On average, the life expectancy of peritoneal mesothelioma patients is 12 months. However, multiple studies have shown that patients who have cytoreduction with HIPEC experience significantly longer survival times. Many patients now survive up to 5 years and some even live beyond 7 years.
It was written by co-creator Mark Gatiss, who also portrays Mycroft Holmes, Sherlock's brother in the series, and was directed by Paul McGuigan. The episode is a contemporary adaptation of The Hound of the Baskervilles, one of Sir Arthur Conan Doyle 's most famous works.
Watson appears on the 2010 direct-to-DVD Asylum film Sir Arthur Conan Doyle's Sherlock Holmes, a science fiction reinvention in which he is portrayed by actor Gareth David-Lloyd. At the beginning of the film, Watson is an elderly man portrayed by David Shackleton during the Blitz in 1940.