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Although it is no bigger than a pea, the pituitary gland, located at the base of the brain just beneath the hypothalamus, is considered the most important part of the endocrine system. It's often called the master gland because it makes hormones that control several other endocrine glands.
The hypothalamus controls most endocrine activity in three ways. (similar to below) 1. Controls release of regulatory hormones from the anterior pituitary gland. 2. Secretes oxytocin (OT) and antidiuretic hormone (ADH) which are stored and released from the posterior pituitary gland.