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Irritating Skin Rashes: 13 Possible Causes. Not typically serious, but always irritating and embarrassing, skin rashes can be caused by a number of factorsâsuch as environment, infection, stress, heat, allergens, immune system disorders, and medication.
Other Causes. 1  Certain skin allergies can also lead to red rash all over body. The skin is the first site where most allergic reactions are manifested, and are known as dermatitis. 2  Autoimmune diseases such as psoriasis cause lesions to appear on the skin, including the scalp, elbows, knees, lower back and the buttocks area.