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The Red Cross is also a leader in research and testing to protect the safety of the blood supply. We were among the first to develop and implement testing for many infectious diseases including, HIV, hepatitis B and C viruses, West Nile virus, and more recently the agent of Chagas disease.
Two blood tests can check for antibodies that attack red blood cells: the direct Coombs test and the indirect Coombs test. The direct Coombs test is done on a sample of red blood cells from the body. It detects antibodies that are already attached to red blood cells. The indirect Coombs test is done on a sample of the liquid part of the blood (serum).