The ossicles are classically supposed to mechanically convert the vibrations of the eardrum, into amplified pressure waves in the fluid of the cochlea (or inner ear) with a lever arm factor of 1.3.
1 In 2008, research on marijuanaâs risk to health commissioned by nonpartisan British think tank the Beckley Foundation found: âThe public health impact of contemporary patterns of cannabis use are modest by comparison with those of other illicit drugs (such as the opioids) or with alcohol. In 2002, an exhaustive review of marijuana and health performed by a special Canadian Senate committee found that âscientific evidence overwhelmingly indicates that cannabis is substantially less harmful than alcohol and should be treated not as a criminal issue but as a social and public health issue.â.
However, many systems in the brain are interrelated. It's not clear if alcohol directly acts on all those receptors or if they're a downstream result of its action elsewhere. The smoking gun would be to isolate a receptor and show that alcohol affects it. If alcohol is a depressant, it should facilitate GABA receptors. When GABA receptors were first isolated, they did respond to alcohol, but not until alcohol concentrations reached .33 mL/L. The legal limit for driving is .08 mL/L.