1 Globally, an estimated 350 million people of all ages suffer from depression. 2  Depression is the leading cause of disability worldwide, and is a major contributor to the overall global burden of disease. 3  More women are affected by depression than men.  At its worst, depression can lead to suicide.
Low-temperature cooking. Low-temperature cooking is a cooking technique using temperatures of 45 to 85 Â°C (113 to 185 Â°F) for a prolonged time to cook food.
Place the loaf into the bottom of a 5 or 6 quart slow cooker. Cover and allow the meat loaf to cook on high for 1 hour and then finish cooking on low for 2 to 4 more hours. Or, cook on low for 4 to 6 hours. When properly done, the meat should have an internal temperature of at least 145Â°F.