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A high number of large platelets (high MPV) in a person with a low platelet count suggests the bone marrow is producing platelets and releasing them into circulation rapidly. Conversely, the MPV may be low in people with low platelet counts due to a disorder affecting production by the bone marrow.
Platelet count is the number of platelets in the blood. A normal platelet count ranges from 150,000 to 350,000. If the number of platelets is too low, excessive bleeding can occur. The medical name for a low platelet count is thrombocytopenia (throm-bo-sigh-toe-PEE-nee-uh). Some things can affect how well the bone marrow can produce platelets. When not enough platelets are made, the platelet count in your blood is too low. Chemotherapy and some radiation therapy can cause this temporarily. These cancer treatments can slow the production of platelets in the bone marrow.