decrease in the likelihood of mortality. Furthermore, 29% of the patients that did not show a decrease in lactate levels during the study did not have hypotension, where the mortality in this group still exceeded 55% [11].