The mean time to onset of a 12% increase in FEV1 for PROVENTIL HFA Inhalation Aerosol was 7 minutes and the mean time to peak effect was approximately 50 minutes. The mean duration of effect as measured by a 12% increase in FEV1 was 2.3 hours. In some pediatric patients, duration of effect was as long as 6 hours.
The Aztecs, who probably originated as a nomadic tribe in northern Mexico, arrived in Mesoamerica around the beginning of the 13th century.
From there, the Mexica settled Tenochtitlan, which is modern-day Mexico City. The Aztecs expanded quickly during the 14th and 5th centuries, building canals and settling much of modern-day Mexico. Cortez arrived on the Yucatan peninsula on 1519, and this was the beginning of the end for the Aztec Empire.