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Certain heart diseases. Heart diseases, including aortic valve disease, left heart failure, mitral valve disease, and congenital heart disease, can also cause pulmonary hypertension. Thromboembolic disease. A blood clot in a large pulmonary artery can result in the development of pulmonary hypertension.
1 One sysâ¦. 2  Coping With COPD: Reducing Pulmonary Hypertension Pulmonary hypertension from COPD (Chronic Obstructive Pulmonary Disease) is caused by a sharp increase in blood pressure in the pulmonary arteries. 3  This condition puts signifâ¦. 4  The Five Major Parts of the Brain At its most basic, the brain controls the body.