The action of nicotine in the body is very complicated. It is a mild stimulant which has an effect upon the heart and brain. It stimulates the central nervous system causing irregular heartbeat and blood pressure, induces vomiting and diarrhea, and first stimulates, then inhibits glandular secretions.
The control number for this collection is 1651-0121. The estimated average time to complete this application is 40 minutes for SENTRI, FAST and Global Entry, and 10 minutes for U.S. APEC Business Traveler Card (ABTC).
After the interview, if you are approved, you will be able to use the program immediately. The Global Entry card, which can be used only for land entries to the US, arrived in the mail 7-10 days later. So the longest potential timelag is between approval and interview.