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Although it is no bigger than a pea, the pituitary gland, located at the base of the brain just beneath the hypothalamus, is considered the most important part of the endocrine system. It's often called the master gland because it makes hormones that control several other endocrine glands.
The endocrine system regulates the metabolism and development of most body cells and body systems through feedback mechanisms. For example, Thyrotropin-Releasing Hormone (TRH) and Thyroid Stimulating Hormone (TSH) are controlled by a number of negative feedback mechanisms.