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Prophylaxis of gout flares: If the original colchicine dose was 0.6 mg twice daily, 0.6 mg daily or 0.3 mg twice daily should be given. For an original dose of 0.6 mg daily, the adjusted dose is 0.3 mg daily.Treatment of gout flares: Take 1.2 mg Ã 1 dose of colchicine; at least 3 days should elapse before repeating.rophylaxis of gout flares: If the original colchicine dose were 0.6 mg twice daily, 0.3 mg should be given once daily. For an original dose of 0.6 mg daily, the adjusted dose is 0.3 mg every other day.
Initially 20mg once daily; after â¥1 week may increase to 40mg once daily. Doses >40mg/day: not recommended. Elderly (>60yrs), hepatic impairment, CYP2C19 poor metabolizers, concomitant cimetidine or other CYP2C19 inhibitors: max 20mg/day. 3rd trimester pregnant women: consider tapering dose.