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1. In some cases, the cofactor completes the active site of the enzyme or modifies it in such a manner that substrate binding can ensue. 2. The cofactor acts as a donor of electrons or atoms to the substrate and following the reaction is returned to its former state.
1 This binding to an allosteric site changes the conformation of the enzyme so that the affinity of the substrate for the active site is reduced. 2  These inhibitors lower the K m and V m. 3  File:Uncompetitive inhibition.docx. 4  mixed inhibition the inhibitors can bind to the enzyme at the same time as the enzyme substrate.