Under dehydrated conditions, the cells may lose up to 28% or more of their water volume. This certainly undermines all cellular activities, whether they occur in skin cells, stomach cells, liver cells, kidney cells or heart cells.
In Addison's disease, the adrenal glands don't make enough of a hormone called cortisol, or less often, a related hormone called aldosterone. That's why doctors sometimes call the illness ''chronic adrenal insufficiency,'' or hypocortisolism.
Addison's disease is a medical condition in which the adrenal glands stop making hormones important for certain bodily functions. Addison's disease is characterized by weight loss, muscle weakness, fatigue, low blood pressure, and sometimes darkening of the skin in both exposed and non-exposed parts of the body.Other names for Addison's disease include primary adrenal insufficiency and hypocortisolism.ortisol. Cortisol belongs to a class of hormones called glucocorticoids, which affect almost every organ and tissue in the body. Scientists think that cortisol has possibly hundreds of effects in the body. Cortisol's most important job is to help the body respond to stress.