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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
A normal platelet count in a healthy person ranges from 150,000 to 450,000 platelets per microlitre of blood. When the count is below 150,000 per microlitre, it is considered a low platelet count. There are three possible causes of low platelet count: Presence of platelets in the spleen due to cancer or severe liver diseases. This causes a decrease in the number of platelets in circulation.