22q11.2 deletion syndrome is caused by the deletion of a small section of chromosome 22. It results in a cleft palate, heart defects, autoimmune disorders, and more. The symptoms vary wildly and can be accompanied by learning disabilities and mental illness. Cystic fibrosis is caused by a point deletion.
The melody of Happy Birthday to You comes from the song  Good Morning to All , which has been attributed to American siblings Patty Hill and Mildred J. Hill in 1893, although the claim that the sisters composed the tune is disputed.
Today the song brings in $2 million a year in royalties ($5000 per day). It costs $25,000 to use the song in a movie or TV show which explains why you often see actors sing an odd, amalgamated version on screen.This also explains why chain restaurants sing their own custom songs for a guest's birthday.stimated earnings: $50 million. In 1893, the Hill sisters needed a song for their kindergarten class to sing on birthdays. Fast forward 120 years and Happy Birthday is by far the richest and most profitable song of all time. The Ownership of Happy Birthday has changed hands a few times in the last 100 years.