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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
No Evidence L-Arginine Lowers Blood Pressure in Humans. There is no evidence that arginine supplementation has any beneficial effects on blood pressure in humans. In fact, it is likely that taking arginine supplements wouldnât have any effect at all.