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For a 3- to 4-pound corned beef brisket, plan to cook it in a slow cooker for 10 to 12 hours on the low heat setting or 5 to 6 hours on the high heat setting. Get instructions on how to cook corned beef. Find the Perfect Slow Cooker Recipe!
Slow cookers are a great way to prepare brisket. However, how long you cook it depends on the brisket size. Cooking on the low setting, a brisket under 3 pounds will cook within 6-8 hours and larger briskets (above 4 pounds) will take 8-11 hours to cook.add a comment.owever, how long you cook it depends on the brisket size. Cooking on the low setting, a brisket under 3 pounds will cook within 6-8 hours and larger briskets (above 4 pounds) will take 8-11 hours to cook. add a comment.