Under dehydrated conditions, the cells may lose up to 28% or more of their water volume. This certainly undermines all cellular activities, whether they occur in skin cells, stomach cells, liver cells, kidney cells or heart cells.
In Addison's disease, the adrenal glands don't make enough of a hormone called cortisol, or less often, a related hormone called aldosterone. That's why doctors sometimes call the illness ''chronic adrenal insufficiency,'' or hypocortisolism.
(Also Called 'Chronic Adrenal Insufficiency'). Addisonâs disease is a disorder in which the adrenal glands--which sit on top of the kidneys--do not produce enough of the hormones cortisol and aldosterone. (Hormones are chemicals that control the function of tissues or organs.).ther causes of Addisonâs disease include: 1  injury to the adrenal glands. 2  infection, including tuberculosis, HIV/AIDS-related infections, and fungal infections. 3  cancer cells from another part of the body that have invaded the adrenal glands. 4  bleeding into the adrenal glands. 5  surgical removal of the adrenal glands.