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Tests and diagnosis. Shingles is usually diagnosed based on the history of pain on one side of your body, along with the telltale rash and blisters. Your doctor may also take a tissue scraping or culture of the blisters for examination in the laboratory. 1  Preparing for your appointment.2  Treatments and drugs.hingles is usually diagnosed based on the history of pain on one side of your body, along with the telltale rash and blisters. Your doctor may also take a tissue scraping or culture of the blisters for examination in the laboratory. 1  Preparing for your appointment. 2  Treatments and drugs.
Shingles Diagnosis Without a Rash. Some people have burning, painful, itchy sensations on one area of skin, but they don't get a rash (or the shingles rash has yet to appear). If there is no rash, the symptoms can be difficult to diagnose because they can be mistaken for several other diseases.In cases where there is no rash, or the diagnosis is questionable, doctors can do a blood test.If there is a rash, but it does not resemble a typical shingles outbreak, skin scrapings from the sores can also be used.f there is no rash, the symptoms can be difficult to diagnose because they can be mistaken for several other diseases. In cases where there is no rash, or the diagnosis is questionable, doctors can do a blood test.