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L-arginine has unpredictable effects on insulin and cholesterol-lowering agents. L-arginine may increase the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate and sodium nitroprusside. Side Effects. L-arginine has few reported adverse reactions. Nausea and diarrhea have been reported infrequently.
Most persons prescribed Hydergine experience little in the way of serious side effects. Some minor effects that were reported include: nasal congestion, nausea and gastric problems (these effects may be reduced if the medication is taken with food), an allergic reaction of the skin, headache, or blurred vision.