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Cellular respiration is a set of metabolic reactions and processes that take place in the cells of organisms to convert biochemical energy from nutrients into adenosine triphosphate (ATP), and then release waste products.
With decreased oxygen (hypoxia), the kidney cells are unable to produce sufficient ATP from cellular respiration. Once a cell lacks ATP, it lacks energy to carry out its functions. Therefore, the kidneys would not be sufficiently able to produce EPO and filter blood plasma.