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Certain heart diseases. Heart diseases, including aortic valve disease, left heart failure, mitral valve disease, and congenital heart disease, can also cause pulmonary hypertension. Thromboembolic disease. A blood clot in a large pulmonary artery can result in the development of pulmonary hypertension.
If pulmonary hypertension is caused by another condition, such as a heart or lung problem, treatments will focus on the underlying condition. If pulmonary hypertension is caused by blood clots that block the pulmonary arteries, you may be offered anticoagulant medicines to prevent more clots forming.