what causes liver and spleen swelling 1 One of the most likely causes of an enlarged spleen is an infection, since swelling in the spleen signifies an increase in white blood cells that are trying to attack something threatening. 2  Leishmaniasis, a type of parasitic disease found in parts of the tropics, subtropics and southern Europe, can lead to an enlarged spleen. more information...
Do not take Tylenol and ibuprofen together if you are taking any other medications for pain without first checking with a doctor. Some medicines, like cold medicine, contain ibuprofen or acetaminophen, and taking more puts you at risk for an overdose.
Take only the recommended dose of Tylenol, and do not take it with other medicines containing acetaminophen. In rare cases, an overdose of acetaminophen can cause liver failure and death. Wait another four hours. After eight hours from your first dose of ibuprofen, take another dose of ibuprofen.