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NSAIDs are also used to treat non-inflammatory conditions such as migraine, period pain and postoperative pain, and to reduce fever. Aspirin is an NSAID with âblood-thinningâ properties. It can be used in low doses to reduce the risk of heart attack and stroke in high-risk patients.
NSAIDs can cause serious side effects, including: 1  Increased risk of a heart attack or stroke that can lead to death. 2  Increased risk of bleeding, ulcers, and tears (perforation) of the esophagus (tube leading from the mouth to the stomach), stomach and intestines: anytime during use.