Treatment is usually curative with wide-margin surgical excision but due to the malignant nature of these tumors, recurrence should be considered and regular monitoring is recommended. 1  Gianella P et al (2012) Primary cutaneous undifferentiated round cell tumor with concurrent polymyositis in a dog. Can Vet J 53(5):549-553. Mackowiak II et al (2012) E-cadherin in canine mast cell tumors: Decreased expression and altered subcellular localization in Grade 3 tumors. Vet J 194(3):405-11.
Endocrine glands are glands of the endocrine system that secrete their products, hormones, directly into the blood rather than through a duct.The major glands of the endocrine system include the pineal gland, pituitary gland, pancreas, ovaries, testes, thyroid gland, parathyroid gland, hypothalamus and adrenal glands.The hypothalamus and pituitary gland are neuroendocrine organs.Local chemical messengers, not generally considered part of the endocrine system, include autocrines, which act on the cells that secrete them, and paracrines, which act on a different cell type nearby.he hypothalamus and pituitary gland are neuroendocrine organs. Local chemical messengers, not generally considered part of the endocrine system, include autocrines, which act on the cells that secrete them, and paracrines, which act on a different cell type nearby.
Insulin and glucagon are hormones secreted by islet cells within the pancreas. They are both secreted in response to blood sugar levels, but in opposite fashion! Insulin is normally secreted by the beta cells (a type of islet cell) of the pancreas.The stimulus for insulin secretion is a HIGH blood glucose...it's as simple as that! Although there is always a low level of insulin secreted by the pancreas, the amount secreted into the blood increases as the blood glucose rises.n response to insulin, these cells absorb glucose out of the blood, having the net effect of lowering the high blood glucose levels into the normal range. Glucagon is secreted by the alpha cells of the pancreatic islets in much the same manner as insulin...except in the opposite direction.