A regulatory framework Although common in other process manufacturing industries (e.g., food and chemicals), continuous processing is at a nascent stage in the pharmaceutical industry, where batch manufacturing is the prevailing mode.
When the motor neurons in the brainstem are affected (bulbar ALS), the muscles used in speech and swallowing are impaired. ALS only affects muscles that are moved voluntarily (such as those in the mouth or arm) and does not impact those muscles involved in involuntary movements, such as digestion.
Regardless of the part of the body where ALS first makes an appearance, muscle weakness and atrophy eventually spread as the disease progresses. Later symptoms may include: 1  shortness of breath. 2  difficulty breathing. 3  difficulty swallowing.rogressive Symptoms of ALS. Regardless of the part of the body where ALS first makes an appearance, muscle weakness and atrophy eventually spread as the disease progresses. Later symptoms may include: 1  shortness of breath. 2  difficulty breathing. 3  difficulty swallowing. 4  difficulty chewing. 5  tight and stiff muscles.