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Florence is located on the Oregon Coast at the mouth of the Siuslaw River immediately north of Oregon Dunes National Recreation Area, at about the same latitude as Eugene, Oregon. It is approximately midway between the other major central Oregon coastal cities of Newport and Coos Bay.
On average, there are 160 sunny days per year in Florence, Oregon. The July high is around 68 degrees. The January low is 40. Sperling's comfort index for Florence is a 76 out of 100, where a higher score indicates a more comfortable year-around climate. The US average for the comfort index is 54.