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The Red Cross is also a leader in research and testing to protect the safety of the blood supply. We were among the first to develop and implement testing for many infectious diseases including, HIV, hepatitis B and C viruses, West Nile virus, and more recently the agent of Chagas disease.
Direct Coombs Testing. A Coombs test is performed to detect the presence of antibody against red blood cells. The test is used to support the diagnosis of immune-mediated hemolytic anemia (IHA). Up to 66-75% of dogs with IHA will have a positive Coombs test.he direct Coombs test is more sensitive than the indirect Coombs test, which assesses for antibody in the patient's serum to red cells. In some patients with IHA, all of their antibody may be attached to their red cells, therefore they may have a negative indirect Coombs test, but a positive direct Coombs test.