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The following are some known causes of pulmonary hypertension: 1  The diet drug fen-phen.. Although the appetite suppressant fen-phen (dexfenfluramine and phentermine) has been taken off the market, former fen-phen users have a 23-fold increase risk of developing pulmonary hypertension, possibly years later.
While no cure currently exists for pulmonary hypertension, some treatments approved by the U.S. Food and Drug Administration (FDA) are designed to accompany behavioral alterations to help patients cope with the disease. Exercise is one of the behavioral alterations.