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Nephrotic syndrome is characterized by large proteinuria (>3.5 g per 1.73 m2 body surface area per day, or > 40 mg per square meter body surface area per hour in children), hypoalbuminemia (< 2,5 g/dl), hyperlipidaemia, and edema (which is generalized and also known as anasarca or dropsy) that begins in the face.
As a result, fluid builds up in the tissues and causes swelling. Nephrotic syndrome is often caused by: A type of kidney disease called minimal change disease (or nil disease). This is the main cause of nephrotic syndrome in children. Doctors don't know what causes minimal change disease. Diabetes. This is the most common cause of nephrotic syndrome in adults.