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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
A new study suggests that taking ibuprofen, the common non-steroidal anti-inflammatory drug (or NSAID), increases your risk of heart attack or stroke by more than a third. But before you rush to the bathroom cabinet to throw out every painkiller you've ever owned, read on for the whole picture.