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Irritating Skin Rashes: 13 Possible Causes. Not typically serious, but always irritating and embarrassing, skin rashes can be caused by a number of factorsâsuch as environment, infection, stress, heat, allergens, immune system disorders, and medication.
2. 10% of hives and rashes on face are caused by medications and drugs. The following medications can cause skin rashes and hives: â Antibiotics like penicillins, sulfas, cephalosporins, tetracyclines, and polymyxin. â Heart medications like beta blockers, ACE inhibitors, and diuretics.