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Long-term treatment with ibuprofen at a dose of 1200 mg/day does not increase the risk of renal impairment in elderly people (Griffin et al, 2000). Ibuprofen is associated with a low risk of renal toxicity in overdose (Jenkinson et al, 1988; Volans and Fitzpatrick, 1999).
Medical Definition of Ibuprofen. Ibuprofen: A nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to treat pain, swelling, and fever. Common brand names of ibuprofen include Advil, Motrin, and Nuprin. Last Editorial Review: 5/13/2016.