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Florence is located on the Oregon Coast at the mouth of the Siuslaw River immediately north of Oregon Dunes National Recreation Area, at about the same latitude as Eugene, Oregon. It is approximately midway between the other major central Oregon coastal cities of Newport and Coos Bay.
Florence County, South Carolina. Florence County is a county located in the U.S. state of South Carolina. As of the 2010 census, its population was 136,885. Its county seat is Florence. Florence County is included in the Florence, SC Metropolitan Statistical Area. The county's population is about 60% urban.