Osteoarthritis is a disease of the joints. Unlike many other forms of arthritis, such as rheumatoid arthritis and systemic lupus, osteoarthritis does not affect other organs of the body.The most common symptom of osteoarthritis is pain in the affected joints after repetitive use.Joint pain is usually worse later in the day.steoarthritis Overview. Osteoarthritis (OA) is caused by aging joints, injury, and obesity. OA symptoms include joint pain and stiffness. Treatment depends on the affected joint, including the hand, wrist, neck, back, knee, and hip, and involves medication and exercise.
Sleep deprivation (DEP-rih-VA-shun) is a condition that occurs if you don't get enough sleep. Sleep deficiency is a broader concept. It occurs if you have one or more of the following: 1  You don't get enough sleep (sleep deprivation). 2  You sleep at the wrong time of day (that is, you're out of sync with your body's natural clock). 3  You don't sleep well or get all of the different types of sleep that your body needs.
Twenty-four hours of sleep deprivation has been found to affect the functional connectivity between the inferior frontal parietal region (IPS) and the parahippocampal place area (PPA). However, sleep deprivation does not affect the attention modulation index of the PPA.erotonin levels (in the form of 5-HT) have been shown to decrease during REM and NREM sleep, leading some researchers to believe that it is also involved in memory consolidation during sleep. Mice lacking the receptor gene for 5-HT engage in more REM sleep and perform better on spatial memory tasks.