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Metaphase is when the chromosomes attach to the spindle fibers by their centromeres. This can be confused with the phases:prophase where the spindle fibers form a bridge between the ends of the cell, and anaphase where the spindle fibers draw the chromosomes to the opposite ends of the cell(the cell splits up) Report.
Written By: Centromere, structure in a chromosome that holds together the two chromatids (the daughter strands of a replicated chromosome). The centromere is the point of attachment of the kinetochore, a structure to which the microtubules of the mitotic spindle become anchored. The spindle is the structure that pulls the chromatids to opposite ends of the cell during the cell division processes of mitosis and meiosis.