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Florence is located on the Oregon Coast at the mouth of the Siuslaw River immediately north of Oregon Dunes National Recreation Area, at about the same latitude as Eugene, Oregon. It is approximately midway between the other major central Oregon coastal cities of Newport and Coos Bay.
Florence, South Carolina. South Carolina Florence County Florence The City of Florence is the seat of Florence County. It is located in eastern South Carolina where I-95 and I-20 intersect. Florence is a common stop for travelers headed to Myrtle Beach. Here is a map of the Florence area.