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They can weigh anywhere from 110 pounds to the 343 pounds of Zorba, the world's largest dog, although most Mastiff males weigh around 160-230 pounds and females around 120-170 pounds.
The biggest weight for a dog ever recorded was an English mastiff named Aicama Zorba, who weighed in at 343 pounds. Their size is a significant part of the breed's past purpose, which included blood sports such as baiting bears, bulls and lions.