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A Stacy Wiegman, PharmD , Pharmacy, answered. Zofran (ondansetron) acts fairly quickly. For people who are undergoing chemotherapy, it is usually given 30 minutes before starting the chemo so that it is working when chemo starts. To prevent nausea and vomiting after surgery, it is usually given one hour before the operation.
Zofran is used to prevent nausea and vomiting due to chemotherapy treatment or surgery. It may also be used for other conditions as determined by a doctor. Zofran is a serotonin 5-HT3 receptor blocker. It works by blocking a chemical that causes nausea and vomiting in certain incidents (eg, chemotherapy)