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Most people who have piriformis syndrome get better with treatment and lifestyle changes. Failure to treat this condition can lead to permanent nerve damage, so be sure to follow your doctorâs instructions.
Piriformis Syndrome Video. There is no simple diagnostic test for piriformis syndrome causing irritation of the sciatic nerve. The condition is primarily diagnosed on the basis of the patientâs symptoms and on a physical exam, and after excluding other possible causes of the patientâs pain.ymptoms of Piriformis Syndrome. Most commonly, patients describe acute tenderness in the buttock and sciatica-like pain down the back of the thigh, calf and foot. Typical piriformis syndrome symptoms may include: 1  A dull ache in the buttock. 2  Pain down the back of the thigh, calf and foot (sciatica).