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Prophylaxis of gout flares: If the original colchicine dose was 0.6 mg twice daily, 0.6 mg daily or 0.3 mg twice daily should be given. For an original dose of 0.6 mg daily, the adjusted dose is 0.3 mg daily.Treatment of gout flares: Take 1.2 mg Ã 1 dose of colchicine; at least 3 days should elapse before repeating.rophylaxis of gout flares: If the original colchicine dose were 0.6 mg twice daily, 0.3 mg should be given once daily. For an original dose of 0.6 mg daily, the adjusted dose is 0.3 mg every other day.
In order to avoid side effects from colchicine the dose of colchicine should be reduced when it is combined with or used within 14 days of drugs that reduce its elimination. Examples of drugs that reduce the elimination of colchicine include: 1  atazanavir (Reyataz),  clarithromycin (Biaxin),