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1 Since liver disease (including liver failure and cirrhosis) can increase your risk of lactic acidosis, you should not take glyburide and metformin if your liver is not functioning normally. 2  Also, your kidney function needs to be monitored while you are taking glyburide and metformin. If you are allergic to sulfonamides (sulfa medications), you may also be allergic to glyburide and metformin -- though most people with sulfa allergies can take glyburide and metformin without problems. 2  Let your healthcare provider know if you have a sulfa allergy.
I also have cirrhosis from Hepatitis C. A: Glyburide (Diabeta) is a sulfonylurea used in the treatment of type 2 diabetes. All sulfonylurea drugs are capable of producing severe hypoglycemia (low blood sugar levels). Proper patient selection, dosage, and instructions are important to avoid hypoglycemic episodes.: Glyburide is a medication used in the treatment of type 2 diabetes. Type 2 diabetes is a condition when the body is not able to process the sugar in the blood, leading to high levels of glucose in the blood.