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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
Best Answer: Occasional large platelets are a common finding on normal peripheral blood smears. They represent younger platelets, and in the clinical situation of increased WBC counts with an infection, indicate an active bone marrow. Do not be concerned. had routine bloodwork done and I had high WBC and large platelets. my mother had APL (type of leukemia) thoughts???? I currently have an infection so maybe that's why the white blood cells are high, but what exactly do large platelets mean? I've googled but most answers talk about platelet COUNT and not SIZE.