A regulatory framework Although common in other process manufacturing industries (e.g., food and chemicals), continuous processing is at a nascent stage in the pharmaceutical industry, where batch manufacturing is the prevailing mode.
When the motor neurons in the brainstem are affected (bulbar ALS), the muscles used in speech and swallowing are impaired. ALS only affects muscles that are moved voluntarily (such as those in the mouth or arm) and does not impact those muscles involved in involuntary movements, such as digestion.
The metabolic effects usually associated with the lipodystrophy syndrome include: 1  Fat redistribution, including lipohypertrophy (central) and lipoatrophy (predominantly face and lower limbs). 2  Insulin resistance (hyperglycaemia). 3  Dyslipidaemia (raised total cholesterol and triglycerides, lowered high-density lipoprotein (HDL) cholesterol).