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The following are some known causes of pulmonary hypertension: 1  The diet drug fen-phen.. Although the appetite suppressant fen-phen (dexfenfluramine and phentermine) has been taken off the market, former fen-phen users have a 23-fold increase risk of developing pulmonary hypertension, possibly years later.
Left heart disease can cause pulmonary hypertension via multiple mechanisms. In the past, a normal ejection fraction and the absence of left-sided valve disease or congenital heart disease provided reassurance that pulmonary hypertension was not related to left-sided heart disease.s the use of agents for IPAH have been expanded to patients with pulmonary hypertension related to connective tissue disease, expansion to use in patients with diastolic heart failure and secondary pulmonary hypertension would be a reasonable avenue for investigation.