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Certain heart diseases. Heart diseases, including aortic valve disease, left heart failure, mitral valve disease, and congenital heart disease, can also cause pulmonary hypertension. Thromboembolic disease. A blood clot in a large pulmonary artery can result in the development of pulmonary hypertension.
Pulmonary Arterial Hypertension. Pulmonary arterial hypertension (PAH) is a rare form of high blood pressure. It occurs in the pulmonary arteries that flow from your heart and through your lungs. Constricted and narrowed arteries prevent your heart from pumping adequate blood. When constriction occurs, the heart will need to work harder to compensate.