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The following are some known causes of pulmonary hypertension: 1  The diet drug fen-phen.. Although the appetite suppressant fen-phen (dexfenfluramine and phentermine) has been taken off the market, former fen-phen users have a 23-fold increase risk of developing pulmonary hypertension, possibly years later.
Pulmonary hypertension is a hemodynamic state defined by a resting mean pulmonary artery pressure at or above 25 mm Hg. Because this definition is based on hemodynamic criteria, pulmonary hypertension can be the result of a variety of diseases of different causes. Pulmonary arterial hypertension (PAH), however, should be distinctly differentiated from pulmonary venous hypertension resulting from left heart disease. PAH is characterized by elevations in the pulmonary arterial pressure and pulmonary vascular resistance (PVR) leading to right ventricular failure and premature death.