anything done or to be done; anything requiring action or effort; business; concern: an affair of great importance. 2. affairs, matters of commercial or public interest or concern; the transactions of public or private business or finance:
Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis, whereas lactic acidosis is characterized by persistently increased blood lactate levels (usually >5 mmol/L) in association with metabolic acidosis.
In humans (n = 10) infused with 1.0â1.3 mmol sodium dl-lactate/(kg Â· h), â¼90% of d-lactate was metabolized, and 10% excreted in the urine (12). At higher infusion rates of 3.0â4.6 mmol/(kg Â· h), metabolism decreased to â¼75% of overall clearance (12).