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Not surprisingly, mental illness often prolongs homelessness. Approximately 26 percent of homeless adults staying in shelters live with serious mental illness and an estimated 66 percent live with severe mental illness and/or substance use disorders.
Mental illnesses can increase the risk for alcoholism or drug abuse, sometimes because of self-medicating. On the other hand, alcoholism can lead to significant anxiety and depression that may appear indistinguishable from a mental illness. There is also evidence that addiction and mental disorders are associated with the dysfunction of a group of brain chemicals called monoamine oxidases. 2  Shared environment. 3  Studies surrounding twins also showed that environment plays a major role in having both a substance abuse problem and another mental disorder.