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Certain heart diseases. Heart diseases, including aortic valve disease, left heart failure, mitral valve disease, and congenital heart disease, can also cause pulmonary hypertension. Thromboembolic disease. A blood clot in a large pulmonary artery can result in the development of pulmonary hypertension.
Development of COPD with Pulmonary Hypertension. Pulmonary hypertension is often a result of COPD and is associated with increased risks of exacerbation and decreased survival, according to the study, â Pulmonary hypertension in COPD, â published in 2008.