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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
The bone marrow does not produce enough platelets. A condition where the body uses and destroys platelets even when the marrow produces enough. A problematic spleen could also deplete the platelets from your blood. Illnesses that damage a personâs stem cells can also be blamed for a low platelet count.