22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
And it's a glorious occasion that he envisions, with 813 animal guests, a room full of presents (you can lift the flaps to open some), balloons that rise and a firecracker-favor that snaps, pop-up ice cream and cake, and a baton-waving conductor to lead the Happy Birthday chorus.