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Most people who have piriformis syndrome get better with treatment and lifestyle changes. Failure to treat this condition can lead to permanent nerve damage, so be sure to follow your doctorâs instructions.
Piriformis Syndrome: Related Medical Conditions. To research the causes of Piriformis Syndrome, consider researching the causes of these these diseases that may be similar, or associated with Piriformis Syndrome: 1  Sciatica. 2  Neuropathy. 3  Overuse injury. 4  NSAIDs.5  Physical therapy.6  Osteopathic manipulative medicine.iriformis Syndrome: Related Medical Conditions. To research the causes of Piriformis Syndrome, consider researching the causes of these these diseases that may be similar, or associated with Piriformis Syndrome: 1  Sciatica. 2  Neuropathy. 3  Overuse injury. 4  NSAIDs.