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Pernicious anemia is a rare blood disorder characterized by the inability of the body to properly utilize vitamin B12, which is essential for the development of red blood cells. Most cases result from the lack of the gastric protein known as intrinsic factor, without which vitamin B12 cannot be absorbed.
Pernicious anemia: Low red blood cell count caused by inadequate vitamin B12. Abbreviated PA. Patients with PA do not produce intrinsic factor (IF), a substance that allows the body to absorb vitamin B12 from foods. The resulting inadequacy of vitamin B12 hampers the production of red blood cells.ernicious anemia: Low red blood cell count caused by inadequate vitamin B12. Abbreviated PA. Patients with PA do not produce intrinsic factor (IF), a substance that allows the body to absorb vitamin B12 from foods. The resulting inadequacy of vitamin B12 hampers the production of red blood cells.