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Certain heart diseases. Heart diseases, including aortic valve disease, left heart failure, mitral valve disease, and congenital heart disease, can also cause pulmonary hypertension. Thromboembolic disease. A blood clot in a large pulmonary artery can result in the development of pulmonary hypertension.
Although chronic hypoxia is a recognized cause of pulmonary hypertension, it would rarely lead to severe pulmonary hypertension. Nonetheless, patients with advanced chronic obstructive pulmonary disease (COPD) and interstitial lung disease who develop pulmonary hypertension tend to have a worse outcome.