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Although it is no bigger than a pea, the pituitary gland, located at the base of the brain just beneath the hypothalamus, is considered the most important part of the endocrine system. It's often called the master gland because it makes hormones that control several other endocrine glands.
The hypothalamus, located just above the brain stem, serves as the link between the endocrine system and the nervous system via the pituitary gland by controlling the pituitary through the stimulation or suppression of hormone secretions.