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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
It may be more effective than acetaminophen for inflammatory pain, such as that associated with arthritis. The current recommended daily dose of ibuprofen is 1,200 mg (1.2 g). As with most NSAIDs, ibuprofen can increase the risk of stomach ulcers and gastrointestinal bleeding in patients.