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Intrinsic muscles. Definition. noun. A group of muscles located within or situated deeper in a structure, in contrast to extrinsic muscles located rather superficially. Supplement. Based on the above definition, the intrinsic muscles refer to the muscles closest to the axial and appendicular skeleton.For example, the intrinsic muscles of the hand are those lying deeper in the hand, such as the interossei and lumbrical muscles.ased on the above definition, the intrinsic muscles refer to the muscles closest to the axial and appendicular skeleton. For example, the intrinsic muscles of the hand are those lying deeper in the hand, such as the interossei and lumbrical muscles.
Muscles acting on the hand can be divided into two groups; extrinsic and intrinsic muscles. 1  The extrinsic muscles are located in the anterior and posterior compartments of the forearm.2  They control crude movements, and produce a forceful grip.3  The intrinsic muscles of the hand are located within the hand itself.uscles acting on the hand can be divided into two groups; extrinsic and intrinsic muscles. 1  The extrinsic muscles are located in the anterior and posterior compartments of the forearm. 2  The intrinsic muscles of the hand are located within the hand itself.