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Tests and diagnosis. Shingles is usually diagnosed based on the history of pain on one side of your body, along with the telltale rash and blisters. Your doctor may also take a tissue scraping or culture of the blisters for examination in the laboratory. 1  Preparing for your appointment.2  Treatments and drugs.hingles is usually diagnosed based on the history of pain on one side of your body, along with the telltale rash and blisters. Your doctor may also take a tissue scraping or culture of the blisters for examination in the laboratory. 1  Preparing for your appointment. 2  Treatments and drugs.
The test is usually used to confirm a diagnosis of chicken pox or shingles when the patient has atypical symptoms; in most cases, doctors can diagnose the conditions based on a physical examination because they produce distinctive skin rashes; however, this is not always the case and a blood test may be required.f the test has been used to detect antibodies and both VZV IgG and IgM are detected, this usually indicates that the person has been exposed to the varicella zoster virus and has chicken pox; it may also mean that the infection has recurred and the patient has shingles.