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Florence is located on the Oregon Coast at the mouth of the Siuslaw River immediately north of Oregon Dunes National Recreation Area, at about the same latitude as Eugene, Oregon. It is approximately midway between the other major central Oregon coastal cities of Newport and Coos Bay.
Portland is located 60 miles east of the Pacific Ocean at the northern end of Oregon's most populated region, the Willamette Valley. Downtown Portland straddles the banks of the Willamette River, which flows north through the city center and consequently separates the east and west neighborhoods of the city.