The finer-size sand and clay which fill the spaces between the larger clasts is often deposited later on top of the large clasts and then sifts down between them to fill the interstitial spaces. The deposition of a chemical cement then binds the sediment into a rock. Conglomerate has very few commercial uses.
The brain is particularly sensitive to changes in the sodium level in blood. Therefore, symptoms of brain dysfunction, such as sluggishness (lethargy) and confusion, occur first. If the sodium level in blood falls quickly, symptoms tend to develop rapidly and be more severe.
Some drugs can lower blood sodium levels. Examples of these include diuretics (water tablets), desmopressin, and sulfonylureas. When sodium levels in the body are low, water tends to enter cells, causing them to swell. When this occurs in the brain, it is referred to as cerebral oedema.