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Researchers have determined that Werner Syndrome is caused by abnormal changes (mutations) of a gene (known as the WRN gene) located on the short arm of chromosome 8 (8p12-11.2).* More than 80 different mutations of the WRN gene have been identified in individuals with the disorder.ymptoms of the following disorders can be similar to those of Werner Syndrome. Comparisons may be useful for a differential diagnosis: Hutchinson-Gilford Progeria Syndrome is a very rare disorder of childhood characterized by premature aging, short stature, and characteristic facial features.
In some cases, hereditary factors may cause some individuals to have a genetic predisposition to developing Wernicke-Korsakoff syndrome. However, more research is necessary to determine what role, if any, genetics plays in the development of the disorder. The symptoms of Wernicke-Korsakoff syndrome occur due to a deficiency of thiamine. Although thiamine is a nutrient required by all the tissues of the body, thiamine deficiency affects the cells of the nervous and cardiovascular systems to a greater degree than the cells of other organ systems.