Actinic keratoses that develop on the lips are referred to as actinic cheilitis. The clinical appearance of an actinic keratosis is that of a small (several millimeters), red scaly papule or plaque, with induration and thickening of the epidermis.
1 Location: Ideally, the probe should be in close proximity to the forward or reverse primer, but should not overlap with a primer-binding site on the same strand. 2  Probes can be designed to bind to either strand of the target. 3  Melting temperature (Tm): Preferably, probes should have a Tm 6â8Â°C higher than the primers.
Now, a probe is on a seven-hour journey to land on 67P, the comet shaped like a rubber duck that Rosetta has been chasing around the solar system like a cosmic pingpong ball for 10 years. Commander Captain Kirk -- prompting the actor who played him, William Shatner, to send his best wishes.