Under dehydrated conditions, the cells may lose up to 28% or more of their water volume. This certainly undermines all cellular activities, whether they occur in skin cells, stomach cells, liver cells, kidney cells or heart cells.
In Addison's disease, the adrenal glands don't make enough of a hormone called cortisol, or less often, a related hormone called aldosterone. That's why doctors sometimes call the illness ''chronic adrenal insufficiency,'' or hypocortisolism.
Addisonâs Disease. Addisonâs disease is a disease of the Adrenal Cortex caused by autoimmune destruction of the Adrenal gland with fibrosis and mononuclear cell infiltration. Symptoms become evident when more than 90% of the Adrenal gland is destroyed.