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While spaying is traditionally recommended for kitties between 4 and 6 months of age, spaying as young as 8 weeks old is considered safe, according to Cat Channel. Many animal shelters actually spay kitties prior to adopting them out at this age.
The kittens were divided into three groups: 1  Group 1 (11 kittens) were neutered or spayed at 7 weeks of age. 2  Group 2 (11 kittens) were neutered or spayed at 7 months. 3  Group 3 (the control group of 9 kittens) were not neutered until maturity and after the completion of the first phase of the study at 12 months.