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Intrinsic muscles. Definition. noun. A group of muscles located within or situated deeper in a structure, in contrast to extrinsic muscles located rather superficially. Supplement. Based on the above definition, the intrinsic muscles refer to the muscles closest to the axial and appendicular skeleton.For example, the intrinsic muscles of the hand are those lying deeper in the hand, such as the interossei and lumbrical muscles.ased on the above definition, the intrinsic muscles refer to the muscles closest to the axial and appendicular skeleton. For example, the intrinsic muscles of the hand are those lying deeper in the hand, such as the interossei and lumbrical muscles.
By Ground Up Strength. The muscles that move the hand are divided into two groups, the extrinsic and intrinsic muscles. The extrinsic muscles of the hand are the powerful flexor and extensor muscles of the forearm. These muscles originate outside the hand and insert within the hand. Since they are located and originate on the forearm outside the hand itself, they are called extrinsic which comes from the Latin word extrinsecus meaning on the outside.