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Certain heart diseases. Heart diseases, including aortic valve disease, left heart failure, mitral valve disease, and congenital heart disease, can also cause pulmonary hypertension. Thromboembolic disease. A blood clot in a large pulmonary artery can result in the development of pulmonary hypertension.
Many people with pulmonary hypertension may have no symptoms at all, especially if the disease is mild or in the early stages. Pulmonary hypertension symptoms may include: Shortness of breath that worsens with activity; Other common complaints are cough, fatigue, dizziness, and lethargy.