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Although the starting dose for people with panic disorder, post-traumatic stress disorder, or social anxiety disorder is typically 25 mg daily, healthcare providers often increase that dose to 50 mg daily.fter a week, your healthcare provider will likely increase the dose to 50 mg of Zoloft once a day. He or she may also choose to increase the Zoloft dosage if symptoms continue, or decrease the dose if side effects occur.
Most patients tolerate Zoloft well, but it still has side effects that vary in severity. Common side effects of Zoloft are milder than first-generation antidepressants. Minor side effects of Zoloft that typically decrease after the first or second week of use include: 1  Nausea. 2  Diarrhea. 3  Weight loss or gain. 4  Increased sweating. 5  Dizziness. 6  Sleepiness or insomnia. 7  Tremor. 8  Dry mouth.