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A Stacy Wiegman, PharmD , Pharmacy, answered. Zofran (ondansetron) acts fairly quickly. For people who are undergoing chemotherapy, it is usually given 30 minutes before starting the chemo so that it is working when chemo starts. To prevent nausea and vomiting after surgery, it is usually given one hour before the operation.
It seems that top-of-the-line anti-nausea medication Zofran, used to treat post-surgery and chemotherapy nausea, can be taken safely by pregnant women. Researchers in Denmark reviewed 600,000 cases in which the medication, also called Odansetron, was given to pregnant women.