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Although it is no bigger than a pea, the pituitary gland, located at the base of the brain just beneath the hypothalamus, is considered the most important part of the endocrine system. It's often called the master gland because it makes hormones that control several other endocrine glands.
1 Rate of production: Synthesis and secretion of hormones are the most highly regulated aspect of endocrine control. 2  Such control is mediated by positive and negative feedback circuits, as described below in more detail.