Meticulously directed by Mendes and brilliantly photographed by Conrad Hall, each scene of ROAD TO PERDITION has the composition of an expertly rendered painting. Making effective use of rain, snow, and shadows, the filmmakers create a cinematic world that's as dark, cold, and unforgiving as many of its inhabitants.
People who have severe hemophilia have spontaneous bleeding into the joints and muscles. Hemophilia occurs more commonly in males than in females. The two most common types of hemophilia are hemophilia A (also known as classic hemophilia) and hemophilia B (also known as Christmas disease). People who have hemophilia A have low levels of a blood clotting factor called factor eight (FVIII).
Hemophilia is an X linked or sex linked inherited disorder which means that the defect is carried on the X chromosome. Females have two X chromosomes and males have one X chromosome and one Y chromosome. The X chromosome, which carries the hemophilia gene in males, causes Factor VIII or Factor IX to be missing or deficient (low level). Each child of a hemophilia carrier has a 50% chance of being affected by hemophilia; either having hemophilia for a male or being a carrier for a female.