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Although it is no bigger than a pea, the pituitary gland, located at the base of the brain just beneath the hypothalamus, is considered the most important part of the endocrine system. It's often called the master gland because it makes hormones that control several other endocrine glands.
Confidence votes 67. Simply put, the hypothalamus is connected directly to the pituitary gland. The pituitary gland is a major part of the endocrine system as it is the connection between the endocrine system and the brain.ecause many of these hormones regulate the activity of the pituitary gland, which is often called the master regulator of the endocrine system, the hypothalamus is often considered the ultimate regulator of the endocrine system. 9 people found this useful.