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Queries run slower because of the joins. It is necessary to assign relationships to interact with different tables. Data will lose when dinormalising. Some disadvantages of normalization are that it creates an average, it is not precise, and takes away from the true results. This is helpful when determining overall results across many samples.
The reversal design can be extended indefinitely. A standard variation is the BAB design. The main disadvantage of the ABA design is its inability to be used with variables with irreversible effects or when it is undesirable to return to a baseline condition for practical or ethical reasons.