A regulatory framework Although common in other process manufacturing industries (e.g., food and chemicals), continuous processing is at a nascent stage in the pharmaceutical industry, where batch manufacturing is the prevailing mode.
When the motor neurons in the brainstem are affected (bulbar ALS), the muscles used in speech and swallowing are impaired. ALS only affects muscles that are moved voluntarily (such as those in the mouth or arm) and does not impact those muscles involved in involuntary movements, such as digestion.
Gradual onset and painless, progressive muscle weakness is the most common early ALS symptom. Other early symptoms of ALS vary, but may include tripping, dropping things, abnormal fatigue of the arms or legs, slurred speech, muscle cramps and twitches, and/or ... Lou Gehrig's Disease: Early Symptoms www.lifescript.com/health/briefs/l/lou_gehrigs_disease_early_symptoms.aspx. about.