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TRUVADA is a type of medicine called a nucleoside analog reverse transcriptase inhibitor (NRTI) that is used to treat HIV-1 infection in adults and teenagers (12 and older). TRUVADA is a combination therapy because it has 2 medicines in 1 pillâ emtricitabine and tenofovir disoproxil fumarate.TRUVADA is always used with other anti-HIV medicines to treat HIV-1 infection because TRUVADA alone is not a complete treatment. In people taking TRUVADA with other HIV-1 medicines to treat HIV-1 infection, common side effects include: diarrhea, nausea, tiredness, headache, dizziness, depression, problems sleeping, abnormal dreams, and rash.