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Amlodipine is a drug that is used for angina, arrhythmias, chest  pain, and hypertension. It can stay in your system for between 7  and 10 days.   Yes, there's no problem in taking those 2 drugs together. However, Nyquil might contains phenylephrine or pseudoephedrin and this drug might increase blood pressure (froâ¦m 5-10 mmhg).
Amlodipine is processed by your liver. If your liver isnât working well, more of this drug may stay in your body longer. This puts you at risk for side effects. If you have severe liver problems, you may need a lower dose or a different dosing schedule.