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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
In general, a low platelet count occurs because: 1  The body's bone marrow doesn't make enough platelets. 2  The bone marrow makes enough platelets, but the body destroys them or uses them up. 3  The spleen holds on to too many platelets.