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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
A low platelet count, technically known as thrombocytopenia, occurs when the blood loses platelets faster than the bone marrow replaces them. The condition develops from many different underlying causes, and sometimes, no cause can be found.hen low platelets lead to increased bleeding, the problem may appear as tiny hemorrhages on the skin, a condition known as purpura. People with low platelets also bruise more easily, and are likely to have nosebleeds and bleeding gums. A low platelet count tends to cause fatigue and tiredness.