Under dehydrated conditions, the cells may lose up to 28% or more of their water volume. This certainly undermines all cellular activities, whether they occur in skin cells, stomach cells, liver cells, kidney cells or heart cells.
In Addison's disease, the adrenal glands don't make enough of a hormone called cortisol, or less often, a related hormone called aldosterone. That's why doctors sometimes call the illness ''chronic adrenal insufficiency,'' or hypocortisolism.
Addisonâs disease is an extremely rare disorder, affecting only 4-11 out of every 100,000 individuals around the world at any given time. Addisonâs disease does not have any age or gender bias and can affect both males and females of an age with equal probability. Causes of Addisonâs Disease: Addisonâs disease is developed as a disorder of the adrenal glands.