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The following are some known causes of pulmonary hypertension: 1  The diet drug fen-phen.. Although the appetite suppressant fen-phen (dexfenfluramine and phentermine) has been taken off the market, former fen-phen users have a 23-fold increase risk of developing pulmonary hypertension, possibly years later.
Pulmonary hypertension is a lung condition in which there is increased pressure in the pulmonary arteries that travel from the heart to the lungs. The most common symptoms are shortness of breath and fatigue. Other more severe symptoms are chest pain, palpitations, and dizziness. There is no cure for the disease, but it can be managed with medication.