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The following are some known causes of pulmonary hypertension: 1  The diet drug fen-phen.. Although the appetite suppressant fen-phen (dexfenfluramine and phentermine) has been taken off the market, former fen-phen users have a 23-fold increase risk of developing pulmonary hypertension, possibly years later.
Diuretics or âwater pillsâ in the treatment of pulmonary hypertension. Diuretics are commonly used to help treat heart failure. Because the right ventricle of pulmonary arterial hypertension patients is straining to pump against the increased pressures in the pulmonary arteries, they have the same volume management problem.