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Cellular respiration is a set of metabolic reactions and processes that take place in the cells of organisms to convert biochemical energy from nutrients into adenosine triphosphate (ATP), and then release waste products.
Anaerobic respiration occurs in the cytoplasm in the absence of oxygen. Aerobic respiration uses NADH to produce large amounts of ATP in the presence of oxygen (releasing NAD+) In the absence of oxygen, the NADH remains idle and cannot be used to release NAD+. This means glycolysis cannot occur (no spare NAD+) and no ATP can be produced.