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Irritating Skin Rashes: 13 Possible Causes. Not typically serious, but always irritating and embarrassing, skin rashes can be caused by a number of factorsâsuch as environment, infection, stress, heat, allergens, immune system disorders, and medication.
Similar to sulfa drugs, Keflex can cause an allergic reaction that results in a skin rash involved in the hives. The release of histamine from mast cells increases the permeability of blood vessels, resulting in swelling of the face, throat, lips and tongue.