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Florence is located on the Oregon Coast at the mouth of the Siuslaw River immediately north of Oregon Dunes National Recreation Area, at about the same latitude as Eugene, Oregon. It is approximately midway between the other major central Oregon coastal cities of Newport and Coos Bay.
Cave Junction is located on U.S. Route 199 at its junction with Oregon Route 46. It is about 48 kilometres (30 mi) southwest of Grants Pass, Oregon and 85 kilometres (53 mi) northeast of Crescent City, California.