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Irritating Skin Rashes: 13 Possible Causes. Not typically serious, but always irritating and embarrassing, skin rashes can be caused by a number of factorsâsuch as environment, infection, stress, heat, allergens, immune system disorders, and medication.
1 Drugs. 2  Reactions to drugs, such as antibiotics, antifungal drugs or narcotic pain medications, can cause widespread rashes and itching. 3  Pregnancy. 4  During pregnancy, some women experience itchy skin, especially on the abdomen, thighs, breasts and arms. Drugs. 2  Reactions to drugs, such as antibiotics, antifungal drugs or narcotic pain medications, can cause widespread rashes and itching. 3  Pregnancy. 4  During pregnancy, some women experience itchy skin, especially on the abdomen, thighs, breasts and arms.