1 The first bomb dropped on Hiroshima was made from uranium. 2  The bomb dropped on Nagasaki was made from plutonium, which was even more powerful than uranium. 3  It is thought that at least 135,000 people died from the Hiroshima explosion and another 70,000 in Nagasaki.
Pharmacokinetic parameters of paclitaxel following 3- and 24-hour infusions of TAXOL at dose levels of 135 and 175 mg/m2 were determined in a Phase 3 randomized study in ovarian cancer patients and are summarized in the following table.
Fractional precipitation is a rapid, simple, and efficient procedure for the pre-purification of paclitaxel with high purity and yield. Here, we report optimization of the storage temperature, a key process variable in fractional precipitation, to obtain paclitaxel of high purity and yield in a pre-purification step.n this study, the storage temperature, an important process variable in fractional precipitation, was optimized in terms of the yield and purity of paclitaxel for a fixed methanol concentration in water (61.5%, v/v), paclitaxel content in the crude extract (0.5%, w/v), and storage time (3 days).