Phosphorylation of signal transduction molecules is a major activating event that leads to dramatic changes in tumor growth. Some TKs, such as epidermal growth factor receptor (EGFR)-TK, can autophosphorylate when activated, as well as phosphorylating other signaling molecules [2].
Risk indexes Definition: Categories of risk used to calculate fundamental beta, including (1) market variability, (2) earnings variability, (3) low valuation, (4) immaturity and smallness, (5) growth orientation, and (6) financial risk.
The company-specific risk premium is added when the company is more risky in the remaining market. The enterprise equity discount (yield) rate includes three elements: (1) a market-derived, risk-free rate of return; (2) a general (equity) risk premium derived from the public equity markets; and (3) a company-specific risk adjustment.