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Tests and diagnosis. Shingles is usually diagnosed based on the history of pain on one side of your body, along with the telltale rash and blisters. Your doctor may also take a tissue scraping or culture of the blisters for examination in the laboratory. 1  Preparing for your appointment.2  Treatments and drugs.hingles is usually diagnosed based on the history of pain on one side of your body, along with the telltale rash and blisters. Your doctor may also take a tissue scraping or culture of the blisters for examination in the laboratory. 1  Preparing for your appointment. 2  Treatments and drugs.
Your doctor will ask about your pain history and perform a physical exam. For most people with shingles, a rash and blisters will form along the chest or back. This rash is often accompanied by pain. Your doctor may take a scraping or culture of these blisters for lab tests.our doctor will ask about your pain history and perform a physical exam. For most people with shingles, a rash and blisters will form along the chest or back. This rash is often accompanied by pain. Your doctor may take a scraping or culture of these blisters for lab tests.