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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
Platelets are constantly being produced in the bone marrow. A low or high platelet count is not often a problem by itself, but can frequently be a sign of another medical condition. For this reason, high or low platelet counts require additional medical attention.8 Followers. A. Platelets are the tiny blood cells that help stop bleeding by binding together to form a clump or plug at sites of injury inside blood vessels. A normal platelet count is between 150,000 and 450,000 platelets per microliter (one-millionth of a liter, abbreviated mcL).