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Certain heart diseases. Heart diseases, including aortic valve disease, left heart failure, mitral valve disease, and congenital heart disease, can also cause pulmonary hypertension. Thromboembolic disease. A blood clot in a large pulmonary artery can result in the development of pulmonary hypertension.
Causes of pulmonary hypertension. The changes in the pulmonary arteries that lead to pulmonary hypertension can be caused by: problems with the smaller branches of the pulmonary arteries (PAH) conditions that affect the left side of the heart. lung diseases or a shortage of oxygen in the body (hypoxia)