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How alcohol and ecstasy affect ADH. Alcohol suppresses ADH production. This causes the kidneys to produce more dilute urine. It can lead to dehydration. Ecstasy increases ADH production. This causes the kidneys to reabsorb water. It can result in the body having too much water.
The system exerts its influence via release or inhibition of vasopressin (antidiuretic hormone, ADH) which acts on the kidney to decrease water excretion. Deficiency of ADH is usually due to hypothalamic-neurohypophyseal lesions (central diabetes insipidus) or insensitivity of the kidney to ADH (nephrogenic diabetes insipidus). These patients, if untreated, have the predictable result of dehydration, hyperosmolality, hypovolemia, and eventual death in severe cases.