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Total iron binding capacity (TIBC) is a blood test to see if you have too much or too little iron in the blood. Iron moves through the blood attached to a protein called transferrin. This test helps your doctor know how well that protein can carry iron in the blood.
1 Serum iron measures the level of iron in the liquid portion of the blood. 2  TIBC (total iron-binding capacity) measures all of the proteins in the blood that are available to bind with iron, including transferrin. 3  UIBC (unsaturated iron-binding capacity) measures the portion of transferrin that has not yet been saturated.