what causes liver and spleen swelling 1 One of the most likely causes of an enlarged spleen is an infection, since swelling in the spleen signifies an increase in white blood cells that are trying to attack something threatening. 2  Leishmaniasis, a type of parasitic disease found in parts of the tropics, subtropics and southern Europe, can lead to an enlarged spleen. more information...
Do not take Tylenol and ibuprofen together if you are taking any other medications for pain without first checking with a doctor. Some medicines, like cold medicine, contain ibuprofen or acetaminophen, and taking more puts you at risk for an overdose.
Generally, there are very few reasons for taking the 2 medications together. However, for one night, it would be okay to use the 2 together as long as the total daily dose of acetaminophen (Tylenol) does not go over 4 grams (4000mg). Longer use of the two medications together would not be suggested.