Parental therapy: Sub-Q preferred because of hypersensitivity risk with IV or IM administration.a (See Boxed Warning.) Route of administration depends on the severity of the prothrombin deficiency and the risks associated with administration by each route.c.
Brand name medicines appear in green; generic medicines appear in red. Donât confuse Depakote with Depakote ER. Depakote (divalproex sodium) ER is a medicine used to treat seizure disorders, migraine headaches, and certain mental illnesses such as bipolar disorder. The âERâ part of the name stands for âextended release,â meaning the contents of the medicine are released slowly, not all at once, after you take the medicine.
â¢ Most clinicians dose Depakote at bedtime in order to increase compliance and minimize side effects, regardless of the formulation used. â¢ Start at 250-500 mg QHS, gradually increasing to achieve a blood Depakote level of 70-80 mcg/mL, which will often be in the 1000-1250 mg QHS range. â¢ When converting from regular Depakote to Depakote ER, be aware that patients will see about 20% less. valproic acid with the ER formulation, making converting somewhat tricky, given that Depakote ER only. comes in the 500 mg option.