Differentiation is an operation that allows us to find a function that outputs the rate of change of one variable with respect to another variable. Informally, we may suppose that we're tracking the position of a car on a two-lane road with no passing lanes.
Overactive bladder is typically treated with a class of drugs called anticholinergics. Examples include DetrolÂ®, DitropanÂ®, VesicareÂ®, and EnablexÂ®. Mirabegron is a new drug approved for overactive bladder that has a different mechanism of action than the anticholinergics. MECHANISM: Mirabegron (MyrbetriqÂ®) stimulates Beta-3 adrenergic receptors. Stimulation of Beta-3 adrenergic receptors in the bladder muscle causes it to relax.
In a small study of 15 healthy, lean men, Mirabegron was shown to increase basal heart rate, metabolic rate and blood pressure which are signs of cardiovascular stimulation. Recently, mirabegron was shown to relax in vitro human and rabbit prostate smooth muscle through activation of beta3-adrenoceptor.