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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
A low platelet count is below 150,000. If you do not have enough platelets, you may bleed too much. If your platelet count is below 50,000, your risk of bleeding is much higher. Even every day activities can cause bleeding. If your platelets are low, you need to know how to prevent bleeding and what to do if you are bleeding. A lower-than-normal platelet count is called thrombocytopenia. Low platelet count can be divided into 3 main causes: 1  Not enough platelets are being made in the bone marrow.  Platelets are being destroyed in the bloodstream.