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Tests and diagnosis. Shingles is usually diagnosed based on the history of pain on one side of your body, along with the telltale rash and blisters. Your doctor may also take a tissue scraping or culture of the blisters for examination in the laboratory. 1  Preparing for your appointment.2  Treatments and drugs.hingles is usually diagnosed based on the history of pain on one side of your body, along with the telltale rash and blisters. Your doctor may also take a tissue scraping or culture of the blisters for examination in the laboratory. 1  Preparing for your appointment. 2  Treatments and drugs.
Although the earliest appearance of shingles symptoms is sometimes confused with hives (raised areas of itchy skin), bedbug bites, or scabies (skin infection by scabies mite), the classic pain, and blistering in a band on one side of the body may be all that is necessary for a doctor to clinically diagnose herpes zoster infection (shingles).