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A Stacy Wiegman, PharmD , Pharmacy, answered. Zofran (ondansetron) acts fairly quickly. For people who are undergoing chemotherapy, it is usually given 30 minutes before starting the chemo so that it is working when chemo starts. To prevent nausea and vomiting after surgery, it is usually given one hour before the operation.
Zofran has proven to be an effective medication to treat nausea and vomiting, but the medication never gained federal approval for use in pregnant women. Despite the lack of approval, women battling morning sickness took Zofran, Zuplenz (similar drug) or ondansetron (generic version) which some families claim led to birth defects. Zofran is approved to prevent nausea and vomiting caused by chemotherapy, radiation and surgery.