1 The first bomb dropped on Hiroshima was made from uranium. 2  The bomb dropped on Nagasaki was made from plutonium, which was even more powerful than uranium. 3  It is thought that at least 135,000 people died from the Hiroshima explosion and another 70,000 in Nagasaki.
Pharmacokinetic parameters of paclitaxel following 3- and 24-hour infusions of TAXOL at dose levels of 135 and 175 mg/m2 were determined in a Phase 3 randomized study in ovarian cancer patients and are summarized in the following table.
5. Schematic diagram of the fractional precipitation and the results obtained for the pre-purification of paclitaxel from biomass. The methanol concentration in water, paclitaxel content in the crude extract, storage temperature, and storage time were 61.5% (v/v), 0.5% (w/v), 0 Â°C, and 3 days, respectively.n this study, the storage temperature, an important process variable in fractional precipitation, was optimized in terms of the yield and purity of paclitaxel for a fixed methanol concentration in water (61.5%, v/v), paclitaxel content in the crude extract (0.5%, w/v), and storage time (3 days).