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Irritating Skin Rashes: 13 Possible Causes. Not typically serious, but always irritating and embarrassing, skin rashes can be caused by a number of factorsâsuch as environment, infection, stress, heat, allergens, immune system disorders, and medication.
General causes of rash that can affect any part of the body, including the breast, include: 1  Atopic dermatitis (eczema) 2  Candidiasis (especially under the breasts) 3  Cellulitis (a skin infection)  Dermatitis.