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A Stacy Wiegman, PharmD , Pharmacy, answered. Zofran (ondansetron) acts fairly quickly. For people who are undergoing chemotherapy, it is usually given 30 minutes before starting the chemo so that it is working when chemo starts. To prevent nausea and vomiting after surgery, it is usually given one hour before the operation.
Zofran comes in 4- and 8-milligram (mg) tablets. Zofran ODT comes in 4- and 8-mg orally disintegrating tablets. Zofran also comes in liquid form. To treat or prevent nausea or vomiting, you'll usually take a tablet 30 minutes before chemotherapy, one or two hours before radiation therapy, and one hour before surgery.