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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
What is a low platelet count? A low platelet count occurs when there is a lower than average amount of platelets, blood cells that aid in blood clotting, in someone's blood, according to Mayo Clinic. The medical term for a low platelet count is thrombocytopenia.