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Tests and diagnosis. Shingles is usually diagnosed based on the history of pain on one side of your body, along with the telltale rash and blisters. Your doctor may also take a tissue scraping or culture of the blisters for examination in the laboratory. 1  Preparing for your appointment.2  Treatments and drugs.hingles is usually diagnosed based on the history of pain on one side of your body, along with the telltale rash and blisters. Your doctor may also take a tissue scraping or culture of the blisters for examination in the laboratory. 1  Preparing for your appointment. 2  Treatments and drugs.
If elevated white blood cells are observed, your doctor may test your blood for antibodies to the herpes zoster virus. Antibodies are proteins that your body makes due to infections and can be detected by laboratory tests.f there is any uncertainty as to whether the patient's symptoms are caused by shingles and the blood tests indicate that shingles might be present, doctors may take a sample of the tissue from the blisters or ulcers.