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Irritating Skin Rashes: 13 Possible Causes. Not typically serious, but always irritating and embarrassing, skin rashes can be caused by a number of factorsâsuch as environment, infection, stress, heat, allergens, immune system disorders, and medication.
Common causes of rashes include: 1  Food allergy. 2  Medication side effects. 3  Anxiety. 4  Allergies, for example to food, dyes, medicines, insect stings, metals such as zinc or nickel; such rashes are often called hives. 5  Skin contact with an irritant Fungal infection, such as ringworm. Balsam of Peru. 6  Reaction to vaccination.