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In its early stages, some of the symptoms of ALS can be similar to those of MS. These include: Stiff, weak muscles; Twitching or spasms; Fatigue; Trouble walking; If youâre having these symptoms, donât try to guess what's going on. See a doctor and get a diagnosis. As ALS attacks the nerves that deal with movement, your symptoms will get worse.
The onset of ALS/MND may be so subtle that symptoms are overlooked or misread. The earliest symptoms may include: 1  Muscle weakness. 2  Muscle twitches (fasciculations). 3  Cramps and/or tight and stiff muscles (spasticity). 4  Muscle loss and/or atrophy. 5  Slurred and nasal speech. 6  Difficulty chewing and swallowing. 7  Excessive choking. 8  Excessive shortness of breath. 9  Unintended weight loss.