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No one really knows what causes asthma. What we do know is that asthma is a chronic inflammatory disease of the airways. The causes of asthma symptoms can vary from person to person. Still, one thing is consistent with asthma: when airways come into contact with an asthma trigger, the airways become inflamed, narrow, and fill with mucus.
In an asthma attack, the air passages of the lungs, known as bronchi, overreact to substances that are ordinarily harmless. Cells in the airways known as mast cells release histamines and leukotrienes, which induce inflammation.These substances prompt the smooth muscles of the airways to go into spasm and constrict.sthma is a condition in which the airways of the lungs narrow in response to environmental triggers (pollens, dust, animal dander, smoke), cold air, exercise, respiratory infection, or emotional distress. Some people suffer asthma attacks as an allergic response to various airborne environmental triggers.