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Queries run slower because of the joins. It is necessary to assign relationships to interact with different tables. Data will lose when dinormalising. Some disadvantages of normalization are that it creates an average, it is not precise, and takes away from the true results. This is helpful when determining overall results across many samples.
Best Answer: The biggest disadvantage is that the mapping is carried out on a few individual's genome, and is not representative of all humans.It doesn't answer questions about where the coding of a gene starts and ends, nor does it answer questions about regulation of that gene.est Answer: The biggest disadvantage is that the mapping is carried out on a few individual's genome, and is not representative of all humans.