A regulatory framework Although common in other process manufacturing industries (e.g., food and chemicals), continuous processing is at a nascent stage in the pharmaceutical industry, where batch manufacturing is the prevailing mode.
When the motor neurons in the brainstem are affected (bulbar ALS), the muscles used in speech and swallowing are impaired. ALS only affects muscles that are moved voluntarily (such as those in the mouth or arm) and does not impact those muscles involved in involuntary movements, such as digestion.
Over time, as the muscles of the body break down, someone living with ALS will lose the ability to walk, talk, eat, swallow, and eventually breathe. ALS is not contagious. There are no effective treatments for ALS and no cure. Approximately 80 per cent of people with ALS die within two to five years of being diagnosed.