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In addition, the neurotransmitter can bind to any one of the nearby smooth muscle cells, a flexibility not found in the NMJ. The chemicals that influence smooth muscle cells: As you'll recall, there is only one neurotransmitter released at the neuromuscular junction-acetylcholine.
The released neurotransmitter may then move across the synapse to be detected by and bind with receptors in the postsynaptic neuron. Binding of neurotransmitters may influence the postsynaptic neuron in either an inhibitory or excitatory way. Enzyme degradation â special chemicals called enzymes break it down. 2  Reuptake â re-absorption of a neurotransmitter into the neuron. 3  Transporters, or membrane transport proteins, pump neurotransmitters from the synaptic cleft back into axon terminals (the presynaptic neuron) where they are stored.