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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
When your skin is injured or broken, platelets clump together and form clots to stop the bleeding. When you do not have enough platelets in your blood, your body cannot form clots. A low platelet count may also be called thrombocytopenia. This condition can range from mild to severe, depending on its underlying cause.For some, symptoms can include severe bleeding and are possibly fatal if not treated.f your bone marrow is not producing enough platelets, you will have a low platelet count. Causes of low platelet production include: 1  aplastic anemia. 2  vitamin B12 deficiency. 3  folate (iron) deficiency. 4  viral infectionsâincluding the human immunodeficiency virus (HIV), Epstein-Barr virus, and chicken pox.