You also need. to know if the pilot wants to combine the flight review with a new endorsement or. aircraft checkout. Offer an initial estimate of how much time to plan for ground and. flight training. How much time is âenoughâ will vary from pilot to pilot. Someone who. flies the same airplane 200 hours every year may not need as much time as someone. who has logged only 20 hours since the last flight review, or a pilot seeking a new. endorsement in conjunction with the flight review.
Grapefruit products, such as grapefruit, grapefruit juice, or grapefruit supplements, can interact with some cholesterol-lowering statins and increase the level of medication in your blood. LipitorÂ® (atorvastatin calcium) is one of these statins.
Drugs or toxins are broken down (metabolized) so that they can be eliminated from the body. Grapefruit juice decreases the activity of the cytochrome P450 3A4 (CYP3A4) enzymes that are responsible for breaking down many drugs and toxins. Grapefruit contains compounds known as furanocoumarins that block the CYP3A4 enzymes. When grapefruit juice is consumed, the enzymeâs ability to break down the drug for elimination is decreased. Blood levels of the drug may rise, resulting in the risk for new or worsened side effects.