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Florence is located on the Oregon Coast at the mouth of the Siuslaw River immediately north of Oregon Dunes National Recreation Area, at about the same latitude as Eugene, Oregon. It is approximately midway between the other major central Oregon coastal cities of Newport and Coos Bay.
There are several parks and other sites managed by the Oregon Parks and Recreation Department near Florence, including Darlingtonia State Natural Site and Heceta Head Lighthouse at Devil's Elbow to the north, and Jessie M. Honeyman Memorial State Park to the south.