1 The first bomb dropped on Hiroshima was made from uranium. 2  The bomb dropped on Nagasaki was made from plutonium, which was even more powerful than uranium. 3  It is thought that at least 135,000 people died from the Hiroshima explosion and another 70,000 in Nagasaki.
Pharmacokinetic parameters of paclitaxel following 3- and 24-hour infusions of TAXOL at dose levels of 135 and 175 mg/m2 were determined in a Phase 3 randomized study in ovarian cancer patients and are summarized in the following table.
Unlike other medications where excessive dilution can potentially decrease effectiveness, exparel is a special liposomal release bupivicaine (translation: the active numbing medicine is in a special release construct that very slowly releases over time (up to 72 hours or more of effects). Proper Dilution of Exparel does NOT decrease its effectiveness.