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For a 3- to 4-pound corned beef brisket, plan to cook it in a slow cooker for 10 to 12 hours on the low heat setting or 5 to 6 hours on the high heat setting. Get instructions on how to cook corned beef. Find the Perfect Slow Cooker Recipe!
Assuming a 10-12 pound whole brisket and 1-1/2 hours of cooking time per pound as a guideline, calculate how long it will take to cook the brisket. For example, a 12 pound brisket will take approximately 18 hours to cook. Divide this time in half. The first time to turn the brisket is after 9 hours of cooking.