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Although it is no bigger than a pea, the pituitary gland, located at the base of the brain just beneath the hypothalamus, is considered the most important part of the endocrine system. It's often called the master gland because it makes hormones that control several other endocrine glands.
The hypothalamus and hormone control. The hypothalamus is part of the brain and not actually part of the endocrine system. The hypothalamus works with the pituitary gland to control the activity of most of the other glands of the endocrine system. It reacts to changes in the amount of hormones in the body.