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MDRO definition. For epidemiologic purposes, MDROs are defined as microorganisms, predominantly bacteria, that are resistant to one or more classes of antimicrobial agents (1).imilarly, therapeutic options are limited for ESBL-producing isolates of gram-negative bacilli, strains of A. baumannii resistant to all antimicrobial agents except imipenem(8-11, 38) and intrinsically resistant Stenotrophomonas sp.(12-14, 39).
A multidrug resistant organism (MDRO) is a germ that is resistant to many antibiotics. If a germ is resistant to an antibiotic, it means that certain drug treatments will not work. Examples of MDROs are: 1  Methicillin resistant Staphylococcus aureus (MRSA).