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The following are some known causes of pulmonary hypertension: 1  The diet drug fen-phen.. Although the appetite suppressant fen-phen (dexfenfluramine and phentermine) has been taken off the market, former fen-phen users have a 23-fold increase risk of developing pulmonary hypertension, possibly years later.
Pulmonary hypertension is diagnosed if the pressure in the right heart catheterization is greater than 25mmHg. Depending on how high the pressure is, the condition may be classified as mild, moderate, or severe pulmonary hypertension.