anything done or to be done; anything requiring action or effort; business; concern: an affair of great importance. 2. affairs, matters of commercial or public interest or concern; the transactions of public or private business or finance:
Hyperlactatemia is defined as a persistent, mild to moderate (2-4 mmol/L) increase in blood lactate concentration without metabolic acidosis, whereas lactic acidosis is characterized by persistently increased blood lactate levels (usually >5 mmol/L) in association with metabolic acidosis.
When the BUN level is considered dangerous? If your creatinine level is higher than 20 mg/dL, your kidneys may not be working at full strength. However, to judge whether certain BUN level is dangerous depends on many factors. Compared with BUN, creatinine is a better indicator of kidney function. If your creatinine level remains stable but BUN level increases, this could be due to dehydration, a large amount of protein intake or intestinal tract bleeding.