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A Stacy Wiegman, PharmD , Pharmacy, answered. Zofran (ondansetron) acts fairly quickly. For people who are undergoing chemotherapy, it is usually given 30 minutes before starting the chemo so that it is working when chemo starts. To prevent nausea and vomiting after surgery, it is usually given one hour before the operation.
Though Zofran was originally created in 1984 to treat nausea and vomiting in cancer patients after receiving chemotherapy, the drug is most commonly used today by pregnant women. It metabolizes in the liver and has a shelf-life of five to seven hours. Common side effects of the drug are headaches and sometimes constipation.