A regulatory framework Although common in other process manufacturing industries (e.g., food and chemicals), continuous processing is at a nascent stage in the pharmaceutical industry, where batch manufacturing is the prevailing mode.
When the motor neurons in the brainstem are affected (bulbar ALS), the muscles used in speech and swallowing are impaired. ALS only affects muscles that are moved voluntarily (such as those in the mouth or arm) and does not impact those muscles involved in involuntary movements, such as digestion.
â¢ Classical ALS-The most common form of this syndrome. The individual experiences a progressive deterioration of the nerve cells and experience loss of motor function in hands, feet, arms, and legs, in addition to difficulty chewing, speaking, and swallowing.he nerve damage is isolated to one type of nerve and symptoms are generally confined to loss of motor function in hands, feet, arms, and legs. â¢ Progressive Bulbar Palsy (PBP) - Affects about 25 percent of the people afflicted with ALS.