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Certain heart diseases. Heart diseases, including aortic valve disease, left heart failure, mitral valve disease, and congenital heart disease, can also cause pulmonary hypertension. Thromboembolic disease. A blood clot in a large pulmonary artery can result in the development of pulmonary hypertension.
It may be defined as a pulmonary artery systolic pressure greater than 30 mm Hg or a pulmonary artery mean pressure greater than 20 mm Hg. The etiology of primary pulmonary hypertension is unknown. Secondary pulmonary hypertension can be a complication of many pulmonary, cardiac and extrathoracic conditions.rimary pulmonary hypertension is a rare disease of unknown etiology, whereas secondary pulmonary hypertension is a complication of many pulmonary, cardiac and extrathoracic conditions.