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A syndesmosis is defined as a fibrous joint in which two adjacent bones are linked by a strong membrane or ligaments.This definition also applies for the distal tibiofibular syndesmosis, which is a syndesmotic joint formed by two bones and four ligaments.
1 High ankle sprain: The ligament joining the two bones of the lower leg (tibia and fibula), called the syndesmotic ligament, is injured. 2  A high ankle sprain causes pain and swelling similar to a true ankle sprain, but can take longer to heal. 3  Ankle fracture: A break in any of the three bones in the ankle.