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Total iron binding capacity (TIBC) is a blood test to see if you have too much or too little iron in the blood. Iron moves through the blood attached to a protein called transferrin. This test helps your doctor know how well that protein can carry iron in the blood.
A low TIBC, UIBC, or transferrin may occur if someone has: 1  Hemochromatosis. 2  Certain types of anemia due to accumulated iron. 3  Malnutrition. 4  Inflammation. 5  Liver disease. 6  Nephrotic syndrome, a kidney disease that causes a loss of protein in urine.