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A Stacy Wiegman, PharmD , Pharmacy, answered. Zofran (ondansetron) acts fairly quickly. For people who are undergoing chemotherapy, it is usually given 30 minutes before starting the chemo so that it is working when chemo starts. To prevent nausea and vomiting after surgery, it is usually given one hour before the operation.
Zofran is a powerful anti-nausea drug manufactured and marketed by British pharmaceutical company GlaxoSmithKline. Over the last 25 years, Zofran has become one of Americaâs leading treatments for morning sickness, the sometimes-debilitating nausea and vomiting that affects most pregnant women during the first trimester. But recent research has found Zofran linked to birth defects, including increased risks for congenital heart defects and cleft palate.