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Tests and diagnosis. Shingles is usually diagnosed based on the history of pain on one side of your body, along with the telltale rash and blisters. Your doctor may also take a tissue scraping or culture of the blisters for examination in the laboratory. 1  Preparing for your appointment.2  Treatments and drugs.hingles is usually diagnosed based on the history of pain on one side of your body, along with the telltale rash and blisters. Your doctor may also take a tissue scraping or culture of the blisters for examination in the laboratory. 1  Preparing for your appointment. 2  Treatments and drugs.
Some doctors only treat symptoms of shingles, such as pain, when the disease is diagnosed later than 72 hours after the rash develops. Pain relievers, such as acetaminophen (Tylenol, for example), ibuprofen (Advil, for example), naproxen (Aleve), or tricyclic antidepressants are examples of some pain medications that may be used.