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Pernicious anemia is a rare blood disorder characterized by the inability of the body to properly utilize vitamin B12, which is essential for the development of red blood cells. Most cases result from the lack of the gastric protein known as intrinsic factor, without which vitamin B12 cannot be absorbed.
The symptoms of pernicious anemia can vary amongst individuals, depending on the cause, the severity of anemia, and other factors. Direct symptoms of pernicious anemia are due to a lack of red blood cells, which are vital to carrying oxygen to the cells of the body.Symptoms can include pale skin, shortness of breath, fatigue, dizziness, headache, cold hands and feet, heart palpitations, and chest pain.ore information about symptoms of Pernicious anemia and related conditions: 1  Other diseases with similar symptoms and common misdiagnoses. 2  Tests to determine if these are the symptoms of Pernicious anemia. 3  Symptoms that may be caused by complications of Pernicious anemia. 4  Underlying causes of Pernicious anemia.