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Researchers have determined that Werner Syndrome is caused by abnormal changes (mutations) of a gene (known as the WRN gene) located on the short arm of chromosome 8 (8p12-11.2).* More than 80 different mutations of the WRN gene have been identified in individuals with the disorder.ymptoms of the following disorders can be similar to those of Werner Syndrome. Comparisons may be useful for a differential diagnosis: Hutchinson-Gilford Progeria Syndrome is a very rare disorder of childhood characterized by premature aging, short stature, and characteristic facial features.
It is believed that the genes affected by Werner Syndrome are prevented from reco,mbining, replication and repair. People living with Werner Syndrome may have a lot of tumors, thyroid tumors and soft tissue sarcomas and meningioma's.ost cancers affect epithelial tissue, but those that onset because of Werner Syndrome are just as likely to appear in the connective tissue and muscle. Unusually, the cancers that are seen the most often with this condition usually affect children but are present in adults with the condition in their 40s and 50s.