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The following are some known causes of pulmonary hypertension: 1  The diet drug fen-phen.. Although the appetite suppressant fen-phen (dexfenfluramine and phentermine) has been taken off the market, former fen-phen users have a 23-fold increase risk of developing pulmonary hypertension, possibly years later.
Most patients with pulmonary hypertension can manage the condition at home with regular follow-up visits with their doctor. In cases of mild pulmonary hypertension with minimal or no symptoms, no special treatment other than those required for the underlying cause may be required.