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Dexmedetomidine. DEXMEDETOMIDINE (PrecedexÂ®) is an anesthetic agent used to reduce anxiety and tension, and promote relaxation and sedation in patients needing a mechanical ventilator.Dexmedetomidine is administered to patients only by health care professionals in an intensive care or surgical area.exmedetomidine is for injection into a vein. It is given by trained health care professionals in an intensive care or surgical area. Contact your pediatrician or health care professional regarding the use of this medicine in children.