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What is the Hardy-Weinberg principle and under what conditions does this principle apply? The Hardy-Weinberg principle states that in a large randomly breeding population, allelic frequencies will remain the same from generation to generation assuming that there i â¦ s no mutation, gene migration, selection or genetic drift.
To explore the Hardy-Weinberg equation, we can examine a simple genetic locus at which there are two alleles, A and a. The Hardy-Weinberg equation is expressed as: p 2 + 2pq + q 2 = 1. where p is the frequency of the A allele and q is the frequency of the a allele in the population.In the equation, p 2 represents the frequency of the homozygous genotype AA, q 2 represents the frequency of the homozygous genotype aa, and 2pq represents the frequency of the heterozygous genotype Aa.In addition, the sum of the allele frequencies for all the alleles at the locus must be 1, so p + q = 1.If the p and q allele frequencies are known, then the frequencies of the three genotypes may be calculated using the Hardy-Weinberg equation.n addition, the sum of the allele frequencies for all the alleles at the locus must be 1, so p + q = 1. If the p and q allele frequencies are known, then the frequencies of the three genotypes may be calculated using the Hardy-Weinberg equation.