1 A person may or may not have any symptoms previously, but all of the sudden a plaque ruptures, triggering a chain of events and a sudden heart attack.  The other is a more gradual progression of coronary disease. In these patients, an artery is getting narrower over time.
Knee pain at night causes. Common causes of knee pain at night include sprains and strains, anterior knee pain, menisci or cartilage damage, osteoarthritis tendonitis, bursitis, torn ligaments or tendons, bleeding into the joint, Osgood Shatlerâs disease, gout, septic arthritis, overuse, and obesity.
Nighttime Leg Cramps: Meds That Hurt, Meds That Help. Nocturnal leg cramps are a common cause of pain in the legs that can disrupt sleep. They are present in nearly 50 percent of those over the age of 50. Leg cramps are characterized by sudden muscle tightness, most commonly in the foot, thigh, or calf, that may last from seconds to minutes.