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CONN'S DISEASE. A condition characterized by excretion of excessive amounts of aldosterone, the most influential of the mineralocorticoids, which causes the body to retain extra sodium and excrete extra potassium, leading to an increased volume of blood (hypervolemia) and hypertension.
Hyperglycemia, osmotic diuresis, serum hyperosmolarity, and metabolic acidosis result in severe electrolyte disturbances. The most characteristic disturbance is total body potassium loss. Total body potassium loss is usually present despite normal or high serum potassium levels. Potassium levels may appear to be high due to the transcellular shift of potassium out of cells. This is not due to ketoacidosis directly but rather is due to insulin deficiency and hyperosmolality.