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Although it is no bigger than a pea, the pituitary gland, located at the base of the brain just beneath the hypothalamus, is considered the most important part of the endocrine system. It's often called the master gland because it makes hormones that control several other endocrine glands.
The endocrine pancreas is regulated by hormonal activity controlled by the hypothalamus. The dysfunction of the regulation of islet hormone secretion as well as its mechanisms and the pathophysiology of the islet dysfunction is primarily a breakdown in the neuroendocrine control.