Meticulously directed by Mendes and brilliantly photographed by Conrad Hall, each scene of ROAD TO PERDITION has the composition of an expertly rendered painting. Making effective use of rain, snow, and shadows, the filmmakers create a cinematic world that's as dark, cold, and unforgiving as many of its inhabitants.
People who have severe hemophilia have spontaneous bleeding into the joints and muscles. Hemophilia occurs more commonly in males than in females. The two most common types of hemophilia are hemophilia A (also known as classic hemophilia) and hemophilia B (also known as Christmas disease). People who have hemophilia A have low levels of a blood clotting factor called factor eight (FVIII).
Inherited hemophilia. In 70% of cases of hemophilia, there is a known family history. The gene that causes hemophilia is passed from mother to child. A mother that carries the gene is called a carrier. A carrier has a 50% chance of having a son with hemophilia and a 50% chance of having a daughter who is also a carrier.In other words, a female carrier has a 25% chance of having a child with hemophilia. female can have Hemophilia because of X-inactivation or Lyonization. It is possible for one X to âshut-downâ or not to express itself. If the X chromosome with the Hemophilia gene is the active chromosome than she will have lower levels. 50% of carriers have low factor levels.