Under dehydrated conditions, the cells may lose up to 28% or more of their water volume. This certainly undermines all cellular activities, whether they occur in skin cells, stomach cells, liver cells, kidney cells or heart cells.
In Addison's disease, the adrenal glands don't make enough of a hormone called cortisol, or less often, a related hormone called aldosterone. That's why doctors sometimes call the illness ''chronic adrenal insufficiency,'' or hypocortisolism.
Addison's Disease. Addisons disease is a disorder that occurs when your body fails to produce enough hormones (cortisol and aldosterone) in your adrenal gland. These hormones helps the body respond to stress and helps maintain blood pressure as well as water and salt balance in your body.